Marek Mlodzik
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Marek Mlodzikbiology Degrees
Biology
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#2710
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Developmental Biology
#43
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#47
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Molecular Biology
#294
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#299
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Biology
Marek Mlodzik's Degrees
- PhD Biology University of Warsaw
- Masters Biotechnology University of Warsaw
- Bachelors Biotechnology University of Warsaw
Why Is Marek Mlodzik Influential?
(Suggest an Edit or Addition)According to Wikipedia, Marek Mlodzik is the Chair of the Department of Molecular, Cell and Developmental Biology and also holds professorships in Oncological Sciences and Ophthalmology at the Mount Sinai School of Medicine in New York City. Prior to this he was a Group Leader at EMBL Heidelberg. In 1997, Mlodzik was elected as a member of the European Molecular Biology Organization.
Marek Mlodzik's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling (1998) (797)
- Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways (2005) (757)
- The role of RhoA in tissue polarity and Frizzled signalling (1997) (594)
- Planar cell polarity signaling: from fly development to human disease. (2008) (569)
- Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility (2007) (546)
- Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. (2003) (517)
- The drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates (1990) (474)
- Planar cell polarity signalling couples cell division and morphogenesis during neurulation (2006) (396)
- Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. (1999) (359)
- Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? (2002) (357)
- Planar cell polarization: an emerging model points in the right direction. (2005) (333)
- Wnt-Frizzled/planar cell polarity signaling: cellular orientation by facing the wind (Wnt). (2015) (276)
- Dishevelled: at the crossroads of divergent intracellular signaling pathways (1999) (276)
- Expression of the caudal gene in the germ line of Drosophila: Formation of an RNA and protein gradient during early embryogenesis (1987) (267)
- Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous. (1990) (267)
- Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila. (1990) (261)
- The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. (2001) (252)
- The planar polarity gene strabismus regulates convergent extension movements in Xenopus (2002) (245)
- Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. (1996) (242)
- Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling (2003) (240)
- Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye (1999) (227)
- Isolation of caudal, a Drosophila homeo box‐containing gene with maternal expression, whose transcripts form a concentration gradient at the pre‐blastoderm stage (1985) (217)
- Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding (2005) (209)
- Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. (2000) (200)
- Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye (2000) (194)
- Nomenclature: Vertebrate Mediators of TGFβ Family Signals (1996) (189)
- Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent. (2000) (181)
- The Apical Determinants aPKC and dPatj Regulate Frizzled-Dependent Planar Cell Polarity in the Drosophila Eye (2005) (177)
- Planar polarity in the Drosophila eye: a multifaceted view of signaling specificity and cross‐talk (1999) (174)
- Cooperative control of Drosophila immune responses by the JNK and NF‐κB signaling pathways (2006) (173)
- Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes (2004) (172)
- muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins. (1997) (164)
- Six class homeobox genes in Drosophila belong to three distinct families and are involved in head development (1999) (164)
- Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila (2013) (161)
- The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling. (2008) (159)
- The muscleblind gene participates in the organization of Z-bands and epidermal attachments of Drosophila muscles and is regulated by Dmef2. (1998) (158)
- Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development (2009) (153)
- Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. (1997) (153)
- Coordinating proliferation and tissue specification to promote regional identity in the Drosophila head. (2003) (153)
- The Drosophila formin DAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeleton (2006) (146)
- A quest for the mechanism regulating global planar cell polarity of tissues. (2009) (137)
- Regulation of Lethal giant larvae by Dishevelled (2005) (133)
- Signaling specificity by Frizzled receptors in Drosophila. (2000) (130)
- Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants (1997) (125)
- The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye. (2002) (122)
- Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A (1995) (120)
- Secreted Fringe-like Signaling Molecules May Be Glycosyltransferases (1997) (117)
- LZTR1 is a regulator of RAS ubiquitination and signaling (2018) (116)
- The Drosophila STE20‐like kinase Misshapen is required downstream of the Frizzled receptor in planar polarity signaling (1999) (113)
- JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye (1995) (113)
- Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation. (1994) (105)
- Subcellular Localization of Frizzled Receptors, Mediated by Their Cytoplasmic Tails, Regulates Signaling Pathway Specificity (2004) (104)
- From instruction to output: Wnt/PCP signaling in development and cancer. (2018) (104)
- Enhancer Trap Method in Drosophila: Its Application to Neurobiology (1992) (103)
- TGFβ Activated Kinase-1: New Insights into the Diverse Roles of TAK1 in Development and Immunity (2006) (103)
- Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization (2009) (100)
- Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development. (1997) (96)
- Drosophila Jun mediates Ras-dependent photoreceptor determination (1994) (91)
- Ectopic expression of seven-up causes cell fate changes during ommatidial assembly. (1993) (89)
- Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development. (2009) (89)
- Planar cell polarity signaling: coordination of cellular orientation across tissues (2012) (87)
- The role of yan in mediating the choice between cell division and differentiation. (1995) (85)
- Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization (2009) (85)
- The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors. (2009) (83)
- Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6 (2003) (79)
- CKIɛ/discs overgrown Promotes Both Wnt-Fz/β-Catenin and Fz/PCP Signaling in Drosophila (2006) (79)
- Effects of ectopic expression of caudal during Drosophila development. (1990) (79)
- Functional conservation of vertebrate seven‐up related genes in neurogenesis and eye development. (1993) (79)
- Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia‐complex. (1988) (78)
- Planar cell polarity signaling: a common mechanism for cellular polarization. (2006) (78)
- Cell-fate determination in the developing Drosophila eye: role of the rough gene. (1991) (77)
- Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. (2006) (76)
- PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress (2018) (76)
- Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye. (2005) (75)
- Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. (2001) (75)
- Nomenclature: vertebrate mediators of TGFbeta family signals. (1996) (73)
- Diversin regulates heart formation and gastrulation movements in development (2006) (72)
- distal antenna and distal antenna related encode nuclear proteins containing pipsqueak motifs involved in antenna development in Drosophila (2003) (71)
- Cooperative activities of Drosophila DE-Cadherin and DN-Cadherin regulate the cell motility process of ommatidial rotation (2006) (70)
- The role of the Drosophila TAK homologue dTAK during development (2001) (69)
- Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. (2003) (67)
- β-Catenin-Independent Activation of TCF1/LEF1 in Human Hematopoietic Tumor Cells through Interaction with ATF2 Transcription Factors (2013) (64)
- Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling. (2000) (63)
- The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies. (2016) (62)
- CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. (2006) (60)
- Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc. (1997) (59)
- Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation. (1996) (58)
- Faculty Opinions recommendation of Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system. (2005) (57)
- Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium (2011) (56)
- Confrontation of scabrous expressing and non-expressing cells is essential for normal ommatidial spacing in the Drosophila eye. (1994) (55)
- The Drosophila orphan nuclear receptor seven-up requires the Ras pathway for its function in photoreceptor determination. (1995) (51)
- Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking (2012) (49)
- Hierarchy of the genetic interactions that specify the anteroposterior segmentation pattern of the Drosophila embryo as monitored by caudal protein expression (1987) (49)
- Spalt transcription factors are required for R3/R4 specification and establishment of planar cell polarity in the Drosophila eye (2004) (49)
- Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye. (2008) (48)
- Selector and signalling molecules cooperate in organ patterning (2002) (48)
- Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin–β-catenin (2011) (46)
- Intertissue Mechanical Stress Affects Frizzled-Mediated Planar Cell Polarity in the Drosophila Notum Epidermis (2011) (46)
- The Drosophila Jak kinase hopscotch is required for multiple developmental processes in the eye. (1999) (46)
- Centrosomal localization of Diversin and its relevance to Wnt signaling (2009) (44)
- Functional dissection of phosphorylation of Disheveled in Drosophila. (2011) (43)
- pipsqueak encodes a novel nuclear protein required downstream of seven‐up for the development of photoreceptors R3 and R4. (1995) (42)
- Mechanisms of planar cell polarity establishment in Drosophila (2014) (42)
- The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development (2000) (42)
- Identification of the Drosophila progenitor of mammalian Krüppel-like factors 6 and 7 and a determinant of fly development. (2003) (40)
- Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation. (2010) (40)
- Wnk kinases are positive regulators of canonical Wnt/β‐catenin signalling (2013) (38)
- Frizzled/PCP-dependent asymmetric neuralized expression determines R3/R4 fates in the Drosophila eye. (2006) (38)
- Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions. (1995) (37)
- A novel vertebrate svp-related nuclear receptor is expressed as a step gradient in developing rhombomeres and is affected by retinoic acid (1995) (34)
- Linking cell-fate specification to planar polarity: determination of the R3/R4 photoreceptors is a prerequisite for the interpretation of the Frizzled mediated polarity signal (1998) (34)
- Disabled is a bona fide component of the Abl signaling network (2010) (34)
- The clathrin adaptor AP-1 complex and Arf1 regulate planar cell polarity in vivo (2015) (33)
- Frizzled–Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila (2008) (33)
- Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development. (1999) (32)
- Frizzled-Induced Van Gogh Phosphorylation by CK1ε Promotes Asymmetric Localization of Core PCP Factors in Drosophila. (2016) (32)
- Spiny legs and prickled bodies: new insights and complexities in planar polarity establishment. (2000) (31)
- Analysis of the role of the Rac/Cdc42 GTPases during planar cell polarity generation in Drosophila. (2007) (31)
- Drosophila Abelson kinase mediates cell invasion and proliferation via two distinct MAPK pathways (2010) (30)
- Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling (2016) (29)
- distal antenna and distal antenna-related function in the retinal determination network during eye development in Drosophila. (2007) (29)
- The Drosophila selectin furrowed mediates intercellular planar cell polarity interactions via frizzled stabilization. (2013) (29)
- The regulation of hedgehog and decapentaplegic during Drosophila eye imaginal disc development (1996) (28)
- Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization (2012) (27)
- Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity. (2016) (26)
- The presumptive R7 cell of the developing Drosophila eye receives positional information independent of sevenless, boss and sina (1992) (26)
- The influence on the blastoderm fate map of maternal-effect genes that affect the antero-posterior pattern in Drosophila (1987) (25)
- Drosophila TFIIA-S is up-regulated and required during Ras-mediated photoreceptor determination. (1996) (25)
- Functional analysis of the fibrinogen-related scabrous gene from Drosophila melanogaster identifies potential effector and stimulatory protein domains. (1998) (24)
- Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages. (2012) (23)
- The deubiquitination enzyme Fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development (1997) (23)
- Microscopic analysis of the adult Drosophila retina using semithin plastic sections. (2008) (20)
- Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling (2018) (17)
- Components of Intraflagellar Transport Complex A Function Independently of the Cilium to Regulate Canonical Wnt Signaling in Drosophila. (2015) (17)
- The Drosophila GIPC Homologue Can Modulate Myosin Based Processes and Planar Cell Polarity but Is Not Essential for Development (2010) (16)
- APC/CFzr/Cdh1-Dependent Regulation of Planar Cell Polarity Establishment via Nek2 Kinase Acting on Dishevelled. (2017) (15)
- Novel Regulators of Planar Cell Polarity: A Genetic Analysis in Drosophila (2012) (13)
- Self-modulation of Notch signaling during ommatidial development via the Roughened eye transcriptional repressor (2008) (12)
- Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila (2020) (12)
- Establishment of the Muscle–Tendon Junction During Thorax Morphogenesis in Drosophila Requires the Rho-Kinase (2016) (11)
- Wnt-frizzled planar cell polarity signaling in the regulation of cell motility. (2022) (11)
- Wnk kinases are positive regulators of canonical Wnt/β‐catenin signalling (2013) (11)
- A conserved signaling cassette regulates hair patterning from Drosophila to man. (2004) (11)
- Planar Polarity: Converting a Morphogen Gradient into Cellular Polarity (2015) (10)
- Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation. (2013) (9)
- Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation (2021) (9)
- Planar cell polarization during development (2005) (8)
- Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model. (2018) (8)
- Wnt/PCP Instructions for Cilia in Left-Right Asymmetry. (2017) (8)
- A new allele uncovers the role of echinus in the control of ommatidial rotation in the Drosophila eye (2007) (8)
- A New Spin on Planar Cell Polarity (2010) (7)
- Faculty Opinions recommendation of Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. (2014) (7)
- Luna, a Drosophila KLF6/KLF7, Is Maternally Required for Synchronized Nuclear and Centrosome Cycles in the Preblastoderm Embryo (2014) (6)
- A GAP in convergent extension scores PAR. (2006) (6)
- Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix (2019) (6)
- Planar cell polarity: moving from single cells to tissue-scale biology (2020) (6)
- Faculty Opinions recommendation of Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. (2014) (5)
- six-banded, a Novel Drosophila Gene, Is Expressed in 6 Segmental Stripes during Embryonic Development and in the Eye Imaginal Disc (1997) (5)
- Faculty Opinions recommendation of Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. (2014) (5)
- A Novel Frizzled-Based Screening Tool Identifies Genetic Modifiers of Planar Cell Polarity in Drosophila Wings (2016) (5)
- Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos (2019) (5)
- WNKs in Wnt/β-catenin signaling (2013) (4)
- Planar cell polarity in the Drosophila eye: Cell fate and organization (2005) (4)
- Planar cell polarity: moving from single cells to tissue-scale biology. (2020) (4)
- Tissue polarity in the retina. (2002) (4)
- Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment (2018) (4)
- Phosphatidic acid increases Notch signalling by affecting Sanpodo trafficking during Drosophila sensory organ development (2020) (3)
- AKAP200 promotes Notch stability by protecting it from Cbl/lysosome-mediated degradation in Drosophila melanogaster (2018) (3)
- Sec 61 β , a subunit of the protein translocation channel , is required during Drosophila development (1999) (2)
- Modified vectors for the two-step directional cloning of inverted repeats for RNA interference in Drosophila. (2008) (2)
- Different strategies by distinct Wnt-signaling pathways in activating a nuclear transcriptional response. (2022) (2)
- Erratum: Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling (EMBO Reports (2013) 14 (718-725) DOI:10.1038/embor.2013.88) (2013) (2)
- PCYT 1 A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress Graphical (2018) (1)
- Drosophila Furrowed/Selectin is a homophilic cell adhesion molecule stabilizing Frizzled and intercellular interactions during PCP establishment (2014) (1)
- Ubiquitin Connects with Planar Cell Polarity (2009) (1)
- Par3/Bazooka promotes Notch pathway target gene activation (2022) (1)
- Regulation of Numb during planar cell polarity establishment in the Drosophila eye (2019) (1)
- Faculty Opinions recommendation of Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt. (2002) (1)
- Walter J Gehring (1939-2014). (2014) (1)
- Notch-dependent Abl signaling regulates cell motility during ommatidial rotation in Drosophila (2021) (1)
- Fu ARY Drosophila orphan nuclear receptor Seven-up s function in photoreceptor determination (0)
- The beauty of seeing the real thing: BMP heterodimer detection in vivo reveals dimer composition and activity. (2023) (0)
- A new piece to the unsolved planar cell polarity puzzle. (2011) (0)
- Abstract A08: Genetic drug resistance screen identifies LZTR1 as regulator of RAS ubiquitination and signaling (2020) (0)
- Blitzer et al-pnas-suppl 2011 (2013) (0)
- Disabled is a bona fide component of the Abl signaling network (2010) (0)
- Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling (2018) (0)
- A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled (2022) (0)
- Supplementary material from "Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix" (2019) (0)
- Faculty Opinions recommendation of Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins. (2014) (0)
- The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization (2022) (0)
- Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos (2019) (0)
- Faculty Opinions recommendation of Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit. (2014) (0)
- Faculty Opinions recommendation of Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity. (2014) (0)
- Author response: Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila (2020) (0)
- Walter J. Gehring (1939-2014). (2014) (0)
- Faculty Opinions recommendation of Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. (2014) (0)
- Faculty Opinions recommendation of Mathematical modeling of planar cell polarity to understand domineering nonautonomy. (2005) (0)
- Distal Antenna and Distal Antenna–related, Two Nuclear Proteins Containing Pipsqueak Motifs, Induce Ectopic Eyes and Are Required for Eye Development in Drosophila melanogaster (2005) (0)
- Connecting up the pathways in Drosophila development. (1997) (0)
- Faculty Opinions recommendation of Frizzled6 controls hair patterning in mice. (2004) (0)
- When cells get in the flow (2022) (0)
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Marek Mlodzik is affiliated with the following schools:
