Marilyn Kozak
Professor of Biochemistry
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Biology
Why Is Marilyn Kozak Influential?
(Suggest an Edit or Addition)According to Wikipedia, Marilyn S. Kozak is an American professor of biochemistry at the Robert Wood Johnson Medical School. She was previously at the University of Medicine and Dentistry of New Jersey before the school was merged. She was awarded a PhD in microbiology by Johns Hopkins University studying the synthesis of the Bacteriophage MS2, advised by Daniel Nathans. In her original faculty job proposal, she sought to study the mechanism of eukaryotic translation initiation, a problem long thought to have already been solved by Joan Steitz. While in the Department of Biological Sciences at University of Pittsburgh, she published a series of studies that established the scanning model of translation initiation and the Kozak consensus sequence. Her current research interests are unknown as her last publication was in 2008.
Marilyn Kozak's Published Works
Published Works
- An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. (1987) (4705)
- Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes (1986) (4264)
- The scanning model for translation: an update (1989) (3183)
- Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. (1984) (2666)
- Structural features in eukaryotic mRNAs that modulate the initiation of translation. (1991) (1759)
- An analysis of vertebrate mRNA sequences: intimations of translational control (1991) (1601)
- Initiation of translation in prokaryotes and eukaryotes. (1999) (1408)
- At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. (1987) (1158)
- Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. (1981) (1060)
- Pushing the limits of the scanning mechanism for initiation of translation (2002) (868)
- Regulation of translation via mRNA structure in prokaryotes and eukaryotes. (2005) (727)
- How do eucaryotic ribosomes select initiation regions in messenger RNA? (1978) (686)
- Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs (1989) (611)
- Influences of mRNA secondary structure on initiation by eukaryotic ribosomes. (1986) (592)
- Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes. (1987) (536)
- Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes. (1990) (511)
- Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6 (1997) (499)
- Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems (1989) (476)
- Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo (1984) (442)
- Regulation of translation in eukaryotic systems. (1992) (390)
- Bifunctional messenger RNAs in eukaryotes (1986) (350)
- Selection of initiation sites by eucaryotic ribosomes: effect of inserting AUG triplets upstream from the coding sequence for preproinsulin. (1984) (348)
- Constraints on reinitiation of translation in mammals. (2001) (281)
- Adherence to the first-AUG rule when a second AUG codon follows closely upon the first. (1995) (259)
- A short leader sequence impairs the fidelity of initiation by eukaryotic ribosomes. (1991) (193)
- Evaluation of the “scanning model” for initiation of protein synthesis in eucaryotes (1980) (193)
- Migration of 40 S ribosomal subunits on messenger RNA in the presence of edeine. (1978) (180)
- A second look at cellular mRNA sequences said to function as internal ribosome entry sites (2005) (174)
- Influence of mRNA secondary structure on binding and migration of 40S ribosomal subunits (1980) (147)
- Leader length and secondary structure modulate mRNA function under conditions of stress (1988) (139)
- New Ways of Initiating Translation in Eukaryotes? (2001) (137)
- Effects of long 5' leader sequences on initiation by eukaryotic ribosomes in vitro. (1991) (135)
- Regulation of Protein Synthesis in Virus-Infected Animal Cells (1986) (132)
- Interpreting cDNA sequences: Some insights from studies on translation (1996) (129)
- Role of ATP in binding and migration of 40S ribosomal subunits (1980) (127)
- Determinants of translational fidelity and efficiency in vertebrate mRNAs (1994) (127)
- Inability of circular mRNA to attach to eukaryotic ribosomes (1979) (124)
- A consideration of alternative models for the initiation of translation in eukaryotes. (1992) (124)
- Emerging links between initiation of translation and human diseases (2002) (108)
- Alternative ways to think about mRNA sequences and proteins that appear to promote internal initiation of translation. (2003) (104)
- Identification of features in 5′ terminal fragments from reovirus mRNA which are important for ribosome binding (1978) (102)
- Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI. (1997) (102)
- Translation of insulin-related polypeptides from messenger RNAs with tandemly reiterated copies of the ribosome binding site (1983) (90)
- Nucleotide sequences of 5′-terminal ribosome-protected initiation regions from two reovirus messages (1977) (86)
- A profusion of controls (1988) (84)
- Primer extension analysis of eukaryotic ribosome-mRNA complexes. (1998) (74)
- Characterization of ribosome-protected fragments from reovirus messenger RNA. (1976) (71)
- Features in the 5′ non-coding sequences of rabbit α and β-globin mRNAs that affect translational efficiency (1994) (71)
- Evaluation of the fidelity of initiation of translation in reticulocyte lysates from commercial sources. (1990) (67)
- Sequences of two 5'-terminal ribosome-protected fragments from reovirus messenger RNAs. (1977) (66)
- Do the 5'untranslated domains of human cDNAs challenge the rules for initiation of translation (or is it vice versa)? (2000) (64)
- Sequences and properties of two ribosome binding sites from the small size class of reovirus messenger RNA. (1977) (61)
- Some thoughts about translational regulation: Forward and backward glances (2007) (50)
- How strong is the case for regulation of the initiation step of translation by elements at the 3' end of eukaryotic mRNAs? (2004) (50)
- Faulty old ideas about translational regulation paved the way for current confusion about how microRNAs function. (2008) (50)
- Biochemical Aspects of Reovirus Transcription and Translation (1983) (46)
- Migration of 40 S ribosomal subunits on messenger RNA when initiation is perturbed by lowering magnesium or adding drugs. (1979) (46)
- Features in the 5' non-coding sequences of rabbit alpha and beta-globin mRNAs that affect translational efficiency. (1994) (38)
- Analysis of ribosome binding sites from the s1 message of reovirus. Initiation at the first and second AUG codons. (1982) (37)
- Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles (1983) (37)
- Rethinking some mechanisms invoked to explain translational regulation in eukaryotes. (2006) (33)
- Structures of two highly homologous bacterial L-asparaginases: a case of enantiomorphic space groups. (2001) (26)
- Lessons (not) learned from mistakes about translation. (2007) (25)
- STUDIES ON THE PATHOGENESIS OF FEVER (1968) (25)
- Characterization of translational initiation regions from eukaryotic messenger RNAs. (1979) (23)
- Not every polymorphism close to the AUG codon can be explained by invoking context effects on initiation of translation. (2003) (21)
- Binding of wheat germ ribosomes to fragmented viral mRNA (1980) (21)
- Binding of wheat germ ribosomes to bisulfite-modified reovirus messenger RNA: evidence for a scanning mechanism. (1980) (21)
- How do eukaryotic ribosomes recognize the unique AUG initiator codon in messenger RNA? (1982) (13)
- Extensively overlapping reading frames in a second mammalian gene (2001) (13)
- Sequences of ribosome binding sites from the large size class of reovirus mRNA (1982) (11)
- A Progress Report on Translational Control in Eukaryotes (2001) (10)
- Recognition of Initiation Sites in Eukaryotic Messenger RNAs (1982) (5)
- Adherence to the first-AUG rule when a second AUG codon follows closely upon the first. (1995) (5)
- International Symposium on Protein Synthesisに出席して (1977) (3)
- Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes (1987) (2)
- Translation of the genome of a ribonucleic acid bacteriophage (1972) (2)
- A Short Review of Scanning (1990) (1)
- 5′-TERMINAL CAPS IN EUKARYOTIC mRNAS (1979) (1)
- 5′-TERMINAL 7-METHYLGUANOSINE IN VIRAL mRNAs AND ITS ROLE IN TRANSLATION (1976) (1)
- Interaction of Eukaryotic Ribosomes with Messenger RNA: Evidence for a Scanning Mechanism (1981) (0)
- Marilyn Kozak Eukaryotes ? New Ways of Initiating Translation in (2001) (0)
- Leader LengthandSecondary Structure Modulate mRNA Function underConditions ofStress (1988) (0)
- Biochemical polymorphism of protein fractions in canine blood serum. (2000) (0)
- Erratum to “Alternative ways to think about mRNA sequences and proteins that appear to promote internal initiation of translation” [Gene 318 (2003) 1–23] (2004) (0)
- Translational regulation in mammalian cells (2003) (0)
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