Mart Saarma

Mart Saarma's AcademicInfluence.com Rankings

Mart Saarma

Biology

#9807

World Rank

#13055

Historical Rank

Neuroscience

#1461

World Rank

#1511

Historical Rank

biology Degrees

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Biology

Mart Saarma's Degrees

Masters Biochemistry University of Tartu

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Mart Saarma's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation (1999) (2052)
The GDNF family: Signalling, biological functions and therapeutic value (2002) (1711)
Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. (2000) (1349)
Defects in enteric innervation and kidney development in mice lacking GDNF (1996) (1184)
Multiple promoters direct tissue-specific expression of the rat BDNF gene (1993) (847)
GDNF signalling through the Ret receptor tyrosine kinase (1996) (821)
Functional receptor for GDNF encoded by the c-ret proto-oncogene (1996) (816)
Novel functions and signalling pathways for GDNF (2003) (632)
BDNF-induced TrkB activation down-regulates the K+–Cl− cotransporter KCC2 and impairs neuronal Cl− extrusion (2002) (525)
GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant? (1999) (495)
Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2 (2004) (488)
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo (2007) (428)
Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. (1997) (381)
Rescue of Hearing, Auditory Hair Cells, and Neurons by CEP-1347/KT7515, an Inhibitor of c-Jun N-Terminal Kinase Activation (2000) (309)
Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear (1993) (308)
Retarded Growth and Deficits in the Enteric and Parasympathetic Nervous System in Mice Lacking GFRα2, a Functional Neurturin Receptor (1999) (300)
KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development (2007) (298)
Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia. (1992) (295)
Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Neurorestorative in Rat Model of Parkinson's Disease (2009) (254)
Development and plasticity of meningeal lymphatic vessels (2017) (244)
Coordinated expression and function of neurotrophins and their receptors in the rat inner ear during target innervation (1994) (210)
Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise trauma (1998) (196)
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors (2019) (194)
Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin (2011) (193)
Novel CDNF/MANF family of neurotrophic factors (2010) (193)
GDNF triggers a novel Ret‐independent Src kinase family‐coupled signaling via a GPI‐linked GDNF receptor α1 (1999) (189)
GDNF family receptor complexes are emerging drug targets. (2007) (188)
Dependence of kidney morphogenesis on the expression of nerve growth factor receptor. (1991) (187)
MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain (2008) (179)
Other neurotrophic factors: Glial cell line‐derived neurotrophic factor (GDNF) (1999) (173)
Developmental up‐regulation of KCC2 in the absence of GABAergic and glutamatergic transmission (2003) (172)
A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. (2003) (163)
MANF is indispensable for the proliferation and survival of pancreatic β cells. (2014) (154)
Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons (2009) (143)
Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential (2017) (139)
Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons* (2010) (136)
Distribution of GABA receptor ρ subunit transcripts in the rat brain (1998) (133)
Mesencephalic astrocyte‐derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats (2009) (133)
GDNF – a stranger in the TGF-β superfamily? (2000) (131)
GDNF family ligands and receptors are differentially regulated after brain insults in the rat (1999) (129)
Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease (2011) (126)
The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. (2009) (124)
Neurotrophins as in vitro growth cone guidance molecules for embryonic sensory neurons (1997) (120)
Human Glial Cell Line-derived Neurotrophic Factor Receptor α4 Is the Receptor for Persephin and Is Predominantly Expressed in Normal and Malignant Thyroid Medullary Cells* (2001) (119)
Posttraumatic GABAA-Mediated [Ca2+]i Increase Is Essential for the Induction of Brain-Derived Neurotrophic Factor-Dependent Survival of Mature Central Neurons (2008) (118)
Expression and Alternative Splicing of Mouse Gfra4 Suggest Roles in Endocrine Cell Development (2000) (113)
CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery after MPTP Treatment in Mice (2012) (112)
GDNF promotes tubulogenesis of GFRα1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase (2003) (112)
Promotion of seminomatous tumors by targeted overexpression of glial cell line-derived neurotrophic factor in mouse testis. (2001) (112)
BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met (2015) (109)
Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases (2007) (108)
Current disease modifying approaches to treat Parkinson’s disease (2016) (99)
Glial Cell Line-Derived Neurotrophic Factor Rescues Target-Deprived Sympathetic Spinal Cord Neurons But Requires Transforming Growth Factor-β as Cofactor In Vivo (1999) (99)
Nerve growth factor and brain‐derived neurotrophic factor mRNAs are regulated in distinct cell populations of rat heart after ischaemia and reperfusion (2001) (92)
Cloning, mRNA Distribution and Chromosomal Localisation of the Gene for Glial Cell Line-Derived Neurotrophic Factor Receptor β, a Homologue to GDNFR-α (1997) (89)
Expression of neurotrophin receptors during rat tooth development is developmentally regulated, independent of innervation, and suggests functions in the regulation of morphogenesis and innervation (1996) (89)
GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function (2015) (88)
The nucleotide sequence of potato virus A genomic RNA and its sequence similarities with other potyviruses. (1994) (87)
Neuron-specific Bcl-2 Homology 3 Domain-only Splice Variant of Bak Is Anti-apoptotic in Neurons, but Pro-apoptotic in Non-neuronal Cells* (2001) (86)
The Structure of the Glial Cell Line-derived Neurotrophic Factor-Coreceptor Complex (2008) (85)
Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth (1993) (83)
Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems☆ (2003) (83)
Constitutive Ret Activity in Knock-In Multiple Endocrine Neoplasia Type B Mice Induces Profound Elevation of Brain Dopamine Concentration via Enhanced Synthesis and Increases the Number of TH-Positive Cells in the Substantia Nigra (2007) (78)
The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation (2004) (77)
GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway (2003) (76)
GDNF - a stranger in the TGF-beta superfamily? (2000) (75)
Neurturin is a neurotrophic factor for penile parasympathetic neurons in adult rat. (2000) (75)
Characterization of the Intracellular Localization, Processing, and Secretion of Two Glial Cell Line-Derived Neurotrophic Factor Splice Isoforms (2010) (73)
Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells (1999) (72)
Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy. (2015) (72)
Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons (2011) (71)
Seizures induce widespread upregulation of cystatin B, the gene mutated in progressive myoclonus epilepsy, in rat forebrain neurons (2000) (71)
Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesis (1997) (71)
Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis (1997) (71)
Stroke induces widespread changes of gene expression for glial cell line-derived neurotrophic factor family receptors in the adult rat brain (2001) (71)
Phytepsin, a barley vacuolar aspartic proteinase, is highly expressed during autolysis of developing tracheary elements and sieve cells. (1998) (70)
Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease (2015) (70)
Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease (2013) (69)
The messenger RNAs for both glial cell line-derived neurotrophic factor receptors, c- ret and GDNFRα, are induced in the rat brain in response to kainate-induced excitation (1998) (69)
Expression of neurotrophins and Trk receptors in the developing, adult, and regenerating avian cochlea. (1997) (69)
Large-scale production of dsRNA and siRNA pools for RNA interference utilizing bacteriophage ϕ6 RNA-dependent RNA polymerase (2007) (67)
Developmental expression of palmitoyl protein thioesterase in normal mice. (1999) (65)
In heterozygous GDNF knockout mice the response of striatal dopaminergic system to acute morphine is altered (2006) (64)
A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation (2003) (62)
Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson’s Disease (2016) (60)
GDNF recruits the signaling crew into lipid rafts (2001) (60)
Mitogen-Activated Protein Kinase (MAPK) Pathway Regulates Branching by Remodeling Epithelial Cell Adhesion (2014) (60)
Expression of mRNAs for neurotrophins and their receptors in developing rat heart. (1996) (60)
Increased extracellular dopamine concentrations and FosB/ΔFosB expression in striatal brain areas of heterozygous GDNF knockout mice (2004) (59)
GDNF family receptors in the embryonic and postnatal rat heart and reduced cholinergic innervation in mice hearts lacking Ret or GFRα2 (2000) (59)
MANF protects human pancreatic beta cells against stress-induced cell death (2018) (58)
GDNF family ligands activate multiple events during axonal growth in mature sensory neurons (2004) (57)
Hydrolytic specificity of the barley grain aspartic proteinase. (1993) (56)
Neuronal characteristics in embryonic renal stroma. (1994) (56)
Thyroxin regulates BDNF expression to promote survival of injured neurons (2009) (56)
SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET. (2013) (56)
GDNF and its receptors in the regulation of the ureteric branching. (1999) (54)
Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2. (2000) (53)
GDNF is not required for catecholaminergic neuron survival in vivo (2015) (52)
Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes (2016) (52)
Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons (2009) (51)
Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice. (2006) (51)
Neurotrophic Factors in the Auditory Periphery (1999) (50)
Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra (2014) (50)
Death Receptors and Caspases But Not Mitochondria Are Activated in the GDNF- or BDNF-Deprived Dopaminergic Neurons (2008) (49)
Regulatory elements and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter. (1992) (48)
Signalling mechanisms underlying development and maintenance of dopamine neurons (2008) (47)
Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice (2015) (47)
Distinct roles for GFRα1 and GFRα2 signalling in different cranial parasympathetic ganglia in vivo (2000) (47)
GABA receptor ρ subunit expression in the developing rat brain (2005) (47)
Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity (2015) (45)
Neurotrophin 3 rescues neuronal precursors from apoptosis and promotes neuronal differentiation in the embryonic metanephric kidney. (1995) (45)
GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop (2020) (45)
Persephin signaling through GFRα1: The potential for the treatment of Parkinson's disease (2010) (43)
Characterization of Symmetric Complexes of Nerve Growth Factor and the Ectodomain of the Pan-neurotrophin Receptor, p75NTR* (2005) (43)
MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex (2017) (43)
GDNF is required for kidney development and enteric innervation. (1996) (43)
Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model (2013) (42)
CDNF Protein Therapy in Parkinson’s Disease (2019) (42)
A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat (2017) (42)
Glial cell line-derived neurotrophic factor is expressed in penis of adult rat and retrogradely transported in penile parasympathetic and sensory nerves (2000) (41)
A deep convolutional neural network approach for astrocyte detection (2017) (41)
Molecular Dynamics Simulations of the Interactions between Glial Cell Line-Derived Neurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands (2018) (39)
Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action (2017) (38)
RET(MEN 2B) is active in the endoplasmic reticulum before reaching the cell surface (2007) (36)
Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease (2016) (36)
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function (2019) (36)
Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster (2016) (36)
Neurturin mRNA expression suggests roles in trigeminal innervation of the first branchial arch and in tooth formation (1998) (35)
The rho 1 GABA receptor cloned from rat retina is down-modulated by protons. (1996) (35)
Neuroplastin Modulates Anti-inflammatory Effects of MANF (2020) (35)
A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus (2008) (34)
Interaction of 5-S RNA, 5.8-S RNA and tRNA with rat-liver ribosomal proteins. (1978) (34)
Neurotrophin-3 is a target-derived neurotrophic factor for penile erection-inducing neurons (2005) (33)
Nerve growth factor-induced rapid reorganization of microfilaments in PC12 cells: possible roles of different second messenger systems. (1990) (32)
Effects of repeated morphine on locomotion, place preference and dopamine in heterozygous glial cell line‐derived neurotrophic factor knockout mice (2007) (32)
Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo (2011) (32)
Molecularly imprinted polymer-based SAW sensor for label-free detection of cerebral dopamine neurotrophic factor protein (2020) (32)
mRNAS for one, two or three members of trk receptor family are expressed in single rat trigeminal ganglion neurons. (1996) (31)
Implementation of deep neural networks to count dopamine neurons in substantia nigra (2018) (31)
Structure of the human genomic region homologous to the bovine prochymosin-encoding gene. (1990) (30)
c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson’s Disease (2016) (30)
Neurotrophins and ciliary neurotrophic factor: their biology and pathology. (1994) (29)
Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals (2011) (29)
Short-term Preoperative Dietary Restriction Is Neuroprotective in a Rat Focal Stroke Model (2014) (29)
Glial cell line-derived neurotrophic factor: Characterization of mammalian posttranslational modifications (2013) (29)
Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss (2020) (28)
Functional Characterization of Two Splice Variants of Rat Bad and Their Interaction with Bcl-w in Sympathetic Neurons (2001) (27)
Dampened Amphetamine-Stimulated Behavior and Altered Dopamine Transporter Function in the Absence of Brain GDNF (2017) (27)
Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha. (1997) (27)
Two distinct conformations of rat liver ribosomal 5S RNA. (1982) (27)
Characterization of the rat light neurofilament (NF‐L) gene promoter and identification of NGF and cAMP responsive regions (1995) (26)
The neuronal ceroid lipofuscinosis Cln8 gene expression is developmentally regulated in mouse brain and up-regulated in the hippocampal kindling model of epilepsy (2005) (26)
Characterization of the striatal dopaminergic neurotransmission in MEN2B mice with elevated cerebral tissue dopamine (2008) (25)
Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra (2017) (24)
Neurotrophic factors for disease-modifying treatments of Parkinson's disease: gaps between basic science and clinical studies (2020) (24)
Can Growth Factors Cure Parkinson's Disease? (2020) (23)
The first cysteine-rich domain of the receptor GFRalpha1 stabilizes the binding of GDNF. (2005) (23)
Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice (2019) (23)
Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features (2020) (21)
Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson’s Disease (2018) (21)
MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System (2020) (21)
Nucleotide sequence of the 3'-terminal region of potato virus A RNA. (1992) (21)
Large-scale production of dsRNA and siRNA pools for RNA interference utilizing bacteriophage phi6 RNA-dependent RNA polymerase. (2007) (21)
Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease (2018) (21)
Glial cell line-derived neurotrophic factor family ligands and their therapeutic potential (2016) (21)
Glial Cell Line–Derived Neurotrophic Factor Receptor Rearranged During Transfection Agonist Supports Dopamine Neurons In Vitro and Enhances Dopamine Release In Vivo (2019) (20)
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor (2021) (20)
GABA receptor rho subunit expression in the developing rat brain. (2005) (20)
Increased Serum Levels of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Subjects With Parkinson’s Disease (2019) (20)
1H, 13C and 15N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor (2010) (19)
Nomenclature of GPI-Linked Receptors for the GDNF Ligand Family (1997) (19)
Characterization of Drosophila GDNF Receptor-Like and Evidence for Its Evolutionarily Conserved Interaction with Neural Cell Adhesion Molecule (NCAM)/FasII (2012) (19)
Nomenclature of GPI-Linked Receptors for the GDNF Ligand Family (1997) (19)
Development of adrenal chromaffin cells is largely normal in mice lacking the receptor tyrosine kinase c-Ret (2003) (18)
Levels of glial cell line‐derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson’s disease (2019) (18)
PSPN/GFRα4 has a significantly weaker capacity than GDNF/GFRα1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth (2004) (18)
Neurotrophic Factors in Parkinson’s Disease: Clinical Trials, Open Challenges and Nanoparticle-Mediated Delivery to the Brain (2021) (18)
Location of single-stranded and double-stranded regions in rat liver ribosomal 5S RNA and 5.8S RNA. (1981) (18)
The mouse soluble GFRα4 receptor activates RET independently of its ligand persephin (2007) (18)
Neurotrophic factors switch between two signaling pathways that trigger axonal growth (2007) (17)
Transcriptional regulation of neurofilament expression by protein kinase A (1997) (16)
Tissue-specific expression of rat light neurofilament promoter-driven reporter gene in transgenic mice. (1993) (16)
Gfra1 Underexpression Causes Hirschsprung’s Disease and Associated Enterocolitis in Mice (2018) (16)
The interaction of transfer ribonucleic acid with 50 S ribosomal subunit proteins (1977) (16)
Cloning and sequencing of the 3'-terminal region of potato virus YN (Russian isolate) RNA genome. (1990) (16)
Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro (2017) (15)
Localization of Nerve Cells in the Developing Rat Tooth (1997) (15)
Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo (2021) (14)
Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons (2021) (13)
Monoclonal antibody immunoaffinity chromatography of the nerve growth factor from snake venoms. (1987) (13)
Small-Molecule Ligands as Potential GDNF Family Receptor Agonists (2018) (13)
Induced expression of neurotrophins in transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine (1996) (13)
Mutational analysis of N-Bak reveals different structural requirements for antiapoptotic activity in neurons and proapoptotic activity in nonneuronal cells (2003) (13)
Monoclonal antibodies against Vipera lebetina venom nerve growth factor cross-react with other snake venom nerve growth factors. (1987) (12)
Antisense inhibition of low-affinity nerve growth factor receptor in kidney cultures: Power and pitfalls (1994) (12)
Body weight regulation via MT1-MMP-mediated cleavage of GFRAL (2022) (12)
Toward understanding the neuronal pathogenesis of aspartylglucosaminuria: expression of aspartylglucosaminidase in brain during development. (1999) (11)
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats (2018) (11)
Isolation and characterization of nerve growth factor from Vipera berus (common viper) venom (1986) (11)
Novel agonist of GDNF family ligand receptor RET for the treatment of experimental neuropathy (2016) (11)
Obesity: Receptors identified for a weight regulator (2017) (11)
Isolation of rat liver 5S RNA genes. (1980) (10)
Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism (2021) (10)
In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway (2017) (10)
RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications (2015) (10)
Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy (2019) (10)
Assignment of human prochymosin pseudogene to chromosome 1. (1991) (10)
Cerebral dopamine neurotrophic factor is essential for enteric neuronal development, maintenance, and regulation of gastrointestinal transit (2019) (9)
PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential (2020) (9)
Cellular / Molecular Mechanism of Activity-Dependent Downregulation of the Neuron-Specific KCl Cotransporter KCC 2 (2004) (9)
PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth. (2004) (9)
Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors (2020) (9)
MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α (2020) (7)
Pyrimidine-rich oligonucleotides from rat-liver ribosome surface. (1975) (7)
GDNF receptor agonist supports dopamine neurons in vitro and protects their function in animal model of Parkinson’s (2019) (7)
Immobilized eukaryotic 5.8 S RNA binds escherichia coli and rat liver ribosomal proteins (1979) (7)
The domain for transfer ribonucleic acid binding to the Escherichia coli ribosome (1978) (7)
CDNF and MANF regulate ER stress in a tissue-specific manner (2022) (6)
Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats (2021) (6)
Sensory neurons from N-syndecan-deficient mice are defective in survival (2008) (6)
New aspects of the eukaryotic ribosomal subunit interaction (1979) (6)
Effects of Brain-Derived Neurotrophic Factor and Neurotrophin-4 on Embryonic Rat Sensory Neurons (1995) (6)
Small-Molecule Ligands that Bind the RET Receptor Activate Neuroprotective Signals Independent of but Modulated by Coreceptor GFRα1 (2020) (6)
CDNF rescues motor neurons in three animal models of ALS by targeting ER stress (2020) (5)
Small Molecules and Peptides Targeting Glial Cell Line-Derived Neurotrophic Factor Receptors for the Treatment of Neurodegeneration (2020) (5)
Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon. (2021) (5)
Sensitive time-resolved fluoroimmunoassay of nerve growth factor and the disappearance of nerve growth factor from rat pheochromocytoma PC12 cell culture medium. (1989) (4)
Novel computational models for predicting dopamine interactions (2008) (4)
Sequencing of the rat light neurofilament promoter reveals differences in methylation between expressing and non-expressing cell lines, but not tissues. (1995) (4)
GFL Neurotrophic Factors: Physiology and Pharmacology (2009) (4)
Endoplasmic Reticulum Stress Regulators: New Drug Targets for Parkinson’s Disease (2021) (4)
14th European Congress on Digital Pathology (2019) (3)
Small Molecular Weight ARTN Mimetic for the Treatment of Neuropathic Pain (2012) (3)
Parkinson’s disease: towards better preclinical models and personalized treatments (2016) (3)
GDNF FAMILY SIGNALLING IN EXOCRINE TISSUES: DISTINCT ROLES FOR GFRα1 AND GFRα2 IN DIFFERENT CRANIAL PARASYMPATHETIC GANGLIA. (2000) (3)
Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT (2012) (3)
GDNF receptors as a drug target for neural repair (2007) (3)
[Nerve growth factor induces rapid redistribution of f-actin in pheochromocytoma PC12 cells]. (1988) (3)
Correction: GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function (2016) (3)
GDNF mimetics delivery by porous silicon nanoparticles for improved Parkinson’s disease management (2018) (2)
Expression of GFRα-1, GFRα-2, and c-Ret mRNAs in rat adrenal gland (2000) (2)
[Neurotrophic growth factors in the development and plasticity of nervous system]. (1999) (2)
Structure and chromosomal localization of the human prochymosin pseudogene. (1991) (2)
MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea (2021) (2)
GDNF Receptor Agonist Alleviates Motor Imbalance in Unilateral 6-Hydroxydopamine Model of Parkinson’s Disease (2020) (2)
CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival (2022) (2)
Adeno-Associated Viral (AAV) Vector Expressing Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Protects Cortical Neurons Against Ischemia-Induced Toxicity in Rats (2009) (2)
5 S RNA and 5.8 S RNA build up eukaryotic subribosomal domains active in tRNA binding (1981) (2)
[Monoclonal antibodies to the nerve tissue growth factor from Vipera lebetina venom]. (1984) (2)
New Mouse Models for Studying Postnatal Role of GDNF In Vivo (2010) (1)
The role of SorLA in neurotrophic activity and complex behavior (2013) (1)
3.220 NIGROSTRIATAL DOPAMINERGIC SYSTEM OF CONDITIONAL GDNF KNOCK-OUT MICE DOES NOT DISPLAY INCREASED VULNERABILITY TO AGING (2012) (1)
Role of CDNF in SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis (2018) (1)
Small-molecule inhibitors of the RNA m6A demethylase FTO potently support the survival of dopamine neurons (2021) (1)
Retinal neuroprotection using small molecule GDNF mimetics (2014) (1)
[Degradation of messenger RNA, ribosomal RNA and 2-5A-dependent inhibition of protein biosynthesis]. (1988) (1)
Exclusion of the p75 neurotrophin receptor gene as a candidate gene for Meckel syndrome. (1997) (1)
Parkinson’s disease: towards better preclinical models and personalized treatments (2016) (1)
The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte–Derived Neurotrophic Factor Promote Post-ischemic Neurological Recovery, Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity (2022) (1)
CDNF is a novel neurotrophic factor for dopaminergic neurons in vivo (2008) (1)
3.217 CDNF PROTECTS THE NIGROSTRIATAL DOPAMINE SYSTEM AND PROMOTES RECOVERY AFTER MPTP TREATMENT IN MICE (2012) (1)
Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra (2014) (1)
The GDNF Family: From Neurotrophic Factors to Oncogenesis (2001) (1)
Antidepressants act by binding to the transmembrane domain of TRKB receptor (2019) (1)
Pyrimidine rich surface of ribosomes. (1974) (1)
[Nucleotide sequence and transcription of the highly repetitive EcoRI-sequences in the rat DNA]. (1986) (0)
Neurotrophic factor MANF and its uses (2008) (0)
A deep convolutional neural network approach for astrocyte detection (2018) (0)
[Conformational isomers of rat liver 5S ribosomal RNA]. (1978) (0)
Methods for prophylaxis and treatment of damage to the perception hairs cells and cochlear neurons (1999) (0)
Panel 12: Department of Organismal Biology, Ecology and Genetics, Department of Department of Cell and Molecular Biology (2017) (0)
Restoring dopaminergic nerve cells in Parkinson’s disease (2017) (0)
P2.002 Intranigral injection of CDNF promotes functional recovery of nigrostriatal dopaminergic circuit in a lesion model of Parkinson's disease (2009) (0)
[Secondary structure of the 5'-terminal region of the 18S ribosomal RNA5.3S fragment from the rat liver]. (1987) (0)
Glial cell line-derived neurotrophic factor family ligands and their therapeutic potential (2016) (0)
Neurotrophic factors in the treatment of neurodegenerative diseases (2007) (0)
Isolation and characterization of nerve growth factor from Vipera berus berus (common viper) venom. (1986) (0)
21-P035 Drosophila neurotrophic factor DmMANF (2009) (0)
[Binding of Escherichia coli 50S ribosomal subunit proteins with two large 5S RNA fragments]. (1981) (0)
GLORIA: understanding chronic pain and new druggable targets (2014) (0)
B30 MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN HETEROZYGOUS GDNF KNOCKOUT MICE (2005) (0)
Organization and Function of the Eucaryotic Genome (1987) (0)
S.4.05 Novel neurotrophic factors for the treatment of neurodegenerative diseases (2009) (0)
GDNF, CDNF and MANF have divergent effects on nigrostriatal dopamine neurochemistry in rats (2018) (0)
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats (2018) (0)
50 Neurotrophic factors as neuronal growth cone guidance molecules (1996) (0)
Cover Image, Volume 528, Issue 14 (2020) (0)
Neurotrophic factors in the treatment of peripheral nervous system dysfunction pelvic (1999) (0)
Uses of a neurotrophic factor (2005) (0)
Effects of acute morphine on metabolism of dopamine in dorsal striatum of heterozygous GDNF knockout mice (2003) (0)
[Isolation of 5S RNA-protein complexes from rat liver ribosomes]. (1983) (0)
FUNCTIONAL ACTIVITIES OF 5S RNA- AND 5.8S RNA-PROTEIN COMPLEXES IN EUKARYOTIC TRANSLATION (1981) (0)
Induction and Regulation of the Expression of NGF-Induced Genes in PC 12 Cells (1987) (0)
C-terminal domain of mesencephalic astrocyte-derived neurotrophic factor (MANF) (2010) (0)
Current disease modifying approaches to treat Parkinson’s disease (2015) (0)
A56 CONSTITUTIVE RET RECEPTOR TYROSINE KINASE ACTIVITY LEADS TO INCREASED CEREBRAL CONCENTRATION OF DOPAMINE AND TO ENHANCEMENT OF COCAINE-INDUCED LOCOMOTOR ACTIVITY IN TRANSGENIC MEN2B MICE (2005) (0)
110 Roles of gdnf in the development of nervous system and kidney (1996) (0)
Characterization of the SOD1-G93A mouse model of Amyotrophic lateral sclerosis and a promising treatment for the disease (2018) (0)
Editorial Board (2007) (0)
BMC Neuroscience BioMed Central (2003) (0)
Editorial for the special issue neurotrophic factors (2020) (0)
MANF neurotrophic factor and uses thereof (2009) (0)
Human mesencephalic astrocyte-derived neurotrophic factor (MANF) (2009) (0)
To celebrate the 80th birthday of Klaus Unsicker: discovery of a new growth factor and studies on the effects of growth factors on adrenal chromaffin cells and neurons (2022) (0)
Use of nucleotide sequences of protein synthesis, and to increase the expression of proteins (2000) (0)
Characterization of the structural and functional determinants of MANF/CDNF proteins using Drosophila model (2012) (0)
miRNA antagonists for use in treating neurodegenerative disorders by increasing expression of GDNF (2012) (0)
Crystallization and preliminary X-ray analysis of nerve growth factor from Vipera lebetina (1991) (0)
MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α. (2023) (0)
[Binding of tetranucleotides with 5S RNA from liver]. (1974) (0)
Compositions on the basis of GFR-alpha-4 and their applications (2000) (0)
a neurotrophic factor protein uses. (2005) (0)
Neurons Unique Mechanism to Rescue Apoptotic Neurotrophic Factor ( MANF ) Has a Mesencephalic Astrocyte-derived Protein Structure and Folding : (2011) (0)
Drosophila gene encoding a homolog of the novel human neurotrophic factor MANF (2006) (0)
Neuroprotective effects of coadministration of HB-GAM and GDNF in a rat model of Parkinson's disease (2008) (0)
N-terminal domain of human conserved dopamine neurotrophic factor (CDNF) (2009) (0)
Studies on the glial cell-line derived neurotrophic factor (GDNF) co-receptor α1 (2002) (0)
[Affinity labeling of (2',5')-oligoadenylate-activated endonuclease [32P]-2',5'A and its analogs]. (1985) (0)
Rescue and gene silencing experiments to dissect the DmMANF mutant lethality (2009) (0)
CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress. (2023) (0)
P2.016 Neuroprotective effects of VEGF-C in the 6-OHDA rat model of Parkinson's disease (2009) (0)
Hippocampal Pyramidal Cells Mediated Depolarizing Responses in - Receptor A Inhibitory Nature of Tiagabine-Augmented GABA (2015) (0)
S.11.05 Growth factors in the treatment of neurodegenerative diseases (2006) (0)
Studies on interaction of 5 S RNA with ribosomal proteins (1987) (0)
GFR? -4 of the genus or substances derived therefrom and their use for (2000) (0)
GDNF products in the preparation of a perhesukuisten compounds for the treatment of testicular cancer for the (2000) (0)
The crystal structure of GDNF family co-receptor alpha 1 domain 3 (2004) (0)
Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage (2023) (0)
Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss (2020) (0)
Transgenic mice overexpressing truncated trkB receptor in neurons (1998) (0)
GDNF splice variants and their uses (2007) (0)

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What Schools Are Affiliated With Mart Saarma?

Mart Saarma is affiliated with the following schools:

University of Helsinki