Mark Shlomchik

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Mark Shlomchik is affiliated with the following schools: Yale University, University of Pittsburgh, University of Pennsylvania, Harvard University

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Mark Shlomchik

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Biology

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Doctorate Medicine Harvard University

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According to Wikipedia, Mark Jay Shlomchik is an American immunologist currently UPMC Endowed Professor and chair at University of Pittsburgh.

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Mark Shlomchik's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors (2002) (2013)
Prevention of graft versus host disease by inactivation of host antigen-presenting cells. (1999) (1238)
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. (2006) (1022)
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement (2005) (826)
A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus (1999) (736)
The role of clonal selection and somatic mutation in autoimmunity (1987) (733)
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation (1990) (671)
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells (2010) (637)
From T to B and back again: positive feedback in systemic autoimmune disease (2001) (584)
Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. (2005) (576)
Activation of autoreactive B cells by CpG dsDNA. (2003) (575)
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus (2005) (549)
Evolution of Autoantibody Responses via Somatic Hypermutation Outside of Germinal Centers (2002) (541)
Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. (1987) (487)
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. (2007) (417)
Memory CD4+ T cells do not induce graft-versus-host disease. (2003) (416)
The role of B cells in lpr/lpr-induced autoimmunity (1994) (397)
The Immune System in Health and Disease (2001) (392)
Germinal center selection and the development of memory B and plasma cells (2012) (387)
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells. (2014) (362)
A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice. (1998) (327)
TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus (2010) (326)
Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. (2016) (323)
MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies (2013) (321)
Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. (2007) (315)
CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype (2014) (307)
Sites and stages of autoreactive B cell activation and regulation. (2008) (303)
Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/lpr Mice1 (2009) (292)
The central and multiple roles of B cells in lupus pathogenesis (1999) (291)
New markers for murine memory B cells that define mutated and unmutated subsets (2007) (260)
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps (2019) (243)
B Cell Receptor Signal Transduction in the GC Is Short-Circuited by High Phosphatase Activity (2012) (239)
Depletion of B Cells in Murine Lupus: Efficacy and Resistance1 (2007) (236)
T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. (2008) (227)
Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. (2004) (224)
Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. (2004) (223)
Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets (2010) (217)
Attenuated liver fibrosis in the absence of B cells. (2005) (216)
NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus (2012) (212)
Target Antigens Determine Graft-versus-Host Disease Phenotype (2004) (211)
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. (2012) (210)
Antigen-Specific B Cells Are Required as APCs and Autoantibody-Producing Cells for Induction of Severe Autoimmune Arthritis1 (2005) (207)
Investigation of the role of B-cells in type 1 diabetes in the NOD mouse. (2004) (206)
Autocrine/paracrine TGFβ1 is required for the development of epidermal Langerhans cells (2007) (202)
Plasticity and Heterogeneity in the Generation of Memory B Cells and Long-Lived Plasma Cells: The Influence of Germinal Center Interactions and Dynamics (2010) (202)
Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. (2008) (200)
Memory B Cells of Mice and Humans. (2017) (199)
Germinal Center Initiation, Variable Gene Region Hypermutation, and Mutant B Cell Selection without Detectable Immune Complexes on Follicular Dendritic Cells (2000) (192)
Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. (2010) (189)
Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. (1998) (186)
B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c‐Myc Transcription Factor in Germinal Center B Cells (2018) (183)
Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced (2002) (183)
Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis (2000) (183)
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact (2008) (182)
B cells are required for lupus nephritis in the polygenic, Fas-intact MRL model of systemic autoimmunity. (1999) (181)
Maintenance of the plasma cell pool is independent of memory B cells (2008) (173)
A B-cell receptor-specific selection step governs immature to mature B cell differentiation. (2000) (172)
The complement system and innate immunity (2001) (167)
Requirement of B Cells for Generating CD4+ T Cell Memory1 (2009) (167)
Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors. (2007) (166)
Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation. (2015) (163)
Tissue‐Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells (2017) (159)
A rheumatoid factor transgenic mouse model of autoantibody regulation. (1993) (153)
A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease (1996) (147)
A Shannon entropy analysis of immunoglobulin and T cell receptor. (1997) (146)
Langerhans Cells Suppress Contact Hypersensitivity Responses Via Cognate CD4 Interaction and Langerhans Cell-Derived IL-101 (2009) (142)
Activating systemic autoimmunity: B's, T's, and tolls. (2009) (142)
Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. (2013) (142)
Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity. (2020) (141)
Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cells (1986) (128)
Mechanisms of Central Nervous System Viral Persistence: the Critical Role of Antibody and B Cells1 (2002) (128)
Reassessing the function of immune-complex retention by follicular dendritic cells (2003) (127)
Suppression of systemic autoimmunity by the innate immune adaptor STING (2015) (124)
Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma (2012) (122)
B-Cell Depletion In Vitro and In Vivo with an Afucosylated Anti-CD19 Antibody (2010) (121)
B Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation1 (2006) (120)
Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). II. Comparison of hybridomas derived by lipopolysaccharide stimulation and secondary protein immunization (1987) (113)
Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis (2020) (113)
Murine B Cell Response to TLR7 Ligands Depends on an IFN-β Feedback Loop1 (2009) (112)
Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge (2009) (108)
Short-Lived Plasmablasts Dominate the Early Spontaneous Rheumatoid Factor Response: Differentiation Pathways, Hypermutating Cell Types, and Affinity Maturation Outside the Germinal Center1 (2005) (106)
Principles of innate and adaptive immunity (2001) (101)
Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells1 (2009) (98)
The major histocompatibility complex and its functions (2001) (98)
Organogenic role of B lymphocytes in mucosal immunity. (1999) (96)
CD80 Expression on B Cells Regulates Murine T Follicular Helper Development, Germinal Center B Cell Survival, and Plasma Cell Generation (2012) (96)
B Cell-Derived IL-10 Does Not Regulate Spontaneous Systemic Autoimmunity in MRL.Faslpr Mice (2012) (95)
Faculty Opinions recommendation of Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. (2005) (95)
Cutting Edge: Transplant Tolerance Induced by Anti-CD45RB Requires B Lymphocytes1 (2007) (93)
Systematic Comparison of Gene Expression between Murine Memory and Naive B Cells Demonstrates That Memory B Cells Have Unique Signaling Capabilities1 (2008) (92)
Improved methods for detecting selection by mutation analysis of Ig V region sequences. (2008) (92)
Autoreactive B Cells Discriminate CpG-Rich and CpG-Poor DNA and This Response Is Modulated by IFN-α1 (2008) (91)
Detecting selection in immunoglobulin sequences (2011) (91)
Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. (2008) (90)
V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice. (1993) (89)
Autoantigen-Specific B Cell Activation in FAS-Deficient Rheumatoid Factor Immunoglobulin Transgenic Mice (1999) (85)
An atlas of B-cell clonal distribution in the human body (2017) (85)
Estimating Hypermutation Rates from Clonal Tree Data 1 (2003) (84)
In vivo imaging studies shed light on germinal-centre development (2007) (84)
Immune Complexes Present in the Sera of Autoimmune Mice Activate Rheumatoid Factor B Cells1 (2000) (81)
Histone modifications associated with somatic hypermutation. (2005) (81)
Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted (2018) (80)
Anti‐chromatin antibodies drive in vivo antigen‐specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites (2007) (77)
Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells (2016) (77)
The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. (1994) (76)
B Cell–Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus (2015) (74)
PIRs mediate innate myeloid cell memory to nonself MHC molecules (2020) (73)
Rituximab Therapy Reduces Organ-Specific T Cell Responses and Ameliorates Experimental Autoimmune Encephalomyelitis (2011) (73)
Linking signaling and selection in the germinal center (2019) (73)
Cutting Edge: B Cells Are Essential for Protective Immunity against Salmonella Independent of Antibody Secretion (2012) (73)
The Humoral Immune Response (2001) (72)
Exacerbated Autoimmunity in the Absence of TLR9 in MRL.Faslpr Mice Depends on Ifnar1 (2013) (72)
Context-specific BAFF-R signaling by the NF-κB and PI3K pathways. (2013) (70)
Structural patterns in anti-DNA antibodies from MRL/lpr mice. (1989) (68)
T Cell-Mediated Immunity (2001) (67)
The Roles of B Cells in MRL/lpr Murine Lupus (1997) (67)
Deficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level1 (2001) (66)
The structure of a typical antibody molecule (2001) (66)
Lupus and proliferative nephritis are PAD4 independent in murine models. (2017) (65)
Clone: a Monte-Carlo computer simulation of B cell clonal expansion, somatic mutation, and antigen-driven selection. (1998) (64)
Langerhans cells are not required for efficient skin graft rejection. (2008) (63)
High affinity rheumatoid factor transgenic B cells are eliminated in normal mice. (1997) (62)
IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity (2013) (60)
Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo (2011) (60)
Single round of antigen receptor signaling programs naive B cells to receive T cell help. (2010) (60)
TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation (2013) (59)
Neuroinvasion by a Creutzfeldt–Jakob disease agent in the absence of B cells and follicular dendritic cells (2001) (58)
B Cell Tolerance Checkpoints That Restrict Pathways of Antigen-Driven Differentiation1 (2006) (57)
Intrinsic properties of human and murine memory B cells (2006) (57)
Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. (2009) (56)
Antibody effector functions mediated by Fcγ-receptors are compromised during persistent viral infection. (2015) (55)
B Cell–Intrinsic mTORC1 Promotes Germinal Center–Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity (2018) (54)
Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease. (2001) (54)
Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses. (2020) (53)
Antibody Is Required for Clearance of Infectious Murine Hepatitis Virus A59 from the Central Nervous System, But Not the Liver1 (2001) (53)
Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus. (2015) (52)
Dual infection with Pneumocystis carinii and Pasteurella pneumotropica in B cell-deficient mice: diagnosis and therapy. (2000) (51)
A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data (2016) (51)
RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes (2010) (51)
Antigen Recognition by B-cell and T-cell Receptors (2001) (50)
Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection. (2015) (50)
Langerhans cells are not required for graft-versus-host disease. (2011) (49)
The Influence of Somatic Mutation on Clonal Expansion (1989) (48)
A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation (2010) (48)
CD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence (2014) (47)
Autocrine/paracrine TGFb1 is required for the development of epidermal Langerhans cells (2007) (47)
The distribution and functions of immunoglobulin isotypes (2001) (47)
Differential Cytokine Production and Bystander Activation of Autoreactive B Cells in Response to CpG-A and CpG-B Oligonucleotides1 (2009) (47)
Cutting Edge: Memory B Cell Survival and Function in the Absence of Secreted Antibody and Immune Complexes on Follicular Dendritic Cells1 (2006) (46)
Comprehensive analyses of B cell compartments across the human body reveal novel subsets and a gut resident memory phenotype. (2020) (46)
The role of antibodies and B cells in the pathogenesis of lupus nephritis (2003) (46)
Basic Concepts in Immunology (2001) (45)
Heavy-chain class switch does not terminate somatic mutation (1990) (45)
A solution to the rheumatoid factor paradox: pathologic rheumatoid factors can be tolerized by competition with natural rheumatoid factors. (1997) (45)
The Role of Innate Immunity in Autoimmunity (2004) (44)
B cell-intrinsic TLR9 expression is protective in murine lupus. (2020) (43)
The B Cell Receptor Itself Can Activate Complement to Provide the Complement Receptor 1/2 Ligand Required to Enhance B Cell Immune Responses In Vivo (2003) (43)
A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells. (2011) (42)
Visualizing the Onset and Evolution of an Autoantibody Response in Systemic Autoimmunity1 (2005) (42)
Expression of Diabetes-Associated Genes by Dendritic Cells and CD4 T Cells Drives the Loss of Tolerance in Nonobese Diabetic Mice1 (2009) (41)
ZBTB32 Restricts the Duration of Memory B Cell Recall Responses (2016) (41)
The Development and Survival of Lymphocytes (2001) (40)
Autoimmunity and Transplantation (2001) (38)
The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells (2019) (38)
Cutting Edge: B Cells Promote CD8+ T Cell Activation in MRL-Faslpr Mice Independently of MHC Class I Antigen Presentation1 (2000) (38)
Structure, map position, and evolution of two newly diverged mouse Ig VH gene families. (1991) (37)
Antigen presentation and transfer between B cells and macrophages (2007) (37)
Multiple Transcription Factor Binding Sites Predict AID Targeting in Non-Ig Genes (2013) (36)
An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-lpr/lpr mouse exhibits limited intraclonal affinity maturation. (1994) (36)
Differences in potential for amino acid change after mutation reveals distinct strategies for κ and λ light-chain variation (2006) (36)
Kidney Proximal Tubular TLR9 Exacerbates Ischemic Acute Kidney Injury (2018) (36)
B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex. (2018) (35)
Emerging concepts regarding B cells and autoantibodies in murine lupus nephritis. B cells have multiple roles; all autoantibodies are not equal. (1996) (34)
Memory B cell survival and function in the absence of secreted antibody and immune complexes on follicular dendritic cells. (2006) (33)
An Acquired Defect in IgG-Dependent Phagocytosis Explains the Impairment in Antibody-Mediated Cellular Depletion in Lupus (2011) (32)
Germinal centers (2012) (31)
Integrating B Cell Lineage Information into Statistical Tests for Detecting Selection in Ig Sequences (2014) (31)
Rheumatoid Factor B Cell Memory Leads to Rapid, Switched Antibody-Forming Cell Responses (2013) (31)
Do Memory B Cells Form Secondary Germinal Centers? Yes and No. (2018) (30)
B-cell activation by armed helper T cells (2001) (30)
Antigen Presentation to T Lymphocytes (2001) (29)
Allergy and Hypersensitivity (2001) (29)
Targeting Antigens through Blood Dendritic Cell Antigen 2 on Plasmacytoid Dendritic Cells Promotes Immunologic Tolerance (2014) (27)
Maternal Ig mediates neonatal tolerance in rheumatoid factor transgenic mice but tolerance breaks down in adult mice. (1998) (27)
Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease (2015) (27)
Langerhans Cell Deficiency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice (2009) (26)
Recipient B cells are not required for graft-versus-host disease induction. (2010) (26)
Liver Is a Generative Site for the B Cell Response to Ehrlichia muris. (2019) (26)
The Generation of Lymphocyte Antigen Receptors (2001) (26)
Activation of Rheumatoid Factor (RF) B Cells and Somatic Hypermutation Outside of Germinal Centers in Autoimmune‐Prone MRL/lpr Mice (2003) (25)
Requirement for Transcription Factor Ets1 in B Cell Tolerance to Self-Antigens (2015) (25)
IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression. (2019) (25)
Activation of Rheumatoid Factor–Specific B Cells Is Antigen Dependent and Occurs Preferentially Outside of Germinal Centers in the Lupus-Prone NZM2410 Mouse Model (2014) (23)
Surface phenotypes of naive and memory B cells in mouse and human tissues (2021) (23)
Infectious agents and how they cause disease (2001) (23)
The front line of host defense (2001) (22)
High-dose chemotherapy followed by reinfusion of selected CD34+ peripheral blood cells in patients with poor-prognosis breast cancer: a randomized multicentre study. (1998) (22)
Antibody‐independent B cell‐intrinsic and ‐extrinsic roles for CD21/35 (2006) (22)
Manipulation of the Immune Response (2001) (22)
Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice (2017) (22)
An Introduction to Immunobiology and Innate Immunity (2001) (22)
The interaction of the antibody molecule with specific antigen (2001) (21)
Signaling Through Immune System Receptors (2001) (21)
B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus (2016) (21)
PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease (2018) (20)
Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand. (2016) (20)
Differences in potential for amino acid change after mutation reveals distinct strategies for kappa and lambda light-chain variation. (2006) (20)
Making Digoxin Therapeutic Drug Monitoring More Effective (1991) (20)
A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice (2021) (19)
B Cell–Extrinsic Myd88 and Fcer1g Negatively Regulate Autoreactive and Normal B Cell Immune Responses (2017) (19)
The generation of diversity in immunoglobulins (2001) (19)
Autoimmune responses are directed against self antigens (2001) (18)
Recipient CD 4 T cells that survive irradiation regulate chronic graft-versus-host disease (2004) (18)
A test for clonal relatedness in a set of lymphocytes (1990) (17)
Macrophage activation by armed CD4 TH1 cells (2001) (17)
Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4+ effector memory T cells (2011) (16)
Failures of Host Defense Mechanisms (2001) (16)
Rheumatoid factors in health and disease: structure, function, induction and regulation. (2002) (15)
Adaptive Immunity to Infection (2001) (15)
Estimating Hypermutation Rates from Clonal Tree Data (2003) (15)
Isolation and flow cytometric analysis of T‐cell‐depleted CD34+ PBPCs (2000) (14)
The Type II Anti‐CD20 Antibody Obinutuzumab (GA101) Is More Effective Than Rituximab at Depleting B Cells and Treating Disease in a Murine Lupus Model (2020) (14)
Generation of lymphocytes in bone marrow and thymus (2001) (14)
B cells are capable of independently eliciting rapid reactivation of encephalitogenic CD4 T cells in a murine model of multiple sclerosis (2018) (14)
Effector mechanisms in allergic reactions (2001) (13)
The components of the immune system (2001) (13)
Responses to alloantigens and transplant rejection (2001) (13)
Memory T cells in GVHD and GVL. (2008) (13)
Spontaneous Loss of Tolerance of Autoreactive B Cells in Act1-Deficient Rheumatoid Factor Transgenic Mice (2013) (13)
Induced innate responses to infection (2001) (12)
Using the immune response to attack tumors (2001) (12)
Pathogens have evolved various means of evading or subverting normal host defenses (2001) (12)
Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation. (2017) (12)
B-Cell Depletion In Vitro and In Vivo with an Afucosylated Anti-CD 19 Antibody (2010) (12)
Structural variation in immunoglobulin constant regions (2001) (12)
The Adaptive Immune Response (2001) (11)
Regulation of autoreactive anti-IgG (Rheumatoid Factor) B cells in normal and autoimmune mice (1999) (10)
Evolution of the innate immune system (2001) (10)
The mucosal immune system (2001) (10)
B cell primary immune responses (2019) (9)
T-Cell Receptor Gene Rearrangement (2020) (9)
The destruction of antibody-coated pathogens via Fc receptors (2001) (8)
The course of the adaptive response to infection (2001) (8)
The Recognition of Antigen (2001) (8)
General properties of armed effector T cells (2001) (7)
Manipulating the immune response to fight infection (2001) (7)
Adoptive Transfer of Memory B Cells. (2015) (7)
Self-tolerance and its loss (2001) (6)
Receptors of the innate immune system (2001) (6)
Antigen recognition by T cells (2001) (6)
The production of armed effector T cells (2001) (6)
The rearrangement of antigen-receptor gene segments controls lymphocyte development (2001) (5)
The Influence of Migration, Alloreactive Repertoire and Memory Subset on the Differential Ability of Naive and Memory T Cells To Induce GVHD. (2005) (5)
The recognition and effector mechanisms of adaptive immunity (2001) (5)
KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. (2019) (5)
B Cells and Dendritic Cells from Vκ8 Light Chain Transgenic Mice Activate MRL-lpr/gld CD4+ T Cells1 (2006) (5)
Survival and maturation of lymphocytes in peripheral lymphoid tissues (2001) (4)
CD4 + Effector Memory and Naive T Cells Mediate Graft-Versus-Leukemia Via Direct Recognition of MHCII on Leukemic Cells. (2005) (4)
The production of IgE (2001) (4)
T cell-mediated cytotoxicity (2001) (4)
Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus (2022) (4)
Recipient gammadelta T cells in graft-versus-host disease. (2006) (4)
Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model (2019) (4)
BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis (2019) (3)
Autoimmunity: The genes and phenotypes of autoimmunity. (2004) (3)
Is the hypothesis alive that IgM anti-IgG1 rheumatoid factor specificity is determined by framework regions? (1990) (3)
Identifying Tissue-Resident Memory T Cells in Graft-Versus-Host Disease (2016) (3)
CD8+ Central Memory T Cells Mediate Graft-Versus-Host Disease Although Retain Graft-Versus-Leukemia Effect. (2005) (3)
Antigen receptor structure and signaling pathways (2001) (3)
Extrinsic regulation of unwanted immune responses (2001) (3)
Appendix I. Immunologists' Toolbox (2001) (3)
The importance of immunological memory in fixing adaptive immunity in the genome (2001) (3)
Heterogeneity and clonality of kidney-infiltrating T cells in murine lupus nephritis (2022) (3)
Interaction with self antigens selects some lymphocytes for survival but eliminates others (2001) (2)
The Development of Mature Lymphocyte Receptor Repertoires (2001) (2)
Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Fas Mice: An Example of Disease Regulation at the Organ Level (2001) (2)
The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients (2021) (2)
Roles of Bone Morphogenetic Protein Receptor 1A in Germinal Centers and Long-Lived Humoral Immunity (2021) (2)
Resident Macrophages are Locally Programmed for Silent Clearance of Apoptotic Cells (2017) (2)
Myelin-specific B cell receptor transgenic mice reveal critical role for B cell accessory function independent of antibodies in pathogenesis of CNS autoimmune disease (148.2) (2011) (2)
TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219) (2014) (2)
Appendix III. Cytokines and Their Receptors (2001) (2)
The role of B cells in mouse hepatitis virus infection and pathology. (2001) (2)
Autocrine/paracrine TGF (cid:2) 1 is required for the development of epidermal Langerhans cells (2007) (2)
Future directions of research in immunobiology (2001) (2)
CHAPTER 22 – Selection During Antigen-Driven B Cell Immune Responses: The Basis for High Affinity Antibody (2004) (2)
Rituximab treatment reduces organ-specific T cell effector responses and ameliorates Experimental Autoimmune Encephalomyelitis (107.3) (2011) (1)
II-13 Suppression of systemic autoimmunity by the innate immune adaptor sting (2016) (1)
Animal Models of Autoimmunity (2016) (1)
Appendix IV. Chemokines and Their Receptors (2001) (1)
Spatial map of human B cell compartmentalization (2018) (1)
Independently of MHC Class I Antigen Mice lpr Activation in MRL-Fas T Cell + Cutting Edge : B Cells Promote CD 8 (2000) (1)
Correction to: The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients (2021) (1)
Hypermutation Outside of Germinal Centers Evolution of Autoantibody Responses via Somatic (2008) (1)
Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice. (2023) (1)
IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells (2023) (1)
This information is current as Predict AID Targeting in Non-Ig Genes Multiple Transcription Factor Binding Sites (2013) (1)
Spontaneous opticospinal encephalomyelitis and meningeal follicles develop in the absence of antibodies (2013) (1)
Summary to Chapter 14 (2001) (1)
A New TCR Transgenic Model of GVHD Reveals That, Independent of Repertoire, Effector Memory T Cells Are Severely Limited, and Central Memory T Cells Somewhat Limited, in Their Ability to Cause GVHD. (2009) (1)
General principles of transmembrane signaling (2001) (1)
Glucose Requirement of Antigen-Specific Autoreactive B Cells and CD4+ T Cells. (2023) (1)
The generation of T-cell receptor ligands (2001) (1)
disease induction by naive and memory phenotype CD4 T cells Effects of donor T-cell trafficking and priming site on graft-versus-host (2013) (1)
Summary to Chapter 8 (2001) (1)
activation I (rituximab-like) reagents in B-cell depletion regardless of complement Type II (tositumomab) anti-CD20 monoclonal antibody out performs type (2013) (1)
Spontaneous Memory CD4+ T Cells Preserve Graft-Versus-Leukemia without Causing Graft-Versus-Host Disease. (2004) (1)
B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells. (2006) (1)
Murine Memory B Cell Subsets Cutting Edge: Hierarchy of Maturity of (1)
Blimp1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4 (2022) (0)
Summary to Chapter 3 (2001) (0)
B cell extrinsic MyD88 and FcRγ control contraction of the extrafollicular B cell response (61.12) (2011) (0)
Toll-Like Receptor and Autoimmunity. (2009) (0)
Infectious Murine Hepatitis Virus A59 from Antibody Is Required for Clearance of (0)
Do autoreactive memory B cells form as a consequence of extrafollicular activation? (130.18) (2007) (0)
Figure 11.14, Defects in complement components are associated with susceptibility to certain infections and accumulation of immune complexes (2001) (0)
HOW AUTOREACTIVE B CELLS ARE ACTIVATED (2010) (0)
The Irf4 Gene, a Susceptibility Locus for Chronic Lymphocytic Leukemia (CLL), Controls Establishment of Follicular and Marginal Zone B Cell Compartments in Mice (2011) (0)
SequencesStatistical Tests for Detecting Selection in Ig Integrating B Cell Lineage Information into (2013) (0)
Prizewinning Insights Into the Future of Lupus Research (2013) (0)
Compared to Low-Affinity Cells Rates, but Similar Rates of Division, the Germinal Center Have Lower Death Taking Advantage: High-Affinity B Cells in (2009) (0)
Persistence of Virus-Specific Antibody after Depletion of Memory B Cells (2022) (0)
Pathways of Antigen-Driven Differentiation B Cell Tolerance Checkpoints That Restrict (2006) (0)
Summary to Chapter 7 (2001) (0)
Figure 7.9, The thymus is critical for the maturation of bone marrow-derived cells into T cells (2001) (0)
Figure 3.1, Structure of an antibody molecule (2001) (0)
Summary to Chapter 11 (2001) (0)
Ectopic B cell response to Ehrlichia muris in the liver (2017) (0)
The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells (2019) (0)
Independent of Antibody Secretion Salmonella Protective Immunity against Cutting Edge: B Cells Are Essential for (2012) (0)
Become Plasmacytes and Enter Germinal Antigen Drives Very Low Affinity B Cells to and Garnett (1998) (0)
Figure 1.12, Bacterial infection triggers an inflammatory response (2001) (0)
High Throughput Cloning of T Cell Receptors (TCRs) from Single Cells Reveals That TCRs Recognizing the Minor Histocompatibility Antigen HA-1 Have a Range of Affinities Despite Canonical Beta Chain Usage (2022) (0)
Mice Depends on lpr Fas TLR9 in MRL. Exacerbated Autoimmunity in the Absence of (0)
Recipient Langerhans Cells Are Neither Required Nor Sufficient for GVHD Induction in MHC-Matched Allogeneic BMT, but a Langerin+ Cell Is a Pivotal Regulator of Langerhans Cell Turnover Post Transplantation (2008) (0)
1303 Bacterial DNA induces regulatory B cells and attenuates lupus through a B cell-extrinsic, TLR9-dependent mechanism (2022) (0)
Induction of Severe Autoimmune Arthritis APCs and Autoantibody-Producing Cells for Antigen-Specific B Cells Are Required as (2017) (0)
T and B cell memory (SY3-4) Chairpersons: Toshitada Takemori, Federica Sallusto (2010) (0)
Abstract 2831: High-throughput T cell receptor cloning allows optimization of anti-miHA T cell therapies (2022) (0)
Efficacy and Resistance Depletion of B Cells in Murine Lupus: (2007) (0)
Coordinated Reactivation of Distributed Memory Traces in Primate Neocortex (2002) (0)
PARENCHYMAL INFg RESPONSE REGULATES MURINE LUPUS NEPHRITIS (2021) (0)
2.15 The Irf4 Gene, a Susceptibility Locus for Chronic Lymphocytic Leukemia, Controls Establishment of Follicular and Marginal Zone B-Cell Compartments in Mice (2011) (0)
Abstract 5189: High throughput single-cell based cloning reveals functional diversity of T cell receptors targeting minor histocompatibility antigen (2022) (0)
Appendix V. Immunological Constants (2001) (0)
Summary to Chapter 9 (2001) (0)
Figure 13.19, Autoreactive helper T cells of one specificity can drive the production of autoantibodies with several different specificities, in a phenomenon known as antigen spreading (2001) (0)
Predict AID Targeting in Non-Ig Genes Multiple Transcription Factor Binding Sites (2013) (0)
LupusAntibody-Mediated Cellular Depletion in Phagocytosis Explains the Impairment in An Acquired Defect in IgG-Dependent (2011) (0)
Figure 3.26, Peptides that bind MHC class II molecules are variable in length and their anchor residues lie at various distances from the ends of the peptide (2001) (0)
Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 Vκ8 B Cells (2019) (0)
Summary to Chapter 2 (2001) (0)
207 ABC and extrafollicular responses: mechanistic insights from murine models of lupus and infection (2022) (0)
B cell memory (WS-081) Chairpersons: Masaki Hikida, David Tarlinton (2010) (0)
Summary to Chapter 5 (2001) (0)
Loss of Tolerance in Nonobese Diabetic Mice Dendritic Cells and CD4 T Cells Drives the Expression of Diabetes-Associated Genes by (2009) (0)
Toll-like receptor (TLR-7/9), MYOD88, TIR8, dependent and independent autoantigens (2010) (0)
A germinal center B cell-specific long non-coding RNA regulates the germinal center response (2020) (0)
IRF4 Shapes the Tumor Microenvironment of Follicular Lymphoma (2022) (0)
Summary to Chapter 12 (2001) (0)
IL-10 Interaction and Langerhans Cell-Derived Hypersensitivity Responses Via Cognate CD 4 Langerhans Cells Suppress Contact (2009) (0)
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps (2019) (0)
naive and memory phenotype CD4 T cells Effects of donor T cell trafficking and priming site on GVHD induction by (2008) (0)
Figure 12.12, Eosinophils secrete a range of highly toxic granule proteins and other inflammatory mediators (2001) (0)
Antigen processing and presentation (PP-026) (2010) (0)
Toll-like receptors, session 1 (WS-001a) Chairpersons: Kensuke Miyake, Hermann Wagner (2010) (0)
Clonal selection of cross-reactive memory B cells dominates recall responses against heterologous flaviviruses without a requirement for secondary affinity maturation (2019) (0)
the Lupus-Prone NZM2410 Mouse Model Preferentially Outside of Germinal Centers in Cells Is Antigen Dependent and Occurs Specific B - Activation of Rheumatoid Factor (2014) (0)
Figure 3.4, Antibody arms are joined by a flexible hinge (2001) (0)
Preface to the Fifth Edition (2001) (0)
The B cell response to Salmonella enteric ser. Typhimurium: promiscuous B cell recruitment for early Ab followed by extrafollicular affinity maturation (MPF6P.743) (2014) (0)
and Disease in a Murine Model of Lupus MyD88-Dependent Autoantibody Production TLR9 Regulates TLR7- and (2010) (0)
This information is current as Ifnar 1 Mice Depends on lprFas TLR 9 in MRL . Exacerbated Autoimmunity in the Absence of and (2013) (0)
Rubicon promotes clinical and immunological manifestations of SLE in murine models but is not required for LC3-associated phagocytosis (LAP). (2022) (0)
High Phosphatase Activity B Cell Receptor Signal Transduction in the GC Is Short-Circuited by (2014) (0)
Correspondence (1875) (0)
Langerhans Cell Deﬁciency Impairs Ixodes scapularis Suppression of Th1 Responses in Mice (cid:1) (2009) (0)
Summary to Chapter 6 (2001) (0)
graft-versus-host disease Recipient CD4+ T cells that survive irradiation regulate chronic (2013) (0)
Role of lipid inositol phosphatase SHIP-1 in Germinal Center B cell selection and function (2017) (0)
Rubicon promotes rather than restricts murine lupus and is not required for LC3-associated phagocytosis (2022) (0)
Figure 1.10, Organization of typical gut-associated lymphoid tissue (2001) (0)
Figure 4.5, Conserved heptamer and nonamer sequences flank the gene segments encoding the V regions of heavy (H) and light (λ and κ) chains (2001) (0)
AKT targets CSK to regulate proximal BCR signaling in germinal center B cells (2018) (0)
Anti-CD20 Therapy in NOD Model of Type 1 Diabetes (131.26) (2007) (0)
Figure 14.25, Attenuation can be achieved more rapidly and reliably with recombinant DNA techniques (2001) (0)
Summary to Chapter 1 (2001) (0)
Evolution of the adaptive immune response (2001) (0)
A Phase 1/1b Multicenter Ascending Dose Study to Evaluate the Safety of HA-1 Minor Histocompatibility Antigen-Reactive TCR-Modified T Cells (BSB-1001) in Patients Undergoing HLA-Matched Allogenic Hematopoietic Stem Cell Transplant (alloSCT) for MRD+ AML or ALL or High/Very High Risk MDS (2022) (0)
Toll-Like Receptors in Development of Systemic Autoimmune Disease: In Vitro Artifact or In Vivo Paradigm? (2008) (0)
Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis (2020) (0)
Recipient B Cells Are Not Required For GVHD Induction (2011) (0)
PD-L1 and PD-L2 Protect The Heart In a T-Cell Receptor Transgenic Model Of Graft-Versus Host Disease (2013) (0)
ResponsesRapid, Switched Antibody-Forming Cell Rheumatoid Factor B Cell Memory Leads to (2013) (0)
This information is current as Germinal Center Interactions and Dynamics Long-Lived Plasma Cells : The Influence of Generation of Memory B Cells and Plasticity and Heterogeneity in the (2010) (0)
Figure 7.31, The peptides bound to MHC class II molecules can affect the T-cell receptor repertoire (2001) (0)
Graft-versus-Host Disease Phenotype Target Antigens Determine (2004) (0)
The role of B cells in neuropsychiatric disease in murine systemic lupus erythematosis (P4000) (2013) (0)
Identifying the Clonal Origins of Gvhd-Causing T Cells (2016) (0)
Figure 13.32, Tolerance to allogeneic skin can be established in bone marrow chimeric mice (2001) (0)
the Germinal Center Cell Types, and Affinity Maturation Outside Differentiation Pathways, Hypermutating Spontaneous Rheumatoid Factor Response: Short-Lived Plasmablasts Dominate the Early (2005) (0)
Toll-like receptor dependent autoantigens in animal models and humans in use to improve collagen induced arthritis (2010) (0)
402 Genetic dissection of TLR9 reveals complex regulatory and cryptic pro-inflammatory roles (2021) (0)
JKTBP (hnRNPDL) is a novel toll7/9 dependent target in humans and animal models of inflammatory rheumatic diseases (2010) (0)
Supporting Online Material for Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma (2012) (0)
Phenotypic and Clonal Analysis of Recipient B cells and Plasma Cells Entering Graft Mucosa Reveals an Association with Rejection and Evolution towards a Resident Memory Phenotype after Human Intestinal Transplantation (2018) (0)
Icons Used Throughout the Book (2001) (0)
A model of somatic hypermutation targeting in mice based on high-throughput immunoglobulin sequencing data (TECH2P.910) (2015) (0)
Figure 3.12, Structure of the T-cell receptor (2001) (0)
Oligonucleotidesin Response to CpG-A and CpG-B Bystander Activation of Autoreactive B Cells Differential Cytokine Production and (2009) (0)
A novel method for the detection and descrimination of specific HLA class I and class II alloantibodies in the screening of potential transplant recipients using expanded and cryopreserved peripheral blood T cells (1991) (0)
A Pipeline for Optimizing miHA Specific TCR Therapy for Leukemia (2022) (0)
disease ongoing acute graft-versus-host disease: a model system for the reversal of Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in (2013) (0)
1114 Parenchymal INFγ Response Regulates Murine Lupus Nephritis in a PD-L1 Independent Fashion (2022) (0)
02.41 New autoantigen (jktbp) part of stress granules closes the sensitivity gap in rheumatoid arthritis (2017) (0)
Other signaling pathways that contribute to lymphocyte behavior (2001) (0)
Spontaneous Systemic Autoimmunity in B Cell-Derived IL-10 Does Not Regulate (2011) (0)
Figure 14.17, Monoclonal antibodies that recognize tumor-specific antigens might be used in a variety of ways to help eliminate tumors (2001) (0)
505 Parenchymal INFγ response regulates murine lupus nephritis (2021) (0)
B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus (2016) (0)
Rheumatoid Factor Transgenic Mice -Deficient Act1 Autoreactive B Cells in Spontaneous Loss of Tolerance of (2013) (0)
Summary to Chapter 10 (2001) (0)
B cell extrinsic MyD88 and FcR{gamma} control contraction of the extrafollicular B cell response (2011) (0)
Immunologic Tolerance Cell Antigen 2 on Plasmacytoid Dendritic Targeting Antigens through Blood Dendritic (2014) (0)
Systemic Autoimmunity the Polygenic , Fas-Intact MRL Model of B Cells Are Required for Lupus Nephritis in Shlomchik (1999) (0)
Summary to Chapter 13 (2001) (0)
Summary of the Afterword (2001) (0)
Inherited immunodeficiency diseases (2001) (0)
A naturally-occurring mutation in IL-17F reveals a protective role for the IL-17AF heterodimer in oropharyngeal candidiasis (OPC) (2020) (0)
Figure 2.12, The proteins of the classical pathway of complement activation (2001) (0)
Generation and characterization of immune-complex specific T cells (BA8P.121) (2014) (0)
Rheumatoid factor autoimmunity in the NZM2410 model combines antigen-specific and polyclonal activation (49.16) (2009) (0)
Summary to Chapter 4 (2001) (0)
Germinal Centers and Long-Lived Humoral Immunity Roles of Bone Morphogenetic Protein Receptor 1A in (2021) (0)
AI-11 Isolating and characterising autoreactive T cells in lupus (2016) (0)
Figure 8.27, There are three classes of effector T cell, specialized to deal with three classes of pathogen (2001) (0)
Chain Transgenic Mice Activate MRL-8 Light κ B Cells and Dendritic Cells from V (2006) (0)
B Cell Tolerance to Self-Antigens in Ets 1 Requirement for Transcription Factor (2015) (0)
Low-Affinity Cells Similar Rates of Division , Compared to Germinal Center Have Lower Death Rates , but Taking Advantage : High-Affinity B Cells in the Data (2009) (0)
The CN-index of hnRNP-DL Predicts an Individual “Window of Treatment Success” in RA Patients (2021) (0)
Figure 10.31, The components of the three phases of the immune response against different classes of microorganisms (2001) (0)
This information is current as Cell Antigen Presentation in Murine Lupus Reveals Multiple Nonredundant Roles for B Specific MHC Class II Deletion − (2015) (0)
Figure 3.23, Peptides are bound to MHC class I molecules by their ends (2001) (0)
BLyS Neutralization Ablates Primary But Not Memory B Cell Pools (2008) (0)

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