Margaret A. Phillips
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American biologist
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Margaret A. Phillipsbiology Degrees
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Molecular Biology
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Biology
Margaret A. Phillips's Degrees
- Bachelors Biology University of California, Berkeley
- PhD Molecular Biology Stanford University
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Why Is Margaret A. Phillips Influential?
(Suggest an Edit or Addition)According to Wikipedia, Margaret A. Phillips is an American biologist who is the Sam G. Winstead and F. Andrew Bell Distinguished Chair in Biochemistry at the University of Texas Southwestern Medical Center. She was elected a Fellow of the National Academy of Sciences in 2021.
Margaret A. Phillips's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Chemical genetics of Plasmodium falciparum (2010) (528)
- Modeling of the spatial structure of eukaryotic ornithine decarboxylases (1995) (314)
- Targeted Nanodelivery of Drugs and Diagnostics. (2010) (275)
- A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria (2015) (273)
- Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. (2011) (246)
- Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. (2009) (210)
- Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. (2008) (185)
- High-throughput Screening for Potent and Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase* (2005) (174)
- Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. (2010) (171)
- An Alternative Polyamine Biosynthetic Pathway Is Widespread in Bacteria and Essential for Biofilm Formation in Vibrio cholerae* (2009) (162)
- Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition. (1987) (154)
- Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. (2011) (143)
- Trypanosome ornithine decarboxylase is stable because it lacks sequences found in the carboxyl terminus of the mouse enzyme which target the latter for intracellular degradation. (1990) (137)
- Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. (2000) (128)
- State of the art in African trypanosome drug discovery. (2011) (127)
- X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine. (1999) (125)
- Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model* (2010) (119)
- Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds* (2009) (108)
- Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection. (2011) (96)
- Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog (2007) (87)
- Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors (2014) (86)
- Malarial Dihydroorotate Dehydrogenase (2002) (84)
- Alternative Spermidine Biosynthetic Route Is Critical for Growth of Campylobacter jejuni and Is the Dominant Polyamine Pathway in Human Gut Microbiota* (2011) (82)
- Proteases (1992) (80)
- Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study (2017) (77)
- Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study (2018) (75)
- Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies (2008) (75)
- The subunit interfaces of oligomeric enzymes are conserved to a similar extent to the overall protein sequences (1994) (74)
- Altering the reaction specificity of eukaryotic ornithine decarboxylase. (2000) (73)
- Formation of functional cross-species heterodimers of ornithine decarboxylase. (1994) (72)
- Anticancer Properties of Distinct Antimalarial Drug Classes (2013) (71)
- Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials. (2012) (71)
- Gene Knockdown of γ-Glutamylcysteine Synthetase by RNAi in the Parasitic Protozoa Trypanosoma brucei Demonstrates That It Is an Essential Enzyme* (2003) (69)
- Regulated Expression of an Essential Allosteric Activator of Polyamine Biosynthesis in African Trypanosomes (2008) (65)
- Acidic Residues Important for Substrate Binding and Cofactor Reactivity in Eukaryotic Ornithine Decarboxylase Identified by Alanine Scanning Mutagenesis (*) (1995) (65)
- Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications (2013) (65)
- Characterization of Trypanosoma brucei γ-Glutamylcysteine Synthetase, an Essential Enzyme in the Biosynthesis of Trypanothione (Diglutathionylspermidine)* (1996) (64)
- A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria. (2016) (61)
- Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening (2016) (59)
- A Trypanosoma brucei mutant resistant to α-difluoromethylornithine (1987) (56)
- Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase. (2012) (53)
- Phylogenetic Diversity and the Structural Basis of Substrate Specificity in the β/α-Barrel Fold Basic Amino Acid Decarboxylases* (2007) (52)
- Evolution and Multifarious Horizontal Transfer of an Alternative Biosynthetic Pathway for the Alternative Polyamine sym-Homospermidine*♦ (2010) (52)
- Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export (2012) (52)
- Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase. (2008) (50)
- Structure Prediction and Active Site Analysis of the Metal Binding Determinants in γ-Glutamylcysteine Synthetase* (2001) (47)
- Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis (2016) (47)
- SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity. (2013) (46)
- RNA Interference-Mediated Silencing of Ornithine Decarboxylase and Spermidine Synthase Genes in Trypanosoma brucei Provides Insight into Regulation of Polyamine Biosynthesis (2009) (45)
- Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics. (2011) (45)
- Trypanosoma brucei ornithine decarboxylase: enzyme purification, characterization, and expression in Escherichia coli. (1988) (43)
- Allosteric Activation of Trypanosomatid Deoxyhypusine Synthase by a Catalytically Dead Paralog*♦ (2013) (42)
- Regulation and function of polyamines in African trypanosomes. (2012) (42)
- Lysine-69 plays a key role in catalysis by ornithine decarboxylase through acceleration of the Schiff base formation, decarboxylation, and product release steps. (1999) (40)
- Long-range interactions in the dimer interface of ornithine decarboxylase are important for enzyme function. (2001) (40)
- Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity (2016) (40)
- Phosphatidylinositol 4-Kinase III-β Is Required for Golgi Maintenance and Cytokinesis in Trypanosoma brucei (2007) (39)
- Role of Arg-277 in the binding of pyridoxal 5'-phosphate to Trypanosoma brucei ornithine decarboxylase. (1997) (38)
- Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis (2009) (37)
- Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase. (2004) (36)
- Paramecium bursaria Chlorella Virus-1 Encodes an Unusual Arginine Decarboxylase That Is a Close Homolog of Eukaryotic Ornithine Decarboxylases* (2004) (36)
- A Multiple Aminoacyl-tRNA Synthetase Complex That Enhances tRNA-Aminoacylation in African Trypanosomes (2013) (36)
- Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH) (2015) (31)
- X-ray Structure Determination of Trypanosoma brucei Ornithine Decarboxylase Bound to d-Ornithine and to G418 (2003) (30)
- Discovery of Potent and Selective Inhibitors of Trypanosoma brucei Ornithine Decarboxylase* (2010) (29)
- Cellular evaluation of synthesized insulin/transferrin bioconjugates for oral insulin delivery using intelligent complexation hydrogels. (2010) (29)
- Domain organization and a protease-sensitive loop in eukaryotic ornithine decarboxylase. (1995) (29)
- GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway (2015) (29)
- Trypanosoma brucei gamma-glutamylcysteine synthetase. Characterization of the kinetic mechanism and the role of Cys-319 in cystamine inactivation. (1998) (28)
- Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397. (2003) (28)
- Guanidine derivatives restore activity to carboxypeptidase lacking arginine‐127 (1992) (27)
- Genetic Validation of Aminoacyl-tRNA Synthetases as Drug Targets in Trypanosoma brucei (2014) (27)
- Mechanisms of allosteric regulation of Trypanosoma cruzi S-adenosylmethionine decarboxylase. (2006) (27)
- Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. (2018) (27)
- Polyamines in protozoan pathogens (2018) (26)
- Catalysis and regulationProteases (1992) (25)
- A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei. (2011) (25)
- Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins* (2015) (25)
- Characterization of the reaction mechanism for Trypanosoma brucei ornithine decarboxylase by multiwavelength stopped-flow spectroscopy. (1997) (24)
- The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions. (2015) (23)
- Characterization of Trypanosoma brucei pyridoxal kinase: purification, gene isolation and expression in Escherichia coli. (1997) (23)
- Assessing drug efficacy against Plasmodium falciparum liver stages in vivo. (2018) (22)
- X-ray structure of Paramecium bursaria Chlorella virus arginine decarboxylase: insight into the structural basis for substrate specificity. (2007) (22)
- Detergent-dependent Kinetics of Truncated Plasmodium falciparumDihydroorotate Dehydrogenase* (2007) (22)
- Cross-species activation of trypanosome S-adenosylmethionine decarboxylase by the regulatory subunit prozyme. (2009) (22)
- The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity* (2004) (21)
- Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei (2016) (21)
- Cloning and kinetic characterization of the Trypanosoma cruzi S-adenosylmethionine decarboxylase. (1999) (21)
- Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine. (2010) (20)
- Putrescine activation of Trypanosoma cruzi S-adenosylmethionine decarboxylase. (2002) (19)
- Stoking the drug target pipeline for human African trypanosomiasis (2012) (19)
- Malarial dihydroorotate dehydrogenase: substrate and inhibitor specificity. (2002) (19)
- Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT). (2009) (17)
- A Teach-Discover-Treat Application of ZincPharmer: An Online Interactive Pharmacophore Modeling and Virtual Screening Tool (2015) (17)
- Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog (2016) (17)
- Substrate Binding Determinants of Trypanosoma brucei γ-Glutamylcysteine Synthetase† (2002) (16)
- Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs. (2018) (16)
- Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases. (2007) (16)
- Trypanosoma brucei S-Adenosylmethionine Decarboxylase N Terminus Is Essential for Allosteric Activation by the Regulatory Subunit Prozyme* (2013) (16)
- Product feedback regulation implicated in translational control of the Trypanosoma brucei S‐adenosylmethionine decarboxylase regulatory subunit prozyme (2013) (16)
- Prized malaria drug target nailed (2003) (15)
- X-ray Structure Determination of Trypanosoma brucei Ornithine Decarboxylase Bound to D-Ornithine and to G418 INSIGHTS INTO SUBSTRATE BINDING AND ODC CONFORMATIONAL FLEXIBILITY* (2003) (15)
- Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity (2018) (14)
- Carbon-13 isotope effect studies of Trypanosoma brucei ornithine decarboxylase. (1998) (14)
- Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes. (2010) (14)
- A Trypanosoma brucei mutant resistant to alpha-difluoromethylornithine. (1987) (14)
- Genetic Validation of Trypanosoma brucei Glutathione Synthetase as an Essential Enzyme (2014) (13)
- Target validation for drug discovery in parasitic organisms. (2002) (12)
- Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. (2021) (12)
- Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of Malaria. (2020) (12)
- Atovaquone Tolerance in Plasmodium falciparum Parasites Selected for High-Level Resistance to a Dihydroorotate Dehydrogenase Inhibitor (2014) (12)
- Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif (2010) (11)
- Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay. (2017) (11)
- Crystallization and preliminary X‐ray studies of ornithine decarboxylase from Trypanosoma brucei (1996) (11)
- Single-turnover kinetic analysis of Trypanosoma cruzi S-adenosylmethionine decarboxylase. (2000) (10)
- Why do costings? (1987) (10)
- Application of an almost traceless linker in the synthesis of 2-alkylthiobenzimidazole combinatorial libraries (2004) (8)
- Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. (2018) (7)
- Evolution of Substrate Specificity within a Diverse Family of β/α-Barrel-fold Basic Amino Acid Decarboxylases (2010) (7)
- Trypanosoma brucei γ-Glutamylcysteine Synthetase (1998) (7)
- Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. (2017) (6)
- Circular dichroism assay for decarboxylation of optically pure amino acids: application to ornithine decarboxylase. (1996) (6)
- Trypanosoma brucei: effects of methoprene and other isoprenoid compounds on procyclic and bloodstream forms in vitro and in mice. (1997) (5)
- Total synthesis of (+)-spiroindimicin A and congeners unveils their antiparasitic activity (2021) (5)
- Alternative pathways utilize or circumvent putrescine for biosynthesis of putrescine-containing rhizoferrin (2020) (5)
- Discovery of ancestral L-ornithine and L-lysine decarboxylases reveals parallel, pseudoconvergent evolution of polyamine biosynthesis (2021) (5)
- Substrate binding determinants of Trypanosoma brucei gamma-glutamylcysteine synthetase. (2002) (4)
- Toward a chemical vaccine for malaria (2018) (4)
- Improved Synthesis of MDL 73811 – A Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound (2016) (4)
- A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei (2018) (4)
- ORNITHINE DECARBOXYLASE FROM TRYPANOSOMA BRUCEI K69A MUTANT IN COMPLEX WITH ALPHA-DIFLUOROMETHYLORNITHINE (1999) (3)
- Polyamine Biosynthesis Provides Insight into Regulation of Trypanosoma brucei Synthase Genes in Ornithine Decarboxylase and Spermidine RNA Interference-Mediated Silencing of (2009) (3)
- The translation initiation site of recombinant Trypanosoma brucei ornithine decarboxylase varies with different promoters. (1992) (3)
- Chapter 3:Antimalarial Agents Targeting Nucleotide Synthesis and Electron Transport: Insight from Structural Biology (2011) (3)
- Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum. (2021) (3)
- Medicinal Chemistry Case History: Discovery of the Dihydroorate Dehydrogenase Inhibitor DSM265 as an Antimalarial Drug Candidate (2017) (3)
- Antizyme Ornithine Decarboxylase (2002) (3)
- High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Vol. 280 (2005) 21847-21853 (2005) (2)
- Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348 (2010) (2)
- Chlorella Virus PBCV-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases (2004) (2)
- Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine) (2014) (1)
- CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI ORNITHINE DECARBOXYLASE (1999) (1)
- Identification and assay of allosteric regulators of S-adenosylmethionine decarboxylase. (2011) (1)
- Identifying new drug targets against African Trypanosomiasis (2012) (1)
- Polyamine and glutathione biosynthetic enzymes from Trypanosoma brucei and Trypanosoma cruzi. (2000) (1)
- High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog (2013) (0)
- X-ray crystal structure of arginine decarboxylase complexed with Arginine from Vibrio vulnificus (2010) (0)
- Erratum: High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (Journal of Biological Chemistry (2005) 280 (21847-21853)) (2005) (0)
- Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM265 (2015) (0)
- Targeting the Polyamine Biosynthetic Pathway in Parasitic Protozoa (2015) (0)
- Structural and mechanistic studies of Trypanosoma brucei ornithine decarboxylase (2000) (0)
- Anti-malarial Activity in the Mouse Model Dihydroorotate Dehydrogenase with Plasmodium falciparum Novel Inhibitors of Molecular Bases of Disease : (2010) (0)
- CRYSTAL STRUCTURE OF HUMAN ORNITHINE DECARBOXYLASE AT 2.1 ANGSTROMS RESOLUTION (2000) (0)
- Crystal structure determination of T. brucei ornithine decarboxylase bound to D-ornithine and to G418 (2003) (0)
- IDENTIFICATION OF PROPRIETARY DRUGS (1960) (0)
- Crystal Structure of ThrH gene product of Pseudomonas Aeruginosa (2004) (0)
- Trypanosoma brucei deoxyhypusine synthase (2018) (0)
- A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL) (2022) (0)
- Enzyme-cofactor interactions in eukaryotic ornithine decarboxylase (1996) (0)
- Towards the synthesis of isotopically labelled α-amino acids. (2005) (0)
- Fluoroacetamide and some derivatives as pesticides. (1960) (0)
- The BOINC Project (2011) (0)
- Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidine) (2016) (0)
- Allostery in motion: Trypanosoma brucei enzyme brought to life by a dead paralog (2017) (0)
- A Dimer interface mutant of ornithine decarboxylase reveals structure of gem diamine intermediate (2004) (0)
- Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii. (2022) (0)
- Functional polyamine metabolic enzymes and pathways encoded by the virosphere (2023) (0)
- A satisfactory addition to the armoury. (1960) (0)
- Pseudoenzymes as Activators of Enzyme Function: The Prozyme Paradigm in Trypanosomatid Polyamine Metabolism (2015) (0)
- Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM74 (2009) (0)
- Total Synthesis of (+)-Spiroindimicin A via Asymmetric Palladium-Catalyzed Spirocyclization (2021) (0)
- A Just Reward (1965) (0)
- Trypanosomesion in African Complex That Enhances A Multiple Aminoacyl-tRNA Synthetase (2013) (0)
- Crystal structure of carboxynorspermidine decarboxylase complexed with Norspermidine from Campylobacter jejuni (2010) (0)
- The X-ray Crystal Structure of the Paramecium bursaria Chlorella virus arginine decarboxylase (2007) (0)
- Crystal structure of lysine/ornithine decarboxylase complexed with cadaverine from Vibrio vulnificus (2007) (0)
- CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI ORNITHINE DECARBOXYLASE (ODC) COMPLEXED WITH PUTRESCINE, ODC'S REACTION PRODUCT. (2000) (0)
- The X-ray crystal structure of the Paramecium bursaria Chlorella virus arginine decarboxylase bound to agmatine (2007) (0)
- Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with inhibitor CGP 40215 (2017) (0)
- Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1 (2018) (0)
- Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568 (2018) (0)
- Genetic validation of Trypanosoma brucei glutathione synthetase as an 1 essential enzyme 2 3 (2014) (0)
- Crystal structure of Trypanosoma brucei AdoMetDC-delta26 monomer (2016) (0)
- Structure of N-citrylornithine decarboxylase bound with PLP (2020) (0)
- Development of a biomarker to monitor target engagement after treatment with dihydroorotate dehydrogenase inhibitors. (2022) (0)
- Polysaccharide decoration of complexation hydrogel networks for oral protein delivery (2011) (0)
- Rat dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine) (2014) (0)
- Author response: Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog (2016) (0)
- Structure of Phosphate complex of ThrH from Pseudomonas aeruginosa (2004) (0)
- Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer (2017) (0)
- High resolution crystal structure of human dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine) (2014) (0)
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