Mark T Gladwin

Mark T Gladwin's AcademicInfluence.com Rankings

Mark T Gladwin

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#59

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Mark T Gladwin

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#3662

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#5875

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Engineering
Philosophy

Mark T Gladwin's Degrees

Doctorate Medicine Stanford University

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Mark T Gladwin's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics (2008) (2193)
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation (2003) (1681)
The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. (2005) (1399)
Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. (2006) (1147)
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program (2019) (785)
Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. (2007) (745)
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease (2002) (684)
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. (2005) (654)
Sickle-cell disease (2010) (647)
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. (2005) (598)
The emerging biology of the nitrite anion (2005) (557)
Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration (2007) (550)
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. (2005) (547)
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. (2002) (539)
Nitrate and nitrite in biology, nutrition and therapeutics. (2009) (526)
Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer (2007) (521)
Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. (2004) (503)
Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion (2011) (496)
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. (2005) (488)
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. (2006) (475)
Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. (2000) (445)
Pulmonary complications of sickle cell disease. (2008) (423)
Strategies to increase nitric oxide signalling in cardiovascular disease (2015) (400)
Nitrite as regulator of hypoxic signaling in mammalian physiology (2009) (395)
Intravascular hemolysis and the pathophysiology of sickle cell disease (2017) (393)
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease (2001) (377)
Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury (2008) (375)
Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy (2017) (373)
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation. (2004) (352)
Nitrite Infusion in Humans and Nonhuman Primates: Endocrine Effects, Pharmacokinetics, and Tolerance Formation (2007) (338)
Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin. (2007) (330)
Erythrocytes are the major intravascular storage sites of nitrite in human blood. (2005) (329)
Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions (2009) (325)
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis (2006) (324)
Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. (2003) (316)
Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation. (2006) (308)
Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. (2005) (297)
Nitric oxide's reactions with hemoglobin: a view through the SNO-storm (2003) (292)
Pulmonary arterial hypertension: the clinical syndrome. (2014) (289)
Unraveling the Reactions of Nitric Oxide, Nitrite, and Hemoglobin in Physiology and Therapeutics (2006) (285)
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator (2004) (278)
Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. (2001) (276)
Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. (2005) (266)
Divergent Nitric Oxide Bioavailability in Men and Women With Sickle Cell Disease (2003) (254)
The functional nitrite reductase activity of the heme-globins. (2008) (252)
Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. (2000) (252)
Regional Cerebral Hyperperfusion and Nitric Oxide Pathway Dysregulation in Fabry Disease: Reversal by Enzyme Replacement Therapy (2001) (252)
Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. (2006) (251)
Hemoglobin and the paracrine and endocrine functions of nitric oxide. (2003) (248)
Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension. (2007) (247)
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) (242)
The Reaction between Nitrite and Deoxyhemoglobin (2005) (240)
Human Neuroglobin Functions as a Redox-regulated Nitrite Reductase* (2011) (239)
Storage lesion: role of red blood cell breakdown (2011) (236)
Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. (2011) (230)
Sickle cell disease vasculopathy: a state of nitric oxide resistance. (2008) (226)
Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. (2011) (224)
Cardiovascular abnormalities in sickle cell disease. (2012) (216)
Emerging role of nitrite in human biology. (2004) (215)
Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease. (2004) (214)
Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease (2002) (211)
Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension (2005) (211)
Measurement of circulating nitrite and S-nitrosothiols by reductive chemiluminescence. (2007) (204)
Methodologies for the Sensitive and Specific Measurement of S -nitrosothiols, Iron-nitrosyls, and Nitrite in Biological Samples (2003) (199)
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin. (2007) (199)
Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial. (2011) (198)
Updated clinical classification of pulmonary hypertension. (2009) (197)
An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease. (2014) (197)
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics. (2007) (197)
Mortality in adults with sickle cell disease and pulmonary hypertension. (2012) (197)
Levels of soluble endothelium‐derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality (2005) (194)
Nitrite Potently Inhibits Hypoxic and Inflammatory Pulmonary Arterial Hypertension and Smooth Muscle Proliferation via Xanthine Oxidoreductase–Dependent Nitric Oxide Generation (2010) (191)
Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. (2009) (188)
Pathophysiology of Sickle Cell Disease. (2019) (187)
N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease. (2006) (187)
Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation (2008) (183)
SIRT3–AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction (2016) (180)
Nitrite Reductase Activity of Cytochrome c* (2008) (176)
Nitrite Anion Provides Potent Cytoprotective and Antiapoptotic Effects as Adjunctive Therapy to Reperfusion for Acute Myocardial Infarction (2008) (176)
Chronic Hyper-Hemolysis in Sickle Cell Anemia: Association of Vascular Complications and Mortality with Less Frequent Vasoocclusive Pain (2008) (175)
Nitrite Regulates Hypoxic Vasodilation via Myoglobin-Dependent Nitric Oxide Generation (2012) (172)
S-Nitrosohemoglobin Is Unstable in the Reductive Erythrocyte Environment and Lacks O2/NO-linked Allosteric Function* (2002) (170)
Reactive oxygen and nitrogen species in pulmonary hypertension. (2012) (169)
The measurement of blood and plasma nitrite by chemiluminescence: pitfalls and solutions. (2006) (167)
Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling (2013) (166)
The reaction between nitrite and hemoglobin: the role of nitrite in hemoglobin-mediated hypoxic vasodilation. (2005) (165)
The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe (2013) (163)
Nitric Oxide Scavenging by Red Blood Cells as a Function of Hematocrit and Oxygenation* (2005) (161)
Nitric oxide deficiency and endothelial dysfunction in pulmonary arterial hypertension. (2013) (161)
A network model to predict the risk of death in sickle cell disease. (2007) (155)
Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. (2013) (153)
Heme Oxygenase-1 Deficiency Accelerates Formation of Arterial Thrombosis Through Oxidative Damage to the Endothelium, Which Is Rescued by Inhaled Carbon Monoxide (2007) (152)
Research Priorities for Heart Failure With Preserved Ejection Fraction (2020) (152)
Biological activity of nitric oxide in the plasmatic compartment. (2004) (151)
Interventional Therapies for Acute Pulmonary Embolism: Current Status and Principles for the Development of Novel Evidence: A Scientific Statement From the American Heart Association. (2019) (150)
Pulmonary complications of sickle cell disease. (2012) (150)
An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy (2003) (148)
Categorization and impact of pulmonary hypertension in patients with advanced COPD. (2010) (148)
Concerted Nitric Oxide Formation and Release from the Simultaneous Reactions of Nitrite with Deoxy- and Oxyhemoglobin* (2007) (144)
The new chemical biology of nitrite reactions with hemoglobin: R-state catalysis, oxidative denitrosylation, and nitrite reductase/anhydrase. (2009) (142)
Metabolic Syndrome and the Lung. (2016) (141)
Mechanisms of hemolysis‐associated platelet activation (2013) (140)
Effect of eculizumab on haemolysis‐associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobinuria (2010) (138)
Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. (2006) (137)
Mechanisms of nitrite bioactivation. (2014) (137)
Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease. (2012) (137)
Nitrite Therapy After Cardiac Arrest Reduces Reactive Oxygen Species Generation, Improves Cardiac and Neurological Function, and Enhances Survival via Reversible Inhibition of Mitochondrial Complex I (2009) (136)
Amplified Expression Profiling of Platelet Transcriptome Reveals Changes in Arginine Metabolic Pathways in Patients With Sickle Cell Disease (2007) (134)
Chronic sickle cell lung disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension (2005) (130)
Exercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies (2010) (128)
Association Between Hemodynamic Markers of Pulmonary Hypertension and Outcomes in Heart Failure With Preserved Ejection Fraction (2018) (127)
Echocardiographic Markers of Elevated Pulmonary Pressure and Left Ventricular Diastolic Dysfunction Are Associated With Exercise Intolerance in Adults and Adolescents With Homozygous Sickle Cell Anemia in the United States and United Kingdom (2011) (126)
Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis (2009) (124)
Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study. (2017) (123)
Cardiopulmonary complications of sickle cell disease: role of nitric oxide and hemolytic anemia. (2005) (122)
Nitrite Reductase and Nitric-oxide Synthase Activity of the Mitochondrial Molybdopterin Enzymes mARC1 and mARC2* (2014) (120)
Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease. (2005) (119)
Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity. (1999) (117)
Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency (2008) (116)
Vasculopathy and pulmonary hypertension in sickle cell disease. (2015) (115)
Severity of pulmonary hypertension during vaso‐occlusive pain crisis and exercise in patients with sickle cell disease (2007) (114)
Dexamethasone Alters Arachidonate Release from Human Epithelial Cells by Induction of p11 Protein Synthesis and Inhibition of Phospholipase A2 Activity* (1999) (110)
Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) (109)
Cardiovascular complications and risk of death in sickle-cell disease (2016) (106)
Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure. (2006) (106)
PULMONARY HYPERTENSION IN SICKLE CELL DISEASE: Relevance to Children (2007) (106)
Copper dependence of the biotin switch assay: modified assay for measuring cellular and blood nitrosated proteins. (2008) (102)
Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders. (2008) (102)
Risk Factors for Death in 632 Patients with Sickle Cell Disease in the United States and United Kingdom (2014) (101)
Testosterone‐dependent sex differences in red blood cell hemolysis in storage, stress, and disease (2016) (100)
Circulating Blood Endothelial Nitric Oxide Synthase Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis (2013) (99)
Pulmonary complications of sickle cell anemia. A need for increased recognition, treatment, and research. (2001) (99)
Sickle cell disease and pulmonary hypertension in Africa: A global perspective and review of epidemiology, pathophysiology, and management (2008) (97)
Differences in the clinical and genotypic presentation of sickle cell disease around the world. (2014) (96)
Prevalence and risk factors for pulmonary artery systolic hypertension among sickle cell disease patients in Nigeria (2008) (95)
Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response. (2009) (94)
Crises in Sickle Cell Disease. (2016) (94)
Nitrite mediates cytoprotection after ischemia/reperfusion by modulating mitochondrial function (2009) (94)
Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia (2014) (94)
Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats. (2011) (92)
Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases (2018) (92)
The acute chest syndrome in sickle cell disease. Possible role of nitric oxide in its pathophysiology and treatment. (1999) (89)
Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling. (2011) (89)
Cerebrovascular disease associated with sickle cell pulmonary hypertension (2006) (89)
Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli. (2016) (89)
Erythroid DAMPs drive inflammation in SCD. (2014) (88)
The hydrogen highway to reperfusion therapy (2007) (87)
Erythrocytes and Vascular Function: Oxygen and Nitric Oxide (2018) (86)
Noninvasive Determination of Spatially Resolved and Time-Resolved Tissue Perfusion in Humans During Nitric Oxide Inhibition and Inhalation by Use of a Visible-Reflectance Hyperspectral Imaging Technique (2001) (86)
The Perfusion Paradox and Vascular Instability in Sickle Cell Disease (2004) (86)
Risk factors for mortality in adult patients with sickle cell disease: a meta-analysis of studies in North America and Europe (2017) (85)
NO contest: nitrite versus S-nitroso-hemoglobin. (2004) (85)
Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemias. (2006) (85)
Markers of severe vaso-occlusive painful episode frequency in children and adolescents with sickle cell anemia. (2012) (83)
Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy era (2012) (82)
Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease (2009) (82)
Nitric oxide scavenging by red cell microparticles. (2013) (81)
Low-dose intravenous nitrite improves hemodynamics in a canine model of acute pulmonary thromboembolism. (2006) (80)
Measurements of nitric oxide on the heme iron and β-93 thiol of human hemoglobin during cycles of oxygenation and deoxygenation (2003) (80)
Pulmonary hypertension in hemolytic disorders: pulmonary vascular disease: the global perspective. (2010) (79)
Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans. (2012) (78)
Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 months of follow up in children and adolescents with sickle cell anemia (2011) (78)
Vaping-Associated Acute Lung Injury: A Case Series. (2019) (78)
Bad Blood: The risks of red cell storage (2010) (77)
Hemoglobin oxygen fractional saturation regulates nitrite-dependent vasodilation of aortic ring bioassays. (2007) (77)
Pulmonary hypertension in sickle cell disease: mechanisms, diagnosis, and management. (2005) (77)
AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia. (2016) (77)
Measurement of Nitric Oxide Levels in the Red Cell (2006) (77)
Plasma thrombospondin‐1 is increased during acute sickle cell vaso‐occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates (2012) (76)
Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxidation and the NO resistance syndrome. (2006) (76)
Haemoglobin: NO transporter, NO inactivator or NOne of the above? (2002) (75)
Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity. (2014) (73)
Imaging hemoglobin oxygen saturation in sickle cell disease patients using noninvasive visible reflectance hyperspectral techniques: effects of nitric oxide. (2003) (73)
Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction. (2016) (73)
Mechanisms of Human Erythrocytic Bioactivation of Nitrite* (2014) (73)
Haldane, hot dogs, halitosis, and hypoxic vasodilation: the emerging biology of the nitrite anion. (2004) (72)
Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy. (2008) (72)
Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC. (2016) (71)
Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes. (2015) (70)
14-3-3 Binding and Phosphorylation of Neuroglobin during Hypoxia Modulate Six-to-Five Heme Pocket Coordination and Rate of Nitrite Reduction to Nitric Oxide* (2011) (70)
Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity (2020) (69)
Effects of nitrite on modulating ROS generation following ischemia and reperfusion. (2009) (69)
Nitrite and nitrate chemical biology and signalling (2018) (68)
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2017) (68)
Nitric oxide therapy in sickle cell disease. (2001) (68)
Characterization of Right Ventricular Remodeling in Pulmonary Hypertension Associated With Patient Outcomes by 3-Dimensional Wall Motion Tracking Echocardiography (2015) (66)
Sodium nitrite promotes regional blood flow in patients with sickle cell disease: a phase I/II study (2008) (65)
Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. (2010) (65)
Angiogenic and Inflammatory Markers of Cardiopulmonary Changes in Children and Adolescents with Sickle Cell Disease (2009) (65)
Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. (2014) (65)
A pilot study of electronic directly observed therapy to improve hydroxyurea adherence in pediatric patients with sickle‐cell disease (2014) (64)
Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism. (2009) (64)
Hematologic, biochemical, and cardiopulmonary effects of l‐arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy (2009) (64)
Nitrite reductase activity of nonsymbiotic hemoglobins from Arabidopsis thaliana. (2012) (63)
Prospective echocardiography assessment of pulmonary hypertension and its potential etiologies in children with sickle cell disease. (2009) (63)
Pulmonary hypertension and NO in sickle cell. (2010) (63)
Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics. (2013) (63)
Endothelial Progenitor Cell Mobilization and Increased Intravascular Nitric Oxide in Patients Undergoing Cardiac Rehabilitation (2007) (62)
Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop (2016) (61)
CCR5 as a Treatment Target in Pulmonary Arterial Hypertension (2014) (61)
Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report. (2017) (60)
Pathogenesis and treatment of acute chest syndrome of sickle-cell anaemia (2000) (60)
Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease. (2009) (60)
Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients (2009) (59)
A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia (2012) (59)
Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy (2015) (58)
Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease (2008) (58)
Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function. (2015) (58)
Selective Recapitulation of Conserved and Nonconserved Regions of Putative NOXA1 Protein Activation Domain Confers Isoform-specific Inhibition of Nox1 Oxidase and Attenuation of Endothelial Cell Migration* (2013) (57)
Mixed haematopoietic chimerism for sickle cell disease prevents intravascular haemolysis (2007) (57)
Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review. (2006) (56)
Shining a light on tissue NO stores: near infrared release of NO from nitrite and nitrosylated hemes. (2009) (56)
Role of the red blood cell in nitric oxide homeostasis and hypoxic vasodilation. (2006) (56)
Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis. (2008) (56)
Platelet Extracellular Vesicles Drive Inflammasome-IL1β-dependent Lung Injury in Sickle Cell Disease. (2020) (56)
Nitrite as an intrinsic signaling molecule (2005) (55)
Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction (2017) (55)
Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling (2017) (54)
Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS‐III—Omics (2018) (54)
Home Nitric Oxide Therapy for COVID-19 (2020) (54)
Hemolytic anemia-associated pulmonary hypertension of sickle cell disease and the nitric oxide/arginine pathway. (2003) (53)
The globin superfamily: functions in nitric oxide formation and decay (2014) (53)
Electron Paramagnetic Resonance Analysis of Nitrosylhemoglobin in Humans during NO Inhalation* (2005) (52)
Nitric oxide, hemolysis, and the red blood cell storage lesion: interactions between transfusion, donor, and recipient (2012) (52)
Mechanisms of Slower Nitric Oxide Uptake by Red Blood Cells and Other Hemoglobin-containing Vesicles* (2011) (52)
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation. (2009) (52)
NT‐pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease (2011) (51)
Disorders of ciliary motility. (2001) (51)
Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia (2014) (49)
Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction (2013) (48)
Increased pulmonary pressures and myocardial wall stress in children with severe malaria. (2010) (48)
Nitrite Reductase Activity of Hemoglobin S (Sickle) Provides Insight into Contributions of Heme Redox Potential Versus Ligand Affinity* (2008) (47)
The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1 (2017) (46)
Characterization of Whole Blood Gene Expression Profiles as a Sequel to Globin mRNA Reduction in Patients with Sickle Cell Disease (2009) (46)
Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells (2016) (45)
Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia. (2010) (45)
Exploring the Mechanisms of the Reductase Activity of Neuroglobin by Site-Directed Mutagenesis of the Heme Distal Pocket (2015) (45)
Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells. (2014) (45)
The relationship between pulmonary emphysema and kidney function in smokers. (2012) (45)
Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning (2016) (45)
Nitrate-nitrite-nitric oxide pathway in pulmonary arterial hypertension therapeutics. (2012) (44)
Abnormal Pulmonary Function and Associated Risk Factors in Children and Adolescents With Sickle Cell Anemia (2014) (44)
Genetic determinants of haemolysis in sickle cell anaemia (2013) (44)
Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS‐III RBC‐Omics study (2018) (43)
Mechanism of faster NO scavenging by older stored red blood cells (2014) (43)
Hemoglobin as a nitrite anhydrase: modeling methemoglobin-mediated N2O3 formation. (2011) (43)
Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Nebulized Sodium Nitrite (AIR001) Following Repeat-Dose Inhalation in Healthy Subjects (2014) (42)
Chemiluminescent detection of S-nitrosated proteins: comparison of tri-iodide, copper/CO/cysteine, and modified copper/cysteine methods. (2008) (41)
Redefining pulmonary hypertension. (2017) (40)
Hemoglobin as a nitrite reductase regulating red cell-dependent hypoxic vasodilation. (2005) (40)
Nitrite Reduces Acute Lung Injury and Improves Survival in a Rat Lung Transplantation Model (2012) (40)
Effects of dietary nitrate on blood pressure. (2007) (39)
The detection of the nitrite reductase and NO-generating properties of haemoglobin by mitochondrial inhibition. (2011) (39)
Hemolysis-associated hypercoagulability in sickle cell disease: the plot (and blood) thickens! (2008) (39)
Effects of S-Nitrosation and Cross-Linking of Hemoglobin on Hypoxic Pulmonary Vasoconstriction in Isolated Rat Lungs (2002) (38)
Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury. (2014) (38)
Blood, sweat, and tears: Red Blood Cell‐Omics study objectives, design, and recruitment activities (2018) (38)
Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension. (2013) (38)
Pulmonary hypertension: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. (2014) (38)
In-gel detection of S-nitrosated proteins using fluorescence methods. (2008) (37)
Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity. (2017) (36)
Liver injury is associated with mortality in sickle cell disease (2015) (36)
Low NO Concentration Dependence of Reductive Nitrosylation Reaction of Hemoglobin* (2012) (35)
Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System. (2017) (35)
Frequent blood donations alter susceptibility of red blood cells to storage‐ and stress‐induced hemolysis (2018) (35)
Pulmonary vascular lesions are common in SIV- and SHIV-env-infected macaques. (2011) (34)
Clinical correlates of acute pulmonary events in children and adolescents with sickle cell disease (2013) (34)
Myocardial protection by nitrite: evidence that this reperfusion therapeutic will not be lost in translation. (2008) (34)
Effects of nitric oxide and its congeners on sickle red blood cell deformability (2015) (34)
Association of G6PD202A,376G with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia (2010) (34)
Perspectives on Cardiopulmonary Critical Care for Patients With COVID‐19: From Members of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation (2020) (34)
Novel Targets of Drug Treatment for Pulmonary Hypertension (2015) (34)
Aging and Lung Disease. Clinical Impact and Cellular and Molecular Pathways. (2015) (33)
Ancestry of African Americans with sickle cell disease. (2011) (33)
Effects of aged stored autologous red blood cells on human plasma metabolome. (2019) (33)
Segmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension. (2010) (33)
Evidence mounts that nitrite contributes to hypoxic vasodilation in the human circulation. (2008) (33)
Hemolytic anemia-associated pulmonary hypertension in sickle cell disease. (2005) (32)
Perivascular T-cell infiltration leads to sustained pulmonary artery remodeling after endothelial cell damage. (2011) (32)
Prediction of Fetal Hemoglobin in Sickle Cell Anemia Using an Ensemble of Genetic Risk Prediction Models (2014) (32)
Lopinavir-ritonavir: effects on endothelial cell function in healthy subjects. (2006) (32)
Methodological vexation about thiol oxidation versus S-nitrosation -- a commentary on "An ascorbate-dependent artifact that interferes with the interpretation of the biotin-switch assay". (2006) (31)
Vascular biology: Nitric oxide caught in traffic (2012) (31)
Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice. (2019) (31)
Clinical Outcomes and Mortality Impact of Hyperbaric Oxygen Therapy in Patients With Carbon Monoxide Poisoning (2018) (31)
Increased nitrite reductase activity of fetal versus adult ovine hemoglobin. (2009) (31)
OXIDANT-INDUCED CELL DEATH IN RESPIRATORY EPITHELIAL CELLS IS DUE TO DNA DAMAGE AND LOSS OF ATP (2002) (30)
Nitrite exerts potent negative inotropy in the isolated heart via eNOS-independent nitric oxide generation and cGMP-PKG pathway activation. (2009) (30)
Haptoglobin improves shock, lung injury, and survival in canine pneumonia. (2018) (29)
Mechanical ventilation of the patient with severe chronic obstructive pulmonary disease (1998) (29)
Elevated Pulse Pressure is Associated with Hemolysis, Proteinuria and Chronic Kidney Disease in Sickle Cell Disease (2014) (29)
Cardiovascular complications in patients with sickle cell disease. (2017) (29)
Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report (2019) (29)
Pathophysiology of a Sickle Cell Trait Mouse Model: Human αβS Transgenes with One Mouse β-Globin Allele (2001) (28)
Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease (2013) (28)
Effect of nitric oxide and nitric oxide donors on red blood cell oxygen transport (2000) (28)
Red Blood Cells Store and Release Interleukin-33 (2015) (28)
Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice (2016) (27)
Expression of Regulatory Platelet MicroRNAs in Patients with Sickle Cell Disease (2013) (27)
The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiology. (2008) (26)
Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation (2010) (26)
Multi-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage. (2021) (26)
Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences. (2016) (26)
Effects of S-nitrosation of hemoglobin on hypoxic pulmonary vasoconstriction and nitric oxide flux. (2001) (26)
Potential therapeutic action of nitrite in sickle cell disease (2017) (25)
Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration (2019) (25)
Nitric oxide (NO) in normal and hypoxic vascular regulation of the spiny dogfish, Squalus acanthias. (2005) (24)
Harnessing the nitrate-nitrite-nitric oxide pathway for therapy of heart failure with preserved ejection fraction. (2015) (24)
Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHLR200W mutation (Chuvash polycythemia) (2012) (24)
Effects of Iron Nitrosylation on Sickle Cell Hemoglobin Solubility* (2002) (24)
Inhalation of NO during myocardial ischemia reduces infarct size and improves cardiac function (2012) (24)
Safety and Efficacy of Sildenafil Therapy for Doppler-Defined Pulmonary Hypertension in Patients with Sickle Cell Disease: Preliminary Results of the Walk-PHaSST Clinical Trial. (2009) (24)
Downsides to the nitrate–nitrite–nitric oxide pathway in physiology and therapeutics? Reply from Lundberg, Weitzberg and Gladwin (2008) (24)
Emerging therapeutics in pulmonary hypertension. (2018) (24)
Revisiting the hyperhemolysis paradigm. (2015) (24)
The Ligand Binding Battle at Cytochrome c Oxidase: How NO Regulates Oxygen Gradients in Tissue (2009) (23)
Xanthine Oxidoreductase Function Contributes to Normal Wound Healing (2015) (23)
Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction. (2013) (23)
Pulmonary vascular effects of red blood cells containing S-nitrosated hemoglobin. (2004) (23)
No evidence of hemoglobin damage by SARS-CoV-2 infection (2020) (23)
Epidermal Growth Factor Induces p11 Gene and Protein Expression and Down-regulates Calcium Ionophore-induced Arachidonic Acid Release in Human Epithelial Cells* (2002) (23)
Nitric oxide pathology and therapeutics in sickle cell disease. (2018) (23)
Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO‐1 induction (2011) (22)
Nebulized nitrite protects rat lung grafts from ischemia reperfusion injury. (2013) (22)
Pitfalls in measuring NO bioavailability using NOx. (2015) (22)
Cellular, Pharmacological, and Biophysical Evaluation of Explanted Lungs from a Patient with Sickle Cell Disease and Severe Pulmonary Arterial Hypertension (2013) (22)
Lactate dehydrogenase and hemolysis in sickle cell disease. (2013) (22)
Opioid-Associated Out-of-Hospital Cardiac Arrest: Distinctive Clinical Features and Implications for Health Care and Public Responses: A Scientific Statement From the American Heart Association (2021) (22)
BMP 9/10 in Pulmonary Vascular Complications of Liver Disease. (2020) (21)
Normoxic cyclic GMP-independent oxidative signaling by nitrite enhances airway epithelial cell proliferation and wound healing. (2012) (21)
Inorganic nitrite improves components of the metabolic syndrome independent of weight change in a murine model of obesity and insulin resistance (2015) (21)
Injection drug use as a "second hit" in the pathogenesis of HIV-associated pulmonary hypertension. (2012) (21)
Antioxidant therapy for the treatment of pulmonary hypertension. (2013) (21)
Renal Pathology in Hemizygous Sickle Cell Mice (2002) (21)
An electron paramagnetic resonance study of the affinity of nitrite for methemoglobin. (2010) (21)
The New Chemical Biology of Nitrite Reactions with Hemoglobin: R-State Catalysis, Oxidative Denitrosylation, and Nitrite Reductase/Anhydrase (2009) (20)
The genetics of hemoglobin A2 regulation in sickle cell anemia (2014) (20)
Adenosine receptor crossroads in sickle cell disease (2011) (20)
Mouse Genome‐Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor (2017) (20)
Piloting and implementation of quality assessment and quality control procedures in RBC‐Omics: a large multi‐center study of red blood cell hemolysis during storage (2019) (20)
Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage. (2014) (20)
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. (2021) (20)
The Nitrate–Nitrite–Nitric Oxide Pathway in Mammals (2011) (19)
Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate (2017) (19)
Physiologic, pathologic and therapeutic implications for hemoglobin interactions with nitric oxide. (2004) (19)
Biomarker signatures of sickle cell disease severity. (2017) (19)
Isolated right ventricular dysfunction in patients with human immunodeficiency virus. (2014) (19)
Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension. (2018) (19)
Mitochondrial Complex I Reversible S-Nitrosation Improves Bioenergetics and Is Protective in Parkinson's Disease. (2018) (19)
Sickle cell disease: at the crossroads of pulmonary hypertension and diastolic heart failure (2019) (19)
Clonal hematopoiesis in sickle cell disease (2021) (18)
Nitric Oxide‐Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease (2017) (18)
Retinoic acid reduces p11 protein levels in bronchial epithelial cells by a posttranslational mechanism. (2000) (18)
The potential of Angeli's salt to decrease nitric oxide scavenging by plasma hemoglobin. (2008) (18)
Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass (2017) (18)
Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation. (2020) (18)
Mechanisms and Clinical Complications of Hemolysis in Sickle Cell Disease and Thalassemia (2009) (17)
Predictors of osteoclast activity in patients with sickle cell disease (2011) (17)
Donor genetic and nongenetic factors affecting red blood cell transfusion effectiveness (2021) (17)
Insights into the pulmonary vascular complications of heart failure with preserved ejection fraction (2018) (17)
Is Nitrite the Circulating Endocrine Effector of Remote Ischemic Preconditioning? (2014) (17)
Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction. (2019) (17)
Effects of a Single Sickling Event on the Mechanical Fragility of Sickle Cell Trait Erythrocytes (2010) (17)
End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings. (2019) (16)
Doppler-defined pulmonary hypertension in medical intensive care unit patients: Retrospective investigation of risk factors and impact on mortality (2011) (16)
An Of fi cial American Thoracic Society Clinical Practice Guideline : Diagnosis , Risk Strati fi cation , and Management of Pulmonary Hypertension of Sickle Cell Disease (2014) (16)
Update on pulmonary hypertension 2009. (2010) (16)
Mechanisms for cellular NO oxidation and nitrite formation in lung epithelial cells. (2013) (16)
Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial. (2021) (16)
Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction (2020) (16)
Interferon-γ Induces p11 Gene and Protein Expression in Human Epithelial Cells through Interferon-γ-activated Sequences in the p11Promoter* (2003) (15)
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed (2022) (15)
In vivo reduction of cell‐free methemoglobin to oxyhemoglobin results in vasoconstriction in canines (2013) (15)
Pathophysiology of a sickle cell trait mouse model: human alpha(beta)(S) transgenes with one mouse beta-globin allele. (2001) (15)
Under Pressure to Clarify Pulmonary Hypertension Clinical Risk. (2017) (15)
Senicapoc trial results support the existence of different sub‐phenotypes of sickle cell disease with possible drug‐induced phenotypic shifts (2011) (15)
Liver to lung microembolic NETs promote Gasdermin-D-dependent inflammatory lung injury in Sickle Cell Disease. (2022) (15)
A neuroglobin-based high-affinity ligand trap reverses carbon monoxide–induced mitochondrial poisoning (2020) (15)
Traffic Light: prognosis-based eligibility for clinical trials of hematopoietic SCT in adults with sickle cell anemia (2015) (15)
High Definition Contrast-Enhanced MR Imaging in Paroxysmal Nocturnal Hemoglobinuria (PNH) Suggests a High Frequency of Subclinical Thrombosis. (2006) (15)
Unraveling the hemolytic subphenotype of sickle cell disease (2005) (15)
Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease (2015) (14)
Sulfite Oxidase Catalyzes Single-Electron Transfer at Molybdenum Domain to Reduce Nitrite to Nitric Oxide. (2015) (14)
Evidence mounts that red cells and deoxyhemoglobin can reduce nitrite to bioactive NO to mediate intravascular endocrine NO signaling: commentary on "Anti-platelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex". (2013) (14)
Sodium Nitrite Blocks the Activity of Aminoglycosides against Pseudomonas aeruginosa Biofilms (2015) (14)
Red blood cell endothelial nitric oxide synthase does not modulate red blood cell storage hemolysis (2013) (14)
Interferon-gamma induces p11 gene and protein expression in human epithelial cells through interferon-gamma-activated sequences in the p11 promoter. (2003) (14)
NT‐proBNP as a marker of cardiopulmonary status in sickle cell anaemia in Africa (2010) (14)
Tricuspid regurgitation velocity and other biomarkers of mortality in children, adolescents and young adults with sickle cell disease in the United States: The PUSH study (2020) (14)
Pulmonary hypertension in patients with hemoglobinopathies: could a mechanism for dysfunction provide an avenue for novel therapeutics? (2005) (13)
Nitric Oxide Consumption and Pulmonary Hypertension in Patients with Paroxysmal Nocturnal Hemoglobinuria. (2005) (13)
Inorganic nitrite bioactivation and role in physiological signaling and therapeutics (2019) (13)
Apixaban or Rivaroxaban Versus Warfarin for Treatment of Submassive Pulmonary Embolism After Catheter-Directed Thrombolysis (2018) (13)
Nitric oxide transport on sickle cell hemoglobin: Where does it bind? (2001) (13)
Hemolysis and hemolysis‐related complications in females vs. males with sickle cell disease (2018) (13)
Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin. (2012) (13)
Noninfectious and Nonneoplastic Conditions Associated with Human Immunodeficiency Virus Infection (2016) (13)
Clinical Characterization of E-cigarette, or Vaping, Product Use Associated Lung Injury in 36 Patients in Pittsburgh, PA. (2020) (12)
Pulmonary Hypertension in Sickle Cell Disease: Cardiopulmonary Evaluation and Response to Chronic Phosphodiesterase 5 Inhibitor Therapy. (2004) (12)
Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice. (2019) (12)
Associations of α-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts. (2017) (11)
Direct sGC activation bypasses NO scavenging reactions of intravascular free oxy-hemoglobin and limits vasoconstriction. (2013) (11)
Prevalence, risk factors and mortality of pulmonary hypertension defined by right heart catheterization in patients with sickle cell disease (2011) (11)
First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno-Occlusive Disease (2013) (11)
Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism (2018) (11)
Elevated NT-Pro-Brain Natriuretic Peptide Level Is Independently Associated with All-Cause Mortality in HIV-Infected Women in the Early and Recent HAART Eras in the Women’s Interagency HIV Study Cohort (2015) (11)
Translational Advances in the Field of Pulmonary Hypertension Bench to Bedside: How Fundamental Discoveries in Science Are Advancing Our Understanding and Therapy of Pulmonary Arterial Hypertension. (2017) (11)
Metabolic Syndrome Mediates ROS-miR-193b-NFYA–Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction (2021) (10)
CCR 5 as a Treatment Target in Pulmonary Arterial Hypertension (2014) (10)
Hemodialysis hyperhemolysis. A novel mechanism of endothelial dysfunction and cardiovascular risk? (2010) (10)
NO solutions? (2002) (10)
Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite. (2021) (10)
Effects of Oral Sodium Nitrite on Blood Pressure, Insulin Sensitivity, and Intima-Media Arterial Thickening in Adults With Hypertension and Metabolic Syndrome (2020) (10)
CT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension (2008) (10)
GWAS of osmotic hemolysis in 12,352 healthy blood donors identifies red cell genetic variants associated with steady state hemolysis in patients with sickle cell disease (2017) (9)
Update in Pulmonary Vascular Diseases 2014. (2015) (9)
Endothelial chronic destructive pulmonary disease (E-CDPD): is endothelial apoptosis a subphenotype or prequel to COPD? (2011) (9)
Nitrosyl Myoglobins and Their Nitrite Precursors: Crystal Structural and Quantum Mechanics and Molecular Mechanics Theoretical Investigations of Preferred Fe -NO Ligand Orientations in Myoglobin Distal Pockets. (2018) (9)
Novel Function of Sulfite Oxidase as a Nitrite Reductase that Generates Nitric Oxide (2010) (9)
Erythrocytic bioactivation of nitrite and its potentiation by far-red light (2018) (9)
Atorvastatin Therapy Restores Nitric Oxide-Dependent Vascular Responsiveness in Patients with Sickle Cell Disease. (2004) (8)
The workup of stridor: virtual bronchoscopy as a complementary technique in the diagnosis of subglottic stenosis. (2007) (8)
Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Down Regulation of sGC and Contributes to Exercise-Induced Pulmonary Hypertension in HFpEF. (2021) (8)
The zebrafish Cytochrome b5/Cytochrome b5 reductase/NADH system efficiently reduces Cytoglobins 1 and 2 - Conserved activity of Cytochrome b5/Cytochrome b5 reductases during vertebrate evolution. (2019) (8)
Thrombospondin‐1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia (2017) (8)
How Red Blood Cells Process Nitric Oxide: Evidence for the Nitrite Hypothesis (2017) (8)
Metformin Therapy for Pulmonary Hypertension Associated with HFpEF versus PAH. (2018) (8)
Rationale and design of mDOT-HuA study: a randomized trial to assess the effect of mobile-directly observed therapy on adherence to hydroxyurea in adults with sickle cell anemia in Tanzania (2016) (8)
Working Group on Cellular and Molecular Mechanisms of Right Heart Failure Right Ventricular Function and Failure : Report of a National Heart , Lung , and Blood (2006) (8)
Sleep phenotype in the Townes mouse model of sickle cell disease (2018) (8)
Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery (2021) (7)
Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years’ experience (2017) (7)
Nitrite improves heart regeneration in zebrafish. (2019) (7)
The role of red blood cells and hemoglobin-nitric oxide interactions on blood flow. (2008) (7)
An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels (2018) (7)
Improved quantitative detection of biotin‐labeled red blood cells by flow cytometry (2019) (7)
The CYB5R3c.350C>G and G6PD A alleles modify severity of anemia in malaria and sickle cell disease (2020) (7)
Computed Tomography Correlates with Cardiopulmonary Hemodynamics in Pulmonary Hypertension in Adults with Sickle Cell Disease (2014) (7)
Shining a Light on Carbon Monoxide Poisoning. (2015) (7)
Nitrite-NO bailout for a NOS complex too big to fail (2011) (7)
What is the role of screening for pulmonary hypertension in adults and children with sickle cell disease? (2017) (7)
Elevated N-Terminal Pro-Brain Natriuretic Peptide Is Associated with Mortality in Tobacco Smokers Independent of Airflow Obstruction (2011) (7)
Natriuretic Peptide Levels Correlate with Pulmonary Pressures and Prospective Mortality in SCD: Use of This Biomarker To Identify Prevalence and Mortality of Pulmonary Hypertension in the MSH Cohort. (2005) (6)
Pulmonary hypertension in sickle cell disease. (2011) (6)
P205 – Sulfite oxidase catalyzes single electron transfer at molybdenum domain to reduce nitrite to nitric oxide (2014) (6)
Oral Arginine Increases Erythrocyte Glutathione Levels in Sickle Cell Disease: Implications for Pulmonary Hypertension. (2006) (6)
Relaxin Inhibits Ventricular Arrhythmia and Asystole in Rats With Pulmonary Arterial Hypertension (2021) (6)
Polycythemia, HIF-1alpha and pulmonary hypertension in Chuvash. (2006) (6)
Redox sensor properties of human cytoglobin allosterically regulate heme pocket reactivity. (2020) (6)
Acute on Chronic Pulmonary Hypertension in Patients with Sickle Cell Disease. (2004) (6)
Impact of different standard red blood cell storage temperatures on human and canine RBC hemolysis and chromium survival (2018) (6)
The Effects of Inhaled Sodium Nitrite on Pulmonary Vascular Impedance in Patients with Pulmonary Hypertension Associated with HFpEF. (2020) (6)
Correction to Exploring the Mechanisms of the Reductase Activity of Neuroglobin by Site-Directed Mutagenesis of the Heme Distal Pocket (2015) (6)
Eculizumab Reduces Pulmonary Hypertension through Inhibition of Hemolysis-Associated Nitric Oxide Consumption in Patients with Paroxysmal Nocturnal Hemoglobinuria (2008) (6)
Intravascular hemolysis triggers ADP-mediated generation of platelet-rich thrombi in pre-capillary pulmonary arterioles. (2020) (6)
The Arginine-to-Ornithine Ratio: Biomarker of Arginase Activity and Predictor of Mortality in Sickle Cell Disease. (2004) (6)
Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children with asthma. (2019) (6)
Carbonic anhydrase II does not regulate nitrite‐dependent nitric oxide formation and vasodilation (2020) (6)
Nitrite therapeutics: back to the future. (2005) (5)
Hemolysis-Associated Endothelial Dysfunction and Pulmonary Hypertension, an Emerging Cause of Death in the Hemoglobinopathies (2007) (5)
Red Blood Cell Storage In Pediatric Transfer Bags Is Correlated With Increased Levels Of Hemolysis and Altered Osmotic Fragility (2013) (5)
Predictors of Mortality in Children and Adolescents with Sickle Cell Disease: The PUSH Study (2011) (5)
Increased consumption and vasodilatory effect of nitrite during exercise. (2016) (5)
Training pulmonary researchers to span the bench-to-bedside "Valley of Death". (2014) (5)
Heme Protein Metabolism of NO and Nitrite (2017) (5)
NT-Pro Brain Natriuretic Peptide Levels and the Risk of Stroke and Death in the Cooperative Study of Sickle Cell Disease. (2009) (5)
Nitrite Attenuates Mitochondrial Impairment And Vascular Permeability Induced by Ischemia-Reperfusion Injury in Lung. (2020) (5)
Current good manufacturing practices-compliant manufacture and measurement of biotin-labeled red blood cells. (2019) (5)
Severe pulmonary hypertension in an adolescent with sickle cell disease (2008) (5)
Evaluation Of Sildenafil Therapy For Patients With Sickle Cell Disease And Increased Tricuspid Regurgitant Velocity: Preliminary Results Of The Walk-PHaSST Trial (2010) (5)
Pulmonary artery segmentation and quantification in sickle cell associated pulmonary hypertension (2008) (5)
Cytoglobin at the Crossroads of Vascular Remodeling. (2017) (5)
Update in Pulmonary Vascular Diseases and Right Ventricular Dysfunction in 2019. (2020) (5)
Update in Pulmonary Vascular Disease 2015. (2016) (5)
Novel genetic determinants of telomere length from a multi-ethnic analysis of 75,000 whole genome sequences in TOPMed (2019) (5)
Impaired Bile Secretion Promotes Hepatobiliary Injury in Sickle Cell Disease (2020) (5)
Reply to 'Nitrite–methemoglobin inadequate for hypoxic vasodilation' (2009) (5)
A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease. (2016) (4)
P66: Nebulized inhaled nitrite (AIR001) for pulmonary arterial hypertension: Studies to determine safety, pharmacokinetics, and maximum tolerated dose, lack of pharmacodynamic interaction with sildenafil and optimal nebulizer device (2013) (4)
P6: Th1/Th2 Cytokines promote Nitrite/H2O2-mediated tyrosine nitration in airway epithelial cells: Potential role in severe asthma (2013) (4)
Clinical Impact and Cellular and Molecular Pathways (2015) (4)
Current and future therapies of sickle cell anemia: an historical perspective. (2008) (4)
Tri-iodide and vanadium chloride based chemiluminescent methods for quantification of nitrogen oxides. (2022) (4)
Prevalence of Pulmonary Hypertension and Renal Dysfunction by Systemic Blood Pressure Categories in Sickle Cell Disease. (2005) (4)
Hemolysis-associated pulmonary hypertension in sickle cell disease and thalassemia (2011) (4)
P62: Sulfite oxidase catalyzes single electron transfer at molybdenum domain to reduce nitrite to NO (2013) (4)
Renal Disease in Sickle Cell: Clinically Varied and Associated with Increased Mortality (2012) (4)
nitric oxide Pulmonary Arterial Hypertension The Clinical Syndrome (2014) (4)
Right ventricular load and contractility in HIV-associated pulmonary hypertension (2021) (4)
Exploring New Therapeutic Pathways in Pulmonary Hypertension: Metabolism, Proliferation, and Personalized Medicine. (2020) (4)
The Mechanism of Hemolysis in Sickle Cell Anemia. (2008) (4)
Chapter 12 – Hemolytic Anemia Associated Pulmonary Hypertension (2006) (4)
Rare genetic variants explain missing heritability in smoking (2022) (4)
ABI-009, nab-Sirolimus, an mTOR Inhibitor with High Lung Accumulation in Preclinical Models Is Active in Patients with Severe Pulmonary Arterial Hypertension (2019) (3)
Nitrite and Heme Globins (2010) (3)
Hemodynamic Parameters Predict Mortality In Sickle Cell Disease-Related Pulmonary Hypertension (2010) (3)
Effect of age, sex or frequent blood donations on donors' ferritin levels and red blood cell storage stability (2016) (3)
Correlation Between Female Gender and the Red Blood Cell Propensity to Hemolyze Under Various Stresses (2011) (3)
Intra-Donor Reproducibility and Changes in Hemolytic Parameters During RBC Storage (Meeting Abstract: SP44) (2015) (3)
Response by Lai and Gladwin to Letter Regarding Article, "SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction". (2016) (3)
Does eNOS stand for erythrocytic NO synthase (2006) (3)
Pulmonary hypertension of sickle cell disease beyond classification constraints. (2014) (3)
S-NITROSOHEMOGLOBIN: AN ALLOSTERIC MEDIATOR OF NO GROUP FUNCTION IN MAMMALIAN VASCULATURE (2004) (3)
Automated Measurement of Blood Vessels in Tissues from Microscopy Images (2016) (3)
Arginine for mitochondrial oxidative enzymopathy. (2020) (3)
Brief Report: Hydroxychloroquine does not induce hemolytic anemia or organ damage in a “humanized” G6PD A- mouse model (2020) (3)
Do BRD(4)S of a Feather Flock Together? How an Inflammation-Driven Epigenetic Regulator May Link Pulmonary Hypertension and Coronary Artery Disease. (2017) (3)
Hemolysis-mediated Toxicity during Cardiopulmonary Bypass Ameliorated by Inhaled Nitric Oxide Gas. (2018) (3)
Unraveling restrictive chronic lung disease in sickle cell disease. (2013) (3)
Dietary nitrates and nitrites modulate vascular intimal hyperplasia (2010) (3)
The Sickle Cell-Pulmonary Hypertension Screening Study: ECHO Findings at Two-Years of Follow Up. (2005) (3)
Mechanistic Insights into Cell-free Hemoglobin-induced Injury During Septic Shock. (2021) (2)
Identifying adolescent and young adult patients with sickle cell disease at highest risk of death (2020) (2)
Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia (2019) (2)
Arginine Metabolism, Pulmonary Hypertension, and Sickle Cell Disease—Reply (2005) (2)
Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases (2021) (2)
PATIENTS WITH SEVERE PULMONARY ARTERIAL HYPERTENSION TREATED WITH ABI-009, NAB-SIROLIMUS, AN MTOR INHIBITOR: INTERIM RESULTS FROM A PHASE 1 CLINICAL TRIAL (2019) (2)
Arginine Metabolism and Nitric Oxide Bioavailability in Sickle Cell Disease (2010) (2)
concentration but not increased haemolysis in patients with sickle cell anaemia (2010) (2)
Potential Contribution of Pulmonary Thromboembolic Disease in Pulmonary Hypertension in Sickle Cell Disease. (2020) (2)
Hemodynamic Markers of Pulmonary Vascular Disease in Pulmonary Hypertension Due to Left Heart Disease (2015) (2)
Validation of a composite vascular high‐risk profile for adult patients with sickle cell disease (2019) (2)
Update in pulmonary vascular diseases 2012. (2013) (2)
Abstract 17003: Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure With Preserved Ejection Fraction (PH-HFpEF) (2016) (2)
Interferon-Induces p 11 Gene and Protein Expression in Human Epithelial Cells through Interferon-- activated Sequences in the p 11 Promoter * (2003) (2)
Genetic, Ethnic, and Gender Determinants of Red Blood Cell Storage and Stress Hemolysis (Meeting Abstract: S73-040A) (2015) (2)
Exercise‐induced changes of vital signs in adults with sickle cell disease (2021) (2)
Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts (2020) (2)
Plasma Level of NT-Pro-BNP In Children with Sickle Cell Disease Is Associated with Degree of Anemia and Left Ventricular Measures: The PUSH Study (2010) (2)
RATIONALE AND DESIGN OF THE PRIMEX TRIAL: A STUDY OF 2 DOSES OF ORAL CXA-10 IN PULMONARY ARTERIAL HYPERTENSION (PAH) (2020) (2)
Reduction of Nitrite to Nitric Oxide by Myoglobin Modulates Mitochondrial Respiration during Ischemia and Limits Reperfusion Injury. (2005) (2)
The Hyperhemolysis Phenotype in Sickle Cell Anemia: Increased Risk of Leg Ulcers, Priapism, Pulmonary Hypertension and Death with Decreased Risk of Vasoocclusive Events. (2006) (2)
The Effects of Inhaled Carbon Monoxide on Endotoxin-Induced Pulmonary Inflammation in Humans. (2009) (2)
Inhaled Sodium Nitrite: Results Of Multiple Ascending Dose Studies Including Pharmacodynamic Interaction With Sildenafil In Normal Healthy Volunteers (2012) (2)
The Effects of Inhaled Sodium Nitrite on Pulmonary Vascular Impedance in Patients with Pulmonary Hypertension Associated with HFpEF (2019) (2)
Modulation of cytoglobin nitrite reductase rates by distal histidine mutations (2014) (1)
PREVALENCE AND IMPACT OF PULMONARY HYPERTENSION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) LISTED FOR LUNG TRANSPLANTATION (2007) (1)
Genetic architecture of smoking: Evaluating rare variant contribution from deep whole-genome sequencing of up to 26,000 individuals (2021) (1)
Sulfite Oxidase: A Novel Nitrite Reductase that Generates Nitric Oxide (2011) (1)
Abstract 17077: Acute Hemodynamic Effects of Oral Nitrite in Pulmonary Hypertension Related to Heart Failure With Preserved Ejection Fraction (PH-HFpEF) (2018) (1)
Methodological Standards in Human vs Animal Clinical Trials—Reply (2005) (1)
Reply: Practice guideline for pulmonary hypertension in sickle cell: direct evidence needed before universal adoption. (2014) (1)
Platelet Aggregation Dysfunction in Sickle Cell Disease (2017) (1)
Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (2018) (1)
S100B has pleiotropic effects on vaso‐occlusive manifestations in sickle cell disease (2019) (1)
Genetic Polymorphisms in NEDD4L Are Associated with Pulmonary Hypertension of Sickle Cell Anemia. (2009) (1)
Impaired Bile Secretion Promotes Chronic Liver Injury in Sickle Cell Disease (2019) (1)
Nitrite therapy after cardiac arrest reduces ROS generation, improves cardiac and neurological function and enhances survival via reversible inhibition of mitochondrial complex I (2009) (1)
Cytochrome b5 Reductase T116S Mutation and Hemolysis in Sickle Cell Disease. (2009) (1)
Regulatory Genetic Variation at the S100B Gene Associates with Vaso-Occlusive Manifestations in Sickle Cell Disease (2018) (1)
Evaluation of the Functional Effects of an African American Glucose-6-Phosphate Dehydrogenase (G6PD) Polymorphism (Val68Met) on RBC Hemolytic Propensity and Post-Transfusion Recovery in a Humanized Mouse Model (2019) (1)
Nitric oxide scavenging by red cell microparticles and cell free hemoglobin as a mechanism for hemolytic diseases and the red blood cell storage lesion (2011) (1)
In vivo evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction (2023) (1)
Blood Cell Versus Vascular Endothelial Cell Contributions to Nitrite Homeostasis and Blood Pressure Regulation (2008) (1)
Detection of the mRNA Transcription Level of Several Genes of the HIF and NO Metabolic Pathways in PBMCs of Sickle Cell Disease Patients Using Quantitative RT-PCR Assay. (2007) (1)
Lung Vaso-Occlusion in Sickle Cell Disease Mediated By Arteriolar Neutrophil-Platelet Micro-Emboli (2016) (1)
Reversal of Right Ventricular Hypertrophy and Dysfunction by Prostacyclin in a Rat Model of Severe Pulmonary Arterial Hypertension (2022) (1)
A pharmacogenomic study of atorvastatin effects on eNOS activity: do "statins" modulate blood nitrite levels and intravascular oxidant stress in susceptible individuals? (2006) (1)
Exploring the Mechanism of Fast Nitrite Reduction by Five-Coordinate Neuroglobin (2011) (1)
Sex-specific genetic modifiers identified susceptibility of cold stored red blood cells to osmotic hemolysis (2022) (1)
Management of patients with sickle cell disease. (2015) (1)
Antidote for carbon monoxide poisoning (2014) (1)
Myoglobin Is a Nitrite Reductase That Generates NO and Regulates Mitochondrial Respiration. (2006) (1)
Erratum: Corrigendum: The emerging biology of the nitrite anion (2006) (1)
Endothelium Seeing Red: Should We Redefine eNOS as the Endothelial and Erythrocytic NOS? (2021) (1)
Reply: Better Studies Are Needed to Guide Treatment of Carbon Monoxide Poisoning. (2017) (1)
P2: Sodium nitrite disrupts biotic biofilm formation by Pseudomonas aeruginosa on polarized human airway epithelial cells (2013) (1)
P116. Nitrite augments post-ischemic vascular function—A putative therapeutic preconditioning mimetic (2006) (1)
Pulmonary and Critical Care Updates Update on Pulmonary Hypertension 2009 (2010) (1)
Prediction of Fetal Hemoglobin in Sickle Cell Anemia Using a Genetic Risk Score (2012) (1)
Risk Factors for Death in 632 Patients with Sickle Cell Anemia in the United States and United Kingdom (2012) (1)
Serum B12 Levels In Children with Sickle Cell Disease Are Lower Than In Healthy Control Subjects (2010) (1)
Reoxygenation/deoxygenation cycles of nitrosylhemoglobin (2002) (1)
Oral Sodium Nitrite Improves Insulin Sensitivity, Blood Pressure, and Arterial Thickening in Adults with Uncontrolled Hypertension and Metabolic Syndrome (2018) (1)
Clinical and Genetic Variability of Red Blood Cell Hemolysis in Sickle Cell Anemia (2011) (1)
Hemolysis-Associated Elevation in Tricuspid Regurgitation Velocity Predicts Reduction in Six-Minute Walk Distance After Two Years of Follow up in Children and Adolescents with Sickle Cell Disease. (2009) (1)
P74: Novel human mitochondrial enzyme can transform nitrite into nitric oxide (2013) (1)
Arginine Metabolite Profiling in Sickle Cell Disease: Abnormal Levels and Correlations with Pulmonary Hypertension, Desaturation, Hemolysis and Organ Dysfunction. (2006) (1)
Interactions of zebrafish Cytoglobins with oxygen and nitric oxide (2017) (1)
Storage additives impact stored red blood cell metabolism as much as storage time (2018) (1)
Severity of Sickle Cell Disease: Modeling Interrelationships among Hemolysis, Pulmonary Hypertension and Risk of Death. (2006) (1)
Mixed Chimerism Following Nonmyeloablative Stem Cell Transplantation for Sickle Cell Disease Prevents Intravascular Hemolysis and Restores Endothelial Function. (2004) (1)
A novel defense against hemolytic-oxidative stress (2006) (1)
Sickle Cell Mice with Hypoxia-Reoxygenation Have Oxidative and Inflammatory Liver Injury - toward a New Experimental Model for Vaso- Occlusive Injury (2008) (1)
Severe Pulmonary Arterial Hypertension Treated with ABI-009, nab-Sirolimus, an mTOR Inhibitor (2019) (1)
Unraveling the reactions of nitrite and hemoglobin in signaling, physiology and therapeutics (2007) (1)
N-Terminal Pro Brain Natriuretic Peptide In A Large Chronic Obstructive Pulmonary Disease Cohort: Clinical Characterization And Impact On Survival (2011) (1)
Vasculopathy and Pulmonary Hypertension (2014) (1)
Proteomic Identification of Dysregulated Apolipoprotein Expression in Pulmonary Hypertension Secondary to Sickle Cell Disease. (2005) (1)
Low Erythrocytic Glutathione Peroxidase-1 Activity Correlates with Hemolytic Rate in Patients with Sickle Cell Disease and Is Elevated on Hydroxyurea. (2007) (1)
Abstract P34: Nitrite Therapy upon Resuscitation from Cardiac Arrest Reversibly Inhibits Mitochondrial Complex I Reducing ROS Burst and Improving Cardiac Function and Survival (2008) (1)
Innovations in MD-only physician-scientist training: experiences from the Burroughs Wellcome Fund physician-scientist institutional award initiative. (2021) (1)
Genome Wide Association Analysis of Iron Overload in the Trans-Omics for Precision Medicine (TOPMed) Sickle Cell Disease Cohorts (2020) (1)
Metabolic syndrome contributes to the pulmonary arterial dysfunction in pulmonary hypertension in heart failure with preserved ejection fraction (2020) (1)
SGLT2 Inhibition Ameliorates Exercise-Induced Pulmonary Hypertension (EIPH) in Heart Failure with Preserved Ejection Fraction (2020) (1)
P63. Mechanisms for cellular nitrite formation: Role of ceruloplasmin and oxygen (2011) (1)
Longitudinal Change In Pulmonary Function In Children With Sickle Cell Disease And Associated Factors (2010) (1)
Non-Cardiopulmonary Factors Affecting the Six-Minute Walk Distance in Patients with Sickle Cell Disease: Results From the Walk-PHaSST Study (2011) (1)
Epidemiology and Risk Factors for Pain In Children and Adolescent with Sickle Cell Anemia. (2010) (1)
Escorting α-globin to eNOS: α-globin-stabilizing protein paves the way. (2018) (1)
Mobile Directly Observed Therapy: Monitoring and Improving Hydroxyurea Adherence in Pediatric Sickle Cell Patients (2012) (1)
Predictors of Six-Minute Walk Distance In Adults with Sickle Cell Anemia In the Walk-PHaSST Study (2010) (1)
Role of neutrophils in pulmonary vaso-occlusion during sickle cell disease acute chest syndrome (CAM3P.200) (2014) (1)
Association of G6PD −202/−376 with Lower Hemoglobin Concentration but Not Increased Hemolysis in Patients with Sickle Cell Anemia. (2009) (1)
Nitrite Attenuates Ischemia/Reperfusion (I/R) Injury of Lung by Regulating Endothelial Barrier Function (2018) (0)
Cigarette Smoking Is An Independent Predictor of Chronic Pain In Sickle Cell Patients: Results From the Walk-PHaSST Study (2010) (0)
Oxygen tension regulates H2S and NO bioavailability in reciprocal manner (885.3) (2014) (0)
HIF-Mediated and Non-HIF-Mediated Differential Gene Expressions in Sickle Cell Reticulocyte and Their Impact on Clinical Manifestations (2021) (0)
PVR BUT NOT DPG PREDICTS CARDIAC HOSPITALIZATIONS IN LEFT HEART DISEASE-ASSOCIATED PULMONARY HYPERTENSION (2016) (0)
Red blood cells express a functional endothelial nitric oxide synthase. Commentary (2006) (0)
Characterization of the Distribution of Nitrite in Human Blood. (2004) (0)
P28. Sodium nitrite enhances pulmonary epithelial cells wound healing under normoxia via cyclic GMP-independent signaling pathways (2011) (0)
Nitric Oxide Storage Lesion In Stored Blood (2010) (0)
Integrin αIIbβ3 Regulates Platelet-Procoagulant Activity in the Lung (2020) (0)
Sexual Dimorphism in Whole Blood Nitrite and Susceptibility to Hypoxic Sickle Cell Vaso-Occlusive Injury in Mice. (2005) (0)
Loss of FXR Signaling Promotes Chronic Liver Injury in Sickle Cell Disease (2020) (0)
P153 - Hemoglobin is the primary erythrocytic nitrite reductase (2014) (0)
P167. Novel function of myoglobin as a nitrite reductase modulates mitochondrial respiration (2006) (0)
Computational Modeling of Nitric Oxide Bioavailability in Hemolytic Anemias. (2006) (0)
Genetic Determinants of Hemolysis in Sickle Cell Anemia. (2012) (0)
Platelet-Neutrophil Aggregates Promote Pulmonary Arteriole Microembolism in Sickle Cell Disease (2015) (0)
P173. Nitrite mediates cytoprotection following ischemia/reperfusion injury at the mitochondrial level (2006) (0)
Abstract 463: Dietary Nitrite Plays a Role in Wound Healing in Diabetic Mice (2012) (0)
GWAS Meta-Analysis of Glomerular Filtration Rate in Three Cohorts of Sickle Cell Disease Patients and In Vivo Functional Analysis Reveals Potential Nephropathy Candidate Genes (2016) (0)
Vascular TSP1-CD47 Signaling Promotes Sickle Cell-Associated Arterial Vasculopathy 1 and Pulmonary Hypertension in Mice 2 Promotes Pulmonary Hypertension in (2019) (0)
Microparticles From Stored RBC Units Show Inflammatory Chemokine Binding That Is Altered By Platelets (2010) (0)
P204 – Carbonic anhydrase contributes to red blood cell-mediated nitrite bioactivation (2014) (0)
disease treatment to tricuspid regurgitation velocity in children with sickle cell Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea (2013) (0)
TLR4 Signaling Negatively Regulates Intestinal Microvascular Perfusion in the Pathogenesis of NEC Which Can Be Reversed With Exogenous Nitrite (2012) (0)
Electron Paramagnetic Resonance Study of Cell-Free Hemoglobin in Sickle Cell Disease: Potential Antioxidant Role of Haptoglobin. (2005) (0)
Abstract 18008: Skeletal Muscle SIRT3 is Required for Nitrite- and Metformin-Mediated Reduction of PH-HFpEF (2017) (0)
P41. Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury (2008) (0)
Nitrite, a hypoxia selective nitric oxide donor, limits renal ischemia-reperfusion injury in non-human primates (2006) (0)
Abstract 20562: Metabolic Syndrome and Pulmonary Hypertension Due to Left Heart Disease (2014) (0)
N Terminal ProBrain Natriuretic Peptide Is Associated With Low Diffusing Capacity For Carbon Monoxide In HIV Subjects (2010) (0)
PSS221 - Primary Role of Deoxygenated Hemoglobin in Erythrocytic Nitrite Reduction to NO (2013) (0)
Two Stage Intravital Imaging Mouse Model to Assess Venous Thromboembolism in Sickle Cell Disease (2021) (0)
Point of care ultrasound detection of thrombus straddling a patent foramen ovale in a patient with acute chest syndrome (2022) (0)
Abnormal Methacholine Challenge Associated With Pulmonary Arterial Hypertension In Adults With Sickle Cell Disease (2011) (0)
Endothelial NOS Uncoupling Contributes To Endothelial Permeability In Inflammatory Acute Lung Injury (2012) (0)
Mo1001 Nodular Regenerative Hyperplasia: Many Ways to Get There (2014) (0)
Acute Hemodynamic Effects of Oral Nitrite in PH-HFpEF (2019) (0)
Chronic Pain Is An Independent Predictor of Lower 6 Minute Walk Distance In Patients with Sickle Cell Disease: Results From Walk-PHaSST Study (2010) (0)
In Vivo Two-Photon Excitation Microscopy Reveals Pulmonary Arteriole Micro-Embolism in Sickle Cell Disease Mice (2014) (0)
Abstract 18666: A Carbon Monoxide (CO) Scavenging Agent Reverses CO-Induced Mitochondrial Inhibition in vitro and in vivo (2016) (0)
Categorization And Functional Impact Of Pulmonary Hypertension In Patients With COPD (2010) (0)
Targeted Proteomics of Pulmonary Hypertension in Sickle Cell Disease (2021) (0)
P172 – Direct soluble guanylate cyclase activation improves vascular function in a mouse model of sickle cell disease (2014) (0)
P25. Deoxygenated non-symbiotic plant hemoglobins function as nitrite reductases (2011) (0)
P47: AMPK activation by nitrite and metformin increases glut-4 mediated glucose uptake and normalizes pulmonary venous hypertension in a rat model of severe metabolic syndrome (2013) (0)
P69. Effect of sodium nitrite on bleomycin-induced lung injury and ‘fibrosis in mice (2011) (0)
Iron-Mediated Free Radical Formation by Aged PRBC Units: Implications for Clinical Transfusion (2010) (0)
Flipping Off and On the Redox Switch in the Microcirculation. (2023) (0)
Exercise Induced Changes of Vital Signs in Adults with Sickle Cell Disease (2020) (0)
Recombinant Neuroglobin Reverses the Molecular Mitochondrial Effects of Carbon Monoxide Poisoning Through Carbon Monoxide Scavenging (2019) (0)
Smokers With Carotid Atherosclerosis Have Evidence Of Endothelial Dysfunction (2012) (0)
Genetic , ethnic and sex determinants of red blood cell storage and stress hemolysis (2016) (0)
Sec14l4 SNP Mice Have Increased Susceptibility to Oxidative Hemolysis through Modulation of G6PD and the Pentose Phosphate Pathway (2022) (0)
Immune exhaustion is associated with development of cardiopulmonary disease in a non-human primate model of HIV-infection (HUM8P.340) (2014) (0)
Treatment with Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pre-Clinical Model of Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction (PH-HFpEF) (2019) (0)
Dynamic hyperinflation and intrinsic positive end-expiratory pressure (2013) (0)
Differentiating the Molecular Signature and Clinical Course of E-Cigarette, or Vaping, Product Use Associated Lung Injury (EVALI) Versus Other Forms of Lung Injury (2020) (0)
Lower Ferritin Concentrations in Children with Sickle Cell Disease Are Associated with Decreased Hemolysis and Lower Tricuspid Regurgitant Velocity (2008) (0)
A Novel Allogeneic Transplant Conditioning Regimen Designed for Tolerance Induction in Patients with Severe Sickle Cell Disease. (2005) (0)
Platelets from Patients with Sickle Cell Disease and Pulmonary Arterial Hypertension Are Hypersensitive to Agonist-Induced Activation. (2006) (0)
Hemoglobinuria Is a Risk Factor For Kidney Disease Progression In Sickle Cell Anemia (2013) (0)
RIGHT VENTRICULAR STRAIN ANALYSIS IN A LARGE COHORT OF PATIENTS WITH SICKLE CELL DISEASE (2022) (0)
403The Role of Free Radicals in Hemolysis Associated Platelet Activation (2012) (0)
Evaluation of the Functional Effects of a SEC14 Like Lipid Binding 4 (SEL14L4) SNP on Red Blood Cell Hemolytic Propensity in a Murine Model (0)
P206 – Evaluation of putative nitrite anhydrase activity of carbonic anhydrase (2014) (0)
66. Nitrite Protects Rat Lung Grafts Against Ischemia Reperfusion Injury (2008) (0)
Abstract 14297: Potential Role of the Tumor Suppressor WWOX in Mediating Skeletal Muscle-Lung Vasculature Crosstalk in PH-HFpEF (2020) (0)
Explore the Mechanisms for the Development of Post-Splenectomy Pulmonary Hypertension in a Mouse Model of β-Thalassemia (2019) (0)
Effect of Red Blood Cells Containing S-Nitrosated Hemoglobin on Hypoxic Pulmonary Vasoconstriction: [2002][A-1302] (2002) (0)
1172-74 Pulmonary hypertension is strongly associated with mortality in sickle cell disease: Comparison of echocardiographic outcome predictors (2004) (0)
Abstract 107: Cytochrome B5 Reductase 3 Sensitizes Soluble Guanylate Cyclase to Nitric Oxide in Vascular Smooth Muscle (2015) (0)
P1 - TRANSLATING REDOX BIOLOGY TO MEDICINE: THE ANION NITRITE AS ANINTRINSIC HYPOXIC SIGNALING MOLECULE AND NEW THERAPY FORPULMONARY ARTERIAL HYPERTENSION (2014) (0)
Acute and chronic lung infections. Novel pathogens, diagnostics, and therapeutics. (2014) (0)
Mouse Pneumonia Model of Sickle Cell Acute Chest Syndrome. (2004) (0)
Role of neutrophils in pulmonary vaso‐occlusion during sickle cell disease acute chest syndrome (669.6) (2014) (0)
PULMONARY, SLEEP, AND CRITICAL CARE UPDATE Update in Pulmonary Vascular Diseases and Right Ventricular Dysfunction 2019 (2020) (0)
Phosphodiesterase Inhibition Increases Fetal Hemoglobin in Sickle Cell Disease; L-Arginine Supplementation Does Not. (2007) (0)
Stop Light: Mortality Risk In Adult Sickle Cell Disease and Criteria For Hematopoietic Stem Cell Transplant (2013) (0)
Running head: Hemolysis-associated platelet activation (2013) (0)
Mechanism of Pulmonary Thrombosis in Hemolytic Disorders (2019) (0)
Reduced nitric oxide bioavailability contributes to endothelial dysfunction in a murine model of β-thalassemia (2014) (0)
675: Phosphodiesterase Type 5 Inhibitor Therapy Corrects “Nitric Oxide” Imbalance in Sickle Cell Anemia-Associated Priapism (2007) (0)
and Innate Variation in Nitric Oxide Production by Mononuclear Cells Variation in the Pulmonary Hypertensive Responsiveness of Broilers to Lipopolysaccharide (2015) (0)
Correction for Deleault et al., Formation of native prions from minimal components in vitro (2008) (0)
Longitudinal changes in age and race of patients with SARS-CoV-2 in a multi-hospital health system (2021) (0)
NT-Probnp as a Marker of Cardiopulmonary Compromise and Exercise Limitation In Adults with Sickle Cell Anemia In the Walk-PHaSST Study (2010) (0)
European Ancestry Is Associated with Acute Chest Syndrome in Sickle Cell Disease (2014) (0)
Genome‐wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci (2023) (0)
Pulmonary Hypertension In The Medical Intensive Care Unit Population: Retrospective Investigation Of Risk Factors And Impact On Survival (2010) (0)
Hemoglobin α in Pulmonary Endothelium: Ironing Out Nitric Oxide Signaling. (2017) (0)
CYTOPROTECTIVE EFFECTS OF NITRITE DURING ISCHEMIA-REPERFUSION OF THE LIVER: 254 (2004) (0)
The Reductive Nitrosylation of Hemoglobin: Low Nitric Oxide Effects and Mechanisms for N2O3 Formation (2010) (0)
Sodium nitrosoprusside protects against oxygen cycling-induced reduction in deformability of sickle red blood cells (2014) (0)
Nitrite improves Zebrafish Cardiac Regeneration Potentially by Cytoglobin 1 (2017) (0)
Abstract 17937: Effect of Remodulin in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction (PH-HFpEF) (2017) (0)
Response to Letter Regarding Article, “Nitrite Anion Provides Potent Cytoprotective and Antiapoptotic Effects as Adjunctive Therapy to Reperfusion for Acute Myocardial Infarction” (2009) (0)
Nitric Oxide-Dependent Blood Flow in Patients with Sickle Cell Disease Is Reflected by the Reactive Hyperemia-Peripheral Arterial Tonometry Index (2008) (0)
Abstract 14758: Explore the Mechanisms for the Development of Post-Splenectomy Cardiovascular Complications in a Thalassemic Murine Model (2018) (0)
Applying A New Technique For Collecting Mature Human Vascular Endothelial Cells In Patients With Lung Disease (2012) (0)
Efficient Reduction of Human Cytoglobin and Neuroglobin by the NADH/cytochrome b5 Reductase 4 Reducing System (2020) (0)
Pulmonary Hypertension in Adults and Children with Sickle Cell Disease in Nigeria: Prevalence, Clinical Characteristics and Role of Endemic Tropical Infections. (2007) (0)
Red blood Cell eNOS Does Not Modulate Hemolytic Response To Various Stressors Or Prolonged Hypothermic Storage (2011) (0)
Evaluation of the Effect of the African Glucose-6-Phosphate Dehydrogenase (G6PD) Polymorphism (Val68Met) on the Acute Inflammatory Response to Endotoxemia in a Humanized Murine Model (2020) (0)
S of a Feather Flock Together ? How an Inflammation-Driven Epigenetic Regulator May Link Pulmonary Hypertension and Coronary Artery Disease (2017) (0)
TSP1-CD47 Signaling Modulates the Severity of Pulmonary Hypertension in a Mouse Model of Sickle Cell Disease (2011) (0)
Left Ventricular Ejection Fraction Cut Point of 50% for Heart Failure With Preserved Ejection Fraction-Reply. (2018) (0)
Purification and Characterization of Zebrafish (Danio Rerio) Globin X (2011) (0)
PULMONARY, SLEEP, AND CRITICAL CARE UPDATE Update in Pulmonary Vascular Diseases 2014 (2015) (0)
The Global Perspective Disorders : Pulmonary Vascular Disease: Pulmonary Hypertension in Hemolytic (2010) (0)
A 53-Year-Old Woman with Severe Carbon Monoxide Poisoning. (2017) (0)
288: GENERATION OF CELL-FREE HEMOGLOBIN (FHB) AND CONSUMPTION OF NITRIC OXIDE (NO) IN INFANTS AND CHILDREN UNDERGOING CARDIOPULMONARY BYPASS (CPB) (2012) (0)
Hematocrit and Oxygen Dependence of Nitric Oxide Scavenging by Red Blood Cells. (2005) (0)
P41. Sulfite oxidase: A novel nitrite reductase that generates nitric oxide (2011) (0)
Measurement and Simulation of Nitric Oxide Uptake by Hemoglobin-Containing Vesicles and Red Blood Cells (2011) (0)
94 – Pulmonary Complications of Hematologic Diseases (2016) (0)
AMP Kinase Activation Attenuates Cardiac Remodeling in Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction; Lung Epithelial Progenitor Cells in Alveolar Regeneration; and Drug Discovery and Novel Therapies for Lung Cancer. (2019) (0)
The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations (2022) (0)
Imaging Echocardiographic Markers of Elevated Pulmonary Pressure and Left Ventricular Diastolic Dysfunction Are Associated With Exercise Intolerance in Adults and Adolescents With Homozygous Sickle Cell Anemia in the United States and United Kingdom (2011) (0)
Myosin Light Chain Kinase Genetic Variation and the Risk of Precapillary Pulmonary Hypertension in Sickle Cell Disease (2019) (0)
Sex-specific genetic modifiers identified susceptibility of cold stored red blood cells to osmotic hemolysis (2022) (0)
An Elevated Tricuspid Regurgitant Jet Velocity In Sickle Cell Disease Is Associated With Polymorphisms In Genes Impacting Innate Immunity (2011) (0)
ECHOCARDIOGRAPHIC PREDICTORS OF DECLINING EXERCISE PERFORMANCE IN CHILDREN WITH SICKLE CELL DISEASE (2010) (0)
172 - Antidote for Carbon Monoxide Poisoning (2014) (0)
Neutrophil-Platelet Micro-Emboli Enable Vaso-Occlusion in Sickle Cell Disease (2014) (0)
Abstract 10677: Skeletal Muscle Sirt3 Deficiency-Mediated Loxl2 Secretion in Remote Pulmonary Vascular Remodeling and Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction (2021) (0)
Hemolytic-Anemia-Associated Pulmonary Hypertension: Sickle-Cell-Disease- and Thalassemia-Associated Pulmonary Hypertension (2011) (0)
Kinetics of Nitric Oxide reactivity with Micro Vesicle-Encapsulated Hemoglobin (2010) (0)
Generation of superoxide radical by human cytochrome b5 reductase is modulated by cytochrome b5 (2018) (0)
Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients, as a function of therapeutic transfusion and hydroxyurea treatment (2023) (0)
Endothelial Biomedicine: Cross-Talk between the Red Blood Cell and the Endothelium: Nitric Oxide as a Paracrine and Endocrine Regulator of Vascular Tone (2007) (0)
Hospitalization for Acute Pain in Sickle Cell Disease: Changes in Clinical Parameters and Factors Predicting Hospital Discharge and Re-Admission (2016) (0)
Safety of liver biopsy in patients with sickle cell related liver disease: A single‐center experience (2022) (0)
In vivo evaluation of the effect of sickle cell hemoglobin S, C and therapeutic transfusion on erythrocyte metabolism and cardiorenal dysfunction. (2023) (0)
Oxidant, Hemolytic and Inflammatory Stress of Sickle Cell Disease Blood Mononuclear Cell Gene Expression Profiles Characterize the (2004) (0)
Superior Targeted Anti-Platelet Activity of Nitrite (2016) (0)
Optimizing interpretation of survival studies of fresh and aged transfused biotin‐labeled RBCs (2022) (0)
QS3. Low Dose Nebulized Nitrite Prevents or Reverses Pulmonary Hypertension and Is Dependent on Xanthine Oxidoreductase (2008) (0)
Potential of Angeli’s Salt To Reduce Nitric Oxide Scavenging in Hemolysis. (2007) (0)
Oral 1822-1 - Nitrite and nitrate-dependent generation of fatty acid nitroalkenes (2014) (0)
Nitrite Alters Alveolar Macrophage Activation In The Inflammatory Response To Acute Lung Injury (2011) (0)
Amplified Expression Profiling of Platelet Transcriptome Reveals Global Activation of Arginine Metabolic Pathways in Patients with Sickle Cell Disease. (2006) (0)
Oxygen Desaturation at Rest and after Exercise in Pediatric Sickle Cell Disease Patients: Correlations with Hemolysis and Elevated Tricuspid Regurgitant Jet Velocity. (2008) (0)
Association of Genetic Variation in the Catechol-O-Methyl Transferase Gene with Pain and Six Minute Walk Distance in Sickle Cell Anemia Patients From the Walk-PHaSST Study (2011) (0)
PP53 - Nitrite administration ameliorates mitochondrial bioenergetics and is neuroprotective in cellular and vertebrate models of Parkinson’s disease (2013) (0)
Abstract 20681: Drug Discovery for PH-HFpEF: High Throughput Screening in Identification of SIRT3 Activators (2017) (0)
Nitrite modulation of cardiac contractility in vertebrate hearts (2008) (0)
P148 - Chronic oral nitrite therapy improves hyperglycemia and normalizes pulmonary venous hypertension through a mechanism involving the activation of Sirt3 and AMPK (2014) (0)
First report of 68Ga-PRGD2 PET/MRI molecular imaging of vaso-occlusion in a patient with sickle cell disease (2020) (0)
Innate Immune Mechanism of Hemarthrosis in Hemophilia-a Mice (2019) (0)
Amending NIH Consensus Criteria for the Clinical Diagnosis of Bronchiolitis Obliterans After HSCT (2009) (0)
Cell-free and alkylated hemoproteins improve survival in mouse models of carbon monoxide poisoning (2022) (0)
Exploration of inflammatory biomarkers in three depots of adipose tissue in women with endometrial cancer 2 (2017) (0)
Recent Insights into the Biological Signaling Properties of Sodium Nitrite (2010) (0)
Urine and Plasma Nitrate After Oral Nitrate Administration in Patients with PH-HFpEF Compared to Healthy Controls (2019) (0)
impairment in nitric oxide bioavailability Hemolysis in sickle cell mice causes pulmonary hypertension due to global (2012) (0)
Soluble Guanylate Cyclase Modulators Effect Fetal Hemoglobin Levels through a Non-cGMP-Protein Kinase G Signaling Pathway (2018) (0)
330 - Reduction of Hexacoordinate Globins by Cytochrome B5 (2014) (0)
Hemolysis-Endothelial Dysfunction Syndrome: A Novel Paradigm of Disease Mechanism. (2004) (0)
Abstract 2303: Prospective Correlation of Echocardiography Findings with Hematologic and Pulmonary Function Parameters in Children with Sickle Cell Disease (2007) (0)
Improvement in Hemolytic Parameters and Tricuspid Regurgitant Jet Velocity (TRV) Following Non-Myeloablative Allogeneic Stem Cell Transplantation (allo-SCT) in Adults with Severe Sickle Cell Disease (SCD). (2007) (0)
Sickle Cell Disease Promotes Dysregulation of Hepatic Iron Homeostasis By Regulating Hepcidin Expression (2019) (0)
317: FREE HEMOGLOBIN GENERATED BY PEDIATRIC CARDIOPULMONARY BYPASS IS ASSOCIATED WITH ORGAN DYSFUNCTION (2013) (0)
Cell-Free Hemoglobin, HMOX1 and APOL1 in Sickle Cell Nephropathy (2014) (0)
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency of the African American Variant (Val68Met) Protects Against Klebsiella Pneumoniae Intrapulmonary Infection in Mice (2021) (0)
Association of Hemolysis with Clinical Manifestations of Sickle Cell Disease (2008) (0)
Harnessing the Nitrate-Nitrite-NO Pathway for Therapy of Heart Failure with Preserved Ejection Fraction Running title: Vanderpool et al.; Harnessing the nitrate-nitrite-NO pathway (2014) (0)
Abstract P726: Cytochrome B5 Reductase 3 Modifies The Brain-Blood Axis Response To Ischemic Stroke In Mice With Sickle Cell Disease (2021) (0)
PVR Predicts Cardiac Hospitalizations in Pulmonary Hypertension Associated with HFpEF and HFrEF (2016) (0)
Reversal of Right Ventricular Hypertrophy and Dysfunction by Remodulin in a Rat Model of Severe Angioproliferative Pulmonary Arterial Hypertension (2015) (0)
1 - The Effects of Nitrogen Oxides and Sulfides on Gardos Channel Activity and Red Blood Cell (RBC) Deformability (2014) (0)
P25: Effect of distal heme pocket mutations on neuroglobin nitrite reduction rates (2013) (0)
Heme Coordination and Nitrite Reductase Activity of Human Neuroglobin (2010) (0)
Sodium Nitrite Enhances Lung Airway Epithelial Cells Wound Healing In Vitro And Alleviates LPS-induced Acute Lung Injury In Mice (2010) (0)
Nitrite Administration Increases Insulin Sensitivity And Lowers Blood Pressure In Genetically Obese Mice (2011) (0)
Abstract 18112: SIRT3-AMPK Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes PH-HFpEF (2014) (0)
Regulation of Physiological In Vivo Vasodilation Under Hypoxia Depends on Reduction of Endogenous Nitrite via Myoglobin (2012) (0)
Study Of Clinical Characteristics Of Sickle Cell Disease Patients Developing Cor-Pulmonale During Acute Hospitalization (2011) (0)
Hiv Nef Induces Pulmonary Artery Smooth Muscle Cell Hyperplasia (2011) (0)
Abstract 595: Functional, Histologic, and Radiographic Characteristics of Global Ischemia-reperfusion Brain Injury in a Mouse Model Of Cardiac Arrest (2008) (0)
Inhaled Sodium Nitrite Is an NO Prodrug and Vasodilator. (2009) (0)
Manuscript no. HAEMATOL/2011/051839 entitled "Pulmonary artery pressure and iron deficiency in patients with up-regulation of hypoxia sensing due to homozygous VHLR200W mutation (Chuvash polycythemia)" (2011) (0)
viscosity on hypoxic pulmonary vasoconstriction Effects of the RBC membrane and increased perfusate (2015) (0)
Dietary nitrate and cardiovascular health (2014) (0)
Abstract 17004: Five-coordinate H64Q Neuroglobin as a Ligand-trap Antidote for Carbon Monoxide Poisoning (2016) (0)
O36. Human neuroglobin functions as an allosteric nitrite reductase in hypoxia (2008) (0)
Cell-Free Hemoglobin Challenge Worsens Lung Injury in Experimental Canine Staphylococcus Aureus Pneumonia Inducing Septic Shock (2020) (0)
Exercise Capacity and Hemodynamics in Sickle Cell Disease with Pulmonary Hypertension. (2009) (0)
Platelet Activation Is Linked to the Severity of Pulmonary Hypertension in Sickle Cell Disease and Normalizes on Sildenafil Therapy. (2005) (0)
Selection of the optimal nebulizer for further clinical development of inhaled nebulized nitrite (AIR001) in pulmonary arterial hypertension patients (2012) (0)
Use of nitrite salt for the treatment of cardiovascular diseases (2004) (0)
Abstract 324: An Engineered Protein as an Antidote for Carbon Monoxide Poisoning That Can Reverse Cardiovascular Collapse Through Scavenging of Carbon Monoxide and Rescue of Mitochondrial Respiration (2018) (0)
Genome-wide meta-analysis identifies new candidate genes for sickle cell disease nephropathy. (2022) (0)
Lower Ferritin Concentrations Are Associated with Decreased Hemolysis in Sickle Cell Disease Children without Iron Overload. (2009) (0)
P47. Anesthetic modulation of physiological nitric oxide species (2008) (0)
High Carbon Monoxide-Affinity Hemoproteins Reverse the Effects of Moderate to Severe Carbon Monoxide Poisoning (2020) (0)
Prospective Evaluation of the Prevalence of Elevated Tricuspid Regurgitant Jet Velocity and Associated Clinical and Echocardiographic Factors in Children and Adolescents with Sickle Cell Disease. (2007) (0)
CD39 as a Master Regulator of Pulmonary Thrombosis in Sickle Cell Disease (2019) (0)
Correlations Between Cytokines and Elevated Tricuspid Regurgitant Jet Velocity in Children and Adolescents with Sickle Cell Disease (2008) (0)
A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease. (2016) (0)
P165. Ceruloplasmin is an NO oxidase that regulates nitrite homeostasis (2006) (0)
Abstract 12361: Cytoglobin Regulates Cilia Length, Function and Organ System Laterality During Development (2019) (0)
Characterization of Microrna Expression Profile In Platelets In Sickle Cell Disease (2010) (0)
Cover Picture: Hemoglobin as a Nitrite Anhydrase: Modeling Methemoglobin‐Mediated N2O3 Formation (Chem. Eur. J. 23/2011) (2011) (0)
Risk Factors for Kidney Disease in Hb SC and Hb Sβ+-Thalassemia Sickle Cell Disease (2019) (0)
Hemolysis-associated priapism in sickle cell disease. Commentary (2005) (0)
Abstract 22: Systemic Nitrite (NO2-) Levels are Depleted in a Mouse Model of Asystolic Cardiac Arrest and Therapeutic Repletion Improves Survival and Functional Neurological Recovery (2007) (0)
Direct soluble guanylate cyclase activation improves vascular function in a mouse model of sickle cell disease (2014) (0)
Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease (2015) (0)
Thiol catalyzed formation of NO-ferroheme regulates canonical intravascular NO signaling (2023) (0)
Nitrite is a vascular store of NO which mediates hypoxic signaling and protects against ischemia/reperfusion injury (2007) (0)
Plasma Thrombospondin 1 Is Increased and Associated with Markers of Vasculopathy In Sickle Cell Disease (2010) (0)
Repetitive Hemolysis Induces Severe Angioproliferative Pulmonary Hypertension In Rats (2012) (0)
ESTIMATING THE PREVALENCE OF PULMONARY HYPERTENSION DUE TO LEFT HEART DISEASE IN PATIENTS UNDERGOING A RIGHT HEART CATHETERIZATION (2015) (0)
Oxygen Inhibits Nitrite Reduction to Nitric Oxide by the Molybdenum-Dependent mARC-2 Enzyme (2017) (0)
(1161) - Nitrite Improves Mitochondrial Dysfunction Induced by Hypoxia/Reoxygenation in Lung Epithelial Cells: Implications for Ischemia-Reperfusion (I/R) Injury in Lung Transplantation (2017) (0)
Nitric Oxide and its InteractionsPSS222 - Mechanism of Faster NO Scavenging by Older Stored Red Blood Cells (2013) (0)
P168 - The donor effect of sickle cell trait on host NO bioavailability following red blood cell transfusion (2014) (0)
Hydroxyurea Treatment Is Associated with Elevated Serum Erythropoietin Concentration but Suppressed Global Hypoxic Transcriptional Responses in Sickle Cell Disease (2015) (0)
S-Nitrosation of Hemoglobin and Hypoxic Pulmonary Vasoconstriction (2001) (0)
PULMONARY HYPERTENSION IN PATIENTS WITH BRONCHIOLITIS OBLITERANS POST-LUNG TRANSPLANTATION (2007) (0)
Role of Trace Metal Ions in Ascorbate-Mediated Reduction of S-Nitrosothiols (2010) (0)
Depletion and Restoration of the Intravascular Nitrite (NO2-) Reserve Modulate Susceptibility to Liver Vaso-Occlusive Infarction in Sickle Cell Transgenic Mice. (2007) (0)
Mixed Hematopoietic Chimerism for Sickle Cell Disease Prevents Intravascular Hemolysis and Corrects Biomarkers of Endothelial Function. (2005) (0)
Sickle-cell disease 3 Cardiovascular complications and risk of death in sickle-cell disease (2016) (0)
Sickle-cell disease 3 Cardiovascular complications and risk of death in sickle-cell disease (2016) (0)
Early Predictors of Fetal Hemoglobin Response to Hydroxyurea in Sickle Cell Disease. (2005) (0)
Searching for a Novel Pharmacologic Treatment for PH-HFpEF: From HTS to Animal Models (2019) (0)
P27. Effects of nitrite in an obese and pulmonary hypertensive rat model (2011) (0)
Clinical and Laboratory Predictors of 30-Day Hospital Readmission Risk in Adult Patients with Sickle Cell Disease (2018) (0)
Inhaled nitrite treats experimental pulmonary arterial hypertension (2006) (0)
Circulating Neutrophil Extracellular Traps in the Pathogenesis of Acute Chest Syndrome of Sickle Cell Disease (2019) (0)
Interrogating the cytoglobin binding pocket and thiol redox status with point mutations and chemical probes (2018) (0)
Sodium Nitrite Increases Regional Blood Flow in Patients with Sickle Cell Disease. (2005) (0)
Erythroid Microparticles From Stored RBC Units Elicit TNF-A Response In Macrophages (2011) (0)
Figure. Kaplan-Meier Estimates of Survival for Patients With Sickle Cell Disease by Pulmonary Hypertension Status (2013) (0)
Sickle Cell Disease and Pulmonary Hypertension: Addressing the Mixed Pathology and Special Considerations in Diagnosis and Treatment (2007) (0)
Genetic Modifiers Identify a High Risk Group for Stroke in Three Independent Cohorts of Sickle Cell Anemia Patients (2016) (0)
Genetic regulation of fetal hemoglobin across global populations (2023) (0)
Severe Pulmonary Hypertension in Sickle Cell Patients with HIV Infection. (2004) (0)
Pulmonary Function Tests and Their Correlation with Tricuspid Regurgitant Jet Velocity in Pediatric Sickle Cell Disease Patients. (2007) (0)
Rituximab and Omalizumab in Severe, Refractory Insulin Allergy (2009) (0)
Pulmonary Function in Children with Sickle Cell Disease and Its Association with Markers of Inflammation. (2009) (0)
Association of Genetic Polymorphisms In NEDD4L With Pulmonary Hypertension Of Sickle Cell Disease (2010) (0)
Mechanistic Study of Hemoglobin Induced Platelet Activation (2011) (0)
P52. Dietary nitrate and nitrite modulate the cellular response to ischemic stress (2008) (0)
Abstract 16734: Oral Nitrite Supplementation Improves Skeletal Muscle Mitochondrial Respiration and Cardiorespiratory Fitness in Older Adults With Heart Failure With Preserved Ejection Fraction (2020) (0)
Sodium Nitrite Enhances Pulmonary Epithelial Cells Wound Healing Under Normoxia via Cyclic GMPindependent Signaling Pathways (2010) (0)
The T117S Variant of Cytochrome b5 Reductase 3 Increases the Risk for Ischemic Stroke with Enhanced Anemia in Mice with Sickle Cell Disease (2020) (0)
Formation of Nitroso Compounds in the Reaction of Nitrite and Hemoglobin. (2006) (0)
Abstract 17907: Clinical Outcomes and Mortality Impact of Hyperbaric Oxygen Therapy in Patients With Carbon Monoxide Poisoning (2017) (0)
Loss of Cyb5R3 Function Silences Fetal Hemoglobin and Hematocrit Responses to Hydroxyurea in Patients with Sickle Cell Anemia (2022) (0)
Reply to Sakai: What Is the Major Mechanism of Slower NO Uptake by Red Blood Cells (2011) (0)
How do red blood cells dilate blood vessels?--Reply. (2004) (0)
32: Nitrite Protects Rat Lung Grafts from Ischemia/Reperfusion Injury Via Xanthine Oxidoreductase (XOR) (2008) (0)
Abstract 3636: The Effects of Arginase II Overexpression on Endothelial Function in Transgenic Mouse Model (2008) (0)
O34. Nitrite mediates cytoprotection after ischemia/reperfusion through the modulation of mitochondrial function (2008) (0)
Abstract 15694: Roles of Nitrite and Metformin in Severe Pulmonary Arterial Hypertension (PAH) and Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction (PH-HFpEF) (2015) (0)
Plasma NTPDase1 Activity Regulates Platelet Purinergic Signaling in Sickle Cell Disease (2021) (0)
Liver Hypoxia and Tissue Injury Are Specific to Sickle Cell Mice in An Experimental Model of Sickle Cell Vaso-Occlusion. (2009) (0)
P112 - Reduction of nitrite to NO by zebrafish (Danio rerio) six-coordinate heme globins (2014) (0)
15 - Carbonic Anhydrase Mediated Nitrite Bioactivation (2014) (0)
Oral 2021-1 – Intramolecular electron transfer controls nitrite reduction in molybdenum-containing sulfite oxidase (2014) (0)
Abstract 20581: Population Based Characterization of the Definition, Prevalence and Associated Mortality of Pulmonary Hypertension in the Setting of Left Heart Disease (2016) (0)
Is Nitrite Cardioprotective In An Obese And Pulmonary Hypertensive Rat Model (2012) (0)
Phenotypic and Genetic Discordance in Monozygotic Twins with Sickle Anemia and ð-Thalassemia. (2009) (0)
Evaluation of Exercise Capacity In Children with SCD by Six Minute Walk Test (2010) (0)
Platelet αIIbβ3 Promotes Acute Pulmonary Thromboembolism (2019) (0)
Novel Rodent Model of Exercise-Induced Pulmonary Hypertension (EIPH) in Heart Failure with Preserved Ejection Fraction (2019) (0)
Admixture In Sickle Cell Disease Defined By Genome Wide Ancestry Informative Markers Varies By Geographic Region In The United States (2013) (0)
206 – Novel Small Molecule Inhibitors of Cytochrome B5 Reductase 3 Were Identified by Structure Guided Chemical Modifications of Propylthiouracil (2014) (0)
P42: Nitrite exposure under hypoxia improve heart regeneration in zebrafish (2013) (0)
171: Nebulized Nitrite Protects Rat Lung Grafts from Ischemia/Reperfusion Injury (2010) (0)
Impaired Hepcidin Metabolism Promotes Hemolysis Induced Hepatobiliary Injury in Sickle Cell Disease (2020) (0)
Chapter 11 – The Reaction between Nitrite and Hemoglobin: The Role of Nitrite in Hemoglobin-mediated Hypoxic Vasodilation (2008) (0)
P70. Nitrite protects rat lung grafts from cold ischemia-reperfusion injury (2011) (0)
9: RENAL INJURY ASSOCIATED WITH FREE HEMOGLOBIN IN RAT CARDIOPULMONARY BYPASS IS ATTENUATED BY NITRITE (2015) (0)
Sec14-like-Lipid-Binding-4 Enables Hemoglobin Clearance By Liver Sinusoidal Endothelial Cells (2022) (0)
Changes in the Distal Heme Pocket of Neuroglobin Modulate Autoxidation Rates (2012) (0)
Reply: Carbon Monoxide Exposure in Workplaces, Including Coffee Processing Facilities. (2017) (0)
Mutations and Polymorphisms Influencing Hemolysis in Hemoglobin Genes and Risk of Pulmonary Hypertension in Sickle Cell Disease: Effect of Hemoglobin SC. (2006) (0)
Spontaneous Pulmonary Hypertension in Transgenic Sickle Cell Mice - Hemodynamics and Histology Suggest Abnormal Nitric Oxide Production and Scavenging. (2005) (0)
Evidence for S-nitrosothiol Formation by a Nitrite Dependent Pathway During Reductive Nitrosylation of Ferric Hemoglobin (2010) (0)

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University of Liverpool
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