Martin Scheffner
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Computer Science
Martin Scheffner's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science Stanford University
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(Suggest an Edit or Addition)Martin Scheffner's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 (1990) (3982)
- The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53 (1993) (2364)
- Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade (1995) (965)
- A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. (1995) (912)
- Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex (2002) (857)
- A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. (1991) (855)
- The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. (1991) (846)
- Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53 (1993) (570)
- Activation of p53 by conjugation to the ubiquitin‐like protein SUMO‐1 (1999) (556)
- Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins (1993) (401)
- The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation (2005) (382)
- Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells (1998) (377)
- HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 (2003) (366)
- Interaction between ubiquitin–protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation (1999) (353)
- siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells (2003) (346)
- Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products. (1992) (287)
- RNA helicase activity associated with the human p68 protein (1989) (276)
- Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. (1994) (270)
- The Chaperone-associated Ubiquitin Ligase CHIP Is Able to Target p53 for Proteasomal Degradation* (2005) (262)
- Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects. (2014) (248)
- Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein. (2000) (244)
- The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme. (1998) (233)
- Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells. (2001) (212)
- Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells (2015) (206)
- A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. (1995) (194)
- Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue (2000) (188)
- Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7* (1998) (188)
- A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter (2003) (178)
- UBE1L2, a Novel E1 Enzyme Specific for Ubiquitin*♦ (2007) (171)
- Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system. (2003) (169)
- Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5 (*) (1996) (158)
- Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression (1993) (157)
- Tip60 is targeted to proteasome‐mediated degradation by Mdm2 and accumulates after UV irradiation (2002) (150)
- Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins (1992) (146)
- Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors (2002) (140)
- Role of the Histone Acetyl Transferase Tip60 in the p53 Pathway* (2004) (137)
- The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate. (1998) (132)
- Antibodies against Early Proteins of Human Papillomaviruses as Diagnostic Markers for Invasive Cervical Cancer (1998) (132)
- Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome* (1999) (128)
- The Ubiquitin-conjugating Enzymes UbcH7 and UbcH8 Interact with RING Finger/IBR Motif-containing Domains of HHARI and H7-AP1* (1999) (125)
- Functions of human papillomavirus proteins. (1994) (121)
- Targeted degradation of the retinoblastoma protein by human papillomavirus E7‐E6 fusion proteins. (1992) (118)
- Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc (2013) (116)
- RNA unwinding activity of SV40 large T antigen (1989) (111)
- HECT E3s and human disease (2007) (106)
- Ubiquitin, E6-AP, and their role in p53 inactivation. (1998) (101)
- Synthesis of defined ubiquitin dimers. (2010) (97)
- E6AP promotes the degradation of the PML tumor suppressor (2009) (95)
- Involvement of the DNA Repair Protein hHR23 inp53Degradation (2003) (95)
- Regulation of p27 Degradation and S-Phase Progression by Ro52 RING Finger Protein (2006) (88)
- Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome (2010) (83)
- Poly(ADP‐ribose)‐mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function (2014) (70)
- Mutation of HERC2 causes developmental delay with Angelman-like features (2012) (70)
- Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases. (2013) (69)
- Hetero-oligomerization with MdmX Rescues the Ubiquitin/Nedd8 Ligase Activity of RING Finger Mutants of Mdm2* (2007) (64)
- The Role of the Ubiquitin Ligase E6-AP in Human Papillomavirus E6-mediated Degradation of PDZ Domain-containing Proteins* (2007) (63)
- Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2* (2011) (62)
- Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. (2009) (59)
- Identification of Determinants in E2 Ubiquitin-conjugating Enzymes Required for hect E3 Ubiquitin-Protein Ligase Interaction* (1999) (57)
- E6-AP directs the HPV E6-dependent inactivation of p53 and is representative of a family of structurally and functionally related proteins. (1994) (54)
- Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53 (2005) (53)
- Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex (2018) (49)
- Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivo. (2000) (49)
- Cellular targets of the oncoproteins encoded by the cancer associated human papillomaviruses. (1991) (48)
- Recognition and Cleavage of Related to Ubiquitin 1 (Rub1) and Rub1-Ubiquitin Chains by Components of the Ubiquitin-Proteasome System* (2012) (47)
- Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation (2015) (46)
- Oncoproteins encoded by the cancer-associated human papillomaviruses target the products of the retinoblastoma and p53 tumor suppressor genes. (1991) (46)
- Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination (2015) (45)
- Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains. (2014) (45)
- Roles of larval sea urchin spicule SM50 domains in organic matrix self-assembly and calcium carbonate mineralization. (2013) (44)
- Generation of a Mono‐ubiquitinated PCNA Mimic by Click Chemistry (2011) (43)
- Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. (2007) (37)
- Ubiquitin ligase E6-AP and its role in human disease. (2008) (37)
- Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation (1998) (35)
- A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein (2009) (34)
- Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer. (2005) (32)
- Turning the RING Domain Protein MdmX into an Active Ubiquitin-Protein Ligase* (2010) (29)
- Identification of Proteins Interacting with Ubiquitin Chains. (2017) (29)
- The Ubiquitin Ligase HectH 9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation (2017) (29)
- c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity. (2013) (27)
- The ubiquitin–protein ligase activity of Hdm2 is inhibited by nucleic acids (2003) (27)
- Fluorogenic ATP analogues for online monitoring of ATP consumption: observing ubiquitin activation in real time. (2013) (25)
- Stabilization of Mineral Precursors by Intrinsically Disordered Proteins (2018) (23)
- Moving protein heads for breakdown (1999) (22)
- Fingerprinting differential active site constraints of ATPases (2013) (22)
- Ubiquitin Family Modifiers and the Proteasome (2012) (21)
- Sequence independent duplex DNA opening reaction catalysed by SV40 large tumor antigen. (1989) (21)
- Selective monitoring of the enzymatic activity of the tumor suppressor Fhit. (2014) (21)
- Improving bioorthogonal protein ubiquitylation by click reaction. (2013) (20)
- Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks. (2009) (20)
- Mechanisms of tumor suppressor protein inactivation by the human papillomavirus E6 and E7 oncoproteins (1994) (20)
- Towards a molecular basis of ubiquitin signaling: A dual-scale simulation study of ubiquitin dimers (2018) (19)
- Simian-virus-40 large-T-antigen-catalyzed DNA and RNA unwinding reactions. (1991) (15)
- On Biomineralization: Enzymes Switch on Mesocrystal Assembly (2019) (15)
- Effects of the antifungal agent ciclopirox in HPV‐positive cancer cells: Repression of viral E6/E7 oncogene expression and induction of senescence and apoptosis (2020) (15)
- UBE 1 L 2 , a Novel E 1 Enzyme Specific for Ubiquitin * (2007) (15)
- Formation of ubiquitin dimers via azide-alkyne click reaction. (2012) (13)
- Induction of apoptosis in human papillomavirus-positive cancer cells by peptide aptamers targeting the viral E 6 oncoprotein (12)
- Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere (2021) (11)
- Renaturation and DNA looping promoted by the SV40 large tumour antigen. (1990) (11)
- DNA binding properties and replication activity of the T antigen related D2 phosphoprotein. (1989) (10)
- Ubiquitin-fusion protein system: a powerful tool for ectopic protein expression in mammalian cells. (2009) (10)
- Formation of the Alarmones Diadenosine Triphosphate and Tetraphosphate by Ubiquitin- and Ubiquitin-like-Activating Enzymes. (2019) (9)
- Site-specific ubiquitylation acts as a regulator of linker histone H1 (2021) (9)
- The Length of a Ubiquitin Chain: A General Factor for Selective Recognition by Ubiquitin‐Binding Proteins (2020) (9)
- Assembly of branched ubiquitin oligomers by click chemistry. (2019) (8)
- Machine Learning Driven Analysis of Large Scale Simulations Reveals Conformational Characteristics of Ubiquitin Chains. (2020) (8)
- Structural and functional consequences of NEDD8 phosphorylation (2021) (7)
- Differentiation of Compact and Extended Conformations of Di-Ubiquitin Conjugates with Lysine-Specific Isopeptide Linkages by Ion Mobility-Mass Spectrometry (2011) (7)
- Ubiquitin, Ubiquitin-Like Proteins, and Proteasome-Mediated Degradation (2016) (6)
- Anionic surfactants enhance click reaction-mediated protein conjugation with ubiquitin. (2016) (6)
- Protein-DNA interactions at the simian virus 40 origin of replication. (1988) (6)
- Small‐Molecule Inhibitors of the Tumor Suppressor Fhit (2017) (6)
- SV40 T antigen catalyzed duplex DNA unwinding. (1989) (5)
- Erratum: A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase (Proceedings of the National Academy of Sciences of the United States of America (March 28, 1996) 92:7 (2563-2564)) (1995) (5)
- Artificially Linked Ubiquitin Dimers Characterised Structurally and Dynamically by NMR Spectroscopy (2019) (5)
- Study of adhesion and migration dynamics in ubiquitin E3A ligase (UBE3A)-silenced SYSH5Y neuroblastoma cells by micro-structured surfaces (2020) (4)
- Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants. (2020) (4)
- Oncogenic human papillomaviruses block expression of the B‐cell translocation gene‐2 tumor suppressor gene (2009) (4)
- Varshavsky's Contributions (2004) (4)
- Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate (2021) (4)
- Complete switch from Mdm 2 to human papillomavirus E 6-mediated degradation of p 53 in cervical cancer cells (2017) (3)
- Cell biology: Proteolytic relay comes to an end (2001) (3)
- Fluorescently Labelled ATP Analogues for Direct Monitoring of Ubiquitin Activation (2020) (3)
- A ubiquitin variant-based affinity approach selectively identifies substrates of the ubiquitin ligase E6AP in complex with HPV-11 E6 or HPV-16 E6 (2020) (3)
- Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4 (1999) (3)
- MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression. (2022) (3)
- Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53. (2010) (3)
- Tip 60 is targeted to proteasome-mediated degradation by Mdm 2 and accumulates after UV irradiation (2019) (3)
- Different Enzymatic Processing of γ‐Phosphoramidate and γ‐Phosphoester‐Modified ATP Analogues (2017) (3)
- Structural and Dynamic Characterization of Artificially LinkedUbiquitin Dimers by NMR spectroscopy (2019) (2)
- The interactome of site-specifically acetylated linker histone H1 (2021) (2)
- Generation and Characterization of Site‐Specifically Mono‐Ubiquitylated p53 (2022) (1)
- Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function (2022) (1)
- Fluorescent Cadmium Chalcogenide Nanoclusters in Ubiquitin (2020) (1)
- Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier (2020) (1)
- HECT Ubiquitin‐Protein Ligases in Human Disease (2007) (1)
- Interactome of Site-Specifically Acetylated Linker Histone H1. (2021) (0)
- Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex (2018) (0)
- Cover Picture: Dissecting Ubiquitin Signaling with Linkage‐Defined and Protease Resistant Ubiquitin Chains (Angew. Chem. Int. Ed. 47/2014) (2014) (0)
- The E6 oncoprotein of human papillomavirus 16 as a therapeutic target (2007) (0)
- On Biomineralization : Enzymes Switch on Crystallization (2018) (0)
- Validation and functional characterization of a novel Kif 18 A small molecule inhibitor (2010) (0)
- Effects of miRNAs of the miR-17~92 cluster on p21 expression in HeLa cells. (2015) (0)
- Functional DomainsofWild-Type andMutantp53Proteins Involved inTranscriptional Regulation, Transdominant Inhibition, andTransformation Suppression (1993) (0)
- Identification of a human ubiquitin-conjugating enzyme that mediates the E 6-AP-dependent ubiquitination of p 53 ( paplflomavirus / E 6-assodated protein / tumor-suppressor protein ) (0)
- Correction to Machine Learning Driven Analysis of Large Scale Simulations Reveals Conformational Characteristics of Ubiquitin Chains. (2020) (0)
- Localization oftheE6-APRegions ThatDirect Human Papillomavirus E6Binding, Association withp53,and Ubiquitination ofAssociated Proteins (1993) (0)
- 526. Conditionally Replicative Adenoviruses Designed to Restore Defects in the p53 Pathway for Effective Virotherapy of Cancer (2005) (0)
- Mineral Nucleation: Stabilization of Mineral Precursors by Intrinsically Disordered Proteins (Adv. Funct. Mater. 37/2018) (2018) (0)
- HRad23 is required for p53 degradation (2003) (0)
- Corrigendum: Generation of a Mono‐ubiquitinated PCNA Mimic by Click Chemistry (2011) (0)
- A human RNA ligase that operates via auto- and RNA-AMPylation (2022) (0)
- Identification of Novel Small Molecules Targeting the Protease Activity of Separase (2022) (0)
- Chemoproteomic discovery of a human RNA ligase (2023) (0)
- Analyse des „Ubiquitin-Codes“ mithilfe Protease-resistenter Ubiquitinketten (2015) (0)
- UBE3A (ubiquitin protein ligase E3A) (2011) (0)
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What Schools Are Affiliated With Martin Scheffner?
Martin Scheffner is affiliated with the following schools:
