Mark H Ginsberg

Q: What Schools Are Affiliated With Mark H Ginsberg

Mark H Ginsberg is affiliated with the following schools: University of California, Berkeley, Stony Brook University, San Diego State University, University of California, San Diego, Rockefeller University, Stanford University, University of Toronto, University of Virginia, University of Washington, Harvard University

Mark H Ginsberg's AcademicInfluence.com Rankings

Mark H Ginsberg

Computer Science

#3066

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#3216

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Computational Linguistics

#111

World Rank

#113

Historical Rank

Machine Learning

#290

World Rank

#294

Historical Rank

Artificial Intelligence

#465

World Rank

#474

Historical Rank

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Computer Science

Mark H Ginsberg's Degrees

PhD Computer Science Stanford University
Masters Computer Science University of California, Berkeley

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Mark H Ginsberg's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cell Migration: Integrating Signals from Front to Back (2003) (4885)
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation (2003) (1056)
The final steps of integrin activation: the end game (2010) (977)
Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors. (1986) (851)
Networks and crosstalk: integrin signalling spreads (2002) (796)
Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. (1995) (777)
Integrin cytoplasmic domains mediate inside-out signal transduction (1994) (734)
The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation* (1999) (730)
Structural Basis of Integrin Activation by Talin (2007) (693)
Integrin cytoplasmic domain-binding proteins. (2000) (601)
Integrin activation controls metastasis in human breast cancer. (2001) (585)
Src kinase activation by direct interaction with the integrin β cytoplasmic domain (2003) (579)
The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets. (1985) (552)
Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. (1991) (534)
Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway (1997) (527)
Structural determinants of integrin recognition by talin. (2003) (519)
Inside-out integrin signalling (1992) (457)
beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. (1998) (421)
The Phosphotyrosine Binding-like Domain of Talin Activates Integrins* (2002) (419)
A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. (1990) (418)
Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling (2003) (415)
Regulation of Cell Migration by the Calcium-dependent Protease Calpain* (1997) (403)
A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein. (1986) (403)
Regulation of integrin activation. (2011) (399)
Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity (1996) (397)
Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3 (2006) (396)
Integrin regulation. (2005) (392)
Breaking the Integrin Hinge (1996) (381)
Detection and partial characterization of an inhibitor of plasminogen activator in human platelets. (1984) (375)
Corrigendum: Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability (2008) (371)
Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix (1995) (363)
Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. (1988) (362)
Binding of paxillin to α4 integrins modifies integrin-dependent biological responses (1999) (360)
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. (2011) (342)
RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences* (2009) (326)
PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. (2001) (321)
Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function. (1991) (320)
Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. (1990) (319)
Integrin activation takes shape (2002) (319)
The structure of an integrin/talin complex reveals the basis of inside‐out signal transduction (2009) (313)
Integrin β Cytoplasmic Domains Differentially Bind to Cytoskeletal Proteins* (1998) (311)
The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling (2009) (308)
KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions (2007) (306)
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity (2010) (305)
The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit. (1990) (299)
Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. (1991) (294)
Complementation of dominant suppression implicates CD98 in integrin activation (1997) (293)
Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. (2006) (292)
Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. (1991) (279)
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis (2007) (278)
Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion. (1988) (262)
Recreation of the terminal events in physiological integrin activation (2010) (259)
Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption (2007) (255)
Integrin modulation and signaling in leukocyte adhesion and migration (2007) (253)
Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors. (1994) (243)
Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets. (1985) (241)
Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration (2001) (233)
CD98hc (SLC3A2) mediates integrin signaling. (2005) (230)
An α4 integrin–paxillin–Arf-GAP complex restricts Rac activation to the leading edge of migrating cells (2005) (226)
Evidence that three adhesive proteins interact with a common recognition site on activated platelets. (1984) (225)
Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. (1994) (223)
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. (2012) (222)
Adhesive signaling in platelets. (1994) (220)
Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin (1993) (217)
The Conserved Membrane-proximal Region of an Integrin Cytoplasmic Domain Specifies Ligand Binding Affinity (*) (1995) (214)
Integrin-mediated cell adhesion: the extracellular face. (1994) (213)
Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. (1990) (213)
Cellular adhesion: GPIIb-IIIa as a prototypic adhesion receptor. (1989) (211)
Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions (1993) (206)
"Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains. (1994) (204)
Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity (2009) (201)
Trans-dominant inhibition of integrin function. (1996) (199)
Ras GTPases: integrins' friends or foes? (2003) (199)
β1 Integrins Participate in the Hypertrophic Response of Rat Ventricular Myocytes (1998) (199)
Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets. (1987) (195)
The inner world of cell adhesion: integrin cytoplasmic domains. (1994) (193)
Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins. (1994) (193)
Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology. (1997) (192)
Talin Phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitination and cell migration (2009) (192)
Specific and saturable binding of plasma fibronectin to thrombin-stimulated human platelets. (1981) (190)
A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD11b/CD18). (1990) (188)
Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit (1995) (184)
A discrete sequence in a platelet integrin is involved in ligand recognition (1991) (183)
Faculty Opinions recommendation of VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. (2006) (182)
Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK (1993) (180)
Localization of internal pools of membrane glycoproteins involved in platelet adhesive responses. (1986) (180)
Long range propagation of conformational changes in integrin alpha IIb beta 3. (1993) (174)
Activation of Syk protein tyrosine kinase through interaction with integrin β cytoplasmic domains (2001) (171)
Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion. (1985) (171)
Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. (1990) (171)
Efficient surface expression of platelet GPIIb-IIIa requires both subunits. (1989) (170)
The Kindler Syndrome Protein Is Regulated by Transforming Growth Factor-β and Involved in Integrin-mediated Adhesion* (2004) (165)
Regulation of the pp72syk protein tyrosine kinase by platelet integrin αIIbβ3 (1997) (165)
Integrin signaling in vascular biology. (1997) (164)
Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 Subunit (*) (1995) (162)
Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets. (1999) (161)
Talin forges the links between integrins and actin (2003) (158)
Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences (1994) (156)
CD98 at the crossroads of adaptive immunity and cancer (2012) (152)
Faculty Opinions recommendation of Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. (2003) (152)
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3 (2008) (152)
Mutation of the cytoplasmic domain of the integrin beta 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis. (1995) (151)
Protein Kinase A Governs a RhoA-RhoGDI Protrusion-Retraction Pacemaker in Migrating Cells (2011) (149)
Matrix-specific suppression of integrin activation in shear stress signaling. (2006) (149)
Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain* (2001) (148)
Arginyl-glycyl-aspartic acid sequences and fibrinogen binding to platelets. (1987) (148)
Microfluidic devices for studies of shear-dependent platelet adhesion. (2008) (147)
Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. (2008) (142)
Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa). (1991) (141)
Regulation of cardiovascular development and integrity by the Heart of Glass-Cerebral Cavernous Malformation pathway (2009) (141)
Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia. (1986) (139)
Activated R-Ras, Rac1, Pi 3-Kinase and Pkcε Can Each Restore Cell Spreading Inhibited by Isolated Integrin β1 Cytoplasmic Domains (2000) (139)
Tyrosine Phosphorylation of the β3 Cytoplasmic Domain Mediates Integrin-Cytoskeletal Interactions* (1998) (139)
The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3 (2013) (137)
Platelet-collagen adhesion: inhibition by a monoclonal antibody that binds glycoprotein IIb (1984) (137)
A Single Immunoglobulin-like Domain of the Human Neural Cell Adhesion Molecule L1 Supports Adhesion by Multiple Vascular and Platelet Integrins (1997) (136)
Faculty Opinions recommendation of Kindlin-2 (Mig-2): a co-activator of beta3 integrins. (2008) (136)
Transmembrane Domain Helix Packing Stabilizes Integrin αIIbβ3 in the Low Affinity State* (2005) (136)
Conformational transitions in the cell binding domain of fibronectin. (1995) (136)
Release of platelet constituents by monosodium urate crystals. (1977) (135)
Reduced surface expression and binding of fibronectin by thrombin-stimulated thrombasthenic platelets. (1983) (134)
Distinct Domains of CD98hc Regulate Integrins and Amino Acid Transport* (2001) (134)
α4 integrins and the immune response (2002) (133)
Plasminogen interacts with human platelets through two distinct mechanisms. (1986) (132)
Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease (2012) (130)
The N-terminal SH2 Domains of Syk and ZAP-70 Mediate Phosphotyrosine-independent Binding to Integrin β Cytoplasmic Domains* (2002) (130)
Spatial restriction of α4 integrin phosphorylation regulates lamellipodial stability and α4β1-dependent cell migration (2003) (130)
Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIa. (1993) (130)
Amino acid sequences in fibrinogen mediating its interaction with its platelet receptor, GPIIbIIIa. (1989) (129)
Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. (2010) (128)
Integrin activation (2014) (127)
β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation* (2009) (127)
Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen (1991) (126)
A spontaneous mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) helps define a ligand binding site. (1992) (125)
Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells. (1986) (125)
Ligand bridging mediates integrin alpha IIb beta 3 (platelet GPIIB-IIIA) dependent homotypic and heterotypic cell-cell interactions. (1991) (124)
Affinity Modulation of Platelet Integrin αIIbβ3 by β3-Endonexin, a Selective Binding Partner of the β3 Integrin Cytoplasmic Tail (1997) (124)
Integrins in the immune system. (1999) (122)
A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa). (1994) (122)
NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution. (2001) (122)
Integrin α4β1 signaling is required for lymphangiogenesis and tumor metastasis (Cancer Research (2010) 70, (3042-51) DOI (2010) (121)
Influence of fibrillar collagen structure on the mechanisms of platelet thrombus formation under flow. (1999) (119)
Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain. (2001) (119)
Specification of the Direction of Adhesive Signaling by the Integrin β Cytoplasmic Domain* (2005) (119)
Concanavalin A induces interactions between surface glycoproteins and the platelet cytoskeleton (1982) (118)
A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques (1992) (118)
A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. (2011) (117)
Class- and Splice Variant-specific Association of CD98 with Integrin β Cytoplasmic Domains* (2000) (117)
Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex. (1994) (116)
The talin-tail interaction places integrin activation on FERM ground. (2004) (115)
The antithrombotic potential of selective blockade of talin-dependent integrin αIIbβ3 (platelet GPIIb-IIIa) activation (2007) (114)
Immunochemical and amino-terminal sequence comparison of two cytoadhesins indicates they contain similar or identical beta subunits and distinct alpha subunits. (1987) (114)
Ultrastructural localization of human platelet thrombospondin, fibrinogen, fibronectin, and von Willebrand factor in frozen thin section. (1985) (113)
Calpain cleavage of integrin β cytoplasmic domains (1999) (112)
Small-molecule synergist of the Wnt/β-catenin signaling pathway (2007) (111)
Isolation and characterization of a platelet membrane protein related to the vitronectin receptor. (1989) (111)
Multimeric structure of platelet factor VIII/von Willebrand factor: the presence of larger multimers and their reassociation with thrombin-stimulated platelets. (1982) (110)
Competition for Talin Results in Trans-dominant Inhibition of Integrin Activation* (2004) (110)
Ligand binding to GPIIb-IIIa: a status report. (1992) (108)
Identification of a New Biological Function for the Integrin αvβ3: Initiation of Fibronectin Matrix Assembly (1996) (108)
Reconstruction of integrin activation. (2012) (107)
Rap1 and its effector KRIT1/CCM1 regulate β-catenin signaling (2010) (107)
Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes (1987) (106)
Corrigendum: Regulation of cardiovascular development and integrity by the heart of glass– cerebral cavernous malformation protein pathway (2009) (106)
Phosphorylation of the Integrin α4 Cytoplasmic Domain Regulates Paxillin Binding* (2001) (105)
Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera. (1992) (103)
Chemical cross-linking of arginyl-glycyl-aspartic acid peptides to an adhesion receptor on platelets. (1988) (102)
Elevated plasma levels of ED1+ ("cellular") fibronectin in patients with vascular injury. (1989) (101)
α4β1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the α4-cytoplasmic domain (2005) (100)
Talin and kindlin: the one-two punch in integrin activation (2014) (100)
The mechanism of thrombin-induced platelet factor 4 secretion. (1980) (99)
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. (2007) (97)
Molecular mechanism of inside‐out integrin regulation (2011) (97)
The Rap1-RIAM-talin axis of integrin activation and blood cell function. (2016) (97)
Paxillin Binding to a Conserved Sequence Motif in the α4 Integrin Cytoplasmic Domain* (2000) (95)
The small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathway. (1999) (94)
CD98hc facilitates B cell proliferation and adaptive humoral immunity (2009) (94)
Talin activates integrins by altering the topology of the β transmembrane domain (2012) (93)
Soluble VCAM-1 binding to alpha4 integrins is cell-type specific and activation dependent and is disrupted during apoptosis in T cells. (2000) (93)
α4 Integrins are Type I cAMP-dependent protein kinase-anchoring proteins (2007) (92)
Integrin-mediated protein kinase A activation at the leading edge of migrating cells. (2008) (92)
The Death Effector Domain of PEA-15 Is Involved in Its Regulation of Integrin Activation* (1998) (90)
Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) recognizes multiple sites in fibronectin. (1991) (90)
Paxillin Binding to the α4 Integrin Subunit Stimulates LFA-1 (Integrin αLβ2)-Dependent T Cell Migration by Augmenting the Activation of Focal Adhesion Kinase/Proline-Rich Tyrosine Kinase-21 (2003) (90)
Monoclonal Antibodies Specific for a Conformationally Altered State of Fibrinogen (1990) (89)
Evaluation of alpha-tocopherol antioxidant activity in microsomal lipid peroxidation as detected by low-level chemiluminescence. (1984) (89)
Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. (2003) (89)
Identification and quantitation of platelet-associated fibronectin antigen. (1979) (89)
Inside-out signaling through integrins. (1996) (88)
Effects of OKM5, a monoclonal antibody to glycoprotein IV, on platelet aggregation and thrombospondin surface expression. (1990) (87)
Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura. (1991) (86)
Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. (2015) (86)
Immunofluorescent localization of adhesive glycoproteins in resting and thrombin-stimulated platelets. (1984) (86)
A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration (2015) (84)
Structural Determinants of Integrin Binding to the Talin Rod*S⃞ (2009) (82)
Analysis of the tetraspanin CD9-integrin alphaIIbbeta3 (GPIIb-IIIa) complex in platelet membranes and transfected cells. (1997) (80)
An easy to assemble microfluidic perfusion device with a magnetic clamp. (2009) (80)
Talin1 and Rap1 Are Critical for Osteoclast Function (2012) (80)
The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. (2007) (79)
Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state. (2005) (79)
Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis (2016) (79)
Integrin‐associated proteins as potential therapeutic targets (2008) (78)
Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. (2005) (78)
A Conserved Sequence Motif in the Integrin β3 Cytoplasmic Domain Is Required for Its Specific Interaction with β3-Endonexin* (1997) (78)
Different specificities of platelet-associated and plasma autoantibodies to platelet GPIIb-IIIa in patients with chronic immune thrombocytopenic purpura. (1992) (78)
Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. (2009) (78)
Thrombin increases expression of fibronectin antigen on the platelet surface. (1980) (77)
Integrin activation by talin (2005) (77)
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration (2006) (77)
Lipoproteins containing apoprotein B are a major regulator of neutrophil responses to monosodium urate crystals. (1984) (76)
Dynamic regulation of integrins (1995) (76)
CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. (2016) (76)
Two modes of integrin activation form a binary molecular switch in adhesion maturation (2013) (75)
Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration (2012) (75)
Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism. (2000) (75)
Long range propagation of conformational changes in integrin α(IIb)β3 (1993) (75)
Integrin alpha IIb beta 3 and platelet function. (1997) (74)
Structural Basis for Phosphatidylinositol Phosphate Kinase Type Iγ Binding to Talin at Focal Adhesions*[boxs] (2005) (74)
CD98hc (SLC3A2) Interaction with β1 Integrins Is Required for Transformation* (2004) (74)
Fibrinogen, fibrinogen receptors, and the peptides that inhibit these interactions. (1987) (73)
Blocking neutrophil integrin activation prevents ischemia–reperfusion injury (2015) (73)
A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro. (1997) (73)
Integrin α4β1 Promotes Focal Adhesion Kinase-Independent Cell Motility via α4 Cytoplasmic Domain-Specific Activation of c-Src (2005) (73)
CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling (2007) (72)
Beta1 integrins participate in the hypertrophic response of rat ventricular myocytes. (1998) (72)
Interaction of thrombospondin with resting and stimulated human platelets. (1986) (72)
Snorkeling Basic Amino Acid Side Chains Regulate Transmembrane Integrin Signalling (2011) (72)
Design and chemical synthesis of a neoprotein structural model for the cytoplasmic domain of a multisubunit cell-surface receptor: integrin alpha IIb beta 3 (platelet GPIIb-IIIa). (1994) (71)
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations (2017) (70)
A receptor-induced binding site in fibrinogen elicited by its interaction with platelet membrane glycoprotein IIb-IIIa. (1991) (70)
Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. (2006) (70)
Integrin signaling: roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK. (1995) (69)
UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3. (2008) (69)
New synthesis of a platelet-specific protein: platelet factor 4 synthesis in a megakaryocyte-enriched rabbit bone marrow culture system (1983) (68)
PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2. (2007) (68)
Integrin α4β1-dependent T Cell Migration Requires Both Phosphorylation and Dephosphorylation of the α4 Cytoplasmic Domain to Regulate the Reversible Binding of Paxillin* (2003) (67)
The nucleus of endothelial cell as a sensor of blood flow direction (2013) (66)
Neurobiology: New Connections between Integrins and Axon Guidance (2004) (66)
Differential structural requirements for fibrinogen binding to platelets and to endothelial cells (1989) (65)
Intravascular release of intact cellular fibronectin during oxidant-induced injury of the in vitro perfused rabbit lung. (1986) (65)
Structural basis of the junctional anchorage of the cerebral cavernous malformations complex (2012) (65)
Enhancement of platelet response to immune complexes and IgG aggregates by lipid A-rich bacterial lipopolysaccharides (1978) (64)
A mechanism of Rap1-induced stabilization of endothelial cell–cell junctions (2011) (64)
Immunoglobulin G independent activation of the classical complement pathway by monosodium urate crystals. (1979) (64)
Affinity Modulation of Integrin t 5/31: Regulation of the Functional Response by Soluble Fibronectin (1993) (63)
Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. (2008) (62)
Integrin αIIbβ3 and Platelet Function (1997) (62)
PEA-15 Binding to ERK1/2 MAPKs Is Required for Its Modulation of Integrin Activation* (2003) (62)
Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3. (1995) (62)
Loss of T Cell CD98 H Chain Specifically Ablates T Cell Clonal Expansion and Protects from Autoimmunity (2011) (61)
Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function. (1987) (61)
CD98hc (SLC3A2) Interaction with the Integrin β Subunit Cytoplasmic Domain Mediates Adhesive Signaling* (2007) (61)
Endothelial cell talin1 is essential for embryonic angiogenesis (2011) (61)
Distinct Functions of Integrin ct and/3 Subunit Cytoplasmic Domains in Cell Spreading and Formation of Focal Adhesions (1993) (60)
Plasma Protein Binding by Monosodium Urate Crystals (1983) (60)
Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. (2003) (60)
Polymorphonuclear leukocyte responses to monosodium urate crystals: modification by adsorbed serum proteins. (1979) (59)
A Fragment of Paxillin Binds the α4Integrin Cytoplasmic Domain (Tail) and Selectively Inhibits α4-Mediated Cell Migration* (2002) (58)
Calpain cleavage of integrin beta cytoplasmic domains. (1999) (57)
The platelet‐fibrinogen interaction (1984) (57)
High mutation detection rates in cerebral cavernous malformation upon stringent inclusion criteria: one-third of probands are minors (2014) (56)
ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding. (2014) (55)
Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. (1997) (55)
Kindlins, Integrin Activation and the Regulation of Talin Recruitment to αIIbβ3 (2012) (55)
The Affinity of Integrin α4β1 Governs Lymphocyte Migration1 (2001) (55)
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. (2007) (54)
Localized &agr;4 Integrin Phosphorylation Directs Shear Stress–Induced Endothelial Cell Alignment (2008) (54)
5 – Expression and Function of Adhesive Proteins on the Platelet Surface (1986) (52)
High Refractive Index Silicone Gels for Simultaneous Total Internal Reflection Fluorescence and Traction Force Microscopy of Adherent Cells (2011) (51)
CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction. (2014) (50)
Binding of Paxillin to the α9 Integrin Cytoplasmic Domain Inhibits Cell Spreading* (2001) (50)
Monoclonal Antibodies to Ligand-occupied Conformers of Integrin aIIbP 3 ( Glycoprotein IIb-IIIa ) Alter Receptor Affinity , Specificity , and Function * (2001) (50)
Determination of adhesion force between single cell pairs generated by activated GpIIb-IIIa receptors. (1993) (49)
Fibronectin expression on the platelet surface occurs in concert with secretion. (1981) (49)
Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase. (2002) (48)
Subcellular Localization of Talin Is Regulated by Inter-domain Interactions* (2012) (48)
The inflammatory reaction to crystals. (1988) (48)
The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function (2000) (48)
Talin phosphorylation sites mapped by mass spectrometry (2005) (46)
Integrin activation. (2008) (46)
Platelet adhesion receptors. (1995) (46)
Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. (2019) (46)
Alternative proteolytic processing of platelet membrane glycoprotein IIb. (1988) (45)
Release of platelet factor 4 into the blood after cold challenge of patients with cold urticaria. (1984) (45)
Centripetal myosin redistribution in thrombin-stimulated platelets. Relationship to platelet Factor 4 secretion. (1984) (44)
Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability* (2016) (44)
An experimentally derived database of candidate Ras-interacting proteins. (2007) (44)
Release of soluble fibronectin containing an extra type III domain (ED1) during acute pulmonary injury mediated by oxidants or leukocytes in vivo. (1988) (44)
THE LOCALIZATION OF PLATELET GpIIb-IIIa RELATED PROTEINS IN ENDOTHELIAL CELL ADHESION STRUCTURE (1988) (44)
Human endothelial cells synthesize, process, and secrete fibronectin molecules bearing an alternatively spliced type III homology (ED1). (1990) (43)
Urate crystal--dependent cleavage of Hageman factor in human plasma and synovial fluid. (1980) (43)
Platelet activation by a relapsing fever spirochaete results in enhanced bacterium–platelet interaction via integrin αIIbβ3 activation (2001) (43)
Antitumor activity of an anti‐CD98 antibody (2015) (42)
The detection, immunofluorescent localization, and thrombin induced release of human platelet-associated fibronectin antigen. (1979) (42)
Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem (2019) (40)
Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2) (2009) (40)
The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail* (2013) (40)
Identification of a new biological function for the integrin alpha v beta 3: initiation of fibronectin matrix assembly. (1996) (39)
Platelet glycoprotein IIb-IIIa (alpha IIb beta 3 integrin) confers fibrinogen- and activation-dependent aggregation on heterologous cells. (1991) (39)
The role of cell surface proteins in platelet stimulation by monosodium urate crystals. (1982) (39)
Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy (2008) (39)
A Membrane-distal Segment of the Integrin αIIbCytoplasmic Domain Regulates Integrin Activation* (2001) (38)
Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity (2015) (38)
Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the α4 integrin (2010) (37)
Blockade of α4 Integrin Signaling Ameliorates the Metabolic Consequences of High-Fat Diet–Induced Obesity (2008) (37)
Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking (2017) (37)
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. (2005) (37)
High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis (2019) (36)
Identification of a new class of inducible receptors on platelets. Thrombospondin interacts with platelets via a GPIIb-IIIa-independent mechanism. (1986) (36)
Cytochrome P450 1A1 promoter as a genetic switch for the regulatable and physiological expression of a plasma protein in transgenic mice. (1995) (35)
An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. (2015) (35)
Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15 (2006) (35)
Effect of chemical conjugation of recombinant single-chain urokinase-type plasminogen activator with monoclonal antiplatelet antibodies on platelet aggregation and on plasma clot lysis in vitro and in vivo. (1991) (34)
Localization of a PlA1 epitope to the amino terminal 66 residues of platelet glycoprotein IIIa. (1992) (34)
A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. (2002) (34)
Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7. (2002) (34)
Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin. (2003) (34)
New approaches to blockade of alpha4-integrins, proven therapeutic targets in chronic inflammation. (2006) (34)
Characterization of a gain of function mutation of integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa). (1992) (34)
Divalent cation-dependent and independent surface expression of thrombospondin on thrombin-stimulated human platelets. (1987) (32)
Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes. (2019) (32)
Differences in regulation of Drosophila and vertebrate integrin affinity by talin. (2008) (31)
The affinity of integrin alpha(4)beta(1) governs lymphocyte migration. (2001) (31)
Direct evidence for the interaction of platelet surface membrane proteins GPIIb and III with cytoskeletal components: Protein crosslinking studies (1985) (30)
α4 Integrins in Cardiovascular Development and Diseases (2000) (30)
The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand* (2015) (30)
Fibronectin binding to thrombin-stimulated platelets: evidence for fibrin(ogen) independent and dependent pathways. (1985) (29)
Talin1 is the Principal Platelet Rap1 Effector of Integrin Activation. (2020) (29)
Expression of intracellular fibrinogen on the surface of stimulated platelets. (1986) (29)
Inhibitors of cell migration that inhibit intracellular paxillin/alpha4 binding: a well-documented use of positional scanning libraries. (2002) (29)
Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool (2017) (29)
Ras GTPases: integrins' friends or foes? (2004) (28)
Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor. (2015) (28)
cDNA clones for human platelet GPIIb corresponding to mRNA from megakaryocytes and HEL cells. Evidence for an extensive homology to other Arg-Gly-Asp adhesion receptors. (1988) (28)
Plasma protein binding by monosodium urate crystals. Analysis by two-dimensional gel electrophoresis. (1983) (28)
Adsorption of polymorphonuclear leukocyte lysosomal enzymes to monosodium urate crystals. (1977) (28)
Ultrastructural localization of coagulation factor V in human platelets. (1986) (28)
Ubiquitylation of CD98 limits cell proliferation and clonal expansion (2015) (27)
A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin. (1997) (27)
Immunoblot analysis of platelet glyeoprotein IIb in patients with Glanzmann thrombasthenia in Israel (1989) (27)
Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. (2018) (27)
C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution. (2003) (27)
Neurite outgrowth on a fibronectin isoform expressed during peripheral nerve regeneration is mediated by the interaction of paxillin with α4β1 integrins (2007) (27)
Molecular Cloning and Expression of the cDNA for a 3 Subunit of Human a 3 aJVLA-3), an Integrin Receptor for Fibronectin, Laminin, and Collagen (1991) (26)
Mechanisms for expression of thrombospondin on the platelet cell surface. (1987) (26)
Consequences of the interaction of platelet membrane glycoprotein GPIIb-IIIa (αIIbβ3) and its ligands (1992) (26)
A Small Molecule That Inhibits the Interaction of Paxillin and α4 Integrin Inhibits Accumulation of Mononuclear Leukocytes at a Site of Inflammation* (2010) (25)
Binding of fibronectin to alpha-granule-deficient platelets (1983) (25)
Binding of Paxillin to the alpha 9 Integrin Cytoplasmic Domain Inhibits Cell Spreading. (2001) (25)
Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation. (1995) (25)
A Mutation in the Subunit of the Platelet Integrin IIbβ3 Identifies a Novel Region Important for Ligand Binding (1999) (25)
Integrin signaling: roles for the cytoplasmic tails of αIIbβ3 in the tyrosine phosphorylation of pp125 FAK (1995) (25)
Phenotypic Characterization of Murine Models of Cerebral Cavernous Malformations (2017) (24)
CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis. (2017) (24)
Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations (2019) (24)
SnapShot: Talin and the Modular Nature of the Integrin Adhesome (2014) (23)
Integrin Activation (2001) (23)
Integrin Activation Controls Regulatory T Cell–Mediated Peripheral Tolerance (2018) (23)
Fibrinogen-endothelial cell interaction in vitro: a pathway mediated by an Arg-Gly-Asp recognition specificity (1989) (23)
Platelet membrane glycoprotein IIb heavy chain forms a complex with glycoprotein IIIa that binds Arg-Gly-Asp peptides. (1989) (23)
Erratum: Basic amino-acid side chains regulate transmembrane integrin signalling (2013) (22)
The selective binding of aggregated IgG to lipid A-rich bacterial lipopolysaccharides. (1978) (22)
Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling. (2020) (22)
Enhanced Integrin α4β1–Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes (2015) (22)
Purification of a heparin-neutralizing protein from rabbit platelets and its homology with human platelet Factor 4. (1979) (22)
Biomarkers of cavernous angioma with symptomatic hemorrhage. (2019) (22)
Apolipoprotein B mediates the capacity of low density lipoprotein to suppress neutrophil stimulation by particulates. (1986) (22)
Mechanisms of cellular interaction with monosodium urate crystals. IgG-dependent and IgG-independent platelet stimulation by urate crystals. (1978) (21)
The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human αVβ3 Integrin via Steric Hindrance. (2017) (21)
Low density lipoprotein inhibits the physical interaction of phlogistic crystals and inflammatory cells. (1986) (20)
A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation. (2001) (20)
Distinct integrin activation pathways for effector and regulatory T cell trafficking and function (2020) (20)
Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. (2021) (20)
Annular Anionic Lipids Stabilize the Integrin αIIbβ3 Transmembrane Complex* (2015) (19)
β7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25hiFoxP3+ Regulatory T Cells (2019) (19)
The platelet-fibrinogen interaction. Evidence for proximity of the A alpha chain of fibrinogen to platelet membrane glycoproteins IIb/III. (1984) (19)
Fine-tuning Tumor Immunity with Integrin Trans-regulation (2015) (19)
Analysis of the tetraspanin CD 9 – integrin α IIb β 3 ( GPIIb-IIIa ) complex in platelet membranes and transfected cells (1997) (18)
CD98 Regulates Vascular Smooth Muscle Cell Proliferation in Atherosclerosis (2017) (18)
Structural integrity of the glycoprotein IIb and IIIa genes in Glanzmann thrombasthenia patients from Israel. (1988) (18)
Receptors on platelets. (1994) (18)
Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development (2018) (18)
A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors* (2016) (17)
R-Ras C-terminal sequences are sufficient to confer R-Ras specificity toH-Ras (2002) (17)
Alpha4 integrins in cardiovascular development and diseases. (2000) (16)
Blockade of Platelet GPIIB-IIIA (Integrin αIIbβ3) in Flowing Human Blood Leads to Passivation of Prothrombotic Surfaces (2002) (16)
RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. (2015) (16)
R-Ras regulation of integrin function. (2001) (15)
Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins. (2016) (15)
Cerebral Cavernous Malformation (2021) (14)
Talin phosphorylation sites mapped by mass spectrometry. (2005) (14)
Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes (2017) (14)
TOTAL CHEMICAL SYNTHESIS OF A FOLDED BETA -SANDWICH PROTEIN DOMAIN : AN ANALOG OF THE TENTH FIBRONECTIN TYPE 3 MODULE (1994) (14)
Platelets and the adhesion receptor superfamily. (1988) (14)
CD98hc (SLC3A2) Interaction with (cid:1) 1 Integrins Is Required for Transformation* (2004) (13)
Platelets and Response to Injury (1998) (13)
CD 98 hc ( SLC 3 A 2 ) participates in fi bronectin matrix assembly by mediating integrin signaling (2007) (13)
Serum factors releasing serotonin from normal platelets: relation to the manifestations of systemic lupus erythematosus. (1977) (12)
Fibrinogen-endothelial cell interaction in vitro: a pathway mediated by an Arg-Gly-Asp recognition specificity. (1989) (12)
Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling (2020) (12)
Adhesive Ligand Binding to Integrin XXb/ 3 Stimulates Tyrosine Phosphorylation of Novel Protein Substrates before Phosphorylation of pp125 FAK (2002) (11)
Cell adhesion in vascular biology: series introductin. (1996) (11)
Mechanisms of platelet response to monosodium urate crystals. (1979) (11)
Phosphorylation sites in the cerebral cavernous malformations complex (2011) (11)
The platelet fibrinogen receptor (1987) (11)
Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays (2002) (10)
Phospholipase Cϵ Suppresses Integrin Activation* (2006) (10)
Consequences of the interaction of platelet membrane glycoprotein GPIIb-IIIa (alpha IIb beta 3) and its ligands. (1992) (9)
UV-C irradiation disrupts platelet surface disulﬁde bonds and activates the platelet integrin (cid:1) IIb (cid:2) 3 (2008) (9)
RLIP 76 ( RalBP 1 ) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration (2006) (8)
CD 98-mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia (2016) (8)
Mutation of the Cytoplasmic Domain of the Integrin Subunit (1995) (8)
Platelet integrins. (1995) (8)
Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains (2017) (8)
in Human Platelets (1984) (7)
Phosphoprotein Enriched in Astrocytes 15 kDa (PEA-15) Reprograms Growth Factor Signaling by Inhibiting Threonine Phosphorylation of Fibroblast Receptor Substrate 2α (2010) (7)
Protein adsorption to monosodium urate crystals: differential responses of human peripheral blood neutrophils. (1977) (7)
Fibronectin binding to platelets. (1992) (7)
Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25hiFoxP3+ Regulatory T Cells. (2020) (7)
A mutation in the alpha subunit of the platelet integrin alphaIIbbeta3 identifies a novel region important for ligand binding. (1999) (6)
A small molecule inhibitor of alpha4 integrin-dependent cell migration. (2009) (6)
Protein binding to monosodium urate crystals and its effect on platelet degranulation. (1977) (6)
Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism. (2020) (6)
Blockade of platelet GPIIB-IIIA (Integrin alphaII(b)beta(3)) in flowing human blood leads to passivation of prothrombotic surfaces. (2002) (6)
Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations (2020) (5)
Reconstructing integrin activation in vitro. (2013) (5)
A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia (2020) (5)
Signal Transduction: Physical Deformation of the Membrane Activates Integrins (2020) (5)
Fibronectin: A Contender in Platelet Adhesive Functions (1989) (5)
Porphyrin synthesis by cultured lymphocytes. (1972) (4)
Rap1 and its effector KRIT1/CCM1 regulate β-catenin signaling (2010) (4)
Fibrinogen and platelet function. (1985) (4)
Signaling and Platelet Adhesion (1999) (4)
Antithrombotic effects of targeting (cid:1) IIb (cid:2) 3 signaling in platelets (2008) (4)
MARCH Proteins Mediate Responses to Antitumor Antibodies (2020) (4)
IGN523: A Therapeutic Anti-CD98 Antibody With Multiple Mechanisms Of Action Demonstrates Anti-Tumor Efficacy (2013) (3)
Erratum: Long range propagation of conformational changes in integrin α(IIb)β3 (Journal of Biological Chemistry (1993) 268 (23087-23092)) (1994) (3)
Optogenetics-based localization of talin to the plasma membrane promotes activation of β3 integrins (2021) (3)
Endothelial struts enable the generation of large lumenized blood vessels de novo (2021) (3)
Integrin alphaIIb-beta3 transmembrane complex (2009) (3)
Glycosaminoglycans alter the capacity of low density lipoprotein to bind to monosodium urate crystals. (1990) (3)
Analysis of B/W-DNA 16 VH gene expression following DNA-peptide immunization (1997) (3)
The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells (2022) (3)
(cid:98) 1 Integrins Participate in the Hypertrophic Response of Rat Ventricular Myocytes (1998) (2)
Integrin Subunit Stimulates LFA-1 (Integrin L 2)-Dependent T Cell Migration by Augmenting the Activation of Focal Adhesion Kinase/Proline-Rich Tyrosine Kinase-2 (2003) (2)
Platelets and Rheumatic Diseases (2009) (2)
Erratum: Small-molecule synergist of the Wnt/β-catenin signaling pathway (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 18, (7444-7448) DOI: 10.1073/pnas.0702136104) (2007) (2)
Non cell-autonomous effect of astrocytes on cerebral cavernous malformations (2021) (2)
Anti-Thrombotic Effects of Targeting Outside-in αIIbβ3 Signaling in Platelets (2008) (2)
Just a Drop of Blood: Exploration of Shear-Dependent Platelet Adhesion and Activation in Microfluidic Devices. (2007) (2)
Integrin aII& (Platelet GPIIb-IIIa) Recognizes in Fibronectin* (1991) (2)
Calpain cleavage of integrin L cytoplasmic domains 1 (1999) (1)
CD61/ Integrin β3 Ligation Contributes to the Thrombopoietin-Mediated Niche Function of Mouse Hematopoietic Stem Cells. (2009) (1)
The Ins and Outs of Integrin Signaling (2008) (1)
Expression cloning strategies for the identification of adhesion molecules. (2002) (1)
On the Yellow Brick Road to Platelet GP IIb-IIIa (Integrin αIIbβ3) Activation. (2006) (1)
Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs (2021) (1)
Recruitment of kindlin‐3 to plasma membrane through its PH domain precedes high affinity β2 integrin activation and neutrophil arrest (2020) (1)
PLATELETS AND THROMBOPOIESIS ADAP interactions with talin and kindlin promote platelet integrin a IIb b 3 activation and stable fi brinogen binding (2014) (1)
[Multimeric structure of factor VIII/von Willebrand factor released from human platelets by ADP, collagen and thrombin]. (1983) (1)
β1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations (2022) (1)
Faculty Opinions recommendation of Kindlin-2 controls bidirectional signaling of integrins. (2008) (0)
United States Patent ( 19 ) Charo et al . 54 PEPTIDES DERIVED FROM GPA ( 75 ) Inventors : Israel (2017) (0)
United States Patent ( 19 ) Charo et al . 54 PEPTIDES DERIVED FROM GPA ( 75 ) Inventors : Israel (2017) (0)
Interactions of platelet integrin (cid:1) (cid:2)(cid:2) b and (cid:3) 3 transmembrane domains in mammalian cell membranes and their role in integrin activation (2009) (0)
PEA-15 regulates integrin function by binding to ERK MAP kinase (2002) (0)
Platelet-Collagen Adhesion" Inhibition Antibody That Binds Glycoprotein lib (2003) (0)
Integrin activation controls regulatory T cell identity and stability (2016) (0)
Abstract 64: Novel and Known Genes Elucidated in Cerebral Cavernous Malformation Through Comparative Transcriptomic Analysis of Multiple Model Species and Human Microdissected Lesional Endothelial Cells (2019) (0)
Expression Cloning of Proteins That Modify Integrin Activation (2019) (0)
ARG-GLY-ASP (RGD) PEPTIDES INCREASE THE EXPOSURE OF THE CARBOXYL TERMINAL REGION OF THE HEAVY CHAIN OF GPIIB ON THE PLATELET SURFACE (1987) (0)
Crystal structure of the KRIT1/CCM1 FERM domain in complex with the heart of glass (HEG1) cytoplasmic tail (2012) (0)
Transmembrane Structure of the Cytokine Receptor Common Subunit beta (2016) (0)
Release ofPlatelet Constituents by MonosodiumUrateCrystals (1977) (0)
Peptides and antibodies that prevent binding of platelets. (1988) (0)
PEA-15 interaction with ERK is mediated via its DED and C-terminal domains (2002) (0)
Investigating PEA‐15's ability to regulate ERK1/2 MAP Kinase activation (2009) (0)
Porphyrin Synthesis by Cultured Lymphocytes 568 Blood (2005) (0)
RECOGNITION SPECIFICITY OFADHESION RECEPTORS (1987) (0)
IntegrinTyrosinePhosphorylationIsaConservedMechanism forRegulatingTalin-inducedIntegrinActivation *□ (2009) (0)
Molecular mechanisms of gouty arthritis: new insights into an old disease. (1984) (0)
Protocols to examine integrin binding with Talin and protocol to test integrin activation by talin (2010) (0)
Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609 (2017) (0)
Abstract 126: Phenotypic Features of Murine Models of Cerebral Cavernous Malformations (2017) (0)
Abstract P737: Human Homologs Of Differentially Expressed Plasma MicroRNAs In Preclinical Murine Models Target Fundamental Mechanisms Of Cerebral Cavernous Malformation (2021) (0)
Cell-to-cell contact and extracellular matrix. (2008) (0)
Endothelial struts, a mechanism to generate large lumenized blood vessels de novo (2019) (0)
A Crucial Role for Caspase 1 in Thrombo-Inflammatory Microparticle Release (2014) (0)
Tuning tumor immunity through integrin transregulation (P5077) (2013) (0)
CD98hc Enables B cell Clonal Expansion and Adaptive Humoral Immunity (94.11) (2009) (0)
Platelet lntegrins (1995) (0)
-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the (cid:1) 4 -cytoplasmic domain (2005) (0)
Identification and molecular cloning of a cytoplasmic antigen utilising selected myasthenic sera (1990) (0)
Crystal structure of an integrin beta3-talin chimera (2003) (0)
Faculty Opinions recommendation of Kindlin-3 disrupts an intersubunit association in the integrin LFA1 to trigger positive feedback activation by Rap1 and talin1. (2021) (0)
Differential Use of Rap1 Effectors for Integrin Activation in Platelets and Lymphocytes (2020) (0)
Hgpiib fragments and their use in procedures that allow the in vitro determination of thrombotic events in vivo. (1992) (0)
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin (cid:2) IIb (cid:3) 3 (2008) (0)
Binding of Fibronectin to o -Granule-deficient Platelets (2002) (0)
High Affinity Bent β2 Integrin Binds Ligand in Cis and Regulates Inflammation (2016) (0)
hGPIIb FRAGMENTS AND THEIR USE IN IN VITRO METHOD FOR DETERMINING IN VIVO held thrombotic events (1992) (0)
Loss of T cell CD98hc specifically ablates T cell clonal expansion and protects from autoimmunity. (102.16) (2011) (0)
Decision letter: Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2 (2019) (0)
5114842 Peptides and antibodies that inhibit platelet adhesion (1993) (0)
Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) (2003) (0)
Faculty Opinions recommendation of Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases. (2003) (0)
Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609 (2017) (0)
Crystal structure of anti-alphaVbeta3 integrin Fab LM609 (2017) (0)
The T Cell Receptor SLAPs Integrins Together (2001) (0)
Bicelle-embedded integrin beta3 transmembrane segment (2008) (0)
Lymphocyte Migration Governs 1 b 4 a The Affinity of Integrin (2001) (0)
Measurements of thrombospondin levels in plasma platelets and urine in humans (1986) (0)
Kindlin‐3 organizes a ring of clustered high affinity β2 integrins during human neutrophil spreading under flow (2020) (0)
Thrombasthenic Platelets Do Not Bind Plasma Fibronectin (1981) (0)
Faculty Opinions recommendation of GPR68 senses flow and is essential for vascular physiology. (2018) (0)
Thrombosis and Inflammation Are Coupled by a Common Thioredoxin Reductase Pathway Downstream of the P2×7 Receptor. (2012) (0)
Abstract 121: Transcriptome Profiling of Laser-Capture Microdissected Endothelial Cells From Human Cerebral Cavernous Malformations (2017) (0)
hGPIIb fragments and their use in in vitro methods for determining in vivo thrombotic conditions (1992) (0)
Peptides and antibodies for inhibiting platelet adhesion (1989) (0)
Crystal structure of a FERM domain of Talin (2003) (0)
Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail (2009) (0)
A Rap1 binding site and lipid-dependent helix in talin F1 domain cooperate in integrin activation (2018) (0)
Abstract TMP1: Multi-omic Biomarker Development In A Mendelian Neurovascular Disease, Cavernous Angioma (2022) (0)
LOCALIZATION AND CHEMICAL SYNTHESIS OF A DIVALENT CATION REGULATED EPITOPE IN PLATELET MEMBRANE GPIIb (1987) (0)
Abstract 70: P2X7-Induced Thiol-Disulfide Exchange is Critical for the Coupling of Coagulation and Inflammation. (2013) (0)
Faculty Opinions recommendation of The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. (2005) (0)
Distinct Roles for Talin-1 and Kindlin-3 in Regulating LFA-1 Conformation during Neutrophil Rolling and Arrest (2012) (0)
Phosphorylation of alpha4 integrin by PKA is required for endothelial cell alignment induced by shear stress (2007) (0)
Transmembrane Structure of the P441A Mutant of the Cytokine Receptor Common Subunit beta (2016) (0)
regulation Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity (2012) (0)
UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin αΠbβ3. Commentary (2008) (0)
Open Research Online Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice (2022) (0)
Kindlin‐3 recruitment to the plasma membrane in neutrophils precedes high affinity integrin activation (2019) (0)
Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease. (2022) (0)
Affinity Modulation of Platelet Integrin a IIb b 3 by b 3-Endonexin , a Selective Binding Partner of the b 3 Integrin Cytoplasmic Tail (1997) (0)
COMMENTARY Integrin cytoplasmic domain-binding proteins (2000) (0)
Targeting of single-chain urokinase-type plasminogen activator with monoclonal antiplatelet antibodies (1990) (0)
Faculty Opinions recommendation of New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain. (2022) (0)
Faculty Opinions recommendation of Adhering to adhesion: assessing integrin conformation to monitor T cells. (2019) (0)
Integrin (cid:2) 4 (cid:3) 1 Promotes Focal Adhesion Kinase-Independent Cell Motility via (cid:2) 4 Cytoplasmic Domain-Speciﬁc Activation of c-Src‡ (2005) (0)
Faculty Opinions recommendation of Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. (2002) (0)
Process for preparing antibodies that inhibit the binding of integrin-ligand. (1989) (0)
Hybridomas producing a receptor that immunoreacts with thrombospondin, such receptors, a diagnostic site-specific imaging comprising such receptors in vitro method for the detection and distinction between stimulated (1986) (0)
Integrin (cid:1) 4 (cid:2) 1 -dependent T Cell Migration Requires Both Phosphorylation and Dephosphorylation of the (cid:1) 4 Cytoplasmic Domain to Regulate the Reversible Binding of Paxillin* (2003) (0)

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