Maria Abbracchio

Q: What Schools Are Affiliated With Maria Abbracchio

Maria Abbracchio is affiliated with the following schools: University of Milan, University of Pavia, University of Texas Health Science Center at Houston

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Maria Abbracchio

Medical

#1303

World Rank

#1629

Historical Rank

Pharmacology

#229

World Rank

#269

Historical Rank

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Maria Abbracchio's Degrees

PhD Pharmacology University of Milan

Why Is Maria Abbracchio Influential?

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According to Wikipedia, Maria Pia Abbracchio is an Italian pharmacologist who researches the biochemical effect of drugs at the cellular level. She has conducted research all over the world and is one of the scientists Thomson Reuters has named as most cited scientists since 2006. She is known for her work with purinergic receptors and identification of GPR17. In 2014 she was awarded the Order of Merit of the Italian Republic for her individual scientific accomplishments.

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Maria Abbracchio's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Nomenclature and classification of purinoceptors. (1994) (1631)
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy (2006) (1240)
Purinoceptors: are there families of P2X and P2Y purinoceptors? (1994) (1123)
Purinergic signalling in the nervous system: an overview (2009) (787)
Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells (1996) (456)
Purinergic signalling: pathophysiological roles. (1998) (442)
Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. (2003) (442)
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl‐leukotrienes receptor (2006) (392)
Purinergic signalling: From normal behaviour to pathological brain function (2011) (378)
Towards a revised nomenclature for P1 and P2 receptors. (1997) (361)
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview (2017) (266)
Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines (2004) (241)
Nucleotide‐mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors (2003) (237)
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors (2021) (212)
The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair (2008) (207)
Adenosine receptors and neurological disease: neuroprotection and neurodegeneration. (2009) (202)
G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain. (1995) (200)
Purinergic signalling in inflammation of the central nervous system (2009) (196)
To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders? (2005) (178)
Phenotypic Changes, Signaling Pathway, and Functional Correlates of GPR17-expressing Neural Precursor Cells during Oligodendrocyte Differentiation* (2011) (153)
Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia (2005) (151)
Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum (1994) (148)
A role for P2X7 in microglial proliferation (2006) (143)
Blockade of A2A adenosine receptors prevents basic fibroblast growth factor‐induced reactive astrogliosis in rat striatal primary astrocytes (2003) (134)
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug (2015) (131)
Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor. (2004) (120)
Calcitonin Gene-Related Peptide-Mediated Enhancement of Purinergic Neuron/Glia Communication by the Algogenic Factor Bradykinin in Mouse Trigeminal Ganglia from Wild-Type and R192Q Cav2.1 Knock-In Mice: Implications for Basic Mechanisms of Migraine Pain (2011) (114)
Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists. (1997) (106)
Functions, dysfunctions and possible therapeutic relevance of adenosine A2A receptors in Huntington's disease (2007) (106)
The GPR17 receptor in NG2 expressing cells: Focus on in vivocell maturation and participation in acute trauma and chronic damage (2011) (101)
Roles of P2 receptors in glial cells: focus on astrocytes (2006) (101)
Changes of peripheral A2A adenosine receptors in chronic heart failure and cardiac transplantation (2003) (99)
Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus (2010) (98)
Purinoceptor-mediated calcium signaling in primary neuron-glia trigeminal cultures. (2008) (96)
Brain Adenosine Receptors as Targets for Therapeutic Intervention in Neurodegenerative Diseases (1999) (94)
The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. (2009) (94)
Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure (2019) (93)
Purinoceptor nomenclature: A status report (1993) (93)
Adenosine-induced cell death: evidence for receptor-mediated signalling (1999) (91)
Characterization of the Ca2+ responses evoked by ATP and other nucleotides in mammalian brain astrocytes (1997) (89)
Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells. (2004) (89)
Aberrant amplification of A2A receptor signaling in striatal cells expressing mutant huntingtin (2001) (87)
Characterization of the signalling pathways involved in ATP and basic fibroblast growth factor‐induced astrogliosis (1997) (87)
Modulation of Apoptosis by Adenosine in the Central Nervous System: a Possible Role for the A3 Receptor (1997) (87)
A novel action for adenosine: apoptosis of astroglial cells in rat brain primary cultures. (1995) (86)
Induction of COX‐2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling (2002) (78)
Factors influencing the phagocytosis, neoplastic transformation, and cytotoxicity of particulate nickel compounds in tissue culture systems. (1981) (77)
A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation. (2002) (77)
Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease (2006) (76)
Apoptosis by 2-chloro-2′-deoxy-adenosine and 2-chloro-adenosine in human peripheral blood mononuclear cells (1998) (74)
CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors. (2005) (73)
CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation (2005) (70)
The phagocytosis and transforming activity of crystalline metal sulfide particles are related to their negative surface charge. (1982) (68)
Prolonged in vitro exposure of rat brain slices to adenosine analogues: selective desensitization of adenosine A1 but not A2 receptors. (1992) (67)
P2Y2 receptor antagonists as anti‐allodynic agents in acute and sub‐chronic trigeminal sensitization: Role of satellite glial cells (2015) (67)
GPR17 expressing NG2‐Glia: Oligodendrocyte progenitors serving as a reserve pool after injury (2016) (66)
Extrinsic Purinergic Regulation of Neural Stem/Progenitor Cells: Implications for CNS Development and Repair (2012) (66)
Microglia is a Key Player in the Reduction of Stroke Damage Promoted by the New Antithrombotic Agent Ticagrelor (2014) (66)
Key concepts and critical issues on epoetin and filgrastim biosimilars. A position paper from the Italian Society of Hematology, Italian Society of Experimental Hematology, and Italian Group for Bone Marrow Transplantation (2011) (65)
CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17 (2016) (64)
P1 receptors and cytokine secretion (2007) (64)
Expression and contribution of satellite glial cells purinoceptors to pain transmission in sensory ganglia: an update. (2010) (64)
P1 and P2 receptors in cell growth and differentiation (1996) (63)
Effects of ATP analogues and basic fibroblast growth factor on astroglial cell differentiation in primary cultures of rat striatum (1995) (63)
Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor. (2010) (62)
The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke (2017) (61)
In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases (2011) (59)
Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury (2013) (57)
The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor. (2005) (55)
Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases (2017) (55)
Different pathways of apoptosis revealed by 2‐chloro‐adenosine and deoxy‐D‐ribose in mammalian astroglial cells (1997) (54)
Pathophysiological roles of P2 receptors in glial cells. (2006) (54)
GPR17: Molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors (2008) (54)
P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFalpha and potential role in myocardial cell death. (2005) (52)
Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells. (2009) (52)
Adenosine A3 receptors and viability of astrocytes (1998) (49)
Modulation of Cyclooxygenase‐2 and Brain Reactive Astrogliosis by Purinergic P2 Receptors (2001) (48)
Cytoplasmic dissolution of phagocytized crystalline nickel sulfide particles: a prerequisite for nuclear uptake of nickel. (1982) (48)
Purinergic and Pyrimidinergic Signalling II (2001) (47)
Development of an immobilized GPR17 receptor stationary phase for binding determination using frontal affinity chromatography coupled to mass spectrometry. (2009) (47)
MiR-125a-3p timely inhibits oligodendroglial maturation and is pathologically up-regulated in human multiple sclerosis (2016) (47)
European Stroke Prevention Study-2 results: serendipitous demonstration of neuroprotection induced by endogenous adenosine accumulation? (1998) (46)
Early phenotypic asymmetry of sister oligodendrocyte progenitor cells after mitosis and its modulation by aging and extrinsic factors (2015) (45)
Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17. (2010) (45)
Oxygen–glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood–brain barrier (2011) (45)
Adenosine A3 receptor agonist‐induced neurotoxicity in rat cerebellar granule neurons (1997) (45)
Upregulation of A2A adenosine receptor expression by TNF-alpha in PBMC of patients with CHF: a regulatory mechanism of inflammation. (2005) (45)
A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells. (2003) (44)
Adenosine, the imperfect endogenous anti-ischemic cardio-neuroprotector (2000) (44)
The Regulated Expression, Intracellular Trafficking, and Membrane Recycling of the P2Y-like Receptor GPR17 in Oli-neu Oligodendroglial Cells* (2013) (41)
Different properties of P2X7 receptor in hippocampal and cortical astrocytes (2009) (39)
Cardiovascular, respiratory, immune, metabolic, and gastrointestinal tract function (2001) (38)
Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death (2012) (38)
Differential local tissue permissiveness influences the final fate of GPR17‐expressing oligodendrocyte precursors in two distinct models of demyelination (2018) (37)
Role of purinergic signalling in neuro-immune cells and adult neural progenitors. (2011) (36)
Microencephalic Rats as a Model for Cognitive Disorders (1986) (36)
Oxysterols act as promiscuous ligands of class-A GPCRs: in silico molecular modeling and in vitro validation. (2014) (36)
Biological abnormalities of peripheral A2A receptors in a large representation of polyglutamine disorders and Huntington's disease stages (2007) (36)
Signalling mechanisms involved in P2Y receptor-mediated reactive astrogliosis. (1999) (35)
Purines regulate adult brain subventricular zone cell functions: Contribution of reactive astrocytes (2014) (34)
Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways? (2014) (34)
Trophic roles of P2 purinoceptors in central nervous system astroglial cells. (1996) (33)
Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis. (2020) (31)
Adenosine modulates the dopaminergic function in the nigro-striatal system by interacting with striatal dopamine dependent adenylate cyclase. (1987) (30)
A novel gliotic P2 receptor mediating cyclooxygenase-2 induction in rat and human astrocytes. (2000) (30)
Resistance of Human Astrocytoma Cells to Apoptosis Induced by Mitochondria-Damaging Agents: Possible Implications for Anticancer Therapy (2005) (29)
Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach (2010) (28)
Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice (2020) (28)
Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti‐asthmatic drug (2019) (28)
Loss of intrinsic striatal neurons after methylazoxymethanol acetate treatment in pregnant rats. (1984) (27)
Purple Corn Extract as Anti-allodynic Treatment for Trigeminal Pain: Role of Microglia (2018) (26)
Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study (2013) (26)
Adenosine- and 2-chloro-adenosine-induced cytopathic effects on myoblastic cells and myotubes: involvement of different intracellular mechanisms (2000) (24)
Regulation and signaling of the GPR17 receptor in oligodendroglial cells. (2020) (24)
Trophic Roles of Purines and Pyrimidines (2001) (24)
Molecular, nervous, and urogenitary system function (2001) (24)
Functional genomic analyses highlight a shift in Gpr17‐regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum (2021) (22)
Cardiomyocyte death induced by ischaemic/hypoxic stress is differentially affected by distinct purinergic P2 receptors (2012) (21)
Pharmacological Properties and Biological Functions of the GPR17 Receptor, a Potential Target for Neuro-Regenerative Medicine. (2017) (21)
Differences in surface properties of amorphous and crystalline metal sulfides may explain their toxicological potency (1981) (21)
Adenosine Receptors in Health and Disease (2009) (20)
Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination (2020) (19)
In vivo silencing of miR-125a-3p promotes myelin repair in models of white matter demyelination. (2020) (19)
Selective activity of bamifylline on adenosine A1-receptors in rat brain. (1987) (19)
Short‐term TNF‐Alpha treatment induced A2B adenosine receptor desensitization in human astroglial cells (2008) (19)
Involvement of arachidonic acid metabolites in beta-adrenoceptor desensitization: functional and biochemical studies. (1984) (18)
Deorphanisation of G protein-coupled receptors: A tool to provide new insights in nervous system pathophysiology and new targets for psycho-active drugs (2008) (17)
The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury (2010) (17)
Basal astrocyte and microglia activation in the central nervous system of Familial Hemiplegic Migraine Type I mice (2019) (17)
Methylazoxymethanol-induced microencephaly: persistent increase of cortical somatostatin-like immunoreactivity. (1989) (17)
SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation (2016) (17)
Lupin Peptide T9 (GQEQSHQDEGVIVR) Modulates the Mutant PCSK9D374Y Pathway: in vitro Characterization of its Dual Hypocholesterolemic Behavior (2019) (16)
Chronic inflammatory diseases: Do immunological patterns drive the choice of biotechnology drugs? A critical review (2014) (16)
Expression of dual Nucleotides/Cysteinyl-Leukotrienes Receptor GPR17 in early trafficking of cardiac stromal cells after myocardial infarction (2014) (16)
Actin cytoskeleton as a target for 2-chloro adenosine: evidence for induction of apoptosis in C2C12 myoblastic cells. (1997) (16)
Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1. (2011) (16)
A Rapid and Efficient Immunoenzymatic Assay to Detect Receptor Protein Interactions: G Protein-Coupled Receptors (2014) (16)
β-Adrenoceptor de sensitization in rat lung: Functional and biochemical aspects (1983) (14)
Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis (2020) (14)
In Memoriam Geoffrey Burnstock: Creator of Purinergic Signaling (2020) (14)
A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro (2016) (14)
A2b receptor mediates adenosine inhibition of taurine efflux from pituicytes (2007) (14)
Adenosine signaling in glioma cells. (2013) (14)
Diabetes-induced alterations of central nervous system G proteins. ADP-ribosylation, immunoreactivity, and gene-expression studies in rat striatum. (1992) (13)
Prolonged agonist exposure induces imbalance of A1 and A2 receptor‐mediated functions in rat brain slices (1993) (13)
Proteasome Inhibitors Potentiate Etoposide-Induced Cell Death in Human Astrocytoma Cells Bearing a Mutated p53 Isoform (2006) (13)
Activation and desensitization of rat A3‐adenosine receptors by selective adenosine derivatives and xanthine‐7‐ribosides (1998) (13)
Purinoceptors on Glial Cells of the Central Nervous System: Functional and Pathologic Implications (1995) (12)
Pain and Nociception (2013) (12)
A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights. (2016) (12)
Early alterations of Gi/Go protein‐dependent transductional processes in the retina of diabetic animals (1991) (12)
Dipeptidyl peptidase-4 inhibitors and sulfonylureas prevent the progressive impairment of the nigrostriatal dopaminergic system induced by diabetes during aging (2020) (11)
Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes (2007) (11)
Intertwining extracellular nucleotides and their receptors with Ca2+ in determining adult neural stem cell survival, proliferation and final fate (2016) (11)
Arachidonic acid metabolites and lung β-adrenoceptor desensitization (1986) (10)
Brain and blood levels of bismuth after oral or parenteral administration of tripotassium-dicitrato bismuthate to rats. (1985) (9)
Adenosine receptors in rat basophilic leukaemia cells: transductional mechanisms and effects on 5‐hydroxytryptamine release (1992) (9)
Behavioral teratology: an inappropriate term for some uninterpretable effects. (1988) (9)
The regulation of ionic nickel uptake and cytotoxicity by specific amino acids and serum components (1982) (9)
The ubiquitin ligase Mdm 2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR 17 receptor desensitization (2015) (9)
Nonprofit foundations spur translational research. (2014) (9)
Arachidonic acid metabolites induced β-adrenoceptor densitization in rat lung in vitro (1985) (8)
Professor Dr. Geoffrey Burnstock (1929–2020) (2020) (8)
P2Y receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (7)
Response: behavioral teratology: what's not in a name. (1989) (7)
Adenosine Signaling in Glioma Cells. (2020) (7)
Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System (2021) (7)
The expanding field of purinergic signalling (2009) (6)
P2Y receptors in brain astroglial cells: Identification of a gliotic P2Y receptor coupled to activation of a calcium‐independent ras/ERK1/2 pathway (2003) (6)
In vivo modulation of striatal phosphoproteins by dopaminergic agents. (1989) (6)
The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients (2021) (6)
Steps towards Collective Sustainability in Biomedical Research. (2018) (6)
Using peripheral blood mononuclear cells to determine proteome profiles in human cardiac failure (2008) (6)
Functional and biochemical modifications of lung beta-adrenoreceptors after in vivo desensitization: prevention by indomethacin. (1986) (5)
The history of the Purine Club: a tribute to Prof. Geoffrey Burnstock (2020) (5)
Pathway-Focused Profiling of Oligodendrocytes Over-Expressing miR-125a-3p Reveals Alteration of Wnt and Cell-to-Cell Signaling (2020) (5)
Disclosing apoptosis in the CNS. (1999) (5)
β-Adrenoceptor desensitization induced by antigen challenge in guinea-pig trachea (1990) (4)
Two distinct P2Y receptors are involved in purine‐ and pyrimidine‐evoked Ca2+ elevation in mammalian brain astrocytic cultures (2000) (4)
Adrenergic-prostaglandin interactions in the respiratory system. (1990) (4)
Beta-adrenoceptor desensitization in the lung. A phenomenon related to prostanoids. (1985) (4)
VI. Nomenclature and Classification of Purinoceptors * (2016) (4)
Pharmacological Control of Calcium and Potassium Homeostasis (1995) (4)
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex. (1983) (4)
Activation of P2-purinoceptors induces differentiation of astroglial cells in rat brain primary cultures (1995) (4)
2-Chloro-adenosine-induced apoptosis in rat brain neuron-glia primary cultures (1995) (4)
CHRONIC CAFFEINE TREATMENT AND ADENOSINE RECEPTORS (1984) (4)
Early postnatal chlordiazepoxide administration: Permanent behavioural effects in the mature rat and possible involvement of the GABA-benzodiazepine system (2004) (4)
Adenosine receptors in rat brain synaptosomes: Receptor characterization and relationships with glutamate release (1993) (4)
Intracellular phosphorylation of chloro‐adenosine analogs is a prerequisite for activation of caspase‐3 and induction of apoptosis in human astrocytoma cells (2003) (3)
Purinergic transmission in brain tumors and its impact on drug development (2015) (3)
Biosimilars and safety issues (2009) (3)
Biochemical and immunological aspects of protein aggregation in neurodegenerative diseases (2014) (3)
TROPHIC ACTIONS OF PURINES (1994) (3)
Involvement of GPR17 in Neuronal Fibre Outgrowth (2021) (3)
Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis (2020) (3)
2-Chloro-adenosine induces a glutamate-dependent calcium response in C2C12 myotubes. (2000) (3)
Ventral tegmental area/substantia nigra and prefrontal cortex rodent organotypic brain slices as an integrated model to study the cellular changes induced by oxygen/glucose deprivation and reperfusion: Effect of neuroprotective agents (2014) (3)
Nickel and nickel compounds. (1976) (3)
EFFECTS OF ADPBETA S AND UTP ON THE RAT URINARY BLADDER SMOOTH MUSCLE (1995) (3)
Purinergic Neurotransmission: An Historical Background (2001) (3)
Purinergic Receptors on Oligodendrocyte Progenitors: Promising Targets for Myelin Repair in Multiple Sclerosis? (2021) (2)
Perspectives on Geoff Burnstock as researcher, teacher and friend. (2020) (2)
Arachidonic acid metabolites induce beta-adrenoceptor desensitization in rat lung in vitro. (1985) (2)
Identification of a novel P2 receptor associated with cyclooxygenase‐2 upregulation and reactive astrogliosis (2001) (2)
The oral reversibly-binding antiplatelet agent, Ticagrelor, acts as an antagonist at the P2Y-like receptor GPR17 (2010) (2)
Forced unbinding of GPR17 ligands from wild-type and R255I mutant receptor models (2008) (2)
Italy: scientists petition against biodynamic farming law (2021) (2)
Cellular effects of ornithine decarboxylase induction in cells maintained with a salts/glucose medium. (1981) (2)
Modulation of cyclooxygenase-2 and brain reactive astrogliosis by P2 receptors (2000) (2)
Beta adrenoceptor desensitization in lung: a role for prostaglandins. (1989) (2)
Reply to: ‘The discovery of a new class of synaptic transmitters in smooth muscle fifty years ago and amelioration of coronary artery thrombosis’ (2013) (2)
Purines 2010: Adenine Nucleosides and Nucleotides in Biomedicine (2010) (2)
Purinergic P2Y(2) receptors on satellite glial cells as new potential targets for the pharmacological control of trigeminal sensitization (2015) (1)
Aberrant A 2A receptor function in peripheral blood cells in Huntington's disease (2003) (1)
Beta-adrenoceptor desensitization in rat lung: functional and biochemical aspects. (1983) (1)
P2Y receptors in GtoPdb v.2021.3 (2021) (1)
Beta-adrenoceptor desensitization induced by antigen challenge in guinea-pig trachea. (1990) (1)
Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells (2022) (1)
P2 receptors mediate cyclo-oxygenase 2 induction in rat astroglial cells (1998) (1)
Agonist-induced desensitisation/resensitisation of human GPR17: a functional cross talk between purinergic and cysteinyl-leukotriene ligands (2012) (1)
The P2Y-like GPR17 receptor participates in oligodendrocyte precursor cell reaction in a model of chronic cerebral amyloidosis (2009) (1)
Protein-phosphorylation in the central nervous system: a possible tool for studying the pharmacological effects of psychotropic drugs (1987) (1)
Functional genomic analyses highlights a shift in Gpr17-regulated cellular processes in oligodendrocyte progenitor cells (OPC) and underlying myelin dysregulation in the aged forebrain (2020) (1)
MODULATION OF GLIAL P2Y RECEPTORS BY ALGOGENIC MEDIATORS IN THE TRIGEMINAL GANGLIA: A ROLE FOR THE PURINERGIC SYSTEM IN THE MECHANISM OF ACTION OF KNOWN ANTI-MIGRAINE DRUGS? (2012) (0)
Corn (ZEA MAYS L). extracts as source of active compounds with promising effects in reducing trigeminal pain through microbiota modulation (2019) (0)
Gene regulation of the receptor GPR17, a key player in oligodendroglial differentiation (2012) (0)
Purinergic neuron/glia communication in trigeminal ganglia : interactions with other algogens and implications for migraine pain (2011) (0)
Microglia-derived extracellular vesicles regulate the proliferation and differentiation of oligodendrocyte precursor cells (2015) (0)
GPR17 molecular modelling: interactions with non-conventional pro-inflammatory ligands (2016) (0)
Gene regulation of the receptor GPR17 in oligodendroglial cells: expression pattern and pathological alterations in a mouse model of multiple sclerosis (2013) (0)
A new miRNA regulating oligodendrocyte maturation in physiology and disease (2016) (0)
SNX27 regulation of GPR17 recycling is important for the correct differentiation of oligodendrocytes (2015) (0)
Purines '96: Molecular, pharmacological and therapeutic advances (1996) (0)
International meeting “Purines 2010: adenosine nucleosides and nucleotides in biomedicine” (2010) (0)
Patent development of new modulators of GPR17, a key receptor in remyelinating processes (2016) (0)
The genetic inhibition of GPR17 affects myelination by influencing important players in oligodendrocyte maturation, including purinergic receptors (2017) (0)
Mesenchymal stem cells drive M2 microglia polarization, associated with protection after acute brain injury : in vitro and in vivo evidence (2012) (0)
Purinergic signaling modulates adult neurogenesis in the subventricular zone: role of parenchymal astrocytes (2012) (0)
SNX27, a protein of the retromer complex, regulates GPR17 recycling and the kinetics of oligodendrocyte differentiation (2016) (0)
A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro (2016) (0)
Role of arachidonic acid metabolites in beta-adrenergic desensitization in lungs. (1987) (0)
Abstract 9940: Novel Function of the P2y/cysteinyl-leukotriene Receptor Gpr17 in Recruitment of Circulating and Resident Myofibroblast Progenitors Following Acute Myocardial Infarction (2012) (0)
Chemical Stimulation of the Subarachnoid Space Recordings From Brain Stem Neurons Responding to (2015) (0)
Modulation of purinergic signaling by algongens in cultures from trigeminal sensory ganglia (2011) (0)
A PDZ binding motif controls G protein-coupled receptor 17 trafficking in differentiating oligodendrocytes (2014) (0)
The P2Y-like GPR17 receptor orchestrates the transition between immature and myelinating oligodendrocytes and is a new target for myelin repair (2010) (0)
[The advent of biosimilars: new rules to guarantee patient safety]. (2009) (0)
Crosstalk between sensory neurons and neuroinflammatory cells in trigeminal ganglia in relation to migraine pain (2011) (0)
Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death (2012) (0)
The P2Y-like GPR17 receptor regulates the differentiation of NG2+ neural precursor cells into mature oligodendrocytes (2012) (0)
Chimeric molecular modeling and high throughput screening of GPR17: towards the identification of new ligands (2010) (0)
Purine modulation of astroglial function (1999) (0)
EXPRESSION AND ACTIVITY OF GPR17, A NEW NUCLEOTIDE-CYSTEINYL-LEUKOTRIENE RECEPTOR, IN NEURONAL PC12 CELL MODEL. (2008) (0)
Role of P2Y purinergic receptors in neuron-glia signaling in trigeminal ganglia: involvement in pain transmission (2010) (0)
G PROTEIN-COUPLED RECEPTOR DESENSITISATION REGULATES STEM CELL DIFFERENTIATION (2016) (0)
An atypical caspase cascade in adenosine analogs-induced apoptosis of human astrocytoma cells (2002) (0)
BEHAVIORAL AND CELLULAR EFFECTS OF CHRONIC TREATMENT WITH 2-CHLORO-N6-CYCLOPENTYLADENOSINE, CCPA, A SELECTIVE A1 ADENOSINE RECEPTOR AGONIST IN THE RAT (1995) (0)
G-proteins and diabetic encephalopathy : molecular mechanisms underlying the functional alterations : V meeting of the Inter-Regional Group Liguria, Lombardia, Piemonte, Valle d'Aosta of the Italian Society of Pharmacology, Brescia, May 24, 1991 (1992) (0)
Differential role of P2Y receptors in agonist-induced Tissue Factor expression by platelets. (2004) (0)
Purinergic signaling and cell proliferation and differentiation in a neuronal pheocromocytoma PC12 cell model (2009) (0)
Acknowledgement to reviewers (2005) (0)
Purinergic and cysteinyl-leukotriene agonists of the GPR17 receptor engender distinctintracellular signalling programs with different functional potentials in oligodendrocyte maturation (2013) (0)
Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis (2020) (0)
Adult neurogenesis in the subventricular zone: studies on the role of purinergic signalling by the neurosphere assay (2010) (0)
A nutraceutical approach as adjuvant therapy for the prevention and treatment of trigeminal pain: role of microglia and of the gut microbiota (2017) (0)
Purinergic neuron/glia communication in the spinal-trigeminal system in vitro and in vivo: implications for basic mechanisms of pain transmission (2011) (0)
Identification of molecular mechanisms underlying oligodendrocyte differentiation (2015) (0)
G-proteins and diabetic encephalopathy: molecular mechanisms underlying the functional alterations. (1992) (0)
A novel action for adenosine suggested by apoptosis of astroglial cells in rat brain primary cultures (1995) (0)
Purines '92: Pharmacology and clinical applications (1993) (0)
Gene regulation of the P2Y-like receptor GPR17 in oligodendrocytes, and pathological alterations in a mouse model of multiple sclerosis (2013) (0)
GPR17, a key receptor involved in oligodendrogenesis: implications for re-myelination strategies (2016) (0)
Role of the P2Y-like receptor GPR17 in neural precursor cells (2012) (0)
Implementation of the stem cell properties of NG2-expressing neural precursor cells by purinergic signaling: an innovative reparative approach to neurodegeneration (2013) (0)
EFFECTS OF PURINES ON ASTROGLIAL FUNCTION (1995) (0)
Pathway-Focused Profiling of Oligodendrocytes Over-Expressing miR-125a-3p Reveals Alteration of Wnt and Cell-to-Cell Signaling (2020) (0)
Pharmacological Properties and Biological 7 Functions of the GPR 17 Receptor , 8 a Potential Target for Neuro-Regenerative (2017) (0)
Arachidonic acid metabolites and lung beta-adrenoceptor desensitization. (1986) (0)
Altered expression of the GPR17 receptor in the spinal cord of SOD1G93A mice, a model of amyotrophic lateral sclerosis (2017) (0)
Overview Identification of a Novel P 2 Receptor Associated With Cyclooxygenase-2 Upregulation and Reactive Astrogliosis (0)
Comparative evaluation of GPR17 ligands in silico and in vitro on cultured primary oligodendrocyte precursor cells (2014) (0)
In search of signals that trigger GPR17 expression in microglia cells (2013) (0)
Glial cell activation in the spinal-trigeminal system in vivo : implications for basic mechanisms of pain transmission (2011) (0)
Oligodendrogenesis: focus on G protein-coupled receptor 17 (GPR17) (2015) (0)
Time-dependent and critical role of the P2Y-like GPR17 receptor at distinct stages of oligodendrocyte differentiation (2012) (0)
Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury (2013) (0)
Expression and function of Uracil nucleotides/Cysteinyl-Leukotrienes dualGPR17 receptor in mouse cardiac derived stem cells (2010) (0)
About the chameleonic behaviour of some β1 and β2 adrenergic ligands (1995) (0)
Extrinsic Purinergic Regulation of Neural Stem/Progenitor Cells: Implications for CNS Development and Repair (2012) (0)
The GPR17 receptor as a new potential pharmacological target to restore oligodendroglial dysfunction in amyotrophic lateral sclerosis (2018) (0)
Behavioral teratology: an inappropriate term for some (1988) (0)
Unveiling mechanisms underlying oligodendrocyte differentiation: new perspectives for the treatment of neurological diseases (2016) (0)
Acknowledgment of Reviewers (2019) (0)
Basic Science and Experimental Studies Upregulation of A 2A Adenosine Receptor Expression by TNF-a in PBMC of Patients With CHF: A Regulatory Mechanism of Inflammation (2005) (0)
A1 and P2Y1 purine receptors:localization and functional cross-talk in hippocampus (2007) (0)
Reduced beta-adrenoceptor functionality after pulmonary anaphylaxis in guinea-pig (1988) (0)
Correction to: The history of the purine Club: a tribute to prof. Geoffrey Burnstock (2021) (0)
Induction of GPR17 receptor expression in microglial cells (2012) (0)
GPR17 expression in healthy and injured spinal cord (2008) (0)
High-throughput screening of potential drug candidates for GPR17 receptor by FAC-MS : development and application of a new GPR17 stationary phase (2008) (0)
Different P2 receptor subtypes are involved in short- and long-term responses induced by nucleotides in mammalian brain astrocytes (1997) (0)
The Dual Behaviour of a GPCR Involved in Brain Damage an Repair: Forced Unbinding of the Receptor GPR17 Ligands from Wild Type and R255I Mutant Models Through a Computational Approach (2010) (0)
Activation of glial cells in the cervical spinal cord and in the trigeminal ganglion following induction of inflammatory pain (2012) (0)
Mir-125a-3p negatively regulates oligodendrocyte precursor cells maturation and is altered in human multiple sclerosis (2017) (0)
The history of the Purine Club: a tribute to Prof. Geoffrey Burnstock (2020) (0)
Regulation Of The P2Y-Like Receptor GPR17 By Agonist-Induced Desensitization (2012) (0)
Adenosine receptors and modulation of mediator release in RBL cells: Functional and transductional correlates (1990) (0)
The purinergic system cooperates with the algogenic factors bradykinin and CGRP in modulating neuron/glia communication in mouse trigeminal ganglia from wild type and R192Q Cav2.1 knock-in mice: implications for basic mechanisms of migraine pain (2011) (0)
Adaptive Changes in an Animal Model of Micro-Encephaly (1988) (0)
Adenosine receptors in neuronal differentiation and aging (1990) (0)
Screening of drug candidates for G-protein-coupled receptors using frontal affinity chromatography coupled to mass spectrometry (2009) (0)
EPHAR Council Meeting, San Francisco, 9 July 2002 (2002) (0)
CGRP-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in trigeminal mouse ganglia : implications for migraine pain (2010) (0)
Gene regulation of GPR17, a checkpoint receptor in oligodendroglial differentiation (2014) (0)
Role of ATP and ATP-metabolizing enzymes in neuroreparative processes after hypoxic-ischemic injury in rodent organotypic brain slices (2010) (0)
Expression pattern and distribution of the oligodendroglial receptor GPR17 in Experimental Autoimmune Encephalomyelitis, a mouse model of Multiple Sclerosis (2013) (0)
Expression pattern of GPR17, a dual receptor for uracil nucleotides and cysteinyl-leukotrienes, during brain ischemia in mice (2008) (0)
Phenotypic heterogeneity of dividing oligodendrocyte progenitor cells and of their progeny : characterization and modulation by aging and extrinsic factors (2015) (0)
AGONIST-INDUCED CHANGES OF ADENOSINE-A1 AND ADENOSINE-A2 RECEPTOR FUNCTION IN RAT-BRAIN SLICES (1993) (0)
DYSREGULATION OF THE GPR17 RECEPTOR IN NEURO-INFLAMMATORY DISEASES: IMPLICATIONS FOR RE-MYELINATION IN MULTIPLE SCLEROSIS (2017) (0)
Characterization of GPR17 expression in oligodendrocyte precursor cells of the postnatal and adult mouse cortex: focus on proliferation activity (2010) (0)
Adenosine-Induced Apoptosis of C 2 C 12 Myoblastic Cells (2007) (0)
Functional Heterodimerization between the G Protein-Coupled Receptor GPR17 and the Chemokine Receptors 2 and 4: New Evidence (2022) (0)
Beta-adrenoceptor desensitization in a model of experimental asthma in guinea-pigs. (1989) (0)
Maria Teresa Miras Portugal (1948–2021): in memoriam (2021) (0)
Role of P2Y receptors in trigeminal pain signalling (2008) (0)

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