Masaharu Takigawa

Masaharu Takigawa's AcademicInfluence.com Rankings

Masaharu Takigawa

Computer Science

#7990

World Rank

#8407

Historical Rank

Computational Linguistics

#1701

World Rank

#1719

Historical Rank

Machine Learning

#3144

World Rank

#3183

Historical Rank

Artificial Intelligence

#3445

World Rank

#3495

Historical Rank

computer-science Degrees

Download Badge

Computer Science

Masaharu Takigawa's Degrees

PhD Computer Science University of Tokyo
Masters Computer Science University of Tokyo
Bachelors Computer Science University of Tokyo

Similar Degrees You Can Earn

Why Is Masaharu Takigawa Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Masaharu Takigawa's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis (2007) (486)
Role and interaction of connective tissue growth factor with transforming growth factor‐β in persistent fibrosis: A mouse fibrosis model (1999) (467)
Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo. (1999) (405)
Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. (1998) (270)
Proposal for a unified CCN nomenclature (2003) (249)
Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis. (2004) (247)
Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. (2000) (243)
Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes. (1989) (234)
Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF. (2001) (193)
Effects of CTGF/Hcs24, a hypertrophic chondrocyte‐specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro (2000) (183)
Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis. (2004) (183)
Novel Transcription Factor-Like Function of Human Matrix Metalloproteinase 3 Regulating the CTGF/CCN2 Gene (2008) (179)
Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA. (1997) (176)
Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1. (1999) (176)
Role of CTGF/HCS24/ecogenin in skeletal growth control (2003) (174)
Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells. (1998) (167)
Pathogenic Role of Connective Tissue Growth Factor (CTGF/CCN2) in Osteolytic Metastasis of Breast Cancer (2006) (162)
CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK). (2001) (158)
Effects of CTGF/Hcs24, a Product of a Hypertrophic Chondrocyte-Specific Gene, on the Proliferation and Differentiation of Chondrocytes in Culture1. (2000) (152)
CCN Proteins: A New Family of Cell Growth And Differentiation Regulators (2005) (151)
Regeneration of Defects in Articular Cartilage in Rat Knee Joints by CCN2 (Connective Tissue Growth Factor) (2004) (149)
Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. (2011) (149)
Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2). (1990) (147)
Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3'-kinase signaling pathway. (2005) (139)
Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture. (2000) (138)
Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases. (2002) (137)
Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions. (2015) (135)
Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor. (1998) (134)
Increased Connective Tissue Growth Factor Relative to Brain Natriuretic Peptide as a Determinant of Myocardial Fibrosis (2007) (132)
CCN family proteins and angiogenesis: from embryo to adulthood (2006) (130)
Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia. (1998) (129)
Hepatocyte growth factor counteracts transforming growth factor‐β1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice (2003) (128)
Expression of neurotrophins and their receptors (TRK) during fracture healing. (2000) (124)
CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin α5β1 (2006) (124)
Increased expression of connective tissue growth factor in the infarct zone of experimentally induced myocardial infarction in rats. (1998) (122)
Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine biosynthesis by alpha-difluoromethylornithine. (1983) (117)
Chondrocytes Are Regulated by Cellular Adhesion Through CD44 and Hyaluronic Acid Pathway (1997) (116)
Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro. (1998) (115)
Nitric oxide mediates interleukin-1-induced matrix degradation and basic fibroblast growth factor release in cultured rabbit articular chondrocytes: a possible mechanism of pathological neovascularization in arthritis. (1996) (113)
CTGF/Hcs24, a hypertrophic chondrocyte‐specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes (2002) (110)
Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8). (1998) (108)
Connective tissue growth factor causes persistent proα2(I) collagen gene expression induced by transforming growth factor‐β in a mouse fibrosis model (2005) (107)
Cooperative Regulation of Chondrocyte Differentiation by CCN2 and CCN3 Shown by a Comprehensive Analysis of the CCN Family Proteins in Cartilage (2008) (106)
Polyamine and differentiation: induction of ornithine decarboxylase by parathyroid hormone is a good marker of differentiated chondrocytes. (1980) (104)
Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge. (1994) (104)
Involvement of CTGF, a Hypertrophic Chondrocyte-Specific Gene Product, in Tumor Angiogenesis (2001) (102)
Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver. (2014) (101)
Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy (2008) (100)
Role of CCN2/CTGF/Hcs24 in bone growth. (2007) (100)
CTGF/Hcs24, hypertrophic chondrocyte‐specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes (2003) (98)
Expression of connective tissue growth factor in cartilaginous tumors (2000) (97)
Effects of parathyroid hormone and cyclic AMP analogues on the activity of ornithine decarboxylase and expression of the differentiated phenotype of chondrocytes in culture (1981) (97)
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine. (1982) (94)
Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure (2008) (92)
Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment (2018) (91)
Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line. (2001) (88)
Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets. (2004) (88)
Adenovirus vector-mediated gene transduction to chondrocytes: in vitro evaluation of therapeutic efficacy of transforming growth factor-beta 1 and heat shock protein 70 gene transduction. (1997) (87)
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. (2008) (86)
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes (2007) (84)
Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. (1990) (83)
Regulation of chondrocytic phenotype by micro RNA 18a: Involvement of Ccn2/Ctgf as a major target gene (2009) (83)
CTGF/Hcs24 as a multifunctional growth factor for fibroblasts, chondrocytes and vascular endothelial cells. (2003) (82)
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5 (2008) (81)
Changes in parathyroid hormone receptors during chondrocyte cytodifferentiation. (1994) (78)
CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1. (2006) (75)
Regulation of human COL2A1 gene expression in chondrocytes. Identification of C-Krox-responsive elements and modulation by phenotype alteration. (2000) (74)
Hydrostatic pressure induces expression of interleukin 6 and tumour necrosis factor α mRNAs in a chondrocyte-like cell line (1998) (73)
Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis. (2006) (72)
Mechanical Stimulation Induces CTGF Expression in Rat Osteocytes (2001) (71)
Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes (2014) (70)
CCN2: a master regulator of the genesis of bone and cartilage (2013) (70)
A Repetitive, Steady Mouth Opening Induced an Osteoarthritis-like Lesion in the Rabbit Temporomandibular Joint (2003) (70)
Insulin-Like Growth Factors I and II Are Autocrine Factors in Stimulating Proteoglycan Synthesis, a Marker of Differentiated Chondrocytes, Acting through Their Respective Receptors on a Clonal Human Chondrosarcoma-Derived Chondrocyte Cell Line, HCS-2/8. (1997) (69)
CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell–specific transmembrane protein (DC‐STAMP) (2011) (69)
Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model. (2005) (69)
Differential roles of CCN family proteins during osteoblast differentiation: Involvement of Smad and MAPK signaling pathways. (2011) (69)
The role of CCN2 in cartilage and bone development (2011) (66)
Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes (2006) (65)
Establishment from a human chondrosarcoma of a new immortal cell line with high tumorigenicity in vivo, which is able to form proteoglycan‐rich cartilage‐like nodules and to respond to insulin in vitro (1991) (65)
Adenovirus mediated gene delivery to the joints of guinea pigs. (1998) (65)
Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage. (2004) (64)
Effect of DL-α-hydrazino-δ-aminovaleric acid, an inhibitor of ornithine decarboxylase, on polyamine metabolism in isoproterenol-stimulated mouse parotid glands (1975) (63)
Tumor Necrosis Factor α Induces Expression of Genes for Matrix Degradation in Human Chondrocyte‐like HCS‐2/8 Cells Through Activation of NF‐κB: Abrogation of the Tumor Necrosis Factor α Effect by Proteasome Inhibitors (2001) (61)
Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. (2001) (60)
cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure. (2002) (60)
Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing. (2002) (60)
Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritis (2001) (60)
N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan. (2009) (59)
Simulation of the initial stage of endochondral ossification: in vitro sequential culture of growth cartilage cells and bone marrow cells. (1981) (59)
Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line. (2003) (58)
miRNA-720 Controls Stem Cell Phenotype, Proliferation and Differentiation of Human Dental Pulp Cells (2013) (58)
Possible Roles of CTGF/Hcs24 in the Initiation and Development of Ossification of the Posterior Longitudinal Ligament (2002) (57)
Chondrocytes dedifferentiated by serial monolayer culture form cartilage nodules in nude mice. (1987) (56)
Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3′-untranslated region interacting with a cellular protein in human chondrosarcoma cells (2006) (56)
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes. (2006) (56)
Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells (2018) (55)
Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells (2005) (55)
Regulatory mechanism of human connective tissue growth factor (CTGF/Hcs24) gene expression in a human chondrocytic cell line, HCS-2/8. (2001) (54)
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids of patients with temporomandibular joint osteoarthritis. (2000) (53)
Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade. (2002) (53)
Mouse Meckel's cartilage chondrocytes evoke bone‐like matrix and further transform into osteocyte‐like cells in culture (1996) (52)
Autoimmunity against YKL-39, a human cartilage derived protein, in patients with osteoarthritis. (2002) (52)
CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling (2012) (51)
CCN2 enhances RANKL-induced osteoclast differentiation via direct binding to RANK and OPG. (2015) (50)
The CCN family acting throughout the body: recent research developments (2013) (49)
Role of LRP1 in transport of CCN2 protein in chondrocytes (2012) (49)
Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: Similarities to retroviral RNA-protein interactions (2000) (49)
Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus. (2013) (49)
Stimulation by glucocorticoids of the differentiated phenotype of chondrocytes and the proliferation of rabbit costal chondrocytes in culture. (1985) (48)
Ex vivo gene delivery using an adenovirus vector in treatment for cartilage defects. (2000) (48)
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. (2008) (48)
Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-β produced by tubular epithelial cells in response to high glucose (2005) (48)
CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase‐type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells (2002) (48)
Vegetarian diet ameliorates symptoms of atopic dermatitis through reduction of the number of peripheral eosinophils and of PGE2 synthesis by monocytes. (2001) (47)
Connective tissue growth factor expressed in rat alveolar bone regeneration sites after tooth extraction. (2003) (47)
CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition. (2009) (47)
Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes. (2011) (47)
CCN family 2/connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes. (2008) (46)
Connective tissue growth factor mRNA expression pattern in cartilages is associated with their type I collagen expression. (2003) (46)
Differential effects of 1 alpha,25-dihydroxycholecalciferol and 24R,25-dihydroxycholecalciferol on the proliferation and the differentiated phenotype of rabbit costal chondrocytes in culture. (1988) (46)
Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins (2017) (46)
Expression and physiological role of CCN4/Wnt‐induced secreted protein 1 mRNA splicing variants in chondrocytes (2007) (45)
Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development (2004) (45)
Purification of an angiogenesis inhibitor from culture medium conditioned by a human chondrosarcoma-derived chondrocytic cell line, HCS-2/8. (1995) (45)
Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones. (2007) (44)
Involvement of cis‐acting repressive element(s) in the 3′‐untranslated region of human connective tissue growth factor gene (1999) (44)
Identity of Urinary Trypsin Inhibitor-binding Protein to Link Protein* (2000) (44)
Dexamethasone induces connective tissue growth factor expression in renal tubular epithelial cells in a mouse strain-specific manner. (2006) (44)
CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Has Anti-Aging Effects That Protect Articular Cartilage from Age-Related Degenerative Changes (2013) (43)
Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA. (2011) (42)
Novel intracellular effects of human connective tissue growth factor expressed in Cos‐7 cells (2000) (42)
UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage–specific manner (2017) (42)
Immunohistochemical localization of connective tissue growth factor in the rat central nervous system (1999) (42)
Cytoskeleton and differentiation: effects of cytochalasin B and colchicine on expression of the differentiated phenotype of rabbit costal chondrocytes in culture. (1984) (41)
CTGF and Apoptosis in Mouse Osteocytes Induced by Tooth Movement (2009) (41)
Differential effects of parathyroid hormone and somatomedin-like growth factors on the sizes of proteoglycan monomers and their synthesis in rabbit costal chondrocytes in culture. (1985) (41)
Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells. (2010) (40)
Proto‐oncogene Expression in a Human Chondrosarcoma Cell Line: HCS‐2/8 (1994) (39)
Overexpression of c-erbB-3 in Various Stages of Human Squamous Cell Carcinomas (1998) (39)
Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer (2020) (39)
Low-intensity pulsed ultrasound (LIPUS) treatment of cultured chondrocytes stimulates production of CCN family protein 2 (CCN2), a protein involved in the regeneration of articular cartilage: mechanism underlying this stimulation. (2017) (37)
E6-AP/UBE3A Protein Acts as a Ubiquitin Ligase toward SOX9 Protein* (2013) (37)
Studies on Chondrocytes from Mandibular Condylar Cartilage, Nasal Septal Cartilage, and Spheno-occipital Synchondrosis in Culture. I. Morphology, Growth, Glycosaminoglycan Synthesis, and Responsiveness to Bovine Parathyroid Hormone (1-34) (1984) (37)
Interleukin-4 downregulates the cyclic tensile stress-induced matrix metalloproteinases-13 and cathepsin B expression by rat normal chondrocytes. (2008) (36)
Characterization of a mouse ctgf 3'-UTR segment that mediates repressive regulation of gene expression. (2000) (35)
Cartilage–Specific Over-Expression of CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Stimulates Insulin-Like Growth Factor Expression and Bone Growth (2013) (35)
Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study. (2003) (34)
Kunitz-type Protease Inhibitor Bikunin Disrupts Phorbol Ester-induced Oligomerization of CD44 Variant Isoforms Containing Epitope v9 and Subsequently Suppresses Expression of Urokinase-type Plasminogen Activator in Human Chondrosarcoma Cells* (2002) (34)
Possible role of LRP1, a CCN2 receptor, in chondrocytes. (2006) (34)
Effects of synthetic analogs and fragments of bovine parathyroid hormone on adenosine 3',5'-monophosphate level, ornithine decarboxylase activity, and glycosaminoglycan synthesis in rabbit costal chondrocytes in culture: structure-activity relations. (1985) (34)
Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice. (2007) (33)
Downregulation of rheumatoid arthritis‐related antigen RA‐A47 (HSP47/colligin‐2) in chondrocytic cell lines induces apoptosis and cell‐surface expression of RA‐A47 in association with CD9 (2005) (33)
Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family (2013) (33)
Comparable response of ccn1 with ccn2 genes upon arthritis: An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines (2005) (32)
Novel role of miR‐181a in cartilage metabolism (2013) (32)
Prostaglandin E2 downregulates TNF‐α‐induced production of matrix metalloproteinase‐1 in HCS‐2/8 chondrocytes by inhibiting Raf‐1/MEK/ERK cascade through EP4 prostanoid receptor activation (2007) (32)
Enhanced responsiveness to parathyroid hormone and induction of functional differentiation of cultured rabbit costal chondrocytes by a pulsed electromagnetic field. (1987) (32)
Nicotine-induced CCN2: from Smoking to Periodontal Fibrosis (2010) (32)
Role of the low‐density lipoprotein receptor‐related protein‐1 in regulation of chondrocyte differentiation (2010) (32)
Proinsulin C-peptide Regulates Ribosomal RNA Expression* (2009) (32)
Physiological role of vitamin A in growth cartilage cells: low concentrations of retinoic acid strongly promote the proliferation of rabbit costal growth cartilage cells in culture. (1990) (32)
Novel chondrogenic and chondroprotective effects of the natural compound harmine. (2013) (32)
Low-energy diet in atopic dermatitis patients: clinical findings and DNA damage. (2000) (32)
Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene. (2006) (32)
Histatin as a synergistic stimulator with epidermal growth factor of rabbit chondrocyte proliferation. (1994) (31)
Transcriptional induction of connective tissue growth factor/hypertrophic chondrocyte-specific 24 gene by dexamethasone in human chondrocytic cells. (2003) (31)
THE CCN FAMILY OF PROTEINS: AN OVERVIEW (2005) (31)
Role of polyamines in expression of the differentiated phenotype of chondrocytes: effect of DL-alpha-hydrazino-delta-aminovaleric acid (DL-HAVA), an inhibitor of ornithine decarboxylase, on chondrocytes treated with parathyroid hormone. (1983) (31)
Expression of c‐fos gene inhibits proteoglycan synthesis in transfected chondrocyte (1996) (30)
Effects of tensile and compressive strains on response of a chondrocytic cell line embedded in type I collagen gel. (2008) (30)
High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis. (2002) (30)
Isolation and characterization of a rheumatoid arthritis-specific antigen (RA-A47) from a human chondrocytic cell line (HCS-2/8). (1998) (30)
Expression of neurotrophins and their receptors tropomyosin-related kinases (Trk) under tension-stress during distraction osteogenesis. (2006) (29)
The regenerative effects of CCN2 independent modules on chondrocytes in vitro and osteoarthritis models in vivo. (2014) (29)
Mechanical stretch increases Smad3‐dependent CCN2 expression in inner meniscus cells (2012) (29)
Changes in polyamine metabolism of rat liver after administration of D-galactosamine. Favorable effects of putrescine administration on galactosamine-induced hepatic injury. (1979) (29)
The Effect of Parathyroid Hormone (1-34) on Cyclic AMP Level, Ornithine Decarboxylase Activity, and Glycosaminoglycan Synthesis of Chondrocytes from Mandibular Condylar Cartilage, Nasal Septal Cartilage, and Spheno-occipital Synchondrosis in Culture (1987) (29)
Characterization of Binding Properties of Urinary Trypsin Inhibitor to Cell-associated Binding Sites on Human Chondrosarcoma Cell Line HCS-2/8* (2001) (29)
A novel cis-element that enhances connective tissue growth factor gene expression in chondrocytic cells. (2002) (29)
Novel effects of CCN3 that may direct the differentiation of chondrocytes (2011) (28)
CD44 stimulation by fragmented hyaluronic acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells. (2002) (28)
Scrotal angiokeratoma in a young man. (1996) (28)
Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer (2020) (28)
Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: role of pro-apoptotic Bid. (2014) (28)
Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3 (2020) (28)
Effects of various growth and differentiation factors on expression of parathyroid hormone receptors on rabbit costal chondrocytes in culture. (1991) (28)
Molecular characterisation of integrin-procollagen C-propeptide interactions. (1997) (28)
Cationic polymer-mediated genetic transduction into cultured human chondrosarcoma-derived HCS-2/8 cells (2001) (27)
Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in culture. (2006) (27)
Promotion of Hydroxyapatite-Associated, Stem Cell-Based Bone Regeneration by CCN2 (2008) (27)
Conformation dependence of integrin-type II collagen binding Inability of collagen peptides to support α 2 β 1 binding , and mediation of adhesion to denatured collagen by a novel α 5 β 1-fibronectin bridge (27)
Novel mode of processing and secretion of connective tissue growth factor/ecogenin (CTGF/Hcs24) in chondrocytic HCS-2/8 cells. (2001) (27)
Module-specific antibodies against human connective tissue growth factor: utility for structural and functional analysis of the factor as related to chondrocytes. (2004) (27)
A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes. (2012) (26)
Posttranscriptional Regulation of Chicken ccn2 Gene Expression by Nucleophosmin/B23 during Chondrocyte Differentiation (2008) (26)
Fluocinolone Acetonide Is a Potent Synergistic Factor of TGF‐β3–Associated Chondrogenesis of Bone Marrow–Derived Mesenchymal Stem Cells for Articular Surface Regeneration (2015) (26)
The role of putrescine in cell proliferation of the skin of mice induced by ethylphenylpropriolate. (1977) (26)
Tumor necrosis factor alpha induces expression of genes for matrix degradation in human chondrocyte-like HCS-2/8 cells through activation of NF-kappaB: abrogation of the tumor necrosis factor alpha effect by proteasome inhibitors. (2001) (26)
Roles of heterotypic CCN2/CTGF–CCN3/NOV and homotypic CCN2–CCN2 interactions in expression of the differentiated phenotype of chondrocytes (2012) (26)
Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling. (2008) (25)
Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel (2008) (25)
Expression of transduced HSP70 gene protects chondrocytes from stress. (2001) (25)
Role of polyamines in expression of the differentiated phenotype of chondrocytes in culture. (1981) (25)
Regulation of Chicken ccn2 Gene by Interaction between RNA cis-Element and Putative trans-Factor during Differentiation of Chondrocytes* (2005) (25)
Induction by parathyroid hormone of ornithine decarboxylase in rabbit costal chondrocytes in culture. (1979) (24)
Demonstration of receptors for epidermal growth factor on cultured rabbit chondrocytes and regulation of their expression by various growth and differentiation factors. (1992) (24)
CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function. (2016) (24)
Expression of trkC in a mouse osteoblastic cell line and its response to neurotrophin-3. (1994) (24)
Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes: possible regenerative roles in articular cartilage metabolism. (2005) (23)
Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage (2005) (23)
Gene Expression and Distribution of Connective Tissue Growth Factor (CCN2/CTGF) During Secondary Ossification Center Formation (2007) (23)
Effect of transforming growth factor-beta1 on expression of the connective tissue growth factor (CCN2/CTGF) gene in normal human gingival fibroblasts and periodontal ligament cells. (2009) (22)
CCN2 as a Novel Molecule Supporting Energy Metabolism of Chondrocytes (2014) (22)
Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells. (2008) (22)
Low‐intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling (2018) (22)
Control of delivered gene expression in chondrocytes using heat shock protein 70B promoter. (1999) (21)
Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24/CCN2) during distraction osteogenesis (2004) (21)
Inhibition of tumor-stromal interaction through HGF/Met signaling by valproic acid. (2008) (21)
Tyrosine kinase‐type receptor ErbB4 in chondrocytes: interaction with connective tissue growth factor and distribution in cartilage (2002) (21)
Rheumatoid arthritis-related antigen 47 kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47 (2000) (21)
The difference between the effects of single and double applications of 12-O-tetradecanoylphorbol-13-acetate, a potent tumor promoter, on polyamine metabolism and nucleic acid synthesis in mouse epidermis. (1983) (21)
Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells (2006) (21)
The CCN Proteins: An Overview. (2017) (21)
Change in cellular localization of a rheumatoid arthritis‐related antigen (RA‐A47) with downregulation upon stimulation by inflammatory cytokines in chondrocytes (2001) (20)
CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts. (2015) (20)
TGF-beta1 and HGF coordinately facilitate collagen turnover in subepithelial mesenchyme. (2002) (20)
Direct adenovirus-mediated gene delivery to the temporomandibular joint in guinea-pigs. (1999) (20)
An early history of CCN2/CTGF research: the road to CCN2 via hcs24, ctgf, ecogenin, and regenerin (2018) (20)
Promotion of attachment of human bone marrow stromal cells by CCN2. (2007) (20)
A hydrophobic protein, chargerin II, purified from rat liver mitochondria is encoded in the unidentified reading frame A6L of mitochondrial DNA. (1988) (19)
Cartilage-derived anti-tumor factor (CATF) inhibits the proliferation of endothelial cells in culture. (1985) (19)
Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis (2017) (19)
Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage (2017) (19)
Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress (2012) (19)
Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs. (2004) (18)
Demonstration of receptors for parathyroid hormone on cultured rabbit costal chondrocytes. (1989) (18)
Downregulation of a rheumatoid arthritis‐related antigen (RA‐A47) by ra‐a47 antisense oligonucleotides induces inflammatory factors in chondrocytes (2003) (18)
Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel. (2008) (18)
Meckel's cartilage chondrocytes in organ culture synthesize bone-type proteins accompanying osteocytic phenotype expression (2004) (18)
Tumor promoter-induced refractory state against ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis. (1986) (18)
Hydrocortisone stimulation of proliferation and glycosaminoglycan synthesis in rabbit craniofacial chondrocytes in vitro. (1988) (18)
Demonstration of endothelin (ET) receptors on cultured rabbit chondrocytes and stimulation of DNA synthesis and calcium influx by ET‐1 via its receptors (1995) (18)
Restoration by parathyroid hormone and dibutyryl cyclic AMP of expression of the differentiated phenotype of chondrocytes inhibited by a tumor promoter, 12-0-tetradecanoylphorbol-13-acetate. (1983) (17)
Stimulatory effects of 4-methylcatechol, dopamine and levodopa on the expression of metallothionein-III (GIF) mRNA in immortalized mouse brain glial cells (VR-2g) (1998) (17)
A reporter system evaluates tumorigenesis, metastasis, β-catenin/MMP regulation, and druggability. (2019) (17)
Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells. (2004) (17)
Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines. (2007) (16)
Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation. (2008) (16)
YKL-39, a human cartilage-related protein, induces arthritis in mice. (2002) (16)
Expression of osteopontin in Meckel’s cartilage cells during phenotypic transdifferentiation in vitro, as detected by in situ hybridization and immunocytochemical analysis (1998) (16)
Interaction of AP-1 and the ctgf gene: a possible driver of chondrocyte hypertrophy in growth cartilage (2003) (16)
Cbfa1/Runx2 gene expression in articular chondrocytes of the mice temporomandibular and knee joints in vivo. (2003) (16)
Gene expression profile of human chondrocyte HCS-2/8 cell line by EST sequencing analysis. (2004) (16)
Distribution, gene expression, and functional role of EphA4 during ossification. (2008) (16)
Matrix remodeling response of human periodontal tissue cells toward fibrosis upon nicotine exposure (2014) (16)
Immunochemical study of role of chargerin II, a product of URFA6L of mitochondrial DNA in energy transduction of rat liver mitochondria. (1987) (15)
Pachyonychia congenita type 2: keratin 17 mutation in a Japanese case. (1998) (15)
Molecular phenotyping of HCS-2/8 cells as an in vitro model of human chondrocytes. (2004) (15)
Association of the metastatic phenotype with CCN family members among breast and oral cancer cells (2011) (14)
Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma. (2008) (14)
Coordinated change between complement C1s production and chondrocyte differentiation in vitro (1997) (13)
Methylation status of EXT1 and EXT2 promoters and two mutations of EXT2 in chondrosarcoma. (2005) (13)
Cell Density-Dependent Proliferative Effects of Transforming Growth Factor (TGF)-β1, β2, and β3 in Human Chondrosarcoma Cells HCS-2/8 Are Associated with Changes in the Expression of TGF-β Receptor Type I (2001) (13)
Physiological role of urothelial cancer‐associated one long noncoding RNA in human skeletogenic cell differentiation (2018) (13)
Mitogenic Effects of Neurotrophins on a Periodontal Ligament Cell Line (2001) (13)
Possible reparative effect of low-intensity pulsed ultrasound (LIPUS) on injured meniscus (2018) (13)
Triphenyltetrazolium and its derivatives are anisotropic inhibitors of energy transduction in oxidative phosphorylation in rat liver mitochondria. (1983) (13)
Physical interaction of CCN2 with diverse growth factors involved in chondrocyte differentiation during endochondral ossification (2015) (13)
Conserved Repressive Regulation of Connective Tissue Growth Factor/Hypertrophic Chondrocyte-Specific Gene 24 (ctgf/hcs24) Enabled by Different Elements and Factors among Vertebrate Species (2003) (12)
Comparison of inhibition by a tumor promoter (12-O-tetradecanoylphorbol-13-acetate) of expression of the differentiated phenotype of chondrocytes in rabbit costal chondrocytes in culture with inhibition by retinoic acid. (1986) (12)
Differentiation and de-differentiation of cultured chondrocytes: increase in monomeric size of 'cartilage-specific' proteoglycans by dibutyryl cyclic AMP and complete inhibition of their synthesis by retinoic acid. (1985) (12)
Induction of spermidine/spermine N1-acetyltransferase by parathyroid hormone in rabbit costal chondrocytes in culture. (1985) (12)
A clonal human chondrosarcoma cell line produces an anti-angiogenic antitumor factor. (1990) (12)
Peripheral type benzodiazepine receptor in T lymphocyte rich preparation. (1998) (12)
Promoter Analyses of CCN Genes. (2017) (12)
Insulin-like growth factors I and II are autocrine factors in stimulating proteoglycan synthesis, a marker of differentiated chondrocytes, acting through their respective receptors on a clonal human chondrosarcoma-derived chondrocyte cell line, HCS-2/8. (1997) (12)
Direct interaction between CCN family protein 2 and fibroblast growth factor 1 (2014) (12)
Mechanical stretch increases CCN2/CTGF expression in anterior cruciate ligament-derived cells. (2011) (12)
Regeneration of defects in the articular cartilage in rat knee joints by connective tissue growth factor hypertrophic chondrocyte-specific gene product 24 CCN family member 2 (CTGF/Hcs24/CCN2). (2004) (12)
Apoptosis in normal skin. (1995) (11)
CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi (2018) (11)
All-trans retinoic acid-induced ADAM28 degrades proteoglycans in human chondrocytes. (2009) (11)
A factor in conditioned medium of rabbit costal chondrocytes inhibits the proliferation of cultured endothelial cells and angiogenesis induced by B16 melanoma: its relation with cartilage-derived anti-tumor factor (CATF). (1987) (10)
Effects of tumor necrosis factor α on proliferation and expression of differentiated phenotypes in rabbit costal chondrocytes in culture (1990) (10)
Thrombopoietic-mesenchymal interaction that may facilitate both endochondral ossification and platelet maturation via CCN2 (2009) (10)
Metabolic regulation of the CCN family genes by glycolysis in chondrocytes (2018) (10)
Roles of CCN2/CTGF in the control of growth and regeneration. (2005) (10)
CTGF/CCN2 facilitates LRP4‐mediated formation of the embryonic neuromuscular junction (2020) (10)
Vitamin D inhibits endothelial cell migration (1996) (10)
Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT2A and 5-HT2B receptors in chondrocytes (2017) (10)
A Tumor Suppressor Gene Product, Platelet‐Derived Growth Factor Receptor‐Like Protein Controls Chondrocyte Proliferation and Differentiation (2017) (10)
Differential expression of vascular endothelial growth factor in high- and low-metastasis cell lines of salivary gland adenoid cystic carcinoma. (2014) (10)
The BMP-2 mutant L51P: a BMP receptor IA binding-deficient inhibitor of noggin (2019) (9)
Neurotrophin-3 increases the DNA-binding activities of several transcription factors in a mouse osteoblastic cell line. (1996) (9)
CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage (2020) (9)
Purified hydrophobic proteins, chargerins, are essential for energy transduction in oxidative phosphorylation. (1985) (9)
Novel enzyme-linked immunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): detection of HTLV-I tax-induced CTGF from a human carcinoma cell line. (2003) (9)
Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-α expression upon lipopolysaccharide stimulation in human monocytes. (2015) (9)
Role of CCN2 in Amino Acid Metabolism of Chondrocytes (2016) (9)
CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes. (2002) (9)
The Basic Effect of IGF on Chondrocytes (1997) (9)
A coding RNA segment that enhances the ribosomal recruitment of chicken ccn1 mRNA (2010) (8)
Regulation of cellular communication factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis. (2020) (8)
Selective Agonists of Nuclear Retinoic Acid Receptor Gamma Inhibit Growth of HCS‐2/8 Chondrosarcoma Cells (2019) (8)
CCN3-mediated promotion of sulfated proteoglycan synthesis in rat chondrocytes from developing joint heads (2011) (8)
Novel Transcriptional Regulation of CCN2/CTGF by Nuclear Translocation of MMP3 (2010) (8)
Restoration by cyclic AMP of the differentiated phenotype of chondrocytes from de-differentiated cells pretreated with retinoids (1982) (7)
Novel FNR homologues identified in four representative oral facultative anaerobes: Capnocytophaga ochracea, Capnocytophaga sputigena, Haemophilus aphrophilus, and Actinobacillus actinomycetemcomitans. (1996) (7)
Senile lip licking. (1995) (6)
Suppression of adipocyte differentiation by low‐intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2 (2020) (6)
Adenovirus vector-mediated gene transduction to chondrocytes (1998) (6)
Increased Levels of CTGF mRNA Expression in a Murine Model of Allergic Airway Inflammation (2005) (6)
RFX1‐mediated CCN3 induction that may support chondrocyte survival under starved conditions (2021) (6)
Induction of hepatocyte growth factor expression by maleic acid in human fibroblasts through MAPK activation (2008) (6)
Retinoids as Inhibitors of Tumor Promotion1 (1985) (6)
Effects of various tumor promoters on expression of cartilage phenotypes in rabbit costal chondrocytes in culture. (1987) (6)
CTGF (connective tissue growth factor) (2011) (6)
New functional aspects of CCN2 revealed by trans-omic approaches (2015) (6)
Detection of specific antibodies against human cultured chondrosarcoma (HCS-2/8) and osteosarcoma (Saos-2) cells in the serum of patients with osteoarthritis of the temporomandibular joint. (1999) (5)
Specific serum antibodies against membranous proteins of a human immortal chondrocytic cell line (HCS-2/8) in rheumatoid arthritis and their relationship to the natural history of this disease (1996) (5)
Observations on the mechanism of skin tumor promotion by phorbol esters. (1983) (5)
Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus type I Tax protein. (2001) (5)
Correction: Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions. (2015) (5)
Design and utility of CCN2 anchor peptide aptamers. (2010) (5)
Cartilaginous differentiation in the joint capsule (1999) (5)
Regulation of CCN1 via the 3′-untranslated region (2013) (5)
Roles of matricellular CCN2 deposited by osteocytes in osteoclastogenesis and osteoblast differentiation (2019) (5)
[The role of osteocytes in bone remodeling.] (2017) (4)
Involvement of multiple CCN family members in platelets that support regeneration of joint tissues (2016) (4)
[CCN family genes in the development and differentiation of cartilage tissues]. (2006) (4)
Effect of DL-alpha-hydrazino-delta-aminovaleric acid, an inhibitor of ornithine decarboxylase, on polyamine metabolism in isoproterenol-stimulated mouse parotid glands. (1975) (4)
Cell density-dependent proliferative effects of transforming growth factor (TGF)-beta 1, beta 2, and beta 3 in human chondrosarcoma cells HCS-2/8 are associated with changes in the expression of TGF-beta receptor type I. (2001) (4)
Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells. (2019) (4)
Production of Recombinant CCN2 Protein by Mammalian Cells. (2017) (4)
Roles of Interaction between CCN2 and Rab14 in Aggrecan Production by Chondrocytes (2020) (4)
Purification of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase from mouse epidermis. (1983) (4)
[Physiological function of connective tissue growth factor (CTGF/Hcs24)--its roles in the process of endochondral ossification]. (1999) (3)
Report on the fourth international workshop on the CCN family of genes (2007) (3)
CCN2/CTGF has anti-aging effects to protect articular cartilage from age-related degenerative changes (2009) (3)
Proinsulin C-peptide regulates ribosomal RNA expression. (2017) (3)
The human chondrosarcoma HCS-2/8 cell line is responsive to BMP-7, but not to IL-1beta. (2005) (3)
Report on the 7th international workshop on the CCN family of genes (2014) (3)
Fibroblast Growth Factors and Cellular Communication Network Factors: Intimate Interplay by the Founding Members in Cartilage (2022) (2)
Mobile fat; three stages? (1996) (2)
CCN proteins in health and disease: An overview of the fifth international workshop on the CCN family of genes (2010) (2)
Terminology of CCN1-6 should not be applicable for their fragments and be limited to only full length CCN1-6 (2015) (2)
Cell Biological Assays for Measuring Angiogenic Activities of CCN Proteins. (2017) (2)
Extracellular Oncosomes Rich in Moonlighting Metalloproteinase (MMP3) Are Transmissive, Pro-Tumorigenic, and Induces Cellular Communication Network Factor 2 (CCN2/CTGF): CRISPR against Cancer (2020) (2)
Evaluation of Molecular Interaction between CCN2 Protein and Its Binding Partners by Surface Plasmon Resonance (SPR). (2017) (2)
Cytoskeleton and the Differentiated Phenotype of Chondrocytes in Culture (1983) (2)
In Vivo Evaluation of Cartilage Regenerative Effects of CCN2 Protein. (2017) (2)
Cartilage derived anti-tumor factor(CATF) : A high morecular weight in cartilage extract inhibits tumor growth. (1984) (2)
Establishment from mouse growth cartilage of clonal cell lines with responsiveness to parathyroid hormone, alkaline phosphatase activity, and ability to produce an endothelial cell growth inhibitor (1989) (2)
Fifth International Workshop on the CCN Family of Genes: Abstracts and Posters October 18–22, 2008 (2008) (1)
Inhibition of polyamine synthesis and proliferation in mouse L cells by DL-alpha-hydrazino-delta-aminovaleric acid, an inhibitor of ornithine decarboxylase. (1983) (1)
CCN Proteins (2017) (1)
Generation and Analysis of Cartilage-Specific CCN2 Overexpression in Transgenic Mice. (2017) (1)
Clinical Significance and Pathogenic Function of Connective Tissue Growth Factor ( CTGF / CCN 2 ) in Osteolytic Mandibular Squamous Cell Carcinoma (2009) (1)
Cartilage-derived anti-tumor factor (CATF) (1988) (1)
Development of Dentin Regeneration Therapy : Expression of Type I Collagen and Alkaline Phosphatase Induced by CTGF in Human Cultured Dental Pulp (2002) (1)
Preparation of Module-Specific Antibodies Against CCN Family Members. (2017) (1)
Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3 and Reducing STAT3 (2020) (1)
Effect of Angiotensin II on Chondrocyte Degeneration and Protection via Differential Usage of Angiotensin II Receptors (2021) (1)
Sorcin Expression in the Epiphyseal Growth Plates of Mice (2016) (1)
Electrophoretic and serologic characterization of 56 kDa antigen (M56) with autologous serum derived from a chondrosarcoma patient: A shared antigen of immunoresponses in cancer and autoimmune diseases (1999) (1)
Novel methods for the study of cell-collagen interactions. (1991) (1)
CCN Proteins in Health and Disease (2010) (1)
Western Blotting Analysis of CCN Proteins in Calcified Tissues. (2017) (1)
Immunohistochemical Analysis of CCN Proteins in Calcified Tissues. (2017) (1)
Protocols for Screening for Binding Partners of CCN Proteins: Yeast Two-Hybrid System. (2017) (1)
Bipartite regulation of cellular communication network factor 2 and fibroblast growth factor 1 genes by fibroblast growth factor 1 through histone deacetylase 1 and fork head box protein A1 (2021) (1)
Report on the 7(th) international workshop on the CCN family of genes : October 16-19, 2013-Nice, France. (2014) (1)
Protocols for Screening Peptide Motifs Binding to CCN Family Proteins. (2017) (1)
Driving the driver: Molecular regulation of CTGF/Hcs24/CCN2, a factor that regulates chondrocyte growth and differentiation (2003) (1)
Novel pathogenic role of fibrin as revealed by a case study on ligneous gingivitis (2011) (1)
Effect of pressure loading on interleukin-8 production in chondrocytes (1999) (1)
Erratum: Proinsulin C-peptide regulates ribosomal RNA expression (The Journal of Biological Chemistry (2010) 285 (3462-3469) DOI: 10.1074/jbc.M109.053587) (2017) (1)
Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing (2022) (1)
Assessment of CCN2 Independent Modules Regenerative Capacity on Osteoarthritis and Further Selecting the Most Suitable Among them as a Potential Therapeutic Drug (2016) (0)
Activation of NF-(kappa)B by TNF(alpha) in human chondrosarcoma HCS-2/8 cells (1998) (0)
E6-AP/UBE3A Acts as a Ubiquitin Ligase toward SOX9 (2013) (0)
Expression and Regulation of an Antisense RNA Transcript of the Human Connective Tissue Growth Factor Gene in Human Tumour Cells (2006) (0)
Abstract 1860: Plasma Connective Tissue Growth Factor is a Potential Marker of Diastolic Function and Myocardial Fibrosis in Patients with Chronic Heart Failure (2006) (0)
Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family (2012) (0)
Expression andiilterozyuosity of imprinting 1gf-ii and hiv in the human chondrosarcoma-dbrivbd CHI.I.S. IICS-2/8 and -2 A (1997) (0)
Studies on the role of polyamines in the proliferation of mouse epidermis (Japanese) (1976) (0)
Erratum: Effects of various growth and differentiation factors on expression of parathyroid hormone receptors on rabbit coastal chondrocytes in culture (Endocrinology 129: 868-876, 1991) (1991) (0)
Hypoxic induction of CCN2 mRNA through p38 MAP kinase activation in the human chondrosarcoma‐derived cell line, HCS‐2/8 (2020) (0)
[Anti-tumor factors in cartilage]. (1987) (0)
Micro RNA 18a regulates chondrocytic phenotype: Involvement of Ccn2/Ctgf as a major target gene (2009) (0)
Roles of interaction between CCN2 and Rab14 in vesicle trafficking in osteocytes and chondrocytes (2017) (0)
Metabolic regulation of CCN family genes that integrate extracellular signals (2017) (0)
[Cartilage and mechanical stress from the point of the view of development, growth, pathology and therapeutic aspects]. (2004) (0)
Cell Biological Assays for Measuring Chondrogenic Activities of CCN2 Protein. (2017) (0)
Cartilage-derived Antitumor Factor (CATF) (1984) (0)
Nucleophosmin / B 23 : A Multifunctional Regulator That Determines the Fate of CCN 2 mRNA (2010) (0)
CCN2 induces osteoclastogenesis by regulating RANK/RANKL/OPG system (2014) (0)
Introduction for CCN proteins. (2005) (0)
CCN2: a master regulator of the genesis of bone and cartilage (2013) (0)
Subject Index Vol. 191,1995 (1995) (0)
Mouse Models of Tumor Bone Metastasis and Invasion for Studying CCN Proteins. (2023) (0)
In Vitro Transfection with and Expression of CCN Family of Genes. (2017) (0)
Cardiac Myocytes Regulates Collagen Production Through Connective Tissue Growth Factor Secretion Induced by Various Neurohumoral Factors(Molecular Biology, Myocardium 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society) (2005) (0)
Protocols for Screening Peptides Binding to CCN Family Proteins and Their Extended Utility. (2023) (0)
The Balance of Connective Tissue Growth Factor and Brain Natriuretic Peptide Regulates Myocardial Fibrosis and Stiffness (2005) (0)
Effects of 12-0-tetradecanoylphorbol-13-acetate on the Differentiated Phenotype of Chondrocytes in Rabbit Costal Chondrocytes in Culture (1984) (0)
Subject Index Vol. 61, 2001 (2001) (0)
Production of Nano-Sized Exosomes by Fibrogenic Cells of the Liver or Pancreas: Role in Intercellular Delivery of Pro-Fibrotic Molecules and Potential as Novel Drug Delivery Agents In Vivo (2014) (0)
Angiogenesis Assays for the Analysis of CCN Proteins. (2023) (0)
An early history of CCN2/CTGF research: the road to CCN2 via hcs24, ctgf, ecogenin, and regenerin (2017) (0)
Expression of vasohibin-1 (VASH1) and its significance in endochondral ossification (2017) (0)
Contact dermatitis from carboxyvinyl polymer (1995) (0)
Terminology of CCN1-6 should not be applicable for their fragments and be limited to only full length CCN1-6 (2015) (0)
Cooperative Regulation of Cell Proliferation and Differentiation by CCN2 and CCN3 (2010) (0)
A bioassay for parathyroid hormone using rabbit costal chondrocytes in culture. (1983) (0)
Gene Expression Analysis of CCN Proteins: Whole-Mount In Situ Hybridization of Ccn2 in Developing Calcified Tissues. (2017) (0)
The new application of chip technology to transcriptome and proteome analysis of rheumatoid disease (2003) (0)
Cloning of a mRNA preferentially expressed in chondrocytes by differential display- PCR: Identity with connective tissue growth factor (CTGF) mRNA (1997) (0)
Metabolic regulation of the CCN family genes by glycolysis in chondrocytes (2017) (0)
The effect of LIPUS treatment on osteoclastogenesis (2017) (0)
Cellular Fluorescence Imaging for the Evaluation of Bioactivity of CCN Family Proteins. (2023) (0)
The role of IL-4 in the control of mechanical stress-induced inflammatory mediators by rat chondrocytes (2003) (0)
Analysis of Transcytosis of CCN2 by Chondrocytes. (2017) (0)
Gene Delivery to Chondrocytes Using Adenovirus Vector (1999) (0)
Physical interaction of CCN2 with diverse growth factors involved in chondrocyte differentiation during endochondral ossification (2015) (0)
Possible reparative effect of low-intensity pulsed ultrasound (LIPUS) on injured meniscus (2018) (0)
Analysis of Pathological Activities of CCN Proteins in Bone Metastasis. (2017) (0)
Effects of Fibroblast Growth Factor 1 (FGF‐1) on CCN2 Gene Expression in Chondrocytic Cells (2019) (0)
Matrix remodeling response of human periodontal tissue cells toward fibrosis upon nicotine exposure (2014) (0)
Influence of hydrostatic pressure on expression of heat shock protein 70 and matrix synthesis in chondrocytes (1996) (0)
Development of The Dentin Regeneration Therapy-Expression of Type1 collagen and ALP induced by CTGF in human cultured dental pulp- (2002) (0)
Scrotal angiokeratoma in a young man. (1996) (0)
Parathyroid Hormone-Responsive Clonal Cell Lines from Mouse Growth Cartilage (1989) (0)
Erratum: Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells (Journal of Biological Chemistry (2002) 277 (8022 (2002) (0)
Bipartite regulation of cellular communication network factor 2 and fibroblast growth factor 1 genes by fibroblast growth factor 1 through histone deacetylase 1 and fork head box protein A1 (2021) (0)
Novel targets for cancer and connective tissues diseases: A meeting sponsored by the International CCN Society (2011) (0)
REGULATION OF BIGLYCAN AND DECORIN SYNTHESIS BY CONNECTIVE TISSUE GROWTH FACTOR IN CULTURED BOVINE AORTIC ENDOTHELIAL CELLS (2002) (0)
Analysis of Expression of CCN Family Genes in Skeletal Tissue-Derived Cells. (2017) (0)
A novel regulatory factor in osteoclastogenesis DCL-1/CD302: significance of its binding to CCN2/CTGF (2016) (0)
Analysis of Signaling Pathways Activated by CCN Proteins. (2017) (0)
Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress (2012) (0)
Function of CD302 in osteoclast maturation and its interaction with CCN2 (2016) (0)
[Establishment of clonal cell lines producing cartilage-derived anti-tumor factor (CATF)]. (1988) (0)
The Evaluation of Meniscus Regenerative Effects of LIPUS-Induced CCN Proteins: Induction by LIPUS of CCN2 and Meniscus-Related Genes in Cultured Meniscus Cells and Meniscus Tissues. (2023) (0)
Do not overwork: cellular communication network factor 3 for life in cartilage. (2023) (0)
Repression of antiproliferative factor Tob 1 in osteoarthritic cartilage (2015) (0)
[Role of polyamines in expression of the differentiated phenotype of chondrocytes in culture (author's transl)]. (1981) (0)
Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis (2017) (0)
ELISA of CCN Family Proteins in Body Fluids Including Serum and Plasma. (2017) (0)
Regeneration of defects in the articular cartilage in rat knee joints by connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) (2003) (0)
Evaluation of the Molecular Interaction Between CCN Protein and Its Binding Partners: A Solid-Phase Binding Assay and Surface Plasmon Resonance. (2023) (0)
Analysis of Posttranscriptional Regulation of CCN Genes. (2017) (0)
[Autoantigen and molecular chaperone in rheumatoid arthritis--their roles in metabolism of chondrocytes]. (2006) (0)
The Gene Expressions of Connective Tissue Growth Factor and Brain Natriuretic Peptide are Coordinately Regulated in Cardiac Myocytes (2005) (0)
Stimulation by hydrocortisone of the differentiated phenotype of chondrocytes and the proliferation of chondrocytes from rabbit craniofacial complex in culture (1985) (0)
CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi (2018) (0)
Establishment of an in vitro cell derived from human angiosarcoma. (1996) (0)
Increase of CCN2 expression and production in cultured human meniscus cells and rat meniscus by LIPUS (2017) (0)
Dopamine Receptor Presence in the Rat Area Postrema Identified by RT-PCR, Immunohistochemistry, and In Situ Hybridization (2007) (0)
CTGF EXPRESSION IS SENSITIVE TO CHANGES OF THE ACTIN CYTOSKELETON IN ENDOTHELIAL CELLS (2005) (0)
Catabolic effects of fibroblast growth factor-1 on chondrocytes through matrix metalloproteinase-13 and connective tissue growth factor/CCN2: possible role in osteoarthritis (2018) (0)
Nucleophosmin/B23: A Multifunctional Regulator that Determines the Fate of CCN2 mRNA (2010) (0)
- Difluoromethylornithine α Promoter-stimulated Epidermal Polyamine Biosynthesis by Inhibition of Mouse Skin Tumor Promotion and of Updated Version (2006) (0)
Regulation of CCN1 via the 3′-untranslated region (2013) (0)
Analyses of the Posttranscriptional Regulation of CCN Genes: Approach to Multiple Steps of CCN2 Gene Expression. (2023) (0)
Imaging of Molecular Interaction Between CCN Protein and Its Binding Partners: An In Situ Proximity Ligation Assay of Interaction Between CCN2 and Rab14 in Chondrocytes. (2023) (0)
OP-JBIO140060 1..10 (2014) (0)
Production of Recombinant CCN2 Protein in Escherichia coli. (2017) (0)
MATRICRINE AND MMPs (2001) (0)
Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes (2014) (0)
Direct interaction between CCN family protein 2 and fibroblast growth factor 1 (2014) (0)
CCN Proteins (Cellular Communication Network Factors): Expanding Their Repertoire Toward a New Concept. (2023) (0)
Protein Imaging of CCN2 and CCN3 in Living Cells. (2017) (0)
Possible role of Ccn family members during osteoblast differentiation (2010) (0)
Novel Cell Biological Assays for Measuring Bone Remodeling Activities of CCN Proteins. (2023) (0)
Contents, Vol. 191, 1995 (1995) (0)
Fourth international workshop on the CCN family of genes: Abstracts and posters October 18–21, 2006 (2007) (0)
Contents Vol. 61, 2001 (2001) (0)
Is atopic dermatitis related to the month of birth (1995) (0)
Chondrocytes highly express CCN3 with age, and its overexpression promotes cartilage aging (2019) (0)
Acknowledgment to Referees for Dermatology 1995 (1995) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Masaharu Takigawa?

Masaharu Takigawa is affiliated with the following schools:

Masaharu Takigawa's Academic­Influence.com Rankings

Masaharu Takigawa's Degrees

Similar Degrees You Can Earn

Why Is Masaharu Takigawa Influential?

Masaharu Takigawa's Published Works

Published Works

What Schools Are Affiliated With Masaharu Takigawa?

Masaharu Takigawa's AcademicInfluence.com Rankings