Maria de Sousa

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Maria de Sousa is affiliated with the following schools: University of Lisbon, University of Porto, University of Glasgow

Maria de Sousa's AcademicInfluence.com Rankings

Maria de Sousa

Biology

#10031

World Rank

#13312

Historical Rank

Immunology

#817

World Rank

#840

Historical Rank

biology Degrees

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Biology

Maria de Sousa's Degrees

Doctorate Medicine University of Lisbon

Why Is Maria de Sousa Influential?

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According to Wikipedia, Maria Ângela Brito de Sousa was a Portuguese immunologist, science leader poet and writer. She gained international recognition as a medical researcher, as the author of several seminal scientific papers: she was the first to describe thymus-dependent areas in 1966, a fundamental discovery in the mapping of peripheral lymphoid organs; she coined the term "ecotaxis" in 1971, to describe the phenomenon of cells of different origins to migrate and to organize among themselves in very specific lymphoid areas. In the 1980s she focused on the study of hereditary hemochromatosis, an iron overload genetic disease.

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Maria de Sousa's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

THYMUS-DEPENDENT AREAS IN THE LYMPHOID ORGANS OF NEONATALLY THYMECTOMIZED MICE (1966) (490)
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers (2020) (475)
Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. (2006) (319)
World J Gastroenterol (2010) (258)
Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man (1996) (193)
Chemical Chaperones Reduce Endoplasmic Reticulum Stress and Prevent Mutant HFE Aggregate Formation* (2007) (170)
Iron overload in β2-microglobulin-deficient mice (1994) (167)
Thymus-dependent and thymus-independent populations: origin, migratory patterns and lifespan. (1971) (158)
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia. (2008) (152)
Calreticulin Is Expressed on the Cell Surface of Activated Human Peripheral Blood T Lymphocytes in Association with Major Histocompatibility Complex Class I Molecules* (1999) (144)
The lymphoid tissues in mice with congenital aplasia of the thymus. (1969) (143)
Iron overload and immunity. (2007) (130)
Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation. (2002) (111)
Transferrin and the transferrin receptor: of magic bullets and other concerns. (2008) (96)
Melanoma vaccines. (1998) (84)
Ferritin synthesis by human T lymphocytes. (1980) (81)
Phylogeny of the lymphoid system. I. A study of the fate of circulating lymphocytes in plaice (1974) (76)
Effect of transfusional iron overload on immune response. (2000) (75)
Haemochromatosis as a window into the study of the immunological system: A novel correlation between CD8+ lymphocytes and iron overload (1994) (73)
Disproportionate lymphoid cell subsets in thalassaemia major: the relative contributions of transfusion and splenectomy (1985) (72)
Anomalies of the CD8+ T cell pool in haemochromatosis: HLA‐A3‐linked expansions of CD8+CD28− T cells (1997) (71)
HFE cross-talks with the MHC class I antigen presentation pathway. (2005) (67)
The lymphoid organs during pregnancy in the mouse. A comparison between a syngeneic and an allogeneic mating. (1973) (67)
Stimulation of an Unfolded Protein Response Impairs MHC Class I Expression1 (2007) (67)
Immune cell functions in iron overload. (1989) (66)
Anti-TNF-alpha treatment down-regulates the expression of fibronectin and decreases cellular infiltration of cardiac allografts in rats. (1995) (62)
Hepcidin messenger RNA expression in human lymphocytes (2010) (61)
Induction and recall in contact sensivitity. Changes in skin and draining lymph nodes of intact and thymectomized mice. (1969) (61)
Decreased natural killer activity in thalassemia major: a possible consequence of iron overload. (1986) (61)
Ontogeny of B and T cells in sea bass (Dicentrarchus labrax, L.). (2000) (61)
Iron in immunity, cancer and inflammation (1989) (60)
T cell numbers relate to bone involvement in Gaucher disease. (1999) (56)
Transferrin is required for early T‐cell differentiation (2004) (54)
Kinetics of the distribution of thymus and marrow cells in the peripheral lymphoid organs of the mouse: ecotaxis. (1971) (54)
Decreased CD8‐p561ck Activity in Peripheral Blood T‐Lymphocytes from Patients with Hereditary Haemochromatosis (1994) (52)
Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis. (2011) (52)
Differential effects of eight metal ions on lymphocyte differentiation antigens in vitro. (1990) (50)
Iron, Iron‐binding Proteins and Immune System Cells a (1988) (49)
The cellular basis of immunological recovery in nude mice after thymus grafting. (1974) (47)
Lymphoid Cell Sets and Serum Immunoglobulins in Patients with Thalassaemia Intermedia: Relationship to Serum Iron and Splenectomy (1980) (47)
Defective iron homeostasis in β2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man (1997) (47)
Control mechanisms of lymphocyte traffic. Modification of the traffic of 51 Cr‐Labeled mouse lymph node cells by treatment with plant lectins in intact and splenectomized hosts (1975) (46)
Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1. (2000) (46)
Comparative study of the two more frequent HFE mutations (C282Y and H63D): significant different allelic frequencies between the North and South of Portugal (2001) (45)
Ecotaxis: the principle and its application to the study of Hodgkin's disease. (1977) (43)
Molecular analysis of iron overload in beta2-microglobulin-deficient mice. (2004) (43)
Regulation of expression of a human lymphoid cell surface marker by iron. (1980) (42)
Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2-microglobulin knockout mice. (1998) (42)
Lymphocyte circulation : experimental and clinical aspects (1981) (41)
Characterisation of monoclonal antibodies specific for sea bass (Dicentrarchus labraxL.) IgM indicates the existence of B cell subpopulations (1997) (39)
Lymphocyte traffic is modified in vivo by anti-laminin antibody. (1991) (39)
Iron and Lymphocytes: Reciprocal Regulatory Interactions1 (1991) (38)
Iron Binding Proteins in Selected Human Peripheral Blood Cell Sets: Immunofluorescence (1980) (37)
Inhibition of E-rosette formation by two iron salts. (1978) (36)
Malignant changes in New Zealand black mice. (1967) (33)
Circannual rhythm in natural killer activity and mitogen responsiveness of murine splenocytes. (1987) (33)
Consequences of neonatal thymectomy in New Zealand black mice. (1967) (32)
Haemocytes in Cerastoderma edule (Mollusca, Bivalvia): distinct cell types engage in different responses to sheep erythrocytes (1994) (32)
Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome. (2015) (31)
Increased hepatic iron in mice lacking classical MHC class I molecules. (2002) (30)
Control mechanism of lymphocyte traffic. A study of the action of two sulfated polysaccharides on the distribution of 51Cr- and [3H]adenosine-labeled mouse lymph node cells. (1977) (29)
The role of cell interactions in the control of lymphocyte traffic. (1976) (28)
Association of Serum Iron, Serum Transferrin Saturation, and Serum Ferritin with Survival in Acute Lymphocytic Leukemia (1987) (27)
The response of normal, thymectomized and reconstituted mice in contact sensitivity. (1970) (27)
In vivo localization of cloned IL-2-dependent T cells. (1983) (27)
Microcirculation of the lymph node with metastases. (1976) (26)
Collagen arthritis in the rat is initiated by CD4+ T cells and can be amplified by iron. (1989) (26)
In vitro modulation of T-cell surface molecules by iron. (1994) (26)
Lymphocyte interactions and positioning. I. Adhesive interactions. (1975) (24)
Fibronectin in Immune Responses in Organ Transplant Recipients (2000) (22)
The cellular basis of the mechanism of action of cortisone acetate on contact sensitivity to oxazolone in the mouse. (1972) (22)
Hemochromatosis: Variation of hemochromatosis prevalence and genotype in national groups (2000) (22)
Comparative study between Hfe‐/‐ and β2m‐/‐ mice: progression with age of iron status and liver pathology (2006) (21)
Activation of rat synovium by iron. (1988) (21)
ER Stress and Iron Homeostasis: A New Frontier for the UPR (2010) (21)
Lymphoid cell positioning: a new proposal for the mechanism of control of lymphoid cell migration. (1978) (20)
Control mechanism of lymphocyte traffic Altered migration of 51Cr‐labeled mouse lymph node cells pretreated in vitro with phospholipases (1976) (20)
Expansions of CD8+CD28- and CD8+TcRVbeta5.2+ T cells in peripheral blood of heavy alcohol drinkers. (2000) (20)
The persistence of donor-derived cells in thymus grafts, lymph nodes and spleens of recipient mice. (1967) (20)
Ferritin secretion by human mononuclear cells: association with HLA phenotype. (1983) (20)
CHARACTERIZATION OF ASPHALTENE PARTICLES BY LIGHT SCATTERING AND ELECTROPHORESIS (2001) (19)
Kinetics of the distribution of thymus and marrow cells in the peripheral lymphoid organs of the mouse: ecotaxis. (1971) (19)
Protective role of calreticulin in HFE hemochromatosis (2008) (19)
Cobalt-chromium-molybdenum but not titanium-6aluminium-4vanadium alloy discs inhibit human t cell activation in vitro (1996) (19)
Differential inhibitory effect of iron on E, EA, and EAC rosette formation. (1979) (17)
Ecology of Thymus Dependency (1973) (17)
Relative subunit composition of the ferritin synthesized by selected human lymphomyeloid cell populations. (1983) (16)
T lymphocytes and iron overload: novel correlations of possible significance to the biology of the immunological system (1992) (16)
BLOOD TRANSFUSIONS AND ALLOGRAFT SURVIVAL: IRON-RELATED IMMUNOSUPPRESSION? (1983) (14)
Overexpression of HFE in HepG2 cells reveals differences in intracellular distribution and co-localization of wt- and mutated forms. (2007) (13)
Immunologic Parameters in Childhood Hodgkin's Disease II. T and B Lymphocytes in the Peripheral Blood of Normal Children and in the Spleen and Peripheral Blood of Children with Hodgkin's Disease (1978) (13)
Iron differentially modulates the CD4-lck and CD8-lck complexes in resting peripheral blood T-lymphocytes. (1995) (13)
The role of cellular and extracellular matrix adhesion proteins in organ transplantation. (1994) (13)
Hemochromatosis: T-lymphocyte expression and function in hemochromatosis (2000) (13)
In vitro responses of peripheral blood and spleen lymphoid cells to mitogens and antigens in childhood Hodgkin's disease. (1978) (13)
Adhesion molecule interaction with extracellular matrix. (1993) (12)
Low serum transferrin levels in HFE C282Y homozygous subjects are associated with low CD8(+) T lymphocyte numbers. (2005) (12)
Proteins of the Metabolism of Iron, Cells of the Immune System and Malignancy (1984) (12)
Lymphocyte Traffic and Positioning in Vivo: An Expande Role for the ECM, the VLA Proteins and the Cytokines (1994) (12)
Ecotaxis, Ecotaxopathy, and Lymphoid Malignancy: Terms, Facts, and Predictions (1978) (11)
The unfolded protein response in hereditary haemochromatosis. (2008) (11)
Ferritin in neuroblastoma. Impact of tumor load and blood transfusions. (1985) (11)
Differential inhibition of the MLR by iron: Association with HLA phenotype (2005) (10)
INDUCTION AND RECALL IN CONTACT SENSITIVITY (1969) (10)
Iron exerts a specific inhibitory effect on CD2 expression of human PBL. (1988) (10)
Multidrug resistance protein 4 (MRP4/ABCC4) is overexpressed in clear cell renal cell carcinoma (ccRCC) and is essential to regulate cell proliferation. (2020) (9)
HFE mutations in the pathobiology of hemophilic arthropathy. (2005) (9)
Spleen cell populations in Hodgkin's disease. (1979) (9)
An Initial Model of Scarcity (2016) (8)
T- and B-Cell Populations in Gut and Gut-Associated Lymphoid Organs: Arrangement, Migration, and Function (1978) (8)
Migratory patterns of the Ly subsets of T lymphocytes in the mouse. (1979) (8)
HFE Related Hemochromatosis: Uncovering the Inextricable Link between Iron Homeostasis and the Immunological System (2019) (8)
Regulation of intracellular iron levels in iron-acceptor and iron-donor cells. (2000) (7)
Imaging of lymphoid structures with indium-111-labeled lymphocytes. (1983) (7)
Divergent actions of monomeric, dimeric, and tetrameric concanavalin A on lymphocyte traffic. (1978) (7)
Lyt phenotype, lymphocyte migration and the selective tissue positioning of mouse T cell sets. (1984) (7)
Iron compounds after erythrophagocytosis: chemical characterization and immunomodulatory effects. (1997) (7)
Characterization of rat spleen-cell populations. I. Cell interactions in the regulation of in vitro response to concanavalin A. (1979) (6)
Ecotaxis of B cells in the mouse. (1973) (6)
Characterization of IL-2-dependent cytotoxic T-cell clones. II. Cell-surface phenotypes, histochemical and ultrastructural properties. (1983) (6)
Evaluation of indium-111 chloride as a radiopharmaceutical for joint imaging in a rabbit model of arthritis. (1987) (6)
The distribution of iron and iron binding proteins in spleen with reference to Hodgkin's disease. (1986) (6)
Control mechanism of lymphocyte traffic. Altered distribution of 51Cr‐labeled mouse lymph node cells pretreated in vitro with lipopolysaccharide (1976) (5)
Lyt phenotype and lectin binding properties of mouse lymphocytes which enter lymph nodes. (1982) (5)
Factors affecting the traffic and segregation of lymphoid cell populations. (1973) (4)
Thymus cell differentiation and in vivo T-cell migration. I. Migration of lectin-selected thymocytes. (1983) (4)
Microenvironment to a lymphoid cell is nothing more than interaction with its neighbours. (1976) (4)
An outsider's perspective--ecotaxis revisited: an integrative review of cancer environment, iron and immune system cells. (2011) (4)
Enhancement of T lymphocyte differentiation in vitro by thymic extracts and purified polypeptides in severe combined immunodeficiency diseases. (1975) (4)
Iron‐induced Changes in T Cell Populations in Rat Synovium a (1988) (4)
Modulation of B-cell interactions by T cells (1976) (4)
REGULATORY INFLUENCE OF THYMOPENTIN ON SPLENIC T CELL SETS OF THYMECTOMIZED AND AGED MICE1,2 (1985) (4)
Distribution and mechanism of uptake of 111InCl3 in a tumor model for lymph node metastases. (1985) (4)
An outsider's perspective--ecotaxis revisited: an integrative review of cancer environment, iron and immune system cells. (2011) (4)
Iron Compounds after Erythrophagocytosis: Chemical Characterization and Immunomodulatory Effects (1998) (3)
Postbreast cancer surgery outpatient rehabilitation program: Analysis of clinical profile, impact, and direct medical costs (2019) (3)
Potential Therapeutic Applications of Jak2 Inhibitors in Beta-Thalassemia and Sickle Cell Disease, (2011) (3)
Potential of indium-111 to measure inflammatory arthritis. (1986) (3)
Hereditary Hemochromatosis (HH) in the North of Portugal (1988) (3)
Lymphocyte migration and tissue positioning in allograft reciepients: The role played by extracellular matrix proteins* (1995) (3)
Iron, Iron Genes, and the Immune System (2005) (3)
Anomalies of the CD8+ T cell pool in hereditary hemochromatosis: HLA-A3 linked expansions of CD28− T cells (1997) (3)
Distinguishing features of the immunology of Hodgkin's disease in children. (1982) (2)
Microenvironment to a Lymphoid Cell is nothing more than Interaction with its Neighbours (1976) (2)
Correlation of immunogenetic and histological changes in immuno-deficient mutant hr/hr mice. (1979) (2)
Absence of the Hemochromatosis Gene Hfe Confers Protection Under Conditions of Stress Erythropoiesis. (2008) (2)
Differential effect of two monoclonal anti-Lyt-1 alloantibodies on lymphocyte distribution in vivo. (1984) (2)
The Side Effects of High Zone Tolerance (1971) (2)
Spleen lymphocyte populations in patients with Hodgkin's disease--properties of cells with different densities. (1982) (2)
Hepcidin: a clue for a new role for lymphocytes (2010) (1)
A personal account of the development of modern biological research in Portugal. (2009) (1)
A personal account of the development of modern biological research in Portugal. (2009) (1)
Accelerated Proliferation and Limited Differentiation, Mediated through Jak2, Exacerbate Ineffective Erythropoiesis in β-Thalassemia. (2007) (1)
Hydroxyapatite Surface Coatings for Biomaterials: A Report of a Multi-Centre Investigation–Brite-Euram Project BREU/0172C (1994) (1)
Iron and the Immune System (2012) (1)
Hemochromatosis: β2-microglobulin-deficient mice as a model for hemochromatosis (2000) (1)
HFE crosstalks with the MHC class I antigen presentation pathway Running title: The antigen presentation in HFE C282Y mutant cells (2016) (1)
Macrophage Depletion Leads to Modification of Thalassemic Phenotype. (2009) (1)
A role for the immunological system in iron homeostasis: ‘But how?’ (2008) (0)
The Portuguese in European Immunology (2000) (0)
Imaginative immunology (1977) (0)
Circulation and Distribution of Iron (2020) (0)
erythropoiesis in Decreased differentiation of erythroid cells exacerbates ineffective (2008) (0)
Association of HLA phenotype with individual variations in ferritin secretion by activated human mononuclear cells (1982) (0)
Expression of Ferritin Messenger RNA in an in vitro Model of Human CD3-Mediated T-Lymphocyte Activation (1991) (0)
Hepcidin: A Clue for a New Role for Lymphocytes. (2009) (0)
Immunopathology of M. lepremurium (MLM) infection in B6 C3AN and (C3HxB6) F1 mice. (1979) (0)
MHC class-I associations in iron overload: new link between the H63D mutation, HLA-A29 and “non-classical” haemochromatosis (1998) (0)
Clinically Significant Correlations between Blood Transfusions, Ferritin and Prognosis in Neuroblastoma (1985) (0)
IMAGING OF LYMPHOID STRUCTURES WITH 111In LABELLED LYMPHOCYTES (1981) (0)
Role of HFE in Hepatic Iron Overload: Novel Findings Demonstrate Direct Effects of Mutant C282Y on Hepcidin and Calreticulin mRNA Expression. (2006) (0)
EFIS: the growing danger of self-satisfaction with numbers. (1993) (0)
Adaptive Response of Iron Absorption to Anemia, Increased Erythropoiesis, Iron Deﬁciency, and Iron Loading in (cid:98) 2-Microglobulin Knockout Mice (1998) (0)
Lymphocyte Maldistribution and Immunodeficiency (1980) (0)
Lymphocyte traffic ismodified invivobyanti-laminin antibody (1990) (0)
Lymph Node Response to Antigen-Antibody Complexes and the Fate of Injected Primed Lymphocytes in a Tolerant Host (1971) (0)
Voltage-clamp: a useful approach to study in vitro duodenal iron transport in the mouse (2000) (0)
Hereditary Hemochromatosis (HH) in the North of Portugal (1988) (0)
Sex-related Differences in Tumor Progression Associated with Altered Lymphocyte Circulation 1 (2004) (0)
In vivo migration of cloned il-2 dependent cytotoxic t cells. Abstr. (1982) (0)
Obituary (1983) (0)
The Distribution of Ferritin and Ferric Iron in the Spleens of Lymphoma Patients and Controls (1985) (0)
iron overload: identification of a novel TfR2 mutation Transferrin receptor 2 (TfR2) and HFEmutational analysis in non-C282Y (2013) (0)
T-cell-receptor repertoire abnormalities in hemochromatosis (1997) (0)
Ecotaxis: theprinciple andits application tothestudy of Hodgkin's disease (1977) (0)
Potential Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Reverse Splenomegaly in β-Thalassemia. (2008) (0)
Clinical heterogeneity in genetic hemochromatosis: Relative impact of HLA and CD4/CD8 ratios (1997) (0)
TUMOR IMAGING WITH INDIUM CHLORIDE (1983) (0)
SUPPRESSION OF LYMPHOCYTE TRANSFORMATION BY SERA FROM PATIENTS WITH ALCOHOLIC LIVER DISEASE (1980) (0)
Defect of Ferritin Secretion in HLA-A3 Subjects and in Idiopathic Hemochromatosis (1984) (0)
Knockout Mice 2-Microglobulin β Erythropoiesis, Iron Deficiency, and Iron Loading in Adaptive Response of Iron Absorption to Anemia, Increased (2013) (0)
BROXMEYER , BOGNACKI , DORNER , AND DE SOUSA 1427 with leukemia and from BALB / c mice infected with Abelson virus and mice infected with Friend (2003) (0)
[Spleen lymphocyte subpopulations in patients with Hodgkin's disease]. (1979) (0)
ß-Thalassemic Mice Require Functional Hfe to Modulate Hepcidin Expression In Response to Iron Overload (2010) (0)
CD8+ cells in liver and expression of hereditary haemochromatosis (HH) (1998) (0)
Expansions of CD8+CD28− T lymphocytes in chronic alcohol intake: Influence of HLA-H (1997) (0)
Impairs MHC Class I Expression Stimulation of an Unfolded Protein Response (2007) (0)
On the 20th anniversary of a scientific discovery. (1979) (0)
HLA-H mutations and protection for alcohol induced liver injury: A process mediated by T lymphocytes? (1997) (0)
Hfe Modulates the Response to Erythopoietic Stress In Wt Mice by Two Distinct Mechanisms (2010) (0)

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What Schools Are Affiliated With Maria de Sousa?

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