Mary Ann Jordan
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Mary Ann Jordancomputer-science Degrees
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Engineering Computer Science
Mary Ann Jordan's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
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(Suggest an Edit or Addition)Mary Ann Jordan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Microtubules as a target for anticancer drugs (2004) (3936)
- Microtubule-binding agents: a dynamic field of cancer therapeutics (2010) (1385)
- Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. (1993) (1088)
- Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. (1996) (808)
- Microtubules and actin filaments: dynamic targets for cancer chemotherapy. (1998) (638)
- Mechanism of inhibition of cell proliferation by Vinca alkaloids. (1991) (569)
- Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis. (1992) (531)
- Taxol suppresses dynamics of individual microtubules in living human tumor cells. (1999) (526)
- Mechanism of action of antitumor drugs that interact with microtubules and tubulin. (2002) (426)
- The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth (2005) (425)
- Substoichiometric binding of taxol suppresses microtubule dynamics. (1995) (340)
- Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. (2010) (274)
- Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes. (1997) (271)
- How do microtubule-targeted drugs work? An overview. (2007) (266)
- Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics (2001) (256)
- βIII-Tubulin Induces Paclitaxel Resistance in Association with Reduced Effects on Microtubule Dynamic Instability* (2005) (239)
- Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine. (1993) (233)
- Microtubule dynamics: taking aim at a moving target. (1995) (215)
- Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells'. (2000) (183)
- Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase (2008) (183)
- Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy. (2013) (180)
- Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules (2010) (165)
- Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. (2001) (164)
- Vinblastine suppresses dynamics of individual microtubules in living interphase cells. (1995) (155)
- Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration. (2004) (154)
- Modulation of microtubule dynamics by drugs: a paradigm for the actions of cellular regulators. (1999) (148)
- Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells. (2005) (138)
- Mitotic block in HeLa cells by vinblastine: ultrastructural changes in kinetochore-microtubule attachment and in centrosomes. (1993) (135)
- Maytansinoid-Antibody Conjugates Induce Mitotic Arrest by Suppressing Microtubule Dynamic Instability (2010) (129)
- The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. (2003) (128)
- Suppression of microtubule dynamics by epothilone B is associated with mitotic arrest. (2003) (120)
- Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. (1985) (117)
- Ixabepilone: targeting βIII-tubulin expression in taxane-resistant malignancies (2009) (112)
- Interaction of vinblastine with steady-state microtubules in vitro. (1982) (111)
- Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. (2000) (110)
- Differential Effects of Vinblastine on Polymerization and Dynamics at Opposite Microtubule Ends* (1996) (110)
- Identification of a distinct class of vinblastine binding sites on microtubules. (1986) (102)
- The use and action of drugs in analyzing mitosis. (1999) (97)
- Pharmacological probes of microtubule function (1994) (97)
- Synergistic Suppression of Microtubule Dynamics by Discodermolide and Paclitaxel in Non-Small Cell Lung Carcinoma Cells (2004) (96)
- Microtubule Dynamics, Mitotic Arrest, and Apoptosis: Drug-Induced Differential Effects of βIII-Tubulin (2010) (94)
- Antiproliferative mechanism of action of cryptophycin-52: kinetic stabilization of microtubule dynamics by high-affinity binding to microtubule ends. (1998) (91)
- Phase dynamics at microtubule ends: the coexistence of microtubule length changes and treadmilling (1987) (89)
- Hesperidin suppressed proliferations of both Human breast cancer and androgen‐dependent prostate cancer cells (2010) (87)
- Kinetic stabilization of microtubule dynamics at steady state in vitro by substoichiometric concentrations of tubulin-colchicine complex. (1995) (87)
- FTDP-17 Mutations Compromise the Ability of Tau to Regulate Microtubule Dynamics in Cells* (2006) (87)
- Suppression of centromere dynamics by Taxol in living osteosarcoma cells. (2003) (86)
- Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833. (1995) (84)
- Use of drugs to study role of microtubule assembly dynamics in living cells. (1998) (84)
- Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations. (1990) (81)
- 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules (2006) (80)
- Mechanism of action of the unusually potent microtubule inhibitor cryptophycin 1. (1997) (76)
- Three- and Four-repeat Tau Regulate the Dynamic Instability of Two Distinct Microtubule Subpopulations in Qualitatively Different Manners (2005) (73)
- Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane. (2008) (72)
- In vitro pharmacology of cryptophycin 52 (LY355703) in human tumor cell lines (1999) (70)
- Antiproliferative Mechanism of Action of the Novel Taxane Cabazitaxel as Compared with the Parent Compound Docetaxel in MCF7 Breast Cancer Cells (2014) (68)
- Mitotic HeLa cells contain a CENP‐E‐associated minus end‐directed microtubule motor. (1995) (68)
- Modulation of CENP-E organization at kinetochores by spindle microtubule attachment. (1996) (62)
- New Microtubule / Tubulin-Targeted Anticancer Drugs and Novel Chemotherapeutic Strategies (2004) (60)
- Carbendazim Inhibits Cancer Cell Proliferation by Suppressing Microtubule Dynamics (2009) (58)
- Purification and Characterization of Native Conventional Kinesin, HSET, and CENP-E from Mitotic HeLa Cells* (2001) (56)
- Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation. (2003) (56)
- Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors. (2006) (51)
- Mechanism of action of the microtubule-targeted antimitotic depsipeptide tasidotin (formerly ILX651) and its major metabolite tasidotin C-carboxylate. (2007) (50)
- Interaction of the antitumor compound cryptophycin-52 with tubulin. (2000) (50)
- Low potency of taxol at microtubule minus ends: implications for its antimitotic and therapeutic mechanism. (1998) (50)
- Binding of vinblastine to stabilized microtubules. (1989) (48)
- Mechanism of microtubule assembly. Changes in polymer structure and organization during assembly of sea urchin egg tubulin. (1985) (47)
- Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. (1998) (44)
- Peripheral Neuropathy Induced by Microtubule-Targeted Chemotherapies: Insights into Acute Injury and Long-term Recovery. (2018) (43)
- Intrinsically Slow Dynamic Instability of HeLa Cell Microtubules in Vitro * (2002) (43)
- Erucin, the Major Isothiocyanate in Arugula (Eruca sativa), Inhibits Proliferation of MCF7 Tumor Cells by Suppressing Microtubule Dynamics (2014) (42)
- Contrasting roles of tau and microtubule-associated protein 2 in the vinblastine-induced aggregation of brain tubulin. (1984) (40)
- Effects of tetramethoxystilbene on hormone-resistant breast cancer cells: biological and biochemical mechanisms of action. (2007) (37)
- FTDP-17 Mutations in Tau Alter the Regulation of Microtubule Dynamics (2008) (37)
- Different reactivities of brain and erythrocyte tubulins toward a sulfhydryl group-directed reagent that inhibits microtubule assembly. (1985) (35)
- Characterization and detection of cellular and proteomic alterations in stable stathmin-overexpressing, taxol-resistant BT549 breast cancer cells using offgel IEF/PAGE difference gel electrophoresis. (2011) (34)
- Inhibition of mitosis and microtubule function through direct tubulin binding by a novel antiproliferative naphthopyran LY290181. (1997) (34)
- Determination of microtubule dynamic instability in living cells. (2010) (33)
- The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation (2014) (33)
- Quantitation of cellular tubulin in microtubules and tubulin pools by a competitive ELISA. (1991) (32)
- Mechanism of action of ixabepilone and its interactions with the βIII-tubulin isotype (2015) (32)
- Exploring the mechanisms of action of the novel microtubule inhibitor vinflunine. (2008) (32)
- Effects of novel taxanes SB-T-1213 and IDN5109 on tubulin polymerization and mitosis. (2002) (32)
- Mechanisms of inhibition of endothelial cell migration by taxanes (2014) (31)
- Interactions of Vinblastine and Maytansine with Tubulin a (1986) (30)
- Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization. (2004) (29)
- Microtubule assembly of isotypically purified tubulin and its mixtures. (2008) (29)
- Structural Basis for Induction of Peripheral Neuropathy by Microtubule-Targeting Cancer Drugs. (2016) (28)
- The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules. (2010) (27)
- Effects of Tau and MAP2 on the interaction of maytansine with tubulin: inhibitory effect of maytansine on vinblastine-induced aggregation of tubulin. (1985) (26)
- Effects of Paclitaxel and Eribulin in Mouse Sciatic Nerve: A Microtubule-Based Rationale for the Differential Induction of Chemotherapy-Induced Peripheral Neuropathy (2016) (24)
- A kinetic analysis of assembly-disassembly at opposite microtubule ends. (1982) (22)
- On the nonlinear relationship between the initial rates of dilution-induced microtubule disassembly and the initial free subunit concentration. (1983) (21)
- Effects of eribulin on microtubule binding and dynamic instability are strengthened in the absence of the βIII tubulin isotype. (2015) (20)
- Combinatorial Tau Pseudophosphorylation (2011) (19)
- Plinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling (2019) (18)
- Differential radiolabeling of opposite microtubule ends: methodology, equilibrium exchange-flux analysis, and drug poisoning. (1983) (16)
- Microtubule-Targeting Agents Eribulin and Paclitaxel Differentially Affect Neuronal Cell Bodies in Chemotherapy-Induced Peripheral Neuropathy (2017) (15)
- The interaction of cystamine with bovine brain tubulin. (1987) (14)
- βIII-tubulin enhances efficacy of cabazitaxel as compared with docetaxel (2017) (14)
- Erratum: Microtubule-binding agents: a dynamic field of cancer therapeutics (2010) (14)
- Differential Morphological and Biochemical Recovery from Chemotherapy-Induced Peripheral Neuropathy Following Paclitaxel, Ixabepilone, or Eribulin Treatment in Mouse Sciatic Nerves (2018) (12)
- Determination of drug binding to microtubules in vitro. (2010) (12)
- Removal of the projection domain of microtubule-associated protein 2 alters its interaction with tubulin (1994) (11)
- Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy. (2021) (10)
- Interaction of reduced glutathione with bovine brain tubulin. (1985) (10)
- A quantitative solid-phase binding assay for tubulin. (1993) (8)
- Microtubules as Targets for Anticancer Drugs, Both Tried and New (2010) (8)
- The effects of glutaraldehyde on the bound nucleotide content and morphology of microtubules in vitro. (1982) (7)
- Modeling the effects of drug binding on the dynamic instability of microtubules (2010) (6)
- Mono- and Disaccharides: Analytical Aspects (2006) (6)
- Assessing the utility of in vitro microtubule assays for studying mechanisms of peripheral neuropathy with the microtubule inhibitor class of cancer chemotherapy. (2019) (5)
- Temperature sensitivity of vinblastine-induced tubulin polymerization in the presence of microtubule-associated proteins (1992) (5)
- Mechanism of Assembly of Sea Urchin Egg Tubulin a (1986) (3)
- E7389 and ER-076349, synthetic halichondrin B analogs, suppress centromere dynamics in concert with mitotic block (2004) (3)
- Preclinical development of Aneustat (OMN54): a multifunctional multi-targeted natural product derivative with anti-tumor, anti-inflammatory and immuno-modulatory activity (2007) (2)
- CHAPTER 7 – INTERACTION OF VINBLASTINE WITH STEADY-STATE MICROTUBULES IN VITRO: MECHANISM OF INHIBITION OF NET TUBULIN ADDITION TO ASSEMBLY ENDS (1982) (2)
- Erratum (2010) (2)
- Maytansine derivatives and metabolites of antibody-maytansinoid conjugates inhibit microtubule polymerization and strongly suppress microtubule dynamics (2008) (2)
- The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation (2014) (1)
- Alkylating agents as probes for the binding of microtubule-associated proteins (MAPs) to tubulin (1982) (1)
- Imaging cellular microtubules with the atomic-force microscope (1992) (1)
- Abstract A300: Increased potency of the novel taxane cabazitaxel as compared with the parent compound docetaxel in MCF7 breast cancer cells. (2013) (1)
- Binding to Microtubules Conjugates Strongly Suppress Microtubule Dynamics by Maytansine and Cellular Metabolites of Antibody-Maytansinoid Updated (2010) (0)
- Discovery tansine and Cellular Metabolites of Antibody-tansinoid Conjugates Strongly Suppress Microtubule Ther amics by Binding to Microtubules (2010) (0)
- Abstract 772: Effects of natural products on proliferation of human breast cancer cells induced by estrogen or PhIP, a heterocyclic amine compound derived from cooked meat (2010) (0)
- Microtubule-Targeting Agents Eribulin and Paclitaxel Differentially Affect Neuronal Cell Bodies in Chemotherapy-Induced Peripheral Neuropathy (2017) (0)
- Abstract 5294: Inhibition of mitochondrial transport in neuronal cells by microtubule-targeting drugs eribulin, ixabepilone, paclitaxel, and vincristine (2014) (0)
- A Laboratory Investigation of 2,6-Diaminohexanoic Acid - An Essential Amino Acid in Euphorbia trigona (2017) (0)
- Suppression of microtubule dynamics by sulforaphane: A novel mechanistic basis for its antiproliferative action (2007) (0)
- Abstract 1666: Increased sensitivity of βIII tubulin-containing microtubules to cabazitaxel compared with docetaxel: A possible role of βIII tubulin in specifying good efficacy of cabazitaxel for docetaxel-resistant tumors (2015) (0)
- Cancer Biology and Signal Transduction Antiproliferative Mechanism of Action of the Novel Taxane Cabazitaxel as Compared with the Parent Compound Docetaxel in MCF 7 Breast Cancer Cells (2014) (0)
- Phytochemical Analysis of a Species of Mentha for Antibacterial Activity (2011) (0)
- Effects of Paclitaxel and Eribulin in Mouse Sciatic Nerve: A Microtubule-Based Rationale for the Differential Induction of Chemotherapy-Induced Peripheral Neuropathy (2015) (0)
- Abstract C213: Eribulin, vincristine, ixabepilone, and paclitaxel inhibit neuronal cell function by varied mechanisms and to varying degrees. (2011) (0)
- Differential Morphological and Biochemical Recovery from Chemotherapy-Induced Peripheral Neuropathy Following Paclitaxel, Ixabepilone, or Eribulin Treatment in Mouse Sciatic Nerves (2018) (0)
- Abstract C215: Depletion of the resistance-associated βIII tubulin isotype enhances eribulin's potency in suppressing microtubule dynamic instability and promotes inhibition of both microtubule growth and shortening. (2011) (0)
- Abstract 5464: Distinct effects of eribulin on axonal microtubule composition and modifications relative to paclitaxel, vincristine and ixabepilone in preclinical models: correlations with lower levels of eribulin-induced peripheral neuropathy (2014) (0)
- Abstract 5503: Microtubule-targeting agents induce differential myelinated axon degeneration in a mouse model of peripheral neuropathy (2014) (0)
- 419 Reduced Affinity of Eribulin for βIII-tubulin: a Role in Reduced Neuropathy? (2012) (0)
- The unusual mechanism of action of the microtubule targeted drug curacin A (2004) (0)
- P3-274 Tau, microtubule dynamics and neuronal cell death in tauopathies (2004) (0)
- Abstract #2701: Effects of paeoniflorin, baicalein, hesperidin and oleanolic acid on human breast and prostate cancer cells (2009) (0)
- Effects of taxol on microtubule dynamics in living human tumor cells. (1996) (0)
- Mechanism of assembly of sea urchin strongylocentrotus purpuratus egg tubulin (1982) (0)
- Effects of the isothiocyanates sulforaphane and erucin on breast cancer and normal human mammary epithelial cells. (2006) (0)
- apeutic Discovery tansinoid-Antibody Conjugates Induce Mitotic Arrest by Ther pressing Microtubule Dynamic Instability (2010) (0)
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