Maree Smith

Q: What Schools Are Affiliated With Maree Smith

Maree Smith is affiliated with the following schools: University of Queensland, University of Melbourne, Monash University

Maree Smith's AcademicInfluence.com Rankings

Maree Smith

Chemistry

#5304

World Rank

#6461

Historical Rank

chemistry Degrees

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Chemistry

Maree Smith's Degrees

Masters Pharmacy University of Melbourne

Why Is Maree Smith Influential?

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According to Wikipedia, Maree Therese Smith is an Australian researcher, inventor and innovator based at the University of Queensland. She is executive director of the Centre for Integrated Preclinical Drug Development, and TetraQ , head of the Pain Research Group in the UQ School of Pharmacy, and the inventor and developer of a potential novel treatment for chronic pain, EMA401.

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Maree Smith's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. (2012) (250)
Bioerodable PLGA-Based Microparticles for Producing Sustained-Release Drug Formulations and Strategies for Improving Drug Loading (2016) (242)
The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes. (2003) (229)
Morphine-3-glucuronide--a potent antagonist of morphine analgesia. (1990) (224)
The intrinsic antinociceptive effects of oxycodone appear to be κ-opioid receptor mediated (1997) (222)
Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN) (2013) (216)
Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation (2012) (215)
Oxycodone and morphine have distinctly different pharmacological profiles: Radioligand binding and behavioural studies in two rat models of neuropathic pain (2007) (178)
Morphine-3-Glucuronide — A potent antagonist of morphine analgesia (1990) (175)
The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices (2002) (161)
Neurotrophins and Neuropathic Pain: Role in Pathobiology (2015) (148)
Single‐dose and steady‐state pharmacokinetics and pharmacodynamics of oxycodone in patients with cancer (1992) (140)
An Update on the Pharmacological Management of Post-Herpetic Neuralgia and Painful Diabetic Neuropathy (2008) (109)
Pharmacokinetics and Pharmacodynamics of Oxycodone When Given Intravenously and Rectally to Adult Patients with Cancer Pain (1995) (100)
Morphine-3-glucuronide: evidence to support its putative role in the development of tolerance to the antinociceptive effects of morphine in the rat (1995) (100)
Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models (2013) (97)
Dose‐dependent pharmacokinetics of caffeine in humans: Relevance as a test of quantitative liver function (1990) (94)
ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO (2012) (92)
A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. (2010) (91)
Comparative Oxycodone Pharmacokinetics in Humans After Intravenous, Oral, and Rectal Administration (1992) (88)
Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats (2000) (87)
Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere. (2016) (80)
Small molecule angiotensin II type 2 receptor (AT₂R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats. (2013) (80)
Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression (2018) (77)
Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial (2011) (75)
Anti-allodynic efficacy of the χ-conopeptide, Xen2174, in rats with neuropathic pain (2005) (73)
Synthesis and biological evaluation of an orally active glycosylated endomorphin-1. (2012) (67)
chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. (2009) (66)
A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia. (2013) (63)
Quantitation of Morphine, Morphine‐3‐Glucuronide, and Morphine‐6‐Glucuronide in Plasma and Cerebrospinal Fluid Using Solid‐Phase Extraction and High‐Performance Liquid Chromatography with Electrochemical Detection (1994) (61)
Morphine-3-Glucuronide’s Neuro-Excitatory Effects Are Mediated via Indirect Activation of N-Methyl-d-Aspartic Acid Receptors: Mechanistic Studies in Embryonic Cultured Hippocampal Neurones (2003) (60)
Pain, analgesia and genetics (2011) (53)
SEX DIFFERENCES IN THE PHARMACOKINETICS, OXIDATIVE METABOLISM AND ORAL BIOAVAILABILITY OF OXYCODONE IN THE SPRAGUE‐DAWLEY RAT (2008) (52)
Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain (2018) (52)
High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. (2012) (51)
Determination of the Serum Protein Binding of Oxycodone and Morphine Using Ultrafiltration (1993) (50)
Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies (2016) (44)
Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments (2013) (43)
Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. (2012) (43)
Differences between and combinations of opioids re-visited (2008) (42)
The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation (2013) (41)
Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain. (2014) (40)
Analgesic tolerance to opioids (2001) (39)
Inhibition of acid‐sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain (2018) (39)
Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain (2015) (36)
The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats (2016) (36)
Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry. (2005) (35)
Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern? (2013) (34)
ANTINOCICEPTION VERSUS SERUM CONCENTRATION RELATIONSHIPS FOLLOWING ACUTE ADMINISTRATION OF INTRAVENOUS MORPHINE IN MALE AND FEMALE SPRAGUE‐DAWLEY RATS: DIFFERENCES BETWEEN THE TAIL FLICK AND HOT PLATE NOCICEPTIVE TESTS (2009) (33)
Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain (2014) (33)
Lipo-Endomorphin-1 Derivatives with Systemic Activity against Neuropathic Pain without Producing Constipation (2012) (31)
Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signaling in the dorsal horn of the spinal cord (2015) (29)
Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management. (2010) (28)
Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models of Alzheimer's disease (2014) (28)
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods (2014) (28)
Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months. (2011) (28)
Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioral, pharmacological, radiological, histological and immunohistochemical methods (2013) (28)
The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients (2016) (28)
Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain (2004) (27)
Comparison of Burrowing and Stimuli-Evoked Pain Behaviors as End-Points in Rat Models of Inflammatory Pain and Peripheral Neuropathic Pain (2016) (27)
Comparison of the Pharmacokinetics of Oxycodone and Noroxycodone in Male Dark Agouti and Sprague–Dawley Rats: Influence of Streptozotocin-Induced Diabetes (2005) (27)
Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy (2014) (25)
In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla (2015) (25)
Pregabalin for the treatment of fibromyalgia (2012) (24)
Quantitation of Oxycodone in Human Plasma Using High‐Performance Liquid Chromatography with Electrochemical Detection (1991) (24)
Sustained-release ketamine-loaded nanoparticles fabricated by sequential nanoprecipitation. (2020) (23)
Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. (2007) (23)
Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: A mini review (2014) (22)
Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: potential application to biomolecular screening. (2004) (21)
Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) for determination of risedronate concentrations in human plasma. (2012) (21)
Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants (2020) (20)
Cyclooctatetraene: A Bioactive Cubane Paradigm Complement. (2019) (19)
Fully validated LC-MS/MS method for quantification of homocysteine concentrations in samples of human serum: a new approach. (2014) (19)
In vitro methods for hazard assessment of industrial chemicals – opportunities and challenges (2015) (19)
The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain (2018) (19)
Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain. (2015) (18)
Effects of long-term opioid analgesics on cognitive performance and plasma cytokine concentrations in patients with chronic low back pain: a cross-sectional pilot study (2018) (17)
Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data (2018) (17)
The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. (2019) (16)
Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation. (2013) (16)
Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure. (2015) (15)
The furoxan nitric oxide donor, PRG150, evokes dose‐dependent analgesia in a rat model of painful diabetic neuropathy (2015) (15)
Establishment and Characterization of a Novel Rat Model of Mechanical Low Back Pain Using Behavioral, Pharmacologic and Histologic Methods (2017) (15)
Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats. (2011) (14)
Optimization and In Vivo Profiling of a Refined Rat Model of Walker 256 Breast Cancer Cell-Induced Bone Pain Using Behavioral, Radiological, Histological, Immunohistochemical and Pharmacological Methods (2017) (14)
Endomorphin analogues with mixed μ-opioid (MOP) receptor agonism/δ-opioid (DOP) receptor antagonism and lacking β-arrestin2 recruitment activity. (2014) (13)
Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A(2-17) following spinal and supraspinal routes of administration (2009) (12)
Attenuation of the Infiltration of Angiotensin II Expressing CD3+ T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia – A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT2) Receptor Antagonist (2017) (12)
Sustained-Release Hydromorphone Microparticles Produced by Supercritical Fluid Polymer Encapsulation. (2019) (12)
Clinical pharmacology and adverse effects (1999) (12)
Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin‐induced peripheral neuropathy (2018) (11)
In Vitro Metabolic Stability and in Vivo Biodistribution of 3-Methyl-4-furoxancarbaldehyde Using PET Imaging in Rats. (2016) (10)
Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. (2020) (10)
Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration. (2007) (9)
A novel fully validated LC-MS/MS method for quantification of pyridoxal-5'-phosphate concentrations in samples of human whole blood. (2015) (9)
Formulation of Bioerodible Ketamine Microparticles as an Analgesic Adjuvant Treatment Produced by Supercritical Fluid Polymer Encapsulation (2018) (9)
Evaluation of a High-Throughput Peptide Reactivity Format Assay for Assessment of the Skin Sensitization Potential of Chemicals (2016) (9)
Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine. (2020) (8)
J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain. (2019) (8)
Faculty Opinions recommendation of A1899, PK-THPP, ML365, and Doxapram inhibit endogenous TASK channels and excite calcium signaling in carotid body type-1 cells. (2020) (7)
Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models (2013) (7)
Simple and reliable determination of bromazepam in human plasma by high-performance liquid chromatography (1985) (7)
Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats (1998) (7)
Use of Microfluidics to Fabricate Bioerodable Lipid Hybrid Nanoparticles Containing Hydromorphone or Ketamine for the Relief of Intractable Pain (2020) (6)
TRANSLATIONAL RESEARCH SECTION Original Research Article Small Molecule Angiotensin II Type 2 Receptor (AT2R) Antagonists as Novel Analgesics for Neuropathic Pain: Comparative Pharmacokinetics, Radioligand Binding, and Efficacy in Rats (2016) (6)
The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. (2003) (6)
In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile. (2020) (6)
Morphine hyposensitivity in streptozotocin‐diabetic rats: Reversal by dietary l‐arginine treatment (2018) (6)
An improved liquid chromatography tandem mass spectrometry (LC-MS/MS) method for quantification of dexmedetomidine concentrations in samples of human plasma. (2018) (6)
Bioerodable Ketamine-Loaded Microparticles Fabricated Using Dissolvable Hydrogel Template Technology. (2019) (6)
Oxycodone has a distinctly different pharmacology from morphine (2001) (6)
Pain pharmacology and the pharmacological management of pain (2014) (6)
High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC-MS/MS instrumentation. (2016) (6)
STUDIES WITH KETAMINE AND ALFENTANIL FOLLOWING FREUND'S COMPLETE ADJUVANT‐INDUCED INFLAMMATION IN RATS (2007) (6)
Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources (2022) (6)
Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain (2020) (6)
Modelling Parkinson's Disease in rats (2007) (6)
What Does Pain Hurt? (2009) (6)
Nitric oxide modulates μ‐opioid receptor function in vitro (2019) (6)
The role of morphine-6-glucuronide (M6G) in pain control (2001) (6)
Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls. (2018) (6)
The Cancer Patient with Anxiety and Chronic Pain (2009) (5)
Co-administration of oxycodone and morphine and analgesic synergy re-examined. (2005) (5)
Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain (2017) (5)
In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: Between‐colony differences in Sprague Dawley rats (2018) (5)
Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint (2021) (5)
Assessment of the Anti-Allodynic and Anti-Hyperalgesic Efficacy of a Glycine Transporter 2 Inhibitor Relative to Pregabalin, Duloxetine and Indomethacin in a Rat Model of Cisplatin-Induced Peripheral Neuropathy (2021) (4)
An improved LC-MS/MS method for simultaneous evaluation of CYP2C9, CYP2C19, CYP2D6 and CYP3A4 activity. (2018) (4)
In vivo proof-of-concept study: Commercialisation and regulatory imperatives (2005) (4)
Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods (2018) (3)
Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments (2013) (3)
Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat (2021) (2)
Faculty Opinions recommendation of Bias factor and therapeutic window correlate to predict safer opioid analgesics. (2020) (2)
Optimisation of a Microfluidic Method for the Delivery of a Small Peptide (2021) (2)
Ultrasonography in Pain Medicine : Opening the Third Eye (2012) (2)
Current developments in MRI for assessing rodent models of multiple sclerosis (2014) (2)
Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell‐induced bone pain (2019) (2)
Abstract A17: The dual angiogenesis/heparanase inhibitor PG545 inhibits solid tumor progression in models of breast, prostate and liver cancer: A comparative assessment of once versus twice weekly administration schedules (2009) (2)
Urologic Chronic Pelvic Pain Syndromes (2013) (1)
14 Opioid Analgesics (2012) (1)
Cost-effectiveness of motivational enhancement therapy with and without cognitive behaviour therapy for type 1 diabetes (2009) (1)
Opioid-induced hyperalgesia, opioid rotation and opioid combinations (2008) (1)
Assessment of working spatial memory utilising T-maze and Morris water-maze for the study of a rodent model of alzheimer's disease (2004) (1)
Changing hand appearance using visual illusions modulates body perception disturbance and pain in longstanding Complex Regional Pain Syndrome: A randomised trial (2020) (1)
Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial. (2022) (1)
Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy (2018) (1)
Corrigendum: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere. (2018) (1)
Absence of antinociceptive cross-tolerance between supraspinal oxycodone and intravenous morphine in the dark agouti rat (2000) (1)
Pain pharmacology and analgesia (2008) (1)
Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease (2020) (1)
Pharmacogenetics of Pain (2013) (1)
Is Morphine Superior to Fentanyl for Analgesia during Extracorporeal Membrane Oxygenation in Adult Patients (2012) (1)
Neuromodulation in Primary Headaches (2011) (1)
Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. (2022) (1)
Differential changes in the potency of supraspinally administered oxycodone relative to morphine for the alleviation of tactile allodynia in adult male Dark Agouti rats with streptozotocin-induced diabetes (2001) (1)
Anti-allodynic efficacy of the x-conipeptide, MR1A, in rats with neuropathic pain (2002) (1)
Longitudinal investigation of the antinociceptive potency of oxycodone and morphine in the zucker rat (2003) (1)
Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods (2019) (1)
Faculty Opinions recommendation of Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats. (2020) (1)
Editorial: Verification of Animal Pain Models by Reverse Translation (2021) (1)
Innovation in drug development (2009) (1)
Determination of morphine, M3G, M6G, oxycodone and their N-demethylated metabolites in biological fluids, using HPLC-MS/MS (2000) (1)
Faculty Opinions recommendation of Effects of the ventilatory stimulant, doxapram on human TASK-3 (KCNK9, K2P9.1) channels and TASK-1 (KCNK3, K2P3.1) channels. (2020) (1)
Faculty Opinions recommendation of Morphine-induced respiratory depression is independent of β-arrestin2 signalling. (2020) (1)
Faculty Opinions recommendation of Averting Opioid-induced Respiratory Depression without Affecting Analgesia. (2020) (0)
Preclinical development of new drugs for pain treatment (2008) (0)
Additive Antinociception Following Co-administration of a NR2B-Selective NMDA Antagonist with BDNF (2007) (0)
M3G's neuro-excitatory side-effects are mediated pre-synaptically: Mechanistic studies implicating dynorphin A. (2001) (0)
Faculty Opinions recommendation of Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects. (2021) (0)
Comparative pharmacokinetics and metabolism of subcutaneous oxycodone in male dark agouti relative to sprague-dawley rats (2004) (0)
Serum 17 -oestradiol concentrations are directly correlated with the time to reach peak antinociception in oestradiol-pretreated rats administered prolonged intravenous morphine infusions (2002) (0)
Faculty Opinions recommendation of Inhibition of protein kinase A and GIRK channel reverses fentanyl-induced respiratory depression. (2020) (0)
International Association for the Study of Pain ® Ketamine: Does Life Begin at 40? Pain Clinical Updates Editor-in-chief Fear and Pain Pain and Philosophy Pain from Torture (0)
Axonal degeneration in the APP / PS 1 mouse model of Alzheimer ’ s disease (2011) (0)
Preliminary evaluation of cultured embryonic rat midbrain neurons as an in vitro model of diabetic neuropathy (2006) (0)
PRG100, a novel anti-allodynic agent (2006) (0)
Inhibition of K+-evoked substance P release from slices of rat spinal cord by the novel calcium channel blockers, AM336 and AM543, relative to ziconotide (1999) (0)
Development and validation of an lc-ms/ms bioanalytical method for quantification of homocysteine (hcy) in samples of human serum (2014) (0)
Spontaneous oscillations in neuronal cytosolic free Ca2+ ([Ca2+]cyt ) in rat cultured embryonic hippocampal neurons maintained in serum-free neurobasal medium (2000) (0)
Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process (2021) (0)
Compositions comprising nitric oxide donors and opioid analgesics (2003) (0)
Faculty Opinions recommendation of Doxapram stimulates respiratory activity through distinct activation of neurons in the nucleus hypoglossus and the pre-Bötzinger complex. (2020) (0)
A fresh approach to neuropathic pain management: From the animal model to the patient (2003) (0)
Original Small Molecule Angiotensin II Type 2 Receptor (AT 2 R) Antagonists as Novel Analgesics for Neuropathic Pain: Comparative Pharmacokinetics, Radioligand Binding, and Efﬁcacy in Rats (2013) (0)
Faculty Opinions recommendation of Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications. (0)
Antinociceptive efficacy of intrathecal AM336 for the relief of adjuvant-induced chronic inflammatory pain in the rat hindpaw (2000) (0)
Tissue temperature as a function of heat exposure time using the tail flick latency test for both the dorsal and ventral surfaces of the rat tail (1999) (0)
Retrospective drug utilisation evaluation of gabapentin for the treatment of neuropathic pain by the Multidiscplinary Pain Centre, Royal Brisbane and Women's Hospital (2006) (0)
Heterodimeric opioid receptors: Novel targets for a new generation of opioid analgesics. (2001) (0)
Incomplete antinociceptive cross-tolerance between oxycodone and morphine in the rat (1999) (0)
DEVELOPMENT OF XEN2174: NON-CLINICAL STUDIES AND AN OPEN-LABEL I/IIa STUDY OF INTRATHECAL USE IN ONCOLOGY PATIENTS WITH MODERATE TO SEVERE PAIN (2009) (0)
Oxycodone, but not morphine, is efficacious for the relief of tactile allodynia in diabetic rats at three and six months after the induction of diabetes with streptozotocin (2002) (0)
Faculty Opinions recommendation of Esketamine counters opioid-induced respiratory depression. (2020) (0)
Pharmacological studies to define the mechanism mediating the neuro-excitatory side-effects of morphine-3-glucuronide (M3G). (2001) (0)
Follow-up audit of analgesic prescribing and use at the Multidisciplinary Pain Centre at Royal Brisbane Hospital: Temporal changes in anticonvulsant prescribing from 1999 to 2000 (2001) (0)
Efficacy of Pregabalin And Oxycodone in patients with post-herpetic neuralgia or painful diabetic neuropathy (2008) (0)
Communications Manager Animal Models Pain and Genetics Neuropathic Pain Fibromyalgia Syndrome : Definition (2010) (0)
Treating post-herpetic neuralgia or painful diabetic neuropathy with a combination of pregabalin and oxycodone: A randomized controlled trial (2008) (0)
Faculty Opinions recommendation of A brain-targeted ampakine compound protects against opioid-induced respiratory depression. (2020) (0)
Mechanistic insight into the anti-allodynic effects of PRG150 (2008) (0)
Opioids and NMDA receptors: Neuro-excitation and abnormal pain behaviours (2004) (0)
Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract (2004) (0)
Analgesic Efﬁcacy and Mode of Action of a Selective Small Molecule Angiotensin II Type 2 Receptor Antagonist in a Rat Model of Prostate Cancer-Induced Bone Pain (2014) (0)
Quantification of morphine, oxycodone, morphine-3-glucuronide and noroxycodone in rat serum by high performance liquid chromatography (HPLC-electrospray mass spectrometry (EMS) (2003) (0)
Influence of oestradiol pretreatment of adult male rats on levels of antinociception evoked by chronically infused intravenous morphine (2001) (0)
Does Cefazolin Prophylaxis During Elective Bariatric Caesarean Section Achieve Therapeutic Concentrations in Plasma and Interstitial Fluid (2018) (0)
Combining opioids - Preclinical and clinical studies (2006) (0)
Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data (2018) (0)
The NLRP3 inflammasome: role in the pathobiology of chronic pain. (2023) (0)
Assessment of fucoidin efficacy in Ab-peptide induced Alzheimer's disease model (2005) (0)
Extracoproreal membrane oxygenation (ECMO) has more profound influence on ciprofloxacin pharmacokinetics in critically ill sheep when compared with healthy sheep (2013) (0)
Update on opioids receptors (2006) (0)
Oxycodone: A dose ranging pharmacodynamic study in dogs (2004) (0)
The APS/APRA PhD Scholarship Scheme: Basic and clinical science research targeted to improving patient outcomes (2007) (0)
Comparative profiles of the antinociceptive and constipating effects of single intracerebroventricular (i.c.v.) bolus doses of morphine and oxycodone in rats (2008) (0)
Comments on Goucke et al., Pain, 56 (1994) 145–149 (1994) (0)
Heterodimeric opioid receptors: Implications for practice? (2001) (0)
Systematic investigation of sex differences in the antinociceptive effects of morphine in the rat (1999) (0)
Chronic administration of dietary L-Arginine reverses opioid hyposensitivity for the relief of tactile allodynia in a rat model of diabetic neuropathy (2005) (0)
Mechanisms of Chronic Pain in Functional Abdominal Pain (2013) (0)
Faculty Opinions recommendation of AMPAkines and morphine provide complementary analgesia. (2020) (0)
Faculty Opinions recommendation of Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of non-evoked ongoing pain. (2020) (0)
Faculty Opinions recommendation of Doxapram treatment and diaphragmatic activity in preterm infants. (2020) (0)
Electrolyte removal from artificial CSF by HPLC to restore ESI-MS/MS signal intensity in quantification of morphine and its glucuronide metabolites (2002) (0)
CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats. (2023) (0)
Document Specialist Fear and Pain Pain in Women Pain from torture (0)
Determination of morphine, oxycodone, morphine-3-glucuronide, & noroxycodone concentrations in rat serum by liquid chromatography (LC) - electrospray mass spectrometry (EMS) (2004) (0)
Comments on Gong et al., PAIN, 48 (1992) 249–255 (1992) (0)
Analgesic efficacy and mode of action of small molecule Angiotensin II type 2 receptor (AT2R) antagonists for neuropathic and inflammatory pain (2014) (0)
2',3'-Dideoxycytidine-Induced Neuropathy: Comparison With Other Neuropathic Pain Models (2007) (0)
Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice (2021) (0)
Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat (2008) (0)
Pain and its treatment (2005) (0)
The neuro-excitatory effects of morphine-3-glucuronide (M3G): Studies of the possible role of non-NMDA mechanisms in cultured embryonic rat hippocampal neurones. (2001) (0)
Opioid rotation and methadone: Pharmacokinetic considerations (2004) (0)
Development of novel X-conopeptide inhibitors of the norepinephrine transporter with analgesic potential (2008) (0)
Incomplete and assymetric antinociceptive cross-tolerance between oxycodone and morphine in the rat (2000) (0)
Hydromorphone-3-glucuronide (H3G) is a more potent neuro-excitant than morphine-3-glucuronide (M3G) in the rat (1999) (0)
Supraspinally administered oxycodone has intrinsic anti-allodynic effects for the alleviation of tactile allodynia in adult male rats with streptozotocin-induced diabetes (2002) (0)
Faculty Opinions recommendation of A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia. (2020) (0)
Why different pain-killers are only effective for certain types of pain (2015) (0)
Faculty Opinions recommendation of Intravenous and Intratracheal Thyrotropin Releasing Hormone and Its Analog Taltirelin Reverse Opioid-Induced Respiratory Depression in Isoflurane Anesthetized Rats. (2020) (0)
Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process (2021) (0)
The novel compound PRG100 reverses tactile allodynia in STZ-induced diabetic rats (2006) (0)
Investigation of the anti-allodynic and anti-hyperalgesics effects of ACV1 in a rat model of neuropathic pain (2005) (0)
Neurobiology of Pain: Identification of novel targets for new pain management medications (2003) (0)
(PK)PD of the anti-allodynic effects of gabapentin and oxycodone in a neuropathic pain rodent model (2006) (0)
High-quality, cost-effective preclinical product development solutions (2009) (0)
A behavioural study assessing memory deficits in the APP/PS1 double transgenic mouse model of Alzheimer’s disease using the Morris water maze. (2010) (0)
Faculty Opinions recommendation of The impact and mechanism of a novel allosteric AMPA receptor modulator LCX001 on protection against respiratory depression in rodents. (2020) (0)
Investigation of the role of dynorphin-A in mediating morphine-3-glucuronide's neuro-excitatory effects (2002) (0)
MORPHINE MARKEDLY INCREASES MORPHINE ANTINOCICEPTION AND DELAYS DEVELOPMENT OF ANTINOCICEPTIVE TOLERANCE IN RATS 1 (2000) (0)
Mechanistic insight into the anti-allodynic effects of PRG100 (2008) (0)
Editor-in-chief Upcoming Issues Advanced Neuroimaging for the Study of Migraine Pathophysiology Metric-based Pain Care Contemporary Physical Therapy Marijuana and Pain Migraine and the Brainstem (2012) (0)
Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy (2019) (0)
Temporal changes in the potency of subcutaneous oxycodone relative to morphine for the alleviation of tactile allodynia in Dark Agouti Rats with diabetes secondary to streptozotocin injection (2001) (0)
P2.3 longitudinal investigation of the comparative anti-allodynic potencies of oxycodone and morphine in the zucker rat relative to the streptozotocin-induced diabetic rat (2004) (0)
ICV hydromorphone-3-glucuronide (H3G) elicits neuro-excitation in the rat (2000) (0)
Comment on “protective arms of the renin‐angiotensin system in neurological disease” (2013) (0)
Taking the pain out of research (2008) (0)
Possible mechanism of action for neuroprotective effect of fucoidin in A-beta-induced Alzheimer's disease model (2007) (0)
Altered Antibiotic Pharmacokinetics during Extracorporeal Membrane Oxygenation may Cause Therapeutic Failure (2012) (0)
Increased potency of single doses of subcutaneous oxycodone, but not morphine, in Dark Agouti rats with a chronic constriction injury (CCI) of the sciatic nerve relative to control rats. (2001) (0)
Preliminery investigation of the ability of oxycodone to stimulate agonist-induced internalisation of the m-opioid receptor (2001) (0)
Novel strategies in new opioid analgesic development (2008) (0)
Pharmacokinetics of some highly metabolised substances (0)
Differential potency of subcutaneous morphine and oxycodone for the relief of mechanical allodynia in dark agouti rats with a chronic constriction injury (CCI) of the sciatic nerve (2000) (0)
Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine (2000) (0)
Faculty Opinions recommendation of Breathing stimulation mediated by 5-HT1A and 5-HT3 receptors within the preBötzinger complex of the adult rabbit. (2020) (0)
Effect of insulin treatment on diabetic characteristics in the STZ-diabetic rat (2004) (0)
Establishment of a rat model of low back pain (2014) (0)
Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods (2019) (0)
Evaluation of the neurotoxic effects of morphine-3-glucuronide (M3G) in neuronal cultures. (2001) (0)
Morphine-3-glucuronide (M3G) evoked increases in [Ca2+]cyt oscillations in cultured rat embryonic hippocampal neurones (2000) (0)
Specialist dysmenorrhea Pain and Quality of life What does Pain Hurt ? Chronic Pain in Survivors of Torture (0)
Managing diabetic neuropathy (2003) (0)
Success in Navigating Hurdles to Oral Delivery of a Bioactive Peptide Complement Antagonist through Use of Nanoparticles to Increase Bioavailability and In Vivo Efficacy (2022) (0)
Effect of testosterone on the antinociceptive effects of iv and icv morphine in adult female Sprague-Dawley rats (1999) (0)
A study of the application of the Morris water maze to the establishment of a preclinical model of Alzheimer's disease in the rat (2009) (0)
Antihyperalgesic and anti-inflammatory effects of RS- & S-ketamine in freunds complete adjuvant (FCA)-induced inflammation (2005) (0)
What you and your patient need to know about opioids (2005) (0)
Electrolyte removal is essential for optimizing ESI-MS/MS signal intensity for the quantification of morphine and morphine-3-glucuronide in samples of rat brain microdialysate (2001) (0)
A randomized control trial of pregabalin and oxycodone in post herpetic neuralgia and painful diabetic neuropathy (2007) (0)
TRANSLATIONAL RESEARCH SECTION Original Research Article Insulin Implants Prevent the Temporal Development of Mechanical Allodynia and Opioid Hyposensitivity for 24-Wks in Streptozotocin (STZ)-Diabetic Wistar Rats (2016) (0)
TRANSLATIONAL RESEARCH SECTION Original Research Article Analgesic Efficacy and Mode of Action of a Selective Small Molecule Angiotensin II Type 2 Receptor Antagonist in a Rat Model of Prostate Cancer-Induced Bone Pain (2016) (0)
TRANSLATIONAL RESEARCH SECTION Original Research Article Insulin Implants Prevent the Temporal Development of Mechanical Allodynia and Opioid Hyposensitivity for 24-Wks in Streptozotocin (STZ)-Diabetic Wistar Rats (2016) (0)
Serum concentrations of metabolically-derived oxymorphone are insignificant in diabetic and non-diabetic adult male Dark Agouti rats following subcutaneous oxycodone bolus administration: Comparison with Sprague-Dawley rats (2003) (0)
Centre for Integrated Preclinical Drug Development (2019) (0)
Comparative profiles of the antinociceptive and constipating effects of single intracerebroventricular (i.c.v.) bolus doses of morphine, morphine-6-glucuronide and fentanyl in rats Kuo A, Hemstapat K, Wyse BD, Smith MT (2008) (0)
Prolonged oestradiol supplementation does not significantly alter levels of antinociception evoked by ICV morphine in adult male rats (2001) (0)
High Performance Liquid Chromatography (HPLC) determination of oxycodone in human plasma after oral, rectal and intravenous routes (1990) (0)
Investigation of temporal changes in the anti-allodynic effectiveness of chronically administered gabapentin in a rat model of neuropathic pain (2005) (0)
Faculty Opinions recommendation of Grks as key modulators of opioid receptor function. (2020) (0)
Upcoming Issues Dysmenorrhea Pancreatitis Marijuana for Pain Functional Abdominal Pain (2013) (0)
Elucidation of the mechanism underlying the neuro-excitatory effects of morphine-3-glucoronide (M3G): Studies in rat embryonic hippocampal neurones (2000) (0)
The pro-allodynic effects of morphine-3-glucuronide (M3G) appear to be opioid-receptor mediated (2004) (0)
In vivo investigation of the effects of intracerebroventricular (ICV) morphine-3-glucuronide (M3G) on von frey paw withdrawal thresholds in rats (2002) (0)
The pro-allodynic effects of morphine-3-glucuronide (M3G) in the rat (2004) (0)
ArticleAssessment of the Anti-Allodynic and Anti-Hyperalgesic Efficacy of a Glycine Transporter (2021) (0)
Antinociceptive potencies and motor effects of the calcium channel blockers, AM336 and ziconotide, following intrathecal administration to FCA-treated rats (1999) (0)
Multitargeted Opioid Ligand Discovery as a Strategy to Retain Analgesia and Reduce Opioid-Related Adverse Effects. (2023) (0)
P/Q and L-type calcium channel blockers abolish morphine-3-glucuronide (M3G)-induced indirect activation of the NMDA receptor (2002) (0)
Faculty Opinions recommendation of Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat. (2020) (0)
Nonconventional Opioid Receptors in Human and Rat Lung (1992) (0)
Assessment of fucoidin efficacy in a beta-peptide induced in Alzheimer's disease model (2006) (0)
Acid-sensing ion channel modulator, APETx2, has a more complex phamacological and therapeutic profile than previously reported (2019) (0)
Intrathecal XEN2174 produces significant anti-allodynia in morphine-tolerant rats using the CCI-model of persistent neuropathic pain (2005) (0)
Co-administration of pregabalin and oxycodone for the treatment of neuropathic pain: A randomized double-blind, placebo-controlled, parallel-group study (2007) (0)
Foot orthoses make for Happi kneecaps! of adolescents with patellofemoral pain: a mixed methods design including randomised feasibility trial (2021) (0)
Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials (2022) (0)

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