Marc G. Caron

Q: What Schools Are Affiliated With Marc G. Caron

Marc G. Caron is affiliated with the following schools: Yale University, Stanford University, Lund University, University of North Carolina at Chapel Hill, University of Miami, Duke University, Université Laval

Marc G. Caron's AcademicInfluence.com Rankings

Marc G. Caron

Biology

#1807

World Rank

#2931

Historical Rank

Neuroscience

#137

World Rank

#145

Historical Rank

biology Degrees

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Biology

Marc G. Caron's Degrees

PhD Pharmacology University of North Carolina at Chapel Hill
Bachelors Pharmacy University of North Carolina at Chapel Hill

Why Is Marc G. Caron Influential?

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According to Wikipedia, Marc G. Caron was a Canadian-born American researcher and James B. Duke Professor of Cell Biology at Duke University. He was one of the top highly cited researchers according to webometrics. Caron died on April 25, 2022, aged 75.

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Marc G. Caron's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Dopamine receptors: from structure to function. (1998) (3350)
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter (1996) (2422)
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. (1999) (1456)
Model systems for the study of seven-transmembrane-segment receptors. (1991) (1266)
Turning off the signal: desensitization of β‐adrenergic receptor function (1990) (1233)
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin (1986) (1137)
beta-Arrestin: a protein that regulates beta-adrenergic receptor function. (1990) (1127)
Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia (1999) (1047)
Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization (1996) (975)
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior (2005) (954)
Enhanced morphine analgesia in mice lacking beta-arrestin 2. (1999) (929)
Plasma membrane monoamine transporters: structure, regulation and function (2003) (917)
Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. (1999) (856)
Desensitization of G protein-coupled receptors and neuronal functions. (2004) (843)
Cloning and expression of a functional serotonin transporter from rat brain (1991) (789)
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. (2004) (785)
Recent advances in the molecular biology of dopamine receptors. (1993) (768)
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence (2000) (755)
Profound neuronal plasticity in response to inactivation of the dopamine transporter. (1998) (689)
Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. (1988) (670)
Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. (1987) (662)
Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. (1992) (652)
Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis (2004) (652)
Molecular cloning and expression of the gene for a human D1 dopamine receptor (1990) (651)
Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter (1998) (644)
Differential Affinities of Visual Arrestin, βArrestin1, and βArrestin2 for G Protein-coupled Receptors Delineate Two Major Classes of Receptors* (2000) (611)
Regulation of transmembrane signaling by receptor phosphorylation (1987) (589)
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. (1986) (581)
The β2-adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis (1999) (576)
The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor (1988) (574)
Molecular characterization of the dopamine transporter. (1993) (570)
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. (1987) (569)
Beta-adrenergic receptors: biochemical mechanisms of physiological regulation. (1984) (567)
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins (2002) (564)
Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase* (1998) (558)
Association of β-Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization* (1999) (558)
Dopamine receptors and brain function (1996) (556)
A family of receptors coupled to guanine nucleotide regulatory proteins. (1987) (551)
Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. (1992) (537)
Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. (1998) (532)
Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. (1989) (525)
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. (1992) (516)
Akt/GSK3 signaling in the action of psychotropic drugs. (2009) (507)
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. (1988) (500)
Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. (1992) (495)
Cloning of the cDNA for the human beta 1-adrenergic receptor. (1987) (488)
Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation (1987) (485)
Hyperactivity and impaired response habituation in hyperdopaminergic mice. (2001) (480)
Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization* (1996) (479)
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins (1987) (472)
Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression (2005) (465)
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia (2003) (460)
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). (1987) (457)
Mice lacking the norepinephrine transporter are supersensitive to psychostimulants (2000) (456)
Molecular Determinants Underlying the Formation of Stable Intracellular G Protein-coupled Receptor-β-Arrestin Complexes after Receptor Endocytosis* (2001) (442)
Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility (2001) (442)
Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization. (1983) (436)
A β-Arrestin/Green Fluorescent Protein Biosensor for Detecting G Protein-coupled Receptor Activation* (1997) (429)
Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization (1988) (419)
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. (2000) (415)
The Akt-GSK-3 signaling cascade in the actions of dopamine. (2007) (397)
Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. (1988) (397)
Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. (1989) (394)
Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins. (1988) (392)
Cocaine self-administration in dopamine-transporter knockout mice (1998) (392)
Distribution of α2-adrenergic receptor subtype gene expression in rat brain (1994) (388)
Dopamine Transporter Is Required for In Vivo MPTP Neurotoxicity: Evidence from Mice Lacking the Transporter (1997) (382)
Beta-adrenergic receptor kinase: primary structure delineates a multigene family. (1989) (377)
Building a new conceptual framework for receptor heteromers. (2009) (376)
Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. (1991) (372)
Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. (1991) (371)
Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. (1990) (371)
Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. (1990) (370)
The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation* (2003) (367)
Identification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity (2004) (367)
Knockout of the Vesicular Monoamine Transporter 2 Gene Results in Neonatal Death and Supersensitivity to Cocaine and Amphetamine (1997) (364)
Monoamine transporters: from genes to behavior. (2003) (360)
Dopamine transporters and neuronal injury. (1999) (359)
A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration. (1994) (354)
Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. (2000) (351)
Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission. (1991) (351)
Cloning and functional characterization of a cocaine‐sensitive dopamine transporter (1991) (350)
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4 (2003) (348)
Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. (1988) (347)
Functional Interaction between Monoamine Plasma Membrane Transporters and the Synaptic PDZ Domain–Containing Protein PICK1 (2001) (345)
Role of GSK3β in behavioral abnormalities induced by serotonin deficiency (2008) (345)
Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. (1975) (343)
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior (2008) (341)
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. (1996) (339)
Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release. (1978) (338)
Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling. (1988) (334)
Food Reward in the Absence of Taste Receptor Signaling (2008) (333)
Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems. (1992) (330)
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. (1995) (326)
Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate. (1993) (325)
Cocaine self-administration in dopamine-transporter knockout mice (1998) (325)
Antagonism of dopamine D2 receptor/β-arrestin 2 interaction is a common property of clinically effective antipsychotics (2008) (322)
Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. (1984) (322)
Discovery of β-Arrestin–Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy (2011) (316)
Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. (1994) (316)
G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. (1991) (303)
Dopamine receptor subtypes: beyond the D1/D2 classification. (1990) (295)
The Interaction of β-Arrestin with the AP-2 Adaptor Is Required for the Clustering of β2-Adrenergic Receptor into Clathrin-coated Pits* (2000) (294)
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. (1985) (293)
Rapid Alterations in Corticostriatal Ensemble Coordination during Acute Dopamine-Dependent Motor Dysfunction (2006) (290)
N-Desalkylquetiapine, a Potent Norepinephrine Reuptake Inhibitor and Partial 5-HT1A Agonist, as a Putative Mediator of Quetiapine's Antidepressant Activity (2008) (289)
MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction (2009) (284)
Role of phosphorylation in desensitization of the β-adrenoceptor (1990) (284)
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases (1992) (282)
Oligomerization and Trafficking of the Human Dopamine Transporter (2003) (281)
Differential Regulation of the Dopamine D2and D3 Receptors by G Protein-coupled Receptor Kinases and β-Arrestins* (2001) (281)
Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. (1990) (281)
Dopaminergic Control of Sleep–Wake States (2006) (280)
Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. (1990) (279)
Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in βArrestin-2 Knock-Out Mice (2002) (276)
Role of Dopamine Transporter in Methamphetamine-Induced Neurotoxicity: Evidence from Mice Lacking the Transporter (1998) (276)
Behavioral and Neurochemical Effects of Wild-Type and Mutated Human α-Synuclein in Transgenic Mice (2002) (274)
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity (2011) (270)
Structure-Function Relationships (1991) (269)
Molecular mechanism of desensitization of the chemokine receptor CCR‐5: receptor signaling and internalization are dissociable from its role as an HIV‐1 co‐receptor (1997) (265)
High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. (1994) (265)
Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. (1985) (264)
Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis 1 Published on the World Wide Web on 27 January 1998. 1 (1998) (263)
Atypical Responsiveness of the Orphan Receptor GPR55 to Cannabinoid Ligands* (2009) (262)
Regulation of Akt Signaling by D2 and D3 Dopamine Receptors In Vivo (2007) (259)
Structure of the adrenergic and related receptors. (1989) (254)
Loss of autoreceptor functions in mice lacking the dopamine transporter (1999) (254)
Effector coupling mechanisms of the cloned 5-HT1A receptor. (1989) (250)
Increased Methamphetamine Neurotoxicity in Heterozygous Vesicular Monoamine Transporter 2 Knock-Out Mice (1999) (250)
Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. (1990) (250)
Prepulse Inhibition Deficits and Perseverative Motor Patterns in Dopamine Transporter Knock-Out Mice: Differential Effects of D1 and D2 Receptor Antagonists (2001) (247)
Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice (2001) (245)
Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides. (1976) (244)
Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. (1989) (243)
A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. (1997) (242)
Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. (1988) (237)
Mice Deficient for the Vesicular Acetylcholine Transporter Are Myasthenic and Have Deficits in Object and Social Recognition (2006) (235)
Molecular mechanisms of G protein-coupled receptor desensitization and resensitization. (1998) (232)
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. (1999) (227)
HIV‐1‐induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR‐5 co‐receptor (1997) (227)
Synergistic Regulation of β2-Adrenergic Receptor Sequestration: Intracellular Complement of β-Adrenergic Receptor Kinase and β-Arrestin Determine Kinetics of Internalization (1997) (226)
The dopamine transporter: A crucial component regulating dopamine transmission (1997) (226)
Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs (2014) (225)
Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus. (2001) (225)
Cellular Trafficking of G Protein-coupled Receptor/β-Arrestin Endocytic Complexes* (1999) (225)
Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice (2003) (223)
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. (1996) (223)
Functional hyperdopaminergia in dopamine transporter knock-out mice (1999) (221)
Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate. (1997) (220)
Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. (1990) (220)
Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor. (1990) (217)
Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. (1987) (216)
Ontogeny of D1a and D2 dopamine receptor subtypes in rat brain using in situ hybridization and receptor binding (1994) (214)
Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. (1992) (213)
Molecular cloning and expression of a high affinity l-proline transporter expressed in putative glutamatergic pathways of rat brain (1992) (212)
Glycine receptor β–subunit gene mutation in spastic mouse associated with LINE–1 element insertion (1994) (211)
Dopamine D5 receptor immunolocalization in rat and monkey brain (2000) (206)
Role of Phosphorylation in Agonist-promoted β2-Adrenergic Receptor Sequestration (1995) (204)
Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice (1999) (204)
Genetic animal models: focus on schizophrenia (2001) (204)
Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. (1991) (203)
Anterior Pituitary Hypoplasia and Dwarfism in Mice Lacking the Dopamine Transporter (1997) (202)
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins (1996) (202)
Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. (1993) (200)
Aberrant responses in social interaction of dopamine transporter knockout mice (2004) (196)
The Dopamine D2, but not D3 or D4, Receptor Subtype is Essential for the Disruption of Prepulse Inhibition Produced by Amphetamine in Mice (1999) (195)
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice (2003) (195)
Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor. (1994) (191)
The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. (1984) (189)
Control of Myocardial Contractile Function by the Level of β-Adrenergic Receptor Kinase 1 in Gene-targeted Mice* (1998) (187)
cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure. (1989) (187)
Molecular biology of α-adrenergic receptors: implications for receptor classification and for structure-function relationships (1991) (185)
Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. (1992) (185)
Phosphoinositide 3-kinase regulates β2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/β-arrestin complex (2002) (183)
Agonist-dependent Recruitment of Phosphoinositide 3-Kinase to the Membrane by β-Adrenergic Receptor Kinase 1 (2001) (182)
Dual Control of Dopamine Synthesis and Release by Presynaptic and Postsynaptic Dopamine D2 Receptors (2012) (181)
Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutant. (2004) (181)
Mutagenesis of the beta 2-adrenergic receptor: how structure elucidates function. (1992) (180)
Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions (2008) (180)
Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases (*) (1996) (180)
Increased MPTP Neurotoxicity in Vesicular Monoamine Transporter 2 Heterozygote Knockout Mice (1998) (179)
G protein-coupled receptor adaptation mechanisms. (1998) (178)
Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. (1991) (177)
Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase. (1987) (175)
Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol. (1975) (175)
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. (1983) (173)
Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology. (1994) (172)
Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter (2008) (172)
Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. (2004) (171)
Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. (1991) (171)
G Protein-coupled Receptor Kinase 3 (GRK3) Gene Disruption Leads to Loss of Odorant Receptor Desensitization* (1997) (170)
Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D3 receptors (2002) (169)
Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase (1986) (168)
The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin* (1998) (168)
Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. (1994) (167)
Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase. (1992) (167)
The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. (1987) (165)
Plasma Membrane Transporters of Serotonin, Dopamine, and Norepinephrine Mediate Serotonin Accumulation in Atypical Locations in the Developing Brain of Monoamine Oxidase A Knock-Outs (1998) (165)
The mammalian beta 2-adrenergic receptor: purification and characterization. (1984) (164)
Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. (1991) (163)
Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease (2009) (162)
Agonist-modulated palmitoylation of beta 2-adrenergic receptor in Sf9 cells. (1992) (161)
RNA Editing Induces Variation in Desensitization and Trafficking of 5-Hydroxytryptamine 2c Receptor Isoforms* (2004) (160)
Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. (1985) (158)
Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes. (1976) (156)
Following the trace of elusive amines (2001) (156)
The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor. (1995) (153)
The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse (2012) (152)
Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. (1994) (152)
Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells. (1987) (151)
Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles. (1983) (150)
Neuropathic Pain Activates the Endogenous κ Opioid System in Mouse Spinal Cord and Induces Opioid Receptor Tolerance (2004) (150)
Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. (1994) (150)
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. (1991) (150)
Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter (2001) (149)
Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. (1985) (148)
Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons (2003) (147)
The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2. (1993) (146)
Rab5 Association with the Angiotensin II Type 1A Receptor Promotes Rab5 GTP Binding and Vesicular Fusion* (2002) (145)
Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists. (1982) (144)
Skeletal muscle beta-adrenergic receptors: variations due to fiber type and training. (1984) (144)
A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation. (1991) (144)
The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. (1991) (144)
Regulation of adrenergic receptor function by phosphorylation (1986) (143)
Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition. (1993) (142)
Functional Interaction between Trace Amine-Associated Receptor 1 and Dopamine D2 Receptor (2011) (142)
GRK2: multiple roles beyond G protein-coupled receptor desensitization. (2012) (141)
Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter (1999) (141)
Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. (1988) (140)
Vmat2 Heterozygous Mutant Mice Display a Depressive-Like Phenotype (2007) (140)
Dopamine Neuronal Transport Kinetics and Effects of Amphetamine (1999) (140)
Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system. (1990) (139)
Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics (2012) (138)
OCD-Like Behaviors Caused by a Neuropotentiating Transgene Targeted to Cortical and Limbic D1+ Neurons (1999) (138)
Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. (1992) (136)
β-Arrestin/AP-2 Interaction in G Protein-coupled Receptor Internalization (2002) (136)
From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. (1992) (135)
Pharmacological Characterization of Membrane-Expressed Human Trace Amine-Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer cAMP Biosensor (2008) (135)
The ß-adrenergic receptor and adenylate cyclase (1976) (133)
A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP. (1990) (132)
The Multiple LIM Domain-Containing Adaptor Protein Hic-5 Synaptically Colocalizes and Interacts with the Dopamine Transporter (2002) (132)
Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: implications for alpha 2 receptor classification. (1990) (132)
Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2 (2006) (130)
Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions (2002) (128)
Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. (1997) (128)
The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. (1987) (127)
Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit. (1981) (126)
Identification of Drosophila Neuropeptide Receptors by G Protein-coupled Receptors-β-Arrestin2 Interactions* (2003) (125)
The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits. (2000) (125)
Dopaminergic inhibition of adenylate cyclase correlates with high affinity agonist binding to anterior pituitary D2 dopamine receptors (1984) (124)
Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration. (1991) (123)
Chromosomal organization of adrenergic receptor genes. (1990) (122)
Dopamine-Independent Locomotor Actions of Amphetamines in a Novel Acute Mouse Model of Parkinson Disease (2005) (122)
The Vesicular Acetylcholine Transporter Is Required for Neuromuscular Development and Function (2009) (121)
Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance* (2004) (121)
Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice (2014) (120)
Targeting of the Orphan Receptor GPR35 by Pamoic Acid: A Potent Activator of Extracellular Signal-Regulated Kinase and β-Arrestin2 with Antinociceptive Activity (2010) (119)
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors. (1986) (119)
Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor. (1997) (119)
Affinity chromatography of the beta-adrenergic receptor. (1979) (117)
Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter (2000) (117)
A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs. (1990) (117)
Comparative Studies of Molecular Mechanisms of Dopamine D2 and D3 Receptors for the Activation of Extracellular Signal-regulated Kinase* (2004) (116)
Potentiated Opioid Analgesia in Norepinephrine Transporter Knock-Out Mice (2000) (114)
Visualization of Dynamic Trafficking of a Protein Kinase C βII/Green Fluorescent Protein Conjugate Reveals Differences in G Protein-coupled Receptor Activation and Desensitization* (1998) (114)
G Protein-Coupled Receptor Kinase 2 in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis (2005) (113)
Catecholamine release and uptake in the mouse prefrontal cortex (2001) (113)
Monoamine transporter pharmacology and mutant mice. (2002) (113)
A Gαs DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons (2013) (113)
Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits (2015) (112)
PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors (2009) (112)
Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity. (1984) (112)
Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. (1991) (112)
Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice (2003) (112)
Agonist-dependent phosphorylation of the α2-adrenergic receptor by the β-adrenergic receptor kinase (1987) (112)
Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability (2018) (110)
Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor. (1988) (109)
Regulation of Adenylate Cyclase Coupled β-Adrenergic Receptors by β-Adrenergic Catecholamines (1976) (108)
Paradoxical Striatal Cellular Signaling Responses to Psychostimulants in Hyperactive Mice* (2006) (108)
Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties (2016) (108)
Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. (1992) (107)
Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression (2009) (106)
Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice (2012) (106)
Dysregulation of Dopamine Transporters via Dopamine D2 Autoreceptors Triggers Anomalous Dopamine Efflux Associated with Attention-Deficit Hyperactivity Disorder (2010) (106)
Properties of Secretin Receptor Internalization Differ from Those of the β2-Adrenergic Receptor* (1999) (105)
Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. (1985) (105)
beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation. (1988) (105)
Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes. (1987) (104)
Blood phosphatidylethanol as a marker of alcohol abuse: levels in alcoholic males during withdrawal. (1997) (103)
Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase. (1989) (103)
Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. (1984) (102)
Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4 (2004) (101)
Elimination of the Vesicular Acetylcholine Transporter in the Striatum Reveals Regulation of Behaviour by Cholinergic-Glutamatergic Co-Transmission (2011) (100)
Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways. (1988) (99)
Mutational Analysis of Gβγ and Phospholipid Interaction with G Protein-coupled Receptor Kinase 2* (2000) (98)
Mammalian beta-adrenergic receptors. Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains. (1984) (98)
A β-Arrestin Binding Determinant Common to the Second Intracellular Loops of Rhodopsin Family G Protein-coupled Receptors* (2006) (98)
Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. (1989) (98)
Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale. (2016) (98)
Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase (1983) (98)
Adrenergic receptors. Models for regulation of signal transduction processes. (1990) (97)
A Dopamine D1 Receptor-Dependent β-Arrestin Signaling Complex Potentially Regulates Morphine-Induced Psychomotor Activation but not Reward in Mice (2011) (96)
G‐protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal (2004) (94)
The Selective Serotonin-2A Receptor Antagonist M100907 Reverses Behavioral Deficits in Dopamine Transporter Knockout Mice (2004) (93)
Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. (1996) (92)
Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action (2012) (92)
Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. (1990) (92)
Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice. (2000) (92)
New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy (2017) (92)
Inhibition of the Dopamine D1 Receptor Signaling by PSD-95*♦ (2007) (91)
The beta 1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling. (1982) (90)
Uptake and Release of Norepinephrine by Serotonergic Terminals in Norepinephrine Transporter Knock-Out Mice: Implications for the Action of Selective Serotonin Reuptake Inhibitors (2004) (90)
Real-time Visualization of the Cellular Redistribution of G Protein-coupled Receptor Kinase 2 and β-Arrestin 2 during Homologous Desensitization of the Substance P Receptor* (1999) (90)
ß-Arrestin 2 Regulates Zebrafish Development Through the Hedgehog Signaling Pathway (2004) (88)
Trace Amine-Associated Receptors as Emerging Therapeutic Targets (2009) (88)
Increased rewarding properties of morphine in dopamine‐transporter knockout mice (2000) (88)
Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice. (2000) (87)
Hyperdopaminergia and NMDA Receptor Hypofunction Disrupt Neural Phase Signaling (2009) (87)
G Protein-coupled Receptor Kinase Regulates Dopamine D3 Receptor Signaling by Modulating the Stability of a Receptor-Filamin-β-Arrestin Complex (2005) (87)
Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. (1992) (86)
Mice lacking the dopamine transporter display altered regulation of distal colonic motility. (2000) (86)
An animal model of attention deficit hyperactivity disorder. (2000) (86)
Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor. (2007) (86)
Rod Vision Is Controlled by Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA (2011) (86)
Targeting β-arrestin2 in the treatment of l-DOPA–induced dyskinesia in Parkinson’s disease (2015) (85)
Novelty Seeking and Stereotypic Activation of Behavior in Mice with Disruption of the Dat1 Gene (2005) (84)
A role for Ni in the hormonal stimulation of adenylate cyclase (1985) (84)
Looking at lithium: molecular moods and complex behaviour. (2008) (84)
Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. (2002) (84)
Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress (2015) (83)
Control of hormone receptor levels and growth of 7,12-dimethylbenz(a)anthracene-induced mammary tumors by estrogens, progesterone and prolactin. (1977) (82)
Dopamine transporter‐dependent and ‐independent actions of trace amine β‐phenylethylamine (2004) (81)
Genetics of childhood disorders: XXIV. ADHD, part 8: hyperdopaminergic mice as an animal model of ADHD. (2001) (80)
Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies. (1976) (80)
Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2 (2005) (80)
Cloning and characterization of the opossum kidney cell D1 dopamine receptor: expression of identical D1A and D1B dopamine receptor mRNAs in opossum kidney and brain. (1993) (79)
Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. (1991) (79)
Local Knockdown of Genes in the Brain Using Small Interfering RNA: A Phenotypic Comparison with Knockout Animals (2007) (78)
From Genes to Behavior (2002) (78)
Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. (1991) (77)
Dysautonomia Due to Reduced Cholinergic Neurotransmission Causes Cardiac Remodeling and Heart Failure (2010) (77)
Experimental Genetic Approaches to Addiction (2002) (76)
Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells. (1987) (76)
Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter. (2006) (75)
Catecholamine receptors: structure, function, and regulation. (1993) (75)
G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. (1992) (75)
Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner (2011) (74)
Regulation of adrenergic receptor function by phosphorylation. (1986) (74)
The Dopamine Metabolite 3-Methoxytyramine Is a Neuromodulator (2010) (73)
Inhibition of the beta-adrenergic receptor kinase by polyanions. (1989) (73)
Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase. (2008) (72)
Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene (1999) (72)
Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice (2012) (72)
Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter. (1996) (72)
Novel Strains of Mice Deficient for the Vesicular Acetylcholine Transporter: Insights on Transcriptional Regulation and Control of Locomotor Behavior (2011) (72)
Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features. (1999) (70)
Purification and characterization of the human platelet alpha 2-adrenergic receptor. (1986) (69)
Protein kinase stimulation of a reconstituted cholesterol side chain cleavage enzyme system in the bovine corpus luteum. (1975) (69)
Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression (2013) (68)
Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. (1989) (68)
Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors. (1988) (68)
Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor (2015) (68)
Green fluorescent protein-tagged beta-arrestin translocation as a measure of G protein-coupled receptor activation. (2004) (67)
Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit. (1986) (66)
Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. (1991) (66)
Agonist binding promotes a guanine nucleotide reversible increase in the apparent size of the bovine anterior pituitary dopamine receptors. (1983) (66)
Regulation of Arrestin-3 Phosphorylation by Casein Kinase II* (2002) (66)
Bone histomorphometric and biomechanical abnormalities in mice homozygous for deletion of the dopamine transporter gene. (2000) (65)
Mechanism of action of hypothalamic hormones in the anterior pituitary gland and specific modulation of their activity by sex steroids and thyroid hormones. (1978) (65)
5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. (1991) (65)
beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin. (2002) (64)
Photoaffinity labelling of mammalian beta-adrenergic receptors: metal-dependent proteolysis explains apparent heterogeneity. (1983) (64)
G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. (2004) (63)
The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress. (2013) (63)
Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. (2011) (63)
The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling. (1983) (63)
Behavioral responses to social stress in noradrenaline transporter knockout mice: Effects on social behavior and depression (2002) (63)
Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain. (1983) (62)
Reduced expression of the vesicular acetylcholine transporter causes learning deficits in mice (2009) (62)
Pharmacological blockade of a β2AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model (2013) (62)
β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions (2017) (62)
Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe. (1984) (62)
Effect of Antidepressant Drugs in Mice Lacking the Norepinephrine Transporter (2006) (62)
Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model. (1991) (61)
Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. (1991) (61)
G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway* (2009) (61)
Silencing of the Constitutive Activity of the Dopamine D1B Receptor (1996) (61)
Intranigral administration of D2 dopamine receptor antisense oligodeoxynucleotides establishes a role for nigrostriatal D2 autoreceptors in the motor actions of cocaine. (1994) (60)
Effects of Serotonin and Slow-release 5-HTP on Gastrointestinal Motility in a Mouse Model of Depression. (2019) (60)
Agonist-Specific Regulation of δ-Opioid Receptor Trafficking by G Protein-Coupled Receptor Kinase and β-Arrestin (1999) (60)
Direct demonstration of impaired functionality of a purified desensitized beta-adrenergic receptor in a reconstituted system. (1984) (59)
Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function. (1994) (59)
Norepinephrine Transporter-Deficient Mice Exhibit Excessive Tachycardia and Elevated Blood Pressure With Wakefulness and Activity (2004) (59)
G Protein and β-Arrestin Signaling Bias at the Ghrelin Receptor* (2014) (58)
Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin (2006) (58)
125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors. (1982) (58)
Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin (2006) (58)
Agonist-dependent Recruitment of Phosphoinositide 3-Kinase to the Membrane by b-Adrenergic Receptor Kinase 1 A ROLE IN RECEPTOR SEQUESTRATION* (2001) (57)
Dissecting the Contribution of Individual Receptor Subunits to the Enhancement of N-methyl-d-Aspartate Currents by Dopamine D1 Receptor Activation in Striatum (2011) (57)
Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. (1999) (57)
Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. (1987) (57)
Novelty Seeking and Stereotypic Activation of Behavior in Mice with Disruption of the Dat1 Gene (2005) (57)
Assignment of the creatine transporter gene (SLC6A8) to human chromosome Xq28 telomeric to G6PD. (1995) (56)
Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice (2016) (56)
Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. (1997) (56)
Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase. (1982) (54)
Activity‐dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain (2008) (54)
Hypertension and Impaired Glycine Handling in Mice Lacking the Orphan Transporter XT2 (2004) (53)
Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase. (1990) (53)
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling. (1982) (52)
Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system. (1986) (52)
Optimizing the Temporal Resolution of Fast-Scan Cyclic Voltammetry. (2012) (52)
Photoaffinity labeling of the D2-dopamine receptor using a novel high affinity radioiodinated probe. (1985) (52)
Orphan Transporter SLC6A18 Is Renal Neutral Amino Acid Transporter B0AT3* (2009) (51)
Trace amine associated receptor 1 and movement control. (2008) (50)
The beta-adrenergic receptor: rapid purification and covalent labeling by photoaffinity crosslinking. (1982) (50)
Trafficking of the vesicular acetylcholine transporter in SN56 cells: a dynamin‐sensitive step and interaction with the AP‐2 adaptor complex (2002) (50)
Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice (2012) (50)
Quantitative Label-Free Phosphoproteomics Strategy for Multifaceted Experimental Designs (2011) (49)
A Role for Receptor Kinases in the Regulation of Class II G Protein-coupled Receptors (1998) (49)
Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. (2011) (49)
Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice (2010) (49)
Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice (2008) (49)
Adrenergic receptors: recent insights into their mechanism of activation and desensitization. (1993) (49)
Genetic regulation of beta-adrenergic receptors. (1989) (48)
Sex differences in response to chronic mild stress and congenital serotonin deficiency (2014) (48)
Food Reward in the Absence of Taste Receptor Signaling (2008) (48)
Identification, characterization, and molecular cloning of a novel transporter‐like protein localized to the central nervous system (1992) (48)
Norepinephrine-induced down regulation of alpha 1 adrenergic receptors in cultured rabbit aorta smooth muscle cells. (1983) (48)
Characterization of the desensitization properties of five dopamine receptor subtypes and alternatively spliced variants of dopamine D2 and D4 receptors. (2006) (48)
Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery. (2021) (48)
Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction (2005) (48)
Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase. (1975) (48)
Decreased ethanol preference and consumption in dopamine transporter female knock-out mice. (2002) (48)
Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. (1990) (47)
Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1. (1995) (47)
Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice (2009) (47)
Regulation of the β2‐adrenergic receptor and its mRNA in the rat ventral prostate by testosterone (1988) (47)
Purification and characterization of the D2-dopamine receptor from bovine anterior pituitary. (1988) (47)
Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go. (1993) (46)
The human placenta--a rich source of beta-adrenergic receptors: characterization of the receptors in particulate and solubilized preparations. (1980) (46)
Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet alpha 2-adrenergic receptor. (1989) (45)
Genetic NMDA Receptor Deficiency Disrupts Acute and Chronic Effects of Cocaine but not Amphetamine (2008) (45)
Identification of the D2‐‐Dopamine Receptor Binding Subunit in Several Mammalian Tissues and Species by Photoaffinity Labeling (1986) (45)
Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids (1996) (45)
Dopamine levels modulate the updating of tastant values (2007) (45)
Characterization of an Atypical Member of the Na+/Cl−‐Dependent Transporter Family: Chromosomal Localization and Distribution in GABAergic and Glutamatergic Neurons in the Rat Brain (1994) (45)
Photoaffinity labeling of the beta-adrenergic receptor. (1981) (45)
Role of phosphorylation in desensitization of the beta-adrenoceptor. (1990) (44)
Screening for Selective Ligands for GPR55 - Antagonists (2011) (44)
N-Aryl Piperazine Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators Possess Efficacy in Preclinical Models of NMDA Hypofunction and Cognitive Enhancement (2013) (44)
Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network* (2013) (44)
G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration. (1996) (44)
Noradrenergic Control of Cortico-Striato-Thalamic and Mesolimbic Cross-Structural Synchrony (2010) (44)
The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells. (2001) (43)
The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine (2013) (43)
Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions (2015) (43)
β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors (2020) (43)
The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C. (1989) (43)
An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits. (1994) (42)
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. (2012) (42)
Chimeric D2/D3 Dopamine Receptors Efficiently Inhibit Adenylyl Cyclase in HEK 293 Cells (1996) (42)
Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. (2009) (41)
Human dopamine transporter gene not linked to schizophrenia in multigenerational pedigrees. (1993) (41)
Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. (2000) (40)
Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps. (1983) (40)
Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor? (2009) (40)
Dopamine receptor of the porcine anterior pituitary gland. Solubilization and characterization. (1984) (40)
Molecular and regulatory properties of adrenergic receptors. (1987) (40)
Cocaine and amphetamine elicit differential effects in rats with a unilateral injection of dopamine transporter antisense oligodeoxynucleotides (1996) (40)
Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction. (2008) (40)
A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. (2006) (40)
Different sedimentation properties of agonist- and antagonist-labelled platelet alpha 2 adrenergic receptors. (1981) (39)
Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. (2013) (39)
Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. (2011) (39)
Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system. (1983) (38)
VNTR polymorphism for the human dopamine transporter gene (DAT1). (1993) (38)
Molecular cloning, stable expression and desensitization of the human dopamine D1b/D5 receptor. (1993) (38)
Guanine nucleotides regulate both dopaminergic agonist and antagonist binding in porcine anterior pituitary. (1982) (38)
Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells. (1985) (38)
No association between alleles or genotypes at the dopamine transporter gene and schizophrenia (1994) (38)
Phosphorylation and Desensitization of the Human -Adrenergic Receptor (1995) (37)
Heterogeneity of dopamine receptors. (1993) (37)
G Protein-Coupled Receptor Kinase Regulates Dopamine D3 Receptor Signaling By Modulating the Stability of a Receptor/Filamin/β-Arrestin Complex: A Case of Autoreceptor Regulation* (2005) (37)
β-Arrestin Goes Nuclear (2005) (37)
Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice (2005) (37)
Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors. (1998) (37)
Norepinephrine transporter knockout‐induced up‐regulation of brain alpha2A/C‐adrenergic receptors (2006) (36)
Dependence of Serotonergic and Other Nonadrenergic Enteric Neurons on Norepinephrine Transporter Expression (2010) (36)
Grk5l controls heart development by limiting mTOR signaling during symmetry breaking. (2013) (35)
International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? (2010) (35)
A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception (2011) (35)
A Regulatory Domain in the N Terminus of Tryptophan Hydroxylase 2 Controls Enzyme Expression* (2008) (35)
Novel roles for β‐arrestins in the regulation of pharmacological sequestration to predict agonist‐induced desensitization of dopamine D3 receptors (2013) (35)
Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. (1990) (35)
High affinity agonist binding to the dopamine D3 receptor: chimeric receptors delineate a role for intracellular domains. (1994) (35)
Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON l-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease (2008) (34)
The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation (2018) (34)
Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine (2015) (34)
Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. (1985) (33)
Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. (1998) (33)
Adrenergic receptors: molecular mechanisms of clinically relevant regulation. (1985) (33)
The new biology of drug receptors. (1989) (33)
MDMA “ecstasy” alters hyperactive and perseverative behaviors in dopamine transporter knockout mice (2004) (33)
β-Adrenergic receptors and rhodopsin: shedding new light on an old subject (1986) (32)
Cortical–Amygdalar Circuit Dysfunction in a Genetic Mouse Model of Serotonin Deficiency (2013) (32)
Dopamine receptor of the porcine anterior pituitary gland. Effects of N-ethylmaleimide and heat on ligand binding mimic the effects of guanine nucleotides. (1982) (32)
Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension (2006) (32)
Ontogeny of the striatal neurons expressing the D1 dopamine receptor in humans (1996) (32)
Norepinephrine transport-mediated gene expression in noradrenergic neurogenesis (2009) (32)
D1 Dopamine Receptor Binding and mRNA Levels Are Not Altered After Neonatal 6‐Hydroxydopamine Treatment: Evidence Against Dopamine‐Mediated Induction of D1 Dopamine Receptors During Postnatal Development (1993) (31)
Potent beta-adrenergic antagonist possessing chemically reactive group. (1980) (31)
Identification of the binding subunit of the D1-dopamine receptor by photoaffinity crosslinking. (1986) (31)
Hepatic &bgr;-arrestin 2 is essential for maintaining euglycemia (2017) (31)
Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase. (1986) (30)
Pleiotropic Role for GRKs and b-Arrestins in Receptor Regulation (1997) (30)
Application of microdialysis and voltammetry to assess dopamine functions in genetically altered (1999) (30)
Molecular biology of adrenergic receptors. (1988) (30)
Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. (2013) (30)
cDNA cloning and chromosomal localization of the human α‐adrenergic receptor kinase (1991) (30)
G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice. (2004) (30)
A murine model of hyperdopaminergic state displays altered respiratory control (2007) (30)
Chronic Fluoxetine Increases Extra-Hippocampal Neurogenesis in Adult Mice (2015) (30)
G protein-coupled receptor kinase/β-arrestin systems and drugs of abuse (2007) (30)
A Central Role for β-Arrestins and Clathrin-coated Vesicle-mediated Endocytosis in β2-Adrenergic Receptor Resensitization (1997) (29)
Genetic and genomic approaches to reward and addiction (2004) (29)
Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2. (1988) (29)
Purification and characterization of the beta-adrenergic receptor kinase. (1987) (29)
Novel adamantyl cannabinoids as CB1 receptor probes. (2013) (29)
Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine. (1984) (29)
Constitutive desensitization: a new paradigm for g protein-coupled receptor regulation. (2003) (29)
Noncanonical scaffolding of Gαi and β-arrestin by G protein–coupled receptors (2021) (29)
Homologous desensitization of the beta-adrenergic receptor. Functional integrity of the desensitized receptor from mammalian lung. (1985) (28)
Affinity chromatography of the anterior pituitary D2-dopamine receptor. (1986) (28)
Production of adrenergic receptors in yeast. (1996) (28)
Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships. (1991) (28)
Regulation of adenylate cyclase coupled beta-adrenergic receptors. (1976) (28)
Growth Arrest Specific 8 (Gas8) and G Protein-coupled Receptor Kinase 2 (GRK2) Cooperate in the Control of Smoothened Signaling* (2011) (28)
High inhibitory activity of a new antiestrogen, RU 16117 (11alpha-methoxy ethinyl estradiol), on the development of dimethylbenz(a)anthracene-induced mammary tumors. (1977) (27)
Human β 1- and β 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes (1988) (27)
Mechanisms involved in adrenergic receptor desensitization. (1990) (27)
ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. (2016) (27)
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis (2019) (27)
Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe. (1989) (27)
Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. (1999) (27)
Multiscale imaging characterization of dopamine transporter knockout mice reveals regional alterations in spine density of medium spiny neurons (2011) (26)
Clozapine‐, but not haloperidol‐, induced increases in ΔFosB‐like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors (2004) (26)
Beta-arrestin goes nuclear. (2005) (26)
Characterization of the radioiodinated analogue of SCH 23390: in vitro and in vivo D-1 dopamine receptor binding studies. (1988) (26)
Desensitization of DA1 dopamine receptors coupled to adenylyl cyclase in opossum kidney cells. (1991) (26)
Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter (2001) (26)
Integrated approaches to understanding antipsychotic drug action at GPCRs. (2014) (25)
hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia (2018) (25)
Dopamine receptors status after unilateral nigral 6-OHDA lesion. Autoradiographic and in situ hybridization study in the rat brain. (1993) (24)
Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin. (1999) (24)
Advancing drug discovery for schizophrenia (2011) (24)
Affinity chromatography of the D1 dopamine receptor from rat corpus striatum. (1988) (24)
Overlapping and Opposing Functions of G Protein-coupled Receptor Kinase 2 (GRK2) and GRK5 during Heart Development* (2014) (24)
Consideration of allosterism and interacting proteins in the physiological functions of the serotonin transporter. (2012) (24)
Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice (2014) (24)
Phosphorylation of the beta-adrenergic receptor accompanies catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. (1983) (24)
SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept (2016) (24)
Location and molecular cloning of D1 dopamine receptor (1992) (24)
D2 dopamine receptors in the human retina: Cloning of cDNA and localization of mRNA (1991) (24)
Temperature immutability of adenyl cyclase-coupled β adrenergic recptors (1974) (23)
Guanine nucleotides and alpha 1 adrenergic receptors in the heart. (1983) (23)
Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by molecular cloning. (1989) (23)
Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions (2014) (22)
Beta-Adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog erythrocyte membranes. (1976) (22)
Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin (2017) (22)
The mammalian beta-adrenergic receptor: structural and functional characterization of the carbohydrate moiety. (1987) (22)
A functional alternative splicing mutation in human tryptophan hydroxylase-2 (2010) (22)
Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions (2018) (21)
Affinity chromatography of human platelet α2-adrenergic receptors (1982) (21)
Genetic convergence during serial in vitro passage of a polyclonal squamous cell carcinoma. (1989) (21)
Functional interaction between Trace Amine Associated Receptor 1 ( TAAR 1 ) and dopamine D 2 receptor (2011) (21)
Detergents linked to polysaccharides: preparation and effects on membranes and cells. (1979) (21)
Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors (2019) (20)
N-Terminal amino acid sequence of rat tonin: homology with serine proteases. (1978) (20)
Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism. (1984) (20)
A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion (2019) (20)
Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating. (2020) (20)
Selective Deletion of GRK2 Alters Psychostimulant-Induced Behaviors and Dopamine Neurotransmission (2014) (20)
Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. (1974) (20)
Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. (1989) (20)
The role of GRK6 in animal models of Parkinson's Disease and L-DOPA treatment (2012) (20)
N-terminal Tyrosine Modulation of the Endocytic Adaptor Function of the β-Arrestins* (2007) (20)
DDD mice, a novel acute mouse model of Parkinson’s disease (2006) (20)
Potent inhibitory effect of a new antiestrogen (RU 16117) on the growth of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors. (1977) (20)
The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse (2014) (19)
A rapid and affordable screening platform for membrane protein trafficking (2015) (19)
Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization. (1989) (19)
Covalent labeling of the beta-adrenergic ligand-binding site with para-(bromoacetamidyl)benzylcarazolol. A highly potent beta-adrenergic affinity label. (1985) (19)
Solubilization of rat liver alpha 1-adrenergic receptors. Agonist specific alteration in receptor binding affinity. (1983) (19)
Interactions of Dopamine Receptors with G Proteins (1997) (18)
Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice (2013) (18)
Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness (2017) (18)
Dopamine D2 Receptor Relies upon PPM/PP2C Protein Phosphatases to Dephosphorylate Huntingtin Protein* (2014) (18)
Solubilization and Characterization of D2‐Dopamine Receptors in an Estrone‐Induced, Prolactin‐Secreting Rat Pituitary Adenoma (1986) (18)
Development of an affinity ligand for purification of alpha 2-adrenoceptors from human platelet membranes. (1984) (18)
Inactivation of the dopamine transporter reveals essential roles of dopamine in the control of locomotion, psychostimulant response, and pituitary function. (1998) (18)
Separation of solubilized alpha and beta adrenergic receptors by affinity chromatography. (1979) (18)
Binding of the opiate-like pentapeptide methionine-enkephalin to a particulate fraction from rat brain. (1976) (17)
GTPases in Biology II (1993) (17)
A novel radioiodinated high affinity ligand for the D2‐dopamine receptor (1984) (17)
Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity. (1995) (17)
Designing Functionally Selective Non-Catechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. (2019) (17)
Persistent Hyperdopaminergia Decreases the Peak Frequency of Hippocampal Theta Oscillations during Quiet Waking and REM Sleep (2009) (17)
Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience (2015) (17)
Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase. (1992) (16)
The dopamine transporter. The cloned target site of parkinsonism-inducing toxins and of drugs of abuse. (1996) (16)
Delineating muscarinic receptor functions. (1999) (16)
Deletion of Glycogen Synthase Kinase-3β in D2 Receptor–Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor–Dependent Synaptic Plasticity (2019) (16)
Photoaffinity labeling of turkey erythrocyte beta-adrenergic receptors: degradation of the Mr = 49,000 protein explains apparent heterogeneity. (1984) (16)
Correction: The Dopamine Metabolite 3-Methoxytyramine Is a Neuromodulator (2010) (15)
Brain-region-specific Molecular Responses to Maternal Separation and Social Defeat Stress in Mice (2018) (15)
Long-term exposure to ethanol increases the number and function of muscarinic M1 receptors in human neuroblastoma cells. (1996) (15)
Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates. (1999) (15)
Selective GPR35 Antagonists - Probes 1 & 2 (2010) (14)
Role of cyclic AMP in the actions of luteinizing hormone on steroidogenesis in the corpus luteum. (1978) (14)
The beta-adrenergic receptor and adenylate cyclase. (1976) (14)
Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity (2015) (14)
Synthesis of iodine-125 labeled (+/-)-15-(4-azidobenzyl)carazolol: a potent beta-adrenergic photoaffinity probe. (1983) (14)
Binding of [125I]-N-(p-aminophenethyl)spiroperidol to the D-2 dopamine receptor in the neurointermediate lobe of the rat pituitary gland: a thermodynamic study. (1988) (14)
Mechanisms of neuroprotection against ischemic insult by stress‐inducible phosphoprotein‐1/prion protein complex (2018) (14)
Identification of the Subunit Structure of Rat Pineal Adrenergic Receptors by Photoaffinity Labeling (1986) (14)
Photoaffinity labeling of β-adrenergic receptors in mammalian tissues (1984) (14)
Determining sources of fine-grained sediment for a reach of the Lower Little Bow River, Alberta, using a colour-based sediment fingerprinting approach (2017) (13)
Regulation of G protein-coupled receptors by agonist-dependent phosphorylation. (1990) (13)
Ghrelin receptor antagonism of hyperlocomotion in cocaine‐sensitized mice requires βarrestin‐2 (2018) (13)
A2a/D2 receptor interactions are not observed in COS-7 cells transiently transfected with dopamine D2 and adenosine A2a receptor cDNA. (1994) (13)
Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase. (1987) (13)
Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. (1988) (12)
Covalent labeling of the cerebral cortex alpha 1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe. (1983) (12)
Discovery of b-Arrestin Biased, Orally Bioavailable and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. (2019) (12)
Imidazole-derived agonists for the neurotensin 1 receptor. (2014) (12)
Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists. (2019) (12)
Dopamine transporter and vesicular monoamine transporter knockout mice : implications for Parkinson's disease. (2001) (12)
Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase). (1991) (12)
Molecular characterization of G-protein coupled receptors: isolation and cloning of a D1 dopamine receptor. (1991) (12)
The human D1A dopamine receptor gene promoter directs expression of a reporter gene to the central nervous system in transgenic mice. (1995) (12)
Phenotypic Regulation of the Sphingosine 1-Phosphate Receptor Miles Apart by G Protein-Coupled Receptor Kinase 2 (2015) (12)
Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE. (1995) (11)
A Brief History of the β-Arrestins. (2019) (11)
Elimination of GRK2 from Cholinergic Neurons Reduces Behavioral Sensitivity to Muscarinic Receptor Activation (2012) (11)
The guanine nucleotide regulatory protein-coupled receptors for nucleosides, nucleotides, amino acids and amine neurotransmitters. (1989) (11)
Modeling of sequestration and down regulation in cells containing beta2-adrenergic receptors. (1995) (11)
Center stage for the serotonin transporter: a gain-of-function polymorphism in persons with obsessive-compulsive disorder. (2003) (11)
Localization of the cDNA for an α1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13 (1994) (11)
Genetic mapping of the β-arrestin 1 and 2 genes on mouse Chromosomes 7 and 11 respectively (1995) (11)
Epidermal Growth Factor Promotes Uncoupling from Adenylyl Cyclase of the Rat D2S Receptor Expressed in GH4C1 Cells (1994) (11)
The Stem Cell-Expressed Receptor Lgr5 Possesses Canonical and Functionally Active Molecular Determinants Critical to β-arrestin-2 Recruitment (2013) (11)
Structure and function of the adrenergic receptor family. (1991) (11)
Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept (2019) (10)
Response to Correspondence: Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression (2005) (10)
Opposite function of dopamine D1 and N‐methyl‐D‐aspartate receptors in striatal cannabinoid‐mediated signaling (2011) (10)
The role of arrestins in development. (2013) (10)
Structure and function of beta-adrenergic receptors: regulation at the molecular level. (1984) (10)
Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines. (1976) (10)
Molecular characterization of dopamine receptors. (1990) (10)
Role of nitric oxide in ethanol-induced up-regulation of muscarinic acetylcholine receptors in SH-SY5Y cells. (2001) (9)
Dopamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (9)
Erratum: Identification and sequence of a binding site peptide of the β2-adrenergic receptor (Biochemistry (1988) 27, 6, (1813-1817)) (1988) (9)
Bringing Channels Closer to the Action! (2001) (9)
An Interaction between L-prostaglandin D Synthase and Arrestin Increases PGD2 Production* (2010) (9)
Orphan transporter SLC 6 A 18 is renal neutral amino acid transporter B 0 AT 3 (2009) (9)
Adrenergic receptors. (1988) (9)
Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors. (1984) (8)
Design, synthesis and biological evaluation of GPR55 agonists. (2017) (8)
Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands. (2017) (8)
Determination of the molecular size of frog and turkey erythrocyte .beta.-adrenergic receptors by radiation inactivation (1984) (8)
Selective GPR35 Antagonists - Probe 3 (2011) (8)
Biochemical properties of D1 and D2 dopamine receptors. (1988) (8)
Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin. (1987) (8)
Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes. (1988) (8)
The physiological relevance of functional selectivity in dopamine signalling. (2014) (8)
Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions (2015) (8)
Role of Dopamine Transporters in Neuronal Homeostasis (2009) (7)
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the , B-adrenergic receptor ( protein ldnase / refractoriness / 8-bromoadenosine 3 ' , 5 '-cyclic monophosphate / photoaffinity labeling ) (7)
Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs. (2019) (7)
Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies. (1985) (7)
CHAPTER 13 – Structure and Function of Adrenergic Receptors: Models for Understanding G Protein-Coupled Receptors (1990) (7)
Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans (2022) (7)
Synthetic peptides of the hamster P2-adrenoceptor as substrates and inhibitors of the 3-adrenoceptor kinase (2006) (7)
Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody. (1980) (7)
Structural, Functional, and Genetic Aspects of Receptors Coupled to G-Proteins (1992) (7)
Images in neuroscience. Molecular biology, II. A dopamine transporter mouse knockout. (1996) (7)
Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice (2015) (7)
Antibodies raised against purified β-adrenergic receptors specifically bind β-adrenergic ligands (1979) (6)
The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells. (1988) (6)
Recent molecular analyses of β-adrenergic receptor phosphorylation, sequestration and down regulation (1992) (6)
Reconstitution of the β-adrenergic receptor (2005) (6)
Signal transduction. Bringing channels closer to the action! (2001) (6)
Approaches to identify monoamine transporter interacting proteins (2005) (6)
Polymeric drugs by direct copolymerization: Polymer of β-adrenergic antagonist alprenolol and its binding to receptors and antibodies (1981) (6)
Reply to Belmaker et al.: GSK3β haploinsufficiency results in lithium-like effects in the forced-swim test (2008) (6)
Molecular mechanisms of beta-adrenergic receptor desensitization. (1987) (6)
The alpha 1C-adrenergic receptor: a new member in the alpha 1-adrenergic receptor family. (1990) (6)
Regulation of the Adenylate Cyclase Signalling Pathway: Potential Role for the Phosphorylation of the Catalytic Unit by Protein Kinase A and Protein Kinase C (1988) (6)
The chimaeras speak again (1993) (6)
Dopaminergic Receptors in the Anterior Pituitary Gland (2011) (5)
Affinity chromatography of human platelet alpha 2-adrenergic receptors. (1982) (5)
“To learn, you must pay attention.” Molecular insights into teachers' wisdom (2009) (5)
Identification of β-adrenergic receptors in rat hypothalamus (1977) (5)
Agonist-induced desensitization of the D-2 dopamine receptor in the intermediate lobe of the rat pituitary gland. (1988) (5)
Temperature immutability of adenyl cyclase-coupled beta adrenergic receptors. (1974) (5)
Constitutive Activity of Dopamine D1-Receptor Subtypes (1995) (5)
The Dopamine Transporter: Molecular Biology, Pharmacology and Genetics (2002) (5)
Biochemical characterization of the BETA-adrenergic receptor of the frog erythrocyte (1979) (5)
Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones. (2016) (5)
[Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation]. (1998) (5)
Erratum: Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet α2-adrenergic receptor (Biochemistry (1989) 28, 9, (4125-4130)) (1989) (5)
Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13. (1994) (4)
Transporter mediated regulation of neural communication (2003) (4)
Loss of β‐arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids (2020) (4)
Loss of β-arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids (2019) (4)
Triphenylmethane Dye Activation of Beta-Arrestin (2013) (4)
GENETIC REGULATION OF {3-ADRENERGIC RECEPTORS (1989) (4)
G-protein-coupled receptor genes as protooncogenes : Constitutively activating mutation of the a 1 B-adrenergic receptor enhances mitogenesis and tumorigenicity ( catecholam / tranformation / atherogenesis ) (4)
Molecular cloning, pharmacological characterization and genetic studies of the human dopamine transporter (1992) (4)
D2-dopamine receptor: biochemical characterization (1986) (4)
Effects of ethanol on phosphoinositide hydrolysis and muscarinic acetylcholine receptor number in SH-SY5Y cells. (2000) (4)
Identification and pharmacological properties of an antagonist of apelin receptors (2010) (4)
Molecular mechanism of desensitization of the chemokine receptor CCR‐5: receptor signaling and internalization are dissociable from its role as an HIV‐1 co‐receptor (2013) (4)
Biological activity of agarose-immobilized catecholamines. (1976) (3)
A mouse knockout (1996) (3)
Molecular mechanism of desensitization of the chemokine receptor CCR5 : receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor important in acute inflammatory responses (2013) (3)
Monoamine Transporters: Their Role in Maintaining Neuronal Homeostasis (2002) (3)
Selective KOP Receptor Agonists: Probe 1 & Probe 2 (2010) (3)
Biased agonists of the chemokine receptor CXCR3 differentially drive formation of Gαi:β-arrestin complexes (2020) (3)
Biased agonists of the chemokine receptor CXCR3 differentially drive formation of Gαi and β‐arrestin complexes (2020) (3)
Images in neuroscience. A mouse knockout. (1996) (3)
Membrane-Bound Hormone Receptors (1976) (3)
Desensitization of the β-Adrenergic Coupled Adenylate Cyclase. The β-Adrenergic Receptor Kinase Phosphorylates Agonist-Occupied Cyclase-Coupled Receptors (1987) (3)
Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine (2022) (3)
Biased Coupling to β-Arrestin of Two Common Variants of the CB2 Cannabinoid Receptor (2021) (3)
ENDOCRINE REVIEWS and the Peer-Review Process (1997) (3)
Catecholamine-induced Desensitization of Turkey Erythrooyte Adenylate Cyclase (1982) (3)
The Role of Receptor Kinases and Arrestin-Like Proteins in G-Protein-Linked Receptor Desensitization (1993) (3)
Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. (1986) (3)
The Dopamine Receptor of the Anterior Pituitary Gland: Ligand Binding and Solubilization Studies (1983) (3)
Chronic effects of ethanol on muscarinic acetylcholine receptors are modulated by protein kinase C (1999) (2)
The receptor kinase family: Primary structure of rhodopsin kinase reveals similarities to the f8-adrenergic receptor kinase (ganine protein-coupled receptors/desensitization/serine/threonine (2)
Molecular biology of adrenergic receptors in the rat and frog central nervous system. (1984) (2)
beta-adrenergic receptors in brown adipose tissue: identification by (-)[3H]dihydroalprenolol binding. (1978) (2)
Food for Thought: The Physiological Relevance of Ghrelin and Dopamine D2 Receptor Heterodimerization in the Regulation of Appetite (2012) (2)
HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase (2021) (2)
Cloning andexpression ofahumankidney cDNAforan a2-adrenergic receptor subtype (1988) (2)
Reconstitution of the beta-adrenergic receptor. (1985) (2)
Inhibition of the @-Adrenergic Receptor Kinase by Polyanions* (2001) (2)
Establishment of multi-stage intravenous self-administration paradigms in mice (2022) (2)
Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor. (1991) (2)
Partially Purified and Reconstituted G-Protein Coupled Receptors as Substrates of Specific Receptor Kinases (1994) (2)
Tyrosine phosphorylation of G protein a subunits by pp 6 Oc-src { guanosine 5 '-[ l-thio ] triphosphate binding / GTPase activity / stimulatory guanine nucleotide-binding regulatory protein a subunit ( H 2 la ) } (2)
DEVELOPMENT OF AN AFFINITY LIGAND FOR PURIFICATION OF α2-ADRENOCEPTORS FROM HUMAN PLATELET MEMBRANES (1984) (2)
Receptor-G Protein-Effector Coupling: Coding and Regulation of the Signal Transduction Process (1995) (2)
The adrenergic receptors. (1990) (2)
Selective KOP Receptor Antagonists: Probe 1 (2010) (2)
G Proteins and G Protein-Coupled Receptors (2002) (2)
1085 – Neuronal Serotonin As a Link Between Depression and Constipation: A Role for Simultaneous Treatment with a Novel Slow-Release Formulation of the Serotonin Precursor, 5-Hydroxytryptophan (2019) (2)
Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists) (2013) (2)
Structural biology: Antidepressants at work (2016) (2)
Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes (2022) (1)
Subject Index Vol. 52, 1989 (1989) (1)
PM435. Targeting Functional Selectivity of the Dopamine D2 Receptor for Treatment of Schizophrenia-like Behaviors (2016) (1)
Neurochemistry and Pharmacology of the Dopamine System in Mice Lacking Vesicular and Plasma Membrane Uptake Mechanisms (2003) (1)
Two Distinct Pathways for CAMP-mediated Down-regulation of the &-Adrenergic Receptor (2001) (1)
MOLECULAR CLONING AND EXPRESSION OF A NEW ALPHA-1-ADRENERGIC RECEPTOR SUBTYPE (1990) (1)
Molecular characterization of the β-adrenergic receptor of frog erythrocytes (1982) (1)
Dopamine: from pharmacology to molecular biology and back (2006) (1)
Synthesis of Iodine‐125 Labeled (±)‐15‐(4‐Azidobenzyl)carazolol: A Potent β‐Adrenergic Photoaffinity Probe. (1984) (1)
Identification of beta adrenergic receptors in rat hypothalamus. (1977) (1)
EDITORIAL: GENETIC MODELS IN PHARMACOLOGY: PRESENT STATUS AND FUTURE (1999) (1)
Measuring Nonapoptotic Caspase Activity with a Transgenic Reporter in Mice (2017) (1)
The β-Adrenergic Receptor:Elucidation of Its Molecular Structure (1985) (1)
Functional interaction between Trace Amine Associated Receptor 1 (TAAR1) and dopamine D2 receptor (2011) (1)
Adrenergic receptors. (1990) (1)
The mammalian beta-adrenergic receptors. (1989) (1)
Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands. (1979) (1)
11th Meeting on Adrenergic Mechanisms: Porto, Portugal 25–27 September 2003. Noradrenaline transporter knockout‐mediated regulation of serotonin receptors in mice brain (2003) (1)
The β-Adrenergic Receptor-Coupled Adenylate Cyclase: Reconstitution of the Functional Interactions of the Various Purified Components (1986) (1)
Structure of the human smoothened receptor in complex with ANTA XV (2014) (1)
D1 and D2 Dopamine Receptors: Identification by Photoaffinity Labeling and Purification by Affinity Chromatography (1988) (1)
Methylphenidate self-administration increases the potency and reinforcing effects of releasers through a dopamine transporter mechanism (2014) (1)
Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator (2022) (1)
Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice (2022) (1)
A Study Of The Cholesterol Side-Chain Cleavage Enzyme System In The Bovine Corpus Luteum (1973) (1)
Agonist-promoted desensitization and phosphorylation of. cap alpha. /sub 1/-adrenergic receptors coupled to stimulation of phosphatidylinositol metabolism (1986) (1)
Antibodies to the f 8-adrenergic receptor : Attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain ( adenylate cyclase-coupled receptor / immunocytochemical localization / radioimmunoassay ) (1)
f1-ADRENERGIC RECEPTORS (1988) (0)
Autoimmune Encephalomyelitis Multiple Sclerosis and Experimental G Protein-Coupled Receptor Kinase 2 in (2005) (0)
Identification of genes highly enriched in the mouse striatum (2003) (0)
Figure 1, GPR35 Example Images of Positive and Negative Controls (2011) (0)
834. Early Life Maternal Separation Stress Increases Vulnerability to Social Defeat Stress (2017) (0)
Ghrelin receptor signaling in health and disease: a biased view (2022) (0)
PL.01 Novel signalling paradigms in animal models (2006) (0)
Molecular properties of beta 1 adrenergic and beta 2 adrenergic receptors revealed by photo affinity labeling (1982) (0)
Comparative ratesofdesensitization of13-adrenergic receptors by thefJ-adrenergic receptor kinase andthecyclic AMP-dependent protein kinase (1991) (0)
Purification, characterization and reconstitution of the adenylate cyclase-coupled β-adrenergic receptor (1984) (0)
Figure 2, The GPR35 Antagonist Probe Flowchart summarizes the compound triage and decision tree for advancement of the compounds (2010) (0)
Figure 1, Previously reported GPR55 agonists (2011) (0)
Integrated Approaches to Understand the Actions of GPCRs: The b-Arrestin-Dependent D2R Mediated Signaling Through Akt/GSK3 (2014) (0)
S.20.03 β-Arrestin-dependent DAD2R/Akt/GSK3β signaling: relationship to mood stabilisers and antipsychotics (2008) (0)
Table 6, Receptor Paneling of KOP agonist Probes 1 [ML139] CID5236771 & 2 [ML138] CID44601470 through the PDSP (Bryan Roth, PI) (2010) (0)
[Table, Image Acquisition and Analysis]. (2011) (0)
A method for determining the receptor activity, and therefor useful constructs (1998) (0)
Figure 3, Downstream MAP Kinase Activation - Secondary functional assays for KOR agonist probes and selected analogs (2010) (0)
Table 6, Summary of in vitro ADMET/PK Properties of the GPR35 Antagonist Probes (2010) (0)
Additions and Corrections-Development of an Affinity Ligand for Purification of Adrenoceptors from Human Platelet Membranes (1984) (0)
Table 4, SAR of GPR55 Antagonist Probe ML192 (#2): CID1434953 (2011) (0)
Constitutive activity of dopamine D1-receptor subtypes. Discussion (1995) (0)
Demonstration of secretin receptor phosphorylation using a sensitive and specific receptor antisera (1998) (0)
Table 3, SAR for GPR35 Antagonist ML194 (3rd probe) (2011) (0)
Analysis procedures of receptor activity and constructs useful in such processes. (1998) (0)
Identification and sequence of a binding site peptide of the .beta.2-adrenergic receptor [Erratum to document cited in CA108(15):126956h] (1988) (0)
S.28.02 Influence of variants of TPH2 on the regulation of the central serotonin system (2006) (0)
Table 9, Comparative summary of two current probes CID5236771 & CID44601470 to literature examples (2010) (0)
Contents, Vol. 52, 1989 (1989) (0)
Following the trace of elusiv (2016) (0)
Isoproterenol enhances phosphorylation of pure β-adrenergic receptor by cAMP-dependent protein kinase (1984) (0)
Molecular properties of alpha 2 adrenergic receptors (1983) (0)
Table 8, Comparison of prior art and current probe (2010) (0)
Photoaffinity labeling of mammalian. cap alpha. /sub 1/-adrenergic receptors: identification of the ligand binding subunit with a high affinity radioiodinated probe. [Rats, guinea pigs, rabbits] (1984) (0)
Table 3, SAR Analysis for Selective κ–opioid receptor agonist for the Bisamide Scaffold (2010) (0)
Manifestation of dopamine and glutamate systems dysfunction in animal models of schizoid behavior (2000) (0)
Material for Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson ’ s Disease (2008) (0)
Cloning and expression of a human kidney cDNA for an a 2-adrenergic receptor subtype ( G protein / photoaffinity labeling / [ 3 Hjrauwolscine binding / a 2-adrenoceptor / a 2 B-adrenergc receptor ) (0)
Direct radioligand measurement of dopamine receptors in the anterior pituitary gland. (1983) (0)
Table 4, Probe and analog submission for Kappa Opioid Antagonists (2010) (0)
Phorbol esters promote a 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism ( smooth muscle / DDT , MF-2 cell line / catecholamines / afflinity chromatography / photoaffinity labeling ) (0)
Antibodies raised against purified fl-adrenergic receptors specifically bind f 3-adrenergic ligands ( agarose-alprenolol / affinity chromatography / catecholamines / immunogen / model receptor binding site ) (0)
Sediment fingerprinting in the Lower Little Bow River using Cs-137 as a tracer (2017) (0)
Secretin receptor tyrosine phosphorylation site mutation decreases receptor internalization (2001) (0)
Table 8, Comparative Downstream assays by Assay Provider for CID9581011 (2011) (0)
Figure 4c, Positive ion Mass Spectrum of ML194 (2011) (0)
β-arrestin Regulation of Ghrelin Signaling in modulating Addictive Behavior (2014) (0)
Terminalsat Vesamicol-Treated Motor Nerve Empty Synaptic Vesicles Recycle and Undergo (2015) (0)
[Table, Center summary of probe properties (solubility, absorbance/fluorescence, reactivity, toxicity, etc]. (2011) (0)
Table 5, Summary of in vitro ADMET/PK Properties of the GPR35 Antagonist Probe (2011) (0)
2009 Spring Colloquium Series The Margaret Bidwell Memorial Lecture (2009) (0)
[Figure], Primary Screen/Confirmation Triage (2010) (0)
Chapter 13 – Dopamine Receptors (2012) (0)
Structural basis of fi-adrenergic receptor subtype specificity studied with chimeric 81 / f 82-adrenergic receptors (0)
181. Manifestations of dopamine and glutamate systems dysfunction in animal models (2000) (0)
Secretin receptor internalization involves a mechanism distinct from clathrin-coated dependent endocytosis (1998) (0)
Immunohistochemical localization of dopamine (DA) receptors, dopamine transporter (DAT) and serotonin transporter (ST) in the mouse distal colon (2001) (0)
Expression of a G protein-coupled receptors in yeast. (1991) (0)
D2 Functionally Selective Ligands: Novel Therapeutics? (2013) (0)
Table 5B, Submission information on Probe#2: CID1542103 and analogs (2010) (0)
Receptor research: the past, the present and the outlook. (1991) (0)
cAMP stimulates transcription of the f 82-adrenergic receptor gene in response to short-term agonist exposure ( transcriptional activation / second messenger / epinephrine / transfection / down-regulation ) (0)
Table 3A, SAR Analysis for Selective κ –opioid receptor antagonists of the sulfonamide sub-scaffold 1 (2010) (0)
PL.05.01 The future of molecular pharmacology and drug discovery in psychiatry (2013) (0)
Separation, identification and characterization of two structural domains of the mammalian. beta. /sub 2/-adrenergic receptor (1986) (0)
[Figure, Summary of probe properties (solubility, absorbance/fluorescence, reactivity, toxicity, etc.)]. (2010) (0)
Isolation and characterization of the beta-adrenergic receptor of frog erythrocytes and development of potential affinity ligands. (1981) (0)
Targeting beta‐arrestins in the treatment of Parkinson's disease (796.6) (2014) (0)
Regions of the a1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function (182-adrenergic receptor/guanine nucleotide-binding protein/phospholipase C/constitutive activity) (2016) (0)
Table 4, Probe #2: SAR of selective GPR35 antagonists, including probe CID1542103 (2010) (0)
Procedures for testing receptor activity and useful constructions in such processes. (1998) (0)
Isolation And Biochemical Characterization Of The D1 And D2 Dopamine Receptors (1988) (0)
A convergent depression vulnerability pathway encoded by emergent spatiotemporal dynamics (2017) (0)
Effects of ethanol on muscarinic acetylcholine receptors in nerve cells (2002) (0)
Genetically Altered Mice as Models for Understanding Brain Disorders (2003) (0)
Involvement of Dopamine Transporters in Psychiatric Disorders (2000) (0)
An approach to the study of G-protein-coupled receptor kinases : An in vitro-purified membrane assay reveals differential receptor specificity and regulation by GI 8 y subunits ( phosphorylation assay / receptor kinase specificity ) (0)
Molecular neurobiology. The chimaeras speak again. (1993) (0)
Membrane-bound hormone receptor purification and characterization by HPLC (2020) (0)
Konstitutiv desensitierte g-protein-gekoppelte rezeptoren (2002) (0)
Deletion of Glycogen Synthase Kinase-3 β in D 2 Receptor-Positive Neurons Ameliorates Cognitive Impairment via N -Methyl-D-Aspartate Receptor-Dependent Synaptic Plasticity (2020) (0)
Table 5, SAR of GPR55 Antagonist Probe ML191 (#3): CID23612552 (2011) (0)
Faculty Opinions recommendation of Functional map of arrestin-1 at single amino acid resolution. (2014) (0)
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis (2019) (0)
Neuron-selective deletion of β-arrestin-2 uncovers unique mechanism of dopamine D2 receptor-biased ligands (2016) (0)
[Table, Primary Screen Protocol]. (2010) (0)
The Use of Phosphatidylethanol ( PEth ) as a Direct Alcohol Biomarker : An Annotated Bibliography (2014) (0)
The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse (2014) (0)
af-Agonist-and prostaglandin El-induced translocation of the , /-adrenergic receptor kinase : Evidence that the kinase may act on multiple adenylate cyclase-coupled receptors ( desensitization / receptor uncoupling / down-regulation ) (0)
Beta-arrestin and GPCR desensitization, internalization, and signaling (2001) (0)
Biochemical Characterization of the Cloned Human 5-HT1A Receptor Expressed in Mammalian Cells (1990) (0)
Figure 6, Lack of glutathione reactivity of ML194 (2011) (0)
The α1-Adrenergic Receptor as a Paradigm of Receptors Coupled to Guanine Nucleotide Binding Proteins (1990) (0)
Figure 4b, Reverse-Phase High Performance Liquid Chromatogram of ML194 (2011) (0)
Table 3, SAR of GPR55 Antagonist Probe ML193 (#1): CID1261822 (2011) (0)
Functional interaction between the dopamine transporter and the synaptic PDZ domain-containing protein PICK1 (2001) (0)
Table 7, Properties Computed from Structure CID3342390 (MLS0026993322) (2010) (0)
Figure 2, 35S-GTPγS binding assay – Secondary functional assays for KOR agonist probes and selected analogs (2010) (0)
Age-dependent decrease in retinal ganglion cells and mitophagy associated with loss of optineurin (2018) (0)
The role of protein kinase a (PKA) dependent phosphorylation of the secretin receptor in receptor internalization (2000) (0)
[Table, A tabular presentation summarizing known probe properties (computed properties, must match from PubChem)]. (2011) (0)
Establishment of Multi-stage Models of Drug Taking and Seeking in Mice (2020) (0)
Relevance of GPCR functional selectivity/biased signaling to drugs of abuse (468.1) (2014) (0)
Table 5, Probe and Analog Submissions to the MLMR (BioFocus DPI) (2010) (0)
Molecular characterization of the beta-adrenergic receptor of frog erythrocytes. (1982) (0)
Loss Of β-ARRESTIN2 In D2 Cells Alters Neuronal Excitability And Behavioral Responses To Drugs Of Abuse (2019) (0)
Table 3, Probe #1: SAR of selective GPR35 antagonists, including probe CID2286812 (2010) (0)
Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens (2023) (0)
the Ghrelin Receptor-Arrestin Signaling Bias at β G Protein and Signal Transduction : (2014) (0)
Correction: The Stem Cell-Expressed Receptor Lgr5 Possesses Canonical and Functionally Active Molecular Determinants Critical to β-arrestin-2 Recruitment (2014) (0)
Table 8, Calculated physical properties of Kappa opioid Agonist probe(s) (2010) (0)
Methods for the study of receptor activity and constructs which are useful in such methods (1998) (0)
Figure 5, Potency & Selectivity of GPR35 Antagonist Probe ML194 (2011) (0)
Photoaffinity labeling of beta-adrenergic receptors in mammalian tissues. (1984) (0)
A rapid and affordable screening platform for membrane protein trafficking (2015) (0)
Figure 1, Summary of the hit structures for the KOP antagonist project (2010) (0)
AKT / GSK 3 signaling cascade in dopamine actions (2006) (0)
Guanine nucleotide regulatory protein co-purifies with the D/sub 2/-dopamine receptor (1986) (0)
Table 9, Downstream assays by Assay Provider (2011) (0)
9 – Dopamine Receptors (2004) (0)
Genetic models in pharmacology: present status and future. (1999) (0)
Scheme 1, Synthetic route for probe molecule and supporting analogsa (2010) (0)
Structure/function and new members of the catecholamine receptor family (1990) (0)
343 Myofibroblasts Promote the Growth of Biliary Tree During Cholestatic Liver Injury By Suppressing Tryptophan Hydroxylase 2 (TPH2) Expression and Serotonin Secretion in Neighboring Cholangiocytes (2009) (0)
In Vivo Evidence for and Consequences of Functional Selectivity (2009) (0)
Table 6, Stability of ML194 in 1:1 PBS/ACN (2011) (0)
Purification and reconstitution of the human platelet. cap alpha. /sub 2/-adrenergic receptor (1986) (0)
Table 6, Probe Submission for GPR55 Antagonist Probes (2011) (0)
[Figure], Critical Path Flowchart for KOR Antagonist Project (2010) (0)
Figure 4a, 1H-NMR spectrum of ML194 (2011) (0)
G protein-coupled receptor kinase (GRK) specificity of endogenous type 1 vasoactive intestinal polvpeptide (VIP) receptor expressed on the surface of HEK 293 cells (2000) (0)
List of Contributors and Discussants (1981) (0)
Table 1, Listing of all Assays and AIDs for this project (2010) (0)
andchromosomal assignment ofageneencoding asecond D1dopamine receptor subtype: Differential expression pattern inratbraincompared (1991) (0)
Models for Regulation of Signal Transduction Processes (2005) (0)
Table 5A, Submission information on Probe 1: CID2286812 and analogs (2010) (0)
THE α1-ADRENERGIC RECEPTOR SUBTYPE COUPLES TO PHOSPHOLIPASE C (1991) (0)
Table 7, Properties ML194 (CID9581011) MLS-0300303 (2011) (0)
Table 7, Summary of in vitro ADME/T Properties of Kappa Opioid Agonist probe(s) (2010) (0)
Inhibition des gpcr induite par la phosphoinositide 3-kinase (2003) (0)
THE BETA-ADRENERGIC RECEPTOR OF FROG ERYTHROCYTE: PURIFICATION BY BIOSPECIFIC AFFINITY CHROMATOGRAPHY (1979) (0)
Table 8A, Comparative Downstream and Selectivity assays by Assay Provider for CID2286812 (2010) (0)
Table 2, Critical Reagents used for the uHTS experiments (2011) (0)
The molecular basis of adrenergic receptor function (1990) (0)
Table 1, Assays for GPR35 (2011) (0)
Targeting Beta-Arrestin Dependent Signaling in the Treatment of Parkinson’s Disease (2014) (0)
Affinity chromatography of the beta-adrenergic receptor and characterization of antibodies raised against purified receptor preparations. (1980) (0)
Addition to "Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity". (2021) (0)
Inhibition of fi-adrenergic receptor kinase prevents rapid homologous desensitization of f 82-adrenergic receptors ( A 431 celis / permeabilization / receptor phosphorylation / heparin ) (0)
A small region of the /3-adrenergic receptor is selectively involved in its rapid regulation (sequestration/phosphorylation/desensitization) (2016) (0)
Figure 3, Structure of Probe ML194 (2011) (0)
Table 5, Receptor Paneling of KOP agonist [ML140] CID3342390 through the PDSP (2010) (0)
β‐arrestin‐dependent Signaling of Dopamine D2 Receptor in the CNS: Opportunities for functionally selective therapeutic approaches. (2011) (0)
failuredysfunction in conscious dogs with heart Time course of sympathovagal imbalance and left (2015) (0)

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