Mary Beckerle
#44,355
Most Influential Person Across History
American biologist and businessperson, CEO of Huntsman Cancer Institute at the University of Utah and corporate director at Johnson and Johnson
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Biology
Why Is Mary Beckerle Influential?
(Suggest an Edit or Addition)According to Wikipedia, Mary C. Beckerle is an American cell biologist who studies cancer at the Huntsman Cancer Institute at the University of Utah School of Medicine. At Huntsman Cancer Institute, she serves as the CEO and also as Associate Vice President for Cancer Affairs at the University of Utah. Beckerle's research helped to define a novel molecular pathway for cell motility, and more recently, she has begun research into Ewing’s sarcoma, a pediatric bone cancer. Beckerle's lab made a ground breaking discovery in regards to Ewing's Sarcoma in relation to the EWS/FLI protein. Her lab discovered EWS/FLI to disrupt the internal cellular skeleton, which decreases the ability of cells to adhere to their proper environment. This can help explain the metastasis of tumors in patients with Ewing's sarcoma.
Mary Beckerle's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage (1986) (1205)
- The LIM domain: from the cytoskeleton to the nucleus (2004) (723)
- Striated muscle cytoarchitecture: an intricate web of form and function. (2002) (649)
- The LIM domain is a modular protein-binding interface (1994) (476)
- Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement (2005) (372)
- Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton (1992) (330)
- Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion (1987) (279)
- Nuclear–Cytoplasmic Shuttling of the Focal Contact Protein, Zyxin: A Potential Mechanism for Communication between Sites of Cell Adhesion and the Nucleus (1997) (246)
- Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. (2003) (238)
- An interaction between zyxin and alpha-actinin (1992) (237)
- Zyxin: Zinc fingers at sites of cell adhesion (1997) (222)
- A Conserved LIM Protein That Affects Muscular Adherens Junction Integrity and Mechanosensory Function in Caenorhabditis elegans (1999) (213)
- A zyxin-mediated mechanism for actin stress fiber maintenance and repair. (2010) (200)
- Comparison of Three Members of the Cysteine-rich Protein Family Reveals Functional Conservation and Divergent Patterns of Gene Expression* (1997) (198)
- Adult mice deficient in actinin–associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy (2001) (186)
- Characterization of the Interaction between Zyxin and Members of the Ena/Vasodilator-stimulated Phosphoprotein Family of Proteins* (2000) (180)
- Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP (1994) (173)
- Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. (2000) (170)
- Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. (2005) (167)
- The Kindler Syndrome Protein Is Regulated by Transforming Growth Factor-β and Involved in Integrin-mediated Adhesion* (2004) (165)
- Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. (1991) (163)
- Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling (2006) (162)
- Targeting of Zyxin to Sites of Actin Membrane Interaction and to the Nucleus* (2001) (160)
- From the membrane to the nucleus and back again: bifunctional focal adhesion proteins. (2006) (137)
- Identification of a new protein localized at sites of cell-substrate adhesion (1986) (135)
- The LIM motif defines a specific zinc-binding protein domain. (1993) (132)
- Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth (2014) (131)
- CRP1, a LIM Domain Protein Implicated in Muscle Differentiation, Interacts with α-Actinin (1997) (126)
- Molecular Dissection of Zyxin Function Reveals Its Involvement in Cell Motility (1999) (125)
- Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains. (1998) (121)
- Members of the Zyxin Family of LIM Proteins Interact with Members of the p130Cas Family of Signal Transducers* (2002) (119)
- Spatial Control of Actin Filament Assembly Lessons from Listeria (1998) (119)
- Molecular Characterization of Human Zyxin* (1996) (118)
- The Cysteine-rich Protein Family of Highly Related LIM Domain Proteins * (1995) (116)
- Identification of talin as a major cytoplasmic protein implicated in platelet activation (1985) (115)
- Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes (2003) (113)
- Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton (1994) (110)
- Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators (2012) (108)
- Molecular dissection of a LIM domain. (1997) (102)
- Inhibitors of dynein activity block intracellular transport in erythrophores (1982) (99)
- Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration. (2002) (99)
- Targeted Disruption of the Murine zyxin Gene (2003) (97)
- LIM proteins in actin cytoskeleton mechanoresponse. (2014) (95)
- SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. (1996) (93)
- Structural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes. (1997) (92)
- Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets [published erratum appears in J Cell Biol 1990 Mar;110(3):865] (1989) (91)
- The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1 (2004) (88)
- The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. (1998) (87)
- Analysis of the role of microtubules and actin in erythrophore intracellular motility (1983) (83)
- Common metal ion coordination in LIM domain proteins. (1994) (80)
- The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma. (2012) (80)
- Talin: role at sites of cell-substratum adhesion. (1990) (75)
- Purification and Characterization of an α-Actinin-binding PDZ-LIM Protein That Is Up-regulated during Muscle Differentiation* (1999) (73)
- Characterization of RACK1 function in Drosophila development (2007) (73)
- Demonstration of a relationship between talin and P235, a major substrate of the calcium‐dependent protease in platelets (1986) (67)
- LIM Domains Target Actin Regulators Paxillin and Zyxin to Sites of Stress Fiber Strain (2013) (67)
- Supervillin modulation of focal adhesions involving TRIP6/ZRP-1 (2006) (67)
- Talin is a post-synaptic component of the rat neuromuscular junction. (1986) (64)
- Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis. (1999) (63)
- Two muscle-specific LIM proteins in Drosophila (1996) (63)
- Mechanical signals activate p38 MAPK pathway-dependent reinforcement of actin via mechanosensitive HspB1 (2017) (62)
- Mutational analysis of the metal sites in an LIM domain. (1994) (62)
- Structure of the cysteine-rich intestinal protein, CRIP. (1996) (61)
- TRIP6, a novel molecular partner of the MAGI‐1 scaffolding molecule, promotes invasiveness (2009) (61)
- The Rho/Rac-Family Guanine Nucleotide Exchange Factor VAV-1 Regulates Rhythmic Behaviors in C. elegans (2005) (60)
- The LIM protein, CRP1, is a smooth muscle marker (1999) (60)
- Mechanosensing through direct binding of tensed F-actin by LIM domains (2020) (58)
- Microinjected fluorescent polystyrene beads exhibit saltatory motion in tissue culture cells (1984) (52)
- A Novel Role for Keratin 17 in Coordinating Oncogenic Transformation and Cellular Adhesion in Ewing Sarcoma (2013) (51)
- Opposing Roles of Zyxin/LPP ACTA Repeats and the LIM Domain Region in Cell-Cell Adhesion* (2006) (50)
- Identification and subcellular location of talin in various cell types and tissues by means of [125I]vinculin overlay, immunoblotting and immunocytochemistry. (1988) (48)
- Identification of a CArG box-dependent enhancer within the cysteine-rich protein 1 gene that directs expression in arterial but not venous or visceral smooth muscle cells. (2001) (48)
- ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma. (2013) (47)
- Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma (2014) (46)
- The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity (2007) (45)
- Talin distribution and phosphorylation in thrombin-activated platelets. (1993) (43)
- The adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to a tumor-promoting phorbol ester. (1990) (42)
- LPP, a LIM protein highly expressed in smooth muscle. (2003) (42)
- Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation. (1999) (40)
- Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp‐1 (2006) (40)
- An Interaction between Zyxin and aActinin (1992) (39)
- LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function. (1998) (39)
- The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function (2008) (38)
- LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor. (1999) (37)
- A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton (2014) (37)
- Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response (2018) (36)
- The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. (2007) (36)
- The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis. (2010) (35)
- Quantitative measurement of proteins by western blotting with Cy5-coupled secondary antibodies. (1999) (34)
- ALP and MLP distribution during myofibrillogenesis in cultured cardiomyocytes. (2003) (34)
- Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets (1993) (33)
- The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. (2009) (31)
- Fine mapping of the α-actinin binding site within cysteine-rich protein (2000) (30)
- EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma (2015) (30)
- Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes (2020) (29)
- Fine mapping of the alpha-actinin binding site within cysteine-rich protein. (2000) (27)
- Loss of the Serum Response Factor Cofactor, Cysteine-Rich Protein 1, Attenuates Neointima Formation in the Mouse (2010) (26)
- Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β (2013) (22)
- Lateral communication between stress fiber sarcomeres facilitates a local remodeling response. (2012) (21)
- The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics (2017) (20)
- Expression of the Gene Encoding the LIM Protein CRP2: A Developmental Profile (2002) (20)
- A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted (2012) (19)
- Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled. (2003) (18)
- The Cytoskeletal Regulator Zyxin is Required for Viability in Drosophila melanogaster (2010) (16)
- Elevated Expression of the Integrin-Associated Protein PINCH Suppresses the Defects of Drosophila melanogaster Muscle Hypercontraction Mutants (2013) (14)
- Prognostic significance of PINCH signalling in human pancreatic ductal adenocarcinoma. (2010) (13)
- alpha-Actinin links LPP, but not zyxin, to cadherin-based junctions. (2008) (12)
- The Clone Wars – Revenge of the Metastatic Rogue State: The Sarcoma Paradigm (2011) (11)
- Regulated Membrane‐Cytoskeleton Linkages in Platelets a (1994) (11)
- Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility (2016) (11)
- Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation. (2011) (8)
- Mathematical Modeling of the Dynamic Mechanical Behavior of Neighboring Sarcomeres in Actin Stress Fibers (2014) (8)
- Medical Faculty Development: A Modern-Day Odyssey (2011) (7)
- Teaching Corporate in College (2014) (4)
- Blot Overlay Assay: A Method to Detect Protein–Protein Interactions (1994) (4)
- Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha (2020) (4)
- [7] Purification and assay of zyxin (1998) (3)
- PPPPS : EVH 1 domains and their proline-rich partners in cell polarity and migration (3)
- Adhesion, Signaling, and Cancer (2007) (3)
- Indirect immuno fluorescent and stereo high voltage electron microscopic evidence for micro tubule associated migration of pigment granules in erythrophores (1979) (3)
- Evidence that Ca++ and calmodulin control intracellular granule transport in Holocentrus erythrophores (1981) (2)
- Erratum: Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains (Molecular Biology of the Cell (1998) 9 (2157-2171)) (1999) (1)
- How Cell Biologists Can Contribute to Improving Cancer Outcomes (2010) (1)
- Cancer Therapy : Preclinical Reversible LSD 1 Inhibition Interferes with Global EWS / ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth (2014) (1)
- Purification and assay of zyxin. (1998) (1)
- Phosphorylation of the small heat shock protein HspB1 regulates cytoskeletal recruitment and cell motility (2022) (1)
- Reviewer List for 2002 (2002) (0)
- Activation dependent incorporation of gpiib iiia into the platelet cytoskeleton (1991) (0)
- A Focal Adhesion Protein Implicated In Tumor Progression Focal Adhesion Protein Implicated In Tumor Progression (2007) (0)
- Mathematical Modeling of the Dynamic Mechanical Behavior of Neighboring Sarcomeres in Actin Stress Fibers (2014) (0)
- Abstract 2366: Impact of EWS-FLI induced changes in gene expression and cell behavior on metastatic potential (2011) (0)
- Nuclear pore complexes concentrate on Actin/LINC/Lamin nuclear lines in response to mechanical stress in a SUN1 dependent manner (2022) (0)
- Mechanosensitivity of Actin Turnover Allows Cells to Maintain Homeostasis against Myosin-II Contractile Fluctuations in the Cytoskeleton (2016) (0)
- A genetic analysis of female pheromonal effects on PMSG-induced ovulation in immature mice. (1974) (0)
- Addenda (1888) (0)
- III. Focal adhesions as stress sensors III. Focal adhesions as stress sensors (2006) (0)
- The LIM motif: A specific zinc-binding protein domain (1993) (0)
- Adhesion in Ewing Sarcoma Oncogenic Transformation and Cellular A Novel Role for Keratin 17 in Coordinating (2014) (0)
- Airway Smooth Muscle Resolidification Following Stretch Is Dependent On Zyxin (2012) (0)
- Abstract 5134: Mechanistic dissection of EWS-FLI impact on Ewing's sarcoma cell behavior (2010) (0)
- A Erythrophore Intracellular Motility and Actin in (2003) (0)
- CYSTEINE RICH INTESTINAL PROTEIN, NMR, 48 STRUCTURES (1996) (0)
- ANALYZING MECHANISMS BY WHICH RSU1 SUPPRESSES ANCHORAGE INDEPENDENT CELL GROWTH IN TRANSFORMED MAMMALIAN CELLS (2015) (0)
- Cytoskeletal membrane organization at fibroblast focal contacts (1985) (0)
- Airway smooth muscle resolidification after stretch, but not static contractile force, is dependent on zyxin (2013) (0)
- SOLUTION STRUCTURE OF THE CHICKEN CRP1 (1999) (0)
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