Mark L. Kahn
#142,581
Most Influential Person Now
American cardiologist
Mark L. Kahn's AcademicInfluence.com Rankings
Mark L. Kahnmedical Degrees
Medical
#3507
World Rank
#3978
Historical Rank
Cardiology
#379
World Rank
#390
Historical Rank
Mark L. Kahnphilosophy Degrees
Philosophy
#10947
World Rank
#15023
Historical Rank
Logic
#7810
World Rank
#9695
Historical Rank
Download Badge
Medical Philosophy
Mark L. Kahn's Degrees
- Doctorate Medicine Harvard University
- PhD Cardiology Harvard University
Why Is Mark L. Kahn Influential?
(Suggest an Edit or Addition)According to Wikipedia, Mark L. Kahn is a cardiologist currently serving as the Edward S. Cooper, M.D./Norman Roosevelt and Elizabeth Meriwether McLure Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania. At Penn, Kahn additionally serves as Director of Center for Vascular Biology and Director of Molecular Cardiology.
Mark L. Kahn's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A dual thrombin receptor system for platelet activation (1998) (1023)
- Protease-activated receptor 3 is a second thrombin receptor in humans (1997) (888)
- Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (1999) (838)
- Role of the thrombin receptor in development and evidence for a second receptor (1996) (527)
- Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. (1996) (460)
- Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk (2003) (422)
- Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. (2010) (404)
- Delayed Onset of Inflammation in Protease-Activated Receptor-2-Deficient Mice1 (2000) (291)
- Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2 (2013) (278)
- Klf2 is an essential regulator of vascular hemodynamic forces in vivo. (2006) (265)
- Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2 (2012) (260)
- Platelet ITAM signaling is critical for vascular integrity in inflammation. (2013) (234)
- Protease activated receptors: theme and variations (2001) (222)
- Endothelial TLR4 and the microbiome drive cerebral cavernous malformations (2017) (210)
- Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling (2016) (203)
- Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns (2008) (182)
- Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. (2014) (175)
- Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. (2004) (170)
- Genetic Evidence That Protease-activated Receptors Mediate Factor Xa Signaling in Endothelial Cells* (2002) (165)
- Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation (2018) (155)
- The Platelet Receptor GPVI Mediates Both Adhesion and Signaling Responses to Collagen in a Receptor Density-dependent Fashion* (2002) (152)
- Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear‐resistance of platelet aggregates (2008) (152)
- GPVI and α2β1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow (2005) (151)
- Platelet integrins and immunoreceptors (2007) (149)
- CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. (2010) (147)
- Regulation of cardiovascular development and integrity by the Heart of Glass-Cerebral Cavernous Malformation pathway (2009) (141)
- Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface. (2004) (141)
- Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. (2006) (131)
- Lymph flow regulates collecting lymphatic vessel maturation in vivo. (2015) (129)
- The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. (2015) (127)
- Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. (2006) (120)
- Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation. (2001) (120)
- The Endothelial Cell-Specific Antibody PAL-E Identifies a Secreted Form of Vimentin in the Blood Vasculature (2004) (110)
- Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets (2004) (109)
- Reciprocal Signaling by Integrin and Nonintegrin Receptors during Collagen Activation of Platelets (2003) (108)
- Gene and Locus Structure and Chromosomal Localization of the Protease-activated Receptor Gene Family* (1998) (107)
- Lipid Rafts Orchestrate Signaling by the Platelet Receptor Glycoprotein VI* (2002) (106)
- Corrigendum: Regulation of cardiovascular development and integrity by the heart of glass– cerebral cavernous malformation protein pathway (2009) (106)
- Neutrophil accumulation and NET release contribute to thrombosis in HIT. (2018) (99)
- B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2 (2010) (97)
- Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. (1999) (97)
- Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves (2016) (96)
- Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. (2016) (92)
- Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis. (2017) (91)
- Evidence for the Requirement of ITAM Domains but Not SLP-76/Gads Interaction for Integrin Signaling in Hematopoietic Cells (2006) (90)
- Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa. (2008) (84)
- Expression of the Platelet Receptor GPVI Confers Signaling via the Fc Receptor γ-Chain in Response to the Snake Venom Convulxin but Not to Collagen* (2001) (84)
- Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets. (2003) (83)
- Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism (2009) (82)
- Platelets: covert regulators of lymphatic development. (2010) (75)
- Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents. (2006) (72)
- GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. (2005) (71)
- Blood flow reprograms lymphatic vessels to blood vessels. (2012) (67)
- Platelet-collagen responses: molecular basis and therapeutic promise. (2004) (66)
- Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role (2009) (64)
- Distinct Pathways Regulate Syk Protein Activation Downstream of Immune Tyrosine Activation Motif (ITAM) and hemITAM Receptors in Platelets* (2015) (64)
- PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism (2021) (62)
- Platelet Immunoreceptor Tyrosine-Based Activation Motif (ITAM) Signaling and Vascular Integrity (2014) (62)
- Lymphatic function is required prenatally for lung inflation at birth (2014) (58)
- Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. (2012) (56)
- Ligand Binding Rapidly Induces Disulfide-dependent Dimerization of Glycoprotein VI on the Platelet Plasma Membrane* (2007) (55)
- Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets. (2007) (55)
- Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage. (2019) (54)
- Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease. (2011) (54)
- Optimization of retroviral vector-mediated gene transfer into endothelial cells in vitro. (1992) (52)
- In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. (2006) (51)
- Platelets and tumor cells: a new form of border control. (2013) (51)
- Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation (2019) (43)
- Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo (2008) (40)
- Fc Rγ-independent Signaling by the Platelet Collagen Receptor Glycoprotein VI* (2003) (38)
- Familial Cerebral Cavernous Malformations (2019) (36)
- A rationale for blocking thromboinflammation in COVID-19 with Btk inhibitors (2020) (35)
- Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation. (2016) (35)
- Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site (2013) (35)
- Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes. (2019) (32)
- The Transcription Factor Atonal homolog 8 Regulates Gata4 and Friend of Gata-2 during Vertebrate Development (2013) (31)
- Specific Inhibition Of Ectodomain Shedding Of GPIba By Targeting Its Shedding Cleavage Site (2013) (31)
- Expression of an anchored urokinase in the apical endothelial cell membrane. Preservation of enzymatic activity and enhancement of cell surface plasminogen activation. (1992) (31)
- Atypical cadherin Fat4 orchestrates lymphatic endothelial cell polarity in response to flow. (2020) (27)
- Initial experience with percutaneous placement of the PAS port implantable venous access device. (1992) (27)
- The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. (2013) (26)
- Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC. (2019) (26)
- Negative regulation of activated alpha-2 integrins during thrombopoiesis. (2009) (25)
- Corrigendum: Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling (2016) (25)
- Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis. (2019) (25)
- Phenotypic Characterization of Murine Models of Cerebral Cavernous Malformations (2017) (24)
- Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations (2019) (24)
- Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease (2016) (24)
- Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling. (2019) (24)
- Experience with the P.A.S.-PORT venous access device in patients with gynecologic malignancies. (1996) (23)
- Blood is thicker than lymph. (2008) (23)
- Doppler echocardiography and computed tomography in diagnosis of left coronary arteriovenous fistula. (1984) (22)
- Density of platelet collagen receptors glycoprotein VI and α2β1 and prior myocardial infarction in human subjects, a pilot study (2005) (22)
- Biomarkers of cavernous angioma with symptomatic hemorrhage. (2019) (22)
- Cerebral Cavernous Malformations Arise Independent of the Heart of Glass Receptor (2014) (21)
- Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican (2020) (20)
- High-resolution echocardiographic assessment of infarct size and cardiac function in mice with myocardial infarction. (2011) (20)
- Platelet Receptor Glycoprotein VI-Mediated Adhesion to Type I Collagen Under Hydrodynamic Flow (2004) (19)
- Density of platelet collagen receptors glycoprotein VI and alpha2beta1 and prior myocardial infarction in human subjects, a pilot study. (2005) (19)
- Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma (2020) (19)
- Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment (2020) (17)
- Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency. Commentary (2006) (16)
- Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation (2022) (15)
- CCM 3 signaling through sterile 20 – like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations (2010) (15)
- Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction. (2021) (14)
- Cerebral Cavernous Malformation (2021) (14)
- Measurement of platelet collagen receptor density in human subjects. (2004) (13)
- Fc Rgamma -independent signaling by the platelet collagen receptor glycoprotein VI. (2003) (13)
- Cell Adhesion Mediated by VCAM–ITG&agr;9 Interactions Enables Lymphatic Development (2015) (13)
- Donor-host Lymphatic Anastomosis After Murine Lung Transplantation (2020) (12)
- Novel Platelet and Vascular Roles for Immunoreceptor Signaling (2006) (11)
- Electron beam coronary angiography to assess patency in the off-pump coronary bypass graft. (2002) (9)
- adhesion and aggregate formation to collagen under flow GPVI and { alpha } 2 { beta } 1 play independent critical roles during platelet (2005) (9)
- Developmental venous anomalies are a genetic primer for cerebral cavernous malformations (2021) (9)
- Integrins and ITAMs: more than just good neighbors (2006) (9)
- Lymphatics as a new active player in reverse cholesterol transport. (2013) (7)
- Counteracting clotting in sepsis (2008) (7)
- Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth (2020) (7)
- Control of clot lysis by gene transfer. (1993) (6)
- The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK 3 Signaling and KLF Expression Graphical (2015) (5)
- A critical role of platelet glycoprotein Ibα in arterial remodeling. (2015) (5)
- HA-ving lymphatics improves lung transplantation. (2015) (4)
- regulation by cytoplasmic tyrosines 1 integrin function requires phosphorylation-independent β In vivo Material Supplemental (2006) (3)
- Separation of blood and lymphatic vascular networks is regulated by the hematopoietic signaling proteins SLP-76 and Syk. (2002) (3)
- SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice (2021) (3)
- Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis. (2022) (3)
- Simon nitinol vena cava filter: preliminary observations and suggested procedural modifications. (1991) (3)
- Platelet collagen receptors play molecular ping-pong (2004) (2)
- Perspectives on Cognitive Phenotypes and Models of Vascular Disease. (2022) (2)
- Mouse placenta fetal macrophages arise from endothelial cells outside the placenta. (2022) (2)
- Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: De-ITAM-ising FcγRIIa Running Title: Platelet receptor regulation (2013) (2)
- Platelet integrin signaling: wherefore art thou? (2009) (2)
- Sinusoidal and lymphatic vessel growth is controlled by reciprocal VEGF-C–CDH5 inhibition (2022) (2)
- Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice (2022) (2)
- Platelet ITAM Signaling and Vascular Integrity (2014) (2)
- VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development (2022) (2)
- Vascular development for climate control. (2015) (1)
- Platelet collagen receptor glycoprotein VI as a novel risk factor for myocardial infarction (2003) (1)
- Why Don't Cerebral Cavernous Malformations Go With the Flow? (2019) (1)
- Erratum: Blood flow reprograms lymphatic vessels to blood vessels (Journal of Clinical Investigation (2012) 122, 6 (2006-2017) DOI: 10.1172/JCI57513) (2012) (1)
- A Molecular Pathway for Arterial-Specific Association of Vascular Smooth Muscle Cells (2019) (1)
- BLOOD-LYMPHATIC VESSEL INTEGRITY REQUIRES SYK TYROSINE KINASE SIGNALING WITHIN THE ENDOTHELIAL CELL COMPARTMENT (2004) (1)
- The cerebral cavernous malformation pathway controls embryonic endocardial gene expression through regulation of MEKK3 signaling and KLF expression (2015) (1)
- Rapamycin in Cerebral Cavernous Malformations: What Doses to Test in Mice and Humans. (2022) (1)
- outside-in signaling pathways in platelets 3 integrin inside-out and β Structure-function analysis reveals discrete (2013) (1)
- Results VCAM and Fibronectin Are Expressed Along the Path of Lymphatic Endothelial Growth in the Developing Intestine (0)
- Abstract P737: Human Homologs Of Differentially Expressed Plasma MicroRNAs In Preclinical Murine Models Target Fundamental Mechanisms Of Cerebral Cavernous Malformation (2021) (0)
- Inflammation and Lymphoid Neogenesis Induced by Deletion of Lymphatics in Healed Lung Isografts Show the Importance of Lymphatics in Lung Homeostasis and Function (2018) (0)
- Abstract 126: Phenotypic Features of Murine Models of Cerebral Cavernous Malformations (2017) (0)
- Microbiome Regulation of Toll-Like Receptor Signaling and Vascular Malformation (2020) (0)
- ATVB in Focus Platelets Unplugged: Focus on Platelet Biology (2010) (0)
- 841-5 Attenuation of human atherosclerotic plaque inflammation by PPAR-γ agonist and NF-κB inhibitor (2004) (0)
- and aggregation Platelet glycoprotein V binds to collagen and participates in platelet adhesion (2013) (0)
- outside-in signaling pathways in platelets Structure-function analysis reveals discrete ß3 integrin inside-out and (2010) (0)
- Sequencing and Quantitative Multiplex Polymerase Chain Reaction of Short Fluorescent Fragment Analysis (2014) (0)
- A BMPy Road for Venous Development. (2017) (0)
- Defects In Vein Valve PROX1/FOXC2 Antithrombotic Pathway in Endothelial Cells Drive the Hypercoagulable State Induced by Trauma and Critical Illness. (2023) (0)
- Role of Flow in Lymphatic Vessel Remodeling and Patterning (2015) (0)
- Movie S7. Time-Lapse Imaging Shows the Interaction of WT DCs with Pdpn−/− FRCs Cultured in 3D Matrix (2012) (0)
- Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment (2020) (0)
- Platelet Activation and the Formation of the Platelet Plug Series (2006) (0)
- Movie S4. Time-Lapse Imaging Shows DCs Approaching Branched FRCs in 3D Matrix (2012) (0)
- Movie S2. Confocal Time-Lapse Imaging of DC Motility in LN Slices from WT BM → Ub-GFP Mice (2012) (0)
- Abstract 64: Novel and Known Genes Elucidated in Cerebral Cavernous Malformation Through Comparative Transcriptomic Analysis of Multiple Model Species and Human Microdissected Lesional Endothelial Cells (2019) (0)
- Movie S6. Time-Lapse Imaging Shows the Interaction of Clec1b−/− DCs with WT FRCs Cultured in 3D Matrix (2012) (0)
- Platelets in Thrombotic and Non-thrombotic Disorders: Platelet receptors for thrombin (2002) (0)
- Decision letter: Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation (2020) (0)
- Platelet Immunoreceptor Tyrosine-Based Activation Motif Signaling in Hemostasis and Thrombosis (2014) (0)
- Limitations to Understanding Intestinal Stem Cell Activity via Cre-Lox–Based Lineage Tracing (2022) (0)
- platelet receptors: de-ITAM-izing Fc Dual ITAM-mediated proteolytic pathways for irreversible inactivation of (2013) (0)
- Lymphatic Thrombosis and Impaired Lymph Drainage in Cigarette Smoke-Associated Emphysema (2021) (0)
- Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations (2019) (0)
- PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy. (2023) (0)
- GPVI: no magic bullet for thrombosis (2006) (0)
- GEMMs Shine a Light on Resistance to Androgen Deprivation Therapy for Prostate Cancer (2013) (0)
- Crystal structure of human platelet Glycoprotein VI (GPVI) (2007) (0)
- Abstract TMP106: Intestinal Barrier Leakage Exacerbates Cerebral Cavernous Malformation Development in Murine Models (2019) (0)
- Abstract TMP1: Multi-omic Biomarker Development In A Mendelian Neurovascular Disease, Cavernous Angioma (2022) (0)
- No crops without seeds: the risks in declining support for fundamental research (2023) (0)
- Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma (2023) (0)
- Pulmonary Lymphatics Regulate Immune Cell Trafficking and Lung Injury (2019) (0)
- Abstract TMP107: Microbiome Signature of Cerebral Cavernous Malformation Patients (2019) (0)
- Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection (2023) (0)
- Microfluidic Flow Studies of Murine Thrombus Formation and Stability on Collagen. (2008) (0)
- Effect of shear stress on platelet activation via the glycoprotein VI receptor (2002) (0)
- Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma (2020) (0)
- Vascular mimicry by VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development (2022) (0)
- Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease. (2022) (0)
- Erratum: Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells (Journal of Biological Chemistry (2002) 277 (16081-16087)) (2002) (0)
- RAPID LIGAND-INDUCED DIMERIZATION OF PLATELET GLYCOPROTEIN VI (2007) (0)
- Abstract 486: Platelet ITAM Signaling is Critical for Maintenance of Vascular Integrity in Inflammation (2013) (0)
- Investigating Effects of Fluid Shear Stress on Lymphatic Endothelial Cells. (2018) (0)
- Lymphoedema conditions disrupt endothelial barrier function in vitro (2022) (0)
- The novel transmembrane protein, Heart of Glass, is required in the vascular endothelium for normal cardiovascular development and regulation of pulmonary and systemic blood pressure (2014) (0)
- Movie S5. Time-Lapse Imaging Shows the Migration of WT DCs along WT FRCs Cultured in 3D Matrix (2012) (0)
- TCT-655 Outcomes of high-risk patients undergoing percutaneous coronary interventions in the ambulatory versus in-hospital setting (2012) (0)
- Jazzing up vessel growth. (2010) (0)
This paper list is powered by the following services:
Other Resources About Mark L. Kahn
What Schools Are Affiliated With Mark L. Kahn?
Mark L. Kahn is affiliated with the following schools:
