Mark A. Lemmon
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David A. Sackler Professor of Pharmacology at Yale University where he co-directs the Cancer Biology Institute with Joseph Schlessinger
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Why Is Mark A. Lemmon Influential?
(Suggest an Edit or Addition)According to Wikipedia, Mark Andrew Lemmon an English-born biochemist, is the Alfred Gilman Professor and Department Chair of Pharmacology at Yale University where he also directs the Cancer Biology Institute. Education Lemmon was born in Norfolk, England in 1964 and grew up in Taverham and Poringland. He was educated at Norwich School , and then at Hertford College, Oxford, from which he graduated with a first class Bachelor of Arts degree in biochemistry in 1988. He completed his PhD at Yale University as a Howard Hughes Medical Institute Predoctoral Fellow supervised by Donald Engelman for research on the oligomerization of transmembrane α-helices.
Mark A. Lemmon's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cell Signaling by Receptor Tyrosine Kinases (2000) (4184)
- Membrane recognition by phospholipid-binding domains (2008) (1378)
- An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. (2003) (930)
- EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. (2003) (748)
- Signal-dependent membrane targeting by pleckstrin homology (PH) domains. (2000) (723)
- Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation (1994) (637)
- Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain (1995) (599)
- Phosphoinositide Recognition Domains (2003) (569)
- Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. (1995) (563)
- Activation of phospholipase Cγ by PI 3‐kinase‐induced PH domain‐mediated membrane targeting (1998) (548)
- Regulation of signal transduction and signal diversity by receptor oligomerization. (1994) (520)
- Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors? (1995) (497)
- Sequence specificity in the dimerization of transmembrane alpha-helices. (1992) (492)
- ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation (2010) (468)
- PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface (1996) (463)
- Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices. (1992) (457)
- Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains* (1998) (442)
- Two EGF molecules contribute additively to stabilization of the EGFR dimer (1997) (364)
- Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. (2004) (351)
- SH2 and PTB Domains in Tyrosine Kinase Signaling (2003) (344)
- Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. (2000) (342)
- The EGFR family: not so prototypical receptor tyrosine kinases. (2014) (341)
- Identification and analysis of PH domain‐containing targets of phosphatidylinositol 3‐kinase using a novel in vivo assay in yeast (1998) (337)
- Pleckstrin homology (PH) domains and phosphoinositides. (2007) (331)
- The Single Transmembrane Domains of ErbB Receptors Self-associate in Cell Membranes* (2002) (317)
- Svp1p defines a family of phosphatidylinositol 3,5‐bisphosphate effectors (2004) (315)
- ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma. (2014) (292)
- The juxtamembrane region of the EGF receptor functions as an activation domain. (2009) (292)
- Epidermal Growth Factor Receptor Dimerization and Activation Require Ligand-Induced Conformational Changes in the Dimer Interface (2005) (272)
- Pleckstrin homology domains and the cytoskeleton (2002) (271)
- A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV‐1 Nef protein. (1995) (270)
- Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin (1994) (266)
- Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation (1998) (256)
- Identification of the binding site for acidic phospholipids on the pH domain of dynamin: implications for stimulation of GTPase activity. (1996) (253)
- A dimerization motif for transmembrane α–helices (1994) (250)
- Functional selectivity of EGF family peptide growth factors: implications for cancer. (2009) (248)
- Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal. (1995) (239)
- Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. (2006) (228)
- Pleckstrin homology domains: not just for phosphoinositides. (2004) (228)
- Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma (2011) (223)
- Ligand-induced ErbB receptor dimerization. (2009) (223)
- The Pleckstrin Homology Domains of Dynamin Isoforms Require Oligomerization for High Affinity Phosphoinositide Binding* (1998) (202)
- Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. (2010) (202)
- EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics (2017) (201)
- All Phox Homology (PX) Domains from Saccharomyces cerevisiae Specifically Recognize Phosphatidylinositol 3-Phosphate* (2001) (195)
- Mechanism of activation and inhibition of the HER4/ErbB4 kinase. (2008) (176)
- Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor (2010) (174)
- The glycophorin A transmembrane domain dimer: sequence-specific propensity for a right-handed supercoil of helices. (1992) (172)
- Structural organization of the pentameric transmembrane alpha‐helices of phospholamban, a cardiac ion channel. (1994) (167)
- Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. (1998) (167)
- ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface (2004) (164)
- Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids (2010) (154)
- Conditional peripheral membrane proteins: facing up to limited specificity. (2012) (151)
- Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain (2012) (150)
- Argos inhibits epidermal growth factor receptor signalling by ligand sequestration (2004) (150)
- Extracellular domains drive homo‐ but not hetero‐dimerization of erbB receptors (2000) (150)
- Specificity and promiscuity in membrane helix interactions (1994) (143)
- Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains (1997) (133)
- Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling (2018) (133)
- A structure-based model for ligand binding and dimerization of EGF receptors. (2004) (133)
- The ALK/ROS1 Inhibitor PF-06463922 Overcomes Primary Resistance to Crizotinib in ALK-Driven Neuroblastoma. (2016) (132)
- Determining selectivity of phosphoinositide-binding domains. (2006) (131)
- Normalization of nomenclature for peptide motifs as ligands of modular protein domains (2002) (130)
- Pleckstrin homology domains. (1998) (124)
- Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. (2006) (123)
- Kit Receptor Dimerization Is Driven by Bivalent Binding of Stem Cell Factor* (1997) (118)
- Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB (2004) (117)
- Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study (2009) (116)
- Dominant-negative inhibition of receptor-mediated endocytosis by a dynamin-1 mutant with a defective pleckstrin homology domain (1999) (116)
- A dimerization motif for transmembrane alpha-helices. (1994) (115)
- Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides. (2001) (115)
- On the nature of low- and high-affinity EGF receptors on living cells. (2006) (113)
- Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients (2010) (113)
- Mechanism for activation of mutated epidermal growth factor receptors in lung cancer (2013) (113)
- The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function. (2004) (111)
- Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond. (1994) (105)
- Ligand-induced structural transitions in ErbB receptor extracellular domains. (2007) (102)
- N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils* (2009) (101)
- Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae (2009) (96)
- Essential Role for Rac in Heregulin β1 Mitogenic Signaling: a Mechanism That Involves Epidermal Growth Factor Receptor and Is Independent of ErbB4 (2006) (96)
- Nuclear Signaling by Receptor Tyrosine Kinases: The First Robin of Spring (2006) (93)
- ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor (2009) (92)
- TIPE3 is the transfer protein of lipid second messengers that promote cancer. (2014) (92)
- Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins* (2001) (89)
- The Dark Side of Cell Signaling: Positive Roles for Negative Regulators (2016) (89)
- Specificity and promiscuity in membrane helix interactions (1994) (88)
- Modulation of cardiac PIP2 by cardioactive hormones and other physiologically relevant interventions. (2002) (85)
- Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy. (1995) (85)
- Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation (1997) (84)
- EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer (2007) (84)
- Faculty Opinions recommendation of Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. (2005) (84)
- High-affinity binding of a FYVE domain to phosphatidylinositol 3-phosphate requires intact phospholipid but not FYVE domain oligomerization. (2001) (80)
- Specific role for the PH domain of dynamin‐1 in the regulation of rapid endocytosis in adrenal chromaffin cells (1997) (77)
- The Role of the Pleckstrin Homology Domain in Membrane Targeting and Activation of Phospholipase Cβ1 * (2000) (76)
- Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor. (2014) (76)
- Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family (2012) (74)
- Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2. (1994) (72)
- The p21-activated Protein Kinase-related Kinase Cla4 Is a Coincidence Detector of Signaling by Cdc42 and Phosphatidylinositol 4-Phosphate* (2004) (71)
- Receptor tyrosine kinases with intracellular pseudokinase domains. (2013) (71)
- Crystal Structure of Fibroblast Growth Factor 9 Reveals Regions Implicated in Dimerization and Autoinhibition* (2001) (69)
- A possible effector role for the pleckstrin homology (PH) domain of dynamin (2009) (68)
- Loss of Phosphatidylinositol 3-Phosphate Binding by the C-terminal Tiam-1 Pleckstrin Homology Domain Prevents in Vivo Rac1 Activation without Affecting Membrane Targeting* (2003) (67)
- Ala‐insertion scanning mutagenesis of the glycophorin a transmembrane helix: A rapid way to map helix‐helix interactions in integral membrane proteins (1996) (62)
- Scratching the surface with the PH domain (1995) (62)
- Signaling by receptor tyrosine kinases : a subject collection from Cold Spring Harbor perspectives in biology (2014) (60)
- Helix-helix interactions inside lipid bilayers (1992) (58)
- Structural basis for EGFR ligand sequestration by Argos (2008) (53)
- Phosphoinositide Binding by the Pleckstrin Homology Domains of Ipl and Tih1* (2002) (51)
- Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. (2009) (50)
- The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity. (2006) (49)
- Computational analysis of EGFR inhibition by Argos. (2005) (46)
- Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma (2012) (46)
- Putting together structures of epidermal growth factor receptors. (2014) (46)
- Mutations in or near the Transmembrane Domain Alter PMEL Amyloid Formation from Functional to Pathogenic (2011) (45)
- Membrane activity of the phospholipase C-δ1 pleckstrin homology (PH) domain (2005) (45)
- Thermodynamic studies of tyrosyl-phosphopeptide binding to the SH2 domain of p56lck. (1994) (45)
- Pleckstrin Homology Domains: Two Halves Make a Hole? (2005) (40)
- Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases. (2020) (37)
- Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases. (2011) (35)
- Finding the missing links in EGFR (2012) (34)
- Thermodynamic Studies of SHC Phosphotyrosine Interaction Domain Recognition of the NPXpY Motif (*) (1996) (34)
- Comparison of Saccharomyces cerevisiae F-BAR domain structures reveals a conserved inositol phosphate binding site. (2015) (34)
- Transmembrane signaling by receptor oligomerization. (1998) (33)
- Specificity of the Myotubularin Family of Phosphatidylinositol-3-phosphatase Is Determined by the PH/GRAM Domain* (2006) (33)
- Ligand regulation of a constitutively dimeric EGF receptor (2015) (33)
- Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations (2020) (33)
- Faculty Opinions recommendation of Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein. (2005) (33)
- Overcoming Resistance to HER2 Inhibitors Through State-Specific Kinase Binding (2016) (30)
- The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma (2019) (29)
- Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics (2020) (28)
- Dimerization of Tie2 mediated by its membrane-proximal FNIII domains (2017) (26)
- Insulin and epidermal growth factor receptor family members share parallel activation mechanisms (2020) (22)
- Non-acylated Wnts Can Promote Signaling. (2019) (20)
- Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma (2011) (19)
- Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase. (2017) (18)
- The EGF receptor family as therapeutic targets in breast cancer. (2003) (18)
- Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain. (2005) (17)
- Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias (2022) (16)
- Genome-wide analysis of signaling domain function. (2003) (15)
- A New Twist in the Transmembrane Signaling Tool-Kit (2007) (14)
- Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers (2021) (13)
- Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain. (2018) (12)
- Analysis of phosphoinositide binding by pleckstrin homology domain from dynamin. (2001) (12)
- EGFR mutations cause a lethal syndrome of epithelial dysfunction with progeroid features (2015) (12)
- Structural basis for ligand reception by anaplastic lymphoma kinase (2021) (10)
- Protein kinase C regulation: C1 meets C-tail. (2011) (10)
- Phosphatidylserine binding directly regulates TIM-3 function (2021) (9)
- Argos Mutants Define an Affinity Threshold for Spitz Inhibition in Vivo* (2006) (9)
- Occupy EGFR. (2012) (8)
- Computational algorithms for in silico profiling of activating mutations in cancer (2019) (8)
- Structural basis for high-affinity phosphoinositide binding by pleckstrin homology domains. (1999) (8)
- KSR Plays CRAF-ty (2011) (8)
- Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23. (2018) (7)
- Neuregulin Signaling Is a Mechanism of Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma (2019) (6)
- Dimerization of glycophorin A transmembrane helices: mutagenesis and modeling. (1993) (6)
- ErbB2/HER2/Neu resembles an autoinhibited invertebrate EGF receptor (2009) (5)
- ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes (2021) (5)
- Erratum: Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma (Oncogene (2012) 31 (4859-4867) DOI: 10.1038/onc.2011.647) (2012) (5)
- Flipping ATP to AMPlify Kinase Functions (2018) (4)
- Signaling by the sea (2004) (3)
- Analysis of the environmental conditions at Gale Crater from MSL/REMS measurements (2016) (3)
- Smoothening out the patches (2018) (3)
- Deletion Mutations Keep Kinase Inhibitors in the Loop. (2016) (3)
- Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation (2021) (3)
- Simulation of helix association in membranes: modeling the glycophorin A transmembrane domain (1993) (3)
- Looking lively: emerging principles of pseudokinase signaling. (2022) (3)
- Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB. (2020) (2)
- An open-and-shut case (2003) (2)
- Loss of PtdIns-3-P binding by the C-terminal Tiam-1 pleckstrin homology (PH) domain prevents in vivo Rac1 activation without affecting membrane targeting* (2003) (2)
- Chapter 136 – Pleckstrin Homology (PH) Domains (2010) (2)
- Dynamics of protein kinases and pseudokinases by HDX-MS. (2022) (2)
- Helix-helix interactions inside membranes (1995) (2)
- Abstract 1619: The next-generation ALK inhibitor PF-06463922 overcomes primary resistance to crizotinib in neuroblastoma (2015) (1)
- PH Domains: Diverse Sequences with Minireview a Common Fold Recruit Signaling Molecules to the Cell Surface (1996) (1)
- STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE (1996) (1)
- Correction for Brewer et al., Mechanism for activation of mutated epidermal growth factor receptors in lung cancer (2013) (1)
- Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations (2022) (1)
- Allosteric Regulation of the Epidermal Growth Factor Receptor (2014) (1)
- Crystal structure of the EGF receptor juxtamembrane and kinase domains (2009) (1)
- CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9) (2001) (1)
- Computational algorithms for in silico profiling of activating mutations in cancer (2019) (1)
- Tie2 Receptor Dimerization Mediated by its Extracellular FNIII Domains (2013) (1)
- Faculty Opinions recommendation of The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition. (2006) (1)
- The ALK / ROS 1 inhibitor PF-06463922 overcomes primary 1 resistance to crizotinib in ALK-driven neuroblastoma 2 3 (2015) (1)
- Crystal structure of the epidermal growth factor receptor extracellular region in complex with epiregulin (2017) (0)
- STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH (2000) (0)
- Abstract 4685: Mechanistic guidance of ALK inhibition for the treatment of neuroblastoma (2011) (0)
- Structural bases for specific phosphoinositide binding by PH domains (1999) (0)
- STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE (2000) (0)
- Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF. (2003) (0)
- PH domains: diverse sequences with a common membrane association function (1996) (0)
- Bresler Found in Neuroblastoma Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants (2011) (0)
- TITLE : INVESTIGATION OF NOVEL MOLECULAR TARGETS FOR PLECKSTRIN HOMOLOGY ( PH ) DOMAINS FOUND IN ONCOGENES IMPLICATED IN BREAST CANCER PRINCIPAL INVESTIGATOR : (2007) (0)
- Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with trehalose (2021) (0)
- Phosphatidylserine binding regulates TIM-3 effects on T cell receptor signaling (2021) (0)
- Award Number: W81XWH-05-1-0289 TITLE: Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment (2007) (0)
- Auto‐inhibition of dynamin GTPase activity is regulated by PH domain interactions (2009) (0)
- Molecular Determinants of tGolgin-1 Function (2003) (0)
- CHAPTER 150 – Pleckstrin Homology (PH) Domains (2003) (0)
- Crystal structure of EGFR tyrosine kinase domain with novel inhibitor of active state of HER2 (2016) (0)
- Characterization of Novel PtdIns(4,5)P2 Effector Domains (2009) (0)
- Understanding Kinase Activation of ALK in Neuroblastoma Patients (2013) (0)
- Crystal structure of the Drosophila Epidermal Growth Factor Receptor ectodomain complexed with a low affinity Spitz mutant (2010) (0)
- Structure of the Kinase Associated-1 (KA1) from Kcc4p (2010) (0)
- Abstract 1106: Mechanism for activation of mutated EGF receptors in lung cancer. (2013) (0)
- Study of the Regulation of ErbB Signaling by Receptor-Mediated Endocytosis (2001) (0)
- Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases (2021) (0)
- Only one of the 33 Saccharomyces cerevisiae PH domains binds specifically to phosphoinositides (2004) (0)
- Crystal structure of the inactive TrkA kinase domain (2012) (0)
- Faculty Opinions recommendation of ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes. (2006) (0)
- Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP (2010) (0)
- 210 Regulation of TIM-3 by phosphatidylserine (2020) (0)
- Glioblastoma mutations impair ligand discrimination by EGFR (2021) (0)
- Efficacy of osimertinib in patients with lung cancer positive for uncommon EGFR exon 19 deletion mutations. (2023) (0)
- Faculty Opinions recommendation of GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. (2006) (0)
- 4558 Investigating the functional consequences of anaplastic lymphoma kinase (ALK) mutations arising upon Lorlatinib treatment (2020) (0)
- Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib (2012) (0)
- Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma. (2023) (0)
- Faculty Opinions recommendation of A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. (2005) (0)
- Conserved Hydrophobic and Hydrophilic Bond Interaction Networks in ErbB Family Kinases (2010) (0)
- Mechanism of ErbB1 and ErbB2 Hetero-Oligomerization (2002) (0)
- Regulation of kinase activity in the C. elegans EGF receptor, LET-23 (2018) (0)
- Abstract 3904: Overcoming resistance to HER2 inhibitors through cell based screening (2016) (0)
- The Role of Dynamin in the Regulation of Signaling by the erbB Family of Receptor Kinases (2004) (0)
- Structure of the Kinase Associated Domain-1 (KA1) from Kcc4p (2010) (0)
- Mice Lacking Pleckstrin or Pleckstrin-2 Each Have Unique Platelet Secretion Defects. (2007) (0)
- Structure of unliganded, inactive PTK7 kinase domain (2012) (0)
- Regulation of the epidermal growth factor receptor intracellular domain (2009) (0)
- Phosphoinositide‐mimicking peptide sequences are binding targets for PH domains (2009) (0)
- Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin (2021) (0)
- Knockout of the PKC Substrate Pleckstrin Causes Pleomorphic Defects in Platelets, Lymphocytes and Granulocytes. (2006) (0)
- Normalization of Nomenclature for Functional Peptide Motifs as Ligands of Modular Protein Domains (2002) (0)
- Crystal Structure of unliganded Argos (2008) (0)
- Crystal structure of the membrane proximal three fibronectin type III (FNIII) domains of Tie2 (Tie2[FNIIIa-c]) (2017) (0)
- X-Ray Diffraction data from human Tie2 FNIII domains, source of 5UTK structure (2017) (0)
- Rapid Visual Assays of Oncogenic Aberrant ErbB Receptor activation Using Fluorescence Microscopy (2002) (0)
- Abstract PO032: TIM3 regulation by phosphatidylserine (2021) (0)
- Development of Strategies to Manipulate ErbB Receptor Heterodimerization from a Quantitative Analysis of Receptor/Ligand Relationships (1999) (0)
- A Prosperous Future. (2022) (0)
- Structure of the Kinase Associated Domain 1 (KA1) from MARK1 kinase (2010) (0)
- High Resolution Crystal Structure of the EGF domain of Spitz (2008) (0)
- Crystal Structure of Hof1p F-BAR domain (2014) (0)
- Activation and Inhibition of the EGF Receptor (2007) (0)
- The Role of Dynamin in the Regulation of Signaling by the erbB Family of Receptor Tyrosine Kinases (0)
- Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes (2023) (0)
- Structure of the extracellular WNT-binding module in Drosophila Ror2/Nrk (2021) (0)
- Analysis of Ligand Binding ErbB Receptor Tyrosine Kinases (2000) (0)
- Crystal structure of Rgd1p F-BAR domain in complex with inositol phosphate (2014) (0)
- Crystal structure of the unliganded Drosophila Epidermal Growth Factor Receptor ectodomain (2009) (0)
- Faculty Opinions recommendation of Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. (2004) (0)
- Genomes & Developmental Control Computational analysis of EGFR inhibition by Argos (2005) (0)
- High Resolution Crystal Structure of Argos bound to the EGF domain of Spitz (2008) (0)
- Award Number : DAMD 17-011-0370 TITLE : Mechanism of ErbBl and ErbB 2 Hetero-oligomerization PRINCIPAL INVESTIGATOR : (0)
- Molecular determinants within pleckstrin homology (PH) domains that allow for specific recognition of phosphoinositides (2001) (0)
- Structure of the extracellular WNT-binding module in Drl-2 (2021) (0)
- Interim Results of the Effect of Haptoglobin Phenotype on Inflammatory Cytokine Concentrations in Plasma and CSF After Aneurysmal Subarachnoid Hemorrhage (2020) (0)
- Complex Relationship bet ween Ligand Binding and Dimerization in the Epidermal Growth Factor Receptor Graphical (2014) (0)
- Harnessing Novel Secreted Inhibitors of EGF Receptor Signaling for Breast Cancer Treatment (2006) (0)
- MOLECULAR-CELL-D-20-00113 "Structural insights into pseudokinase domains of receptor tyrosine kinases" Sheetz et al. (2020) (0)
- Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz (2010) (0)
- Predicting the Effects of Clinically Observed Kinase Mutations using Molecular Modeling and Machine Learning Algorithms (2015) (0)
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