Marcel Méchali | Academic Influence

Marcel Méchali's AcademicInfluence.com Rankings

Marcel Méchali

Computer Science

#10632

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#11177

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Machine Learning

#4848

World Rank

#4905

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Artificial Intelligence

#5220

World Rank

#5291

Historical Rank

Database

#7615

World Rank

#7908

Historical Rank

computer-science Degrees

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Computer Science

Marcel Méchali's Degrees

PhD Computer Science Université Paris Cité
Bachelors Computer Science Université Paris Cité

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Why Is Marcel Méchali Influential?

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According to Wikipedia, Marcel Méchali is a molecular biologist, Research Director at the CNRS, specialist in DNA and its replication. He is in charge of the genome replication and dynamics research team at the Institut de Génétique Humaine of the CNRS of Montpellier. He was Director of this Institute from 2003 to 2006. He is also Director of Labex EpiGenMed, a network of 54 laboratories in Montpellier.

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Marcel Méchali's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin (2001) (488)
Eukaryotic DNA replication origins: many choices for appropriate answers (2010) (417)
DNA replication origin activation in space and time (2015) (395)
XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis (2000) (367)
Transition in Specification of Embryonic Metazoan DNA Replication Origins (1995) (327)
Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features. (2011) (324)
MCM proteins and DNA replication. (2006) (250)
Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos. (1993) (204)
DNA replication origins. (2006) (197)
Mitotic Remodeling of the Replicon and Chromosome Structure (2005) (192)
Lack of specific sequence requirement for DNA replication in Xenopus eggs compared with high sequence specificity in yeast (1984) (174)
MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination. (2012) (168)
Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53. (1987) (167)
New insights into replication origin characteristics in metazoans (2012) (166)
Competition between chromatin and transcription complex assembly regulates gene expression during early development (1994) (162)
Specification of a DNA replication origin by a transcription complex (2004) (162)
MCM8 Is an MCM2-7-Related Protein that Functions as a DNA Helicase during Replication Elongation and Not Initiation (2005) (142)
The chromatin environment shapes DNA replication origin organization and defines origin classes (2015) (135)
DNA replication origins: from sequence specificity to epigenetics (2001) (127)
Plasmid replication in Xenopus eggs and egg extracts: a 2D gel electrophoretic analysis. (1992) (127)
Chromotin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell‐cycle dependent and associated with the control of initiation of DNA replication. (1996) (120)
DNA synthesis in a cell-free system from Xenopus eggs: Priming and elongation on single-stranded DNA in vitro (1982) (113)
Assembly of spaced chromatin involvement of ATP and DNA topoisomerase activity. (1988) (105)
Genetic and epigenetic determinants of DNA replication origins, position and activation. (2013) (102)
A Cdt1–geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus (2006) (100)
Xenopus myc proto‐oncogene during development: expression as a stable maternal mRNA uncoupled from cell division. (1986) (98)
TFIIIC relieves repression of U6 snRNA transcription by chromatin (1993) (98)
Competition between transcription complex assembly and chromatin assembly on replicating DNA. (1990) (98)
A ‘DNA replication’ signature of progression and negative outcome in colorectal cancer (2010) (97)
Chromatin assembly on replicating DNA in vitro. (1990) (90)
Involvement of G-quadruplex regions in mammalian replication origin activity (2019) (88)
MCM9 binds Cdt1 and is required for the assembly of prereplication complexes. (2008) (85)
Comparative analysis of the intracellular localization of c-Myc, c-Fos, and replicative proteins during cell cycle progression. (1992) (84)
Assembly of spaced chromatin promoted by DNA synthesis in extracts from Xenopus eggs. (1988) (82)
Transcription complex disruption caused by a transition in chromatin structure (1991) (80)
c-Myc in the control of cell proliferation and embryonic development. (1996) (79)
H2A.ZI, a new variant histone expressed during Xenopus early development exhibits several distinct features from the core histone H2A. (1996) (77)
Dynamics of the Genome during Early Xenopus laevis Development: Karyomeres As Independent Units of Replication (1998) (76)
Translocation of a store of maternal cytoplasmic c-myc protein into nuclei during early development (1989) (75)
MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. (2011) (71)
Recombinant Cdt1 Induces Rereplication of G2 Nuclei in Xenopus Egg Extracts (2005) (71)
Vertebrate HoxB gene expression requires DNA replication (2003) (70)
Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus (2008) (70)
Stepwise Regulated Chromatin Assembly of MCM2–7 Proteins* (2000) (69)
Stathmin gene family: phylogenetic conservation and developmental regulation in Xenopus. (1993) (62)
Rearrangement of chromatin domains during development in Xenopus. (2000) (61)
Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis. (2004) (60)
Chromatin remodelling and DNA replication: from nucleosomes to loop domains (2001) (60)
Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family. (2005) (60)
HoxB domain induction silences DNA replication origins in the locus and specifies a single origin at its boundary (2006) (58)
Competence to replicate in the unfertilized egg is conferred by Cdc6 during meiotic maturation (2002) (57)
MCM9 Is Required for Mammalian DNA Mismatch Repair. (2015) (57)
Differential expression of two Xenopus c‐myc proto‐oncogenes during development. (1989) (53)
Programming DNA replication origins and chromosome organization (2010) (53)
Synergic reprogramming of mammalian cells by combined exposure to mitotic Xenopus egg extracts and transcription factors (2011) (51)
Regulated Formation of Extrachromosomal Circular DNA Molecules during Development in Xenopus laevis (1999) (49)
Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis (1997) (49)
Formation of extrachromosomal circles from telomeric DNA in Xenopus laevis (2002) (47)
Eukaryotic DNA polymerase alpha. Structural analysis of the enzyme from regenerating rat liver. (1980) (46)
Histone H4K20 tri‐methylation at late‐firing origins ensures timely heterochromatin replication (2017) (46)
A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition. (2008) (43)
DNA replication initiates at domains overlapping with nuclear matrix attachment regions in the xenopus and mouse c-myc promoter. (2004) (41)
Programming of a repressed but committed chromatin structure during early development. (1995) (40)
Stabilization and expression of high levels of p53 during early development in Xenopus laevis. (1993) (39)
In Xenopus Egg Extracts, DNA Replication Initiates Preferentially at or near Asymmetric AT Sequences (2008) (38)
Genome-scale identification of active DNA replication origins. (2012) (37)
Crystal structure of the coiled-coil dimerization motif of geminin: structural and functional insights on DNA replication regulation. (2004) (34)
A hypophosphorylated form of RPA34 is a specific component of pre-replication centers (2004) (34)
Characterization and developmental expression of Xenopus proliferating cell nuclear antigen (PCNA). (1990) (34)
A novel cell-free system reveals a mechanism of circular DNA formation from tandem repeats. (2001) (33)
Metazoan DNA replication origins. (2019) (31)
Nuclear distribution of PCNA during embryonic development in Xenopus laevis: a reinvestigation of early cell cycles. (1992) (31)
Evidence for different MCM subcomplexes with differential binding to chromatin in Xenopus. (1998) (30)
The gastrula transition reorganizes replication-origin selection in Caenorhabditis elegans (2017) (30)
Localization of c-myc expression during oogenesis and embryonic development in Xenopus laevis. (1988) (29)
Selective and rapid nuclear translocation of a c-Myc-containing complex after fertilization of Xenopus laevis eggs (1995) (29)
A functional analysis of p53 during early development of xenopus laevis (1997) (28)
A predictable conserved DNA base composition signature defines human core DNA replication origins (2020) (26)
Tumor promoter TPA increases initiation of replication on DNA injected into Xenopus eggs (1983) (26)
ORC Is Necessary at the Interphase-to-Mitosis Transition to Recruit cdc2 Kinase and Disassemble RPA Foci (2006) (25)
Mismatch repair involving localized DNA synthesis in extracts of Xenopus eggs. (1989) (24)
A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing (2013) (24)
Control of gene expression in Xenopus early development. (1998) (24)
A ‘DNA replication’ signature of progression and negative outcome in colorectal cancer (2010) (24)
Characterization and expression of a Xenopus ras during oogenesis and development. (1990) (24)
Action of the S1 endonuclease from Aspergillus oryzae on simian virus 40 supercoiled component I DNA. (1973) (23)
The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing (2019) (22)
Specification of chromatin domains and regulation of replication and transcription during development. (2000) (22)
DNA Replication Fading As Proliferating Cells Advance in Their Commitment to Terminal Differentiation (2012) (20)
Analysis of 3′‐untranslated regions of seven c‐myc genes reveals conserved elements prevalent in post‐transcriptionally regulated genes (1989) (20)
The regulation of competence to replicate in meiosis by Cdc6 is conserved during evolution (2004) (19)
of pre-replicative complexes in Xenopus laevis (2000) (19)
DNA polymerase activities in growing cells infected with simian virus 40 (1977) (18)
The Cell Cycle: Now Live and in Color (2008) (18)
Stimulation of rat liver α‐ and β‐type DNA polymerases by an homologous DNA‐unwinding protein (1977) (18)
Enhanced c-myc gene expression during forelimb regenerative outgrowth in the young Xenopus laevis. (1990) (17)
Initiation of DNA replication in eukaryotes: questioning the origin (1999) (17)
Characterization of Xenopus RalB and its involvement in F-actin control during early development. (1999) (17)
Expression of ISWI and its binding to chromatin during the cell cycle and early development. (2002) (17)
Nuclear import of p53 during Xenopus laevis early development in relation to DNA replication and DNA repair. (1999) (15)
Induction of chromosome replication during maturation of amphibian oocytes. (1983) (14)
MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors. (2019) (14)
Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites (2018) (14)
Sleeping policemen for DNA replication? (2004) (13)
DNA polymerase-α from regenerating rat liver catalytic properties of the highly purified enzyme (1979) (13)
Analysis of c-Myc and Max binding to the c-myc promoter: evidence that autosuppression occurs via an indirect mechanism. (1995) (12)
Xenopus egg extracts: a model system for chromatin replication. (1988) (12)
Co-fractionation of an endonuclease activity during the purification of DNA polymerase-alpha from regenerating rat liver. Properties and separation from DNA polymerase. (1975) (12)
Recombinant Cdt 1 Induces Rereplication of G 2 Nuclei in Xenopus Egg Extracts (2004) (10)
RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin (2017) (10)
New cell or new cycle? (2008) (10)
Involvement of both DNA polymerases α and γ in the replication of adenovirus deoxyribonucleic acid in vitro (1980) (10)
Posttranscriptional regulation of c‐myc RNA during early development of Xenopus laevis (1991) (9)
Transforming potential of the v-myb oncogene from avian myeloblastosis virus: alterations in the oncogene product may reveal a new target specificity. (1986) (9)
DNA REPLICATION AND CHROMATIN ASSEMBLY USING XENOPUS EGGS OR EMBRYOS (1999) (9)
Many roads lead to the origin (2002) (9)
How to load a replicative helicase onto chromatin: A more and more complex matter during evolution (2009) (9)
Infectivity of mengovirus replicative form. Relationship to cellular transcription. (1974) (8)
Detection of a DNA-binding factor associated with mammalian DNA polymerase-alpha. (1978) (8)
Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis (2013) (7)
DNA replication : a subject collection from Cold Spring Harbor perspectives in biology (2013) (7)
Nerve-dependent expression of c-myc protein during forelimb regeneration of Xenopus laevis froglets. (1992) (6)
Chromosome replication in early Xenopus embryos. (1985) (6)
Isolation of cDNAs from maternal mRNAs specifically present during early development (1995) (5)
Localization of ras proto‐oncogene expression during development in Xenopus Laevis (1992) (5)
Detection of proto-oncogenes in the genome of the amphibian Xenopus laevis. (1989) (5)
An improved methodology for preparation of virus-induced double stranded RNA. (1973) (5)
ANALYSIS OF CHROMOSOME REPLICATION WITH EGGS OF XENOPUS LAEVIS (1985) (5)
Structural Analysis of Eukaryotic DNA Polymerase-α (1983) (5)
Analysis of Chromatin Assembly, Chromatin Domains, and DNA Replication Using Xenopus Systems (2001) (4)
A rapid technique to separate DNA polymerase-α and -β activity from a cytosol extract (1978) (4)
Genes and mechanisms involved in early embryonic development in Xenopus laevis. (1990) (4)
Proto-oncogenes and embryonic development. (1988) (4)
Geminin is cleaved by caspase-3 during apoptosis in Xenopus egg extracts. (2007) (3)
Thermal sensitivity of eukaryotic DNA polymerase‐α and protection by its templates (1980) (3)
the SM-phase transition A topoisomerase II-dependent mechanism for resetting replicons at (2008) (3)
Characterization and expression of a xenopus ras during oogenesis and development (1989) (2)
Mitosis without DNA replication in mammalian somatic cells (2020) (2)
Proteomic data on the nuclear interactome of human MCM9 (2015) (2)
Oligonucleotide site-directed mutagenesis in Xenopus egg extracts. (1988) (2)
Production of a functional full-length Xenopus laevis c-Myc protein in insect cells. (1994) (2)
T‐antigen interactions with chromatin and p53 during the cell cycle in extracts from Xenopus eggs (1999) (2)
C-Myc Proto-Oncogene Expression During Newt Limb Regeneration (1989) (2)
Crystal Structure of the Coiled-coil Dimerization Motif of Geminin (2004) (2)
Faculty Opinions recommendation of ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis. (2013) (1)
Characteristics of Metazoan DNA Replication Origins (2015) (1)
Methods in DNA replication. (2012) (1)
Properties and Interactions of DNA Polymerase α, DNA Polymerase β and a DNA Binding Protein of Regenerating Rat Liver (1978) (1)
DNA polymerase-alpha from regenerating rat liver. Catalytic properties of the highly purified enzyme. (1979) (1)
[Replication, development and totipotency]. (2007) (1)
Vive le replicon! (1982) (1)
Faculty Opinions recommendation of Quality control in the initiation of eukaryotic DNA replication. (2012) (0)
RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin (2017) (0)
Clonage of a variant histone H2A‐Z gene and expression during development of Xenopus (1995) (0)
DNA Replication Origins, Development, and Cancer (2008) (0)
The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing (2019) (0)
Dynamics of the genome for xenopus early development (1998) (0)
Role of P53 in DNA replication during early development of Xenopus (1995) (0)
Figure 3, Changes in nuclear morphology in replicating extracts (2001) (0)
Towards prediction of predestination. Cell Interactions and Cell Differentiation: a Jacques Monod Conference sponsored by the Centre National de la Recherche Scientifique, Toulon, France, September 23-27, 1990. (1991) (0)
Author Correction: RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin (2018) (0)
Loss of Ezh2 function remodels the DNA replication initiation landscape. (2023) (0)
Replication timing and genetic instability (2022) (0)
Involvement of G-quadruplex regions in mammalian replication origin activity (2019) (0)
Author Correction: RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin (2018) (0)
In vitro site-directed mutagenesis using Xenopus egg extracts (1989) (0)
Isolation and developmental expression of an oogenesis-specific Xenopus cDNA clone (1992) (0)
Involvement of both DNA polymerases alpha and gamma in the replication of adenovirus deoxyribonucleic acid in vitro. (1980) (0)
General Discussion .1. the Role of Protooncogenes in Amphibian Development (1990) (0)
Nucleic Acids Research (0)
Faculty Opinions recommendation of The role of PR-Set7 in replication licensing depends on Suv4-20h. (2013) (0)
Comparative analysis of the intracellular localization of c-Myc, c-Fos, and replicative proteins during cell cycle progression (1992) (0)
Author Correction: Involvement of G-quadruplex regions in mammalian replication origin activity (2020) (0)
Removal of RNA by treating agarose and acrylamide gels with RNase in situ. (1988) (0)
[Role of c-myc protein in the early embryonic development of Xenopus]. (1989) (0)
Stimulation of rat liver alpha- and beta-type DNA polymerases by an homologous DNA-unwinding protein. (1977) (0)
Accelerated chromatin replication in embryonic cells (1983) (0)
A rapid technique to separate DNA polymerase-alpha and -beta activity from a cytosol extract. (1978) (0)
General Discussion .2. Regulation of the Eukaryotic Cell-Cycle (1990) (0)
Identification and Characterisation of Proteins Binding to a G-Quadruplex Origin G-rich Repeated Element in Mammalian Cells (2023) (0)
Faculty Opinions recommendation of Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen. (2013) (0)
University of Birmingham Metazoan DNA replication origins (2019) (0)
Faculty Opinions recommendation of Conserved nucleosome positioning defines replication origins. (2010) (0)
Function of C‐MYC During early Development (1995) (0)
11 DNA Replication during Animal Development and Its Relevance to Gene Expression (2006) (0)
Thermal sensitivity of eukaryotic DNA polymerase-alpha and protection by its templates. (1980) (0)
Role of maternal c-myc protein in early embryonic development (1989) (0)
Changes in rDNA replication origins after the midblastula transition in Xenopus (1995) (0)

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