Manolis Pasparakis
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Biology
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(Suggest an Edit or Addition)Manolis Pasparakis's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
- Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. (1999) (1391)
- Necroptosis and its role in inflammation (2015) (1371)
- Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response (1996) (1234)
- Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury (2008) (1215)
- Epithelial NEMO links innate immunity to chronic intestinal inflammation (2007) (1051)
- Synchronized renal tubular cell death involves ferroptosis (2014) (687)
- SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis (2011) (676)
- Mechanisms regulating skin immunity and inflammation (2014) (648)
- Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis (1999) (550)
- FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation (2011) (538)
- Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer (2010) (524)
- Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma (2007) (517)
- Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases (2009) (516)
- TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2 (2002) (495)
- RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis (2014) (425)
- Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice (1997) (425)
- Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. (1999) (417)
- Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. (1995) (409)
- NF-κB in the regulation of epithelial homeostasis and inflammation (2011) (400)
- NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti (2000) (396)
- CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. (2012) (394)
- Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis (2019) (393)
- RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS (2016) (378)
- Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. (2008) (369)
- Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. (2007) (344)
- Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. (1998) (343)
- Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis (2016) (342)
- TRADD protein is an essential component of the RIG-like helicase antiviral pathway. (2008) (336)
- Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. (2003) (324)
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
- Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. (2006) (304)
- Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice (1997) (300)
- Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses (2008) (280)
- Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis (2010) (275)
- The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. (2011) (272)
- A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis (2011) (264)
- IKK mediates ischemia-induced neuronal death (2005) (262)
- Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. (2004) (254)
- Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. (2012) (254)
- Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo (2014) (250)
- RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation (2016) (239)
- Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor. (1997) (227)
- Mature T cells depend on signaling through the IKK complex. (2003) (222)
- MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death (2017) (214)
- Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. (2006) (214)
- K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. (2013) (214)
- IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells (2002) (204)
- Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice (2006) (203)
- Tumor Necrosis Factor (TNF) Receptor Shedding Controls Thresholds of Innate Immune Activation That Balance Opposing TNF Functions in Infectious and Inflammatory Diseases (2004) (201)
- In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis (1997) (200)
- p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation (2007) (198)
- RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4. (2016) (192)
- NEMO/IKK gamma-deficient mice model incontinentia pigmenti. (2000) (175)
- Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits (2014) (174)
- Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. (2005) (172)
- Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation (2020) (158)
- Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease (2019) (155)
- Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs. (2010) (154)
- TNF-α transgenic and knockout models of CNS inflammation and degeneration (1997) (151)
- A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling (1997) (150)
- Elevated serum levels of calcium‐binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis (2006) (147)
- Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis (2014) (147)
- Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte‐expressed protein (2004) (145)
- NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions (2016) (142)
- p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. (2007) (142)
- Dissection of the NF-κB signalling cascade in transgenic and knockout mice (2006) (141)
- The interplay of IKK, NF‐κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation (2017) (139)
- Tumor Necrosis Factor Alpha-Deficient, but Not Interleukin-6-Deficient, Mice Resist Peripheral Infection with Scrapie (2000) (138)
- Role of NF‐κB in epithelial biology (2012) (130)
- Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. (2013) (129)
- FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. (2006) (124)
- Sustained Oscillations of NF-κB Produce Distinct Genome Scanning and Gene Expression Profiles (2009) (117)
- Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells (2012) (115)
- Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. (2014) (111)
- Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. (1995) (109)
- Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. (2006) (109)
- Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis (2008) (109)
- A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases (2016) (108)
- FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. (2020) (106)
- Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. (2000) (104)
- Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. (2011) (101)
- ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING (2018) (100)
- TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein‐induced experimental autoimmune encephalomyelitis (1999) (97)
- Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation (2007) (97)
- p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin‐induced liver failure (2008) (97)
- BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells (2008) (96)
- Akt-dependent Activation of mTORC1 Complex Involves Phosphorylation of mTOR (Mammalian Target of Rapamycin) by IκB Kinase α (IKKα)* (2014) (95)
- IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system. (2011) (94)
- IKK/NF-κB signaling in intestinal epithelial cells controls immune homeostasis in the gut (2008) (93)
- IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages (2014) (93)
- Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance (2004) (92)
- A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain (2019) (92)
- NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis (2015) (91)
- IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver (2008) (91)
- Lipid signalling drives proteolytic rewiring of mitochondria by YME1L (2019) (90)
- B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice. (2016) (86)
- IKKβ/2 induces TWEAK and apoptosis in mammary epithelial cells (2006) (86)
- Listeria monocytogenes Infection in Macrophages Induces Vacuolar-Dependent Host miRNA Response (2011) (83)
- IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer (2015) (83)
- Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis (2011) (81)
- New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8. (2020) (81)
- The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells (2020) (79)
- Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice. (2006) (79)
- A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection (2012) (77)
- A novel liposomal Clodronate depletes tumor-associated macrophages in primary and metastatic melanoma: Anti-angiogenic and anti-tumor effects. (2016) (76)
- Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression (1999) (74)
- Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis (2014) (73)
- Inhibition of NF-κ B activation in macrophages increases atherosclerosis in LDL receptor – deficient mice (2003) (73)
- Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria. (2012) (70)
- Development of immunoglobulin λ-chain–positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals (2009) (70)
- TNF-alpha transgenic and knockout models of CNS inflammation and degeneration. (1997) (68)
- Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke (2020) (66)
- IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells. (2006) (63)
- TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice (2015) (63)
- Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment. (2019) (63)
- Brain endothelial TAK1 and NEMO safeguard the neurovascular unit (2015) (61)
- Complementation of Lymphotoxin α Knockout Mice with Tumor Necrosis Factor–expressing Transgenes Rectifies Defective Splenic Structure and Function (1998) (60)
- Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation (2020) (60)
- Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. (2004) (60)
- TNF-induced target cell killing by CTL activated through cross-presentation. (2012) (60)
- LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L (2018) (58)
- Oligodendrocyte-Specific FADD Deletion Protects Mice from Autoimmune-Mediated Demyelination (2010) (55)
- Dissection of the pathologies induced by transmembrane and wild‐type tumor necrosis factor in transgenic mice (1996) (51)
- Bacteria Regulate Intestinal Epithelial Cell Differentiation Factors Both In Vitro and In Vivo (2013) (50)
- RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome (2018) (50)
- Tumour necrosis factors in immune regulation: everything that's interesting is...new! (1996) (50)
- Conditional Targeting of Tumor Necrosis Factor Receptor–Associated Factor 6 Reveals Opposing Functions of Toll-Like Receptor Signaling in Endothelial and Myeloid Cells in a Mouse Model of Atherosclerosis (2012) (49)
- A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms (2019) (47)
- Epidermal p65/NF-κB signalling is essential for skin carcinogenesis (2014) (47)
- RIP Kinases in Liver Cell Death, Inflammation and Cancer. (2019) (47)
- Hematopoietic stem cell quiescence and function are controlled by the CYLD–TRAF2–p38MAPK pathway (2015) (45)
- The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils (2018) (44)
- GFP‐p65 knock‐in mice as a tool to study NF‐κB dynamics in vivo (2009) (42)
- CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice (2020) (41)
- Defective Osteoclastogenesis by IKKβ-null Precursors Is a Result of Receptor Activator of NF-κB Ligand (RANKL)-induced JNK-dependent Apoptosis and Impaired Differentiation* (2008) (40)
- IκB Kinase 2 Deficiency in T Cells Leads to Defects in Priming, B Cell Help, Germinal Center Reactions, and Homeostatic Expansion1 (2004) (40)
- Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide (2017) (39)
- RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation (2019) (38)
- Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling (2013) (37)
- CCR2+ monocytic myeloid‐derived suppressor cells (M‐MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor‐β1 (2017) (37)
- Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis. (2006) (36)
- Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout (2014) (35)
- IKKβ Deficiency in Myeloid Cells Ameliorates Alzheimer's Disease-Related Symptoms and Pathology (2014) (33)
- Selective Ablation of Lung Epithelial IKK2 Impairs Pulmonary Th17 Responses and Delays the Clearance of Pneumocystis (2013) (32)
- Real-time Imaging Reveals That P2Y2 and P2Y12 Receptor Agonists Are Not Chemoattractants and Macrophage Chemotaxis to Complement C5a Is Phosphatidylinositol 3-Kinase (PI3K)- and p38 Mitogen-activated Protein Kinase (MAPK)-independent*♦ (2011) (32)
- Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition (2019) (32)
- The tumour suppressor CYLD regulates the p53 DNA damage response (2016) (32)
- Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis (2019) (31)
- The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts (2018) (31)
- NF-κB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma. (2016) (31)
- The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells (2014) (30)
- Transplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency. (2016) (30)
- Differential dependence of CD 4 CD 25 regulatory and natural killer-like T cells on signals leading to NF-B activation (2004) (30)
- Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth (2020) (29)
- Deletion of IKK 2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia / reperfusion injury (2005) (29)
- Endothelial and Macrophage-Specific Deficiency of P38α MAPK Does Not Affect the Pathogenesis of Atherosclerosis in ApoE−/− Mice (2011) (28)
- IKK2 Inhibition Attenuates Laser-Induced Choroidal Neovascularization (2012) (27)
- Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis (2017) (27)
- Epithelial Cell Death and Inflammation in Skin. (2015) (26)
- IκB Kinase α Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma. (2018) (26)
- Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity (2018) (25)
- ADAR1 averts fatal type I interferon induction by ZBP1 (2022) (25)
- OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis (2019) (23)
- Inhibitor κB Kinase β Deficiency in Primary Nociceptive Neurons Increases TRP Channel Sensitivity (2009) (21)
- Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B (2014) (20)
- Opposing role of tumor necrosis factor receptor 1 signaling in T cell–mediated hepatitis and bacterial infection in mice (2016) (19)
- M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. (2006) (19)
- Role of TNF in pathologies induced by nuclear factor kappaB deficiency. (2010) (18)
- Generalized immune activation as a direct result of activated CD4+ T cell killing (2009) (18)
- Correction: Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling (2013) (18)
- Prion propagation in mice lacking central nervous system NF-kappaB signalling. (2008) (18)
- RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury (2019) (17)
- Hepatocyte IKK2 Protects Mdr2−/− Mice from Chronic Liver Failure (2011) (17)
- NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis (2015) (16)
- RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation (2019) (16)
- The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression. (2018) (16)
- B kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NFk B in the central nervous system (2011) (14)
- OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice (2021) (14)
- NF-κB Essential Modulator (NEMO) Is Critical for Thyroid Function* (2016) (14)
- Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes (2018) (12)
- Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation (2021) (11)
- A 20 ( Tnfaip 3 ) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection (2012) (11)
- Inhibition of NF-kappa B activation in macrophages increases atherosclerosis in LDL receptor-deficient mice (2003) (10)
- NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation (2021) (10)
- Correction: Bacteria Regulate Intestinal Epithelial Cell Differentiation Factors Both In Vitro and In Vivo (2013) (9)
- Correction: A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection (2012) (8)
- Erratum: Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration (Journal of Clinical Investigation (2006) 116 (2945-2954) DOI:10.1172/JCI28721) (2007) (7)
- [70] DELETION OF NEMO/IKK-G IN LIVER PARENCHYMAL CELLS CAUSES STEATOHEPATITIS AND HEPATOCELLULAR CARCINOMA (2007) (6)
- Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF (2021) (6)
- Author response: Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis (2014) (6)
- Igλ+ B cell development but not Igκ editing depends on NF-κB signals (2009) (6)
- Making gene-modified mice. (2005) (5)
- Prion propagation in mice lacking central nervous system NFk B signalling (2008) (5)
- Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages (2021) (5)
- Connecting immune deficiency and inflammation (2018) (4)
- A way to DAI. (2012) (4)
- Mice Lacking Epithelial I-?B Kinase are Protected from Lipopolysaccharide and Cigarette Smoke Extract Induced Inflammation (2013) (4)
- Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity (2021) (4)
- CCR2+ monocytic-Myeloid Derived Immunosuppressive Cells (M-MDSC) inhibit collagen degradation and promote lung fibrosis by producing TGF-β1. (2017) (3)
- Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (2020) (3)
- Development of immunoglobulin k-chain – positive B cells , but not editing of immunoglobulin j-chain , depends on NF-j B signals (2009) (3)
- Correction: A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms (2020) (2)
- Leishmania guyanensis suppressed inducible nitric oxide synthase provoked by its viral endosymbiont (2022) (2)
- Erratum to “Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis” (1999) (2)
- Conditional Targeting of TRAF6 Reveals Opposing Functions of TLR Signaling in Endothelial and Myeloid Cells in a Mouse Model of Atherosclerosis (2012) (2)
- Non-Cooperative Interactions Between Transcription Factors and Clustered DNA Binding Sites Enable Graded Transcriptional Responses To Environmental Inputs (2010) (2)
- RIP kinase 3 in necroptosis: does it take two or more to kill? (2014) (2)
- NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK 1 Kinase Activity-Mediated Hepatocyte Apoptosis Graphical (2015) (2)
- LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L (2018) (1)
- Spontaneous inflammatory demyelinating disease intransgenic miceshowingcentral nervoussystem-specific expression oftumornecrosis factor a (autoimmunity/disease model/neuroimmunology/inflammatory/cytokine) (1995) (1)
- MK2 phosphorylates RIPK1 to prevent TNF induced cell death. Jaco et al (2017) (1)
- Genetically Modified Mice as a Tool to Study Inflammatory Skin Diseases (2004) (1)
- Conditional disruption of IkB kinase 2 fails to prevent obesity-induced insulin resistance (2018) (1)
- PS2-048. A20/TNFAIP3 in intestinal homeostasis and inflammation (2011) (1)
- 973 IKK/NF-κB signaling in keratinocytes controls TNF-dependent necroptosis- and apoptosis-mediated skin inflammation (2018) (1)
- NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition (2022) (1)
- NF-kappaB/IKK-2 Signalling Is Not Required For Cigarette Smoke-Induced Airway Inflammation (2012) (1)
- Concern over use of the term Z-DNA (2021) (1)
- Epithelial IKKα licenses ILC3s to defend the intestinal barrier (2015) (1)
- Short Communication Prion propagation in mice lacking central nervous system NF-kB signalling (2008) (1)
- NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer (2022) (1)
- ΙκΒ kinase α is required for development and progression of KRAS -mutant lung adenocarcinoma (2018) (1)
- 177 Critical Role of TNFR-Associated Death Domain (TRADD) in the Toll-Like Receptor (TLR)-Independent Antiviral Response (2007) (1)
- Recruitment, activation and function of monocytes/macrophage in skin wound healing (2016) (1)
- Correction: Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity (2018) (1)
- RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8 (2023) (0)
- Correction: A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms (2020) (0)
- Lipid signalling drives proteolytic rewiring of mitochondria by YME1L (2019) (0)
- Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis (2022) (0)
- Oligodendrocyte-Specific FADD Deletion (2010) (0)
- Abstract 3844: A novel liposomal Clodronate depletes tumor-associated macrophages in primary and metastatic melanoma: anti-angiogenic and anti-tumor effects (2016) (0)
- S11 Epithelial nuclear factor κB signaling controls mucosal immune responses to intestinal bacteria (2010) (0)
- A20 (TNFAIP3) deficiency in myeloid cells triggers rheumatoid arthritis (2011) (0)
- DOP085 Innate mesenchymal MyD88 signals promote spontaneous intestinal tumorigenesis (2018) (0)
- 334 Role of RIP kinase signalling in the development of skin inflammation in mice with keratinocyte-specific IKK deficiency (2016) (0)
- 087 Metabolic and stress kinase signaling control skin barrier function: Implications for diabetic skin complications (2017) (0)
- S277: HYPOFERREMIA CAUSED BY FERROPORTIN DOWNREGULATION IS REGULATED BY NFКB THROUGH HDAC-DEPENDENT MECHANISMS (2022) (0)
- A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain (2019) (0)
- Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages (2021) (0)
- Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023) (0)
- Transgenic Models of Tumor Necrosis Factor Mediated Disease (1993) (0)
- Characterization of Phagocytic Pattern Recognition Receptors in Drosophila melanogaster (2011) (0)
- IKK2 hepatocyte specific deletion accelerates the liver regeneration and enhances the innate immune response in mice (2008) (0)
- Pneumocystis Delays the Clearance of Impairs Pulmonary Th17 Responses and Selective Ablation of Lung Epithelial IKK2 (2013) (0)
- 117 Epidermal barrier dysfunction upon loss of Insulin/IGF-1R signaling is compensated by p38α Map kinase stress signaling (2016) (0)
- W12-IS-001 The role of NF-icB in atherosclerosis (2005) (0)
- Projects Cologne-DFG-funded Collaborative Research Center SFB TRR259-Forschung Kardiologie Uniklinik Köln (2020) (0)
- Central role of neuronal IkappaBalpha kinase (IKK) in cerebral ischemia (2005) (0)
- Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl (2018) (0)
- The Role of Tumour Necrosis Factor in Lymphoid Tissue Formation and Function (1997) (0)
- Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition (2019) (0)
- The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts (2018) (0)
- Ripk-Mediated Necroptosis Induces Inflammation and Bone Marrow Failure in Mice (2014) (0)
- Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis (2019) (0)
- O95 NF-κB-DEPENDENT AND INDEPENDENT ROLES OF NEMO (IKKg) IN THE DEVELOPMENT OF CHRONIC LIVER INFLAMMATION AND HCC (2014) (0)
- Distinct Cell-Specific TNFR1-Signaling Determines Liver Damage in Experimental Hepatitis (2016) (0)
- CD11b + CD103 - Sentinel DCs Relay a Tunable Antibacterial NFκB Response in Intestinal Epithelial Cells Via TNF (2020) (0)
- Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease (2019) (0)
- Abstract: P187 ENDOTHELIAL NF-KB INHIBITION PROTECTS MICE FROM ATHEROSCLEROSIS (2009) (0)
- Abstract 3307: Tissue Specific Effects of the Transcription Factor Nuclear Factor Kappa B on Myocardial Ischemic Injury (2009) (0)
- Immunity to virus infection (excluding retroviruses) (PP-025) (2010) (0)
- 103 Nemo triggers protective pathways during liver injury (2006) (0)
- Necroptosis In Vivo Are Viable and Protected from TNF-Induced Cutting Edge: RIPK1 Kinase Inactive Mice (2014) (0)
- 158 Study of the Role of FAS-associated Death Domain Protein FADD in Brain Pathology by Conditional Gene Inactivation (2007) (0)
- Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE−/− mice (2022) (0)
- Limbic NF-KB signalling controls stress-induced anxiety and antidepressant effects independently of the HPA axis (2010) (0)
- Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (2020) (0)
- Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation (2020) (0)
- 15 NF-κB can be activated by IKK-2 independent pathways in the liver (2004) (0)
- Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation (2020) (0)
- Mice carrying an endogenous deletion of the 3′ AU-rich region of the tumour necrosis factor gene: Pathological complications (1997) (0)
- p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation (2022) (0)
- WITHDRAWN: Hepatocyte-specific IKKy/NEMO expression determines the degree of liver injury (2007) (0)
- Abstract B14: Hematopoietic RIPK1 deficiency results in bone marrow failure due to apoptosis and RIPK3-mediated necroptosis. (2015) (0)
- Inhibition of NFk B activation in macrophages increases atherosclerosis in LDL receptor – deficient mice (2018) (0)
- IFNγ-Induced Necroptosis Contributes to Hematopoietic Stem and Progenitor Cell Death and Bone Marrow Failure (2016) (0)
- Role of the TNF/LT/receptor system in the development and function of secondary lymphoid organs (1997) (0)
- [44] IKK HEPATOCYTE SPECIFIC DELETION ALTERS CELL CYCLE PROGRESSION AFTER PARTIAL HEPATECTOMY (2007) (0)
- Abstracts of the 86th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) With contribution of the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e. V. (AGAH) (2020) (0)
- IKK2 hepatocyte specific deletion alters cell cycle progression during liver regeneration (2007) (0)
- IKK/NF-κB signalling in chronic inflammation (2009) (0)
- RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury (2019) (0)
- Regulatory role of TNF in experimental ocular inflammation (1998) (0)
- I k B kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF- k B in the central nervous system (2011) (0)
- Identification of novel therapeutic targets in mastocytosis : Inhibition of survival of neoplastic mast cells by targeting IAPs and TRAIL receptors (2011) (0)
- DemyelinationProtects Mice from Autoimmune-Mediated Oligodendrocyte-Specific FADD Deletion (2010) (0)
- Inducing Z-DNA overcomes immune checkpoint blockade resistance (2022) (0)
- 50 IKKγ but not IKKβ is essential for liver regeneration after partial hepatectomy (2004) (0)
- FADD- and RIPK3-mediated cell death ensures timely clearance of wound macrophages and promotes wound healing (2023) (0)
- 838 IKK-beta independent pathways can activate NF-KB in vivo and protect from liver injury (2003) (0)
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What Schools Are Affiliated With Manolis Pasparakis?
Manolis Pasparakis is affiliated with the following schools:
