Matt Kaeberlein
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American biologist
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Matt Kaeberleinbiology Degrees
Biology
#2219
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#3550
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#998
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Cell Biology
#280
World Rank
#288
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#56
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Molecular Biology
#417
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#425
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#142
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Biology
Matt Kaeberlein's Degrees
- PhD Molecular and Cellular Biology University of Washington
- Bachelors Biochemistry University of Washington
Why Is Matt Kaeberlein Influential?
(Suggest an Edit or Addition)According to Wikipedia, Matt Kaeberlein is an American biologist and biogerontologist best known for his research on evolutionarily conserved mechanisms of aging. He is currently a professor of pathology at the University of Washington in Seattle.
Matt Kaeberlein's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase (2000) (3230)
- The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. (1999) (2145)
- mTOR is a key modulator of ageing and age-related disease (2013) (1343)
- Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients (2005) (1260)
- Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration (2002) (1059)
- Extension of chronological life span in yeast by decreased TOR pathway signaling. (2006) (931)
- Substrate-specific Activation of Sirtuins by Resveratrol* (2005) (748)
- Aging, natural death, and the compression of morbidity. (1980) (694)
- Absence of effects of Sir2 over-expression on lifespan in C. elegans and Drosophila (2011) (606)
- Histone H4 lysine-16 acetylation regulates cellular lifespan (2009) (589)
- Replicative and chronological aging in Saccharomyces cerevisiae. (2012) (509)
- Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4 (2008) (443)
- Sir2-Independent Life Span Extension by Calorie Restriction in Yeast (2004) (440)
- mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome (2013) (415)
- Elimination of replication block protein Fob1 extends the life span of yeast mother cells. (1999) (390)
- The TOR pathway comes of age. (2009) (354)
- A molecular mechanism of chronological aging in yeast (2009) (328)
- Lessons on longevity from budding yeast (2010) (324)
- Lifespan extension in Caenorhabditis elegans by complete removal of food (2006) (321)
- Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival (2012) (303)
- Replicative aging in yeast: the means to the end. (2008) (268)
- Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf‐1‐dependent mechanism in Caenorhabditis elegans (2008) (252)
- Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice (2016) (244)
- Recent Developments in Yeast Aging (2007) (242)
- Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans (2009) (232)
- Dietary restriction and lifespan: Lessons from invertebrate models (2017) (225)
- Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae (2011) (210)
- Quantitative evidence for conserved longevity pathways between divergent eukaryotic species. (2008) (203)
- Healthy aging: The ultimate preventative medicine (2015) (200)
- A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. (2015) (195)
- Measuring Caenorhabditis elegans Life Span on Solid Media (2009) (180)
- Ruminations on dietary restriction and aging (2007) (173)
- Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. (2012) (171)
- Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans (2014) (168)
- Ribosome Deficiency Protects Against ER Stress in Saccharomyces cerevisiae (2012) (168)
- H3K36 methylation promotes longevity by enhancing transcriptional fidelity (2015) (167)
- Genes determining yeast replicative life span in a long-lived genetic background (2005) (167)
- Measuring Replicative Life Span in the Budding Yeast (2009) (161)
- High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction (2002) (142)
- Molecular mechanisms underlying genotype‐dependent responses to dietary restriction (2013) (136)
- Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. (2002) (133)
- Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans (2008) (132)
- Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast (2005) (131)
- Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity (2008) (124)
- A method for high-throughput quantitative analysis of yeast chronological life span. (2008) (119)
- Sirtuin‐independent effects of nicotinamide on lifespan extension from calorie restriction in yeast (2006) (117)
- Sir2 and calorie restriction in yeast: A skeptical perspective (2007) (114)
- Lessons on longevity from budding yeast (2010) (110)
- Longevity and aging (2013) (108)
- A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs (2017) (105)
- Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span (2015) (104)
- The Sensitivity of Yeast Mutants to Oleic Acid Implicates the Peroxisome and Other Processes in Membrane Function (2007) (103)
- The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. (2001) (102)
- Rapamycin and Alzheimer’s disease: Time for a clinical trial? (2019) (101)
- A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan (2013) (99)
- HIF‐1 modulates longevity and healthspan in a temperature‐dependent manner (2011) (98)
- Resveratrol and rapamycin: are they anti‐aging drugs? (2010) (94)
- The dog aging project: translational geroscience in companion animals (2016) (93)
- Biochemical Genetic Pathways that Modulate Aging in Multiple Species. (2015) (92)
- The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1 (2013) (90)
- Correction: Corrigendum: Transcription errors induce proteotoxic stress and shorten cellular lifespan (2015) (89)
- WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis (2013) (88)
- A genomic analysis of chronological longevity factors in budding yeast (2011) (88)
- How healthy is the healthspan concept? (2018) (86)
- Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import (2014) (84)
- Large-scale identification in yeast of conserved ageing genes (2005) (82)
- Modulating mTOR in aging and health. (2015) (79)
- Quantifying yeast chronological life span by outgrowth of aged cells. (2009) (79)
- Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response (2014) (75)
- Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging (2013) (74)
- Why Is Aging Conserved and What Can We Do about It? (2015) (72)
- Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction" (2006) (71)
- Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. (2014) (70)
- Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice (2015) (69)
- Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes (2008) (69)
- Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix (2011) (69)
- The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging (2010) (67)
- Hot topics in aging research: protein translation and TOR signaling, 2010 (2011) (67)
- Genome-wide identification of conserved longevity genes in yeast and worms (2007) (65)
- Composition and Acidification of the Culture Medium Influences Chronological Aging Similarly in Vineyard and Laboratory Yeast (2011) (65)
- Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1. (2013) (63)
- pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast (2012) (63)
- Microfluidic technologies for yeast replicative lifespan studies (2017) (63)
- The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. (2014) (61)
- Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. (2002) (61)
- Transcription errors induce proteotoxic stress and shorten cellular lifespan (2015) (60)
- A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer (2014) (59)
- Sir2 deletion prevents lifespan extension in 32 long‐lived mutants (2011) (58)
- Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans (2012) (57)
- Yeast replicative aging: a paradigm for defining conserved longevity interventions. (2014) (57)
- Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae (2013) (56)
- Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. (2004) (56)
- Midlife gene expressions identify modulators of aging through dietary interventions (2012) (55)
- Ageing: A midlife longevity drug? (2009) (54)
- Hot topics in aging research: protein translation, 2009 (2009) (53)
- The Enigmatic Role of Sir2 in Aging (2005) (51)
- Rapamycin treatment attenuates age-associated periodontitis in mice (2017) (51)
- Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans (2012) (50)
- mTOR Inhibition: From Aging to Autism and Beyond (2013) (49)
- The mitochondrial unfolded protein response and increased longevity: Cause, consequence, or correlation? (2014) (48)
- Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast (2011) (47)
- Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals “aging factors” and mechanism of lifespan asymmetry (2015) (47)
- YODA: Software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast (2010) (47)
- Protein translation, 2007 (2007) (45)
- Medicine: Grapes versus gluttony (2006) (44)
- by two different mechanisms Saccharomyces cerevisiae alone promote longevity in SIR 2 complex and SIR 2 / 3 / 4 The (1999) (43)
- Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics (2018) (43)
- Spermidine surprise for a long life (2009) (42)
- Regulation of mRNA translation as a conserved mechanism of longevity control. (2010) (42)
- Rapamycin enhances survival in a Drosophila model of mitochondrial disease (2016) (41)
- Attenuation of Age-Related Metabolic Dysfunction in Mice With a Targeted Disruption of the Cβ Subunit of Protein Kinase A (2009) (41)
- Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans (2017) (39)
- Rapamycin in aging and disease: maximizing efficacy while minimizing side effects (2016) (39)
- Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes (2017) (38)
- Rapamycin rejuvenates oral health in aging mice (2019) (38)
- Using yeast to discover the fountain of youth. (2001) (38)
- The hypoxic response and aging. (2009) (35)
- Antiaging diets: Separating fact from fiction (2021) (35)
- mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases. (2019) (35)
- Desexing Dogs: A Review of the Current Literature (2019) (35)
- A genetic screen for zygotic embryonic lethal mutations affecting cuticular morphology in the wasp Nasonia vitripennis. (2000) (33)
- AGEID: a database of aging genes and interventions (2002) (33)
- Translational geroscience: A new paradigm for 21st century medicine. (2017) (32)
- Rapamycin and ageing: when, for how long, and how much? (2014) (32)
- Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism (2014) (32)
- Preserving Youth: Does Rapamycin Deliver? (2013) (32)
- Age-associated vulval integrity is an important marker of nematode healthspan (2016) (31)
- Aging Is RSKy Business (2009) (31)
- Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span (2020) (30)
- A role for SIRT1 in the hypoxic response. (2010) (30)
- Protein translation, 2008 (2008) (30)
- Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast (2018) (29)
- The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19 (2021) (29)
- Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging (2017) (29)
- Yeast as a model to understand the interaction between genotype and the response to calorie restriction (2012) (28)
- WormBot, an open-source robotics platform for survival and behavior analysis in C. elegans (2019) (27)
- Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans (2015) (26)
- Oral health in geroscience: animal models and the aging oral cavity (2018) (26)
- Regional metabolic signatures in the Ndufs4(KO) mouse brain implicate defective glutamate/α-ketoglutarate metabolism in mitochondrial disease. (2020) (25)
- Does resveratrol activate yeast Sir2 in vivo? (2007) (25)
- Genome-wide analysis of yeast aging. (2012) (24)
- The ongoing saga of sirtuins and aging. (2008) (24)
- End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging. (2013) (24)
- Rejuvenation: it's in our blood. (2014) (23)
- A genomic approach to yeast chronological aging. (2009) (23)
- The Biology of Aging (2016) (23)
- In vivo measurements reveal a single 5′-intron is sufficient to increase protein expression level in Caenorhabditis elegans (2019) (23)
- Loss of vacuolar acidity results in iron-sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae (2020) (22)
- PKC downregulation upon rapamycin treatment attenuates mitochondrial disease (2020) (21)
- An open science study of ageing in companion dogs (2022) (21)
- Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae (2016) (21)
- Geroscience in the Age of COVID-19 (2020) (21)
- Translational Geroscience: From invertebrate models to companion animal and human interventions. (2018) (20)
- Buffering the pH of the culture medium does not extend yeast replicative lifespan (2013) (20)
- Elevated MTORC1 signaling and impaired autophagy (2013) (20)
- A review of the biomedical innovations for healthy longevity (2017) (20)
- Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism (2021) (19)
- A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae (2017) (19)
- A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast (2020) (19)
- Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins (2019) (18)
- Hypertrophy and senescence factors in yeast aging. A reply to Bilinski et al. (2012) (18)
- An energetics perspective on geroscience: mitochondrial protonmotive force and aging (2021) (18)
- Genetic interaction with temperature is an important determinant of nematode longevity (2017) (18)
- Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron–sulfur protein (2015) (17)
- CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. (2017) (17)
- The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells. (2018) (17)
- Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency (2017) (17)
- Longevity and Aging in Budding Yeast (2006) (17)
- DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging (2019) (16)
- Human telomere biology : A contributory and interactive factor in aging , disease risks , and protection (2015) (16)
- Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes (2019) (16)
- A toolkit for DNA assembly, genome engineering and multicolor imaging for C. elegans. (2018) (16)
- Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans (2017) (15)
- Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States (2020) (15)
- Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity (2020) (15)
- Longevity genomics across species. (2007) (15)
- PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae (2015) (15)
- Latest advances in aging research and drug discovery (2019) (14)
- Single-gene deletions that restore mating competence to diploid yeast. (2008) (13)
- Defining molecular basis for longevity traits in natural yeast isolates (2015) (13)
- Canine Cognitive Dysfunction (CCD) scores correlate with amyloid beta 42 levels in dog brain tissue (2021) (13)
- Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans (2018) (12)
- The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast. (2020) (12)
- Saccharomyces cerevisiae SSD 1V Confers Longevity by a Sir 2 p-Independent Mechanism (2004) (12)
- Ageing: A healthy diet for stem cells (2012) (11)
- Aging-related research in the "-omics" age. (2004) (11)
- The MDT-15 Subunit of Mediator Interacts with Dietary Restriction to Modulate Longevity and Fluoranthene Toxicity in Caenorhabditis elegans (2011) (10)
- Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase (2014) (10)
- Molecular basis of ageing (2007) (10)
- Genome-wide approaches to understanding human ageing (2006) (10)
- Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast (2021) (9)
- Composition of Caenorhabditis elegans extracellular vesicles suggests roles in metabolism, immunity, and aging (2020) (9)
- Application of High-Throughput Technologies to Aging-Related Research (2006) (9)
- Electrophysiological measures of aging pharynx function in C. elegans reveal enhanced organ functionality in older, long-lived mutants. (2019) (8)
- Cell-to-cell variation in gene expression and the aging process (2021) (8)
- MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts. (2015) (8)
- DDS promotes longevity through a microbiome-mediated starvation signal. (2019) (8)
- A physicochemical roadmap of yeast replicative aging (2019) (8)
- Fertile Waters for Aging Research (2015) (8)
- New functional and biophysical insights into the mitochondrial Rieske iron-sulfur protein from genetic suppressor analysis in C. elegans (2016) (8)
- A new chronological survival assay in mammalian cell culture (2012) (8)
- The Role of TOR Signaling in Aging (2010) (8)
- Cell biology: A molecular age barrier (2008) (7)
- An inexpensive microscopy system for microfluidic studies in budding yeast (2019) (7)
- Time for a New Strategy in the War on Alzheimer’s Disease (2019) (7)
- Life Extension Pseudoscience and the SENS Plan (2006) (7)
- Correction: Why Is Aging Conserved and What Can We Do about it? (2015) (7)
- A prion accelerates proliferation at the expense of lifespan (2020) (6)
- RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial (2020) (6)
- It is Time to Embrace 21st-Century Medicine (2019) (6)
- Isolation and characterization of extracellular vesicles from Caenorhabditis elegans for multi-omic analysis (2018) (6)
- Searching for the elusive mitochondrial longevity signal in C. elegans (2014) (6)
- Research to Promote Longevity and Health Span in Companion Dogs: A Pediatric Perspective (2018) (6)
- Inter-organ regulation of haem homeostasis (2017) (5)
- Interpretable machine learning prediction of all-cause mortality (2021) (5)
- The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America. (2005) (5)
- Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin (2019) (5)
- Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project (2021) (4)
- Purification and Analysis of Caenorhabditis elegans Extracellular Vesicles. (2020) (4)
- A midlife longevity drug ? (2009) (4)
- Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of Saccharomyces cerevisiae (2019) (4)
- Meeting Report: Aging Research and Drug Discovery (2022) (4)
- Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan (2022) (4)
- A SYSTEMS-BIOLOGY APPROACH TO IDENTIFY CANDIDATE GENES FOR ALZHEIMER'S DISEASE BY INTEGRATING PROTEIN-PROTEIN INTERACTION NETWORK AND SUBSEQUENT IN VIVO VALIDATION OF CANDIDATE GENES USING A C. ELEGANS MODEL OF AB TOXICITY (2014) (4)
- Microarray Analysis of Gene Expression Changes in Aging (2005) (4)
- Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function (2022) (4)
- Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice (2022) (4)
- The NDUFS4 Knockout Mouse: A Dual Threat Model of Childhood Mitochondrial Disease and Normative Aging. (2021) (4)
- Evidence that C/EBP-β LAP Increases Fat Metabolism and Protects Against Diet-Induced Obesity in Response to mTOR Inhibition (2021) (4)
- Comparative Genetics of Aging (2011) (3)
- Evidence that conserved essential genes are enriched for pro-longevity factors (2022) (3)
- UV-Photoconversion of Ethosuximide from a Longevity-Promoting Compound to a Potent Toxin (2013) (3)
- Anti-ageing effects of protein restriction unpacked (2021) (3)
- Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging (2020) (3)
- Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast. (2019) (3)
- Oxygen and Aging (2014) (3)
- Targeting mTOR signaling to promote healthy longevity (2017) (3)
- The hypoxic response and aging (2009) (2)
- Iron status influences mitochondrial disease progression in Complex I-deficient mice (2021) (2)
- Amyloid beta-42 Levels in Companion Dog Brains Correlate with Age and Cognitive Function (2020) (2)
- Phenotypic and genotypic consequences of CRISPR/Cas9 editing of the replication origins in the rDNA of Saccharomyces cerevisiae (2019) (2)
- Translational control of methionine and serine metabolic pathways underpin the paralog-specific phenotypes of Rpl22 ribosomal protein mutants in cell division and replicative longevity (2020) (2)
- Replicative life span analysis in budding yeast. (2014) (2)
- The landscape of longevity across phylogeny (2020) (2)
- Differences in protein dosage underlie nongenetic differences in traits (2018) (2)
- Evolution of Natural Lifespan Variation and Molecular Strategies of Extended Lifespan (2020) (2)
- Chemical Warfare in the Battle of the Sexes (2014) (2)
- In vivo measurements reveal a single 5’ intron is sufficient to increase protein expression level in C. elegans (2018) (2)
- Cross species application of quantitative neuropathology assays developed for clinical Alzheimer’s disease samples (2019) (2)
- A probabilistic approach to using big data reveals Complex I as a potential Alzheimer's disease therapeutic target (2018) (1)
- Intermittent hypoxia therapy engages multiple longevity pathways to double lifespan in C.elegans (2022) (1)
- Capacity for oxidative phosphorylation does not decline with age in mitochondria from ndufs4 knockout mice (2013) (1)
- Evaluation of cognitive function in the Dog Aging Project: associations with baseline canine characteristics (2022) (1)
- Selected Abstracts from the American Aging Association 47th Annual Meeting “Improving Resilience to Delay Aging” Philadelphia, 2018 (2018) (1)
- Genomics and Genetics of Aging (2012) (1)
- Preservation of Mitochondrial Membrane Potential is Necessary for Lifespan Extension from Dietary Restriction (2022) (1)
- Author response: Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice (2016) (1)
- Deciphering the role of natural variation in age-related protein homeostasis (2013) (1)
- New insights into cell non-autonomous mechanisms of the C. elegans hypoxic response (2016) (1)
- Pharmacokinetics of long-term low-dose oral rapamycin in four healthy middle-aged companion dogs (2021) (1)
- Correction to: Pterocarpus marsupium extract extends replicative lifespan in budding yeast (2021) (1)
- Translational Geroscience: Targeting mTOR Signaling to Promote Healthy Longevity (2017) (1)
- Proceedings from the annual University of Washington Geroscience Symposium, October 23, 2020 (2021) (1)
- Deciphering the role of natural variation in age-related protein homeostasis (2013) (1)
- Pterocarpus marsupium extract extends replicative lifespan in budding yeast (2021) (1)
- Syringaresinol protects against hypoxia / reoxygenation-induced a FOXO 3-dependent mechanism (2014) (1)
- Faculty Opinions recommendation of The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. (2013) (1)
- Trinations aging symposium (2011) (1)
- Dynamics of age-related catastrophic mitotic failures and recovery in yeast (2018) (1)
- Generation and characterization of a tractable C. elegans model of tauopathy (2021) (1)
- High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity (2022) (1)
- COMBINING MACHINE LEARNING WITH AUTOMATED NEMATODE LIFESPAN ANALYSIS TO IDENTIFY MODIFIERS OF ALZHEIMER’S DISEASE (2019) (0)
- Multidimensional proteomics identifies molecular trajectories of cellular aging and rejuvenation (2023) (0)
- A computational framework identifying concordant gene expression-neuropathology associations reveals Complex I as a potential Alzheimer’s disease therapeutic target (2018) (0)
- PRESIDENTIAL SYMPOSIUM: EXPANDING THE GEROSCIENCE NETWORK (2019) (0)
- Geroscience approaches to obesity (2021) (0)
- A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs (2017) (0)
- Effects of high-dose rapamycin on health and metabolism in mice (2015) (0)
- Faculty Opinions recommendation of Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. (2013) (0)
- C. elegans Orthologs of Human Genes Differentially Expressed with Age are Enriched for Determinants of Longevity (2017) (0)
- The dog aging project: translational geroscience in companion animals (2016) (0)
- Decision letter: Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome (2019) (0)
- LEVERAGING THE NDUFS4-/- MOUSE AS A PLATFORM FOR TESTING LONGEVITY INTERVENTIONS (2022) (0)
- A robotic system for high-throughput automated lifespan and phenotyping analysis in C. elegans (2020) (0)
- Chapter 12 Genome-Wide Analysis of Yeast Aging (2011) (0)
- Rapamycin treatment attenuates age-associated periodontitis in mice (2017) (0)
- Faculty Opinions recommendation of Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction. (2013) (0)
- Optogenetic Increase in Mitochondrial Protonmotive Force Causes Increased Lifespan in C. elegans (2022) (0)
- Correction to: Pterocarpus marsupium extract extends replicative lifespan in budding yeast (2022) (0)
- Author response: A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast (2020) (0)
- Once-daily feeding associated with better outcomes 1 Title: Once-daily feeding is associated with better cognitive function and health in companion (2021) (0)
- Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency (2017) (0)
- Decision letter: Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta (2019) (0)
- An explainable AI framework for interpretable biological age (2022) (0)
- 1 Hot Topics Protein Translation , 2008 (2008) (0)
- Author response: Rapamycin rejuvenates oral health in aging mice (2020) (0)
- DECODER : A probabilistic approach to integrate big data reveals mitochondrial Complex I as a potential Alzheimer ’ s disease therapeutic target (2018) (0)
- Faculty Opinions recommendation of Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. (2011) (0)
- Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites and pathways that regulate lifespan (2023) (0)
- Faculty Opinions recommendation of Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. (2011) (0)
- Reasons for Exclusion of Apparently Healthy Mature Adult and Senior Dogs From a Clinical Trial (2021) (0)
- TIS11 AND CTH1 DEFICIENCY LEADS TO METABOLIC REPROGRAMING AND EXTENDS REPLICATIVE LIFESPAN IN YEAST (2018) (0)
- ESPO/ BIOLOGICAL SCIENCES SECTION SYMPOSIUM: EMERGING INSIGHTS IN INTERACTIONS AND NETWORKS IN THE BIOLOGY OF AGING DEVELOPING C. ELEGANS TO STUDY AGE-RELATED EXTRACELLULAR VESICLE SIGNALS (2019) (0)
- Author response: Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast (2021) (0)
- Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States (2020) (0)
- A ROBOTIC SYSTEM FOR HIGH-THROUGHPUT AUTOMATED LIFESPAN ANALYSIS IN C. ELEGANS (2019) (0)
- Correction: Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome (2014) (0)
- A SYSTEM TO IDENTIFY INHIBITORS OF MTOR SIGNALING USING HIGH-RESOLUTION GROWTH ANALYSIS IN S. CEREVISIAE (2019) (0)
- Conserved Links Between Nutrient Signaling, Translation and Aging (2009) (0)
- Faculty Opinions recommendation of Rapamycin slows aging in mice. (2013) (0)
- Pharmacological Interventions That Target Biological Aging (2020) (0)
- Decision letter: Quantitative mapping of human hair greying and reversal in relation to life stress (2021) (0)
- AGING AND MITOCHONDRIAL DISEASE: SHARED MECHANISMS AND THERAPIES? (2019) (0)
- Handbook of the Biology of Aging Ed. 8 (2015) (0)
- Decision letter: Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria (2019) (0)
- Lifespan Extension from Dietary Restriction is Mediated by Mitochondrial Membrane Potential in C. elegans (2022) (0)
- Oral health in geroscience: animal models and the aging oral cavity (2017) (0)
- How healthy is the healthspan concept? (2018) (0)
- hsp-16.2 chaperone biomarkers track physiological states of proteome dosage (2018) (0)
- LONGEVITY OVER THE COUNTER: INVESTIGATING THE EFFECTS OF COMMON DIETARY SUPPLEMENTS ON AGING (2019) (0)
- Companion dogs to test longevity interventions (2020) (0)
- Author response: Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity (2020) (0)
- FLAVIN-CONTAINING MONOOXYGENASES (FMOS): LONGEVITY-PROMOTING ENZYMES OR ATHEROSCLEROSIS RISK FACTOR? (2019) (0)
- Mitochondrial Protonmotive Force Regulates Aging and Longevity in C. elegans (2022) (0)
- In vivo measurements reveal a single 5′-intron is sufficient to increase protein expression level in Caenorhabditis elegans (2019) (0)
- divergent eukaryotic species Quantitative evidence for conserved longevity pathways between (2008) (0)
- Hot Topics Protein Translation, 2008 (2008) (0)
- Yeast Aging Proteome Unveiled a Novel Aging Regulation Pathway Mediated by the Chromatin Remodeling Complex ISW2 (2012) (0)
- University of Washington Nathan Shock Center: innovation to advance aging research (2021) (0)
- Aging, Genetics of (2013) (0)
- In grateful recognition of our Editorial Board (2016) (0)
- Author Correction: An open science study of ageing in companion dogs (2022) (0)
- Decision letter: Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes (2019) (0)
- Ramos Survival Mice , Rescues Cardiac and Skeletal Muscle Function , and Extends Deficient − Rapamycin Reverses Elevated mTORC 1 Signaling in Lamin A / C (2012) (0)
- DECODER: A probabilistic approach to integrate big data reveals mitochondrial Complex I as a potential therapeutic target for Alzheimer’s disease (2018) (0)
- Science Journals — AAAS (2020) (0)
- Biological Sciences Section Perspective (2020) (0)
- WormBot, an open-source robotics platform for survival and behavior analysis in C. elegans (2019) (0)
- Age-associated vulval integrity is an important marker of nematode healthspan (2016) (0)
- CLINICAL TRIALS IN GEROSCIENCE (2019) (0)
- Protein Kinase C Downregulation upon Rapamycin Treatment Attenuates Neuroinflammation and Mitochondrial Disease (2020) (0)
- Author response: DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging (2019) (0)
- A new era for research into aging (2021) (0)
- PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae (2015) (0)
- A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae (2017) (0)
- Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging (2017) (0)
- Author response: Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans (2018) (0)
- Geroscience approaches to obesity (2021) (0)
- The collaborative peer review framework as a model for training biomedical graduate students to perform rigorous, ethical peer review (2023) (0)
- Faculty Opinions recommendation of Regulation of Drosophila life span by olfaction and food-derived odors. (2013) (0)
- Author Correction: An open science study of ageing in companion dogs (2022) (0)
- Author's Reply (2006) (0)
- Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh Syndrome (2020) (0)
- Genetic analysis of longevity in Saccharomyces cerevisiae (2002) (0)
- The AGE Presents Introduction to Geroscience video lecture series (2021) (0)
- Leonard Guarente by two different mechanismsSaccharomyces cerevisiae alone promote longevity in SIR 2 complex and SIR 2 / 3 / 4 The (1999) (0)
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