Maria Falkenberg
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Swedish biochemist
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Maria Falkenbergbiology Degrees
Biology
#15170
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#19094
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Biochemistry
#2658
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#2840
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Biology
Maria Falkenberg's Degrees
- Bachelors Biochemistry Uppsala University
- PhD Biochemistry Stockholm University
Why Is Maria Falkenberg Influential?
(Suggest an Edit or Addition)According to Wikipedia, Maria Falkenberg is a professor of medical biochemistry at the Sahlgrenska Academy of the University of Gothenburg, Sweden. She has made important contributions to understanding how the mitochondrial genome is maintained in health and disease.
Maria Falkenberg's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Premature ageing in mice expressing defective mitochondrial DNA polymerase (2004) (2426)
- Mitochondrial transcription factor A regulates mtDNA copy number in mammals. (2004) (778)
- DNA replication and transcription in mammalian mitochondria. (2007) (653)
- Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA (2002) (593)
- Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA (2011) (464)
- Maintenance and Expression of Mammalian Mitochondrial DNA. (2016) (442)
- Reconstitution of a minimal mtDNA replisome in vitro (2004) (371)
- TWINKLE Has 5′ → 3′ DNA Helicase Activity and Is Specifically Stimulated by Mitochondrial Single-stranded DNA-binding Protein* (2003) (279)
- Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid (2015) (245)
- Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imaging (2009) (243)
- MTERF3 Is a Negative Regulator of Mammalian mtDNA Transcription (2007) (234)
- Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication. (2010) (181)
- Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro (2008) (165)
- The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells (2004) (162)
- Mammalian transcription factor A is a core component of the mitochondrial transcription machinery (2012) (160)
- G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation (2010) (153)
- Human Mitochondrial Transcription Revisited (2010) (150)
- TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication (2013) (137)
- Conserved Sequence Box II Directs Transcription Termination and Primer Formation in Mitochondria* (2006) (137)
- A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop (2012) (133)
- A family of putative transcription termination factors shared amongst metazoans and plants (2005) (131)
- In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication (2014) (116)
- The human mitochondrial replication fork in health and disease. (2010) (110)
- Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A (2012) (102)
- Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function. (2011) (99)
- MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. (2013) (98)
- Selective mitochondrial DNA degradation following double-strand breaks (2017) (89)
- In vitro-reconstituted nucleoids can block mitochondrial DNA replication and transcription. (2014) (86)
- Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA. (2018) (86)
- Mitochondrial DNA replication in mammalian cells: overview of the pathway (2018) (86)
- Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome* (2011) (78)
- TEFM is a potent stimulator of mitochondrial transcription elongation in vitro (2015) (77)
- Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element (2015) (74)
- Small-molecule inhibitors of human mitochondrial DNA transcription (2020) (73)
- The UL8 Subunit of the Heterotrimeric Herpes Simplex Virus Type 1 Helicase-Primase Is Required for the Unwinding of Single Strand DNA-binding Protein (ICP8)-coated DNA Substrates* (1997) (67)
- The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication (2015) (66)
- In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication (2012) (66)
- The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities (2007) (66)
- A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression (2014) (66)
- Leading and lagging strand DNA synthesis in vitro by a reconstituted herpes simplex virus type 1 replisome. (2000) (61)
- Organization of DNA in Mammalian Mitochondria (2019) (60)
- Structure-function defects of the TWINKLE linker region in progressive external ophthalmoplegia. (2008) (58)
- The accessory subunit B of DNA polymerase γ is required for mitochondrial replisome function (2007) (55)
- Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA (2017) (53)
- SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder. (2019) (52)
- Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria (2018) (48)
- The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis (2011) (48)
- RNase H1 directs origin-specific initiation of DNA replication in human mitochondria (2019) (47)
- Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies (2015) (46)
- MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication (2016) (44)
- Characterization of the mouse genes for mitochondrial transcription factors B1 and B2 (2003) (43)
- Primer removal during mammalian mitochondrial DNA replication. (2015) (40)
- Rep-Dependent Initiation of Adeno-Associated Virus Type 2 DNA Replication by a Herpes Simplex Virus Type 1 Replication Complex in a Reconstituted System (2001) (40)
- Defective mitochondrial protease LonP1 can cause classical mitochondrial disease (2018) (38)
- POLRMT does not transcribe nuclear genes (2014) (37)
- Structure-function defects of the twinkle amino-terminal region in progressive external ophthalmoplegia. (2009) (36)
- Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcription (2010) (34)
- Mitochondrial transcription termination factor 1 directs polar replication fork pausing (2016) (33)
- Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions (2019) (33)
- The Leucine-rich Pentatricopeptide Repeat-containing Protein (LRPPRC) Does Not Activate Transcription in Mammalian Mitochondria* (2013) (30)
- Sequence-specific stalling of DNA polymerase γ and the effects of mutations causing progressive ophthalmoplegia. (2011) (30)
- Herpes simplex virus DNA replication: a spacer sequence directs the ATP-dependent formation of a nucleoprotein complex at oriS. (1994) (29)
- TWINKLE and Other Human Mitochondrial DNA Helicases: Structure, Function and Disease (2020) (29)
- The DNA Ligands Influence the Interactions between the Herpes Simplex Virus 1 Origin Binding Protein and the Single Strand DNA-binding Protein, ICP-8 (*) (1995) (28)
- Mammalian mitochondrial DNA replication and mechanisms of deletion formation (2020) (28)
- The Herpes Simplex Virus Type 1 Helicase-primase (1998) (26)
- The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication (2021) (23)
- A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL (2018) (22)
- Subnormal levels of POLγA cause inefficient initiation of light-strand DNA synthesis and lead to mitochondrial DNA deletions and progressive external ophthalmoplegia [corrected]. (2013) (20)
- Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing (2020) (20)
- Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria (2019) (18)
- Cloning of the sea urchin mitochondrial RNA polymerase and reconstitution of the transcription termination system (2007) (17)
- mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored. (2012) (17)
- Structural basis for adPEO-causing mutations in the mitochondrial TWINKLE helicase (2018) (16)
- POLRMT mutations impair mitochondrial transcription causing neurological disease (2021) (15)
- Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer (2020) (14)
- Mitochondrial DNA variants in inclusion body myositis characterized by deep sequencing (2020) (11)
- A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma (2017) (10)
- The accessory subunit B of DNA polymerase γ is required for mitochondrial replisome function. (2007) (9)
- Structure Casts Light on mtDNA Replication (2009) (9)
- DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion (2021) (9)
- TWNK in Parkinson's Disease: A Movement Disorder and Mitochondrial Disease Center Perspective Study (2022) (8)
- Deep sequencing of mitochondrial DNA and characterization of a novel POLG mutation in a patient with arPEO (2020) (7)
- The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. (2014) (7)
- Subnormal levels of POLγA cause inefficient initiation of light-strand DNA synthesis and lead to mitochondrial DNA deletions and progressive external ophthalmoplegia (2013) (6)
- Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization (2022) (5)
- The human mitochondrial genome contains a second light strand promoter. (2022) (5)
- An Adaptable High-Throughput Technology Enabling the Identification of Specific Transcription Modulators (2017) (4)
- Unraveling the Structure of a Single DNA During Overstretching Using Multicolor Fluorescence Imaging (2009) (4)
- Subnormal levels of POL g A cause inefficient initiation of light-strand DNA synthesis and lead to mitochondrial DNA deletions and autosomal dominant progressive external ophthalmoplegia (2013) (4)
- Editing the Mitochondrial Genome. (2020) (3)
- Ribonucleotides embedded in template DNA impair mitochondrial RNA polymerase progression (2022) (2)
- Two type I topoisomerases maintain DNA topology in human mitochondria (2022) (2)
- A dual allosteric pathway drives human mitochondrial Lon (2021) (2)
- The role of human DNA glycosylase NEIL 2 and the single-strand break repair protein polynucleotide kinase 3 '-phosphatase in maintenance of the mitochondrial genome (2011) (1)
- Distribution of bombesin-like immunoreactivity in the rat brain and spinal cord (1987) (1)
- Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer (2020) (1)
- Functional analysis of a novel POLγA mutation associated with a severe perinatal mitochondrial encephalomyopathy (2021) (1)
- DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion. (2021) (1)
- Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion (2022) (1)
- Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability. (2023) (0)
- Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions (2019) (0)
- Correction to 'DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion'. (2021) (0)
- Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor. (2020) (0)
- AUTOIMMUNE MYOPATHIES P.303 Mitochondrial DNA rearrangements and point mutations in inclusion body myositis (2020) (0)
- The in vivo role of the mitochondrial DNA nuclease MGME1 (2017) (0)
- In Vitro Analysis of mtDNA Replication. (2021) (0)
- In Vitro Assays of TWINKLE Function. (2023) (0)
- Herpes simplex virus DNA replication : A spacer sequence directs the ATP-dependent formation of a nucleoprotein complex at or S ( UL 9 / ogn-bindlng proten / gel readon / l moblty shlft / cooperativty ) (0)
- Illuminating the DNA Binding Behavior of Mitochondrial Transcription Factor A (2010) (0)
- Topoisomerase 3 alpha is required for decatenation and segregation of human mitochondrial DNA. Nicholls et al. (2017) (0)
- EP.02Deep sequencing of mitochondrial DNA and functional characterization of a novel POLG mutation in a patient with autosomal recessive progressive external ophthalmoplegia (2019) (0)
- Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria (2018) (0)
- In vivo and in vitro mechanistic characterization of a clinically relevant PolγA mutation (2020) (0)
- Topoisomerase 3 α is required for decatenation and segregation of human mitochondrial DNA (2017) (0)
- Abstract 222: Inhibitors of mitochondrial transcription (IMT) specifically affect cancer cell proliferation (2016) (0)
- Disease causing mutation (P178L) in mitochondrial transcription factor A results in impaired mitochondrial transcription initiation. (2022) (0)
- Cell lineage-specific mitochondrial resilience during mammalian organogenesis (2023) (0)
- ight on mt dn A Replication (2009) (0)
- Corrigendum to: Structural basis for adPEO-causing mutations in the mitochondrial TWINKLE helicase (2020) (0)
- Correction to ‘DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion’ (2021) (0)
- loop strands and complete mtDNA replication (2013) (0)
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