Margaret Ackerman
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American engineer
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Margaret Ackermanengineering Degrees
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Applied Physics
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Engineering
Why Is Margaret Ackerman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Margaret Ackerman is an American engineer who is a professor at Dartmouth College. Ackerman develops high throughput tools to evaluate the antibody response in disease states. She oversees biological and chemical engineering in the Thayer School of Engineering.
Margaret Ackerman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines (2014) (349)
- A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples. (2010) (332)
- Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity. (2013) (291)
- Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology (2015) (286)
- Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys (2015) (275)
- Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control (2016) (203)
- Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition (2016) (182)
- High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples. (2012) (169)
- Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles (2017) (123)
- Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge (2017) (111)
- Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV (2018) (108)
- Identification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function (2014) (98)
- Protein-Protein Fusion Catalyzed by Sortase A (2011) (97)
- A modular IgG-scFv bispecific antibody topology. (2010) (95)
- Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids (2008) (90)
- A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis. (2015) (89)
- An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. (2014) (88)
- Enhanced Phagocytic Activity of HIV-Specific Antibodies Correlates with Natural Production of Immunoglobulins with Skewed Affinity for FcγR2a and FcγR2b (2013) (88)
- Stability and CDR composition biases enrich binder functionality landscapes. (2010) (79)
- Highly avid magnetic bead capture: An efficient selection method for de novo protein engineering utilizing yeast surface display (2009) (79)
- Fc Receptor-Mediated Phagocytosis in Tissues as a Potent Mechanism for Preventive and Therapeutic HIV Vaccine Strategies (2016) (79)
- Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals. (2011) (75)
- Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs. (2017) (74)
- Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination (2020) (70)
- Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women (2019) (69)
- A33 antigen displays persistent surface expression (2008) (69)
- Emerging concepts on the role of innate immunity in the prevention and control of HIV infection. (2012) (67)
- Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement (2018) (67)
- Systems serology for evaluation of HIV vaccine trials (2017) (65)
- Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies (2014) (64)
- Highly parallel characterization of IgG Fc binding interactions (2014) (60)
- Distinct Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals (2021) (55)
- HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies (2018) (55)
- Dendritic Cells from the Human Female Reproductive Tract Rapidly Capture and respond to HIV (2016) (55)
- Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function (2019) (52)
- IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody (2019) (50)
- Antibody humanization by structure-based computational protein design (2015) (49)
- Live attenuated and inactivated influenza vaccines in children. (2015) (49)
- Vaccine-induced mucosal immunity to poliovirus: analysis of cohorts from an open-label, randomised controlled trial in Latin American infants (2016) (46)
- Independent evolution of Fc‐ and Fab‐mediated HIV‐1‐specific antiviral antibody activity following acute infection (2014) (45)
- Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects (2016) (44)
- Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody (2020) (43)
- Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma (2021) (42)
- Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study (2019) (42)
- Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination (2022) (42)
- Divergent Antibody Subclass and Specificity Profiles but Not Protective HLA-B Alleles Are Associated with Variable Antibody Effector Function among HIV-1 Controllers (2013) (42)
- Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality (2020) (40)
- Intestinal immunity is a determinant of clearance of poliovirus after oral vaccination. (2014) (39)
- Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies (2020) (39)
- Opportunities to exploit non-neutralizing HIV-specific antibody activity. (2013) (38)
- Machine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees (2015) (37)
- IgG Binding Characteristics of Rhesus Macaque FcγR (2016) (36)
- The role of Fc receptors in HIV prevention and therapy (2015) (36)
- Antibody‐mediated complement activation in pathology and protection (2020) (35)
- Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial (2017) (35)
- Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine (2016) (34)
- Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity (2019) (34)
- Evidence that CD32a does not mark the HIV-1 latent reservoir (2018) (34)
- Genetically Engineered Alginate Lyase-PEG Conjugates Exhibit Enhanced Catalytic Function and Reduced Immunoreactivity (2011) (33)
- High‐resolution definition of humoral immune response correlates of effective immunity against HIV (2018) (33)
- Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells (2015) (33)
- Computationally-driven identification of antibody epitopes (2017) (32)
- Knowns and Unknowns of Assaying Antibody-Dependent Cell-Mediated Cytotoxicity Against HIV-1 (2019) (30)
- Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV (2018) (30)
- Vaccine design: emerging concepts and renewed optimism. (2013) (30)
- Biophysical and Functional Characterization of Rhesus Macaque IgG Subclasses (2016) (29)
- Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge (2020) (29)
- Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG? (2018) (28)
- SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy (2020) (28)
- Determining the phagocytic activity of clinical antibody samples. (2011) (28)
- Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge. (2020) (27)
- Intestinal Immune Responses to Type 2 Oral Polio Vaccine (OPV) Challenge in Infants Previously Immunized With Bivalent OPV and Either High-Dose or Standard Inactivated Polio Vaccine (2018) (26)
- Poor antibody response to BioNTech/Pfizer COVID-19 vaccination in SARS-CoV-2 naïve residents of nursing homes (2021) (22)
- Analysis of Complement-Mediated Lysis of Simian Immunodeficiency Virus (SIV) and SIV-Infected Cells Reveals Sex Differences in Vaccine-Induced Immune Responses in Rhesus Macaques (2018) (22)
- Increasing the Clinical Potential and Applications of Anti-HIV Antibodies (2017) (21)
- Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality. (2021) (21)
- Prospects for engineering HIV-specific antibodies for enhanced effector function and half-life (2015) (21)
- Mapping the journey to an HIV vaccine. (2013) (20)
- Microscale purification of antigen-specific antibodies. (2015) (19)
- Coming together at the hinges: Therapeutic prospects of IgG3 (2021) (19)
- Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site (2018) (19)
- IgG Fc variant cross-reactivity between human and rhesus macaque FcγRs (2017) (19)
- λ Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein Antibodies. (2016) (18)
- Engineering broadly neutralizing antibodies for HIV prevention and therapy. (2016) (16)
- High-throughput characterization of the functional impact of IgG Fc glycan aberrancy in juvenile idiopathic arthritis (2017) (16)
- IgG Fc glycosylation as an axis of humoral immunity in childhood. (2020) (15)
- Mining for humoral correlates of HIV control and latent reservoir size (2020) (15)
- Mucosal immunity to poliovirus (2021) (14)
- Antibody Fab‐Fc properties outperform titer in predictive models of SIV vaccine‐induced protection (2019) (14)
- Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals (2020) (14)
- Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities (2021) (14)
- HIV-antibody complexes enhance production of type I interferon by plasmacytoid dendritic cells (2017) (14)
- Chimeric antigen receptors with human scFvs preferentially induce T cell anti-tumor activity against tumors with high B7H6 expression (2018) (14)
- A multiplexed assay to detect antimicrobial peptides in biological fluids and cell secretions. (2013) (13)
- Separation of nonfucosylated antibodies with immobilized FcγRIII receptors (2013) (13)
- Boosting of Cross-Reactive Antibodies to Endemic Coronaviruses by SARS-CoV-2 Infection but not Vaccination with Stabilized Spike (2021) (12)
- Going native: Direct high throughput screening of secreted full-length IgG antibodies against cell membrane proteins (2017) (12)
- Development of unique cytotoxic chimeric antigen receptors based on human scFv targeting B7H6 (2017) (12)
- Systems serology for decoding infection and vaccine-induced antibody responses to HIV-1. (2019) (11)
- A Randomized Phase 4 Study of Immunogenicity and Safety After Monovalent Oral Type 2 Sabin Poliovirus Vaccine Challenge in Children Vaccinated with Inactivated Poliovirus Vaccine in Lithuania (2020) (10)
- Intestinal antibody responses to a live oral poliovirus vaccine challenge among adults previously immunized with inactivated polio vaccine in Sweden (2019) (10)
- Directed Evolution of a Yeast-Displayed HIV-1 SOSIP gp140 Spike Protein toward Improved Expression and Affinity for Conformational Antibodies (2015) (10)
- Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities (2022) (10)
- IgG3 collaborates with IgG1 and IgA to recruit effector function in RV144 vaccinees (2020) (9)
- Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis (2022) (8)
- RV144 HIV-1 vaccination impacts post-infection antibody responses (2020) (8)
- Mucosal Immunity: The Forgotten Arm of the Immune System. (2019) (8)
- Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors (2021) (7)
- Intestinal Immunity to Poliovirus Following Sequential Trivalent Inactivated Polio Vaccine/Bivalent Oral Polio Vaccine and Trivalent Inactivated Polio Vaccine–only Immunization Schedules: Analysis of an Open-label, Randomized, Controlled Trial in Chilean Infants (2018) (7)
- Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs (2020) (7)
- Delayed fractional dosing with RTS,S/AS01 improves humoral immunity to malaria via a balance of polyfunctional NANP6- and Pf16-specific antibodies. (2021) (7)
- Enrichment of high affinity subclasses and glycoforms from serum‐derived IgG using FcγRs as affinity ligands (2018) (7)
- Longitudinal Systemic and Mucosal Immune Responses to SARS-CoV-2 Infection (2022) (6)
- Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation (2022) (6)
- Towards conformational fidelity of a quaternary HIV-1 epitope: computational design and directed evolution of a minimal V1V2 antigen (2018) (6)
- Tracking the Trajectory of Functional Humoral Immune Responses Following Acute HIV Infection (2020) (6)
- Protein-based, but not viral vector alone, HIV vaccine boosting drives an IgG1-biased polyfunctional humoral immune response. (2020) (6)
- Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques (2021) (6)
- Recent insights into Fc-mediated effector responses to HIV-1. (2020) (5)
- Polyfunctional Tier 2–Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor (2021) (5)
- Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells (2021) (5)
- Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features (2021) (5)
- Machine Learning Methods Enable Predictive Modeling of Antibody Feature : Function Relationships in RV 144 Vaccinees (2015) (5)
- Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity (2020) (4)
- Rationalizing Random Walks: Replicating Protective Antibody Trajectories. (2021) (4)
- Exploiting bias in a non-immune human antibody library to predict antigenicity. (2011) (4)
- Antibody Attributes that Predict the Neutralization and Effector Function of Polyclonal Responses to SARS-CoV-2 (2021) (4)
- Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike (2022) (4)
- Implementation of a three-tiered approach to identify and characterize anti-drug antibodies raised against HIV-specific broadly neutralizing antibodies (2020) (4)
- Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30 (2021) (3)
- Incorporating the Cluster A and V1V2 Targets into a Minimal Structural Unit of the HIV-1 Envelope to Elicit a Cross-Clade Response with Potent Fc-Effector Functions (2021) (3)
- Intestinal Antibody Responses to 2 Novel Live Attenuated Type 2 Oral Poliovirus Vaccines in Healthy Adults in Belgium (2020) (3)
- CD32 does not mark the HIV-1/SIV latent reservoir (2017) (3)
- Immunoprofiling Correlates of Protection Against SHIV Infection in Adjuvanted HIV-1 Pox-Protein Vaccinated Rhesus Macaques (2021) (3)
- Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized mice (2022) (2)
- Humoral and cellular immune correlates of protection against COVID-19 in kidney transplant recipients (2022) (2)
- What mAbs tell us about shapes: multiple roads lead to Rome. (2013) (2)
- SARS-CoV-2 mRNA vaccination elicits broad and potent Fc effector functions to VOCs in vulnerable populations (2022) (2)
- Diverse contributions of avidity to the broad neutralization of Dengue virus by antibodies targeting the E dimer epitope. (2021) (2)
- Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity (2021) (2)
- Maternal determinants of infant immunity: Implications for effective immunization and maternal-child health. (2020) (2)
- Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity (2022) (2)
- Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 prime-boost vaccination (2021) (2)
- Longitudinal antibody responses in people who inject drugs infected with similar HIV strains. (2020) (2)
- Maternally transferred monoclonal antibodies protect neonatal mice from herpes simplex virus-induced mortality and morbidity (2022) (2)
- Abstracts of the 8th HIV Persistence during Therapy Workshop (2017) (1)
- Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV (2018) (1)
- HIV-associated alterations of the biophysical features of maternal antibodies correlate with their reduced transfer across the placenta. (2022) (1)
- Combinatorial resurfacing of Dengue envelope protein domain III antigens selectively ablates epitopes associated with serotype-specific or infection-enhancing antibody responses. (2020) (1)
- Distinct HIV-Specific Antibody Fc-Profiles in RV144 and VAX003 Vaccinees (2013) (1)
- Glycosylation of Antigen-Specific Antibodies: Perspectives on Immunoglobulin G Glycosylation in Vaccination and Immunotherapy. (2021) (1)
- Author response: Computationally-driven identification of antibody epitopes (2017) (1)
- Vector induced skewing of antibody Fc-effector functions (2012) (1)
- Publisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir (2018) (1)
- Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses (2022) (1)
- Correction: RV144 HIV-1 vaccination impacts post-infection antibody responses (2021) (1)
- Antibody attributes that predict the neutralization and effector function of polyclonal responses to SARS-CoV-2 (2022) (1)
- Vaccine boosts: balancing response magnitude and character. (2020) (1)
- Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques (2022) (1)
- Plotkin Lecture in Vaccinology (2019) (1)
- Cooperation Between Systemic and Mucosal Antibodies Induced by Virosomal Vaccines Targeting HIV-1 Env: Protection of Indian Rhesus Macaques Against Low-Dose Intravaginal SHIV Challenges (2022) (1)
- The Crossroads of Glycoscience, Infection, and Immunology (2021) (1)
- Vaccine-induced mucosal immunity from IPV-BOPV and IPV-only immunization schedules: analysis of an open-label, randomized controlled trial in chilean infants (2017) (0)
- Material for Adjuvant dependent innate and adaptive immune signatures of risk of SIVmac 251 acquisition (2016) (0)
- Monoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections (2022) (0)
- Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates (2023) (0)
- Correction: Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition (2016) (0)
- This information is current as HIV-1 Envelope by GagPol-Specific Th Cells Enhancing the Quality of Antibodies to Nabi (2015) (0)
- neutralizing antibodies for HIV prevention and therapy ☆ O F (2016) (0)
- Passive infusion of Fc-modified neutralizing antibodies does not affect the dynamics of plasma virus decay in SHIV-infected macaques (2019) (0)
- Younger Children Develop Higher Effector Antibody Responses to SARS-CoV-2 Infection (2022) (0)
- Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s (2022) (0)
- G-104 Breaking the species barrier: IgG subclasses in man and macaques (2016) (0)
- Biotinylation Turnover Assay of the A33 Antigen (2007) (0)
- Kinetics of gp41-specific antibody titers and contribution of Fc mediated gp41 specific antibody responses following SHIV-SF162P3 challenge. (2014) (0)
- Safety, tolerability, and immunogenicity of inactivated poliovirus vaccine with or without E.coli double mutant heat-labile toxin (dmLT) adjuvant in healthy adults; a phase 1 randomized study (2023) (0)
- G-102 Fine epitope signature of HIV-1 antibody neutralization breadth at the CD4 binding site (2017) (0)
- Mucosal immunity to poliovirus (2021) (0)
- Targeting the tight junction : immunotherapy of colon cancer (2009) (0)
- Evidence that CD32a does not mark the HIV-1 latent reservoir (2018) (0)
- Developing a quantitative model of antibody effector function (2012) (0)
- Impact of adjuvants on the biophysical and functional characteristics of HIV vaccine-elicited antibodies in humans (2022) (0)
- IgG is differentially and selectively transferred across the placenta in HIV-infected women (2018) (0)
- Impact of adjuvants on the biophysical and functional characteristics of HIV vaccine-elicited antibodies in humans (2022) (0)
- Corrigendum to “A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples” (2012) (0)
- Toward high-throughput engineering techniques for improving CAR intracellular signaling domains (2023) (0)
- 2002 Research Honors Program Abstracts (2002) (0)
- Leveraging deep learning to improve vaccine design. (2023) (0)
- An antibody tag-team: driving neutralization through escape. (2014) (0)
- Characterization of heterologous HIV-1 Tier 2 neutralizing mAbs cloned from a macaque immunized with viral quasispecies present in a human subject with neutralization breadth (2019) (0)
- Foundations for improved vaccine correlate of risk analysis using positive-unlabeled learning. (2023) (0)
- Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features (2021) (0)
- Antibody subclass skewing predicts enhanced ADCC activity in both natural infection and vaccination (2012) (0)
- Antibody subclass skewing predicts enhanced ADCC activity in both natural infection and vaccination (2012) (0)
- Developing a quantitative model of antibody effector function (2012) (0)
- Vector induced skewing of antibody Fc-effector functions (2012) (0)
- OPTH_A_337360 4431..4438 (2021) (0)
- Yeast surface display of HIV Env protein variants for the discovery of novel vaccine immunogens (2012) (0)
- Yeast surface display of HIV Env protein variants for the discovery of novel vaccine immunogens (2012) (0)
- Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis (2022) (0)
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What Schools Are Affiliated With Margaret Ackerman?
Margaret Ackerman is affiliated with the following schools:
