Markus Zweckstetter

Markus Zweckstetter's AcademicInfluence.com Rankings

Markus Zweckstetter

Physics

#6709

World Rank

#8688

Historical Rank

Biophysics

#281

World Rank

#292

Historical Rank

physics Degrees

Markus Zweckstetter

Biology

#11341

World Rank

#14729

Historical Rank

Neuroscience

#1832

World Rank

#1888

Historical Rank

biology Degrees

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Physics
Biology

Markus Zweckstetter's Degrees

PhD Biophysics University of Göttingen
Masters Physics University of Göttingen

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Markus Zweckstetter's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. (2005) (680)
VDAC, a multi-functional mitochondrial protein regulating cell life and death. (2010) (599)
Structural Polymorphism of 441-Residue Tau at Single Residue Resolution (2009) (525)
Structure of the human voltage-dependent anion channel (2008) (501)
Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau (2017) (421)
Pre‐fibrillar α‐synuclein variants with impaired β‐structure increase neurotoxicity in Parkinson's disease models (2009) (374)
RNA polymerase II clustering through carboxy-terminal domain phase separation (2018) (368)
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers (2015) (345)
Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease. (2005) (344)
NMR: prediction of molecular alignment from structure using the PALES software (2008) (331)
Structural Ensembles of Intrinsically Disordered Proteins Depend Strongly on Force Field: A Comparison to Experiment. (2015) (319)
Mars - robust automatic backbone assignment of proteins (2004) (313)
Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein* (2008) (313)
Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement. (2006) (295)
Sites of Tau Important for Aggregation Populate β-Structure and Bind to Microtubules and Polyanions* (2005) (275)
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease (2013) (274)
Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions (2010) (261)
NMR characterization of long-range order in intrinsically disordered proteins. (2010) (259)
Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action (2014) (237)
NMR of α‐synuclein–polyamine complexes elucidates the mechanism and kinetics of induced aggregation (2004) (230)
Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy. (2014) (222)
Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings. (2005) (216)
Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates (2020) (210)
Phosphorylation of Synucleins by Members of the Polo-like Kinase Family* (2009) (210)
Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. (2007) (206)
Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand (2014) (206)
Structure of the IGF‐binding domain of the insulin‐like growth factor‐binding protein‐5 (IGFBP‐5): implications for IGF and IGF‐I receptor interactions (1998) (187)
Extracellular phosphorylation of the amyloid β‐peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease (2011) (175)
Sumoylation inhibits α-synuclein aggregation and toxicity (2011) (174)
Structural properties of pore-forming oligomers of alpha-synuclein. (2009) (172)
NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA (2006) (171)
Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings. (2009) (170)
β-Sheet core of tau paired helical filaments revealed by solid-state NMR. (2012) (165)
Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering. (2014) (165)
Myelin Membrane Assembly Is Driven by a Phase Transition of Myelin Basic Proteins Into a Cohesive Protein Meshwork (2013) (161)
Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation* (2005) (161)
Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation. (2008) (157)
The “Jaws” of the Tau-Microtubule Interaction* (2007) (155)
N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits (2013) (146)
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease (2017) (137)
Glycation potentiates &agr;-synuclein-associated neurodegeneration in synucleinopathies (2017) (136)
Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules. (2009) (129)
Automatic assignment of the intrinsically disordered protein Tau with 441-residues. (2010) (127)
A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA. (2008) (126)
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation (2015) (126)
Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation. (2013) (124)
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts (2019) (123)
Characterization of molecular alignment in aqueous suspensions of Pf1 bacteriophage (2001) (122)
Entacapone and Tolcapone, Two Catechol O-Methyltransferase Inhibitors, Block Fibril Formation of α-Synuclein and β-Amyloid and Protect against Amyloid-induced Toxicity* (2010) (122)
Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution. (2012) (115)
Nuclear localization and phosphorylation modulate pathological effects of alpha‐synuclein (2018) (112)
Lysine/RNA-interactions drive and regulate biomolecular condensation (2019) (112)
Folding of the Tau Protein on Microtubules. (2015) (112)
Evaluation of uncertainty in alignment tensors obtained from dipolar couplings (2002) (110)
Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein. (2010) (109)
Structural characterization of α‐synuclein in an aggregation prone state (2009) (105)
The NMR Structure of the Sensory Domain of the Membranous Two-component Fumarate Sensor (Histidine Protein Kinase) DcuS of Escherichia coli* (2003) (100)
Imbalance of Hsp70 family variants fosters tau accumulation (2013) (100)
Prediction of charge-induced molecular alignment of biomolecules dissolved in dilute liquid-crystalline phases. (2004) (98)
Intrinsically Disordered Proteins: From Sequence and Conformational Properties toward Drug Discovery (2012) (98)
Phosphorylation drives a dynamic switch in serine/arginine-rich proteins. (2013) (96)
Measurement of long range H,C couplings in natural products in orienting media: a tool for structure elucidation of natural products. (2003) (93)
Structural characterization of the intrinsically unfolded protein β-synuclein, a natural negative regulator of α-synuclein aggregation (2007) (92)
Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease (2016) (91)
Structural and mechanistic basis behind the inhibitory interaction of PcTS on α-synuclein amyloid fibril formation (2009) (91)
Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons (2011) (91)
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau (2017) (88)
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation (2014) (87)
Effect of zinc binding on β-amyloid structure and dynamics: implications for Aβ aggregation. (2011) (86)
Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation. (2005) (85)
Conkunitzin-S1 Is the First Member of a New Kunitz-type Neurotoxin Family (2005) (85)
Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors with Distinct Mechanisms of Action* (2010) (84)
Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation (2018) (82)
Structural characterization of binding of Cu(II) to tau protein. (2008) (81)
Structural Impact of Tau Phosphorylation at Threonine 231. (2015) (81)
Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity (2016) (80)
The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain‐like fold (2001) (80)
α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner (2014) (79)
Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. (2011) (77)
The dynamic structure of filamentous tau. (2011) (76)
Exploring the structural details of Cu(I) binding to α-synuclein by NMR spectroscopy. (2011) (71)
Long-range correlated dynamics in intrinsically disordered proteins. (2014) (71)
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity (2016) (70)
Aggregate Clearance of α-Synuclein in Saccharomyces cerevisiae Depends More on Autophagosome and Vacuole Function Than on the Proteasome* (2012) (70)
β‐synuclein aggregates and induces neurodegeneration in dopaminergic neurons (2013) (69)
Targeting intrinsically disordered proteins in rational drug discovery (2016) (68)
Phosphorylation modifies the molecular stability of β-amyloid deposits (2016) (68)
Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease. (2014) (67)
Lost in translocation: the functions of the 18-kD translocator protein (2015) (64)
Structural and microtubule binding properties of tau mutants of frontotemporal dementias. (2007) (64)
Single-step determination of protein substructures using dipolar couplings: aid to structural genomics. (2001) (64)
Mitogen‐activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment (2006) (64)
Inhibition of tau filament formation by conformational modulation. (2013) (63)
Correlation of Amyloid Fibril β‐Structure with the Unfolded State of α‐Synuclein (2007) (62)
Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure (2017) (62)
Amino acid bulkiness defines the local conformations and dynamics of natively unfolded alpha-synuclein and tau. (2007) (61)
The Nature of the Stimulus and of the Fumarate Binding Site of the Fumarate Sensor DcuS of Escherichia coli* (2005) (61)
The native conformation of the human VDAC1 N terminus. (2010) (59)
Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2. (2013) (59)
Methylation of Lysine 9 in Histone H3 Directs Alternative Modes of Highly Dynamic Interaction of Heterochromatin Protein hHP1β with the Nucleosome* (2012) (58)
Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo* (2015) (57)
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. (2009) (57)
Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site (1998) (56)
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology (2017) (56)
Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding. (2015) (54)
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex (2018) (53)
Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation* (2012) (50)
Is enantiomer assignment possible by NMR spectroscopy using residual dipolar couplings from chiral nonracemic alignment media?--A critical assessment. (2012) (48)
The intermembrane space domain of Tim23 is intrinsically disordered with a distinct binding region for presequences (2010) (45)
Molten globule precursor states are conformationally correlated to amyloid fibrils of human beta-2-microglobulin. (2010) (45)
The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor. (2008) (44)
Structure of the active domain of the herpes simplex virus protein ICP47 in water/sodium dodecyl sulfate solution determined by nuclear magnetic resonance spectroscopy. (1999) (44)
The PIP2 binding mode of the C2 domains of rabphilin‐3A (2008) (43)
Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells* (2015) (42)
Backbone assignment of proteins with known structure using residual dipolar couplings (2004) (42)
Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90 (2017) (42)
Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation. (2007) (42)
Rapid and accurate structure determination of coiled‐coil domains using NMR dipolar couplings: Application to cGMP‐dependent protein kinase Iα (2005) (42)
An adiabatic multiple spin-echo pulse sequence: removal of systematic errors due to pulse imperfections and off-resonance effects. (1998) (42)
Interaction between Amyloid Beta Peptide and an Aggregation Blocker Peptide Mimicking Islet Amyloid Polypeptide (2011) (41)
Structure and DNA‐binding properties of the cytolysin regulator CylR2 from Enterococcus faecalis (2004) (40)
Conserved core of amyloid fibrils of wild type and A30P mutant α‐synuclein (2011) (40)
Toward the Discovery of Effective Polycyclic Inhibitors of α-Synuclein Amyloid Assembly* (2011) (40)
Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease (2021) (40)
Human cyclophilin 40 unravels neurotoxic amyloids (2017) (39)
Turn plasticity distinguishes different modes of amyloid-β aggregation. (2014) (39)
Structural Properties of Pore-Forming Oligomers of r-Synuclein (2009) (39)
Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism (2019) (39)
Pre-Fibrillar α-Synuclein Mutants Cause Parkinson's Disease-Like Non-Motor Symptoms in Drosophila (2011) (38)
High-Resolution 3D Structure Determination of Kaliotoxin by Solid-State NMR Spectroscopy (2008) (38)
Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates (2020) (37)
Endogenous Oligodendroglial Alpha-Synuclein and TPPP/p25α Orchestrate Alpha-Synuclein Pathology in Experimental Multiple System Atrophy Models (2019) (37)
Cold denaturation of a protein dimer monitored at atomic resolution. (2013) (37)
Conversion of the Kunitz-type module of collagen VI into a highly active trypsin inhibitor by site-directed mutagenesis. (1996) (35)
Structural Determinants for Ca2+ and Phosphatidylinositol 4,5-Bisphosphate Binding by the C2A Domain of Rabphilin-3A* (2008) (34)
Local and Global Dynamics in Intrinsically Disordered Synuclein. (2018) (34)
Simultaneous assignment and structure determination of protein backbones by using NMR dipolar couplings. (2004) (33)
Dissociation of amyloid fibrils of alpha-synuclein in supercooled water. (2008) (33)
A Novel SNCA A30G Mutation Causes Familial Parkinsonʼs Disease (2021) (33)
Structure and Functions of Microtubule Associated Proteins Tau and MAP2c: Similarities and Differences (2019) (33)
Structural Integrity of the A147T Polymorph of Mammalian TSPO (2015) (32)
Prion Protein Helix1 Promotes Aggregation but Is Not Converted into β-Sheet* (2006) (31)
Molecular Plasticity of the Human Voltage-Dependent Anion Channel Embedded Into a Membrane. (2016) (31)
Capture of Dense Core Vesicles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4 (2017) (30)
Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity. (2016) (30)
The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease. (2018) (29)
Nucleotide Interactions of the Human Voltage-dependent Anion Channel* (2014) (29)
High-resolution structure determination of the CylR2 homodimer using paramagnetic relaxation enhancement and structure-based prediction of molecular alignment (2007) (29)
Predicting the rotational tumbling of dynamic multidomain proteins and supramolecular complexes. (2013) (28)
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol (2019) (28)
Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1 (2016) (27)
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization (2020) (26)
Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease (2021) (26)
High‐Resolution NMR Determination of the Dynamic Structure of Membrane Proteins (2016) (26)
Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2 (2015) (26)
Structure of the mammalian TSPO/PBR protein. (2015) (26)
The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology (2011) (26)
Structure and multiple conformations of the kunitz-type domain from human type VI collagen alpha3(VI) chain in solution. (1996) (25)
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. (2015) (24)
Prion protein helix1 promotes aggregation but is not converted into beta-sheet. (2006) (24)
Production of recombinant Conkunitzin-S1 in Escherichia coli. (2006) (24)
Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex (2014) (24)
Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer (2016) (23)
Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils (2021) (23)
Molecular basis of the dynamic structure of the TIM23 complex in the mitochondrial intermembrane space. (2014) (23)
Structure, gating and interactions of the voltage-dependent anion channel (2021) (22)
Integrated analysis of the conformation of a protein-linked spin label by crystallography, EPR and NMR spectroscopy (2011) (22)
Conformational Flexibility in the Transmembrane Protein TSPO. (2015) (22)
Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure (2021) (21)
Molecular Basis of Small-Molecule Binding to α-Synuclein (2021) (21)
Phosphorylation Interferes with Maturation of Amyloid-β Fibrillar Structure in the N Terminus* (2016) (21)
NMR hawk‐eyed view of AlphaFold2 structures (2021) (21)
Bioinorganic chemistry of synucleinopathies: deciphering the binding features of Met motifs and His-50 in AS-Cu(I) interactions. (2014) (20)
Structural Plasticity in Human Heterochromatin Protein 1β (2013) (20)
Interplay between tau and α-synuclein LLPS. (2021) (20)
Pathophysiological Consequences of Neuronal α-Synuclein Overexpression: Impacts on Ion Homeostasis, Stress Signaling, Mitochondrial Integrity, and Electrical Activity (2018) (19)
Biomolecular condensation of the microtubule-associated protein tau. (2020) (19)
Burial of the Polymorphic Residue 129 in Amyloid Fibrils of Prion Stop Mutants* (2012) (19)
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution (2020) (19)
Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry (2022) (19)
Multiple paramagnetic effects through a tagged reporter protein. (2015) (18)
Conkunitzin-S 1 Is the First Member of a New Kunitz-type Neurotoxin Family STRUCTURAL AND FUNCTIONAL CHARACTERIZATION * (2005) (18)
The binding mode of a repeat-like Tau sequence with tubulin (2017) (18)
Amyloidogenic potential of alpha-chymotrypsin in different conformational states. (2009) (18)
Charge-induced molecular alignment of intrinsically disordered proteins. (2006) (18)
Upregulated levels and pathological aggregation of abnormally phosphorylated Tau-protein in children with neurodevelopmental disorders (2019) (17)
The Molecular Basis of the Interaction of Cyclophilin A with α‐Synuclein (2019) (16)
Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view (2018) (16)
The Binding Mode of a Tau Peptide with Tubulin. (2018) (16)
Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2 (2020) (16)
Determination of molecular alignment tensors without backbone resonance assignment: Aid to rapid analysis of protein-protein interactions (2003) (16)
The C2A-C2B Linker Defines the High Affinity Ca2+ Binding Mode of Rabphilin-3A* (2007) (16)
Fast high-resolution protein structure determination by using unassigned NMR data. (2007) (16)
Interaction of the Intermembrane Space Domain of Tim23 Protein with Mitochondrial Membranes* (2014) (15)
Structure of Monomeric Transthyretin Carrying the Clinically Important T119M Mutation. (2016) (15)
A six-dimensional alpha proton detection-based APSY experiment for backbone assignment of intrinsically disordered proteins (2014) (15)
In response to: The validity of 18F-GE180 as a TSPO imaging agent (2019) (15)
NMR in the SPINE Structural Proteomics project. (2006) (15)
Determination of amyloid core structure using chemical shifts (2012) (15)
RNA polymerase II clustering through CTD phase separation (2018) (14)
Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure. (2017) (14)
Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics (2018) (14)
Interplay between tau and α‐synuclein liquid–liquid phase separation (2021) (14)
Elucidating the structure of an infectious protein (2017) (14)
Simultaneous measurement of protein one-bond residual dipolar couplings without increased resonance overlap. (2005) (14)
N-H spin-spin couplings: probing hydrogen bonds in proteins. (2013) (14)
Residue-specific identification of liquid phase separation hot spots of the Alzheimer’s disease-related protein Tau (2019) (14)
Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00531e (2019) (14)
Dynamic Aha1 co‐chaperone binding to human Hsp90 (2019) (13)
Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war (2020) (12)
Determination of Complex Small‐Molecule Structures Using Molecular Alignment Simulation (2020) (12)
Robust refocusing of 13C magnetization in multidimensional NMR experiments by adiabatic fast passage pulses (1999) (12)
Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1β (2014) (12)
Rapid and accurate structure determination of coiled-coil domains using NMR dipolar couplings: application to cGMP-dependent protein kinase Ialpha. (2005) (12)
Reorientational Dynamics of Amyloid-β from NMR Spin Relaxation and Molecular Simulation (2019) (12)
Insights into Cholesterol/Membrane Protein Interactions Using Paramagnetic Solid-State NMR. (2018) (11)
Prediction of charge-induced molecular alignment: residual dipolar couplings at pH 3 and alignment in surfactant liquid crystalline phases (2005) (11)
Retention and splicing complex (RES) – the importance of cooperativity (2015) (11)
Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket (2012) (11)
Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity (2021) (11)
Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils (2020) (10)
Determination of the packing mode of the coiled-coil domain of cGMP-dependent protein kinase Ialpha in solution using charge-predicted dipolar couplings. (2005) (10)
Assignment‐free solution NMR method reveals CesT as an unswapped homodimer (2008) (10)
Conserved amyloid core structure of stop mutants of the human prion protein (2013) (10)
Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop (2020) (10)
Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding (2022) (10)
Structural Determinants for Ca 2 and Phosphatidylinositol 4 , 5-Bisphosphate Binding by the C 2 A Domain of Rabphilin-3 A * (2008) (10)
Cold-Induced Changes in the Protein Ubiquitin (2012) (9)
Bioinorganic Chemistry of Parkinson's Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein. (2017) (9)
Towards a consensus on developmental regression (2019) (9)
Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand (2016) (8)
Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features. (2018) (8)
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity (2022) (8)
Internalization routes of cell‐penetrating melanoma antigen peptides into human dendritic cells (2014) (8)
HYCUD: a computational tool for prediction of effective rotational correlation time in flexible proteins (2015) (8)
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease (2017) (7)
α-Synuclein polymorphism determines oligodendroglial dysfunction (2021) (7)
Toward the functional oligomerization state of tryptophan‐rich sensory proteins (2014) (7)
Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. (2019) (7)
Solid‐Phase Synthesis and Characterization of N‐Terminally Elongated Aβ−3–x‐Peptides (2016) (6)
Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis (2020) (6)
The PIP 2 binding mode of the C 2 domains of rabphilin-3 A (6)
Potent Tau Aggregation Inhibitor D‐Peptides Selected against Tau‐Repeat 2 Using Mirror Image Phage Display (2021) (6)
Expression, purification, crystallization and preliminary crystallographic studies of the Enterococcus faecalis cytolysin repressor CylR2. (2004) (6)
Solid-phase fluorescent BODIPY–peptide synthesis via in situ dipyrrin construction† (2020) (5)
Structure and Functions of Microtubule Associated Proteins Tau and MAP 2 c : Similarities and Differences (2019) (5)
Structures of intermediates during RES complex assembly (2015) (5)
Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis (2021) (5)
A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro (2022) (5)
Brain iron enrichment attenuates α‐synuclein spreading after injection of preformed fibrils (2021) (5)
Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein (2022) (4)
The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure (2021) (4)
Membrane-embedded TSPO: an NMR view (2020) (4)
Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations (2022) (4)
Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98 (2022) (4)
Improved validation of IDP ensembles by one-bond Cα–Hα scalar couplings (2015) (4)
Structural Flexibility of Cyclosporine A Is Mediated by Amide Cis-Trans Isomerization and the Chameleonic Roles of Calcium. (2021) (4)
NMR-Based Detection of Hydrogen/Deuterium Exchange in Liposome-Embedded Membrane Proteins (2014) (4)
Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein (2021) (4)
A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity (2021) (3)
Extending the applicability of P3D for structure determination of small molecules (2020) (3)
Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells (2021) (3)
Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer’s disease from bioptic olfactory mucosa (2018) (3)
Sensory domain of the membraneous two-component fumarate sensor DcuS of E. coli (2003) (3)
The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein (2016) (3)
Molecular interactions of FG nucleoporin repeats at high resolution (2022) (3)
Detection of a transient intramolecular hydrogen bond using (1)JNH scalar couplings. (2014) (3)
Folding of Tau on microtubules. (2015) (2)
Hsp multichaperone complex buffers pathologically modified Tau (2022) (2)
Methylation of K 9 in histone H 3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP 1 β with the nucleosome (2012) (2)
Phase separation of the microtubule-associated protein tau. (2022) (2)
Titelbild: Dissociation of Amyloid Fibrils of α‐Synuclein in Supercooled Water (Angew. Chem. 27/2008) (2008) (2)
Structural Determinants for Ca 2 and Phosphatidylinositol 4,5-Bisphosphate Binding by the C2A Domain (2008) (2)
Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis (2020) (2)
Causal therapy of Parkinson's disease with anle138b, a novel protein aggregation inhibitor. (2011) (2)
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau (2017) (2)
Intrinsically disordered proteins in neurodegeneration. (2016) (2)
1H, 15N, and 13C resonance assignment of the C2A domain of rabphilin 3A. (2006) (2)
Letter to the Editor: Backbone resonance assignment of the homodimeric, 35 kDa chaperone CesT from enteropathogenic Escherichia coli (2005) (2)
Phase Separation in Biology and Disease; Current Perspectives and Open Questions. (2023) (2)
Structure of Citrate-bound Periplasmic Domain of Sensor Histidine Kinase CitA (2007) (1)
A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro (2022) (1)
Correction to: Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models (2019) (1)
Structural Impact of Tau P hosphorylation at Threonine 231 Graphical Abstract Highlights (2015) (1)
CONKUNITZIN-S2 - CONE SNAIL NEUROTOXIN - DENOVO STRUCTURE (2007) (1)
Structure of Tau(267-312) bound to Microtubules (2015) (1)
For Peer Review Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies (2017) (1)
Structure of serotonin receptors: molecular underpinning of receptor activation and modulation (2021) (1)
1 Supplementary Information for Dynamic Aha 1 Co-Chaperone Binding to Human Hsp 90 (2019) (1)
Erratum to: Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. (2021) (1)
Backbone resonance assignment of the homodimeric, 35 kDa chaperone CesT from enteropathogenic Escherichia coli. (2005) (1)
Contributions of the N-terminal intrinsically disordered region of the SARS-CoV-2 nucleocapsid protein to RNA-induced phase separation (2022) (1)
1H, 15N, and 13C Resonance Assignment of the C2A Domain of Rabphilin3A (2006) (1)
Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activit. (2022) (1)
Intrinsically Disordered Proteins: From Sequence and Conformational Toward Drug Discovery (2012) (1)
Special issue: Multicomponent lipid membranes—how molecular organisation leads to function (2021) (1)
Back Cover: Structural Integrity of the A147T Polymorph of Mammalian TSPO (ChemBioChem 10/2015) (2015) (0)
Contributions of the N‐terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA‐induced phase separation (2022) (0)
N-terminally acetylated beta-Synuclein (2017) (0)
SOLUTION STRUCTURE OF THE A147T VARIANT OF THE MITOCHONDRIAL TRANSLOCATOR PROTEIN (TSPO) IN COMPLEX WITH PK11195 (2015) (0)
Backbone and side-chain resonance assignment of the A147T polymorph of mouse TSPO in complex with a high-affinity radioligand (2015) (0)
NOE-based 3D structure of the monomeric partially-folded intermediate of CylR2 at 259K (-14 Celsius degrees) (2013) (0)
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage (2023) (0)
ROCK Inhibition by Fasudil as Disease-Modifying Translational Approach in the Treatment of Parkinson’s Disease and Amyotrophic Lateral Sclerosis (P2.346) (2016) (0)
Peptide Synthesis Solid-Phase Synthesis and Characterization of N-Terminally Elongated A b ¢ 3 – x-Peptides (2016) (0)
Small molecule approaches to dissecting the role of quaternary structure and tautomerase activity in regulating the biological functions of Macrophage Migration Inhibitory Factor (MIF) (2010) (0)
Site-Specific Effect of Amyloid B-Peptide (Aβ) Phosphorylation on Its Conformation and Aggregation (2011) (0)
A six-dimensional alpha proton detection-based APSY experiment for backbone assignment of intrinsically disordered proteins (2014) (0)
P3.001 SUMOylation regulates a-synuclein toxicity (2009) (0)
Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease (2021) (0)
Magnetic resonance spectroscopy of biomolecules (2018) (0)
Improved Physical Models Enable the Investigation of Molecular Recognition in Intrinsically Disordered Proteins at Atomistic Rsolution (2019) (0)
Introduction: Biophysics of biomolecular condensates (2021) (0)
RNA translocation mechanism of spliceosomal DEAH-box ATPases (2019) (0)
High Resolution Solid-state NMR structure of Kaliotoxin (2008) (0)
Chicago sky blue 6B inhibits α-synuclein aggregation and propagation (2022) (0)
identi fi cation of phase separation hot spots of Alzheimer ' s-related protein tau † (2019) (0)
Structure and Functions of Microtubule Associated Proteins Tau and MAP 2 c : Similarities and Differences SUPPLEMENTARY MATERIALS (2019) (0)
Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease (2016) (0)
Peptidyl Prolyl Isomerase A Modulates the Liquid–Liquid Phase Separation of Proline-Rich IDPs (2022) (0)
Intrinsically Disordered Proteins (2011) (0)
Regulation of Cytolysin Expression by Enterococcus faecalis: Role of CylR2 (2004) (0)
High resolution structure of MTSL-tagged CylR2. (2011) (0)
Conformational plasticity of the multi-domain Heterochromatin Protein 1 beta. (2013) (0)
Conformation and Dynamics of MAP 2 c Functionally specific binding regions of microtubule-associated protein 2 c exhibit distinct conformations and dynamics (2018) (0)
PPID CONTROLS TOXIC AMYLOID FORMATION THROUGH PROLINE ISOMERIZATION (2017) (0)
Tailor made activation segment for autoinhibition (2006) (0)
Doxycycline interferes with tau amyloid aggregation abolishing its associated neuronal toxicity (2020) (0)
Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view (2018) (0)
Structure of Tau(292-319) bound to F-actin (2017) (0)
High resolution Solid state NMR structure of Kaliotoxin bound to Potassium channel (2009) (0)
Structure of Tau(254-268) bound to F-actin (2018) (0)
Reply on RC2 (2021) (0)
Solution structure of the F87M/L110M variant of transthyretin in the monomeric state (2017) (0)
Interactive comment on “ Extending the applicability of P 3 D for structure determination of small molecules ” by Alain Ibáñez de Opakua (2020) (0)
High resolution structure and dynamics of CsPinA parvulin at physiological temperature (2013) (0)
NOE-based 3D structure of the monomer of CylR2 in equilibrium with predissociated homodimer at 266K (-7 Celsius degrees) (2013) (0)
Solution structure of the mitochondrial translocator protein (TSPO) in complex with its high-affinity ligand PK11195 (2014) (0)
Chicago sky blue 6B inhibits α-synuclein aggregation and propagation (2022) (0)
Solution structure of the T119M variant of transthyretin in its monomeric state (2017) (0)
SOLUTION STRUCTURE OF THE IMS DOMAIN OF THE MITOCHONDRIAL IMPORT PROTEIN TIM21 FROM S. CEREVISIAE (2014) (0)
NOE-based 3D structure of the CylR2 homodimer at 270K (-3 Celsius degrees) (2013) (0)
Biophysical Origins of Calcium-Inhibited Membrane Binding by the C2A Domain of Synaptotagmin-Like Protein 2 (2020) (0)
Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2 (2014) (0)
Routes of internalization for Melan-A/TAT fusion peptides differ considerably between human dendritic cells and other non-phagocytic cell types. (2014) (0)
Conformation and dynamics of intrinsically disordered microtubule associated protein 2c (MAP2c) (2018) (0)
Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors (2010) (0)
RNA polymerase II clustering through carboxy-terminal domain phase separation (2018) (0)
Capture of Dense Core Ves icles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4 Graphical Abstract Highlights (2017) (0)
Structure of Tau(254-290) bound to F-actin (2017) (0)
The C2A-C2B Linker Defines the High Affinity Ca 2 Binding (2007) (0)
Determining the Physico-Chemical Composition of Biomolecular Condensates from Spatially-Resolved NMR. (2023) (0)
Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau (2017) (0)
Molecular-level interplay between intrinsically disordered clients and Hsp90. (2023) (0)
Cover Picture: Dissociation of Amyloid Fibrils of α-Synuclein in Supercooled Water (Angew. Chem. Int. Ed. 27/2008) (2008) (0)
NOE-based 3D structure of the monomeric partially-folded intermediate of CylR2 at 257K (-16 Celsius degrees) (2013) (0)
Structure of the alpha-Synuclein PreNAC/Cyclophilin A-complex (2020) (0)
High-resolution structure determination of the CylR2 homodimer using intermonomer distances from paramagnetic relaxation enhancement and NMR dipolar couplings (2007) (0)
NOE-based 3D structure of the predissociated homodimer of CylR2 in equilibrium with monomer at 266K (-7 Celsius degrees) (2013) (0)
3D structure, ligand binding, autoinhibition, aggregation, and cellular distribution of wild type, mutant, and labeled alpha-synuclein (2005) (0)
1H, 15N and 13C resonance assigment of the transcription factor CylR2 from Enterococcus faecalis (2004) (0)
High resolution structure of the T55C mutant of CylR2. (2011) (0)
Supporting information for the article : Towards the functional oligomerisation state of tryptophane-rich sensory proteins (2014) (0)
NOE-based 3D structure of the CylR2 homodimer at 298K (2013) (0)
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation (2018) (0)
High resolution structure of native CylR2 (2011) (0)
Residual Dipolar Couplings 2004 EMBO Summer School Il Ciocco Italy (2004) (0)
Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress (2023) (0)
A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol (2020) (0)
From integrative atomic-resolution ensembles of disordered proteins to simulations of phase-separated condensates. (2023) (0)
Backbone 1H, 13C, 15N and 13C-beta Chemical Shift Assignments for alpha-synuclein at pH 3 (2009) (0)
Tenth International Symposium on the Hsp90 chaperone machine (2023) (0)
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex (2018) (0)
Reply on RC1 (2021) (0)
ILIV-3 Elucidation of conformation and configuration of natural compounds using residual dipolar couplings enhanced NMR(Spectroscopy in Natural Products Chemistry) (2006) (0)
P9 Structural Characterization of FGFR-ligand interaction by NMR spectroscopy (2015) (0)
Fast Motions Dominate Dynamics of Intrinsically Disordered Tau Protein at High Temperatures. (2022) (0)
Supporting Information The Molecular Basis of the Interaction of Cyclophilin A with a-Synuclein (2020) (0)
NOE-based 3D structure of the monomeric intermediate of CylR2 at 262K (-11 Celsius degrees) (2013) (0)
Dynamical component exchange in a model phase separating system: an NMR-based approach. (2021) (0)
Lipid Protein Interactions and Dynamical Properties of VDAC 1 channel (2011) (0)
Improved validation of IDP ensembles by one-bond Cα–Hα scalar couplings (2015) (0)
Structure of PPIA in complex with PR dipeptide repeat (2021) (0)
Structural and dynamical effects of amyloid beta phosphorylation at serine 26. (2013) (0)
Lysine/RNA-interactions drive and regulate biomolecular condensation (2019) (0)
Science Journals — AAAS (2020) (0)
Solution Structure of the Coiled-Coil Domain of cGMP-dependent Protein Kinase Ia (2005) (0)
H-1, N-15, and C-13 resonance assignment of the C2A domain of rabphilin3A (2006) (0)
E73V mutant of the human voltage-dependent anion channel (2016) (0)
Snu17p-Bud13p structure intermediate during RES complex assembly (2015) (0)
Mutant alpha-synuclein with increased toxicity. (2010) (0)
STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES (1999) (0)

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