Margaret Oakley Dayhoff

Margaret Oakley Dayhoff's AcademicInfluence.com Rankings

Biology

#1828

Historical Rank

Biochemistry

#1293

Historical Rank

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Biology

Margaret Oakley Dayhoff's Degrees

PhD Pharmaceutical Chemistry Columbia University
Masters Pharmaceutical Chemistry Columbia University
Bachelors Chemistry Pennsylvania State University

Why Is Margaret Oakley Dayhoff Influential?

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According to Wikipedia, Margaret Belle Dayhoff was an American physical chemist and a pioneer in the field of bioinformatics. Dayhoff was a professor at Georgetown University Medical Center and a noted research biochemist at the National Biomedical Research Foundation, where she pioneered the application of mathematics and computational methods to the field of biochemistry. She dedicated her career to applying the evolving computational technologies to support advances in biology and medicine, most notably the creation of protein and nucleic acid databases and tools to interrogate the databases. She originated one of the first substitution matrices, point accepted mutations . The one-letter code used for amino acids was developed by her, reflecting an attempt to reduce the size of the data files used to describe amino acid sequences in an era of punch-card computing.

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Margaret Oakley Dayhoff's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Atlas of protein sequence and structure (1965) (5830)
A model of evolutionary change in protein (1978) (1127)
Establishing homologies in protein sequences. (1983) (978)
Origins of prokaryotes, eukaryotes, mitochondria, and chloroplasts. (1978) (489)
A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha 1-proteinase inhibitor. (1980) (381)
Evolution of the Structure of Ferredoxin Based on Living Relics of Primitive Amino Acid Sequences (1966) (376)
Data bank (1981) (220)
Amino-terminal sequence identity of ubiquitin and the nonhistone component of nuclear protein A24. (1977) (167)
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase. (1982) (160)
The Partial Specific Volumes, in Aqueous Solution, of Three Proteins (1952) (123)
Computer analysis of protein evolution. (1969) (123)
The origin and evolution of protein superfamilies. (1976) (94)
Epidermal growth factor: internal duplication and probable relationship to pancreatic secretory trypsin inhibitor. (1974) (81)
Sequence similarity between cholera toxin and glycoprotein hormones: implications for structure activity relationship and mechanism of action. (1976) (79)
The occurrence in proteins of the tripeptides Asn-X-Ser and Asn-X-Thr and of bound carbohydrate. (1970) (70)
Atlas of Protein Sequence and Structure, 1972. (1973) (68)
Evolution of lipoproteins deduced from protein sequence data. (1977) (63)
Thermodynamic Equilibrium and the Inorganic Origin of Organic Compounds (1966) (62)
Thermodynamic Equilibria in Planetary Atmospheres (1967) (58)
Thermodynamic Equilibria in Prebiological Atmospheres (1964) (56)
Computer aids to protein sequence determination. (1965) (53)
DELTA FUNCTION MODEL OF CHEMICAL BINDING (1960) (50)
Methods for identifying proteins by using partial sequences. (1979) (47)
Evolution of proteins. (1971) (46)
Protein and Nucleic Acid Sequence Database Systems. (1983) (44)
Organic Molecules and the Coloration of Jupiter (1967) (42)
Nucleic acid sequence database IV. (1982) (42)
EVIDENCE ON THE ORIGIN OF EUKARYOTIC MITOCHONDRIA FROM PROTEIN AND NUCLEIC ACID SEQUENCES * (1981) (42)
A contour-map program for x-ray crystallography (1963) (35)
The Partial Molal Volumes of Potassium Chloride, Potassium and Sodium Iodides and of Iodine in Aqueous Solution at 25° (1952) (34)
Venus: Atmospheric Evolution (1967) (32)
A Magnetic Float Method for Determining the Densities of Solutions (1951) (30)
ukaryotes versus Prokaryotes: An Estimate of Evolutionary Distance (1970) (28)
Comprotein: a computer program to aid primary protein structure determination (1962) (28)
CHLOROPLAST ORIGINS: INFERENCES FROM PROTEIN AND NUCLEIC ACID SEQUENCES * (1981) (28)
A comprehensive examination of protein sequences for evidence of internal gene duplication (1978) (26)
Protein and nucleic Acid sequence data and phylogeny. (1979) (25)
Computer analysis of protein sequences. (1974) (25)
Evolutionary connections of biological kingdoms based on protein and nucleic acid sequence evidence (1983) (20)
Evolution of sequences within protein superfamilies (1975) (20)
Inferences from protein and nucleic acid sequences: Early molecular evolution, divergence of kingdoms and rates of change (1974) (17)
Nucleic acid sequence bank. (1980) (14)
Evolution of major metabolic innovations in the Precambrian (1982) (13)
Thermodynamic models in cosmochemical systems (1972) (11)
TABLE OF ABNORMAL HUMAN GLOBINS * : With References (1974) (10)
Evolutionary and Functional Relationships of Homologous Physiological Mechanisms (1980) (9)
Nucleic acid sequence database. (1981) (9)
The Apparent and Partial Molal Volumes of Potassium Iodide and of Iodine in Methanol at 25° from Density Measurements (1953) (7)
MASSPEC: a computer program for complete sequence analysis of large proteins from mass spectrometry data of a single sample. (1970) (7)
Prokaryote evolution and the symbiotic origin of eukaryotes (1980) (6)
Evolution of homologous physiological mechanisms based on protein sequence data. (1979) (5)
Computer Search for Active Site Configurations (1964) (5)
The origin of the genetic material in the abnormally long human hemoglobin and chains. (1972) (5)
A Study of Iodide‐Iodine Solutions with the emf Centrifuge (1952) (4)
Sequence evidence for the symbiotic origins of chloroplasts and mitochondria (1983) (4)
Origins of immunoglobulin heavy chain domains (1980) (3)
Sequence bank update. Nucleic acid sequence database II. (1982) (3)
Evolution of Chromosomal Proteins (1982) (3)
Identifying unknown proteins (1983) (3)
Thermodynamic Equilibrium in the Origin of Organic Matter (1966) (2)
The point mutation process in proteins (1978) (2)
Protein identification system: methods of searching for similar sequences (1983) (2)
Table of abnormal human globins. (1974) (2)
Investigation of thermodynamic mechanisms for the production of compounds essential for the origin of life First quarter technical report, Oct. 1 - Dec. 31, 1965 (1965) (1)
ORIGINS OF PROKARYOTES, EUKARYOTES, MITOCHONDRIA AND CHLOROPLASTS: A PERSPECTIVE DERIVED FROM SEQUENCE DATA (1981) (1)
Nucleic Acid Sequence Database V: completely sequenced genomes. (1983) (1)
DELTA FUNCTION MODEL FOR THE $H^{+}_{3}$ AND $H_{2}$ MOLECULES (1958) (0)
Evolution of early life inferred from protein and ribonucleic acid sequences (1978) (0)
Evolution of the Rhodospirillaceae and Mitochondria: A View Based on Sequence Data (1981) (0)
The Evolution of Blue-Greens and the Origins of Chloroplasts (1981) (0)
Atlas of protein sequence and structure 1969 vol 4 (1969) (0)
Early Biological Evolution Derived from Chemical Structures (1980) (0)
Investigation of compounds essential for the origin of life (1983) (0)
Informational Biopolymer Structure in Early Living Forms (1972) (0)
Investigation of thermodynamic mechanisms for the production of complex compounds essential for the origin of life Final report, 1 Oct. 1965 - 30 Sep. 1966 (1966) (0)
The chemical structure of DNA sequence signals for RNA transcription (1982) (0)
Nucleic acid sequence database III. (1982) (0)
Phylogenetic sequence of metabolic pathways in Precambrian cellular life (1981) (0)

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Margaret Oakley Dayhoff's Academic­Influence.com Rankings