Martin Jínek
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Martin Jínekbiology Degrees
Biology
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#17187
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Cell Biology
#759
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#775
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Molecular Biology
#2325
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#2360
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Biology
Martin Jínek's Degrees
- PhD Molecular and Cell Biology University of California, Berkeley
- Bachelors Biochemistry Charles University
Why Is Martin Jínek Influential?
(Suggest an Edit or Addition)Martin Jínek's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity (2012) (11694)
- RNA-programmed genome editing in human cells (2013) (1897)
- DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 (2014) (1472)
- Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease (2014) (969)
- Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation (2014) (955)
- A three-dimensional view of the molecular machinery of RNA interference (2009) (724)
- Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease (2010) (614)
- A prudent path forward for genomic engineering and germline gene modification (2015) (565)
- Structural biology of nucleocytoplasmic transport. (2007) (515)
- Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. (2009) (431)
- Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a. (2017) (311)
- Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers (2017) (295)
- The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin α (2004) (272)
- Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense. (2009) (245)
- Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes (2016) (220)
- Structural insights into the molecular mechanism of the m6A writer complex (2016) (217)
- Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a. (2019) (188)
- An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3 (2011) (183)
- Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay. (2011) (152)
- Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. (2016) (152)
- Structural insights into the molecular mechanism of the m(6)A writer complex (2016) (148)
- Cas9 versus Cas12a/Cpf1: Structure–function comparisons and implications for genome editing (2018) (138)
- CrispRVariants charts the mutation spectrum of genome engineering experiments (2016) (123)
- CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations (2017) (118)
- Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6 (2016) (113)
- In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels (2021) (112)
- Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation (2010) (109)
- Structures of the tRNA export factor in the nuclear and cytosolic states (2009) (107)
- Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair (2018) (104)
- Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations (2016) (87)
- In vitro enzymology of Cas9. (2014) (84)
- Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases (2013) (82)
- An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish (2015) (80)
- Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9 (2017) (77)
- DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute (2019) (70)
- Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex (2018) (69)
- Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics (2019) (66)
- Mechanistic insights into mRNA 3′-end processing (2019) (60)
- Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain (2018) (56)
- Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex (2017) (55)
- Molecular architectures and mechanisms of Class 2 CRISPR-associated nucleases. (2017) (52)
- Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6 (2020) (51)
- Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes (2017) (47)
- Molecular basis for cytoplasmic RNA surveillance by uridylation‐triggered decay in Drosophila (2016) (46)
- Catalytic Mechanism of Non-Target DNA Cleavage in CRISPR-Cas9 Revealed by Ab Initio Molecular Dynamics. (2020) (43)
- Data-collection strategy for challenging native SAD phasing (2016) (43)
- Structural insights into the Notch-modifying glycosyltransferase Fringe (2006) (41)
- Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes (2018) (40)
- Hakai is required for stabilization of core components of the m6A mRNA methylation machinery (2021) (39)
- The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. (2008) (32)
- Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5 (2013) (30)
- Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. (2010) (30)
- Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis (2019) (25)
- In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target. (2015) (24)
- Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a (2020) (23)
- Target site selection and remodelling by type V CRISPR-transposon systems (2021) (22)
- Introducing gene deletions by mouse zygote electroporation of Cas12a/Cpf1 (2019) (18)
- Structural basis for Cas9 off-target activity (2021) (17)
- Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells. (2021) (17)
- Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs (2018) (16)
- R-loop formation and conformational activation mechanisms of Cas9 (2022) (16)
- ANGEL2 is a member of the CCR4 family of deadenylases with 2′,3′-cyclic phosphatase activity (2020) (15)
- Use of RNA tertiary interaction modules for the crystallisation of the spliceosomal snRNP core domain. (2010) (13)
- Preparation and electroporation of Cas12a/Cpf1-guide RNA complexes for introducing large gene deletions in mouse embryonic stem cells. (2019) (13)
- Heterologous Expression and Purification of CRISPR-Cas12a/Cpf1. (2018) (12)
- Structural basis for acceptor RNA substrate selectivity of the 3′ terminal uridylyl transferase Tailor (2018) (12)
- In vitro Generation of CRISPR-Cas9 Complexes with Covalently Bound Repair Templates for Genome Editing in Mammalian Cells. (2019) (11)
- Crystal structure of the C‐terminal 2′,5′‐phosphodiesterase domain of group a rotavirus protein VP3 (2015) (9)
- Structural basis for the assembly of the type V CRISPR-associated transposon complex (2022) (9)
- Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain. (2018) (9)
- The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response. (2021) (9)
- Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR–Cas9 (2022) (8)
- Molecular architecture of the human tRNA ligase complex (2021) (7)
- Molecular mechanism of off-target effects in CRISPR-Cas9 (2018) (7)
- Author response: RNA-programmed genome editing in human cells (2013) (7)
- CRISPR-Directed Therapeutic Correction at the NCF1 Locus Is Challenged by Frequent Incidence of Chromosomal Deletions (2020) (6)
- Structural basis for guide RNA processing and seed-dependent DNA targeting and cleavage by CRISPR-Cas12a (2017) (5)
- Mechanistic Insights into the Cis- and Trans-acting Deoxyribonuclease Activities of Cas12a (2018) (5)
- Covalent linkage of the DNA repair template to the CRISPR/Cas9 complex enhances homology-directed repair (2017) (5)
- Specialized Weaponry: How a Type III-A CRISPR-Cas System Excels at Combating Phages. (2017) (5)
- Mechanism of R-loop formation and conformational activation of Cas9 (2021) (4)
- Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor (2021) (3)
- Methods and compositions for RNA-directed target DNA modification and for RNA-directed transcription modulation (2013) (3)
- CrispRVariants: precisely charting the mutation spectrum in genome engineering experiments (2016) (3)
- Two-Metal Ion Mechanism of DNA Cleavage in CRISPR-Cas9 (2019) (3)
- Type III CRISPR-Cas systems generate cyclic oligoadenylate second messengers to activate Csm6 RNases (2017) (3)
- Structural basis for RNA-mediated assembly of type V CRISPR-associated transposons (2022) (2)
- Author response: An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish (2015) (2)
- Author response: Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair (2018) (2)
- The CRISPR-RNA World: An Interview with Martin Jínek. (2020) (2)
- An Alpha-helical Lid Guides the Target DNA toward Catalysis in CRISPR-Cas12a (2022) (1)
- R-loop formation and conformational activation mechanisms of Cas9 (2022) (1)
- Molecular mechanism of target site selection and remodeling by type V CRISPR-associated transposons (2021) (1)
- Author Correction: Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex (2018) (1)
- The Oxidoreductase PYROXD1 Utilizes NAD(P)+ As an Antioxidant to Sustain tRNA Ligase Activity in Pre-tRNA Splicing and Unfolded Protein Response (2020) (1)
- Cover Image, Volume 9, Issue 5 (2018) (1)
- TPR repeat domain of O-linked GlcNAc transferase: similarities to importin alpha (2005) (1)
- Crystal structure of the Csy4-crRNA complex, monoclinic form (2010) (0)
- Crystal structure of S. pyogenes Cas9 (2014) (0)
- PAM-Flexible Genome Editing with an Engineered Chimeric Cas9 (2023) (0)
- Structure A of CRISPR endoribonuclease Cse3 bound to 19 nt RNA (2011) (0)
- Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate (2020) (0)
- Author response: Structural insights into the molecular mechanism of the m6A writer complex (2016) (0)
- Author Correction: Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex (2018) (0)
- Crystal structure of the KIX domain of human RECQL5 (domain-swapped dimer) (2013) (0)
- Crystal structure of FnCas12a bound to a crRNA (2017) (0)
- Structure and dynamics of off-target effects in CRISPR-Cas9. (2023) (0)
- Cas6 (TTHB231) product complex (2013) (0)
- Crystal structure of catalytically inactive FnCas12a in complex with a crRNA guide and a dsDNA target (2019) (0)
- Crystal structure of the LSM domain of LSM14 in complex with a C-terminal peptide of 4E-T (2018) (0)
- Cas6 (TTHA0078) substrate mimic complex (2013) (0)
- Editorial overview: Protein-nucleic acid interactions - cryo-EM, what else? (2019) (0)
- Transport out of the nucleus and beyond: molecular mechanisms (2005) (0)
- Crystal structure of DmTailor in complex with UMPNPP (2018) (0)
- Structure of the catalytic domain of mouse Manic Fringe (2006) (0)
- Guided DNA Endonuclease in Adaptive - A Programmable Dual-RNA (2013) (0)
- Crystal structure of the Csy4-crRNA complex, hexagonal form (2010) (0)
- Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in an open conformation (2010) (0)
- CRYSTAL STRUCTURE OF THE HUMAN CPSF160-WDR33 COMPLEX (2018) (0)
- Target-bound SpCas9 complex with TRAC full RNA guide (2021) (0)
- Enterococcus italicus Csm6 bound to cyclic hexa-2'-fluoro-hexa-dAMP (2020) (0)
- S0033583518000070jrv 1..11 (2018) (0)
- Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6 (2020) (0)
- Mechanistic basis for oxidative stress protection of the human tRNA ligase complex by the oxidoreductase PYROXD1 (2023) (0)
- Critical Role of Conserved Histidine Residues in Genome Editing and Recombination (2021) (0)
- Crystal structure of Thermus thermophilus Csm6 (2016) (0)
- Structure of the catalytic domain of mouse Manic Fringe in complex with UDP and manganese (2006) (0)
- Crystal structure of SpyCas9 variant VQR bound to sgRNA and TGAG PAM target DNA (2016) (0)
- Crystal structure of Mn-bound S.pyogenes Cas9 (2014) (0)
- Target-bound SpCas9 complex with AAVS1 all-RNA guide (2021) (0)
- A PAM-Induced Signalling Activates the Communication between HNH and RUVC in CRISPR-Cas9 (2018) (0)
- Crystal structure of catalytically inactive FnCas12 mutant bound to an R-loop structure containing a pre-crRNA mimic and full-length DNA target (2017) (0)
- Crystal structure of the conserved C-terminal region of Ge-1 (2008) (0)
- Crystal structure of Cas9-sgRNA-DNA complex solved by native SAD phasing (2016) (0)
- Crystal structure of the NYN domain of human MARF1 (2018) (0)
- The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha. (2004) (0)
- Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex (2018) (0)
- Cooperative Dynamics of REC-Nuc Lobes Prime Cas12a for DNA Processing (2021) (0)
- Crystal structure of Xrn1-substrate complex (2011) (0)
- Visualizing Structures of CRISPR-Cas9 DNA Editing Enzyme (2016) (0)
- Crystal structure of the PABC-TNRC6C complex (2010) (0)
- Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA (2010) (0)
- Single-Molecule Observation of Viral DNA Targeting by CRISPR/Cas Immune Systems (2013) (0)
- CRISPR-Cas9: Computational Insights Toward Improved Genome Editing (2017) (0)
- Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK (2010) (0)
- Multiplexed single-molecule experiments reveal Cas9 nucleosome invasion dynamics (2022) (0)
- Crystal structure of Cas9 bound to PAM-containing DNA target containing mismatches at positions 1-3 (2014) (0)
- Crystal structure of the human METTL3-METTL14 complex bound to SAH (2016) (0)
- Crystal structure of the Csy4-crRNA complex, orthorhombic form (2010) (0)
- Faculty Opinions recommendation of GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. (2013) (0)
- Crystal structure of Cas9 bound to PAM-containing DNA target with mismatches at positions 1-2 (2014) (0)
- Crystal structure of SpCas9 variant VRER bound to sgRNA and TGCG PAM target DNA (2016) (0)
- DNA-Induced Allosteric Control Regulates Activation of Cas12A (2021) (0)
- Correction to Supporting Information for Palermo et al., CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations (2017) (0)
- Structural insights into the molecular mechanism of the mA writer complex (2016) (0)
- Crystal structure of murine DHX37 in complex with RNA (2019) (0)
- Crystal structure of DmTailor in complex with CACAGU RNA (2018) (0)
- Eukaryotic expression, purification, crystallization and preliminary X-ray analysis of murine Manic Fringe. (2006) (0)
- Crystal structure of DmTailor in complex with GpU (2018) (0)
- Structure of Clostridium butyricum Argonaute bound to a guide DNA (5' deoxycytidine) and a 19-mer target DNA (2019) (0)
- Karyopherin cytosolic state (2009) (0)
- Multi-microsecond molecular dynamics unveils the mechanism of DNA traversal within CRISPR-Cas12a (2022) (0)
- Crystal structure of Cas9 bound to PAM-containing DNA target (2014) (0)
- Faculty Opinions recommendation of Transcriptome surveillance by selective termination of noncoding RNA synthesis. (2013) (0)
- Cas6 (TTHA0078) product complex (2013) (0)
- Target-bound SpCas9 complex with AAVS1 chimeric RNA-DNA guide (2021) (0)
- Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis (2022) (0)
- Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate (2010) (0)
- Principles of DNA cleavage in CRISPR-Cas9. (2023) (0)
- Crystal structure of DmTailor in complex with U6 RNA (2018) (0)
- Crystal structure of the fluoroacetyl-CoA-specific thioesterase, FlK (2010) (0)
- Methods and compositions for modifying target DNA directed RNA and modulation of transcription directed RNA (2013) (0)
- Corrigendum: Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis. (2019) (0)
- Key role of an alpha-helical lid in driving the target DNA toward catalysis in CRISPR-Cas12a. (2023) (0)
- Karyopherin nuclear state (2009) (0)
- Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase (2020) (0)
- Crystal structure of the C-terminal RecA domain of DDX6 in complex with a conserved peptide from LSM14 (2018) (0)
- Uncut but Primed for Change. (2019) (0)
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What Schools Are Affiliated With Martin Jínek?
Martin Jínek is affiliated with the following schools:
