Manuel Morales

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Manuel Morales is affiliated with the following schools: Hokkaido University, University of California, Berkeley, University of Chicago, University of California, San Francisco

Manuel Morales's AcademicInfluence.com Rankings

Manuel Morales

Physics

#4521

World Rank

#6201

Historical Rank

Biophysics

#145

World Rank

#155

Historical Rank

physics Degrees

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Physics

Manuel Morales's Degrees

PhD Biophysics University of California, Berkeley
Bachelors Physics University of California, Berkeley

Why Is Manuel Morales Influential?

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According to Wikipedia, Manuel Francisco Morales was a Honduran-born American biophysicist who did pivotal research on the molecular basis of muscle contraction. Scientific career In the 1950s at the Naval Medical Research Institute, Morales and Terrell Hill showed that the high energy of the terminal phosphate bond in ATP was due to electrostatic repulsion between the three phosphate groups, and he and Richard Podolsky measured the heat of hydrolysis for ATP cleavage, the fundamental energy currency of biological metabolism.

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Manuel Morales's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Segmental flexibility of the S-1 moiety of myosin. (1973) (207)
On the molecular weight of myosin. II. (1966) (206)
Application of a one-step procedure for measuring inorganic phosphate in the presence of proteins: the actomyosin ATPase system. (1977) (192)
Analytical description of the effects of modifiers and of enzyme multivalency upon the steady state catalyzed reaction rate (1953) (159)
The effect of structure-disrupting ions on the activity of myosin and other enzymes. (1966) (124)
Polarization of Tryptophan Fluorescence from Single Striated Muscle Fibers (1972) (113)
SPECIFICITY OF CREATINE IN THE CONTROL OF MUSCLE PROTEIN SYNTHESIS (1974) (107)
Creatine and the control of myosin synthesis in differentiating skeletal muscle. (1972) (99)
Annual Review of Biophysics and Bioengineering (1972) (92)
Fluctuations in polarized fluorescence: evidence that muscle cross bridges rotate repetitively during contraction. (1979) (85)
Molecular kinetics of muscle adenosine triphosphatase. (1952) (79)
On the molecular weight of myosin. (1958) (78)
Reciprocal reactivities of specific thiols when actin binds to myosin. (1976) (74)
On the mechanism of energy transduction in myosin subfragment 1. (1984) (67)
The enzymatic activity and inhibition of adenosine 5'-triphosphate-creatine transphosphorylase. (1960) (66)
Nitrogen-15 Nuclear Magnetic Resonance Evidence That Mg2+ Does Not Complex with Nitrogen Atoms of Adenosine Triphosphate (1966) (64)
Modifying preselected sites on proteins: the stretch of residues 633-642 of the myosin heavy chain is part of the actin-binding site. (1988) (64)
On the origin and transmission of force in actomyosin subfragment 1. (1989) (63)
Defining the "fast-reacting" thiols of myosin by reaction with 1, 5 IAEDANS. (1976) (63)
Kinetic properties and equilibrium constant of the adenosine triphosphate-creatine transphosphorylase-catalyzed reaction. (1961) (63)
Conformational changes in the molecular control of muscle contraction. (1969) (62)
Studies on the Contractile Proteins of Muscle. I. The ATP-Myosin B Interaction1,2 (1959) (57)
STUDIES ON BODY COMPOSITION II. THEORETICAL CONSIDERATIONS REGARDING THE MAJOR BODY TISSUE COMPONENTS, WITH SUGGESTIONS FOR APPLICATION TO MAN (1945) (55)
Flexibility of myosin rod, light meromyosin, and myosin subfragment-2 in solution. (1977) (55)
Proteolysis and the domain organization of myosin subfragment 1. (1984) (53)
On “High Energy Phosphate Bonds” of Biochemical Interest1 (1951) (51)
Polarization of tryptophan fluorescence in muscle. (1969) (51)
Functional transitions in myosin: formation of a critical salt-bridge and transmission of effect to the sensitive tryptophan. (1998) (50)
Individual states in the cycle of muscle contraction. (1972) (50)
4,4'-Bis (1-anilinonaphthalene 8-sulfonate) (bis-ANS): a new probe of the active site of myosin. (1977) (49)
Interaction of globular actin with myosin subfragments. (1971) (49)
The interaction of myosin with adenosine triphosphate. (1953) (49)
Some Physical Studies of the Contractile Mechanism in Muscle (1982) (48)
Effects of tryptic digestion on myosin subfragment 1 and its actin-activated adenosinetriphosphatase. (1982) (46)
On the theory of blood-tissue exchange of inert gases; validity of approximate uptake expressions. (1948) (45)
Time-dependent fluorescence depolarization and lifetime studies of myosin subfragment-one in the presence of nucleotide and actin. (1975) (45)
Studies of myosin conformation by fluorescent techniques. (1969) (44)
A model for the elementary process in muscle action. (1952) (44)
A reexamination of the effects of creatine on muscle protein synthesis in tissue culture (1980) (43)
Number and location of adenosine triphosphatase sites of myosin. (1970) (43)
On the myosin catalysis of ATP hydrolysis. (2004) (40)
Isolation and partial renaturation of proteolytic fragments of the myosin head. (1984) (40)
Correction for Onishi et al., Toward understanding actin activation of myosin ATPase: The role of myosin surface loops (2006) (39)
AN ANALOGUE COMPUTER INVESTIGATION OF CERTAIN ISSUES IN ENZYME KINETICS. (1964) (38)
The adenosine triphosphatase activity of myosin B treated with S-beta-aminoethylisothiuronium. (1960) (38)
Orientation of actin monomer in the F-actin filament: radial coordinate of glutamine-41 and effect of myosin subfragment 1 binding on the monomer orientation. (1988) (37)
On the molecular basis for chemomechanical energy transduction in muscle. (1979) (36)
Independent and cooperative reactions of myosin heads with F-actin in the presence of adenosine triphosphate. (1971) (35)
On the theory of blood-tissue exchanges: II. Applications (1944) (34)
EXPERIMENTAS ON THE MODIFICATION OF MYOSIN NUCLEOSIDETRIPHOSPHATASE. (1964) (33)
Fluctuations in tension during contraction of single muscle fibers. (1977) (32)
Early stages of energy transduction by myosin: Roles of Arg in Switch I, of Glu in Switch II, and of the salt-bridge between them (2002) (32)
The elastic mechanism and hydrogen bonding in actomyosin threads. (1951) (31)
Spectroscopic isolation of ES complexes of myosin subfragment-1 ATPase by fluorescence quenching. (1982) (30)
Affinity of myosin S-1 for F-actin, measured by time-resolved fluorescence anisotropy. (1976) (30)
Stabilization of a primary loop in myosin subfragment 1 with a fluorescent crosslinker. (1985) (29)
Calculation of the polarized fluorescence from a labeled muscle fiber. (1984) (29)
The myosin SH2-50-kilodalton fragment cross-link: location and consequences. (1988) (27)
Elementary processes in muscle action: an examination of current concepts. (1955) (27)
Studies on the kinetics and energetics of carbon and nitrogen metabolism of Chilomonas paramecium. (1948) (25)
Mechanisms of Muscle Contraction (1959) (25)
Some further observations on the interaction of EDTA with the myosin-ATP system. (1954) (24)
EVIDENCE FOR INTERACTION BETWEEN MAGNESIUM AND PURINE OR PYRIMIDINE RINGS OF 5'-RIBONUCLEOTIDES (1961) (23)
Exposure of actin thiols by the removal of tightly held calcium ions. (1985) (23)
Functional transitions in myosin: role of highly conserved Gly and Glu residues in the active site. (1997) (23)
Change in state of spin labels bound to sarcoplasmic reticulum with change in enzymic state, as deduced from ascorbate-quenching studies. (1974) (22)
The effect of certain sulfur compounds on the myosin B-ATP system. (1957) (22)
Transmission of force and displacement within the myosin molecule. (2004) (22)
Location of a contact site between actin and myosin in the three-dimensional structure of the acto-S1 complex. (1989) (21)
If an Enzyme-Substrate Modifier System Exhibits Non-competitive Interaction, then, in General, its Michaelis Constant is an Equilibrium Constant (1955) (20)
Hydrostatic Pressure and the Contractile System (1965) (19)
A Note on the Differential Equation of Simple Enzyme Kinetics (1955) (19)
Kinetic studies of the myosin-tripolyphosphate system. (1955) (18)
Light Scattering of Multicomponent Macromolecular Systems (1952) (18)
Spin-label studies of glycerinated muscle fibers. (1969) (18)
Myosin modification as studied by spin labeling. (1969) (18)
The distribution of tracer substrate in an enzyme-substrate system at equilibrium (1962) (18)
A closer look at energy transduction in muscle (2007) (17)
Functional roles of ionic and hydrophobic surface loops in smooth muscle myosin: their interactions with actin. (2001) (17)
Experimental Determinations of the Diffusion Coefficients of Gases through Water: Nitrogen and Argon (1955) (16)
CONFORMATIONAL CHANGES IN MYOSIN B AND ACTOMYOSIN INDUCED BY ATP. (1963) (16)
A note on limiting reactions and temperature coefficients. (1947) (16)
Investigation of the shape and size of myosin subfragment 1 using small-angle X-ray scattering. (1978) (16)
Perspectives of biological energy transduction (1987) (16)
Smooth Muscle Myosin (1998) (15)
A note on the physiological arrangement of tissues (1945) (15)
STOCHASTIC ASPECTS OF ENZYME INHIBITION. (1965) (14)
The physiological factors which govern inert gas exchange (1945) (14)
Some studies on the infrared absorption of the contractile system of skeletal muscle. (1951) (14)
The reaction between actomyosin and various nucleotides and phosphates as followed by ultraviolet absorption. (1951) (13)
A search for protein structural changes accompanying the contractile interaction. (1991) (13)
The putative actin-binding role of hydrophobic residues Trp546 and Phe547 in chicken gizzard heavy meromyosin. (1995) (13)
Studies on the Contractile Proteins of Muscle. II. Polymerization Reactions in the Myosin B System1,2 (1959) (13)
On the theory of blood-tissue exchanges: III. Circulation and inert-gas exchanges at the lung with special reference to saturation (1944) (13)
Toward a theory of muscle contraction (1972) (12)
On the tryptophan residue of smooth muscle myosin that responds to binding of nucleotide. (2000) (12)
ENZYMATIC MODIFICATION OF MYOSIN BY DISULFIDE EXCHANGE. (1965) (12)
Does a myosin cross bridge progress arm over arm on the actin filament (1973) (12)
Energetics and molecular mechanisms in muscle action. Part 1. Outline of a theory of muscle action, and some of its experimental basis (1953) (11)
Some further infrared absorption studies on the proteins of muscle. (1951) (11)
A fundamental form for the differential equation of colonial and organism growth (1942) (11)
Modification of the actin interface of skeletal myosin subfragment-1 by treatment with dibromobimane. (1986) (10)
On the Mechanism of Cardiac Glycoside Action: Stimulation of Myosin B Superprecipitation by Ouabain and Digoxin (1966) (10)
Application of the Dale-Eisinger analysis to proximity mapping in the contractile system. (1984) (9)
On how a myosin tryptophan may be perturbed. (1993) (9)
A guide to the muscle papers. (1975) (9)
Myosin B nucleoside triphosphatase in deuterium oxide. (1960) (9)
The behavior of free-weighted actomyosin threads under pressure. (1951) (8)
Creatine: a possible stimulus skeletal cardiac muscle hypertrophy. (1975) (8)
Consequences of placing an intramolecular crosslink in myosin S1. (2000) (8)
Some qualitative considerations on the mechanism of striated muscle contraction (1948) (8)
Equilibrium equations for a model of antibody-antigen combination. (1948) (7)
Studies on myosin catalysis and modification. (1970) (7)
On a possible mechanism for biological periodicity (1944) (7)
Smooth muscle myosin. Amino acid residues responsible for the hydrolysis of ATP. (1998) (6)
Effect of lysine methylation and other ATPase modulators on the active site of myosin subfragment 1. (1994) (6)
SOME THERMOANALYTIC STUDIES OF ORGAN AND WHOLE ANIMAL RESPIRATION (1943) (6)
Application of interferometry to myosin ATPase and ion binding (1962) (6)
States of myosin subfragment-1 studied by catalyzed ascorbate reduction of bound spin label. (1976) (6)
GENERAL DISCUSSION (1974) (5)
The use of polyacrylamide gel electrophoresis to study relations between the chains of myosin. (1979) (5)
Calculation of body composition. (1958) (5)
The thermodynamics of free energy transfer in certain models of muscle action. (1952) (5)
Some nutritional and excretional interactions and the growth of an organ or colony (1945) (4)
The enthalpy change of adenosine triphosphate hydrolysis. (1956) (4)
The ATPases of Muscle Proteins (1961) (4)
Fluorescence staining of glycerinated myofibrils with 1-anilino naphthalene-8-sulfonate. (1968) (4)
Asynchrony of labyrinthine receptors as a physical factor in motion sickness. (1946) (3)
A brief and subjective history of contractility (1995) (3)
Sources of the high energy content in energy-rich phosphates. (1950) (3)
Toward a theory of muscle contraction. (1972) (3)
Erratum: Toward understanding actin activation of myosin ATPase: The role of myosin surface loops (Proceedings of the National Academy of Sciences of the United States of America (April 18, 2006) 103,16 (6136-6141) DOI:10.1073/pnas.0601595103)) (2006) (3)
The general membrane equilibrium equation: Its simple derivation and some of its biological implications (1941) (2)
The sequence location of the actin metal. (1992) (2)
Changes in the 31P NMR spectrum of rabbit muscle myosin subfragment 1. MgADP with temperature. (2002) (2)
The Search for a Biological Energy Transducer (1989) (2)
Inferences from the equations used for describing the chemistry of contraction. (1982) (1)
Two kinds of transducer (1987) (1)
Catalyzed reaction as a first-order process. (1952) (1)
Approximate Configurational Partition Functions for Certain Aggregates of Spherical Molecules (1948) (1)
Conformation and displacement in muscle contraction. (1970) (1)
ENERGY TRANSFER IN MUSCLE CONTRACTION * (1974) (0)
The Search for a Biological Energy Transducer 1 (2006) (0)
Proceedings of Yamada Conference XI on Energy Transduction in ATPases : the Tonomura Memorial Symposium, Inter-University Seminar House of Kansai, Kobe, Japan, 27-31 May, 1985 (1988) (0)
To the paper " Purification of folate binding factor in normal umbilical cord serum " (0)
Inferences from the equations used chemistry of contraction (2016) (0)
A PHYSICAL THEORY OF ACID ANION DISPLACEMENT AND RECOVERY FOLLOWING EXERCISE (1944) (0)
SOME T H E R M O A N A L Y T I C STUDIES OF ORGAN AND WHOLE ANIMAL R E S P I R A T I O N BY MANUEL F. MORALES (2003) (0)
Comparative Biochemistry. A Comprehensive Treatise. Volume II. Free Energy and Biological Function. (1961) (0)
Orientation of actin monomer in the F-actin filament: radial coordinate of glutamine-41 and effect of myosin subfragment 1 binding on the monomer orientation [Erratum to document cited in CA109(1):2635d] (1988) (0)
The micromechanics of contraction. (1988) (0)
The myocardium-its biochemistry and biophysics. II. Biochemistry. The ATPases of muscle proteins. (1961) (0)
JEAN BOTTS, REIJI TAKASHI, PETER TORGERSON, TETSU HozuMI*, ANDRAS MUHLRADt, DOMINIQUE MORNET, (2016) (0)
Studies of functional amino acid residues in smooth muscle myosin : mutagenesis of actin binding site (2000) (0)
How it looks in muscle contraction. (1973) (0)
Asynchrony of Labyrinthine Receptors; A Physical Factor in Motion Sickness (1947) (0)
A salt-bridge critical for the structural changes in the hydrolytic transition of myosin. (1999) (0)
Some Optical Observations on the Interaction Between Acetyl Cholinesterase and Its Substrate (1954) (0)
The region in myosin S-1 that may be involved in energy transduction. (1993) (0)
Isolation andpartial renaturation ofproteolytic fragments ofthe myosin head (1984) (0)
Modifying pre selected sites on proteins application to the 634 642 segment of myosin s 1 heavy chain (1988) (0)
Emerging problems in contractility. (1978) (0)
GENERAL DISCUSSION (1974) (0)
Erratum: The putative actin-binding role of hydrophobic residues Trp546 and Phe547 in chicken gizzard heavy meromyosin (Proceedings of the National Academy of Sciences of the United States of America (December 19, 1995) 92:26 (11965-11969)) (1996) (0)
An attempt to detect phosphorylated myosin by ADP-ATP exchange. (1971) (0)
Modifying preselected sites onproteins: Thestretch ofresidues 633-642 ofthemyosin heavychain ispartoftheactin-binding site (peptide/ATPase/subfragment-1/fluorescence/complementaliness) (1988) (0)
Corrections -Conformational Changes in the Molecular Control of Muscle Contraction (1970) (0)
A hypothesis about myosin catalysis. (2003) (0)

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What Schools Are Affiliated With Manuel Morales?

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