Mark A. Smith
#23,715
Most Influential Person Now
American neuroscientist and Alzheimer researcher
Mark A. Smith's AcademicInfluence.com Rankings
Mark A. Smithbiology Degrees
Biology
#1279
World Rank
#2171
Historical Rank
#650
USA Rank
Neuroscience
#354
World Rank
#371
Historical Rank
#124
USA Rank

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Biology
Mark A. Smith's Degrees
- PhD Neuroscience Stanford University
Why Is Mark A. Smith Influential?
(Suggest an Edit or Addition)According to Wikipedia, Mark Anthony Smith was a professor of pathology at Case Western Reserve University in Cleveland, Ohio, where he also served as the Director of Basic Science Research at the University Memory and Aging Center. At the time of his death, he had been serving as Executive Director of the American Aging Association.
Mark A. Smith's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008) (2360)
- Alzheimer disease. (2010) (1859)
- Oxidative Damage Is the Earliest Event in Alzheimer Disease (2001) (1811)
- Mitochondrial abnormalities in Alzheimer disease (2000) (1275)
- Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease (1997) (1246)
- 4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease (1997) (990)
- Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease (2009) (981)
- Oxidative stress and neurotoxicity. (2008) (740)
- RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease (1999) (721)
- Drosophila Fragile X-Related Gene Regulates the MAP1B Homolog Futsch to Control Synaptic Structure and Function (2001) (656)
- Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. (2010) (610)
- Involvement of Oxidative Stress in Alzheimer Disease (2006) (556)
- Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress (1998) (553)
- Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. (2005) (548)
- Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence. (2003) (525)
- In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease (2000) (512)
- Radical AGEing in Alzheimer's disease (1995) (475)
- Oxidative stress in Alzheimer disease: A possibility for prevention (2010) (446)
- Alzheimer's disease: the two-hit hypothesis (2004) (417)
- Alzheimer Disease and Oxidative Stress (2002) (414)
- Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide (1995) (414)
- Activation and redistribution of c‐Jun N‐terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease (2001) (409)
- Oxidative stress signalling in Alzheimer's disease (2004) (393)
- Oxidative Stress Increases Expression and Activity of BACE in NT2 Neurons (2002) (368)
- Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc* (2000) (361)
- Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. (2010) (350)
- Activation of p38 Kinase Links Tau Phosphorylation, Oxidative Stress, and Cell Cycle‐Related Events in Alzheimer Disease (2000) (345)
- The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s Disease (2002) (345)
- Role of mitochondrial dysfunction in Alzheimer's disease (2002) (344)
- Redox-active iron mediates amyloid-β toxicity (2001) (340)
- Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta. (2004) (320)
- Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease (2003) (316)
- Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis (2001) (302)
- Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? (2002) (302)
- Oxidative Stress and Neurodegeneration (2005) (300)
- Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. (2003) (290)
- Oxidative stress activates a positive feedback between the γ‐ and β‐secretase cleavages of the β‐amyloid precursor protein (2007) (283)
- Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-term Blueberry Supplementation in Aged Rats (2004) (283)
- Microglial activation and amyloid‐β clearance induced by exogenous heat‐shock proteins (2002) (279)
- Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy (2002) (279)
- Alzheimer disease, the two-hit hypothesis: an update. (2007) (274)
- Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron* (2005) (270)
- Role of metal dyshomeostasis in Alzheimer's disease. (2011) (265)
- The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease (2009) (257)
- Mitochondria: a therapeutic target in neurodegeneration. (2010) (253)
- Abnormal mitochondrial dynamics and neurodegenerative diseases. (2010) (252)
- Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease (1998) (246)
- Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion (2011) (243)
- Oxidative stress in diabetes and Alzheimer's disease. (2009) (243)
- Tau phosphorylation in Alzheimer's disease: pathogen or protector? (2005) (232)
- Cytochemical Demonstration of Oxidative Damage in Alzheimer Disease by Immunochemical Enhancement of the Carbonyl Reaction with 2,4-Dinitrophenylhydrazine (1998) (230)
- Carbonyl‐Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's Disease (1995) (227)
- Diabetes‐induced nitrative stress in the retina, and correction by aminoguanidine (2002) (221)
- Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. (2010) (209)
- Oxidative Stress and Redox‐Active Iron in Alzheimer's Disease (2004) (207)
- Copernicus revisited: amyloid beta in Alzheimer’s disease (2001) (202)
- Identification of Ubiquilin, a Novel Presenilin Interactor That Increases Presenilin Protein Accumulation (2000) (201)
- In Alzheimer's Disease, Heme Oxygenase Is Coincident with Alz50, an Epitope of τ Induced by 4‐Hydroxy‐2‐Nonenal Modification (2000) (200)
- A zyxin-mediated mechanism for actin stress fiber maintenance and repair. (2010) (200)
- Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease? (2011) (198)
- Nucleic acid oxidation in Alzheimer disease. (2008) (196)
- Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. (2012) (195)
- The up‐regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α (2009) (193)
- Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease (2012) (191)
- Overexpression of Heme Oxygenase in Neuronal Cells, the Possible Interaction with Tau* (2000) (190)
- Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein. (2008) (187)
- Active glycation in neurofibrillary pathology of Alzheimer disease: Nε-(Carboxymethyl) lysine and hexitol-lysine (2001) (186)
- Reactive Oxygen Species Mediate Cellular Damage in Alzheimer Disease. (1998) (186)
- Iron: The Redox-active Center of Oxidative Stress in Alzheimer Disease (2007) (184)
- Challenging the Amyloid Cascade Hypothesis: Senile Plaques and Amyloid‐β as Protective Adaptations to Alzheimer Disease (2004) (183)
- Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein (2001) (182)
- Vascular oxidative stress in Alzheimer disease (2007) (180)
- Tau – an inhibitor of deacetylase HDAC6 function (2009) (179)
- Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain (2002) (176)
- Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice. (2006) (176)
- The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations (2011) (175)
- From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8). (2008) (175)
- Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease. (2006) (173)
- The Role of Oxidative Stress in the Pathophysiology of Cerebrovascular Lesions in Alzheimer's Disease (2002) (173)
- Abnormal localization of iron regulatory protein in Alzheimer's disease (1998) (172)
- Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron. (2007) (171)
- Alzheimer Disease Pathology As a Host Response (2008) (168)
- Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. (2007) (168)
- Faculty of 1000 evaluation for Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. (2012) (167)
- Subcellular and metabolic examination of amyloid-β peptides in Alzheimer disease pathogenesis: Evidence for Aβ25–35 (2010) (163)
- Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans (2002) (163)
- Nanoparticle iron chelators: A new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance (2006) (163)
- Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. (2007) (159)
- Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe? (2003) (158)
- Oxidative Damage to RNA in Aging and Neurodegenerative Disorders (2012) (157)
- Abortive apoptosis in Alzheimer's disease (2001) (156)
- Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage. (2007) (155)
- Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection. (2009) (155)
- Alzheimer disease and the role of free radicals in the pathogenesis of the disease. (2008) (154)
- Insulin is a two-edged knife on the brain. (2009) (154)
- Metal ions and oxidative protein modification in neurological disease. (2005) (153)
- Hippocampal vulnerability to stress and aging: possible role of neurotrophic factors (1996) (153)
- Advanced Maillard Reaction End Products, Free Radicals, and Protein Oxidation in Alzheimer's Disease a (1994) (153)
- 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. (2005) (153)
- Premenopausal bone loss in the lumbar spine and neck of femur: a study of 225 Caucasian women. (1990) (151)
- RNA oxidation in Alzheimer disease and related neurodegenerative disorders (2009) (151)
- LIPID PEROXIDATION AND PROTEIN OXIDATION IN ALZHEIMER'S DISEASE BRAIN: POTENTIAL CAUSES AND CONSEQUENCES INVOLVING AMYLOID -PEPTIDE-ASSOCIATED FREE RADICAL OXIDATIVE STRESS (2002) (149)
- Total body calcium in rheumatoid arthritis: effects of disease activity and corticosteroid treatment. (1982) (149)
- Antioxidant therapy in Alzheimer's disease: theory and practice. (2008) (149)
- Corticosteroids and bone mass in asthma: comparisons with rheumatoid arthritis and polymyalgia rheumatica. (1986) (148)
- AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation (2012) (147)
- Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking. (2005) (146)
- Activation of MKK6, an upstream activator of p38, in Alzheimer's disease (2001) (145)
- Senile plaque composition and posttranslational modification of amyloid-β peptide and associated proteins (2002) (144)
- Increased Autophagic Degradation of Mitochondria in Alzheimer Disease (2007) (142)
- Amyloid-β in Alzheimer Disease: The Null versus the Alternate Hypotheses (2007) (142)
- Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells (2010) (140)
- A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease. (2010) (140)
- Oxidative imbalance in alzheimer’s disease (2007) (140)
- Nanoparticle and other metal chelation therapeutics in Alzheimer disease. (2005) (139)
- Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease. (2013) (138)
- Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. (2002) (138)
- Iron: A Pathological Mediator of Alzheimer Disease? (2002) (138)
- Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease (2009) (136)
- Nanoparticle–chelator conjugates as inhibitors of amyloid-β aggregation and neurotoxicity: A novel therapeutic approach for Alzheimer disease (2009) (135)
- Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material. (2008) (135)
- Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease (2004) (135)
- Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta. (2009) (133)
- Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes (2008) (132)
- Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. (2005) (131)
- Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells (2003) (131)
- Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease (2008) (130)
- Neuropathology of Alzheimer disease: pathognomonic but not pathogenic (2006) (128)
- Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. (2008) (128)
- High Molecular Weight Neurofilament Proteins Are Physiological Substrates of Adduction by the Lipid Peroxidation Product Hydroxynonenal* (2002) (127)
- Cl−-ATPase and Na+/K+-ATPase activities in Alzheimer's disease brains (1998) (127)
- Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats (2008) (126)
- Introduction of fast MR imaging in the assessment of hepatic steatosis (1997) (126)
- Leptin: a novel therapeutic strategy for Alzheimer's disease. (2009) (124)
- Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. (2005) (124)
- Oxidative Damage to RNA in Neurodegenerative Diseases (2006) (123)
- Early amyloid accumulation in the hippocampus of SAMP8 mice. (2010) (123)
- Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology (2002) (123)
- Klf15 orchestrates circadian nitrogen homeostasis. (2012) (121)
- Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels. (2005) (121)
- LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease (2010) (120)
- Oxidative damage in Alzheimer’s disease: the metabolic dimension (2000) (119)
- Free radical damage, iron, and Alzheimer's disease (1995) (119)
- Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease (2004) (118)
- Alzheimer's disease: diverse aspects of mitochondrial malfunctioning. (2010) (118)
- Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’ (2011) (117)
- Antioxidant approaches for the treatment of Alzheimer’s disease (2010) (117)
- Mitochondrial failures in Alzheimer's disease (2004) (117)
- Cyclin' toward dementia (2000) (117)
- Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Alzheimer disease (2009) (117)
- Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition (2014) (116)
- Amyloid-β-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons (2010) (115)
- Current approaches in the treatment of Alzheimer's disease. (2008) (114)
- Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4‐hydroxy‐2‐nonenal (2000) (114)
- Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death. (2012) (112)
- All-trans retinoic acid as a novel therapeutic strategy for Alzheimer’s disease (2009) (111)
- DLP1‐dependent mitochondrial fragmentation mediates 1‐methyl‐4‐phenylpyridinium toxicity in neurons: implications for Parkinson’s disease (2011) (111)
- Leptin inhibits glycogen synthase kinase-3β to prevent tau phosphorylation in neuronal cells (2009) (109)
- Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction. (2005) (108)
- The role of cell cycle‐mediated events in Alzheimer's disease (1999) (107)
- Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance (2014) (106)
- Hydroxynonenal, toxic carbonyls, and Alzheimer disease. (2003) (106)
- Carnosine: a versatile antioxidant and antiglycating agent. (2005) (106)
- Formation of aberrant phosphotau fibrillar polymers in neural cultured cells. (2002) (105)
- Increased plasma leptin/fat ratio in patients with chronic renal failure: a cause of malnutrition? (1997) (105)
- The Earliest Stage of Cognitive Impairment in Transition From Normal Aging to Alzheimer Disease Is Marked by Prominent RNA Oxidation in Vulnerable Neurons (2012) (104)
- A suicide note from Alzheimer disease neurons? (1998) (102)
- Oxidative Stress, Antioxidants, and Alzheimer Disease (2000) (101)
- Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. (2004) (100)
- Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease (2003) (100)
- The neuroprotective activities of melatonin against the Alzheimer β‐protein are not mediated by melatonin membrane receptors (2002) (99)
- Signal transduction cascades associated with oxidative stress in Alzheimer's disease. (2007) (98)
- Amyloid beta: the alternate hypothesis. (2006) (98)
- Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle. (2002) (97)
- Activation of oncogenic pathways in degenerating neurons in Alzheimer disease (2000) (97)
- Estimation of body composition from bioelectrical impedance of body segments: Comparison with dual-energy X-ray absorptiometry (1993) (97)
- Mechanisms by which metals promote events connected to neurodegenerative diseases (2001) (96)
- Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease. (2013) (96)
- Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease (1996) (95)
- Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli (1999) (94)
- The Role of Iron and Copper in the Aetiology of Neurodegenerative Disorders (2002) (94)
- Amyloid‐β‐induced toxicity of primary neurons is dependent upon differentiation‐associated increases in tau and cyclin‐dependent kinase 5 expression (2003) (93)
- Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease (2010) (93)
- Increased p27, an essential component of cell cycle control, in Alzheimer's disease (2003) (93)
- Insights into amyloid-β-induced mitochondrial dysfunction in Alzheimer disease (2007) (93)
- Vascular abnormalities: the insidious pathogenesis of Alzheimer’s disease☆ (2000) (93)
- The cell cycle in Alzheimer disease: A unique target for neuropharmacology (2005) (93)
- Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice (2003) (92)
- Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease (2010) (92)
- Nanoparticle and iron chelators as a potential novel Alzheimer therapy. (2010) (91)
- NMR studies of zinc, copper, and iron binding to histidine, the principal metal ion complexing site of amyloid-beta peptide. (2010) (91)
- Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease (2004) (91)
- A novel approach to the identification and quantitative elemental analysis of amyloid deposits--insights into the pathology of Alzheimer's disease. (2009) (90)
- The blood-brain barrier in Alzheimer's disease: novel therapeutic targets and nanodrug delivery. (2012) (90)
- Lipoperoxidation Is Selectively Involved in Progressive Supranuclear Palsy (2000) (90)
- The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. (2009) (90)
- Whole body and regional body composition in patients with chronic renal failure. (1996) (89)
- Faculty Opinions recommendation of Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. (2010) (89)
- Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass (2014) (89)
- Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease. (2004) (89)
- The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1 (2004) (88)
- Tau protein directly interacts with the amyloid β-protein precursor: Implications for Alzheimer's disease (1995) (86)
- Cholesterol, oxidative stress, and Alzheimer's disease: expanding the horizons of pathogenesis. (2002) (86)
- The state versus amyloid-β: the trial of the most wanted criminal in Alzheimer disease (2002) (85)
- Phosphorylated tau: toxic, protective, or none of the above. (2008) (85)
- Bone mass in ankylosing spondylitis. (1986) (85)
- Apoptosis in Alzheimer disease: a mathematical improbability. (2006) (85)
- Dysregulation of the Hypothalamic-Pituitary-Gonadal Axis with Menopause and Andropause Promotes Neurodegenerative Senescence (2005) (83)
- Apoptosis and Alzheimer's Disease (1998) (83)
- Oxidative damage in the olfactory system in Alzheimer's disease (2003) (83)
- Transgenic Mouse Models of Alzheimer’s Disease: Behavioral Testing and Considerations (2009) (83)
- Assessment of renal osteodystrophy in dialysis patients: use of bone alkaline phosphatase, bone mineral density and parathyroid ultrasound in comparison with bone histology. (1997) (83)
- Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies (2002) (82)
- Pathological implications of cell cycle re-entry in Alzheimer disease (2010) (82)
- Oxidative stress in Alzheimers disease (2000) (82)
- Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients (2004) (82)
- Increased permeability of blood–brain barrier on the hippocampus of a murine model of senescence (2007) (81)
- Amyloid-β42 Interacts Mainly with Insoluble Prion Protein in the Alzheimer Brain* (2011) (81)
- Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons. (2011) (81)
- Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain. (2002) (81)
- Oxidative Damage to Nucleic Acids in Human Prion Disease (2002) (81)
- Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease (2010) (81)
- c‐Jun phosphorylation in Alzheimer disease (2007) (80)
- Activation of the extracellular signal‐regulated kinase pathway contributes to the behavioral deficit of fragile x‐syndrome (2012) (79)
- Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans (2011) (79)
- Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease (2009) (79)
- Prion Protein Glycosylation Is Sensitive to Redox Change* (1999) (78)
- Physiological regulation of tau phosphorylation during hibernation (2008) (77)
- Apoptosis and Alzheimer's disease [5] (1998) (77)
- Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis (2003) (75)
- Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. (2008) (75)
- Involvement of maillard reactions in Alzheimer disease (2009) (75)
- Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide (2009) (75)
- Cell cycle deregulation in the neurons of Alzheimer's disease. (2011) (74)
- Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease (2009) (73)
- Biomarkers in Alzheimer's disease: past, present and future. (2010) (73)
- Overexpression of GRK2 in alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions (2006) (73)
- Telomeres and telomerase in Alzheimer’s disease: Epiphenomena or a new focus for therapeutic strategy? (2006) (73)
- The gonadotropin connection in Alzheimer’s disease (2005) (73)
- Clinical benefit and preservation of flavonols in dark chocolate manufacturing. (2008) (72)
- Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-β peptide (2007) (72)
- Comparison of measures of body composition in a trial of low dose growth hormone replacement therapy (1992) (72)
- Amyloid-β, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? (2002) (71)
- Early AGEing and Alzheimer's (1995) (71)
- Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. (2002) (71)
- LRRK2 protein is a component of lewy bodies (2006) (71)
- Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction (2004) (69)
- Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses. (2007) (69)
- Mitochondrial Dynamics in Alzheimer’s Disease (2010) (69)
- Induction of HO-1 and NOS in Doppel-Expressing Mice Devoid of PrP: Implications for Doppel Function (2001) (68)
- Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia (2009) (68)
- LIM Domains Target Actin Regulators Paxillin and Zyxin to Sites of Stress Fiber Strain (2013) (67)
- Measurement of body composition in chronic renal failure: comparison of skinfold anthropometry and bioelectrical impedance with dual energy X-ray absorptiometry. (1996) (67)
- Prevention and treatment of Alzheimer disease and aging: antioxidants. (2007) (67)
- Accelerated α-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells (2004) (67)
- Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer’s disease (2010) (67)
- Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways. (2003) (67)
- Cerebrovascular muscle atrophy is a feature of Alzheimer's disease (1998) (67)
- Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene (2009) (67)
- Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death (2011) (66)
- Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain. (2007) (66)
- Causes versus effects: the increasing complexities of Alzheimer’s disease pathogenesis (2010) (66)
- Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways. (2007) (66)
- Arson: Tracking the Culprit in Alzheimer's Disease (2000) (66)
- Antioxidant protection and neurodegenerative disease: The role of amyloid-β and tau (2006) (66)
- Neurofilamentopathy in Neurodegenerative Diseases (2011) (65)
- Mechanisms and Consequences of Ebolavirus-Induced Lymphocyte Apoptosis (2009) (65)
- Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: Implication in the pathogenesis of Alzheimer’s disease (2008) (65)
- Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease (2005) (65)
- Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases. (2012) (65)
- Oxidative posttranslational modifications in Alzheimer disease (1996) (64)
- Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease (2000) (64)
- Ectopic expression of phospho‐Smad2 in Alzheimer's disease: Uncoupling of the transforming growth factor‐β pathway? (2006) (62)
- The Autistic Phenotype Exhibits a Remarkably Localized Modification of Brain Protein by Products of Free Radical-Induced Lipid Oxidation (2008) (62)
- Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease (2008) (62)
- Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP‐1‐associated regulator of cyclin B, in Alzheimer's disease (2004) (62)
- Redox metals and oxidative abnormalities in human prion diseases (2005) (61)
- Early Induction of Oxidative Stress in Mouse Model of Alzheimer Disease with Reduced Mitochondrial Superoxide Dismutase Activity (2012) (61)
- Down‐regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause‐associated cognitive deficits (2010) (61)
- JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease (2003) (61)
- LRRK2 in Parkinson's disease and dementia with Lewy bodies (2006) (60)
- Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease (2007) (60)
- Causes and consequences of oxidative stress in Alzheimer's disease. (2002) (60)
- Walking Toward a Convergence in Aging Research (2009) (59)
- BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease (2007) (59)
- Distribution, levels, and activation of MEK1 in Alzheimer's disease (2003) (58)
- The cell cycle hypothesis of Alzheimer's disease: suggestions for drug development. (2007) (58)
- Measurement of total body water by bioelectrical impedance in chronic renal failure. (1996) (58)
- Lithium Treatment Decreases Activities of Tau Kinases in a Murine Model of Senescence (2008) (58)
- A phantom for quantitative ultrasound of trabecular bone. (1994) (58)
- Nuclear and mitochondrial DNA oxidation in Alzheimer's disease (2012) (58)
- Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease. (2010) (57)
- Faculty Opinions recommendation of Autophagy protects neuron from Abeta-induced cytotoxicity. (2010) (57)
- Neuroprotective effect of cocoa flavonids on in vitro oxidative stress (2009) (57)
- A Metabolic Basis for Alzheimer Disease (2003) (57)
- Quantitative solubilization and analysis of insoluble paired helical filaments from alzheimer disease (1996) (57)
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- Quantitative Languages for Complex Systems Applied to Biological Structure (2000) (5)
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- Ameliorating slice gaps in multislice magnetic resonance images: an interpolation scheme (2014) (4)
- Absence of Cellular Stress in Brain Following Hypoxia Induced by Arousal from Hibernation in Arctic Ground Squirrels (2005) (4)
- The Role of Oxidative Stress in the Pathological Sequelae of Alzheimer Disease (1998) (4)
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- Drug discovery for neurodegenerative diseases: challenges and novel biochemical targets dedicated to the memory of Mark A. Smith for his inspiring contribution to Alzheimer's disease. (2011) (4)
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- Erratum: Autophagocytosis of mitochondria is prominent in Alzheimer disease (Journal of Neuropathology and Experimental Neurology (2007) 66, (525-532)) (2007) (4)
- Nanoparticles for the Treatment of Alzheimer's Disease: Theoretical Rationale, Present Status and Future Perspectives (2007) (4)
- Treatment advances in Alzheimer's disease based on the oxidative stress model (2009) (4)
- Two Hits and You’re Out? A Novel Mechanistic Hypothesis of Alzheimer Disease (2008) (4)
- Evidence for Oxidative Damage in the Autistic Brain (2009) (4)
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- Methods in Molecular Medicine, Vol. 32 Alzheimer's Disease: Methods and Protocols (2000) (3)
- Neurodegenerative Diseases: Mechanisms and Therapies (2006) (3)
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- Feedback on a feedback loop: the hypothalamic-pituitary-gonadal axis. (2005) (3)
- Erratum: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease (Journal of Neurochemistry 85 (1101-1108)) (2003) (3)
- Oxidative Stress and Neurodegeneration: An Inevitable Consequence of Aging? Implications for Therapy (2010) (3)
- CorrigendumCorrigendum to “Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: Synthesis, neuronal cell culture investigations, and CDK5 docking studies” [Bioorg. Med. Chem. Lett. 11 (2001) 3165–3168] (2011) (3)
- A novel approach for predicting the evolutionary time of acquisition of foreign genes by bacteria: Application of codon usage analyses (2009) (3)
- Biochemistry of neurodegeneration [2] (multiple letters) (2001) (3)
- Alzheimer Disease: Oxidative Stress and Compensatory Responses (2009) (3)
- Alzheimer Research Forum Live Discussion: sports concussions, dementia, and ApoE genotyping: what can scientists tell the public? What's up for research? (2009) (3)
- 4-HYDROXYNONENAL-DERIVED LIPID PF.ROXIDATION END PRODUCTS ARE INCREASED IN ALZHEIMER DISEASE (1997) (3)
- Research report Accelerated a-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells (2004) (3)
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- Oxidative Damage and Antioxidant Responses in Alzheimer's Disease (2002) (3)
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- Measurement of spinal calcium by in vivo neutron activation analysis in osteoporosis. (1981) (2)
- Short Communication Immunocytochemical Evidence That the (3-Protein Precursor Is an Integral Component of Neurofibrillary Tangles of Alzheimer's Disease (2007) (2)
- Oxidative Stress in Parkinson’s Disease (2009) (2)
- Lipoic Acid and N‐Acetyl Cysteine Protect Against Mitochondrial‐Related Oxidative Stress in Fibroblasts from Alzheimer Disease Patients (2007) (2)
- Chapter 1 - Ischemic Tolerance in the Brain: Models and Mechanisms (2002) (2)
- Down syndrome and Alzheimer disease: A "multi-hit" hypothesis based on multiple contributing factors resulting in pleotrophic consequences (2011) (2)
- Antioxidant Therapies in the Prevention and Treatment of Alzheimer Disease (2005) (2)
- Hydroxynonenal-Generated Crosslinking Fluorophore and Mitochondria-derived Lipoic Acid Accumulation in Alzheimer Disease Reveal a Dichotomy of Protein Turnover (2010) (2)
- P3-219 Acetylation: a novel posttranslational modification in Alzheimer disease (2002) (2)
- A total body phantom for use with Lunar dual-energy X-ray absorptiometers. (1998) (2)
- Role of Heme Catabolism in Neurodegenerative Diseases (2002) (2)
- Role of Oxidative Insult and Neuronal Survival in Alzheimer’s and Parkinson’s Diseases (2008) (2)
- 8 – Prion and Alzheimer Diseases: The Road to Pathogenesis is Paved with Copper (2002) (2)
- Causes and consequences of oxidative stress in Alzheimers disease 1,2 1 Guest Editors: Mark A. Smit (2002) (2)
- Whole-body and part-body turnover of 85Sr in Paget's disease. (1983) (2)
- IMUNOHISTOCHEMICAL EVIDENCE OF OXIDATIVE STRESS IN PARKINSONʼS DISEASE (PD) (1996) (2)
- Erratum: Prion protein glycosylation is sensitive to redox change (Journal of Biological Chemistry (1999) 274 (34846-34850)) (2000) (2)
- P3-422: Impaired balance of mitochondrial fission and fusion in susceptible neurons of Alzheimer disease (2008) (2)
- Mitochondria and Neurodegenerative Diseases (2010) (2)
- RAD 21 cohesion protein shows altered levels of expression in the Swedish mutant phenotype of M17 neuroblastoma cells (2010) (2)
- HIGH MOLECULAR WEIGHT NEUROFILAMENT PROTEINS (2001) (2)
- Cellular Respiration and Tumor Suppressor Genes (2009) (2)
- The use of a radiation sensitive CCD camera system to measure bone mineral content in the neonatal forearm: a feasibility study. (1992) (2)
- Erratum: Advanced maillard reaction end products are associated with Alzheimer disease pathology (Proceedings of the National Academy of Sciences of the United States of America (June 7, 1994) 91 (5710-5714) (1995) (2)
- Social Working (1995) (1)
- Oxidative Stress and Neuronal Adaptation in Alzheimer Disease (2003) (1)
- Abstract Meeting of the Bone and Tooth Society, Edinburgh (March, 1984)The prediction of nonunion in tibial fractures using quantitative bone scanning and fracture shift (1985) (1)
- Nutrients and Food Constituents in Cognitive Decline and Neurodegenerative Disease (2013) (1)
- Role of Amyloid‐β in Alzheimer's Disease (2005) (1)
- Rethinking Criminal Justice in Scotland (2017) (1)
- Food Antioxidants and Alzheimer’s Disease (2009) (1)
- Revisiting Moral Panics (2015) (1)
- What oxidative stress tells us about therapeutic targets for Alzheimer's disease (2000) (1)
- Ethics for Scottish social work (2018) (1)
- Learning democracy ; a case study of learning democracy in a peri- urban community development project. (2003) (1)
- P4-354 Luteinizing hormone: A unifying hypothesis for Alzheimer disease etiology, pathogenesis and treatment (2006) (1)
- PO13-357 THE PRIMARY PATHOGENETIC ROLE OF VASCULAR HYPOPERFUSION, AND OXIDATIVE STRESS IN ALZHEIMER DISEASE (2007) (1)
- DOES THE OXIDATIVE STRESS AND CEREBRAL ATHEROSCLEROSIS INITIATE BRAIN HYPOPERFUSION AND THE DEVELOPMENT OF ALZHEIMER DISEASE (2008) (1)
- Whole-body and part-body turnover of 85Sr in Paget's decease (1983) (1)
- P3-275 Phosphorylation dependent control of oxidative modification in Alzheimer disease (2004) (1)
- ALTERED EXTRACELLULAR MATRIX (ECM)-CELL SIGNALING IN ALZHEIMER DISEASE (1999) (1)
- NEUROFILAMENT HEAVY SUBUNIT (NFH) IS A SPECIFIC TARGET OF OXIDATIVE DAMAGE IN THE AXON (1998) (1)
- P2-003 Cholesterol feeding enhances cerebral amyloid beta pathology in beagles (2004) (1)
- SEQUESTRATION OF IRON BY LEWY BODIES IN PARKINSON DISEASE (1999) (1)
- Dementia and testosterone levels in men. (2005) (1)
- Neuronal Oxidative Stress is a Common Feature of Alzheimer’s and Parkinson’s Diseases (1998) (1)
- Nanoparticle-iron Chelator Conjugates as Multifunctional Disease-modifying Drugs for Prevention and Treatment of Alzheimer’s Disease (2012) (1)
- Oxidative Stress and Alzheimer Disease: Mechanisms and Therapeutic Opportunities (2011) (1)
- Brain Composition: Age-Related Changes (2009) (1)
- P3-317: Failure in the control of cell cycle causes neurodegeneration (2008) (1)
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- The Fallacy of Amyloid and Cognition in Alzheimer’s Disease (2006) (1)
- MITOTIC CATASTROPHY IN ALZHEIMER DISEASE (1998) (1)
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- The Calibration of fibre optic probes used for light dosimetry measurements during photodynamic therapy (1995) (1)
- Comparison of in-vivo body composition using two Lunar dual-energy X-ray absorptiometers. (1998) (1)
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- Signal Transduction in Alzheimers Disease (2002) (1)
- Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy (2006) (1)
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- P1-266 The critical role of the ERK pathway in the pathogenesis of Alzheimer's disease (2004) (1)
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- Involvement of Complex Carbohydrate Chemistry in Alzheimer’s Disease (2005) (1)
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- Legal Lobbying : How To Make Your Voice Heard (2013) (1)
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- Challenging Views of Alzheimer's disease (2002) (1)
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- Abstract 1587: Conditional Overexpression of the Oncogene c-Myc Produces Hypertrophic Cardiomyopathy and Results in Mitochondrial Dysfunction at Complex I (2008) (0)
- P1-351: A novel approach to diagnosis: Antigen-antibody disassociation in Alzheimer's disease (2008) (0)
- Upcoming Meetings Related to Alzheimer's Disease. (2008) (0)
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- Faculty Opinions recommendation of Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. (2010) (0)
- ADVANCED GLYCATION AND LIPID MODIFICATION OF ROSENTHAL FIBERS IN ALEXANDERʼS DISEASE (1997) (0)
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- The Importance of Histochemical Detection of Oxidative Damage in Tissue (2010) (0)
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- Immunocytochemical Evidence That the ( 3-Protein Precursor Is an Integral Component of Neurofibrillary Tangles of Alzheimer ' s Disease (2014) (0)
- O4-02-08 Mitochondrial autophagocytosis in Alzheimer disease (2006) (0)
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- Foreword: Challenging views of Alzheimer's disease – 2004 (2005) (0)
- P4-166: Overexpression of amyloid precursor protein causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins (2008) (0)
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- Oxidative Damage to RNA in Aging and Neurodegenerative Disorders (2012) (0)
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- Short Communication f3PP and Tau Interaction A Possible Link between Amyloid and Neurofibrillary Tangles in Alzheimer's Disease (2007) (0)
- Cell cycle dysregulation and neurodegenerative diseases (2007) (0)
- Faculty Opinions recommendation of Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. (2010) (0)
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- Faculty Opinions recommendation of Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. (2009) (0)
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- Bonemass innodalprimary generalised osteoarthrosis (1984) (0)
- R-α-lipoic acid as a potent agent of mitochondrial protection in alzheimer’s disease (2012) (0)
- Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest. (2012) (0)
- 6th Conference of Neurodegenerative Disorders: Common Molecular Mechanisms, Tobago, West Indies (2001) (0)
- Activation analysis by252californium for the estimation of the calcium content of bone (1976) (0)
- Sir Martin Roth – A Debt of Gratitude (2007) (0)
- Antibody‐Antigen Dissociation: A Novel Diagnostic Tool in Alzheimer Disease (2008) (0)
- The effect of dialysate calcium concentration on 1alpha-hydroxyvitamin D3 on skeletal calcium loss and hyperparathyroidism in haemodialysis patients. (1977) (0)
- P1-105: Neurodegeneration and iron overload in transgenic mice expressing a mutant form of the ferritin light polypeptide gene (2008) (0)
- ALZHEIMER DISEASE IS MARKED BY A MAJOR SHIFT IN REDOX BALANCE (1999) (0)
- Mitochondrial autophagocytosis in Alzheimer disease: 126.6 (2007) (0)
- Decline in mitochondrial bioenergetics underlies central insulin resistance in streptozocin-induced model of sporadic Alzheimer's disease (2011) (0)
- Professional Grant Writers [2] (multiple letters) (2004) (0)
- Apoptosis Ebolavirus-Induced Lymphocyte Mechanisms and Consequences of (2010) (0)
- Association of leptin receptor with neurofibrillary tangles of Alzheimer disease (2010) (0)
- Journal of Alzheimer's disease established as a leading journal. (2001) (0)
- Oxidative Adaptation in Aging and Alzheimer’s Disease: The Roles of Amyloid and Tau (2005) (0)
- ALDEHYDE-MODIFICATION OF THE NEUROFILAMENT COMPONENT OF NEUROFIBRILLARY TANGLES IN ALZHEIMER DISEASE (1993) (0)
- Giant Lipid Membranes Supported by Glass Beads for Membrane-Protein Interaction Studies (2018) (0)
- Senile plaques and neurofibrillary tangles: The concurrent lesions of alzheimer's disease (1995) (0)
- Metabolic and biochemical alterations in Alzheimer's disease: facts and fictions (2011) (0)
- Association of mitochondrial signaling in Alzheimer's disease and hypoxia (2011) (0)
- P3-229 P130, a regulator of the G1 phase of the cell cycle, in Alzheimer disease: Evidence of a stuttered cell cycle (2006) (0)
- Symposium (2004) (0)
- Total antioxidant status in newly diagnosed Alzheimer's patients: Population based study (2010) (0)
- Oxidative Stress in Alzheimer Disease: The Earliest Cytological and Biochemical Feature (2004) (0)
- EFFECT OF CHRONIC EXPRESSION OF HEME OXYGENASE-1 IN NEURONAL CELLS: RELEVANCE TO NEURODEGENERATIVE DISEASES (1997) (0)
- CDK11/pitslre protein kinase is differentially expressed in hippocampus of Alzheimer patients (2009) (0)
- Cell Cycle Activation and the Amyloid-β Protein in Alzheimer’s Disease (2006) (0)
- Leave the good amyloid β alone [3] (2004) (0)
- Neuropathology of Dementing Disorders: Edited by William R. Markesbery, Arnold, London, 1998. 316 pages, Price £125, ISBN: 0-34059-037-8 (2002) (0)
- Contents Vol. 94, 2008 (2008) (0)
- Mitochondria Dynamics Abnormalities in Alzheimer Disease (2009) (0)
- Neurodegenerative Phenotypes Induced by MYC‐Driven Neuronal Cell Cycle Re‐entry: Relevance to Alzheimer Disease (2008) (0)
- Increased oxidative stress involving olfactory neurons in Alzheimer disease (2000) (0)
- Book review (2007) (0)
- Oxidative Stress in Aging and Neurodegenerative Diseases: From Biology to Therapy, Perugia, Italy, May 2003 (2004) (0)
- Neurogenesis in Alzheimer’s Disease (2006) (0)
- Phosphorylation, Microtubule Binding and Aggregation of Tau Protein in Alzheimer's Disease (2002) (0)
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