Markku Laakso

Q: What Schools Are Affiliated With Markku Laakso

Markku Laakso is affiliated with the following schools: Indiana University Bloomington, Indiana University, University of Eastern Finland, University of California, San Diego, Helsinki University of Technology, University of California, Los Angeles, Aalto University, University of Turku, University of Oulu, King's College, Aberdeen, University of Helsinki

Markku Laakso's AcademicInfluence.com Rankings

Markku Laakso

Philosophy

#2068

World Rank

#3610

Historical Rank

Logic

#421

World Rank

#802

Historical Rank

philosophy Degrees

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Philosophy

Markku Laakso's Degrees

Doctorate Medicine University of Helsinki
PhD Medical Sciences University of Helsinki

Why Is Markku Laakso Influential?

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According to Wikipedia, Markku Laakso is a Finnish professor of medicine and a type 2 diabetes researcher. He was awarded the Matti Äyräpää Prize in 2007, the Kelly West Award in 2008, and the Finnish Science Award in 2015.

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Markku Laakso's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. (2001) (10208)
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial (2005) (3960)
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α (2006) (3817)
Genetic studies of body mass index yield new insights for obesity biology (2015) (3549)
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. (1998) (3318)
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial (2005) (2839)
“Effective” Number of Parties (1979) (2614)
Discovery and Refinement of Loci Associated with Lipid Levels (2013) (2475)
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial (2002) (2389)
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (2010) (2087)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index (2010) (2011)
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk (2011) (1928)
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes (2008) (1882)
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes (2012) (1839)
Defining the role of common variation in the genomic and biological architecture of adult human height (2014) (1805)
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (2010) (1801)
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). (2006) (1767)
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation (2009) (1735)
Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial (2006) (1681)
Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. (2003) (1655)
Large-scale association analysis identifies new risk loci for coronary artery disease (2012) (1507)
A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity (1998) (1401)
Common variants at 30 loci contribute to polygenic dyslipidemia (2009) (1380)
Integrative approaches for large-scale transcriptome-wide association studies (2015) (1235)
New genetic loci link adipose and insulin biology to body fat distribution (2014) (1227)
Genome-wide association study identifies eight loci associated with blood pressure (2009) (1225)
Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index (2010) (1179)
Diabetes and atherosclerosis: an epidemiologic view. (1987) (1036)
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps (2018) (1028)
Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. (1990) (1015)
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility (2014) (933)
The genetic architecture of type 2 diabetes (2016) (927)
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use (2018) (914)
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (2010) (897)
How good a marker is insulin level for insulin resistance? (1993) (804)
Common variants associated with plasma triglycerides and risk for coronary artery disease (2013) (767)
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways (2012) (758)
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance (2012) (756)
Hyperglycemia and cardiovascular disease in type 2 diabetes. (1999) (756)
Variants in MTNR1B influence fasting glucose levels (2009) (742)
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries (2018) (735)
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion (2009) (698)
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. (2011) (671)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (659)
NIDDM and Its Metabolic Control Predict Coronary Heart Disease in Elderly Subjects (1994) (655)
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. (2013) (650)
Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. (2005) (647)
Effect of valsartan on the incidence of diabetes and cardiovascular events. (2010) (626)
Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. (2005) (625)
The European Stroke Prevention Study (1991) (569)
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture (2013) (568)
Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus. (1996) (553)
Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity (2005) (544)
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2015) (532)
Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution (2009) (516)
Safety and Feasibility of Catheter-Based Local Intracoronary Vascular Endothelial Growth Factor Gene Transfer in the Prevention of Postangioplasty and In-Stent Restenosis and in the Treatment of Chronic Myocardial Ischemia: Phase II Results of the Kuopio Angiogenesis Trial (KAT) (2003) (516)
Rare and low-frequency coding variants alter human adult height (2016) (511)
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children (2011) (508)
Impaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM (1992) (492)
Type 2 (467)
Type 2 diabetes as a "coronary heart disease equivalent": an 18-year prospective population-based study in Finnish subjects. (2005) (447)
Effect of nateglinide on the incidence of diabetes and cardiovascular events. (2010) (440)
Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study (1997) (439)
Exome-wide association study of plasma lipids in >300,000 individuals (2017) (428)
Insulin resistance and hyperglycaemia in cardiovascular disease development (2014) (425)
Dyslipidemia and Hyperglycemia Predict Coronary Heart Disease Events in Middle-Aged Patients With NIDDM (1997) (421)
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico (2013) (419)
Gender difference in the impact of type 2 diabetes on coronary heart disease risk. (2004) (410)
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes (2014) (405)
Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. (1998) (405)
A structural variation reference for medical and population genetics (2020) (394)
The DELPHI detector at LEP. (1991) (393)
Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma (1992) (393)
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function (2016) (388)
Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland Study design and 1-year interim report on the feasibility of the lifestyle intervention programme (1999) (386)
Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. (1998) (367)
Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. (2000) (365)
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits (2013) (365)
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1) (2004) (353)
Quantifying prion disease penetrance using large population control cohorts (2016) (352)
Insulin Action and Age: European Group for the Study of Insulin Resistance (EGIR) (1996) (351)
Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci (2015) (349)
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population (2014) (348)
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals (2016) (347)
Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer (2011) (335)
Guidelines on Diabetes, Pre-Diabetes, and Cardiovascular Diseases: Executive Summary (2007) (328)
Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men (2009) (328)
[Guidelines on diabetes, pre-diabetes, and cardiovascular diseases]. (2007) (321)
Insulin Resistance, Body Fat Distribution, and Sex Hormones in Men (1994) (320)
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile (2011) (313)
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis (2017) (308)
The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns. (2007) (306)
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2017) (294)
Multiple Abnormalities in Glucose and Energy Metabolism and Coordinated Changes in Levels of Adiponectin, Cytokines, and Adhesion Molecules in Subjects With Metabolic Syndrome (2004) (291)
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity (2014) (287)
Proteinuria predicts stroke and other atherosclerotic vascular disease events in nondiabetic and non-insulin-dependent diabetic subjects. (1996) (287)
Linkage of familial combined hyperlipidaemia to chromosome 1q21–q23 (1998) (286)
Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes. (1996) (283)
Ten year mortality and causes of death in patients with rheumatoid arthritis. (1985) (280)
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion (2012) (279)
Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance. (1990) (278)
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis (2018) (276)
Cardiovascular Disease in Type 2 Diabetes From Population to Man to Mechanisms (2010) (273)
Age of Onset and Type of Diabetes (1985) (271)
Lipids and Lipoproteins Predicting Coronary Heart Disease Mortality and Morbidity in Patients With Non-insulin-dependent Diabetes (1993) (270)
Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. (2003) (263)
Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans (2010) (262)
Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort (2015) (258)
Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography. (2006) (257)
Hyperinsulinemic microalbuminuria. A new risk indicator for coronary heart disease. (1995) (253)
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. (2000) (252)
A catalog of genetic loci associated with kidney function from analyses of a million individuals (2019) (252)
Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial (2009) (251)
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals (2018) (249)
Asymptomatic atherosclerosis and insulin resistance. (1991) (247)
Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women. (1999) (246)
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk (2016) (242)
Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men (2012) (240)
Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. (1999) (239)
Subjective Memory Complaints and Personality Traits in Normal Elderly Subjects (1994) (236)
Prevention of diabetes mellitus in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study: results from a randomized clinical trial. (2003) (235)
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension (2016) (234)
Lower-Extremity Amputations in Diabetic and Nondiabetic Patients: A population-based study in eastern Finland (1993) (233)
Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels (1998) (225)
Epidemiology of risk factors for cardiovascular disease in diabetes and impaired glucose tolerance. (1997) (224)
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. (2018) (221)
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort (2017) (220)
VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries. (1997) (220)
Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow. (1991) (217)
Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty. (2000) (217)
Prevalence of the metabolic syndrome and its components: findings from a Finnish general population sample and the Diabetes Prevention Study cohort. (2004) (213)
Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. (2002) (209)
Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance (2008) (208)
Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia. (1998) (207)
Microalbuminuria Precedes the Development of NIDDM (1994) (206)
Large-scale association analyses identify host factors influencing human gut microbiome composition (2020) (206)
Non‐Insulin‐Dependent Diabetes and Its Metabolic Control Are Important Predictors of Stroke in Elderly Subjects (1994) (206)
Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits (2012) (204)
The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth. (2002) (204)
Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance. (1999) (201)
FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells. (2013) (199)
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes (2009) (199)
Genetic evidence of assortative mating in humans (2017) (199)
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes (2011) (197)
Retinopathy Predicts Cardiovascular Mortality in Type 2 Diabetic Men and Women (2007) (197)
Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme (2010) (196)
Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with Type II diabetes (2000) (196)
Risk Factors Predicting Lower Extremity Amputations in Patients With NIDDM (1996) (195)
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity (2017) (193)
Cognitive Function in an Elderly Population With Persistent Impaired Glucose Tolerance (1998) (191)
Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation. (2004) (187)
Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men (2009) (187)
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study (2011) (185)
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility (2015) (185)
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. (2000) (184)
Smoking Is Independently Associated With High Plasma Insulin Levels in Nondiabetic Men (1996) (183)
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers (2020) (182)
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1 (2003) (180)
A Follow‐Up Study of Age‐Associated Memory Impairment: Neuropsychological Predictors of Dementia (1995) (179)
Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion (2007) (179)
Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability (2011) (179)
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry (2013) (178)
Ischemic heart disease risk in postmenopausal women. Effects of estrogen use on glucose and insulin levels. (1990) (178)
Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women (2012) (177)
Genetic Screening for the Risk of Type 2 Diabetes (2013) (177)
Lipids and glucose in type 2 diabetes: what is the cause and effect? (2004) (175)
Insulin resistance and coronary heart disease (1996) (172)
Plasma insulin and all-cause, cardiovascular, and noncardiovascular mortality: the 22-year follow-up results of the Helsinki Policemen Study. (2000) (172)
Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies. (2017) (171)
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. (2008) (170)
Femoropopliteal angioplasty in patients with claudication: primary and secondary patency in 140 limbs with 1-3-year follow-up. (1994) (170)
Visfatin is an adipokine, but it is not regulated by thiazolidinediones. (2006) (168)
Atherosclerotic Vascular Disease and Its Risk Factors in Non-Insulin-Dependent Diabetic and Nondiabetic Subjects in Finland (1988) (167)
The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. (2017) (167)
High-sensitivity C-reactive protein and coronary heart disease mortality in patients with type 2 diabetes: a 7-year follow-up study. (2006) (166)
Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women. (1995) (166)
Reduced postprandial skeletal muscle blood flow contributes to glucose intolerance in human obesity. (1990) (165)
Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels. (1999) (164)
The STOP-NIDDM Trial: An international study on the efficacy of an α-glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data (1998) (163)
Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands. (1998) (161)
Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention (2001) (160)
A Central Role for GRB10 in Regulation of Islet Function in Man (2014) (159)
Physical Activity and Insulin Sensitivity (2008) (157)
Elevated Plasma Homocysteine Level Is an Independent Predictor of Coronary Heart Disease Events in Patients with Type 2 Diabetes Mellitus (2004) (157)
Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population. (2002) (156)
Cardiovascular mortality in patients with rheumatoid arthritis. (1989) (156)
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study (2008) (155)
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults (2017) (153)
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls (2019) (153)
The Trans-Ancestral Genomic Architecture of Glycemic Traits (2020) (151)
Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. (2007) (150)
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits (2017) (149)
The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity. (2003) (148)
A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease (1988) (147)
Glycemic Control and the Risk for Coronary Heart Disease in Patients with Non-Insulin-dependent Diabetes Mellitus: The Finnish Studies (1996) (147)
Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity Published, JLR Papers in Press, June 1, 2004. DOI 10.1194/jlr.M300522-JLR200 (2004) (147)
Directional dominance on stature and cognition in diverse human populations (2015) (144)
Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality. (2019) (142)
Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study (2007) (141)
Immunoreactive interleukin-6 and acute phase proteins as prognostic factors in multiple myeloma. Finnish Leukemia Group. (1995) (141)
Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass (2012) (141)
Association of neck circumference with insulin resistance-related factors (2002) (140)
Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men Published, JLR Papers in Press, December 1, 2003. DOI 10.1194/jlr.M300368-JLR200 (2004) (139)
The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. (2005) (139)
Glycerol and Fatty Acids in Serum Predict the Development of Hyperglycemia and Type 2 Diabetes in Finnish Men (2013) (138)
Insulin receptor substrate-1 variants in non-insulin-dependent diabetes. (1994) (136)
WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4 (2013) (136)
Insulin resistance and depression: cross sectional study (2004) (136)
Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. Effects of insulin therapy. (1991) (135)
Hyperinsulinemia and the risk of stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. (1998) (133)
Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects. (1995) (132)
Association of Chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in Finland. (1996) (132)
High fasting plasma insulin is an indicator of coronary heart disease in non-insulin-dependent diabetic patients and nondiabetic subjects. (1991) (130)
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes (2012) (129)
The power of genetic diversity in genome-wide association studies of lipids (2021) (129)
An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance. (2005) (129)
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (2017) (127)
LDL size and risk of coronary heart disease in elderly men and women. (1999) (124)
Serum 25-Hydroxyvitamin D: A Predictor of Macrovascular and Microvascular Complications in Patients With Type 2 Diabetes (2014) (124)
Isolated Low HDL Cholesterol: An Insulin-Resistant State (1994) (123)
Enhanced Polyamine Catabolism Alters Homeostatic Control of White Adipose Tissue Mass, Energy Expenditure, and Glucose Metabolism (2007) (121)
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. (2011) (121)
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition (2018) (121)
The Common Variant in the FTO Gene Did Not Modify the Effect of Lifestyle Changes on Body Weight: The Finnish Diabetes Prevention Study (2009) (121)
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance. (2016) (121)
Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns (1998) (120)
Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms (2014) (120)
Common polymorphisms of the PPAR-γ2 (Pro12Ala) and PGC-1α (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial (2004) (120)
Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy (2012) (119)
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study (2008) (119)
Cardiovascular disease risk factors as predictors of Type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects (1993) (118)
Leptin concentrations, sex hormones, and cortisol in nondiabetic men. (1997) (118)
High Serum Levels of Advanced Glycation End Products Predict Increased Coronary Heart Disease Mortality in Nondiabetic Women but not in Nondiabetic Men: A Population-Based 18-Year Follow-Up Study (2005) (117)
Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. (2017) (117)
Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene. (1998) (116)
Fast Gene Ontology based clustering for microarray experiments (2008) (116)
Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained (2013) (116)
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases (2017) (114)
Dopaminergic system and monoamine oxidase-B Activity in Alzheimer's disease (1988) (114)
Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies (2018) (114)
Heart rate variability and its determinants in patients with severe or mild essential hypertension. (2001) (113)
Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes (2013) (113)
Exome sequencing of Finnish isolates enhances rare-variant association power (2019) (113)
Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. (1999) (112)
Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels (1992) (112)
Plasma insulin and serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetic and non-diabetic subjects. (1987) (111)
Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. (2010) (110)
Poor glycemic control predicts coronary heart disease events in patients with type 1 diabetes without nephropathy. (1999) (109)
Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men. (2001) (109)
Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data (2004) (108)
Leptin concentrations and insulin sensitivity in normoglycemic men (1997) (108)
Kinetics of In Vivo Muscle Insulin-Mediated Glucose Uptake in Human Obesity (1990) (106)
Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes. (2013) (106)
Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance (2010) (106)
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (2011) (104)
Asymptomatic hyperglycemia is associated with lipid and lipoprotein changes favoring atherosclerosis. (1989) (103)
Association of Ketone Body Levels With Hyperglycemia and Type 2 Diabetes in 9,398 Finnish Men (2013) (103)
Postchallenge Glucose, A1C, and Fasting Glucose as Predictors of Type 2 Diabetes and Cardiovascular Disease (2010) (103)
Retinopathy Predicts Coronary Heart Disease Events in NIDDM Patients (1996) (103)
Gastrointestinal symptoms in middle-aged diabetic patients. (1993) (102)
Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q. (2003) (102)
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018) (100)
Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling (2018) (99)
Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms of hyperglycemia in obese non-insulin-dependent diabetic subjects. (1988) (99)
The Relation of Proinsulin, Insulin, and Proinsulin-to-Insulin Ratio to Insulin Sensitivity and Acute Insulin Response in Normoglycemic Subjects (1997) (98)
Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus (2015) (98)
Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects. (1999) (98)
Serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetics. (1985) (97)
Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation (2013) (97)
Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland (2002) (97)
Genetic architecture of human plasma lipidome and its link to cardiovascular disease (2019) (96)
Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1. (2001) (96)
Apolipoprotein E phenotype is related to macro- and microangiopathy in patients with non-insulin-dependent diabetes mellitus. (1993) (96)
The genetic regulatory signature of type 2 diabetes in human skeletal muscle (2016) (96)
SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity (2010) (96)
Prevalence of Diabetes and Impaired Glucose Tolerance in Elderly Subjects and Their Association With Obesity and Family History of Diabete (1990) (94)
Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin. (2000) (94)
Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic finnish offspring of type 2 diabetic individuals. (2010) (93)
The association of apolipoprotein E polymorphism with memory: a population based study (1995) (93)
Impact of the Pro12Ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n-3 fatty acid supplementation. (2003) (93)
Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients. (2005) (93)
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids (2019) (93)
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease (2016) (92)
The Metabolic Syndrome Predicts Incident Stroke: A 14-Year Follow-Up Study in Elderly People in Finland (2008) (92)
Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue (1999) (90)
Electrocardiographic Alterations during Hyperinsulinemic Hypoglycemia in Healthy Subjects (2007) (90)
Incidence of rheumatoid arthritis in Finland during 1980-1990. (1996) (90)
[Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary]. (2006) (90)
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects. (2000) (90)
Transcript expression-aware annotation improves rare variant interpretation (2020) (89)
Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention. (2001) (89)
Insulin resistance is related to albuminuria in patients with type II (non-insulin-dependent) diabetes mellitus. (1993) (88)
Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry (2009) (88)
Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study. (2004) (88)
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation (2020) (88)
Pleiotropic Effects of GIP on Islet Function Involve Osteopontin (2011) (88)
Essential hypertension and insulin resistance in non‐insulin‐dependent diabetes (1989) (87)
Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors. (1997) (87)
Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease (2006) (86)
Hyperinsulinemia cluster predicts the development of type 2 diabetes independently of family history of diabetes. (1999) (86)
Evaluating drug targets through human loss-of-function genetic variation (2019) (86)
Subgroup and cost‐benefit analysis of the Finnish multicentre trial of clodronate in multiple myeloma (1994) (85)
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants (2017) (85)
Shift in the incidence of rheumatoid arthritis toward elderly patients in Finland during 1975-1990. (1996) (85)
Plasma fatty acids as predictors of glycaemia and type 2 diabetes (2015) (85)
Soluble interleukin‐6 receptor as a prognostic factor in multiple myeloma (1996) (85)
Reduction in Hexokinase II Levels Results in Decreased Cardiac Function and Altered Remodeling After Ischemia/Reperfusion Injury (2011) (85)
Mapping and characterization of structural variation in 17,795 human genomes (2020) (84)
Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans. (2012) (84)
Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. (2005) (84)
Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle (2019) (83)
Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response (2009) (83)
Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes. (2014) (83)
Prevalence of Retinopathy in People With Diabetes, Impaired Glucose Tolerance, and Normal Glucose Tolerance (1998) (83)
Risk for non‐insulindependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function (1997) (82)
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text (2007) (82)
G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia. (2000) (81)
Kinetics of Insulin-Mediated and Non-Insulin-Mediated Glucose Uptake in Humans (1990) (81)
Low insulin sensitivity measured by both quantitative insulin sensitivity check index and homeostasis model assessment method as a risk factor of increased intima-media thickness of the carotid artery. (2002) (81)
Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study. (2008) (81)
Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance (2013) (80)
A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes. (2011) (80)
Increased risk of non‐insulin-dependent diabetes mellitus in elderly hypertensive subjects (1994) (80)
The STOP-NIDDM Trial: an international study on the efficacy of an alpha-glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data. Study to Prevent Non-Insulin-Dependent Diabetes Mellitus. (1998) (79)
Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance (2017) (79)
Effects of 34 Risk Loci for Type 2 Diabetes or Hyperglycemia on Lipoprotein Subclasses and Their Composition in 6,580 Nondiabetic Finnish Men (2011) (79)
The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns. (2010) (79)
α‐Synuclein pathology is highly dependent on the case selection (2001) (79)
Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease (2017) (78)
Heart in Diabetes: A Microvascular Disease (2011) (78)
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2019) (78)
A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell. (2014) (78)
Hair Loss, Insulin Resistance, and Heredity in Middle-aged Women. a Population-based Study (2003) (77)
Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies (2021) (77)
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. (2019) (77)
Study of hadronic decays of the Z0 boson (1990) (77)
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. (2008) (77)
The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population. (1998) (77)
Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum. (2018) (76)
Myocardial infarct size and mortality in patients with non‐insulin‐dependent diabetes mellitus (1994) (76)
Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects. (1997) (76)
The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth. (2004) (75)
Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study (2005) (75)
Disruption of Hexokinase II–Mitochondrial Binding Blocks Ischemic Preconditioning and Causes Rapid Cardiac Necrosis (2011) (74)
Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice. (2003) (74)
Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes (2013) (74)
Biomarkers for type 2 diabetes (2019) (74)
Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity. (2016) (74)
The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface. (2009) (74)
Amino Acid Substitutions in Hexokinase II Among Patients With NIDDM (1995) (74)
Epidemiological evidence for the association of hyperglycaemia and atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus. (1996) (74)
Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women. (1998) (73)
Hyperinsulinemia predicts multiple atherogenic changes in lipoproteins in elderly subjects. (1994) (73)
The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects. (1996) (73)
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative (2018) (73)
Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns (1997) (73)
Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study (2011) (73)
Lipids and Lipoproteins Predicting Coronary Heart Disease Mortality and Morbidity in Patients With Non‐Insulin‐Dependent Diabetes (1993) (73)
Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population‐based study of 9399 Finnish men (2012) (72)
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease. (2017) (72)
Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with elevated blood pressure in type 2 diabetic patients with coronary heart disease (2000) (72)
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci (2019) (72)
Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism (2012) (72)
Relation of coronary heart disease and apolipoprotein E phenotype in patients with non-insulin dependent diabetes. (1991) (72)
First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the Asp175Asn mutation of the alpha-tropomyosin gene. (2003) (71)
Insulin sensitivity is not an independent determinant of plasma plasminogen activator inhibitor-1 activity. (1994) (71)
Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene. (2001) (71)
The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. (2004) (71)
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men (2019) (70)
Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia. (1997) (70)
Impaired left ventricular systolic function during exercise in middle-aged insulin-dependent and noninsulin-dependent diabetic subjects without clinically evident cardiovascular disease. (1988) (70)
Prognostic role of pro‐ and anti‐inflammatory cytokines and their polymorphisms in acute decompensated heart failure (2008) (69)
The effect of LRRK2 loss-of-function variants in humans (2020) (69)
Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice (2012) (69)
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. (2013) (69)
The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia. (2003) (69)
Cancer mortality in patients with rheumatoid arthritis. (1986) (69)
Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production (2012) (69)
Associations of autozygosity with a broad range of human phenotypes (2019) (68)
Association of Low HDL and HDL2 Cholesterol with Coronary Heart Disease in Noninsulin‐Dependent Diabetics (1985) (67)
A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy. (2004) (67)
PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION (2018) (67)
Benefits of strict glucose and blood pressure control in type 2 diabetes: lessons from the UK Prospective Diabetes Study. (1999) (66)
A nationwide study on parathyroid carcinoma (2017) (65)
Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis. (2004) (65)
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity (2019) (65)
A saturated map of common genetic variants associated with human height (2022) (65)
A Candidate Type 2 Diabetes Polymorphism Near the HHEX Locus Affects Acute Glucose-Stimulated Insulin Release in European Populations (2008) (64)
The relationship of glucose tolerance to sleep disorders and daytime sleepiness. (2005) (64)
Serum lipids, lipoproteins, and apolipoproteins and the excessive occurrence of coronary heart disease in non-insulin-dependent diabetic patients. (1989) (64)
Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men. (2006) (64)
Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects (1995) (63)
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci (2016) (63)
Variant near ADAMTS9 Known to Associate with Type 2 Diabetes Is Related to Insulin Resistance in Offspring of Type 2 Diabetes Patients—EUGENE2 Study (2009) (63)
Increased Atherosclerotic Lesion Calcification in a Novel Mouse Model Combining Insulin Resistance, Hyperglycemia, and Hypercholesterolemia (2007) (63)
Identification of new sequence variants in the leptin gene. (1998) (63)
Underlying genetic models of inheritance in established type 2 diabetes associations. (2009) (62)
Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney. (2016) (62)
Ketone body production is differentially altered in steatosis and non‐alcoholic steatohepatitis in obese humans (2015) (62)
Lipids and lipoproteins as risk factors for coronary heart disease in non-insulin-dependent diabetes mellitus. (1996) (62)
SIRT 3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome (2011) (62)
Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort (2016) (62)
Lipid and lipoprotein abnormalities associated with coronary heart disease in patients with insulin-dependent diabetes mellitus. (1986) (61)
Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes. (2000) (61)
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection (2021) (61)
Charged particle multiplicity distributions inZ0 hadronic decays (1991) (61)
K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population. (2003) (61)
Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes (2009) (61)
Mortality from amyloidosis and renal diseases in patients with rheumatoid arthritis. (1986) (61)
Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study1 (2010) (61)
Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage? (2015) (60)
Structure and Costs of Health Care of Diabetic Patients in Finland (1996) (60)
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS (2018) (60)
The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. (2005) (60)
Association of obesity and distribution of obesity with glucose tolerance and cardiovascular risk factors in the elderly. (1992) (60)
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape (2016) (59)
Impact of Positive Family History and Genetic Risk Variants on the Incidence of Diabetes (2011) (59)
Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse (2005) (59)
Effects of losartan on insulin sensitivity in hypertensive subjects. (1996) (59)
PROPORTIONALITY PROFILES OF WEST EUROPEAN ELECTORAL SYSTEMS (1980) (59)
A comparison of jet production rates on the Z0 resonance to perturbative QCD (1990) (59)
Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes (2004) (59)
Hyperglycemia as a risk factor for cardiovascular disease in type 2 diabetes. (1999) (58)
Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men? (1999) (58)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2020) (58)
The Pro12Ala Polymorphism of the PPARγ2 Gene Regulates Weight from Birth to Adulthood (2004) (58)
Effects of epinephrine on insulin-mediated glucose uptake in whole body and leg muscle in humans: role of blood flow. (1992) (58)
Polymorphism of the β3-Adrenergic Receptor Gene Affects Basal Metabolic Rate in Obese Finns (1997) (58)
Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: The Finnish Diabetes Prevention Study (2009) (58)
Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake. (2005) (58)
The European stroke prevention study (ESPS): Results by arterial distribution (1991) (58)
Astrogliosis and the ApoE Genotype (1999) (57)
Association of insulin resistance linked diseases and hair loss in elderly men. Finnish population-based study. (2006) (57)
Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women. (2009) (57)
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders (2019) (57)
Abnormalities in left ventricular diastolic function in male patients with rheumatoid arthritis without clinically evident cardiovascular disease (1993) (56)
Prevalence and associated factors of restless legs in a 57‐year‐old urban population in northern Finland (2009) (56)
Insulin resistance in familial and nonfamilial hypercholesterolemia. (1993) (56)
Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. (2004) (56)
Microbiota-Related Metabolites and the Risk of Type 2 Diabetes (2020) (56)
Identification of the UBP1 Locus as a Critical Blood Pressure Determinant Using a Combination of Mouse and Human Genetics (2009) (55)
Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps (2018) (55)
Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy (2005) (55)
European Stroke Prevention Study: Effectiveness of Antiplatelet Therapy in Diabetic Patients in Secondary Prevention of Stroke (1992) (55)
Relationship of LDL size to insulin sensitivity in normoglycemic men. (1997) (55)
The effects of the Pro12Ala polymorphism of the PPARγ‐2 gene on lipid metabolism interact with body size at birth (2003) (55)
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels. (2008) (55)
Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beta-myosin heavy chain, alpha-tropomyosin, and myosin-binding protein C genes. (2006) (54)
Cholesterol synthesis prevails over absorption in metabolic syndrome. (2007) (54)
Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow. (2000) (54)
The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function (2011) (54)
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (2020) (53)
The role of polygenic risk and susceptibility genes in breast cancer over the course of life (2020) (53)
Observation¶Effect of the Pro12Ala polymorphism of the PPAR-γ2 gene on long-term weight change in Finnish non-diabetic subjects (2001) (53)
SNPs in PPARG associate with type 2 diabetes and interact with physical activity. (2008) (53)
A Study of Intermittency in Hadronic Z0 Decays (1990) (53)
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. (2015) (53)
Population-Based Dementia Screening Program in Kuopio: The Effect of Education, Age, and Sex on Brief Neuropsychological Tests (1992) (53)
Association of the Leu72Met polymorphism of the ghrelin gene with the risk of Type 2 diabetes in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study (2006) (52)
Treatment of Hypercholesterolemia and Combined Hyperlipidemia With Simvastatin and Gemfibrozil in Patients With NIPPM: A multicenter comparison study (1998) (52)
Apolipoprotein E gene promoter (–219G/T) polymorphism is associated with premature coronary heart disease (2001) (52)
Depression after coronary heart disease events. (2000) (52)
Genetics of metabolic syndrome (2014) (52)
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. (2016) (52)
A Precise Measurement of the Z Resonance Parameters through its Hadronic Decays (1990) (52)
Effects of a very-low-calorie diet on metabolic control and cardiovascular risk factors in the treatment of obese non-insulin-dependent diabetics. (1990) (51)
Single Nucleotide Polymorphisms of the Peroxisome Proliferator–Activated Receptor-α Gene (PPARA) Influence the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes (2007) (51)
Gender differences in C‐reactive protein, interleukin‐1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population‐based study (2008) (51)
Identification of undiagnosed type 2 diabetic individuals by the finnish diabetes risk score and biochemical and genetic markers: a population-based study of 7232 Finnish men. (2010) (51)
Interactions between peroxisome proliferator-activated receptor-γ2 gene polymorphisms and size at birth on blood pressure and the use of antihypertensive medication (2004) (50)
The Trp64Arg Polymorphism of the β3-Adrenergic Receptor Gene: Lack of association with NIDDM and features of insulin resistance syndrome (1997) (50)
The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia. (2000) (50)
New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals (2017) (50)
Low levels of sex hormone-binding globulin and testosterone are associated with smaller, denser low density lipoprotein in normoglycemic men. (1996) (50)
Association between a deletion/insertion polymorphism in the α2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study (2004) (49)
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium (2014) (49)
Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects (2000) (49)
Gene variants, insulin resistance, and dyslipidaemia (2004) (49)
Asymptomatic hyperglycemia and cardiovascular risk factors in the elderly. (1991) (49)
Cardiovascular Risk Factors Associated With Insulin Resistance Cluster in Families With Early-Onset Coronary Heart Disease (2001) (49)
High plasma insulin level associated with coronary heart disease in the elderly. (1993) (49)
Effect of the Pro12Ala polymorphism of the PPAR-gamma2 gene on long-term weight change in Finnish non-diabetic subjects. (2001) (48)
Left ventricular systolic function in middle-aged patients with diabetes mellitus. (1994) (48)
Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men. (2015) (48)
Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol. (2015) (48)
Single Nucleotide Polymorphisms of PPARD in Combination With the Gly482Ser Substitution of PGC-1A and the Pro12Ala Substitution of PPARG2 Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes (2006) (48)
Phosphorylation Barriers to Skeletal and Cardiac Muscle Glucose Uptakes in High-Fat–Fed Mice (2007) (48)
A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. (2018) (48)
Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease. (2001) (47)
Hexokinase II-deficient Mice (1999) (47)
Long-term consumption of plant stanol and sterol esters, vascular function and genetic regulation (2008) (47)
Tumour necrosis factor-α gene haplotype is associated with pre-eclampsia (2005) (47)
Limited Overlap Between Intermediate Hyperglycemia as Defined by A1C 5.7–6.4%, Impaired Fasting Glucose, and Impaired Glucose Tolerance (2011) (47)
A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context (2018) (47)
Reducing the burden of diabetes: managing cardiovascular disease † (1999) (47)
Does NIDDM increase the risk for coronary heart disease similarly in both low- and high-risk populations? (1995) (46)
High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. (2014) (46)
Antiplatelet treatment does not reduce the severity of subsequent stroke (1999) (46)
Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study (2017) (46)
Dyslipidemia, morbidity, and mortality in non-insulin-dependent diabetes mellitus. Lipoproteins and coronary heart disease in non-insulin-dependent diabetes mellitus. (1997) (46)
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use (2019) (45)
Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns[S] (2017) (45)
Insulin Resistance and Depressive Symptoms in Young Adult Males: Findings From Finnish Military Conscripts (2007) (45)
Treatment With the Dipeptidyl Peptidase-4 Inhibitor Linagliptin or Placebo Followed by Glimepiride in Patients With Type 2 Diabetes With Moderate to Severe Renal Impairment: A 52-Week, Randomized, Double-Blind Clinical Trial (2015) (45)
Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study (2017) (45)
Role of RNA binding protein HuR in ductal carcinoma in situ of the breast (2011) (45)
Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling (2020) (45)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2019) (45)
Early abnormalities in coronary heart disease risk factors in relatives of subjects with non-insulin-dependent diabetes. (1992) (45)
Prevalence of isthmic lumbar spondylolisthesis in middle-aged subjects from eastern and western Finland. (1992) (45)
Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging (2006) (45)
Effect of the interleukin-6 (-174) g/c promoter polymorphism on adiponectin and insulin sensitivity. (2005) (45)
APOE polymorphism and the hypertriglyceridemic effect of dietary sucrose. (2001) (45)
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. (2017) (44)
Impairment of diastolic function in middle-aged Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patients free of cardiovascular disease (1988) (44)
A novel mutation, Arg71Thr, in the δ-sarcoglycan gene is associated with dilated cardiomyopathy (2003) (44)
Baroreflex sensitivity in essential and secondary hypertension (2002) (44)
Dietary fat predicts coronary heart disease events in subjects with type 2 diabetes. (2003) (44)
Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes (2004) (44)
Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study (2006) (44)
Levels of adiponectin, C‐reactive protein and interleukin‐1 receptor antagonist are associated with insulin sensitivity: a population‐based study (2008) (43)
Effect of a three-amino acid deletion in the α2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects (2001) (43)
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk (2017) (43)
Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern (2000) (43)
Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men (2011) (43)
Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study. (2008) (43)
A novel surrogate index for hepatic insulin resistance (2011) (42)
The Ala54Thr Polymorphism of the Fatty Acid Binding Protein 2 Gene Does Not Influence Insulin Sensitivity in Finnish Nondiabetic and NIDDM Subjects (1997) (42)
Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism. (2002) (42)
Effects of bezafibrate on insulin sensitivity and glucose tolerance in subjects with combined hyperlipidemia (1992) (42)
Antiplatelet therapy is effective in the prevention of stroke or death in women: subgroup analysis of the European stroke prevention study (ESPS) (1991) (42)
Changes in the prevalence and incidence of diabetes mellitus in Finnish adults, 1970-1987. (1991) (42)
Integrative platform to translate gene sets to networks (2010) (42)
Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp 175Asn mutation in the α-tropomyosin gene: A positron emission tomography study (2007) (41)
Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects. (2003) (41)
Physical activity and body composition changes during military service. (2009) (41)
Plasma insulin, serum lipids and lipoproteins in gall stone disease in non-insulin dependent diabetic subjects: a case control study. (1990) (41)
Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease. (2002) (40)
Insulin resistance and its impact on the approach to therapy of type 2 diabetes. (2001) (40)
Desmosterol in human nonalcoholic steatohepatitis (2013) (40)
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts (2020) (40)
Inflammatory response to dietary linoleic acid depends on FADS1 genotype. (2019) (40)
Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women (2005) (40)
Insulin Sensitivity and Carotid Intima-Media Thickness: Relationship Between Insulin Sensitivity and Cardiovascular Risk Study (2013) (40)
Asymptomatic Hyperglycemia and Atherosclerotic Vascular Disease in the Elderly (1992) (40)
Plant stanol esters lower LDL cholesterol level in statin-treated subjects with type 1 diabetes by interfering the absorption and synthesis of cholesterol. (2011) (40)
Dietary Fat in Relation to Erythrocyte Fatty Acid Composition in Men (2013) (40)
VEGF‐A, VEGF‐D, VEGF receptor‐1, VEGF receptor‐2, NF‐KB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits (2006) (39)
A Type 2 Diabetes–Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus (2017) (39)
Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution (2009) (39)
Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB (2015) (39)
Two novel mutations in the β‐myosin heavy chain gene associated with dilated cardiomyopathy (2004) (39)
Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects. (2008) (39)
An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis. (2012) (39)
Experimental Study of the Triple-Gluon Vertex (1991) (38)
Gender Differences Relating to Metabolic Syndrome and Proinflammation in Finnish Subjects with Elevated Blood Pressure (2009) (38)
Is Insulin Resistance a Feature of or a Primary Risk Factor for Cardiovascular Disease? (2015) (38)
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes (2017) (38)
Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci (2004) (38)
Diabetes Secondary to Treatment with Statins (2017) (38)
Associations between two single nucleotide polymorphismsin the adiponectin gene and polycystic ovary syndrome (2005) (38)
Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects (1997) (37)
Genetic study between SIRT1, PPARD, PGC-1α genes and Alzheimer’s disease (2008) (37)
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2016) (37)
Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells (2015) (37)
MspI polymorphism at +83 bp in intron 1 of the human apolipoprotein A1 gene is associated with elevated levels of HDL cholesterol and apolipoprotein A1 in nondiabetic subjects but not in type 2 diabetic patients with coronary heart disease. (2000) (37)
Both Fasting and Glucose-Stimulated Proinsulin Levels Predict Hyperglycemia and Incident Type 2 Diabetes: A Population-Based Study of 9,396 Finnish Men (2015) (37)
Metabolic syndrome in connection with BMI in young Finnish male adults. (2007) (37)
Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population (2013) (37)
The Effect of the −308A Allele of the TNF-α Gene on Insulin Action Is Dependent on Obesity (2003) (37)
Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity (2020) (36)
The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood. (2004) (36)
Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes. (2000) (36)
Adverse effects of obesity on lipid and lipoprotein levels in insulin-dependent and non-insulin-dependent diabetes. (1990) (36)
Additive Effects of Genetic Variation in GCK and G6PC2 on Insulin Secretion and Fasting Glucose (2009) (36)
Energy-energy correlations in hadronic final states from Z0 decays (1990) (36)
Design of a body-driven multiplayer game system (2006) (36)
New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes. (2001) (36)
Decreased plasma β‐amyloid in the Alzheimer's disease APP A673T variant carriers (2017) (36)
Somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with Parkinson's disease and its relation to dementia. (1986) (36)
The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease. (2009) (36)
Dual role of FoxA 1 in androgen receptor binding to chromatin , androgen signalling and prostate cancer (2011) (36)
Macrovascular complications in relation to hyperinsulinaemia in non-insulin-dependent diabetes mellitus. (1987) (35)
Is there a sex difference in the association of plasma insulin level and insulin sensitivity with serum lipids and lipoproteins? (1994) (35)
The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance (2001) (35)
Adipose Co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes (2012) (35)
Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss (2014) (35)
HLA genotyping is useful in the evaluation of the risk for coeliac disease in the 1st-degree relatives of patients with coeliac disease (2006) (34)
Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects. (2003) (34)
A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression. (2018) (34)
Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes. (2009) (34)
Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in nondiabetic Finnish offspring of type 2 diabetic individuals. (2015) (34)
A Search for sleptons and gauginos in Z0 decays (1990) (34)
Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney. (2016) (34)
Short Adult Stature Predicts Impaired &bgr;-Cell Function, Insulin Resistance, Glycemia, and Type 2 Diabetes in Finnish Men (2016) (34)
A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesity. (2003) (34)
Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes. (2004) (34)
Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle (2012) (34)
Reverse GWAS: Using genetics to identify and model phenotypic subtypes (2018) (34)
Second European Stroke Prevention Study: antiplatelet therapy is effective regardless of age (1999) (33)
Update on Type 2 Diabetes as a Cardiovascular Disease Risk Equivalent (2013) (33)
Visceral Obesity is Associated with High Levels of Serum Squalene (2006) (33)
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use (2019) (33)
A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1 (2013) (33)
Lipid and lipoprotein abnormalities in diabetic patients with peripheral vascular disease. (1988) (33)
Antihypertensive drugs as predictors of type 2 diabetes among subjects with impaired glucose tolerance. (2000) (33)
Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients. (2000) (33)
Prevalence of metabolic syndrome components among the elderly using three different definitions: A cohort study in Finland (2012) (33)
Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia? (1998) (33)
Physical Activity, High-Sensitivity C-Reactive Protein, and Total and Cardiovascular Disease Mortality in Type 2 Diabetes (2011) (33)
The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study. (2005) (32)
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility (2010) (32)
Molecular Cloning and Characterization of the Human PED/PEA-15 Gene Promoter Reveal Antagonistic Regulation by Hepatocyte Nuclear Factor 4α and Chicken Ovalbumin Upstream Promoter Transcription Factor II* (2008) (32)
A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study (2017) (31)
Insulin resistance is related to left ventricular hypertrophy in patients with polycystic kidney disease type 1. (2003) (31)
Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies (2020) (31)
Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome (2007) (31)
Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene. (2005) (31)
The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain. (2004) (31)
Genetics of Type 2 Diabetes. (2016) (31)
Association Analysis of Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms and Late Onset Alzheimer’s Disease in the Finnish Population (2006) (31)
Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. (2007) (31)
Atherosclerotic Vascular Disease in Middle‐Aged, Insulin‐Treated, Diabetic Patients: Association with Endogenous Insulin Secretion Capacity (1988) (30)
Insulin Secretion and Its Determinants in the Progression of Impaired Glucose Tolerance to Type 2 Diabetes in Impaired Glucose-Tolerant Individuals The Finnish Diabetes Prevention Study (2012) (30)
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology (2017) (30)
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B (2011) (30)
Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes (2007) (30)
Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men. (2005) (30)
Human hexokinase II: sequence and homology to other hexokinases. (1993) (30)
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels (2012) (29)
Exercise during military training improves cardiovascular risk factors in young men. (2011) (29)
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study (2018) (29)
Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes (2020) (29)
Monitoring the action of clodronate with type I collagen metabolites in multiple myeloma. (1996) (29)
Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with the relative change in body mass index between childhood and adulthood (2007) (29)
Exercise during military training improves cardiovascular risk factors in young men. (2011) (29)
Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men. (2016) (29)
Search For Heavy Charged Scalars In Z0 Decays (1990) (29)
Cardiac adrenergic innervation is affected in asymptomatic subjects with very early stage of coronary artery disease. (2002) (29)
High‐density lipoprotein‐cholesterol and not HbA1c was directly related to cardiovascular outcome in PROactive (2011) (29)
Unacylated ghrelin is associated with changes in body composition and body fat distribution during long-term exercise intervention. (2011) (29)
Search for pair production of neutral higgs bosons in z0 decays (1990) (29)
Operation and radiation resistance of a FOXFET biasing structure for silicon strip detectors (1993) (29)
IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy. (2008) (29)
Femoral atherosclerosis in middle-aged subjects: association with cardiovascular risk factors and insulin resistance. (1996) (29)
Apolipoprotein E Phenotype Alone Does Not Influence Survival in Alzheimer’s Disease: A Population-Based Longitudinal Study (2000) (28)
Inverse relationship of serum HDL and HDL2 cholesterol to C-peptide level in middle-aged insulin-treated diabetics. (1985) (28)
Lack of association between sex hormones and Lp(a) concentrations in American and Finnish men. (1994) (28)
n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies (2021) (28)
Interactions between peroxisome proliferator-activated receptor gene polymorphism and birth length influence risk for type 2 diabetes. (2003) (28)
Disentangling the genetics of lean mass. (2019) (28)
Long-term association of cardiovascular risk factors with impaired insulin secretion and insulin resistance. (2000) (28)
Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies. (2019) (28)
The G‐250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP‐NIDDM trial (2005) (28)
Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits. (2019) (28)
The D299G/T399I Toll-Like Receptor 4 Variant Associates with Body and Liver Fat: Results from the TULIP and METSIM Studies (2010) (28)
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. (2019) (28)
High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients (2005) (27)
INTERLEUKIN-6 PROMOTER POLYMORPHISM AND LATE-ONSET ALZHEIMER's DISEASE IN THE FINNISH POPULATION (2005) (27)
Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population. (2016) (27)
SIRT 1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity (2010) (27)
Galanin Preproprotein Is Associated With Elevated Plasma Triglycerides (2009) (27)
Anduril 2: upgraded large-scale data integration framework (2019) (27)
Interleukin 1 Alpha Gene Polymorphism as a Susceptibility Factor in Alzheimer’s Disease and Its Influence on the Extent of Histopathological Hallmark Lesions of Alzheimer’s Disease (2002) (27)
Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes (2007) (27)
Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease. (2002) (27)
Cardiac adrenergic activity is associated with left ventricular hypertrophy in genetically homogeneous subjects with hypertrophic cardiomyopathy. (2003) (26)
Epigenome-wide association in adipose tissue from the METSIM cohort (2018) (26)
Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue. (1999) (26)
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice (2020) (26)
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium (2019) (26)
Insulin Secretion and Its Determinants in the Progression of Impaired Glucose Tolerance to Type 2 Diabetes in Impaired Glucose-Tolerant Individuals (2012) (26)
Health-related quality of life and physical well-being among a 63-year-old cohort of women with androgenetic alopecia; a Finnish population-based study (2005) (26)
Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population (2003) (26)
Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes (2005) (25)
Influence of endogenous NEFA on beta cell function in humans (2015) (25)
Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution. (2019) (25)
A novel mutation, Arg71Thr, in the delta-sarcoglycan gene is associated with dilated cardiomyopathy. (2003) (25)
Autonomic nervous function and its relationship to cardiac performance in middle‐aged diabetic patients without clinically evident cardiovascular disease (1992) (25)
Glucose control in diabetes: which target level to aim for? (2012) (25)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (2017) (25)
Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced β-cell function in non-diabetic subjects (2009) (25)
The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism. (2003) (24)
The ATF6-Met[67]Val Substitution Is Associated With Increased Plasma Cholesterol Levels (2009) (24)
Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study (2017) (24)
Interaction of the -308G/A promoter polymorphism of the tumor necrosis factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population. (2006) (23)
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults (2000) (23)
The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients. (1999) (23)
No variants in the cardiac actin gene in Finnish patients with dilated or hypertrophic cardiomyopathy. (2002) (23)
Adiponectin gene haplotype is associated with preeclampsia. (2006) (23)
Prevention of type 2 diabetes. (2005) (23)
Prevalence of low back pain and other musculoskeletal symptoms and their association with work in Finnish reindeer herders. (1991) (23)
Associations of Total Testosterone and Sex Hormone–Binding Globulin Levels With Insulin Sensitivity in Middle-Aged Finnish Men (2007) (23)
Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci (2022) (22)
Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia. (1998) (22)
Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion (2015) (22)
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes (2021) (22)
The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes. (2013) (22)
The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol: The KANWU Study. (2008) (22)
Tumour necrosis factor-alpha gene haplotype is associated with pre-eclampsia. (2005) (22)
Obese men with type IIB hyperlipidemia are insulin resistant. (1993) (22)
Understanding patient needs Diabetology for cardiologists (2003) (22)
Death certificate and mortality in rheumatoid arthritis. (1986) (22)
The movement patterns and the experiential components of virtual environments (2009) (22)
A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis. (2007) (22)
An intronic variant in the GCKR gene is associated with multiple lipids (2019) (21)
Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes (2006) (21)
The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young finnish men (2006) (21)
Antiplatelet treatment in elderly people with transient ischaemic attacks or ischaemic strokes (1995) (21)
Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion. (2002) (21)
Relationship of plasma insulin concentration and insulin sensitivity to blood pressure. Is it modified by obesity? (1996) (21)
Should a Two-and-a-Half Law Replace the Cube Law in British Elections? (1979) (21)
The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis (2012) (21)
Efficient estimation and applications of cross-validated genetic predictions (2019) (21)
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis (2010) (21)
Variants of the Fatty Acid-Binding Protein 2 Gene Are Not Associated With Coronary Heart Disease in Nondiabetic Subjects and in Patients With NIDDM (1998) (21)
Erratum: The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue (Cell Reports (2017) 19(12) (2451–2461) (S2211124717307519) (10.1016/j.celrep.2017.05.077)) (2017) (21)
Effect of the Pro12Ala polymorphism of the PPARγ2 gene on serum adiponectin changes (2005) (21)
Insulin Sensitivity and Lp(a) Concentrations in Normoglycemic Men (1995) (21)
AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis (2016) (21)
Single nucleotide polymorphisms of the HNF4α gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial (2006) (21)
Association between liver insulin resistance and cardiovascular risk factors (2012) (21)
Metabolic Syndrome and Incident End-Stage Peripheral Vascular Disease (2007) (20)
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2017) (20)
Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells (2017) (20)
Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells (2017) (20)
Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort (2016) (20)
Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic cardiomyopathy (2016) (20)
Long‐term effects of pioglitazone and metformin on insulin sensitivity in patients with Type 2 diabetes mellitus (2005) (20)
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116)) (2010) (20)
Elevated circulating follistatin associates with an increased risk of type 2 diabetes (2021) (20)
Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy (2019) (20)
Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene. (2004) (20)
Impact of Risk Factors on Limb Salvage After Angioplasty in Chronic Critical Lower Limb Ischemia (1994) (20)
Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes. (2015) (19)
The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance (2020) (19)
Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort (2021) (19)
Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. (2019) (19)
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration (2019) (19)
The Trp64Arg polymorphism of the beta 3-Adrenergic receptor gene. Lack of association with NIDDM and features of insulin resistance syndrome. (1997) (19)
The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity. (2003) (19)
The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM (1997) (19)
Changes in autonomic nervous function during the 4‐year follow‐up in middle‐aged diabetic and nondiabetic subjects initially free of coronary heart disease (1997) (19)
High circulating levels of RBP4 and mRNA levels of aP2, PGC‐1α and UCP‐2 predict improvement in insulin sensitivity following pioglitazone treatment of drug‐naïve type 2 diabetic subjects (2008) (19)
Lipids in type 2 diabetes. (2002) (18)
Genetic diversity fuels gene discovery for tobacco and alcohol use (2022) (18)
Variance of the SGK1 Gene Is Associated with Insulin Secretion in Different European Populations: Results from the TUEF, EUGENE2, and METSIM Studies (2008) (18)
Decreased plasma C‐reactive protein levels in APOE ε4 allele carriers (2018) (18)
Search for scalar quarks in Z0 decays (1990) (18)
The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study. (2010) (18)
Evidence of How rs7575840 Influences Apolipoprotein B–Containing Lipid Particles (2011) (18)
Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice (2011) (18)
Improvement of left ventricular function after starting insulin treatment in patients with non-insulin-dependent diabetes. (1988) (18)
Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance. (2005) (18)
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2 (2021) (18)
Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia. (2006) (18)
Markers of Tissue-Specific Insulin Resistance Predict the Worsening of Hyperglycemia, Incident Type 2 Diabetes and Cardiovascular Disease (2014) (18)
Non-Cholesterol Sterol Levels Predict Hyperglycemia and Conversion to Type 2 Diabetes in Finnish Men (2013) (18)
Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus (2017) (18)
Structure of the human hexokinase II gene. (1994) (17)
European stroke prevention study (ESPS): antithrombotic therapy is also effective in the elderly (1993) (17)
Association of Structural Variation with Cardiometabolic Traits in Finns (2020) (17)
Measurement of the Partial Width of the Decay of the Z0 into Charm Quark Pairs (1990) (17)
Bisphosphonates in multiple myeloma: current status; future perspectives. (1996) (17)
The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome. (2004) (17)
The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge (2011) (17)
Search for the t and b' Quarks in Hadronic Decays of the Z0 Boson (1990) (17)
Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes (2018) (17)
Damage observed in silicon diodes after low energy pion irradiation (1995) (17)
Glucokinase Gene Islet Promoter Region Variant (G→A) at Nucleotide −30 Is Not Associated With Reduced Insulin Secretion in Finns (1998) (17)
Risk factors and antiplatelet therapy in TIA and stroke patients (1998) (17)
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (17)
Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers (2015) (16)
DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival (2016) (16)
Cardiomyopathy associated with the Ala143Thr variant of the α-galactosidase A gene (2020) (16)
Identification and Functional Characterization of G 6 PC 2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G 6 PC 2-ABCB 11 Locus (2015) (16)
Blood pressure and atherosclerotic plaques in carotid, aortic and femoral arteries in elderly Finns with diabetes mellitus or impaired glucose tolerance (2005) (16)
Glucokinase Gene Variants in Subjects With Late-Onset NIDDM and Impaired Glucose Tolerance (1995) (16)
Common variants in β2‐ and β3‐adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes.  The Finnish Diabetes Prevention Study (2004) (16)
Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects. (2007) (16)
Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects. (2010) (16)
Polymorphisms in the ABCG 5 and ABCG 8 genes associate with cholesterol absorption and insulin sensitivity (2004) (16)
Dyslipidaemias, insulin resistance and atherosclerosis. (1992) (16)
Relationship between postheparin plasma lipases and high-density lipoprotein cholesterol in different types of diabetes (1987) (16)
Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia (2002) (16)
Hypertension and macrovascular disease--the killing fields of NIDDM. (1998) (16)
The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia–reperfusion injury (2011) (15)
Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial (2015) (15)
Association between Chlamydia pneumoniae antibodies and intimal calcification in femoral arteries of nondiabetic patients. (2002) (15)
Reduction in metabolic syndrome among obese young men is associated with exercise-induced body composition changes during military service. (2012) (15)
The association between erectile dysfunction, depressive symptoms and testosterone levels among middle-aged men (2014) (15)
Gly82Ser polymorphism of the receptor of advanced glycation end product gene is not associated with coronary heart disease in Finnish nondiabetic subjects or in patients with type 2 diabetes. (2000) (15)
The Maximum Distortion and the Problem of the First Divisor of Different P.R. Systems (1979) (15)
Recruiting High-Risk Individuals to a Diabetes Prevention Program (2007) (15)
Stopping insulin treatment in middle-aged diabetic patients with high postglucagon plasma C-peptide. Effect on glycaemic control, serum lipids and lipoproteins. (2009) (15)
Hyperproinsulinemia is not a characteristic feature in the offspring of patients with different phenotypes of type II diabetes. (2000) (15)
Perspectives in Diabetes Hyperglycemia and Cardiovascular Disease in me 2 Diabetes (1999) (15)
Insulin resistant phenotype is associated with high serum leptin levels in offspring of patients with non-insulin-dependent diabetes mellitus. (1998) (15)
Model-based assessment of replicability for genome-wide association meta-analysis (2021) (15)
Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (2011) (15)
The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy (2015) (15)
Field oxide radiation damage measurements in silicon strip detectors (1993) (14)
Diabetology for cardiologists (2003) (14)
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention (2022) (14)
Genetic analysis of over one million people identifies 535 novel loci for blood pressure (2017) (14)
Serum homocysteine, creatinine, and glucose as predictors of the severity and extent of coronary artery disease in asymptomatic members of high‐risk families (2002) (14)
Circulating RNAs as predictive markers for the progression of type 2 diabetes (2019) (14)
Familial aggregation of non-insulin dependent diabetes and coronary heart disease are accompanied by different effects on serum lipids, lipoproteins and apolipoproteins. (1991) (14)
Factors Associated With Fasting and Postglucagon Plasma C-Peptide Levels in Middle-Aged Insulin-Treated Diabetic Patient (1989) (14)
A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors (2017) (14)
ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition (2020) (14)
Associations of blood pressure with carotid intima-media thickness in elderly Finns with diabetes mellitus or impaired glucose tolerance (2003) (14)
Not for the eyes only: PAX6 and glucose metabolism (2009) (14)
Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease (2019) (14)
Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects. (2003) (13)
Long-Term Effects of Placental Growth on Overweight and Body Composition (2012) (13)
Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the α tropomyosin gene: magnetic resonance imaging study (2006) (13)
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells (2022) (13)
A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy (2014) (13)
Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns (2005) (13)
Search for low mass Higgs bosons produced inZ0 decays (1991) (13)
Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits (2019) (13)
Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans (2018) (13)
Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance (1995) (13)
Identification of sample-specific regulations using integrative network level analysis (2015) (12)
The cardiac troponin I gene is not associated with hypertrophic cardiomyopathy in patients from eastern Finland. (1999) (12)
Prolonged corrected QT interval is associated with acute and chronic hyperinsulinemia in nondiabetic subjects. (2003) (12)
Prevalence of Insulin Deficiency Among Initially Non-Insulin-Dependent Middle-Aged Diabetic Individuals (1986) (12)
Genetics of human gut microbiome composition (2020) (12)
Partial hexokinase II knockout results in acute ischemia–reperfusion damage in skeletal muscle of male, but not female, mice (2010) (12)
LMNA Mutation c.917T>G (p.L306R) Leads to Deleterious Hyper‐Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and Premature Aging (2015) (12)
Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT-DETECT prediction model - a DIRECT study (2017) (12)
Germline variation in TP53 regulatory network genes associates with breast cancer survival and treatment outcome (2013) (12)
Efficacy of antiplatelet treatment in hypertensive patients with TIA or stroke. (1998) (12)
Data integration to prioritize drugs using genomics and curated data (2016) (12)
Association of low‐insulin sensitivity measured by quantitative insulin sensitivity check index with hair loss in 55‐year‐old men. A Finnish population‐based study (2006) (12)
Metabolic syndrome: To be or not to be? (2006) (12)
Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes. (2000) (12)
Reverse gene-environment interaction approach to identify variants influencing body-mass index in humans (2019) (12)
Cardiovascular protection for all individuals at high risk: evidence-based best practice (2008) (12)
Single Nucleotide Polymorphisms of the MCHR1 Gene Do Not Affect Metabolism in Humans (2007) (12)
Regulation of alternative splicing in human obesity loci (2016) (11)
Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and Subtypes (2018) (11)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Atherosclerosis and cardiovascular risk reduction with PPAR agonists (2007) (11)
Thoracoabdominal Calcifications Predict Cardiovascular Disease Mortality in Type 2 Diabetic and Nondiabetic Subjects (2009) (11)
Cerebrovascular disease in type 2 diabetes (2007) (11)
Machine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose Regulation (2020) (11)
Interactions between genetic variation and cellular environment in skeletal muscle gene expression (2017) (11)
High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint. (2011) (11)
Association of abnormal glucose tolerance with self-reported sleep apnea among a 57-year-old urban population in Northern Finland. (2008) (11)
Metabolic and dietary variables associated with glycaemic control in patients with recently diagnosed type II diabetes mellitus (1994) (11)
Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data. (2008) (11)
Effects of Two Fat‐Modified Diets on Glucose and Lipid Metabolism in Healthy Subjects (1993) (10)
G-250 A Substitution in Promoter of Hepatic Lipase Gene Is Associated With Dyslipidemia and Insulin Resistance in Healthy Control Subjects and in Members of Families With Familial Combined Hyperlipidemia (2000) (10)
Pathogenesis and treatment of diabetic vascular disease – illustrated by two cases (2006) (10)
Repeatability of C-peptide response in glucagon stimulation test. (1987) (10)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (10)
Polymorphism in the peroxisome proliferator-activated receptor-γ gene in women with preeclampsia (2002) (10)
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study (2021) (9)
Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation (2019) (9)
Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes (2021) (9)
Clodronate for multiple myeloma (1993) (9)
Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults (2017) (9)
Proportional Representation in Scandinavia: Implications for Finland (1978) (9)
Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis. (2012) (9)
Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart. (2017) (9)
Abstract 3693: Effects of fenofibrate on silent myocardial infarction, hospitalization for acute coronary syndromes and amputation in type 2 diabetes: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study (2007) (9)
Diabetes as a 'cardiovascular disease equivalent': implications for treatment (2008) (9)
The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus. (2009) (9)
Antiplatelet therapy is effective in primary prevention of myocardial infarction in patients with a previous cerebrovascular ischemic event. (1993) (9)
Lipid disorders in type 2 diabetes. (2009) (9)
Partial trisomy 10q with mild phenotype caused by an unbalanced X;10 translocation (2003) (9)
Association analysis and meta-analysis of multiallelic variants for large-scale sequence data (2020) (9)
Practical navigation in virtual architectural environments (2001) (9)
Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes (2021) (9)
Association of Common Genetic Variation in The FOXO1 Gene with β-Cell Dysfunction, Impaired Glucose Tolerance, And Type 2 Diabetes (2009) (8)
The genetic and metabolic determinants of cardiovascular complications in type 2 diabetes: recent insights from animal models and clinical investigations. (2013) (8)
Type 2 Diabetes Mellitus and Dyslipidemia (2015) (8)
The FADS1 Genotype Modifies Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2. (2021) (8)
Simultaneous hypertrophic cardiomyopathy and ventricular septal defect in children. (1999) (8)
Molecular epidemiology of hereditary ataxia in Finland (2021) (8)
Hyperglycemia and cardiovascular disease in patients with type 2 diabetes (2000) (8)
Thresholds for Proportional Representation: Reanalized and Extended (1987) (8)
Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease. (2005) (8)
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study (2020) (8)
SOTALOL AND THE Q-TC INTERVAL (1981) (8)
Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes (2020) (8)
Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits : (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x) (2018) (8)
Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (2017) (8)
Status of the DELPHI vertex detector: Alignment methods and geometrical resolution (1990) (8)
Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism. (2020) (8)
Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models. (2013) (8)
Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: the effect of improved glycemic control. (2007) (8)
Erratum to Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer [Cancer Cell 24, (2004) 213-228] (2013) (8)
Lack of effect of hepatic enzyme induction on metabolic control in patients with type 2 (non‐insulin‐dependent) diabetes (1987) (8)
Genetics of Type 2 Diabetes: Past, Present, and Future (2022) (8)
Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences (2020) (7)
The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. (2017) (7)
An association between a subset of Finnish late-onsetAlzheimer’s disease and alpha2-macroglobulin (2001) (7)
Proteinuria modifies the effect of systolic blood pressure on total and cardiovascular disease mortality in patients with type 2 diabetes (2012) (7)
Association of serum lipids and lipoproteins with plasma C-peptide concentration in non-insulin-dependent diabetic and non-diabetic subjects. (1987) (7)
Prolonged P wave duration predicts stroke mortality among type 2 diabetic patients with prevalent non-major macrovascular disease (2014) (7)
Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease. (2018) (7)
The Metabolic Syndrome Predicts Incident Stroke (2008) (7)
The “Common Soil Hypothesis” Revisited—Risk Factors for Type 2 Diabetes and Cardiovascular Disease (2021) (7)
3D visualization of building services in virtual environment (2001) (7)
Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 Gene (2016) (7)
Serum 25-Hydroxy Vitamin D : A Predictor of Macrovascular and Microvascular Complications in Patients With Type 2 Diabetes (2014) (7)
Clinical characteristics in the discrimination between patients with low or high C-peptide level among middle-aged insulin-treated diabetics. (1987) (7)
Abstract 983: Protection Against Nephropathy With Fenofibrate in Type 2 Diabetes Mellitus: The FIELD Study (2009) (7)
Electoral Justice as a Criterion for Different Systems of Proportional Representation (1980) (7)
Long term effects of a very low calorie diet on metabolic control and cardiovascular risk factors in the treatment of obese non-insulin-dependent diabetics. (1989) (7)
Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb. (2004) (6)
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study (2020) (6)
New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland (1997) (6)
Carriers of an Inactivating -Cell ATP-Sensitive K Channel Mutation Have Normal Glucose Tolerance and Insulin Sensitivity and Appropriate (2002) (6)
Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition (2018) (6)
Associations of microalbuminuria and blood pressure with carotid, aortic and femoral atheromatous plaques in elderly Finns. (2005) (6)
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids (2021) (6)
Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries (2018) (6)
Family history of coronary heart disease is a stronger predictor of coronary heart disease morbidity and mortality than family history of non-insulin dependent diabetes mellitus. (1996) (6)
Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family. (2017) (6)
Fasting, postprandial and postprandial plus glucagon-stimulated plasma C-peptide levels in non-insulin-dependent diabetics and in control subjects. (2009) (6)
Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects. (2003) (6)
Ten-year natural course of habitual snoring and restless legs syndrome in a population aged 61–63 years at the baseline (2012) (6)
A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients (2005) (6)
Polymorphism Pro12Ala of PPARG in Prepubertal Children with Premature Adrenarche and Its Association with Growth in Healthy Children (2010) (6)
Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences (2020) (5)
Insulin resistance and cardiovascular disease (2002) (5)
Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk (2017) (5)
Exome array analysis identifies novel loci and low-frequency variants for insulin processing and secretion (2013) (5)
Novel electrocardiographic features in carriers of hypertrophic cardiomyopathy causing sarcomeric mutations. (2018) (5)
Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders (2018) (5)
Role of osteopontin and its regulation in pancreatic islet. (2018) (5)
Demonstration of disturbed free fatty acid metabolism of myocardium in patients with non-insulin-dependent diabetes mellitus as measured with iodine-123-heptadecanoic acid (2004) (5)
Genetic variation of FTO and TCF7L2 in premature adrenarche. (2009) (5)
Added Value of Vaisala AQT530 Sensors as a Part of a Sensor Network for Comprehensive Air Quality Monitoring (2021) (5)
Potentially Visible Set ( PVS ) (2003) (5)
Association of sequence variations in the gene encoding adiponectin receptor I (ADIPOR 1) with body size and insulin levels. (2006) (5)
Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia (2018) (5)
Erratum: Epigenome-wide association in adipose tissue from the METSIM cohort [Human Molecular Genetics., 27, 10, (2018), (1830-1846)] DOI: 10.1093/hmg/ddy093 (2018) (5)
Novel biomarkers associated with incident heart failure in 10 106 Finnish men (2020) (5)
A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia. (2001) (5)
Distributed systems design flow: fieldbus modeling (2008) (5)
Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults. (2005) (5)
Long-term influence of glycaemic control on cardiovascular risk in NIDDM. (1996) (5)
Proteinuria modifies the effects of physical activity on total and cardiovascular disease mortality rates in patients with type 2 diabetes (2010) (5)
Use of clodronate in multiple myeloma. (1995) (5)
Effect of lifestyle intervention on the risk of incident diabetes in individuals with impaired fasting glucose and low or high genetic risk for the development of type 2 diabetes in men: a T2D-GENE trial (2021) (5)
Association Between High-Sensitive Measurement of C-Reactive Protein and Metabolic Syndrome as Defined by International Diabetes Federation, National Cholesterol Education Program, and World Health Organization Criteria in a Population-Based Cohort of 55-Year-Old Finnish Individuals (2006) (5)
Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans (2013) (5)
Erratum: Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene (American Society for Clinical Investigation (2015)125:4 (1739-1751) DOI 10.1172/JCI74692) (2016) (5)
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells (2020) (4)
Postchallenge Glucose, HbA 1c , and Fasting Glucose as Predictors of Type 2 Diabetes and Cardiovascular Disease: A 10-year Prospective Cohort Study (2010) (4)
Systematic Use of Computational Methods Allows Stratifying Treatment Responders in (2011) (4)
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies (2022) (4)
The Effect of the Ala 12 Allele of the Peroxisome Proliferator-Activated Receptor- (cid:1) 2 Gene on Skeletal Muscle Glucose Uptake Depends on Obesity: A Positron Emission Tomography Study (2005) (4)
Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study (2020) (4)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (4)
Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk (2022) (4)
Metabolic defects in persistent impaired glucose tolerance are related to the family history of non-insulin-dependent diabetes mellitus. (1995) (4)
Variable effects of statins on glucose homeostasis parameters and their diabetogenic role. Reply to Kostapanos MS, Agouridis AP and Elisaf MS [letter] (2015) (4)
INSULIN GENE VARIABLE NUMBER OF TANDEM REPEAT GENOTYPE, EARLY GROWTH AND GLUCOSE METABOLISM IN ADULT LIFE (2006) (4)
Identification of genetic markers with synergistic survival effect in cancer (2013) (4)
Subcutaneous adipose tissue splice quantitative trait loci reveal differences in isoform usage associated with cardiometabolic traits. (2022) (4)
Progression of Kidney Disease Varies Between Families with Defects in the Polycystic Kidney Disease Type 1 Gene in Eastern Finland (2003) (4)
Oxidised LDL and progression of atherosclerosis (1992) (4)
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals (2022) (4)
Left Ventricular Systolic Function in MiddleAged Patients with Diabetes Mellitus (1994) (4)
Operative treatment for the painful posterior thigh after hamstring autograft harvesting. (2017) (4)
Evaluation of Heart Size and Pulmonary Vasculature (1991) (4)
CLODRONATE FOR MULTIPLE MYELOMA. AUTHOR'S REPLY (1993) (4)
Chlorpropamide-alcohol flushing and coronary heart disease in non-insulin dependent diabetics. (1983) (4)
Epigenome-wide association in adipose tissue from the METSIM cohort. (2018) (4)
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (2018) (4)
Simvastatin profoundly impairs energy metabolism in primary human muscle cells (2020) (4)
Postprandial metabolism of apolipoproteins B48, B100, C-III, and E in humans with APOC3 loss-of-function mutations (2022) (3)
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (2017) (3)
Supplementary Material 3 (2015) (3)
Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study. (2021) (3)
Association Analysis and Meta-Analysis of Multi-allelic Variants for Large Scale Sequence Data (2017) (3)
Exome sequencing of Finnish isolates enhances rare-variant association power (2019) (3)
Local adventitial VEGF gene transfer reduces neointima formation in rabbit carotid arteries (1996) (3)
35th Annual Meeting of the European Association for the Study of Diabetes (2016) (3)
Functional consequences of naturally occurring variants of human hexokinase II (1998) (3)
Supplementary Material 6 (2014) (3)
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium (2018) (3)
Riker's 'Size Principle' and Its Application to Finnish Roll-Call Data (1972) (3)
Metabolite Signature of Simvastatin Treatment Involves Multiple Metabolic Pathways (2022) (3)
The association of nine amino acids with cardiovascular events in Finnish men in a 12-year follow-up study. (2021) (3)
Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes (2004) (3)
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19 (2022) (3)
High-performance computing in biomedicine (2013) (3)
Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans (2021) (3)
Candidate genes for insulin resistance: what's new? (2003) (3)
Plasma Cell Membrane Glycoprotein-1 K121Q Polymorphism in Preeclampsia (2006) (3)
Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer's disease. (2020) (3)
Patients with Familial Combined Hyperlipidemia : A Precursor Defect for Dyslipidemia ? Impaired Insulin-Stimulated Glucose Oxidation and Free Fatty Acid Suppression in (1998) (3)
Supplementary Material 5 (2014) (3)
Computational identification of candidate loci for recessively inherited mutation using high-throughput SNP arrays (2007) (3)
An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease (2020) (3)
Metabolite Signature of Physical Activity and the Risk of Type 2 Diabetes in 7271 Men (2022) (3)
Data Related to Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use (2019) (3)
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity (2020) (3)
COOPERATIVENESS IN A MULTI-PARTY SYSTEM: A MEASURE AND AN APPLICATION (1975) (3)
Supplementary Material 7 (2014) (3)
Syddansk Universitet Association analysis of 29 , 956 individuals confirms that a low-frequency variant at CCND 2 halves the risk of type 2 diabetes by enhancing insulin secretion (2015) (3)
Bisphosphonate therapy in multiple myeloma. (1996) (3)
Genetic and Functional Analyses Identify NAT2 as a Human Insulin Sensitivity Gene (2013) (3)
Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with preeclampsia. (2002) (3)
Severely Reduced White Fat Deposits without a Defect in Insulin Action in Transgenic Mice Overexpressing Spermidine/Spermine N1-Asetyltransferase (2002) (3)
Clinical profiles of post‐load glucose subgroups and their association with glycaemic traits over time: An IMI‐DIRECT study (2020) (2)
DELPHI results on the Z0 resonance parameters through its hadronic and leptonic decay modes (1990) (2)
Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells (2017) (2)
[Update on current care guideline: diabetes]. (2013) (2)
Leucine 7 to proline 7 polymorphism in the NPY gene is associated with increased carotid atherosclerosis (1999) (2)
Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B 100-only mice (2011) (2)
Proper Conditional Analysis in the Presence of Missing Data Identified Novel Independently Associated Low Frequency Variants in Nicotine Dependence Genes (2017) (2)
Single-cell dissection of obesity-exercise axis in adipose-muscle tissues (2021) (2)
Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci (2021) (2)
Insulin resistance and depression (2005) (2)
Multiparametric platform for profiling lipid trafficking in human leukocytes (2022) (2)
Genome-wide association study of 1,391 plasma metabolites in 6,136 Finnish men identifies 303 novel signals and provides biological insights into human diseases (2021) (2)
Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population (2003) (2)
Heterozygous RFX6 protein truncating variants are associated with Maturity-Onset Diabetes of the Young (MODY) with reduced penetrance (2017) (2)
Mortality fromamyloidosis andrenal diseases in patients withrheumatoid arthritis (1986) (2)
Predistortion of OFDM signals for VLC systems using phosphor-converted LEDs (2022) (2)
The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets (2022) (2)
Extent to which array genotyping and imputation with large reference panels approximate deep whole-genome sequencing. (2022) (2)
Obesity and Type 2 Diabetes (2014) (2)
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers (2020) (2)
Effects of age, amyloid, sex, and APOE ε4 on the CSF proteome in normal cognition (2022) (2)
Lack of association between early atherosclerotic carotid artery wall lesions and serum level of homocysteine (2003) (2)
Computational identification of cancer susceptibility loci. (2010) (2)
Phase-coherent multichannel SDR - Sparse array beamforming (2021) (2)
Association Analysis and Meta-Analysis of Multi-Allelic Variants for Large-Scale Sequence Data (2020) (2)
Response to Brosch et al. (2012) (2)
Decreased plasma C-reactive protein levels in APOE epsilon 4 allele carriers (2018) (2)
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids (2019) (2)
University of Groningen Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk (2011) (2)
[Metabolic control by means of insulin in patients with type 2 diabetes and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity--secondary publication]. (2006) (2)
Prevalence of Isthmic Lumbar Spondylolisthesis in Nondiabetic Subjects and NIDDM Patients (1994) (2)
Utilizing a position-sensitive wire chamber in sheet density measurements (1989) (1)
Identification of sample-specific regulations using integrative network level analysis (2015) (1)
Computational Identification of Recessive Mutations in Cancers using High Throughput SNP-arrays (2007) (1)
non-insulin-dependent diabetic patients and nondiabetic subjects High fasting plasma insulin is an indicator of coronary heart disease in (2011) (1)
Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk (2020) (1)
Association between high-sensitive measurement of C-reactive protein and metabolic syndrome as defined by International Diabetes Federation, National Cholesterol Education Program, and World Health Organization criteria in a population-base (2006) (1)
Search for Higgs bosons using the Delphi detector (1990) (1)
Evaluation of FOXFET biased ac-coupled silicon strip detector prototypes for CDF SVX upgrade (1992) (1)
A Measurement of the partial width of the Z0 boson into b quark pairs (1990) (1)
Developments in plastic wire chambers operated in the limited streamer mode (LSM detectors) (1988) (1)
Speech Related Navigation - a Challenge for Human-Computer Interaction? (2003) (1)
Modelling of the depleted p-JFET radiation detector (1992) (1)
Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. (2019) (1)
Discovery and Refinement Supplementary (2015) (1)
Abstract 1395: Risk Predictors of First Microvascular Complications in Type 2 Diabetes Mellitus: The FIELD Study (2009) (1)
Decreasing Postprandial Plasma Glucose Using an α-Glucosidase Inhibitor in Subjects with IGT for the Prevention of Type 2 Diabetes Mellitus: The STOP-NIDDM Trial (2012) (1)
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2021) (1)
A reference map of potential determinants for the human serum metabolome (2020) (1)
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution (2019) (1)
Insulin Receptor Substrate-I Variants in Non-Insulin-dependent Diabetes (2013) (1)
Circulating Meitabolite Predictors of Glycemia in Middle-Aged Men and Women (2012) (1)
immunoreactivity inthe cerebrospinal fluid ofpatients withParkinson's disease andits relation todementia (1986) (1)
Characterisation of new K-ATP-channel mutations associated with congenital hyperinsulinism in the Finnish population (vol 46, pg 241, 2003) (2004) (1)
Lipid disorders in type 2 diabetes. (2009) (1)
Mitochondrial genome copy number in human blood-derived DNA is strongly associated with insulin levels and related metabolic traits and primarily reflects cell-type composition differences (2020) (1)
FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study (2021) (1)
Physical activity and sedentary behavior; mechanistic insights and role in disease prevention (2021) (1)
Supplementary Material 15 (2013) (1)
Exome sequencing identifies high-impact trait-associated alleles enriched in Finns (2018) (1)
Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS (2018) (1)
Worthless or valuable (2013) (1)
Adipose Co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes (2012) (1)
Risk predictors of lower-limb amputation in patients with type 2 diabetes mellitus in the fenofibrate intervention and event lowering in diabetes study (2011) (1)
Transcript expression-aware annotation improves rare variant interpretation (2020) (1)
Increased urinary polyamine excretion after starting a very low calorie diet. (1993) (1)
Challenges in studies of the genetic basis of Type 2 diabetes (2007) (1)
SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice (2021) (1)
Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice (2020) (1)
Supplementary Material 4 (2015) (1)
MS546 FENOFIBRATE REDUCES PERIPHERAL NEUROPATHY IN TYPE 2 DIABETES: THE FENOFIBRATE INTERVENTION AND EVENT LOWERING IN DIABETES (FIELD) STUDY (2010) (1)
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (2020) (1)
Metabolite signature of albuminuria involves amino acid pathways in 8,661 Finnish men without diabetes. (2020) (1)
Loci for insulin processing and secretion provide insight into type 2 diabetes risk. (2023) (1)
Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior (2017) (1)
Contextual priming technique in the treatment of chronic anomia (2002) (1)
Erratum: Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology (The American Journal of Human Genetics (2019) 105(1) (15–28), (S0002929719301880), (10.1016/j.ajhg.2019.05.002)) (2019) (1)
Abstract 18987: Fenofibrate Reduces Peripheral Neuropathy in Type 2 Diabetes: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study (2010) (1)
Supplementary Material 9 (2013) (1)
Author Correction: Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes (2021) (1)
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals (2018) (1)
Large scale trans-ethnic meta-analyses identify novel rare and common variants associated with blood pressure and hypertension (2016) (1)
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity (2019) (1)
Metabolite Signature in the Carriers of Pathogenic Genetic Variants for Cardiomyopathy: A Population-Based METSIM Study (2022) (1)
Abstract 1246: Reduced Renal Function (EGFR) And Albuminuria In Type 2 Diabetes Independently Predict Cardiovascular (CVD) Events And Mortality Even In A Low Risk Cohort: The FIELD Study (2008) (1)
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort (2017) (1)
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus (2020) (1)
The Impact and Correction of Analysis Delay and Variability in Storage Temperature on the Assessment of HbA1c from Dried Blood Spots-an IMI DIRECT Study (2019) (1)
[New criteria and care for metabolic syndrome]. (2005) (1)
Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power (2019) (0)
Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes (2020) (0)
SIRT 1 expression , energy expenditure and insulin sensitivity SIRT 1 mRNA Expression May Be Associated with Energy Expenditure and Insulin Sensitivity Running title : SIRT 1 expression , energy expenditure and insulin sensitivity (2010) (0)
[Autosomal dominant polycystic kidney disease]. (2006) (0)
[Congenital hyperinsulinism]. (2020) (0)
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls (2019) (0)
Molecular characterization of the lipid GWAS signal on chromosome 18q11.2 implicates HNF4A-mediated regulation of the TMEM241 gene (2016) (0)
An intronic variant in the GCKR gene is associated with multiple lipids (2019) (0)
[Clodronate and myeloma]. (1995) (0)
25-OR: Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus (2019) (0)
Moksiskaan Analysis of the Candidate Genes (2013) (0)
The QT-interval prolonging variant p.D85N of KCNE1 associates with reduced levels of insulin after an oral glucose load (2014) (0)
Club 35 Poster Session Thursday 6 December: Intracardiac flows and pressures (2012) (0)
Reply (1990) (0)
SUN-657 The Effect of Simvastatin on Glucose Metabolism in Primary Human Muscle Cells (2020) (0)
Does the quality of routine clinical care influence the metabolic control and outcome of diabetic patients? Society of General Internal Medicine, 17th Annual Meeting, Washington DC, April 27-29, 1994. (1994) (0)
Meta-analyzed single SNP interactions with physical activity* on BMI. (2013) (0)
A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors (2017) (0)
Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes (2021) (0)
5 REDUCED HEXOKINASE II IMPAIRS MUSCLE FUNCTION TWO WEEKS AFTER ISCHEMIA-REPERFUSION THROUGH INCREASED CELL NECROSIS AND FIBROSIS (2012) (0)
Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia (2018) (0)
Molecular and Cellular Pathobiology FoxA 1 Speci fi es Unique Androgen and Glucocorticoid Receptor Binding Events in Prostate Cancer Cells (2013) (0)
Clinical and Genetic Characterization of 148 Patients with Persistent or Transient Congenital Hyperinsulinism: A Population-Based Study in Finns (2019) (0)
Long-range chromosomal interactions increase and mark repressed gene expression during adipogenesis (2022) (0)
Heterogeneity of LDL uptake responses in individual hypercholesterolemia patients (2020) (0)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (0)
[Not Available]. (2006) (0)
The association between diabetes and Alzheimer’s disease pathophysiology (2021) (0)
Abstract: 537 CHOLESTEROL METABOLISM IN RELATION TO GLUCOSE TOLERANCE IN A LARGE FINNISH MALE POPULATION (2009) (0)
Title : Six new loci associated with body mass index highlight a neuronal influence on body weight regulation (0)
Preface to the Special Section Diabetes and Atherosclerosis (1996) (0)
Abstract MP63: Fine-mapping and Characterization of Adiponectin Gwas Loci Harboring Extensive Allelic Heterogeneity (2018) (0)
' s response to reviews Title : Adipose Transcript Networks Across Finns and Mexicans Identify Novel Triglyceride-Associated Genes (2012) (0)
Prevention of Cardiovascular Events in Diabetic Patients (2008) (0)
Contents Vol. 22, 2006 (2006) (0)
Multiparametric profiling of cellular lipid metabolism in hypercholesterolemia (2021) (0)
Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment (2022) (0)
[Acarbose--an effective drug for the prevention of type 2 diabetes and cardiovascular diseases?]. (2003) (0)
Lifestyle and environmental interactions in type 2 diabetes (2002) (0)
107 Betaxolol has no adverse effects on insulin sensitivity in patients with essential hypertension (1993) (0)
The mutational constraint spectrum quantified from variation in 141,456 humans (2020) (0)
Abstract 18865: Novel Cardiovascular Risk Factor Prediction of Cardiovascular Events in the (Type 2 Diabetes) FIELD Study and Effects of Fenofibrate (2010) (0)
[Sarcomere gene mutations--a cause of hypertrophic cardiomyopathy]. (1999) (0)
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative (2018) (0)
Physical Activity and Impaired Glucose Tolerance in Obesity (2015) (0)
Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes (2021) (0)
1845-P: Divergent Effects on T2D of Alleles Associated with Increased Liver Fat Reflect Differential Impact on Hepatic Glucose and Lipid Output: An IMI DIRECT Study (2019) (0)
Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum (2017) (0)
Author Correction: Evaluating drug targets through human loss-of-function genetic variation (2021) (0)
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition (2018) (0)
Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes (2022) (0)
The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis (2011) (0)
W14.361 Polymorphism in the ABCG5 and ABCG8 genes and cholesterol and glucose metabolism in mild hypercholesterolemia (2004) (0)
P5361Novel biomarkers predict congestive heart failure in 10,106 finnish men (2018) (0)
Evaluating drug targets through human loss-of-function genetic variation (2020) (0)
A catalog of genetic loci associated with kidney function from analyses of a million individuals (2019) (0)
The role of mitochondrial hexokinase II in ischemia-reperfusion damage (2012) (0)
Lipid loci with multiple signals in Europeans. (2013) (0)
Quantitative genetic analysis of lipoproteins in Finnish hyperlipidemic families (2001) (0)
Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS (2018) (0)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (0)
Contents Vol. 19, 2000 (2000) (0)
S u l f o n y l u rea Receptor 1 Gene Va r i a n t s A re Associated With Gestational Diabetes and Type 2 Diabetes but Not With Altered Secretion of Insulin (2000) (0)
Brain microvasculaure in ageing and dementia (2001) (0)
protein ( TXNIP ) gene by hyperglycemia in Epigenetic regulation of the thioredoxin-interacting kidney (0)
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (0)
Abstract 13621: Stroke in People with Impaired Glucose Tolerance (2011) (0)
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study (2020) (0)
Impact of the ALA55VAL polymorphism of the UCP2 gene on weight reduction and BMR (1998) (0)
[Glucose metabolism disorders following an acute alcoholic pancreatitis]. (1998) (0)
1.P.260 Candidate gene analysis in familial combined hyperlipidemia (1997) (0)
[Chlorpropamide and the alcohol flush reaction and coronary artery disease in adult diabetics]. (1984) (0)
SARS-CoV-2 infection of human neurons requires endosomal cell entry and can be blocked by inhibitors of host phosphoinositol-5 kinase (2022) (0)
Polymophisms of thte SUR1(ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes (2004) (0)
Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells (2017) (0)
Adventitial gene transfer to rabbit carotid arteries (1997) (0)
Lipid dosorders in type 2 diabetes (2009) (0)
Data integration to prioritize drugs using genomics and curated data (2016) (0)
Reverse gene–environment interaction approach to identify variants influencing body-mass index in humans (2019) (0)
Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts (2023) (0)
2.W12.5 Adventitial gene transfer to rabbit carotid arteries (1997) (0)
[Determination of C-peptide in the choice of treatment for diabetics]. (1983) (0)
ERRATUM: Simvastatin profoundly impairs energy metabolism in primary human muscle cells (2022) (0)
P4663Hyperinsulinemia, hypertension and two clusters of biomarkers predict aortic stenosis in 10,144 Finnish men (2019) (0)
The Heavy Burden of Cardiovascular Disease in Type 2 Diabetes (2003) (0)
[From injections to pills--neonatally diagnosed diabetes of mother and baby]. (2011) (0)
Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes (2021) (0)
Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity (2020) (0)
Radionuclide image in chronic heart failureOral abstract sessionCharacterisation of cardiac phenotype in genetically defined hypertrophic cardiomyopathy (2005) (0)
CARDIAC ISCHEMIA‐REPERFUSION DAMAGE IN PARTIAL HEXOKINASE (HK) II KNOCKOUT MICE (2007) (0)
Author Correction: Transcript expression-aware annotation improves rare variant interpretation (2021) (0)
Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study (2020) (0)
[Not Available]. (2007) (0)
Markku Laakso the UK Prospective Diabetes Study Benefits of Strict Glucose and Blood Pressure Control in Type 2 Diabetes : Lessons From (1999) (0)
Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance (2017) (0)
Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (2017) (0)
DrFARM: Identification and inference for pleiotropic gene in GWAS (2022) (0)
Response to Letter by Sheikh (2008) (0)
A multi-ancestry genome-wide meta-analysis, fine-mapping, and target gene prioritization to characterize the genetic architecture of adiponectin. (2023) (0)
Polymorphism at codon 54 of the fatty acid binding protein 2 is associated with postprandial lipemic response (1998) (0)
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps (2018) (0)
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2020) (0)
A structural variation reference for medical and population genetics (2020) (0)
[Not Available]. (2007) (0)
[Glucokinase: the first hit in the hunt for a gene in late-onset diabetes]. (1994) (0)
Annotation (1953) (0)
Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition (2018) (0)
Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice (2020) (0)
Reconstructing the Metabolic Network of a Bacterium from Its Genome (2007) (0)
Subject Index Vol. 22, 2006 (2006) (0)
69 Candidate genes in non-insulin-dependent diabetes mellitus (1997) (0)
rheumatoid arthritis . renal diseases in patients with Mortality from amyloidosis and (0)
The relative importance of cardiovascular risk factors in type 2 diabetes (2004) (0)
Phenotypic characterization of seven genetic variants associated with non-alcoholic fatty liver disease (2020) (0)
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2018) (0)
Plasma lipids and lipoproteins in diabetes: lessons from population-based studies. (1990) (0)
Investigation of multiple dyslipidemias in a large Austrian pedigree by genetic risk scores and exome sequencing (2016) (0)
Sex‐Specific Genetic Regulation of Adipose Mitochondria and Their Relationship to Metabolic Syndrome (2021) (0)
Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study (2020) (0)
Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial (2015) (0)
Edinburgh Research Explorer Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes (2018) (0)
Dominantly inherited form of hyperinsulinism caused by a gene mutation in the sulfonylurea receptor 1 (2000) (0)
Carriers of an inactivating beta-cell K-ATP channel mutation have normally regulated insulin secretion (2000) (0)
Abstract: 49 CROSS-SPECIES COMPARISONS OF GWAS DATA AS A SCREENING TOOL TO IDENTIFY NOVEL LOCI FOR LDL-C (2009) (0)
Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications (2023) (0)
Risk factors for fatal and non-fatal cardiovascular events in 9306 subjects in the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial (2011) (0)
[Not Available]. (2007) (0)
[Not Available]. (2007) (0)
Lifestyle Intervention: A Whole-Body Magnetic Resonance Study Determine the Change in Body Composition during PPARD Variations in (2008) (0)
[Update on Current Care Guideline. Diabetes]. (2016) (0)
Antiplatelet drugs in secondary prevention of stroke, lessons from the European Stroke Prevention Studies 1 and 2 (1997) (0)
Radionuclide image in chronic heart failure oral abstract session (2005) (0)
Natural history of type 2 diabetes and macrovascular disease (2009) (0)
University of Dundee Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes Koivula, (2014) (0)
Epigenome-wide association in adipose tissue from the METSIM cohort identifies novel loci and the involvement of adipocytes and macrophages in diabetes traits (2017) (0)
Multiparametric Platform for Profiling Lipid Trafficking in Human Leukocytes: Application for Hypercholesterolemia (2021) (0)
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2019) (0)
Abstract 10916: Mendelian Randomization Studies Do Not Support a Causal Effect of Plasma Lipids on Insulin Sensitivity (2012) (0)
3 REDUCTION IN HEXOKINASE II LEVELS RESULTS IN DECREASED CARDIAC FUNCTION AND ALTERED REMODELING AFTER ISCHEMIA-REPERFUSION INJURY (2012) (0)
Retraction Notice to: The Cancer-Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes. (2020) (0)
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology (2017) (0)
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models (2023) (0)
Abstract MP62: Fatty Acid Biomarkers of 15:0, 17:0 and Trans 16:1n-7 and Incident Coronary Heart Disease and Stroke: A Pooling Project of 15 Prospective Cohorts in the Fatty Acids and Outcomes Research Consortium (2023) (0)
Plasma Metabolite Signatures in Male Carriers of Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease (2023) (0)
Mapping and characterization of structural variation in 17,795 human genomes (2020) (0)
Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL 8 HDLC GWAS Locus Cannon (0)
Abstract A57: Nonsense‐mediated decay escaping mutations in microsatellite-unstable colorectal cancer (2009) (0)
Genome-Wide Association Identi ﬁ es Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes (2011) (0)
Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans (2021) (0)
Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences (2021) (0)
Family with the rare GLA-Thr410Ala mutation (2020) (0)
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene - eScholarship (2015) (0)
Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance (2022) (0)
Genetic Engineering of Polyamine Catabolism in Transgenic Mice and Rats (2006) (0)
Lifestyle Intervention Guided by Group and Internet-Based Counseling in the T2D-GENE Trial Supports Its Applicability and Feasibility (2023) (0)
Circulating follistatin predicts type 2 diabetes risk (2020) (0)
[Coronary heart disease morbidity in NIDDM]. (1996) (0)
A method for screening therapeutic compounds of diabetic (2004) (0)
Rheumatoid arthritis and mortality. (1986) (0)
Lipids and Glucose in Type 2 Diabetes: What About the β-Cell and the Mitochondria? Response to Eldor and Raz (2005) (0)
PO11-294 A NEW MOUSE MODEL OF DIABETIC ATHEROSCLEROSIS REVEALS INCREASED LESION COMPLEXITY AND CALCIFICATION WITHOUT WORSENING OF HYPERCHOLESTEROLEMIA (2007) (0)
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (2021) (0)
Mutations in the PPARγ Gene Relevant for Diabetes and the Metabolic Syndrome (2006) (0)
Oxidised LDL and progression of atherosclerosis (Letter to the Editor) (1992) (0)
Prevalence of diabetes mellitus in elderly subjects in east Finland (1987) (0)
Edinburgh Research Explorer Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (2018) (0)
Impact of the 19 Known Genetic Risk Variants on the Incidence of Diabetes in the Finnish Diabetes Prevention Study (2010) (0)
The effect of LRRK2 loss-of-function variants in humans (2020) (0)
Erratum to: Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes (2009) (0)
Tu-P7:44 Mouse model of diabetic atherosclerosis- characterization and applications in vascular research (2006) (0)
Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide (2021) (0)
Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes (2022) (0)
Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes (2022) (0)
factors in multiple myeloma. Finnish Leukemia Group Immunoreactive interleukin-6 and acute phase proteins as prognostic (2011) (0)
Contribution of genetic and dietary insulin resistance to Alzheimer’s phenotype in APP/PS1 transgenic mice (2011) (0)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (0)
The FADS1 genotypes modify the effect of linoleic acid-enriched diet on adipose tissue inflammation via pro-inflammatory eicosanoid metabolism (2022) (0)
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase (2023) (0)
Author Correction: A structural variation reference for medical and population genetics (2021) (0)
Protective effect of the pro12Ala variant of the human peroxisome proliferator activated receptor γ2 on obesity, insulin sensitivity and glucose tolerance (2000) (0)
Partial Hexokinase II Deficiency Does Not Accelerate the Formation of Diet-Induced Atherosclerotic Lesions in LDL Receptor Null Mice (2002) (0)
Rendering with Coherent Layers (2004) (0)
Near-field localization using machine learning: an empirical study (2021) (0)
Search for nonstandard Z0 decays in two particle final states (1990) (0)
Charged multiplicity and rapidity distributions in Z0 hadronic decays (1990) (0)
Navigation and Object Manipulation in Collaborative VR Interior Design (2012) (0)
Open-Source Demo System to Support Automated Identification and Tracking Workshops (2007) (0)
Radiation damage measurements on double-sided Si strip detectors (1991) (0)
Search for pair production of neutral Higgs bosons in Z ° decays (2002) (0)
Empirical evaluation of OFDM waveforms for VLC in the presence of LED nonlinearities (2021) (0)
Metabolomic Profiling Identifies Biomarkers Associated with Dysglycemia and Incident Type 2 Diabetes in the METSIM Study (2013) (0)
Stereoscopic display in a slot machine (2012) (0)
Foerfarande and an arrangement of maetning of pappersformation. (1988) (0)
[Drug therapy of hyperglycemia and the prognosis of adult-onset diabetes mellitus]. (1999) (0)
4.P.355 Decreased antilipolytic effect of insulin is associated with low glucose oxidation rate and dyslipidemias in familial combined hyperlipidemia (1997) (0)
Insulin resistance is associated with hypertriglyceridemia and combined hyperlipidemia but not with hypercholesterolemia in familial combined hyperlipidemia (1999) (0)
Dietary fat intake and coronary heart disease events in subjects with type 2 diabetes (2000) (0)
Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion (2023) (0)
Left ventricular dysfunction in diabetes: evidence for the impact of metabolic factors (1987) (0)
risk of developing type 2 diabetes (SUR1) genes on the ABCC8 (GLUT2) and SLC2A2activity modifies the effect of SNPs in the (2015) (0)
The A→G polymorphism in the 5′-flanking domain of the uncoupling protein 1 gene is associated with enhanced weight loss in obese finns (1998) (0)
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS (2018) (0)
Leptin Concentrations, Sex Hormones, and Cortisol in Nondiabetic Men—Authors’ Response (1998) (0)
Small low density lipoprotein particles in familial combined hyperlipidemia (2000) (0)
Intima-media thickness and atherosclerotic plaques in popliteal, tibial, brachial and radial arteries in 65-year-old Finns with diabetes (2005) (0)
Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study (2021) (0)
Systematic use of computational methods allows stratification of treatment responders in glioblastoma multiforme (2013) (0)
The Distribution of Power in the Scandinavian Parliaments (1981) (0)
Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (2021) (0)
Short running title: GIPR, adipose tissue and insulin resistance (2013) (0)
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are AssociatedWith Incident Type 2 Diabetes (2017) (0)
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes (2020) (0)
Subject Index Vol. 19, 2000 (2000) (0)
Echocardiographic parameters for the study subjects. (2015) (0)

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