Marcelo Jacobs-Lorena
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Brazilian-American molecular entomologist
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Marcelo Jacobs-Lorenabiology Degrees
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Entomology
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Molecular Biology
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Biology
Marcelo Jacobs-Lorena's Degrees
- Bachelors Biology University of São Paulo
- Masters Entomology Federal University of Rio de Janeiro
- PhD Molecular Biology Federal University of Rio de Janeiro
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Why Is Marcelo Jacobs-Lorena Influential?
(Suggest an Edit or Addition)According to Wikipedia, Marcelo Jacobs-Lorena is a Brazilian-American molecular entomologist. He is a professor in the department of molecular microbiology and immunology at Johns Hopkins Bloomberg School of Public Health. In 2002, his team loaded mosquitoes with a modified gene so that their guts produce a substance that kills off Plasmodium.
Marcelo Jacobs-Lorena's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite (2002) (271)
- Malaria Control with Genetically Manipulated Insect Vectors (2002) (260)
- Development of Transgenic Fungi That Kill Human Malaria Parasites in Mosquitoes (2011) (244)
- Fighting malaria with engineered symbiotic bacteria from vector mosquitoes (2012) (229)
- Initiation of Haemoglobin Synthesis by Methionyl-tRNA (1970) (205)
- Targeting Plasmodium ligands on mosquito salivary glands and midgut with a phage display peptide library (2001) (197)
- Bee Venom Phospholipase Inhibits Malaria Parasite Development in Transgenic Mosquitoes* (2002) (190)
- Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria (2017) (176)
- An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites. (2005) (173)
- The Plasmodium bottleneck: malaria parasite losses in the mosquito vector (2014) (172)
- The journey of the malaria parasite in the mosquito: hopes for the new century. (2000) (165)
- Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigen (2007) (160)
- Robust gut-specific gene expression in transgenic Aedes aegypti mosquitoes. (2000) (156)
- The peritrophic matrix of hematophagous insects. (2001) (153)
- A type I peritrophic matrix protein from the malaria vector Anopheles gambiae binds to chitin. Cloning, expression, and characterization. (1998) (152)
- Mosquito transgenesis: what is the fitness cost? (2006) (150)
- Genetic approaches to interfere with malaria transmission by vector mosquitoes. (2013) (149)
- Evolution of Chitin-Binding Proteins in Invertebrates (1999) (147)
- Fitness of Anopheline Mosquitoes Expressing Transgenes That Inhibit Plasmodium Development (2004) (142)
- Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle. (2015) (132)
- Using bacteria to express and display anti-Plasmodium molecules in the mosquito midgut. (2007) (129)
- The Anopheles gambiae adult midgut peritrophic matrix proteome. (2009) (124)
- Characterization of a Novel Gut-specific Chitinase Gene from the Human Malaria Vector Anopheles gambiae * (1997) (122)
- Malaria Parasite Invasion of the Mosquito Salivary Gland Requires Interaction between the Plasmodium TRAP and the Anopheles Saglin Proteins (2009) (119)
- Transgenic malaria-resistant mosquitoes have a fitness advantage when feeding on Plasmodium-infected blood (2007) (114)
- Cell-free translation of maternal messenger RNA from sea urchin eggs. (1973) (113)
- Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes (2016) (109)
- Using bacteria to express and display anti-parasite molecules in mosquitoes: current and future strategies. (2005) (107)
- Aedes aegypti peritrophic matrix and its interaction with heme during blood digestion. (2002) (106)
- Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut (2011) (97)
- Analysis of the Plasmodium and Anopheles Transcriptional Repertoire during Ookinete Development and Midgut Invasion* (2004) (91)
- Mosquito midgut barriers to malaria parasite development. (2004) (90)
- Hemolytic C-Type Lectin CEL-III from Sea Cucumber Expressed in Transgenic Mosquitoes Impairs Malaria Parasite Development (2007) (90)
- Rapid induction by a blood meal of a carboxypeptidase gene in the gut of the mosquito Anopheles gambiae. (1997) (88)
- Identification of the Aedes aegypti peritrophic matrix protein AeIMUCI as a heme-binding protein. (2006) (87)
- Messenger RNA for globin in the postribosomal supernatant of rabbit reticulocytes. (1972) (86)
- Entomopathogenic fungi as biological insecticides to control malaria. (2006) (84)
- Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion (2007) (84)
- Analysis of the Plasmodium and Anopheles Transcriptomes during Oocyst Differentiation* (2004) (84)
- Flipping the paradigm on malaria transmission-blocking vaccines. (2008) (83)
- Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges (2003) (73)
- Antibody-mediated inhibition of Aedes aegypti midgut trypsins blocks sporogonic development of Plasmodium gallinaceum (1996) (73)
- Peritrophic matrix proteins of Anopheles gambiae and Aedes aegypti (1996) (72)
- Transposon mutagenesis identifies genes essential for Plasmodium falciparum gametocytogenesis (2013) (71)
- Characterization of a carboxypeptidase A gene from the mosquito, Aedes aegypti (2000) (71)
- A cell surface mucin specifically expressed in the midgut of the malaria mosquito Anopheles gambiae. (1999) (70)
- Selective translational regulation of ribosomal protein gene expression during early development of Drosophila melanogaster. (1985) (66)
- Hemocyte differentiation mediates the mosquito late-phase immune response against Plasmodium in Anopheles gambiae (2015) (66)
- Surface-expressed enolases of Plasmodium and other pathogens. (2011) (65)
- Effect of the antimicrobial peptide gomesin against different life stages of Plasmodium spp. (2007) (65)
- Driving midgut‐specific expression and secretion of a foreign protein in transgenic mosquitoes with AgAper1 regulatory elements (2005) (64)
- Structural analysis of the Drosophila rpA1 gene, a member of the eucaryotic 'A' type ribosomal protein family. (1987) (64)
- Trypsin and aminopeptidase gene expression is affected by age and food composition in Anopheles gambiae. (1996) (64)
- The Glutathione Biosynthetic Pathway of Plasmodium Is Essential for Mosquito Transmission (2009) (64)
- Identification and characterization of a novel peritrophic matrix protein, Ae-Aper50, and the microvillar membrane protein, AEG12, from the mosquito, Aedes aegypti. (2005) (63)
- Plasmodium sporozoite invasion of the mosquito salivary gland. (2009) (61)
- Multiple pathways for Plasmodium ookinete invasion of the mosquito midgut (2014) (60)
- Developmental genetics of ribosome synthesis in Drosophila (1987) (59)
- Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions. (2005) (59)
- Translational regulation of mRNAs for ribosomal proteins during early Drosophila development. (1985) (58)
- Regulation of mRNA stability in development. (1994) (56)
- Translation of messenger RNA for histones from HeLa cells by a cell-free extract from mouse ascites tumor. (1972) (56)
- Developmental Regulation of bicoid mRNA Stability Is Mediated by the First 43 Nucleotides of the 3′ Untranslated Region (1998) (54)
- Amino acid residues involved in substrate binding and catalysis in an insect digestive β-glycosidase (2001) (54)
- Mosquito Microbiota and Implications for Disease Control. (2019) (54)
- The peritrophic matrix limits the rate of digestion in adult Anopheles stephensi and Aedes aegypti mosquitoes. (2003) (52)
- Glutathione Reductase-null Malaria Parasites Have Normal Blood Stage Growth but Arrest during Development in the Mosquito* (2010) (52)
- Genetic transformation of mosquitoes: a quest for malaria control. (2002) (50)
- A Drosophila third chromosome Minute locus encodes a ribosomal protein. (1994) (50)
- Enterobacter-Activated Mosquito Immune Responses to Plasmodium Involve Activation of SRPN6 in Anopheles stephensi (2013) (50)
- PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito (2008) (50)
- Gut‐specific genes from the black fly Simulium vittatum encoding trypsin‐like and carboxypeptidase‐like proteins (1993) (50)
- The DNA puff gene BhC4-1 of Bradysia hygida is specifically transcribed in early prepupal salivary glands of Drosophila melanogaster (1998) (48)
- Distinct Roles of Plasmodium Rhomboid 1 in Parasite Development and Malaria Pathogenesis (2009) (47)
- Insight into a Conserved Lifestyle: Protein-Carbohydrate Adhesion Strategies of Vector-Borne Pathogens (2005) (47)
- Antisense ribosomal protein gene expression specifically disrupts oogenesis in Drosophila melanogaster. (1988) (46)
- Disruption of the Plasmodium falciparum liver‐stage antigen‐1 locus causes a differentiation defect in late liver‐stage parasites (2011) (46)
- Storage and secretion of the peritrophic matrix protein Ag‐Aper1 and trypsin in the midgut of Anopheles gambiae (2004) (46)
- Fitness of transgenic Anopheles stephensi mosquitoes expressing the SM1 peptide under the control of a vitellogenin promoter. (2008) (45)
- Aedes aegypti transducing densovirus pathogenesis and expression in Aedes aegypti and Anopheles gambiae larvae (2001) (45)
- CD68 acts as a major gateway for malaria sporozoite liver infection (2015) (44)
- Complexity of RNA in eggs of Drosophila melanogaster and Musca domestica. (1980) (44)
- The role of ribosomal subunits in mammalian cells. (1969) (43)
- Production of Plasmodium falciparum gametocytes in vitro. (2013) (42)
- Cell-free Synthesis of Histories directed by Messenger RNA from Sea Urchin Embryos (1973) (40)
- Biphasic pattern of histone gene expression during Drosophila oogenesis. (1985) (40)
- Interrupting malaria transmission by genetic manipulation of anopheline mosquitoes. (2003) (40)
- Changes in rate of RNA synthesis and ribosomal gene number during oogenesis of Drosophila melanogaster. (1977) (40)
- Identification of GAPDH on the surface of Plasmodium sporozoites as a new candidate for targeting malaria liver invasion (2016) (39)
- An improved method for the in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes (2010) (39)
- Use of Microbiota to Fight Mosquito-Borne Disease (2020) (37)
- Isoprenoid Precursor Biosynthesis Is the Essential Metabolic Role of the Apicoplast during Gametocytogenesis in Plasmodium falciparum (2014) (36)
- Expression of a mutated phospholipase A2 in transgenic Aedes fluviatilis mosquitoes impacts Plasmodium gallinaceum development (2008) (36)
- Storage and secretion of Ag-Aper14, a novel peritrophic matrix protein, and Ag-Muc1 from the mosquito Anopheles gambiae (2005) (35)
- Anopheles gambiae Croquemort SCRBQ2, expression profile in the mosquito and its potential interaction with the malaria parasite Plasmodium berghei. (2009) (35)
- Peritrophic matrix of the black fly Simulium vittatum: formation, structure, and analysis of its protein components. (1994) (33)
- Immunological strategies for control of insect disease vectors: a critical assessment. (1995) (33)
- Plasmodium-mosquito interactions, phage display libraries and transgenic mosquitoes impaired for malaria transmission. (2002) (31)
- From Tucson to Genomics and Transgenics: The Vector Biology Network and the Emergence of Modern Vector Biology (2009) (31)
- Regulation of Anti-Plasmodium Immunity by a LITAF-like Transcription Factor in the Malaria Vector Anopheles gambiae (2012) (28)
- Plasmodium falciparum Maf1 Confers Survival upon Amino Acid Starvation (2017) (27)
- Characterization of a mouse ascites cell-free system. (1972) (27)
- A gut‐specific serine protease from the malaria vector Anopheles gambiae is downregulated after blood ingestion (2000) (27)
- A Type I Peritrophic Matrix Protein from the Malaria VectorAnopheles gambiae Binds to Chitin (1998) (26)
- Molecular characterization of the DNA puff C-8 gene of Rhynchosciara americana. (1993) (25)
- Cis-acting sequences in the 5'-untranslated region of the ribosomal protein A1 mRNA mediate its translational regulation during early embryogenesis of Drosophila. (1992) (24)
- Pantropic retroviral vectors mediate somatic cell transformation and expression of foreign genes in dipteran insects (1998) (24)
- Gut-specific transcriptional regulatory elements of the carboxypeptidase gene are conserved between black flies and Drosophila. (1995) (22)
- Plasmodium-Mosquito Interactions: A Tale of Roadblocks and Detours. (2010) (22)
- Gene expression in Plasmodium: from gametocytes to sporozoites. (2004) (22)
- Drosophila egg chambers develop to mature eggs when cultured in vivo. (1978) (21)
- Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites (2016) (21)
- Antimalarial Iron Chelator FBS0701 Blocks Transmission by Plasmodium falciparum Gametocyte Activation Inhibition (2014) (20)
- Control of messenger RNA stability during development. (1999) (20)
- Strategy for epitope tagging the protein-coding region of any gene. (1994) (20)
- Induction of actin gene expression in the mosquito midgut by blood ingestion correlates with striking changes of cell shape. (2007) (19)
- Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating (2021) (19)
- Genetic Control Of Malaria Mosquitoes. (2016) (19)
- Molecular strategies to study Plasmodium-mosquito interactions. (2003) (18)
- Translational regulation of a specific gene during oogenesis and embryogenesis of Drosophila. (1983) (18)
- A natural symbiotic bacterium drives mosquito refractoriness to Plasmodium infection via secretion of an antimalarial lipase (2021) (18)
- The site of action of inhibitors of initiation of protein synthesis in reticulocytes. (1972) (18)
- Generation of Minute phenotypes by a transformed antisense ribosomal protein gene. (1992) (18)
- Dosage of 5 S and ribosomal genes during oogenesis of Drosophila melanogaster. (1980) (17)
- Determinants of Drosophila fushi tarazu mRNA instability (1996) (17)
- Transgenic Mosquitoes Expressing a Phospholipase A2 Gene Have a Fitness Advantage When Fed Plasmodium falciparum-Infected Blood (2013) (16)
- The black fly Simulium vittatum trypsin gene: characterization of the 5'-upstream region and induction by the blood meal. (1995) (16)
- Functional and biochemical modifications in skeletal muscles from malarial mice (2005) (16)
- Translational Regulation of Ribosomal Protein Gene Expression in Eukaryotes (1987) (16)
- A study of ribosomal subunits during cell-free protein synthesis. (1970) (16)
- Towards the genetic control of insect vectors: An overview (2007) (16)
- Nuclear factor recognition sites in the gut-specific enhancer region of an Anopheles gambiae trypsin gene. (1998) (15)
- Studies on the translational control of histone synthesis. I. Translation of histone messenger RNA by heterologous cell-free systems prepared from cells inactive in DNA synthesis. (1973) (14)
- Amino acid residues involved in substrate binding and catalysis in an insect digestive beta-glycosidase. (2000) (14)
- Paratransgenesis Applications: Fighting Malaria With Engineered Mosquito Symbiotic Bacteria (2017) (14)
- Mass fractionation of Drosophila egg chambers. (1977) (14)
- Transcriptional profiling and physiological roles of Aedes aegypti spermathecal-related genes (2020) (13)
- CXCR4 regulates Plasmodium development in mouse and human hepatocytes (2019) (13)
- Inhibition of protein synthesis in reticulocytes by antibiotics. V. Mechanism of action of pederine, an inhibitor of initiation and elongation. (1971) (13)
- Preferential expression of actin genes during oogenesis of Drosophila. (1984) (12)
- The response of Plasmodium falciparum to isoleucine withdrawal is dependent on the stage of progression through the intraerythrocytic cell cycle (2020) (12)
- Field assessment of potential sugar feeding stations for disseminating bacteria in a paratransgenic approach to control malaria (2018) (11)
- Evaluation of drive mechanisms (including transgenes and drivers) in different environmental conditions and genetic backgrounds (2005) (11)
- Identification and germline transformation of the ribosomal protein rp21 gene of Drosophila: Complementation analysis with the Minute QIII locus reveals nonidentity (1988) (11)
- Complexity of RNA in developing oocytes of Drosophila melanogaster. (1980) (11)
- The fibrinolytic system enables the onset of Plasmodium infection in the mosquito vector and the mammalian host (2021) (10)
- Translational discrimination of ribosomal protein mRNAs in the early Drosophila embryo. (1991) (8)
- Targeting molecular interactions essential for Plasmodium sexual reproduction (2015) (8)
- Malaria parasite Pfs47 disrupts JNK signaling to escape mosquito immunity (2015) (8)
- Identification of Plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infection (2018) (7)
- Functional Mapping of Destabilizing Elements in the Protein-coding Region of the Drosophila fushi tarazumRNA* (2001) (7)
- Targeting essential Eimeria ninakohlyakimovae sporozoite ligands for caprine host endothelial cell invasion with a phage display peptide library (2015) (6)
- Identification of species-specific DNA sequences in North American blackflies. (1988) (6)
- CHAIN TERMINATION: A TEST FOR A POSSIBLE EXPLANATION OF THALASSEMIA * (1969) (6)
- In Vitro Differentiation of Plasmodium falciparum Gametocytes into Ookinetes. (2013) (5)
- Self-limiting paratransgenesis (2020) (5)
- Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites (2022) (5)
- Correction: The Glutathione Biosynthetic Pathway of Plasmodium Is Essential for Mosquito Transmission (2009) (5)
- Genetic approaches for malaria control (2005) (4)
- Transgenic mosquitoes for malaria control: progresses and challenges (2003) (4)
- Developmental regulation of an instability element from the Drosophila fushi tarazu mRNA (2001) (3)
- Overproduction and translational regulation of rp49 ribosomal protein mRNA in transgenic Drosophila carrying extra copies of the gene (1990) (3)
- Inhibition of protein synthesis in reticulocytes by antibiotics. IV. Ribosome behaviour after puromycin release of growing peptide chains. (1970) (3)
- Isolation of plasma membranes from Drosophila embryos (2004) (2)
- Combining transgenesis with paratransgenesis to fight malaria (2022) (2)
- Cell-free synthesis of histones directed by messenger RNA from sea urchin embryos. (1973) (2)
- Erratum: A gut-specific serine protease from the malaria vector Anopheles gambiae is downregulated after blood ingestion (Insect Molecular Biology 9 (223-229)) (2001) (2)
- Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission (2022) (2)
- And Effectively Transmit Dengue Virus Even at Malaria Control with Genetically Manipulated Insect Vectors (1)
- A Plasmodium key fits a mosquito lock (2020) (1)
- What are relevant assays for refractoriness (2005) (1)
- A Genetically Modified Anti-Plasmodium Bacterium Is Harmless to the Foragers of the Stingless Bee Partamona helleri (2021) (1)
- Investigation of plasmodium vivax rhomboid-like protease 1 compared to plasmodium falciparum rhomboid protease 1 in erythrocytic cycle (2018) (1)
- Initiation of histone synthesis by f-met-tRNAf in an ascites cell-free system (1973) (1)
- Identification of Antimalarial Compounds that Inhibit Apicomplexan AP2 Proteins (2022) (1)
- Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes (2021) (1)
- Quantitation of individual proteins by a two-stage electrophoresis procedure. (1982) (1)
- FMRF-related peptides in Aedes aegypti midgut: neuromuscular connections and enteric nervous system (2021) (1)
- A Genetically Modified Anti-Plasmodium Bacterium Is Harmless to the Stingless Bee Partamona Helleri (2021) (1)
- Abrupt decline in the rate of accumulation of total protein and yolk in postvitellogenic egg chambers ofDrosophila (1983) (1)
- STABILITY IN DEVELOPMENT (1994) (1)
- Fighting malaria with engineered mosquito symbiotic bacteria (2018) (0)
- Regulation of ribosomal protein messenger RNA translation during early development of Drosophila (1989) (0)
- Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways (2022) (0)
- Interference of gene expression in Drosophila by antisense ribosomal protein genes integrated into the germ line. (1992) (0)
- The Screen of a Phage Display Library Identifies a Peptide That Binds to the Surface of Trypanosoma cruzi Trypomastigotes and Impairs Their Infection of Mammalian Cells (2022) (0)
- Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites (2016) (0)
- Targeting essential Eimeria ninakohlyakimovae sporozoite ligands for caprine host endothelial cell invasion with a phage display peptide library (2015) (0)
- Erratum: Nuclear factor recognition sites in the gut-specific enhancer region of an Anopheles gambiae trypsin gene (Insect Biochemistry and Molecular Biology 28;12 (1007-1012) PII: S0965174898000897) (1999) (0)
- Selective translational regulation of ribosomal protein gene expression during early development of Drosophila melanogaster (1985) (0)
- Single-Cell Transcriptomics To Define Plasmodium falciparum Stage Transition in the Mosquito Midgut (2022) (0)
- Plasmodium vivax rhomboid-like protease 1 gene diversity in Thailand (2017) (0)
- The Plasmodium bottleneck: malaria parasite losses in the mosquito vector. (2014) (0)
- In the news (2007) (0)
- Genetic Investigation of T ricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle Graphical Abstract Highlights (2015) (0)
- Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission (2022) (0)
- New weapons to fight malaria transmission: A historical view (2022) (0)
- Field assessment of potential sugar feeding stations for disseminating bacteria in a paratransgenic approach to control malaria (2018) (0)
- Introduction of the Keynote Speaker (2016) (0)
- Factor H-mediated complement evasion by the infective sporozoite stages of the malaria parasite Plasmodium falciparum (2017) (0)
- PLASMODIUM FALCIPARUM TRANSMISSION‐BLOCKING PROTEINS SECRETED FROM BACTERIA IN THE MOSQUITO MIDGUT (2011) (0)
- Identification of symbionts in Spiroplasma insolitum Anopheles gambiae (2017) (0)
- development of Drosophila melanogaster. protein gene expression during early Selective translational regulation of ribosomal (2013) (0)
- Cell-Free Translation of Maternal Messenger RNA from Sea Urchin Eggs ( histones / cell-free synthesis ) (0)
- Labeling of mitochondria in live pbgccs− oocysts using MitoTracker Red. (2013) (0)
- Book Reviews (1915) (0)
- Effective Oral RNA Interference (RNAi) Administration to Adult Anopheles gambiae Mosquitoes. (2022) (0)
- A Genetically Modified Anti-Plasmodium Bacterium Is Harmless to the Foragers of the Stingless Bee Partamona helleri (2021) (0)
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What Schools Are Affiliated With Marcelo Jacobs-Lorena?
Marcelo Jacobs-Lorena is affiliated with the following schools:
