Marcia C. Haigis
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Marcia C. Haigis's Degrees
- Bachelors Biology University of California, San Diego
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(Suggest an Edit or Addition)Marcia C. Haigis's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mammalian sirtuins: biological insights and disease relevance. (2010) (1797)
- Mitochondria and Cancer (2016) (1744)
- Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway (2013) (1473)
- Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. (2006) (1274)
- Pancreatic cancers require autophagy for tumor growth. (2011) (1267)
- Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007) (1116)
- SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells (2006) (1084)
- PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation to promote metastasis (2014) (759)
- SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. (2011) (733)
- The multifaceted contributions of mitochondria to cellular metabolism (2018) (662)
- Calorie restriction extends yeast life span by lowering the level of NADH. (2004) (646)
- SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle (2009) (640)
- Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon (2008) (560)
- Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. (2010) (551)
- The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4 (2013) (482)
- The aging stress response. (2010) (467)
- SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. (2013) (375)
- Corrigendum: PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis (2014) (351)
- Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State (2012) (345)
- Short-term calorie restriction enhances skeletal muscle stem cell function. (2012) (337)
- Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity (2011) (320)
- Accumulation of succinate controls activation of adipose tissue thermogenesis (2018) (298)
- SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. (2012) (294)
- Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass (2017) (249)
- Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. (2011) (237)
- SIRT3 regulation of mitochondrial oxidative stress (2013) (235)
- A metabolic prosurvival role for PML in breast cancer. (2012) (233)
- Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. (2016) (233)
- Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity (2020) (224)
- Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells (2014) (214)
- Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization (2016) (211)
- Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate (2019) (209)
- The coordination of nuclear and mitochondrial communication during aging and calorie restriction (2009) (204)
- From Sirtuin Biology to Human Diseases: An Update* (2012) (203)
- Mitochondrial Sirtuins and Molecular Mechanisms of Aging. (2017) (186)
- Acetylation-Dependent Regulation of Skp2 Function (2012) (183)
- Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma (2018) (183)
- Superoxide Dismutase 1 Knock-down Induces Senescence in Human Fibroblasts* (2003) (176)
- Translocation of a beta-peptide across cell membranes. (2002) (170)
- Suppression by TFR cells leads to durable and selective inhibition of B cell effector function (2016) (168)
- SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. (2012) (165)
- Ribonuclease inhibitor: structure and function. (2005) (164)
- Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. (2004) (148)
- Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism (2021) (136)
- Ribonuclease inhibitor as an intracellular sentry. (2003) (120)
- Sirtuins regulate key aspects of lipid metabolism. (2010) (117)
- SIRT4 Represses Peroxisome Proliferator-Activated Receptor α Activity To Suppress Hepatic Fat Oxidation (2013) (114)
- HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS (2013) (111)
- Metabolic modeling of single Th17 cells reveals regulators of autoimmunity (2021) (110)
- Metabolic regulation by SIRT3: implications for tumorigenesis. (2012) (108)
- SIRT4 Protein Suppresses Tumor Formation in Genetic Models of Myc-induced B Cell Lymphoma* (2013) (102)
- PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. (2016) (101)
- Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. (2015) (99)
- Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction (2012) (99)
- Regulation of RAS oncogenicity by acetylation (2012) (95)
- The aging lung: Physiology, disease, and immunity (2021) (91)
- Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway (2003) (86)
- T Cell Activation Depends on Extracellular Alanine. (2019) (83)
- A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels (2013) (82)
- SIRT1 Shows No Substrate Specificity in Vitro* (2005) (77)
- mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors. (2017) (74)
- Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis (2014) (69)
- Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice (2018) (66)
- Nuclear respiratory factor 2 induces SIRT3 expression (2015) (61)
- Role of sirtuins and calorie restriction in neuroprotection: implications in Alzheimer's and Parkinson's diseases. (2011) (59)
- Sirtuins and the Metabolic Hurdles in Cancer (2015) (59)
- SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1 (2014) (58)
- Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. (2020) (54)
- SIRT 5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle Citation (52)
- Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity. (2021) (52)
- Nitrogen Metabolism in Cancer and Immunity. (2020) (51)
- Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism (2015) (50)
- Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3 (2018) (50)
- Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review (2014) (48)
- Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming. (2019) (43)
- Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells (2020) (42)
- Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. (2013) (42)
- Localized metabolomic gradients in patient-derived xenograft models of glioblastoma. (2019) (39)
- Mitochondria: Their relevance during oocyte ageing (2021) (38)
- Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. (2018) (37)
- KFERQ Sequence in Ribonuclease A-mediated Cytotoxicity* (2002) (36)
- The Protein Deacetylase SIRT3 Prevents Oxidative Stress-induced Keratinocyte Differentiation* (2013) (28)
- Evolution of ribonuclease inhibitor by exon duplication. (2002) (27)
- Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. (2002) (26)
- REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors (2020) (26)
- The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function (2020) (26)
- Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3 (2018) (26)
- Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells. (2022) (24)
- Chemical and Physiological Features of Mitochondrial Acylation. (2018) (24)
- SIRT4 Is a Regulator of Insulin Secretion. (2017) (22)
- l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism (2018) (22)
- Oncogenes and Tumor Suppressors HDAC 6 and SIRT 2 Regulate the Acetylation State and Oncogenic Activity of Mutant KRAS (2013) (21)
- Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function (2022) (20)
- Intersections between mitochondrial sirtuin signaling and tumor cell metabolism (2015) (20)
- The effects of age and systemic metabolism on anti-tumor T cell responses (2020) (18)
- Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis (2021) (18)
- PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. (2020) (17)
- SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis. (2021) (15)
- An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues (2017) (15)
- In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity (2020) (13)
- Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway (2020) (11)
- SIRT4 controls the balance between lipid synthesis and catabolism by repressing malonyl-CoA decarboxylase (2012) (10)
- Sirtuins in Aging and Age-Related Diseases (2011) (9)
- The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4 (2021) (8)
- Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter. (2014) (8)
- Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway (2013) (8)
- Metabolomic and Transcriptomic Signatures of Chemogenetic Heart Failure. (2022) (7)
- Sweet Temptation: From Sugar Metabolism to Gene Regulation. (2019) (6)
- Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway (2020) (6)
- New editorial board members (2018) (5)
- Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins (2021) (5)
- Metabolic Competition in the Tumor Microenvironment (2020) (5)
- Leveraging insights into cancer metabolism—a symposium report (2019) (3)
- Strength in numbers: Phosphofructokinase polymerization prevails in the liver (2017) (3)
- Dangerous dynamic duo: Lactic acid and PD-1 blockade. (2022) (3)
- Accumulation of succinate controls activation of adipose tissue thermogenesis (2018) (3)
- The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for proper mitochondrial function (2019) (2)
- Mitochondrial Sirtuins: Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks (2018) (2)
- Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome (2022) (2)
- Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming (2018) (2)
- Metabolic analyses reveal dysregulated NAD+ metabolism and altered mitochondrial state in ulcerative colitis (2022) (1)
- Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia (2021) (1)
- Leading Edge Review Mitochondria and Cancer (2016) (1)
- The role of SIRT3 in regulating cancer cell metabolism (2012) (1)
- PHD3 controls energy homeostasis and exercise capacity (2019) (1)
- Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice. (2021) (1)
- Age-associated remodeling of T cell immunity and metabolism. (2022) (1)
- Spatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers (2022) (1)
- Sirtuins and Metabolic Regulation (2015) (1)
- Sirtuins in Cancer – Emerging Role as Modulators of Metabolic Reprogramming (2016) (0)
- Abstract PR04: Transcriptional regulation of mitochondrial metabolism by TIF1γ drives erythroid progenitor differentiation (2020) (0)
- Low level of MtDNA mutation promotes mitochondrial bioenergetics and oxidative metabolism via retrograde signaling (2012) (0)
- A metabolomic signature of the APOE2 allele (2022) (0)
- The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate (2019) (0)
- Regulation of metabolism by sirtuins (2012) (0)
- The Role of Mitochondria in Aging and Cancer (2021) (0)
- Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1γ Drives Erythropoiesis (2019) (0)
- Bioinformatic and molecular investigation of Sirt3 expression (2012) (0)
- Sirt3 affects the function and stability of OXPHOS complexes in response to metabolic challenges (2012) (0)
- The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance (2019) (0)
- Abstract 5149: Age-associated remodeling of anti-tumor T cell immunity and metabolism (2023) (0)
- NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer. (2023) (0)
- An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues (2017) (0)
- Altered metabolic requirements in cancer cell migration and metastasis (2012) (0)
- A novel DNAJ protein, TCAIM, drives proteolysis of α-ketoglutarate dehydrogenase and regulates mitochondrial metabolism. (2022) (0)
- Abstract 1156: GUK1 is a novel metabolic liability in oncogene-driven lung cancer (2023) (0)
- Novel regulation of fat metabolism in cancer (2015) (0)
- Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report. (2023) (0)
- Compositions et méthodes de modulation de l'hydroxylation d'acc2 par phd3 (2016) (0)
- A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels (2013) (0)
- 81 Proffered Paper: Regulation of Cellular Metabolism by Cancer Genes – Implications in Breast Cancer (2012) (0)
- FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity (2023) (0)
- Abstract A19: PD-1 modulation promotes antitumor immunity by improving metabolic fitness of both PD-1+ and PD-1- CD8+ T cells in the tumor (2018) (0)
- SIRT4 represses Myc-induced B cell lymphomagenesis SIRT4 suppresses tumor formation in genetic models of Myc-induced B cell lymphoma (2013) (0)
- network identifies SIRT 3-ATP synthase association d SIRT 3 binds ATP 5 O in a stress-and pH-sensitive manner d SIRT 3 links fuel utilization with membrane potential homeostasis (2016) (0)
- Abstract PR9: Loss of PD-1 promotes antitumor immunity by improving functions of both PD-1+ and PD-1- CD8+ T cells in the tumor microenvironment (2020) (0)
- Drug adaptation influences cardiotoxicity caused by tyrosine kinase inhibitors in iPSC-derived human cardiomyocytes (2018) (0)
- Cellular metabolic response to DNA damage (2012) (0)
- TRANSCRIPTOMIC AND METABOLOMIC SIGNATURES OF CHEMOGENETIC HEART FAILURE (2021) (0)
- P10 - Sirtuins in Stress Response (2015) (0)
- Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis. (2023) (0)
- Mitochondrial Sirtuins Regulate Protein Networks to Orchestrate the Stress Response (2017) (0)
- The multifaceted contributions of mitochondria to cellular metabolism (2018) (0)
- Abstract 3680: Multiomics analysis of triple negative breast cancer identifies potential metabolic vulnerability for overcoming the resistance of neoadjuvant therapy (2023) (0)
- FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. (2023) (0)
- 2021 – TRANSCRIPTIONAL REGULATION OF MITOCHONDRIAL METABOLISM BY TIF1GAMMA DRIVES ERYTHROID PROGENITOR DIFFERENTIATION (2020) (0)
- FOXC2, Goosecoid, SIP1, Slug, Snail and Twist Induce EMT in Human Breast Cancer Cell Lines Through a Regulatory Network (2005) (0)
- New roles for sirtuins in mitochondrial metabolism (2010) (0)
- The role of mitochondria in aging. (2018) (0)
- Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism (2021) (0)
- Characterization of metabolic compartmentalization in the liver using spatially resolved metabolomics (2021) (0)
- Abstract IA09: Metabolic recycling in cancer (2018) (0)
- 1038 Loss of PD-1 signals improves CD8+ TIL function in a cell intrinsic and cell extrinsic manner (2022) (0)
- Women in metabolism: part I. (2015) (0)
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