Mark R. Denison
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Pediatrician
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Mark R. Denison's Degrees
- Doctorate Medicine Vanderbilt University
- Bachelors Biology Duke University
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Why Is Mark R. Denison Influential?
(Suggest an Edit or Addition)According to Wikipedia, Mark R. Denison is the Stahlman Professor of Pediatrics, Pathology, Microbiology & Immunology and director of the Division of Pediatric Infectious Diseases at Vanderbilt University Medical Center. Denison has been researching the replication, pathogenesis and evolution of coronaviruses for over 30 years, and has published his research on SARS-CoV, MERS-CoV, and the current SARS-CoV-2.
Mark R. Denison's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- An mRNA Vaccine against SARS-CoV-2 — Preliminary Report (2020) (2366)
- Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) (1524)
- Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses (2017) (1328)
- Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease (2018) (1198)
- Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults (2020) (1020)
- SARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness (2020) (846)
- Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen (2017) (837)
- An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice (2020) (752)
- Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination (2020) (613)
- Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus (2011) (530)
- Coronavirus Replication Complex Formation Utilizes Components of Cellular Autophagy* (2004) (431)
- Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. (2011) (417)
- Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase (2019) (401)
- Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing (2010) (393)
- Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics (2013) (384)
- Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus (2003) (365)
- Coronaviruses (2011) (354)
- Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice (2020) (347)
- Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants (2021) (322)
- Systematic Assembly of a Full-Length Infectious cDNA of Mouse Hepatitis Virus Strain A59 (2002) (320)
- High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants (2007) (290)
- Evaluation of candidate vaccine approaches for MERS-CoV (2015) (275)
- Severe Acute Respiratory Syndrome Coronavirus Group-Specific Open Reading Frames Encode Nonessential Functions for Replication in Cell Cultures and Mice (2005) (267)
- Identification and Characterization of Severe Acute Respiratory Syndrome Coronavirus Replicase Proteins (2004) (259)
- Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice (2008) (251)
- A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease (2012) (218)
- Localization of Mouse Hepatitis Virus Nonstructural Proteins and RNA Synthesis Indicates a Role for Late Endosomes in Viral Replication (1999) (214)
- Middle East Respiratory Syndrome. (2017) (211)
- Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance (2019) (194)
- Coronavirus Replication Does Not Require the Autophagy Gene ATG5 (2007) (193)
- The nsp2 Replicase Proteins of Murine Hepatitis Virus and Severe Acute Respiratory Syndrome Coronavirus Are Dispensable for Viral Replication (2005) (178)
- The coronavirus proofreading exoribonuclease mediates extensive viral recombination (2020) (156)
- Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape (2018) (142)
- Nucleoside analogues for the treatment of coronavirus infections (2019) (142)
- Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens (2016) (137)
- SARS coronavirus replicase proteins in pathogenesis (2007) (136)
- SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness (2020) (128)
- Four Proteins Processed from the Replicase Gene Polyprotein of Mouse Hepatitis Virus Colocalize in the Cell Periphery and Adjacent to Sites of Virion Assembly (2000) (128)
- Characterization of the Expression, Intracellular Localization, and Replication Complex Association of the Putative Mouse Hepatitis Virus RNA-Dependent RNA Polymerase (2003) (124)
- Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses. (2014) (110)
- Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59 (1995) (108)
- The Putative Helicase of the Coronavirus Mouse Hepatitis Virus Is Processed from the Replicase Gene Polyprotein and Localizes in Complexes That Are Active in Viral RNA Synthesis (1999) (103)
- Coronavirus Protein Processing and RNA Synthesis Is Inhibited by the Cysteine Proteinase Inhibitor E64d (1995) (103)
- Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses (2013) (102)
- Seeking Membranes: Positive-Strand RNA Virus Replication Complexes (2008) (102)
- Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events (1992) (102)
- Coronaviruses as DNA Wannabes: A New Model for the Regulation of RNA Virus Replication Fidelity (2013) (97)
- Single-Amino-Acid Substitutions in Open Reading Frame (ORF) 1b-nsp14 and ORF 2a Proteins of the Coronavirus Mouse Hepatitis Virus Are Attenuating in Mice (2005) (96)
- Chimeric Exchange of Coronavirus nsp5 Proteases (3CLpro) Identifies Common and Divergent Regulatory Determinants of Protease Activity (2013) (95)
- Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2 (2020) (93)
- Processing of Open Reading Frame 1a Replicase Proteins nsp7 to nsp10 in Murine Hepatitis Virus Strain A59 Replication (2007) (93)
- Translation and processing of mouse hepatitis virus virion RNA in a cell-free system (1986) (91)
- Mouse Hepatitis Virus Replicase Proteins Associate with Two Distinct Populations of Intracellular Membranes (2000) (86)
- Murine Hepatitis Virus Nonstructural Protein 4 Regulates Virus-Induced Membrane Modifications and Replication Complex Function (2009) (80)
- Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus. (2010) (74)
- Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication (2005) (72)
- Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro) (2015) (71)
- Mouse Hepatitis Virus Replicase Protein Complexes Are Translocated to Sites of M Protein Accumulation in the ERGIC at Late Times of Infection (2001) (70)
- Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD (2019) (69)
- Identification of putative polymerase gene product in cells infected with murine coronavirus A59 (1987) (68)
- Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL) IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS* (2015) (68)
- A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant (2014) (66)
- Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses (2016) (64)
- Mouse Hepatitis Virus 3C-Like Protease Cleaves a 22-Kilodalton Protein from the Open Reading Frame 1a Polyprotein in Virus-Infected Cells and In Vitro (1998) (59)
- Mutations in Coronavirus Nonstructural Protein 10 Decrease Virus Replication Fidelity (2015) (59)
- Multicenter Initial Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2 (2020) (58)
- Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice (2020) (58)
- Intracellular Localization and Protein Interactions of the Gene 1 Protein p28 during Mouse Hepatitis Virus Replication (2004) (56)
- Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2 (2020) (55)
- Analysis of Murine Hepatitis Virus Strain A59 Temperature-Sensitive Mutant TS-LA6 Suggests that nsp10 Plays a Critical Role in Polyprotein Processing (2007) (53)
- Identification of polypeptides encoded in open reading frame 1b of the putative polymerase gene of the murine coronavirus mouse hepatitis virus A59 (1991) (52)
- Murine Hepatitis Virus Replicase Protein nsp10 Is a Critical Regulator of Viral RNA Synthesis (2007) (52)
- Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses (2012) (51)
- Intracellular andin Vitro-Translated 27-kDa Proteins Contain the 3C-like Proteinase Activity of the Coronavirus MHV-A59 (1996) (51)
- Cleavage between Replicase Proteins p28 and p65 of Mouse Hepatitis Virus Is Not Required for Virus Replication (2004) (50)
- Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations (2017) (50)
- An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus (2020) (50)
- Identification and Characterization of a 65-kDa Protein Processed from the Gene 1 Polyprotein of the Murine Coronavirus MHV-A59 (1995) (50)
- Survival experience of 789 children with the acquired immunodeficiency syndrome. (1993) (49)
- Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms (2022) (49)
- Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity (2016) (45)
- Severe Acute Respiratory Syndrome Coronavirus Pathogenesis, Disease and Vaccines: An Update (2004) (45)
- Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity (2017) (44)
- Mutations across Murine Hepatitis Virus nsp4 Alter Virus Fitness and Membrane Modifications (2014) (44)
- Multicenter interim guidance on use of antivirals for children with COVID-19/SARS-CoV-2 (2020) (44)
- Veillonella parvula bacteremia without an underlying source (1996) (43)
- Coronaviruses Induce Entry-Independent, Continuous Macropinocytosis (2014) (42)
- Determinants of Mouse Hepatitis Virus 3C-like Proteinase Activity (1997) (41)
- In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins (2017) (41)
- Replication of Murine Hepatitis Virus Is Regulated by Papain-Like Proteinase 1 Processing of Nonstructural Proteins 1, 2, and 3 (2006) (39)
- Temperature-Sensitive Mutants and Revertants in the Coronavirus Nonstructural Protein 5 Protease (3CLpro) Define Residues Involved in Long-Distance Communication and Regulation of Protease Activity (2012) (39)
- Stabilized coronavirus spike stem elicits a broadly protective antibody (2021) (39)
- Genetic Analysis of Murine Hepatitis Virus nsp4 in Virus Replication (2007) (36)
- Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry (2015) (31)
- Fatal fat embolism syndrome in a child with undiagnosed hemoglobin S/beta+ thalassemia: a complication of acute parvovirus B19 infection. (1996) (30)
- The NSP2 Proteins of Mouse Hepatitis Virus and Sars Coronavirus are Dispensable for Viral Replication (2006) (30)
- Murine Coronaviruses Encoding nsp2 at Different Genomic Loci Have Altered Replication, Protein Expression, and Localization (2008) (30)
- Expression and processing of nonstructural proteins of the human astroviruses. (1998) (29)
- Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit (2021) (26)
- Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Amman, Jordan, March 2010 to September 2012 (2013) (24)
- Coronavirus Replicase-Reporter Fusions Provide Quantitative Analysis of Replication and Replication Complex Formation (2014) (23)
- Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape. (2018) (21)
- ANDES: Statistical tools for the ANalyses of DEep Sequencing (2010) (20)
- Novel poxvirus infection in 2 patients from the United States. (2015) (20)
- A Novel Mutation in Murine Hepatitis Virus nsp5, the Viral 3C-Like Proteinase, Causes Temperature-Sensitive Defects in Viral Growth and Protein Processing (2008) (18)
- Effects of Mutagenesis of Murine Hepatitis Virus NSP1 and NSP14 on Replication in Culture (2006) (17)
- Coronavirus polyprotein processing. (1994) (17)
- Exchange of the Coronavirus Replicase Polyprotein Cleavage Sites Alters Protease Specificity and Processing (2010) (16)
- Sars Coronavirus Accessory ORFs Encode Luxury Functions (2006) (16)
- THE COMMON COLD : RHINOVIRUSES AND CORONAVIRUSES (1999) (15)
- Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses (2018) (15)
- Innovations in Antiviral Development and the Detection of Virus Infections (2012) (14)
- Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase. (1998) (12)
- Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults (2021) (11)
- Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus (2019) (10)
- Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized With COVID-19 (2022) (10)
- Unilateral facial paralysis occurring in an infant with enteroviral otitis media and aseptic meningitis. (2002) (9)
- Neonatal renal abscess caused by Staphylococcus aureus (1991) (9)
- The cell biology of coronavirus infection. (2001) (9)
- Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive (2012) (8)
- Inhibition of coronavirus MHV-A59 replication by proteinase inhibitors. (1995) (8)
- Standardized two-step testing of antibody activity in COVID-19 convalescent plasma (2021) (7)
- Reovirus RNA Recombination Is Sequence Directed and Generates Internally Deleted Defective Genome Segments during Passage (2020) (7)
- MHV-A59 Orf1a Replicase Protein NSP7-NSP10 Processing in Replication (2006) (6)
- A newly identified MHV-A59 ORF1a polypeptide p65 is temperature sensitive in two RNA negative mutants. (1993) (6)
- Broad-spectrum Investigational Agent GS-5734 for the Treatment of Ebola, MERS Coronavirus and Other Pathogenic Viral Infections with High Outbreak Potential (2017) (6)
- Molecular targets for the rational design of drugs to inhibit SARS coronavirus (2004) (6)
- Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir (2022) (5)
- Viral pharyngitis (1995) (5)
- Cell Biology of Nidovirus Replication Complexes (2008) (5)
- Proofreading-deficient coronaviruses adapt over long-term passage for increased fidelity and fitness without reversion of exoribonuclease-inactivating mutations (2017) (3)
- Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults (2021) (3)
- MHV-A59 gene 1 proteins are associated with two distinct membrane populations. (2001) (3)
- CORONAVIRUS RESEARCH: KEYS TO DIAGNOSIS, TREATMENT, AND PREVENTION OF SARS (2004) (3)
- Proteolytic Processing of the Coronavirus Replicase Nonstructural Protein 14 Exonuclease Is Not Required for Virus Replication but Alters RNA Synthesis and Viral Fitness (2022) (2)
- Expression, purification, and activity of recombinant MHV-A59 3CLpro. (1998) (2)
- H1N1 infection mimicking the clinical presentation of gastrointestinal GVHD in a patient following allo-SCT (2011) (2)
- Identification of a critical horseshoe-shaped region in the nsp5 (Mpro, 3CLpro) protease interdomain loop (IDL) of coronavirus mouse hepatitis virus (MHV) (2020) (2)
- Mouse hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity (2017) (2)
- Translation and processing of MHV-A59 virion RNA in reticulocyte lysates and infected cells. (1987) (2)
- Misidentification of Neisseria species in a neonate with conjunctivitis. (1988) (2)
- Coronavirus Picornain-like Cysteine Proteinase (2012) (1)
- Integrating SARS-CoV-2 Antibody Results in Children into Pandemic Response. (2022) (0)
- Acknowledgment to reviewers (2018) (0)
- Antiviral Agents for SARS (2008) (0)
- Chapter 291-Coronaviruses (2019) (0)
- Explorer Middle East Respiratory Syndrome (2017) (0)
- A complete assimilation process that leads seekers to become leaders at First Baptist Church, Gainesville, Texas (2003) (0)
- Recovery of Putative Temperature-Sensitive Mutations in Coronavirus Nonstructural Protein 5 Reveals Conserved Determinants of nsp 5 Structure (2013) (0)
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness Preview (2020) (0)
- Coronavirus Subversion of Host Cell Membranes (0)
- Contents (2012) (0)
- Positive‐strand RNA viruses—a Keystone Symposia report (2023) (0)
- Review of The PDR for Mental Health Professionals. (2003) (0)
- Edinburgh Research Explorer Middle East Respiratory Syndrome (2017) (0)
- The language of incipient opposition: the discourse of the party of democratic socialism in German politics 1989-1995 (1997) (0)
- Identification ofPolypeptides EncodedinOpenReading Framelbof thePutative Polymerase GeneoftheMurineCoronavirus Mouse Hepatitis VirusA59 (1991) (0)
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness (2020) (0)
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