Marc A. Laruelle
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Marc A. Laruelle's Degrees
- Masters Chemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
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(Suggest an Edit or Addition)Marc A. Laruelle's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands (2007) (1854)
- Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. (1996) (1271)
- Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. (2000) (1039)
- Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review (2000) (972)
- Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort. (1998) (805)
- Prefrontal Dopamine D1 Receptors and Working Memory in Schizophrenia (2002) (732)
- Increased dopamine transmission in schizophrenia: relationship to illness phases (1999) (711)
- Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum (2003) (568)
- Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography: I. Accuracy and Precision of D2 Receptor Parameter Measurements in Ventral Striatum (2001) (561)
- Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. (2010) (499)
- Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies (1999) (427)
- Alcohol Dependence Is Associated with Blunted Dopamine Transmission in the Ventral Striatum (2005) (425)
- Glutamate, Dopamine, and Schizophrenia (2003) (409)
- Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia (2000) (398)
- Imaging dopamine receptors in humans with [11C]-(+)-PHNO: Dissection of D3 signal and anatomy (2011) (372)
- Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease. (1993) (370)
- SPECT imaging of dopamine and serotonin transporters with [123I]β‐CIT: Pharmacological characterization of brain uptake in nonhuman primates (1993) (363)
- Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil. (1998) (358)
- Spect imaging of striatal dopamine release after amphetamine challenge in humans: Relationship between subjective effects and dopamine release (1995) (347)
- The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies (2000) (340)
- Neurobiology of dopamine in schizophrenia. (2007) (326)
- Low dopamine D(2) receptor binding potential in social phobia. (2000) (319)
- Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment. (2003) (317)
- Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine. (2007) (314)
- Imaging dopamine transmission in schizophrenia. A review and meta-analysis. (1998) (305)
- Graphical, Kinetic, and Equilibrium Analyses of in vivo [123I]β-CIT Binding to Dopamine Transporters in Healthy Human Subjects (1994) (296)
- Cocaine Dependence and D2 Receptor Availability in the Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior (2004) (285)
- Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans (1997) (275)
- Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. (2005) (274)
- Microdialysis and SPECT measurements of amphetamine‐induced dopamine release in nonhuman primates (1997) (272)
- Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652. (2005) (247)
- Age-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries. (2002) (246)
- Effects of statistical noise on graphic analysis of PET neuroreceptor studies. (2000) (239)
- Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. A postmortem study. (1993) (239)
- Measuring Drug Occupancy in the Absence of a Reference Region: The Lassen Plot Re-Visited (2010) (239)
- Validation and Reproducibility of Measurement of 5-HT1A Receptor Parameters with [carbonyl-11C]WAY-100635 in Humans: Comparison of Arterial and Reference Tissue Input Functions (2000) (231)
- Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography. (2003) (227)
- Age-Related Decline in Striatal Dopamine Transporter Binding with Iodine-123-β-CITSPECT (1995) (219)
- The role of serotonin in the pathophysiology and treatment of schizophrenia. (1997) (212)
- Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers. (2001) (202)
- COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET (2008) (202)
- The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans (2001) (195)
- Baseline and Amphetamine-Stimulated Dopamine Activity Are Related in Drug-Naïve Schizophrenic Subjects (2009) (190)
- Mechanisms of action of second generation antipsychotic drugs in schizophrenia: insights from brain imaging studies (2005) (181)
- Regional and subcellular localization in human brain of [3H]paroxetine binding, a marker of serotonin uptake sites (1988) (180)
- Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain (2016) (177)
- How does pindolol improve antidepressant action? (2001) (175)
- The Synaptic Hypothesis of Schizophrenia (2003) (167)
- Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]‐(+)‐PHNO is a D3 receptor preferring agonist in vivo (2006) (165)
- Amphetamine‐stimulated dopamine release competes in vivo for [123I]IBZM binding to the D2 receptor in nonhuman primates (1992) (164)
- Cognitive and brain function in schizotypal personality disorder (2002) (162)
- Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. (2004) (159)
- SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil: kinetic and equilibrium paradigms. (1994) (158)
- D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene (1998) (157)
- Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT. (1998) (155)
- Measurement of Striatal and Extrastriatal Dopamine D1 Receptor Binding Potential With [11C]NNC 112 in Humans: Validation and Reproducibility (2000) (154)
- Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation. (2005) (153)
- Altered prefrontal dopaminergic function in chronic recreational ketamine users. (2005) (152)
- Schizophrenia: from dopaminergic to glutamatergic interventions. (2014) (151)
- In vivo vulnerability to competition by endogenous dopamine: Comparison of the D2 receptor agonist radiotracer (–)‐N‐[11C]propyl‐norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]‐raclopride (2004) (151)
- In vivo quantification of brain serotonin transporters in humans using [11C]McN 5652. (2000) (150)
- Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT (2000) (149)
- Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11C]PHNO, and a Selective D3 Receptor Antagonist (2010) (149)
- Within-Subject Comparison of [11C]-( + )-PHNO and [11C]raclopride Sensitivity to Acute Amphetamine Challenge in Healthy Humans (2012) (148)
- Single photon emission computed tomography imaging of monoamine reuptake sites in primate brain with [123I]CIT. (1991) (141)
- Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM (2002) (133)
- SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT. (1996) (130)
- Positron emission tomography imaging of amphetamine‐induced dopamine release in the human cortex: A comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride (2009) (129)
- Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression (2001) (128)
- In vivo quantification of regional dopamine‐D3 receptor binding potential of (+)‐PHNO: Studies in non‐human primates and transgenic mice (2009) (128)
- Differential Occupancy of Somatodendritic and Postsynaptic 5HT1A Receptors by Pindolol: A Dose-Occupancy Study with [11C]WAY 100635 and Positron Emission Tomography in Humans (2001) (126)
- Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine (2009) (126)
- Dose–Occupancy Study of Striatal and Extrastriatal Dopamine D2 Receptors by Aripiprazole in Schizophrenia with PET and [18F]Fallypride (2008) (125)
- Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype. (2004) (124)
- Increased prefrontal cortical D1 receptors in drug naïve patients with schizophrenia: a PET study with [11C]NNC112 (2012) (122)
- Prefrontal Cortical Projections to the Midbrain in Primates: Evidence for a Sparse Connection (2006) (122)
- Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide (2004) (121)
- Striatal and extrastriatal dopamine release measured with PET and [18F] fallypride (2010) (116)
- The role of in vivo molecular imaging with PET and SPECT in the elucidation of psychiatric drug action and new drug development (2002) (116)
- Positron emission tomography: imaging and quantification of neurotransporter availability. (2002) (114)
- Age-related decline in central serotonin transporter availability with [123I]β-CIT SPECT (2000) (113)
- PET Studies of Binding Competition between Endogenous Dopamine and the D1 Radiotracer [11C]NNC 756 (1998) (106)
- SPECT Quantification of [123I]Iomazenil Binding to Benzodiazepine Receptors in Nonhuman Primates: II. Equilibrium Analysis of Constant Infusion Experiments and Correlation with in vitro Parameters (1994) (105)
- NMDA antagonist effects on striatal dopamine release: Positron emission tomography studies in humans (2002) (99)
- In Vivo DA D1 Receptor Selectivity of NNC 112 and SCH 23390 (2007) (98)
- Compartmental modeling of iodine-123-iodobenzofuran binding to dopamine D2 receptors in healthy subjects. (1994) (96)
- (−)-N-[11C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D2 receptors (2000) (95)
- Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain (2010) (95)
- Dopamine Depletion and In Vivo Binding of PET D1 Receptor Radioligands: Implications for Imaging Studies in Schizophrenia (2003) (92)
- Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [11C]McN 5652 (2003) (91)
- Striatal dopamine D2 receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings (2008) (90)
- SPECT Quantification of [123I]Iomazenil Binding to Benzodiazepine Receptors in Nonhuman Primates: I. Kinetic Modeling of Single Bolus Experiments (1994) (89)
- Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies (2000) (88)
- Stability of [123I]IBZM SPECT measurement of amphetamine‐induced striatal dopamine release in humans (1999) (87)
- The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction. (2013) (87)
- Affinity and selectivity of [11C]‐(+)‐PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo (2012) (86)
- Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods. (2006) (85)
- Dopamine transporters, D2 receptors, and dopamine release in generalized social anxiety disorder (2009) (84)
- Increased Serotonin 2A Receptor Availability in the Orbitofrontal Cortex of Physically Aggressive Personality Disordered Patients (2010) (83)
- Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD (2014) (81)
- Impact of D2 Receptor Internalization on Binding Affinity of Neuroimaging Radiotracers (2010) (80)
- Kinetic Modeling of 11C-SB207145 Binding to 5-HT4 Receptors in the Human Brain In Vivo (2009) (79)
- Effects of reduced endogenous 5‐HT on the in vivo binding of the serotonin transporter radioligand 11C‐DASB in healthy humans (2005) (79)
- Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study (2012) (78)
- SPECT imaging of the benzodiazepine receptor: feasibility of in vivo potency measurements from stepwise displacement curves. (1991) (77)
- Occupancy of brain serotonin transporters during treatment with paroxetine in patients with social phobia: a positron emission tomography study with [11C]McN 5652 (2002) (77)
- Reproducibility of iodine-123-beta-CIT SPECT brain measurement of dopamine transporters. (1996) (74)
- Effect of amphetamine on [18F]fallypride in vivo binding to D2 receptors in striatal and extrastriatal regions of the primate brain: Single bolus and bolus plus constant infusion studies (2004) (71)
- D2 Receptor Occupancy of Olanzapine Pamoate Depot Using Positron Emission Tomography: An Open-label Study in Patients with Schizophrenia (2008) (70)
- In vivo affinity of [18F]fallypride for striatal and extrastriatal dopamine D2 receptors in nonhuman primates (2004) (69)
- 11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons. (2005) (68)
- Striatal and Extrastriatal Dopamine D2/D3 Receptors in Schizophrenia Evaluated With [18F]fallypride Positron Emission Tomography (2010) (67)
- Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naı̈ve healthy volunteers: results from a large cohort (2003) (67)
- Evaluation of 11C-GSK189254 as a Novel Radioligand for the H3 Receptor in Humans Using PET (2010) (66)
- Derivation of [(11)C]WAY-100635 binding parameters with reference tissue models: effect of violations of model assumptions. (2000) (65)
- Prediction of panic response to a respiratory stimulant by reduced orbitofrontal cerebral blood flow in panic disorder. (2005) (64)
- Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635 (2006) (63)
- Reproducibility of SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil. (1995) (63)
- Age-related decline in striatal dopamine transporter binding with iodine-123-beta-CITSPECT. (1995) (63)
- [11C]NNC 112 Selectivity for Dopamine D1 and Serotonin 5-HT2A Receptors: A PET Study in Healthy Human Subjects (2007) (60)
- Sustained Recreational Use of Ecstasy Is Associated with Altered Pre and Postsynaptic Markers of Serotonin Transmission in Neocortical Areas: A PET Study with [11C]DASB and [11C]MDL 100907 (2012) (59)
- Methyl 3β‐(4‐[125I]Iodophenyl)Tropane‐2β‐Carboxylate In Vitro Binding to Dopamine and Serotonin Transporters Under “Physiological” Conditions (1994) (59)
- Measurement of the Proportion of D2 Receptors Configured in State of High Affinity for Agonists in Vivo: A Positron Emission Tomography Study Using [11C]N-Propyl-norapomorphine and [11C]Raclopride in Baboons (2005) (58)
- Pharmacological and Regional Characterization of [3H]LY278584 Binding Sites in Human Brain (1993) (57)
- No Evidence of Altered In Vivo Benzodiazepine Receptor Binding in Schizophrenia (1999) (57)
- Serotonin Transporter Availability in Patients with Schizophrenia: A Positron Emission Tomography Imaging Study with [11C]DASB (2005) (57)
- Prediction of Repeat-Dose Occupancy from Single-Dose Data: Characterisation of the Relationship between Plasma Pharmacokinetics and Brain Target Occupancy (2011) (56)
- Age-related decline in central serotonin transporter availability with [(123)I]beta-CIT SPECT. (2000) (56)
- D1 and D2 receptor modulation in rat striatum and nucleus accumbens after subchronic and chronic haloperidol treatment (1992) (56)
- Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents. (2005) (55)
- Combining PET Biodistribution and Equilibrium Dialysis Assays to Assess the Free Brain Concentration and BBB Transport of CNS Drugs (2012) (54)
- Interactions between D1 and D2 dopamine receptor family agonists and antagonists: the effects of chronic exposure on behavior and receptor binding in rats and their clinical implications (2005) (53)
- Neuroreceptor imaging in psychiatric disorders (2002) (52)
- Striatal dopamine transporter availability with [123I]β-CIT SPECT is unrelated to gender or menstrual cycle (2005) (50)
- Pindolol augmentation of antidepressant treatment: recent contributions from brain imaging studies (2000) (49)
- Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implications (2003) (49)
- Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor (2012) (48)
- Dopamine Transmission in the Schizophrenic Brain (2007) (48)
- Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1 (2011) (46)
- Characterization in Humans of 18F-MNI-444, a PET Radiotracer for Brain Adenosine 2A Receptors (2015) (45)
- Modulation of Amphetamine-Induced Dopamine Release by Group II Metabotropic Glutamate Receptor Agonist LY354740 in Non-Human Primates Studied with Positron Emission Tomography (2006) (44)
- A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone. (2005) (44)
- Pharmacokinetics of the SPECT benzodiazepine receptor radioligand [123I]iomazenil in human and non-human primates. (1992) (44)
- Positron emission tomography imaging of dopamine D2/3 receptors in the human cortex with [11C]FLB 457: Reproducibility studies (2011) (44)
- Biodistribution and radiation dosimetry of the dopamine D2 ligand 11C-raclopride determined from human whole-body PET. (2006) (43)
- Donepezil Impairs Memory in Healthy Older Subjects: Behavioural, EEG and Simultaneous EEG/fMRI Biomarkers (2011) (43)
- 11C-GSK189254: A Selective Radioligand for In Vivo Central Nervous System Imaging of Histamine H3 Receptors by PET (2009) (43)
- Binding of serotonergic ligands to brain membranes of alcohol-preferring AA and alcohol-avoiding ANA rats. (1992) (43)
- Evaluation of dopamine D2/3specific binding in the cerebellum for the positron emission tomography radiotracer [11C]FLB 457: Implications for measuring cortical dopamine release (2011) (41)
- An improved one-pot procedure for the preparation of [11C-carbonyl]-WAY100635. (1999) (40)
- A new positron emission tomography imaging agent for the serotonin transporter: synthesis, pharmacological characterization, and kinetic analysis of [11C]2-[2-(dimethylaminomethyl)phenylthio]-5-fluoromethylphenylamine ([11C]AFM). (2004) (40)
- (-)-N-[(11)C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D(2) receptors. (2000) (39)
- Measuring Dopamine Synaptic Transmission with Molecular Imaging and Pharmacological Challenges: The State of the Art (2012) (39)
- In vivo quantification of dopamine D2 receptor parameters in nonhuman primates with [123I]iodobenzofuran and single photon emission computerized tomography. (1994) (37)
- Mathematical modelling of [11C]-(+)-PHNO human competition studies (2013) (37)
- Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights. (2001) (36)
- Within-subject comparison of striatal D2 receptor occupancy measurements using [123I]IBZM SPECT and [11C]Raclopride PET (2008) (36)
- Preclinical evaluation of [123I]R93274 as a SPECT radiotracer for imaging 5-HT2A receptors. (1997) (36)
- Single photon emission tomography measurement of benzodiazepine receptor number and affinity in primate brain: a constant infusion paradigm with [123I]iomazenil. (1993) (35)
- Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: Quantitative analysis, test–retest reproducibility, and vulnerability to endogenous 5-HT tone (2012) (34)
- The 5-HT2A receptor and serotonin transporter in Asperger's Disorder: A PET study with [11C]MDL 100907 and [11C]DASB (2011) (33)
- Functional neuroimaging and electrophysiology biomarkers for clinical trials for cognition in schizophrenia. (2005) (33)
- Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys (2014) (32)
- Amphetamine‐induced dopamine release: Duration of action as assessed with the D2/3 receptor agonist radiotracer (––)‐N‐[11C]propyl‐norapomorphine ([11C]NPA) in an anesthetized nonhuman primate (2007) (31)
- Schizophrenia is associated with increased synaptic dopamine in associative rather than limbic regions of the striatum: Implications for mechanisms of action of antipsychotic drugs (2006) (31)
- Imaging Changes in Synaptic Acetylcholine Availability in Living Human Subjects (2013) (30)
- Identification and evaluation of [11C]GSK931145 as a novel ligand for imaging the type 1 glycine transporter with positron emission tomography (2010) (30)
- Positron Emission Tomography Imaging of the Serotonin Transporter and 5-HT1A Receptor in Alcohol Dependence (2009) (30)
- Unexpectedly high affinity of a novel histamine H3 receptor antagonist, GSK239512, in vivo in human brain, determined using PET (2014) (29)
- Euphorigenic doses of cocaine reduce [123I]β-CIT SPECT measures of dopamine transporter availability in human cocaine addicts (1995) (29)
- Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates. (2004) (29)
- Imaging the D3 receptor in humans in vivo using [11C](+)-PHNO positron emission tomography (PET). (2010) (29)
- Relationship Between Glycine Transporter 1 Inhibition as Measured with Positron Emission Tomography and Changes in Cognitive Performances in Nonhuman Primates (2014) (27)
- Characterization of in vivo pharmacological properties and sensitivity to endogenous serotonin of [11C] P943: A positron emission tomography study in Papio anubis (2011) (27)
- In vivo evaluation of [11C]N-(2-chloro-5-thiomethylphenyl)-N'-(3-methoxy-phenyl)-N'-methylguanidine ([11C]GMOM) as a potential PET radiotracer for the PCP/NMDA receptor. (2004) (26)
- Dopamine receptors and transporters : function, imaging, and clinical implication (2003) (26)
- Imaging neurochemical endophenotypes: promises and pitfalls. (2001) (25)
- Comparison of three high affinity SPECT radiotracers for the dopamine D2 receptor. (1994) (25)
- Imaging Cortical Dopamine D1 Receptors Using [11C]NNC112 and Ketanserin Blockade of the 5-HT2A Receptors (2010) (24)
- Simplified multidose preparation of iodine-123-beta-CIT: a marker for dopamine transporters. (1995) (24)
- In vitro assessment of the agonist properties of the novel 5-HT1A receptor ligand, CUMI-101 (MMP), in rat brain tissue. (2011) (24)
- Serotonin 5-HT3 receptors in schizophrenia: a postmortem study of the amygdala (1993) (24)
- Regional distribution of serotonergic pre‐ and postsynaptic markers in human brain (1989) (23)
- Positron emission tomography study of pindolol occupancy of 5-HT(1A) receptors in humans: preliminary analyses. (2000) (23)
- A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA). (2004) (22)
- Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies. (2009) (21)
- Comparison of [11C]PBR28 and [18F]FEPPA as CNS peripheral benzodiazepine receptor PET ligands in the pig (2008) (21)
- Synthesis and pharmacological characterization of a new PET ligand for the serotonin transporter: [11C]5-bromo-2-[2-(dimethylaminomethylphenylsulfanyl)]phenylamine ([11C]DAPA). (2002) (20)
- Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-CIT) to monoamine transporters. (1993) (20)
- The role of model-based methods in the development of single scan techniques. (2000) (20)
- An evaluation of the brain distribution of [11C]GSK1034702, a muscarinic-1 (M1) positive allosteric modulator in the living human brain using positron emission tomography (2014) (20)
- Neuroreceptor imaging in psychiatry: theory and applications. (2005) (20)
- SPECT imaging of dopamine and serotonin transporters in nonhuman primate brain. (1994) (19)
- Fluorinated analogues of ADAM as new PET radioligands for the serotonin transporter: Synthesis and pharmacological evaluation (2001) (19)
- Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease (2015) (19)
- Positron-labeled dopamine agonists for probing the high affinity states of dopamine subtype 2 receptors. (2005) (19)
- Modelling: when and why? (1999) (18)
- PET imaging of dopamine-D2 receptor internalization in schizophrenia (2017) (18)
- Synthesis and in vivo evaluation of [11C]zolpidem, an imidazopyridine with agonist properties at central benzodiazepine receptors. (2003) (17)
- The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics. (2004) (17)
- PET Studies of Binding Competition Between Endogenous Dopamine and the D 1 (1999) (17)
- Characterising the plasma-target occupancy relationship of the neurokinin antagonist GSK1144814 with PET (2014) (16)
- Epibatidine analogues as selective ligands for the αxβ2-containing subtypes of nicotinic acetylcholine receptors (2005) (16)
- Monoamine Transporter Occupancy of a Novel Triple Reuptake Inhibitor in Baboons and Humans Using Positron Emission Tomography (2013) (16)
- The Second Revision of the Dopamine Theory of Schizophrenia: Implications for Treatment and Drug Development (2013) (16)
- Methyl 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylate in vitro binding to dopamine and serotonin transporters under "physiological" conditions. (1994) (16)
- Biodistribution and Radiation Dosimetry of the Glycine Transporter-1 Ligand 11C-GSK931145 Determined from Primate and Human Whole-Body PET (2011) (15)
- Characterization of [125I]SCH 23982 binding in human brain: Comparison with [3H]SCH 23390 (1991) (15)
- Pharmacological and Genetic Characterization of Two Selective Serotonin Transporter Ligands: 2-[2-(Dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-Amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB) (2004) (14)
- Plasmatic vasopressin neurophysin in depression: Basic levels and relations with HPA axis (1990) (13)
- Impact of scatter correction on D2 receptor occupancy measurements using 123I-IBZM SPECT: Comparison to 11C-Raclopride PET (2010) (13)
- Pharmacokinetics and brain distribution in non human primate of R(-)[123I]DOI, A 5HT(2A/2C) serotonin agonist. (2002) (13)
- Synthesis of potent and selective serotonin 5-HT1B receptor ligands. (2005) (13)
- Evaluation of the novel 5-HT6 receptor radioligand, [11C]GSK-215083 in human (2008) (13)
- Coupling efficiency of brain β-adrenergic receptors to Gs protein in suicide, alcoholism and control subjects (1999) (12)
- In vivo evaluation of [11C]-3-[2-[(3-methoxyphenylamino)carbonyl]ethenyl]-4,6-dichloroindole-2-carboxylic acid ([11C]3MPICA) as a PET radiotracer for the glycine site of the NMDA ion channel. (2002) (12)
- Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone (2011) (10)
- Synthesis of [123I]IBZM: a reliable procedure for routine clinical studies. (1999) (10)
- [11C]GSK931145: A new pet ligand for glycine transporter 1 (2008) (10)
- Pharmacokinetics of the three radioiodinated dopamine D2 receptor ligands [123I]IBF, [123I]epidepride and [123I]2'-ISP in nonhuman primates. (1994) (9)
- Synthesis and characterization of two pet radioligands for the metabotropic glutamate 1 (mGlu1) receptor (2012) (9)
- Kinetic Derivation of Serotonin 5HT-1A Receptor Binding Potential with [11C]Carbonyl-Way 100635 and Competition Studies with Endogenous Serotonin (1998) (9)
- Cocaine Dependence and D2 Receptor Availability in Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior (2004) (9)
- Blood brain barrier permeability of [11C]loperamide in humans under normal and impaired P-glycoprotein function (2008) (9)
- Partial Volume Effect Correction (2001) (8)
- Characterization of the dopamine transporter in nonhuman primate brain: homogenate binding, whole body imaging, and ex vivo autoradiography using [125I] and [123I]IPCIT. (1995) (8)
- Contribution of D3 receptors to the in vivo binding of [11C]PHNO in the primate brain (2008) (7)
- The role of P-glycoprotein on blood brain barrier permeability of [11C]Loperamide in humans (2008) (7)
- Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. (2001) (7)
- SEROTONIN AND SCHIZOPHRENIA : A REVIEW (1996) (6)
- Biodistribution and Radiation Dosimetry of the Serotonin 5-HT6 Ligand [11C]GSK215083 Determined from Human Whole-Body PET (2012) (6)
- First evaluation in humans of [11C]GSK215083 as a probe to image the 5-HT6 receptors (2008) (6)
- Ligand Tracer Kinetics: Theory and Application (2004) (6)
- SPECT imaging of synaptic dopamine release in drug free schizophrenic patients: An experimental validation of the dopamine hypothesis of schizophrenia (1996) (6)
- Synthesis and evaluation of 18F-UCB-H, a novel PET imaging tracer for the synaptic vesicle protein 2A (2014) (6)
- D3 receptor assessment in vivo: PET with [11C]PHNO and SB-277011 (2008) (6)
- PET imaging of dopamine-D2 receptor internalization in schizophrenia. (2017) (6)
- Active and inactive enantiomers of 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: comparison using homogenate binding and single photon emission computed tomographic imaging. (1994) (6)
- Evaluation of [3H]LY341495 for labeling group II metabotropic glutamate receptors in vivo. (2003) (5)
- Comparison of [123I]ß-CIT and [123I]IPCIT as single-photon emission tomography radiotracers for the dopamine transporter in nonhuman primates (2005) (5)
- Development and evaluation of [11C]GSK931145, a new PET ligand for imaging type 1 glycine transporters (GlyT1) in the living human brain (2008) (5)
- Dopamine and persecutory delusions (2008) (5)
- Pharmacological selectivity of the in vivo binding of [11C]NNC 112 and [11C]SCH 23390 in the cortex: A PET study in baboons (2006) (5)
- Epibatidine analogues as selective ligands for the alpha(x)beta2-containing subtypes of nicotinic acetylcholine receptors. (2005) (5)
- Rapid Communication Age-related decline in central serotonin transporter availability with ( 123 I)b-CIT SPECT < (2000) (5)
- [11C]UCB-J: A novel PET tracer for imaging the synaptic vesicle glycoprotein 2A (SV2A) (2014) (5)
- Synthesis and characterization of 4,6-dichloroindole-based radioligands for imaging the glycine site of the NMDA ion channel (2002) (4)
- Characterization in Humans of 18 F-MNI-444 , a PET Radiotracer for Brain Adenosine 2 A Receptors (2015) (4)
- Impact of dopamine D2 receptor internalization on binding parameters of D2 PET radiotracers (2008) (4)
- Preparation and evaluation of [F‐18]‐labeled 5‐HT1A Agonist: 1‐[2‐(4‐[F‐18]Fluorobenzamido)‐1‐Ethyl]‐4‐(1,2,3,4‐Tetrahydronaphth‐1‐YL)‐Piperidine (FBP) (2001) (4)
- Agonist-mediated internalization of dopamine D2 receptors does not appear to mediate the decrease in benzamides binding potential observed after dopamine surge (2006) (4)
- A multicentre double blind comparative study between paroxetine and maprotiline in major depression (1991) (4)
- Striatal and extrastriatal dopamine D 2 /D 3 receptors in schizophrenia evaluated with [ 18 F]fallypride PET (2010) (4)
- SPECTImagingof StriatalDopamineRelease after Amphetamine Challenge (1995) (4)
- Imaging Receptor Occupancy by Endogenous Transmitters in Humans (1998) (4)
- Dopaminergic Receptor Function Defined by Studying Genetically Altered Mice (2003) (4)
- 5:00 PM NEGATIVE MODULATION OF THE SYNAPTIC VESICLE PROTEIN (SV2A): A NEW PHARMACOLOGICAL TARGET FOR COGNITIVE DEFICIT ASSOCIATED WITH SCHIZOPHRENIA (2014) (3)
- Dopaminergic Systems in Parkinson’s Disease (2003) (3)
- A double-blind study of paroxetine and maprotiline in major depression (1994) (3)
- Effect of antipsychotic treatment on cortical D1 receptors (2010) (3)
- Comparison of Kinetic Modeling Methods for the In Vivo Quantification of 5-HT1A Receptors Using WAY 100635 (2001) (3)
- Molecular Imaging in Psychiatric Disorders (2003) (3)
- Kinetic analysis of [11C]GSK189254, a novel radioligand for the H3 receptor in humans using positron emission tomography (PET) (2008) (3)
- Ibotenic acid or ablation lesions of the frontal cortex do not alter the density or the affinity of D1 and D2 receptors in the corpus striatum or nucleus accumbens (1991) (3)
- A pseudo-reference region method applied to measurement of GlyT1 occupancy in human brain using [11C]GSK931145 and PET (2010) (3)
- [123I]IPCIT and [123I]beta-CIT as SPECT tracers for the dopamine transporter: a comparative analysis in nonhuman primates. (2000) (3)
- 208. Increased striatal dopamine release in drug free schizophrenic subjects (1996) (3)
- Evaluation of [11C]GSK189254 as a novel radioligand for the H3 receptor in human using positron emission tomography (PET) (2008) (3)
- In Vivo Imaging of Dopamine Receptors (2010) (3)
- ABNORMALITIES OF SEROTONERGIC NEURAL TRANSMISSION IN PREFRONTAL CORTEX IN SCHIZOPHRENIA (1992) (3)
- Neuroimaging Research and Neurocircuitry Models of Obsessive-Compulsive Disorder: Proceedings of the Third IOCDC (1999) (3)
- Within-subject comparison of the sensitivity of [11C]-(+)-PHNO and [11C]raclopride to amphetamine induced changes in endogenous dopamine in healthy human volunteers (2010) (3)
- Spect imaging of the benzodiazepine receptor in schizophrenics and healthy subjects (1995) (3)
- Imaging acetylcholine effects on [123I]5IA-85380 binding to beta2-nicotinic acetylcholine receptors: Physostigmine studies in human subjects (2012) (3)
- Enhanced amphetamine-induced striatal [11C]raclopride displacement by the group II metabotropic glutamate receptor agonist LY354740 in baboons (2002) (3)
- Physiology, Pharmacology, and Pathophysiology of the D1-like Family of Dopamine Receptors in the Central Nervous System (2003) (3)
- Images in neuroscience. SPECT imaging of synaptic dopamine. (1996) (3)
- The Effect of Activity from Outside the Field of View on Accurate Quantification of 3D PET Images (2002) (2)
- Imaging cortical dopamine D 1 receptors using ( 11 C)NNC112 and ketanserin blockade of (2010) (2)
- Measurement of Partial Volume Effect in the Ventral Striatum Using [11C]Raclopride (2002) (2)
- The Dopamine D3 Receptor in the Pathophysiology and Treatment of Neuropsychiatric Disorders (2003) (2)
- Evaluation of the in vivo ED50 for the PET Radioligand, [11C]GSK-215083, in Papio anubis (2010) (2)
- Protein precipitation: an expedient procedure for the routine analysis of the plasma metabolites of [123I]IBZM. (1999) (2)
- Letter to the editor re: Logan et al., 1997 (1998) (2)
- 507 In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patients (1997) (2)
- 5-HTTLPR Polymorphisms (SLC6A4 & rs25531) do not affect 5-HT transporter expression in the living human brain (2008) (2)
- D-amphetamine displacement of [123I]IBF equilibrium binding in primates: A new paradigm to investigate D-amphetamine induced dopamine release. (1993) (2)
- Synthesis of Potent and Selective Dopamine D4 Antagonists as Candidate Radioligands. (2001) (1)
- Brain Imaging in Depression and Anxiety (2003) (1)
- Preparation and evaluation of [11C]‐labeled 5HT1A agonist: (R)‐10‐Methyl‐11‐hydroxyaporphine (2001) (1)
- Amphetamine-induced striatal dopamine release in major depressive disorder (2010) (1)
- Chapter 24 Antipsychotic-Induced Changes in Striatal D2 Receptors in Schizophrenia: In Vivo Evidence from Dopamine Depletion Studies (2012) (1)
- [18F]Fallypride PET assessment of D2/D3 receptor binding in schizophrenia (2008) (1)
- Estimation of occupancy in the absence of baseline data and reference regions (2007) (1)
- 494 Spect measurement of human striatal synaptic dopamine concentration with [123I]IBZM (1997) (1)
- Impact of presynaptic dopamine activity on D1 radiotracer binding in vivo in rodent brain (2006) (1)
- Reproducibility of Radioligand Measurements of Pharmacologically Induced Striatal Dopamine Release in Humans (2001) (1)
- Spect imaging of the benzodiazepine receptor in humans using [123I]iomazenil (1993) (1)
- Model-based sequential human PET study design for Optimal PK/RO assessment (2007) (1)
- Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transporters (NET and SERT): Implications for treatment of depression and ADHD (2009) (1)
- INCREASED 5-HT 2A RECEPTOR AVAILABILITY IN THE ORBITOFRONTAL CORTEX OF PHYSICALLY AGGRESSIVE PERSONALITY DISORDERED PATIENTS (2011) (1)
- Negative modulation of the synaptic vesicle protein (SV2A): a new pharmacological target for cognitive deficit associated with schizophrenia (2014) (1)
- Radioligand for the H 3 Receptor in Humans Using PET (2010) (1)
- Different profile of the neuroleptic induced upregulation of the dopaminergic d2 receptors in nigrostriatal and mesolimbic systems (1990) (1)
- Wavelet denoising of PET images: Effect on the accuracy of the AIR algorithm (2000) (1)
- SPECT Imaging of Resting Dopamine Synaptic Release in the Striatum of Untreated Schizophrenic Patients (1998) (1)
- PET imaging of D1 receptors in striatal subdivisions in schizophrenia (2009) (1)
- PET imaging of dopamine D3 receptors in humans with [11C]-(+)-PHNO: dissection of PHNO signal using two highly selective D3 antagonists (2010) (1)
- Differential occupancy of 5HT-1A autoreceptors and post-synaptic receptors by pindolol in humans measured with PET and [ 11C-carbonyl] WAY 100635 (2000) (1)
- Characterising the relationship between plasma pharmacokinetics and occupancy following single dose allows prediction of repeat dose occupancy (2009) (1)
- Evaluation of the putative dopamine D3 PET tracer [11C]WC-10 in non-human primates (2008) (1)
- Epibatidine Analogues as Selective Ligands for the αxβ2-Containing Subtypes of Nicotinic Acetylcholine Receptors. (2005) (1)
- Awake nonhuman primate brain PET imaging without head restraint (2010) (1)
- Neuroimaging Findings in Schizophrenia: From Mental to Neuronal Fragmentation (2003) (1)
- Imaging drug action in schizophrenia: research update (2003) (1)
- Vulnerability of [18F]fallypride in vivo binding in striatal and extrastriatal regions following a D-amphetamine challenge in baboons: Single bolus and bolus plus constant infusion studies (2003) (1)
- In vivo assessment of [18F]MNI-444 in human brain: A novel A2a receptor PET tracer (2014) (1)
- 20. PET imaging of serotonin responsivity: relationship to mood and impulsivity (2000) (1)
- The 5HT-2A receptor and 5HT transporter in Asperger's disorder: A PET study with [11C]MDL and [11C]DASB (2010) (0)
- Cortical D1 across COMT genotypes (2006) (0)
- S40 PREFRONTAL DOPAMINE TRANSMISSION IN SCHIZOPHRENIA: IS D1 RECEPTOR A RELEVANT BIOMARKER? (2005) (0)
- PET measurement of nicotine evoked dopamine release (2010) (0)
- PET imaging of neurotransmitter function (2001) (0)
- Reply to the editor (2001) (0)
- Quantitative Analysis of ( (cid:1) )- N - 11 C-Propyl-Norapomorphine In Vivo Binding in Nonhuman Primates (2004) (0)
- S49 IMAGING DOPAMINE ACTIVITY IN FUNCTIONAL SUBDIVISION OF THE STRIATUM WITH PET: CLINICAL IMPLICATIONS (2005) (0)
- 250. The dopamine hypothesis of schizophrenia—alive, well and moving ahead (1998) (0)
- S.06.02 Imaging dopamine synaptic activity with PET (2003) (0)
- Further validation of [11C]FLB 457 as a tool to measure prefrontal cortical DA release (2010) (0)
- Pharmacological evaluation of the novel D2/3 agonist radiotracer [11C]-(+)-PHNO in anesthetized non-human primates: A potential D3 receptor preferring agonist? (2006) (0)
- Affinity of dopamine for the D3 and D2 high receptors in the human brain in vivo (2011) (0)
- Tritium labelled paroxetine binding in postmortem brains of schizophrenics suicides cocaine addicts and controls (1990) (0)
- D2/D3 receptor binding in striatal and extrastriatal regions in schizophrenia measured with [18F]fallypride PET (2008) (0)
- Human dosimetry for the 5-HT6 PET ligand [11C]GSK215083 (2009) (0)
- RE: Logan et al., 1997. (1998) (0)
- Correlation between PET and microdialysis measurements of amphetamine induced DA release in striatal and extrastriatal brain regions in baboons (2007) (0)
- Endogenous sensitization in the pathophysiology of schizophrenia: Evidence from imaging studies (2002) (0)
- Brain PET Oral 4: in vivo Pharmacology I—Dopamine and Norepinephrine (2009) (0)
- A combined diffusion tensor imaging (DTI) and [11C]-(+)-PHNO positron emission tomography (PET) study to quantify dopamine D3/D2 receptors in pallidum (2010) (0)
- Reproducibility of SPECT Measurement of Striatal Amphetamine-Induced Dopamine Release in Healthy Subjects (1998) (0)
- Using in vitro measurements of plasma and tissue free fractions to interpret radioligand uptake (2007) (0)
- Dopaminergic Hyperactivity in Striatum in Schizophrenia: A Failure of Cortical Glutamatergic Control? (2002) (0)
- Amphetamine-induced dopamine release: Duration of action as assessed by the dopamine-2-receptor (D2) agonist [11C]NPA in baboons (2006) (0)
- Brain PET Oral 5: in vivo Pharmacology II—Serotonin (2009) (0)
- Measurement of neurotransmitters with positron emission tomography (2003) (0)
- [11C]raclopride PET measurement of mesolimbic and nigrostriatal ketamine-induced dopamine release in healthy humans (2000) (0)
- IMAGING STUDIES BRIDGING THE DOPAMINE AND GLUTAMATE HYPOTHESES OF SCHIZOPHRENIA (2008) (0)
- Combined spect and MRS study of subcortical dopamine dysregulation in schizophrenia (2003) (0)
- GLUTAMATE-DOPAMINE INTERACTIONS IN SCHIZOPHRENIA: INSIGHT FROM MOLECULAR IMAGING STUDIES (2012) (0)
- [11C](+)RX-821024: A novel tracer for imaging α2-adrenoceptors (2008) (0)
- Psychiatry — Relevance with Respect to Drug Development, Examples (2012) (0)
- In Vivo Effects of Psychostimulants on Brain Dopamine Systems (2003) (0)
- Imaging pure dopamine D1 receptors with [11C]NNC112 PET and ketanserin challenge (2009) (0)
- Striatal dopamine D2 receptor occupancy measurements using [123I]IBZM SPECT and [11C]Raclopride PET: A within-subject comparison study (2008) (0)
- Schizophrenia and Bipolar Disorder as Putative Dopamine-Linked Illnesses (2003) (0)
- Chapter 27 Antipsychotic-Induced Changes in Striatal D2 Receptors in Schizophrenia: In Vivo Evidence from Dopamine Depletion Studies (2013) (0)
- In vivo pharmacological evaluation of the 5HT-1B radioligand [11C]P943 in nonhuman primates using PET (2008) (0)
- Imaging Dopamine in Amphetamine-Induced Psychosis (2001) (0)
- Amphetamine challenge with [18F]fallypride: Striatal and extrastriatal measurements in healthy human volunteers (2008) (0)
- The 5-HT2A receptor and serotonin transporter in ecstasy users evaluated with [11C]MDL 100907 and [11C]DASB (2011) (0)
- PET imaging of the serotonin transporter and 5HT1A receptor in alcohol dependence (2009) (0)
- Polymorphic variations in the 5-HTT promoter region and 5 HTT binding in the human brain: A positron emission tomography study with [11C] DASB (2008) (0)
- Donepezil impairs memory in healthy elderly: behavioural, EEG and simultaneous EEG/fMRI biomarkers (2012) (0)
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What Schools Are Affiliated With Marc A. Laruelle?
Marc A. Laruelle is affiliated with the following schools:
