Manuel Serrano
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Computer Science
Manuel Serrano's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)Manuel Serrano's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Hallmarks of Aging (2013) (9261)
- Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a (1997) (4862)
- A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 (1993) (3888)
- Cellular senescence: from physiology to pathology (2014) (1723)
- Role of the INK4a Locus in Tumor Suppression and Cell Mortality (1996) (1675)
- Cellular Senescence in Cancer and Aging (2007) (1565)
- Tumour biology: Senescence in premalignant tumours (2005) (1426)
- A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma (1995) (1205)
- A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity (2009) (1034)
- Senescence in tumours: evidence from mice and humans (2010) (1020)
- Cellular Senescence: Defining a Path Forward (2019) (1017)
- Programmed Cell Senescence during Mammalian Embryonic Development (2013) (983)
- The Ink4/Arf locus is a barrier for iPS cell reprogramming (2009) (973)
- Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. (1998) (948)
- The common biology of cancer and ageing (2007) (911)
- Sirt1 protects against high-fat diet-induced metabolic damage (2008) (902)
- p19ARF links the tumour suppressor p53 to Ras (1998) (688)
- Mutations and altered expression of p16INK4 in human cancer. (1994) (577)
- Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. (2010) (565)
- Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. (2003) (562)
- 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally (2002) (498)
- Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. (2009) (486)
- Delayed ageing through damage protection by the Arf/p53 pathway (2007) (463)
- A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. (2007) (463)
- Putting the stress on senescence. (2001) (439)
- Reprogramming in vivo produces teratomas and iPS cells with totipotency features (2013) (436)
- Tissue damage and senescence provide critical signals for cellular reprogramming in vivo (2016) (432)
- Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice (2008) (426)
- Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. (2011) (422)
- The power and the promise of oncogene-induced senescence markers (2006) (414)
- Inhibition of ras-induced proliferation and cellular transformation by p16INK4 (1995) (406)
- GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK (2014) (402)
- p53: Guardian of the Genome and Policeman of the Oncogenes (2007) (398)
- Tumor suppressors and oncogenes in cellular senescence☆ (2000) (381)
- Tumor susceptibility of p21(Waf1/Cip1)-deficient mice. (2001) (371)
- A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases (2008) (352)
- The tumor suppressor protein p16INK4a. (1997) (309)
- The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. (2004) (308)
- Pten positively regulates brown adipose function, energy expenditure, and longevity. (2012) (303)
- Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. (2006) (293)
- Mutations associated with familial melanoma impair p16INK4 function (1995) (288)
- Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1 * (2000) (286)
- Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect (2009) (263)
- SIRT1: recent lessons from mouse models (2010) (251)
- Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues (2012) (245)
- SIRT1 contributes to telomere maintenance and augments global homologous recombination (2010) (231)
- The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development (2000) (223)
- Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras (1999) (207)
- Oncogenicity of the developmental transcription factor Sox9. (2012) (206)
- Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. (1995) (203)
- A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases (2008) (201)
- Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d (1998) (199)
- Oncogenic activity of Cdc6 through repression of the INK4/ARF locus (2006) (196)
- Cloning and characterization of murine p16INK4a and p15INK4b genes. (1995) (195)
- Deletion of the p16 and p15 genes in human bladder tumors. (1995) (194)
- Cancer and ageing: convergent and divergent mechanisms (2007) (186)
- Identification and characterization of Cardiac Glycosides as senolytic compounds (2019) (177)
- G6PD protects from oxidative damage and improves healthspan in mice (2016) (172)
- PTEN in cancer, metabolism, and aging (2013) (170)
- A versatile drug delivery system targeting senescent cells (2018) (170)
- Histone macroH2A isoforms predict the risk of lung cancer recurrence (2009) (169)
- Robust, universal biomarker assay to detect senescent cells in biological specimens (2016) (159)
- Sirtuin 1 regulation of developmental genes during differentiation of stem cells (2010) (157)
- Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma (2016) (157)
- Mechanistic principles of chromatin remodeling guided by siRNAs and miRNAs (2008) (148)
- Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. (2004) (141)
- Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence (2009) (140)
- Cellular senescence limits regenerative capacity and allograft survival. (2012) (130)
- The Arf/p53 pathway in cancer and aging. (2008) (129)
- Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin. (2007) (127)
- TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence (2018) (127)
- The downregulation of the pro‐apoptotic protein Par‐4 is critical for Ras‐induced survival and tumor progression (1999) (124)
- Tumour biology: Policing of oncogene activity by p53 (2006) (123)
- p27Kip1 Directly Represses Sox2 during Embryonic Stem Cell Differentiation (2012) (123)
- Senescence promotes in vivo reprogramming through p16INK 4a and IL‐6 (2017) (122)
- The INK4a/ARF locus in murine tumorigenesis. (2000) (120)
- miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal (2010) (111)
- p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A (1996) (111)
- Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. (2012) (108)
- The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression (2011) (108)
- PTEN recruitment controls synaptic and cognitive function in Alzheimer's models (2016) (107)
- Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity (2020) (105)
- Tumour‐suppression activity of the proapoptotic regulator Par4 (2005) (105)
- An OFF-ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo. (2017) (104)
- Increased p53 activity does not accelerate telomere‐driven ageing (2006) (101)
- Anti‐aging activity of the Ink4/Arf locus (2009) (100)
- SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling (2014) (99)
- WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. (2009) (96)
- p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis. (2010) (96)
- The PTEN/NRF2 axis promotes human carcinogenesis. (2014) (95)
- Mutational effects on the p16INK4a tumor suppressor protein. (1995) (95)
- Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. (2007) (95)
- Hallmarks of aging: An expanding universe (2022) (94)
- PTEN mediates Notch-dependent stalk cell arrest in angiogenesis (2015) (88)
- EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours (2012) (87)
- Par‐4 inhibits Akt and suppresses Ras‐induced lung tumorigenesis (2008) (86)
- NOTCH pathway inactivation promotes bladder cancer progression. (2015) (86)
- Cold-Inducible RNA-Binding Protein Bypasses Replicative Senescence in Primary Cells through Extracellular Signal-Regulated Kinase 1 and 2 Activation (2009) (81)
- Activation of cyclin D1-kinase in murine fibroblasts lacking both p21Cip1 and p27Kip1 (2002) (81)
- Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells (2015) (80)
- Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma (2006) (80)
- Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys. (2015) (77)
- Resistance to viral infection of super p53 mice (2005) (77)
- Induction of senescence by oncogenic Ras. (2001) (76)
- SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency (2013) (76)
- The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine (2004) (76)
- Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas (1997) (75)
- The Senescent Side of Tumor Suppression (2005) (74)
- SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function (2014) (71)
- Dietary restriction: standing up for sirtuins. (2010) (70)
- Regulation of the tumor suppressor PTEN by SUMO (2012) (69)
- Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells (2011) (67)
- Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1) (2009) (66)
- Partial Loss of Rpl11 in Adult Mice Recapitulates Diamond-Blackfan Anemia and Promotes Lymphomagenesis. (2015) (66)
- Genetic inactivation of Par4 results in hyperactivation of NF‐κB and impairment of JNK and p38 (2003) (65)
- A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. (2017) (64)
- Nephrin deficiency activates NF-kappaB and promotes glomerular injury. (2009) (63)
- A novel nucleoprotein complex at a replication origin. (1990) (62)
- The chemistry of senescence (2019) (61)
- Crosstalk between PKCζ and the IL4/Stat6 pathway during T‐cell‐mediated hepatitis (2004) (60)
- Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. (2002) (60)
- Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway (2010) (59)
- Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer. (2013) (59)
- Limited Role of Murine ATM in Oncogene-Induced Senescence and p53-Dependent Tumor Suppression (2009) (57)
- Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence (2018) (57)
- Growth Inhibition by the Tumor Suppressor p33ING1 in Immortalized and Primary Cells: Involvement of Two Silencing Domains and Effect of Ras (2005) (56)
- Antiviral action of the tumor suppressor ARF (2006) (56)
- A Unified Nomenclature and Amino Acid Numbering for Human PTEN (2014) (55)
- Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes (2011) (55)
- Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes (2011) (55)
- Ghrelin requires p53 to stimulate lipid storage in fat and liver. (2013) (55)
- Increased dosage of tumor suppressors limits the tumorigenicity of iPS cells without affecting their pluripotency (2012) (55)
- The ink4a/arf Tumor Suppressors Cooperate with p21 cip1/waf in the Processes of Mouse Epidermal Differentiation, Senescence, and Carcinogenesis* (2001) (54)
- Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner. (2015) (54)
- SIRT1 stabilizes PML promoting its sumoylation (2011) (54)
- A High-Throughput Loss-of-Function Screening Identifies Novel p53 Regulators (2006) (53)
- SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53 (2010) (53)
- Restoration of energy homeostasis by SIRT6 extends healthy lifespan (2021) (53)
- Genomic instability in iPS: time for a break (2011) (52)
- Regulation of mature T lymphocyte proliferation and differentiation by Par‐4 (2003) (52)
- Free [NADH]/[NAD(+)] regulates sirtuin expression. (2011) (50)
- A New Mechanism of Inactivation of the INK4/ARF Locus (2006) (49)
- Tumor Suppressor p53 Mediates Apoptotic Cell Death Triggered by Cyclosporin A* (2002) (48)
- Lysosomal trapping of palbociclib and its functional implications (2019) (48)
- Signals at the bacteriophage phi 29 DNA replication origins required for protein p6 binding and activity. (1989) (48)
- p73beta-Mediated apoptosis requires p57kip2 induction and IEX-1 inhibition. (2005) (47)
- Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-κB activation and invasive prostate carcinoma (2009) (47)
- Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis. (2007) (47)
- In Vivo Inhibition of c-MYC in Myeloid Cells Impairs Tumor-Associated Macrophage Maturation and Pro-Tumoral Activities (2012) (46)
- Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge. (2013) (46)
- Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia (2014) (46)
- Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic. (2020) (45)
- Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells (2012) (44)
- Inactivation of imprinted genes induced by cellular stress and tumorigenesis. (2005) (44)
- Cancer regression by senescence. (2007) (43)
- Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells (2017) (43)
- Cloning and characterization of murine p16(INK4a) and p15(INK4b) genes (1995) (43)
- Reprogramming activity of NANOGP8, a NANOG family member widely expressed in cancer (2014) (42)
- Genomic profiling of circulating plasma RNA for the analysis of cancer. (2007) (40)
- Acetylation is indispensable for p53 antiviral activity (2011) (40)
- Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression (2007) (40)
- Impact papers on aging in 2009 (2010) (40)
- Shifting senescence into quiescence by turning up p53 (2010) (40)
- Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2 (2002) (39)
- Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16INK4 (1996) (39)
- NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation (2016) (39)
- The pluripotency factor NANOG promotes the formation of squamous cell carcinomas (2015) (38)
- Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice (2004) (37)
- A functional link between the tumour suppressors ARF and p33ING1 (2006) (37)
- Superhelical path of the DNA in the nucleoprotein complex that activates the initiation of phage phi 29 DNA replication. (1993) (37)
- Specific Contribution of p19ARF to Nitric Oxide-Dependent Apoptosis1 (2006) (37)
- Interaction of the bacteriophage phi 29 protein p6 with double-stranded DNA. (1988) (37)
- Rplp1 bypasses replicative senescence and contributes to transformation. (2009) (36)
- AAV vector-mediated in vivo reprogramming into pluripotency (2018) (35)
- Regulation of the INK4a/ARF Locus by Histone Deacetylase Inhibitors* (2005) (35)
- Multimeric complexes formed by DNA-binding proteins of low sequence specificity. (1993) (34)
- Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers (2016) (34)
- Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline (2015) (34)
- Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis (2017) (34)
- Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas. (1999) (33)
- Impact of Sirt1 on mammalian aging (2010) (33)
- Cancer: A lower bar for senescence (2010) (33)
- In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice (2020) (33)
- Dissecting the role of mTOR complexes in cellular senescence (2012) (32)
- A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activity (2011) (32)
- p16INK4 mutations and altered expression in human tumors and cell lines. (1994) (28)
- Activation of Replication Origins in φ29-related Phages Requires the Recognition of Initiation Proteins to Specific Nucleoprotein Complexes* (1996) (28)
- Protein-nucleic acid interactions in bacteriophage phi 29 DNA replication. (1995) (28)
- Transcription activation at a distance by phage phi 29 protein p4. Effect of bent and non-bent intervening DNA sequences. (1991) (28)
- Sirt4: the glutamine gatekeeper. (2013) (28)
- MSK2 Inhibits p53 Activity in the Absence of Stress (2009) (28)
- Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy (2015) (28)
- Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases (2020) (27)
- Senescence helps regeneration. (2014) (27)
- Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging (2013) (27)
- Analysis of p16INK4a and its interaction with CDK4. (1996) (27)
- Unraveling the links between cancer and aging. (2016) (27)
- Phage Ø29 protein p6: A viral histone-like protein (1994) (27)
- Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors. (1995) (27)
- Ing1 Mediates p53 Accumulation and Chromatin Modification in Response to Oncogenic Stress* (2007) (26)
- Cancer: Final act of senescence (2011) (25)
- Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway. (2014) (25)
- A new mouse model to explore the initiation, progression, and therapy (2007) (25)
- Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming (2022) (24)
- Troponin-I enhances and is required for oncogenic overgrowth (2016) (24)
- Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging (2018) (24)
- Targeting senescence (2018) (23)
- The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity (2018) (21)
- G6PD overexpression protects from oxidative stress and age‐related hearing loss (2020) (20)
- Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells. (2007) (20)
- PI3Kɑ inhibition reduces obesity in mice (2016) (19)
- The TRIP from ULF to ARF. (2010) (19)
- The p21Cip1 protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers (2002) (19)
- Limited role of Sirt1 in cancer protection by dietary restriction (2011) (17)
- Apoptosis, G1 Phase Stall, and Premature Differentiation Account for Low Chimeric Competence of Human and Rhesus Monkey Naive Pluripotent Stem Cells (2020) (17)
- Cellular Senescence in Lung Fibrosis (2021) (17)
- Cellular senescence is immunogenic and promotes anti-tumor immunity. (2022) (17)
- Engineering Cancer Resistance in Mice (2003) (17)
- A strategy to study tyrosinase transgenes in mouse melanocytes (2005) (17)
- Characterization of a DNA binding protein of bacteriophage PRD1 involved in DNA replication. (1990) (17)
- Exome sequencing of three cases of familial exceptional longevity (2014) (17)
- Sirt1 protects from K‐Ras‐driven lung carcinogenesis (2018) (16)
- Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins (2014) (16)
- A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence (2021) (16)
- Increased gene dosage of the Ink4/Arf locus does not attenuate atherosclerosis development in hypercholesterolaemic mice. (2012) (15)
- Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas. (2006) (14)
- Specific contribution of p19ARF to nitric oxide-dependent apoptosis (2007) (14)
- erratum: Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d (1998) (14)
- The Arf / p 53 Pathway in Cancer and Aging (2008) (14)
- Senescence and Cancer: In the Name of Immunosuppression. (2016) (13)
- DNA conformational change induced by the bacteriophage phi 29 connector. (1992) (13)
- RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness (2021) (13)
- Normal Proliferation and Tumorigenesis but Impaired Pancreatic Function in Mice Lacking the Cell Cycle Regulator Sei1 (2010) (12)
- p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα (2016) (12)
- SHP2: a new target for pro‐senescence cancer therapies (2015) (11)
- Proliferation: the cell cycle. (2003) (11)
- Transient exposure to miR‐203 enhances the differentiation capacity of established pluripotent stem cells (2020) (11)
- Impact papers on aging in 2009 - eScholarship (2010) (11)
- IFNα 2b induces apoptosis and proteasome-mediated degradation of p27Kip1 in a human lung cancer cell line (2001) (11)
- to constitutive MEK / MAPK mitogenic signaling Premature senescence involving p 53 and p 16 is activated in response (1998) (10)
- Dissection of two routes to naïve pluripotency using different kinase inhibitors (2021) (10)
- “Super p53” Mice Display Retinal Astroglial Changes (2013) (10)
- Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase (2020) (10)
- p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo (2017) (9)
- Ageing: Tools to eliminate senescent cells (2017) (9)
- The InflammTORy Powers of Senescence. (2015) (9)
- Transcription activation at a distance by phage ø29 protein p4 (1991) (9)
- Imaging Cancer in Mice by PET, CT, and Combined PET‐CT (2011) (8)
- MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation (2021) (8)
- Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation (2020) (8)
- Transcription regulation in Bacillus subtilis phage Φ29 (1991) (8)
- Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect (2009) (8)
- ArticleThe Atypical PKC-Interacting Protein p 62 Is an Important Mediator of RANK-Activated Osteoclastogenesis (2004) (7)
- Notching up a new therapeutic strategy for Non-Small Cell Lung Carcinoma (NSCLC) (2012) (7)
- [Biochemical characterization of the optic nerve in mice overexpressing the P53 gen. Oxidative stress assays]. (2008) (7)
- Networks of tumor suppressors (2000) (6)
- Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea (2021) (6)
- Glucose 6‐P dehydrogenase delays the onset of frailty by protecting against muscle damage (2021) (6)
- CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells (2017) (6)
- Mitochondrial Damage Induces Senescence with a Twisted Arm. (2016) (6)
- Natural killer cells act as an extrinsic barrier for in vivo reprogramming (2022) (6)
- Metformin and reprogramming into iPSCs (2012) (6)
- Identification of the gene immediately downstream of the murine INK4a/ARF locus (2001) (6)
- Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells (2020) (5)
- Glaucoma Genetics – Regulation of Cell Surviving and Death in the Retina (2011) (5)
- Abstract 922: Delta133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells (2017) (5)
- Understanding Aging (2017) (5)
- Nephrin Deficiency Activates NF- B and Promotes Glomerular Injury (2009) (5)
- Normal cellular senescence and cancer susceptibility in mice genetically deficient in Ras-induced senescence-1 (Ris1) (2007) (4)
- Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity (2022) (4)
- IFNalpha 2b induces apoptosis and proteasome-mediated degradation of p27Kip1 in a human lung cancer cell line. (2001) (4)
- SOX9 Triggers Different Epithelial to Mesenchymal Transition States to Promote Pancreatic Cancer Progression (2022) (4)
- Induction of senescence renders cancer cells highly immunogenic (2022) (4)
- Protein-primed replication of bacteriophage phi 29 DNA. (1988) (4)
- Meeting Report: Aging Research and Drug Discovery (2022) (4)
- Analysis of the advantages of cis reporters in optimized FACS‐Gal (2017) (4)
- Bladder cancer and the Notch pathway (2015) (4)
- p73 hhh -Mediated Apoptosis Requires p57 kip2 Induction and IEX-1 Inhibition (2005) (3)
- Phage phi 29 protein p6: a viral histone-like protein. (1994) (3)
- Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype (2022) (3)
- Nuclear reprogramming and the cancer genome (2013) (2)
- The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling (2022) (2)
- The lysosomal proteome of senescent cells contributes to the senescence secretome (2022) (2)
- The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2 (2022) (2)
- Advances in Brief Mutations in the p 16 @ ' @ 4 / MTS 1 / CDKN 2 , p 15 @ 4 B / MTS 2 , and p 18 Genes in Primary and Metastatic Lung Cancer ' (2006) (2)
- Manipulating the Mediator complex to induce naïve pluripotency (2020) (2)
- DNA structure in the nucleoprotein complex that activates replication of phage phi 29. (1994) (2)
- Induced Pluripotency: Generation of iPS Cells from Mouse Embryonic Fibroblasts (2011) (2)
- Induction of Balbiani ring puffing changes by sugars and alcohols in Chironomus thummi. (1990) (2)
- Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescence (2022) (2)
- Conservation of Aging and Cancer Epigenetic Signatures across Human and Mouse (2021) (2)
- Cancer Cell Viability in Pancreatic Cancer Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports (2013) (1)
- G6PD Overexpression Protects Mice Against Associated Oxidative Stress and Delays the Occurrence of Frailty (2016) (1)
- The RNA Polymerase II Fa ctor RPAP 1 Is Critical for Mediator-Driven Transcription and Cell Identity Graphical (2018) (1)
- Targeting Mitochondria to Control Ageing and Senescence (2023) (1)
- [The cell cycle and gene p53. An approach to molecular ophthalmology]. (2010) (1)
- Retraction: Oncogenic activity of Cdc6 through repression of the INK4/ARF locus (2017) (1)
- Cellular senescence limits acute lung injury induced by mechanical ventilation (2020) (1)
- Antiviral action of the tumor suppressor ARF Marı́a (2013) (1)
- The cell cycle and gene p53. An approach to molecular ophthalmology (2010) (1)
- Tumor and Stem Cell Biology Oncogenicity of the Developmental Transcription Factor Sox 9 (2012) (1)
- Deciphering the roadmap of in vivo reprogramming toward pluripotency (2022) (1)
- A novel microRNA-based strategy to expand the differentiation potency of stem cells (2019) (0)
- G6PD overexpression protects from oxidative stress and ameliorates ARHL progression (2019) (0)
- Association of Rat pl 5 INK 4 Blpl 6 INK 4 Deletions with Monosomy 5 in Kidney Epithelial Cell Lines but not Primary Renal Tumors 1 (2006) (0)
- Bmi1 puSHHes reprogramming (2011) (0)
- MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation (2021) (0)
- A novel redox cycle diverts cells from oncogene-induced senescence into cancer. (2021) (0)
- A NIR fluorescent probe for the detection of renal damage based on overrepresentation of alanine aminopeptidase enzyme. (2023) (0)
- Faculty Opinions recommendation of p63 deficiency activates a program of cellular senescence and leads to accelerated aging. (2005) (0)
- Impact papers on aging in 2009 Citation (2022) (0)
- 3182 – PHARMACOLOGICAL INHIBITION OF NEMO-LIKE KINASE RESCUES MTOR-MEDIATED TRANSLATION AND ERYTHROPOIESIS IN PRE-CLINICAL MODELS OF DIAMOND BLACKFAN ANEMIA (2019) (0)
- erratum Crystal structureof thecomplex of thecyclinD-dependent kinaseCdk 6 bound to the cell-cycle inhibitor p 19 INK 4 d (0)
- Mechanisms Underlying p53 Genetic Regulation of Vascular Endothelial Growth Factor (VEGF) and Brain Derived Neurotrophic Factor (BDNF) in Mice Retina (2010) (0)
- P16(Ink4) - an Specific Inhibitor of the Cdk4/Cyclin-D Kinase (1994) (0)
- Pharmacological Inhibition of Nlk (Nemo-like Kinase) Rescues Erythropoietic Defects in Pre-Clinical Models of Diamond Blackfan Anemia (2018) (0)
- The role of inflammation mediated by MKP1 in age-related hearing loss (2017) (0)
- Metformin Upregulates Mir-26a to Improve Erythropoiesis in Preclinical Models of Diamond Blackfan Anemia through Suppression of Nlk Expression (2020) (0)
- Cancer Cell Previews Sirt 4 : The Glutamine Gatekeeper (2013) (0)
- Session 3: Cancer Prevention (2004) (0)
- Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia (2019) (0)
- Oxide-Dependent Apoptosis to NitricARFSpecific Contribution of p 19 Boscá and Sonsoles Hortelano (2006) (0)
- AAV vector-mediated in vivo reprogramming into pluripotency (2018) (0)
- Stem Cell Repor ts The trophectoderm acts as a niche for the inner cell mass through C/EBP a -regulated IL-6 signaling (2022) (0)
- Pseudoalignment tools as an efficient alternative to detect repeated transposable elements in scRNAseq data (2022) (0)
- The cell cycle and why is it important for oncology (2000) (0)
- Transcription regulation in Bacillus subtilis phage phi 29. (1991) (0)
- Abstract SY11-03: Sirt1 transgenic and cancer models (2011) (0)
- Characterization ofa DNAbinding protein of bacteriophage PRD1involved inDNAreplication (1990) (0)
- Anti-obesity effect in mice and monkeys of partial inhibition of PI3K[alpha] (2018) (0)
- Recent insights into the crosstalk between senescent cells and CD8 T lymphocytes (2023) (0)
- Prognostic significance of mediastinal node level invasion in non small cell lung cancer (1991) (0)
- Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8 (cid:1) T cells (2007) (0)
- Faculty Opinions recommendation of Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. (2005) (0)
- Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19 (2021) (0)
- Keep calm and transcribe on: chromatin changes with age, but transcription can learn to live with it (2022) (0)
- Intercellular Signaling in Cardiovascular Development and Disease Group, Centro Nacional de Investigaciones Cardiovasculares, (2015) (0)
- Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase (2020) (0)
- Abstract B45: A cell-based screening to identify nucleolar disruptors in cancer cells (2013) (0)
- Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis and iron homeostasis (2021) (0)
- Author Correction: Identification and characterization of Cardiac Glycosides as senolytic compounds (2020) (0)
- Oxide-Dependent Apoptosis to Nitric ARF Specific Contribution of p19 (2011) (0)
- The Serine Threonine Kinase Inhibitor Ots-167 Improves Erythropoiesis through Suppression of Nlk Activity in Diamond Blackfan Anemia Models (2021) (0)
- Senescence as a therapeutic target (2022) (0)
- Cellular senescence enhances adaptive anticancer immunosurveillance (2022) (0)
- Is a New Marker of Cellular Senescence That Regulates p 53 Activity and the Phosphoinositide 3-Kinase / AKT Pathway (2009) (0)
- A humanized animal model of pulmonary fibrosis based on cellular senescence (2020) (0)
- Author Correction: The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. (2023) (0)
- Primate naïve pluripotent stem cells stall in the G1 phase of the cell cycle and differentiate prematurely during embryo colonization (2020) (0)
- Targeting senescence (2018) (0)
- 706 Altered Expression of Sirtuin-1 or Its Inhibitor Deleted in Breast Cancer-1 Affects Premalignant Changes in Mouse Exocrine Tissue and Growth of Human Pancreatic Ductal Adenocarcinoma Cells (2012) (0)
- 300. AAV Vector-Mediated In Vivo Reprogramming of Various Cell Types in Adult Mice (2015) (0)
- SIRTI is not required for the beneficial effects of resveratrol treatment on insulin sensitivity in diabetic mice (2014) (0)
- Pre-cancer: From diagnosis to intervention opportunities. (2023) (0)
- Correction: Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress (2021) (0)
- Overexpression of G6PD as a model of robustness (2018) (0)
- The role of p27kip1 in the development, differentiation and maturation of mesencephalic dopaminergic neurons. (2018) (0)
- Abstract IA09: A drug delivery method selective for senescent cells (2016) (0)
- P19INK4D/CDK6 COMPLEX (1999) (0)
- Young and Lean: Elimination of Senescent Cells Boosts Adaptive Thermogenesis. (2017) (0)
- Tumor and Stem Cell Biology Oncogenicity of the Developmental Transcription Factor Sox9 (2012) (0)
- Recent progress on the mechanisms of aging and its medical applications (2019) (0)
- Faculty Opinions recommendation of Temporal dissection of p53 function in vitro and in vivo. (2005) (0)
- Have you seen ? SHP 2 : a new target for pro-senescence cancer therapies (2015) (0)
- 79: WNT16B, a new biomarker of senescent cells in vitro and in vivo, is necessary for the p53-dependent activation of p21WAF1 in cellular senescence (2010) (0)
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What Schools Are Affiliated With Manuel Serrano?
Manuel Serrano is affiliated with the following schools: