Matthew Fuchter
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British chemist and academic
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Chemistry
Matthew Fuchter's Degrees
- PhD Chemistry University of Oxford
- Masters Chemistry University of Oxford
Why Is Matthew Fuchter Influential?
(Suggest an Edit or Addition)According to Wikipedia, Matthew John Fuchter is a British chemist who is a Professor of Chemistry at Imperial College London. His research focuses on the development and application of novel functional molecular systems to a broad range of areas; from materials to medicine. He has been awarded both the Harrison-Meldola Memorial Prize and the Corday–Morgan Prizes of the Royal Society of Chemistry. In 2020 he was a finalist for the Blavatnik Awards for Young Scientists.
Matthew Fuchter's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Circularly polarized light detection by a chiral organic semiconductor transistor (2013) (513)
- SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2 (2010) (384)
- The added value of small-molecule chirality in technological applications (2017) (283)
- Circularly Polarized Phosphorescent Electroluminescence with a High Dissymmetry Factor from PHOLEDs Based on a Platinahelicene. (2016) (261)
- Induction of Circularly Polarized Electroluminescence from an Achiral Light-Emitting Polymer via a Chiral Small-Molecule Dopant (2013) (258)
- Arylazopyrazoles: azoheteroarene photoswitches offering quantitative isomerization and long thermal half-lives. (2014) (208)
- Nonmetal catalyzed hydrogenation of carbonyl compounds. (2014) (173)
- Tuning Azoheteroarene Photoswitch Performance through Heteroaryl Design. (2017) (154)
- Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures (2014) (152)
- The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. (2009) (121)
- Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum (2012) (117)
- Emergent Properties of an Organic Semiconductor Driven by its Molecular Chirality. (2017) (97)
- Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases. (2013) (92)
- Designing effective 'frustrated Lewis pair' hydrogenation catalysts. (2017) (91)
- Metal-Free Hydrogenation Catalyzed by an Air-Stable Borane: Use of Solvent as a Frustrated Lewis Base** (2014) (89)
- Inverting the Handedness of Circularly Polarized Luminescence from Light-Emitting Polymers Using Film Thickness. (2019) (88)
- Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. (2012) (84)
- Facile Protocol for Water-Tolerant “Frustrated Lewis Pair”-Catalyzed Hydrogenation (2015) (82)
- A high throughput screen for next-generation leads targeting malaria parasite transmission (2018) (70)
- On the promise of photopharmacology using photoswitches: a medicinal chemist's perspective. (2020) (68)
- ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment (2018) (64)
- A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration. (2010) (64)
- N-heterocyclic carbene mediated activation of tetravalent silicon compounds: a critical evaluation. (2010) (63)
- Arylazopyrazoles for Long-Term Thermal Energy Storage and Optically-Triggered Heat Release below 0 °C. (2020) (61)
- The Discovery of a Highly Selective 5,6,7,8‐Tetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidin‐4(3H)‐one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model (2015) (56)
- Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells (2015) (56)
- Versatile Catalytic Hydrogenation Using A Simple Tin(IV) Lewis Acid (2016) (55)
- Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors. (2017) (52)
- 500‐Fold Amplification of Small Molecule Circularly Polarised Luminescence through Circularly Polarised FRET (2020) (52)
- Molecular Cancer Therapeutics SIRT Inhibitors Induce Cell Death and p 53 Acetylation through Targeting Both SIRT 1 and SIRT 2 (2010) (51)
- [7]-Helicene: a chiral molecular tweezer for silver(I) salts. (2012) (51)
- Porphyrazines: Designer Macrocycles by Peripheral Substituent Change (2008) (50)
- A scalable and expedient route to 1-aza[6]helicene derivatives and its subsequent application to a chiral-relay asymmetric strategy. (2013) (49)
- Perspectives on natural product epigenetic modulators in chemical biology and medicine. (2013) (47)
- On the histone lysine methyltransferase activity of fungal metabolite chaetocin. (2013) (46)
- Ring-opening metathesis polymer sphere-supported seco-porphyrazines: efficient and recyclable photooxygenation catalysts. (2006) (45)
- On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. (2011) (41)
- Synthesis of porphyrazine-octaamine, hexamine and diamine derivatives (2005) (41)
- Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket (2017) (39)
- Current limitations and future opportunities for epigenetic therapies. (2012) (39)
- Histone Methyltransferase Inhibitors Are Orally Bioavailable, Fast-Acting Molecules with Activity against Different Species Causing Malaria in Humans (2014) (39)
- Natural optical activity as the origin of the large chiroptical properties in π-conjugated polymer thin films (2020) (39)
- UV‐Sensitive Wearable Devices for Colorimetric Monitoring of UV Exposure (2020) (35)
- On the determination of the stereochemistry of semisynthetic natural product analogues using chiroptical spectroscopy: desulfurization of epidithiodioxopiperazine fungal metabolites. (2011) (34)
- Photoswitchable basicity through the use of azoheteroarenes. (2016) (32)
- An unusual oxidative rearrangement of [7]-helicene (2012) (32)
- A computational exploration of the crystal energy and charge-carrier mobility landscapes of the chiral [6]helicene molecule. (2018) (31)
- Clean and efficient synthesis of O-silylcarbamates and ureas in supercritical carbon dioxide. (2008) (31)
- Highly efficient inverted circularly polarized organic light emitting diodes. (2020) (31)
- A combinatorial approach to improving the performance of azoarene photoswitches (2019) (31)
- Direct Reductive Amination of Carbonyl Compounds Catalyzed by a Moisture Tolerant Tin(IV) Lewis Acid (2018) (29)
- Lanthanide replacement in organic synthesis: Luche-type reduction of α,β-unsaturated ketones in the presence of calcium triflate (2012) (28)
- Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites (2016) (28)
- Chemical Z − E Isomer Switching of Arylazopyrazoles Using Acid (2019) (27)
- New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation. (2011) (25)
- Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a (2014) (25)
- Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood‐Stage Antimalarial Compounds (2014) (25)
- The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors. (2012) (24)
- Inhibitor Selectivity for Cyclin‐Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study (2017) (24)
- Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors (2013) (24)
- Porphyrazines as molecular scaffolds: flexible syntheses of novel multimetallic complexes. (2006) (23)
- Intense redox-driven chiroptical switching with a 580 mV hysteresis actuated through reversible dimerization of an azoniahelicene. (2017) (22)
- The antimalarial screening landscape—looking beyond the asexual blood stage (2019) (21)
- Pathways to increase the dissymmetry in the interaction of chiral light and chiral molecules† (2021) (21)
- Diaryl ether synthesis in supercritical carbon dioxide in batch and continuous flow modes. (2008) (18)
- Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity (2017) (18)
- The design and synthesis of novel IBiox N-heterocyclic carbene ligands derived from substituted amino-indanols. (2012) (18)
- Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance (2013) (18)
- Fullerene Desymmetrization as a Means to Achieve Single‐Enantiomer Electron Acceptors with Maximized Chiroptical Responsiveness (2020) (17)
- Mechanistic and Chiroptical Studies on the Desulfurization of Epidithiodioxopiperazines Reveal Universal Retention of Configuration at the Bridgehead Carbon Atoms (2013) (16)
- Highly Ligand Efficient and Selective N‐2‐(Thioethyl)picolinamide Histone Deacetylase Inhibitors Inspired by the Natural Product Psammaplin A (2013) (16)
- High Responsivity Circular Polarized Light Detectors based on Quasi Two-Dimensional Chiral Perovskite Films (2022) (16)
- Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum. (2018) (16)
- Efficient Electrocatalytic Switching of Azoheteroarenes in the Condensed Phases. (2021) (15)
- Tricyclic-isoxazolidine analogues via intramolecular 1,3-dipolar cycloaddition reactions of nitrones (2010) (14)
- ROM polymerization-capture-release strategy for the chromatography-free synthesis of novel unsymmetrical porphyrazines. (2005) (14)
- One-pot formation of allylic chlorides from carbonyl derivatives. (2008) (12)
- Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors. (2014) (12)
- ROM polymerization-capture-release: application to the synthesis of unsymmetrical porphyrazinedithiols and peripherally metalated derivatives. (2005) (11)
- Multigram synthesis of a water-soluble porphyrazine and derived seco-porphyrazine labeling agents. (2007) (11)
- Enantioselective reduction of N-alkyl ketimines with frustrated Lewis pair catalysis using chiral borenium ions. (2019) (10)
- Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)** (2021) (10)
- The transcriptional repressor REV-ERB as a novel target for disease. (2020) (10)
- Calcium-mediated stereoselective reduction of α,β-epoxy ketones (2014) (10)
- A ‘push–pull’ tropylium-fused aminoporphyrazine (2009) (9)
- Highly Selective High‐Speed Circularly Polarized Photodiodes Based on π‐Conjugated Polymers (2021) (9)
- Dual G9A/EZH2 Inhibition Stimulates Antitumor Immune Response in Ovarian High-Grade Serous Carcinoma (2022) (9)
- Regiochemical observations on the lithiation of 1,2,4-trichlorobenzene and reaction with DMF and oxamide electrophiles in THF (2003) (8)
- Strongly Circularly Polarized Crystalline and β‐Phase Emission from Poly(9,9‐dioctylfluorene)‐Based Deep‐Blue Light‐Emitting Diodes (2021) (8)
- The influence of nitrogen position on charge carrier mobility in enantiopure aza[6]helicene crystals. (2018) (8)
- Chiroptical studies on brevianamide B: vibrational and electronic circular dichroism confronted. (2015) (7)
- Structure-activity relationship studies of a novel class of transmission blocking antimalarials targeting male gametes. (2019) (7)
- Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides. (2018) (7)
- Effective macrophage delivery using RAFT copolymer derived nanoparticles (2018) (7)
- Direct NHC-catalysed redox amidation using CO2 for traceless masking of amine nucleophiles. (2016) (6)
- Gold(I) mediated rearrangement of [7]-helicene to give a benzo[cd]pyrenium cation embedded in a chiral framework. (2014) (6)
- Computational Screening of Chiral Organic Semiconductors: Exploring Side-Group Functionalization and Assembly to Optimize Charge Transport (2021) (6)
- TRPswitch - a step function chemo-optogenetic ligand for the vertebrate TRPA1 channel. (2020) (6)
- Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes (2014) (5)
- Stoichiometric C-H arylation of tricarbonyl(arene)chromium complexes bearing pyridine directing groups. (2013) (5)
- Synthesis of sterically encumbered C10-arylated benzo[h]quinolines using ortho-substituted aryl boronic acids. (2013) (5)
- The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957 (2021) (5)
- Plasmodium falciparum protein Pfs16 is a target for transmission-blocking antimalarial drug development (2021) (4)
- Design, synthesis and initial characterisation of a radiolabelled [(18)F]pyrimidoindolone probe for detecting activated caspase-3/7. (2015) (4)
- Dual EZH 2 and EHMT 2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells (4)
- Tuning Halide Composition Allows Low Dark Current Perovskite Photodetectors With High Specific Detectivity (2022) (4)
- Computational Screening of Organic Semiconductors: Exploring Side-Group Functionalisation and Assembly to Optimise Charge Transport in Chiral Molecules (2020) (3)
- 230MO First in human, modular study of samuraciclib (CT7001), a first-in-class, oral, selective inhibitor of CDK7, in patients with advanced solid malignancies (2021) (3)
- Photocontrolled Energy Storage in Azobispyrazoles with Exceptionally Large Light Penetration Depths (2022) (3)
- A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein (2023) (3)
- Correction: A computational exploration of the crystal energy and charge-carrier mobility landscapes of the chiral [6]helicene molecule. (2018) (3)
- ortho-Substituted 1,8-Diarylnaphthalenes: Conformational Thermodynamics and Kinetics (2013) (3)
- Corrigendum: Inhibitor Selectivity for Cyclin‐Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study (2018) (3)
- Anomalous circularly polarized light emission in organic light-emitting diodes caused by orbital–momentum locking (2022) (2)
- Correction to "Arylazopyrazoles: Azoheteroarene Photoswitches Offering Quantitative Isomerization and Long Thermal Half-Lives. (2016) (2)
- Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles (2022) (2)
- Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs) (2022) (2)
- Anomalous circularly polarized light emission caused by the chirality-driven topological electronic properties (2022) (2)
- On the factors influencing the chiroptical response of conjugated polymer thin films. (2021) (2)
- Metal-Free Hydrogenation Catalyzed by an Air-Stable Borane: Use of Solvent as a Frustrated Lewis Base. (2015) (1)
- 554 Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells (2014) (1)
- Best practices in the measurement of circularly polarised photodetectors (2022) (1)
- Controlling anisotropic properties by manipulating the orientation of chiral small molecules. (2022) (1)
- A high throughput screen for next-generation leads targeting malaria parasite transmission (2018) (1)
- A Unified Model to Explain the Large Chiroptical Effects in Polymer Systems Through Natural Optical Activity (2020) (1)
- Serendipitous synthesis of trimetallic porphyrazine triads (2009) (1)
- Ring‐Opening Metathesis Polymer Sphere Supported seco‐Porphyrazines: Efficient and Recyclable Photooxygenation Catalysts. (2006) (1)
- Enantiomerically Pure Fullerenes as a Means to Enhance the Performance of Perovskite Solar Cells (2023) (1)
- Abstract B166: Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. (2011) (0)
- Enhancing hole carrier injection via low electrochemical doping on circularly polarized polymer light-emitting diodes (2022) (0)
- [5]-Helistatins: Tubulin-Binding Helicenes with Antimitotic Activity (2022) (0)
- Harnessing the power of cryo-EM for development of cancer therapeutics: high-resolution structures of the human CDK-activating kinase bound to inhibitors (2022) (0)
- optical as the origin of the large chiroptical properties in π-conjugated polymer thin films. (2020) (0)
- Abstract B165: Structural and biological studies on analogues of the natural product histone methyltransferase inhibitor chaetocin. (2011) (0)
- Photooxygenation Using ROM Polymer Sphere-Supported seco-Porphyrazines (2006) (0)
- Abstract PL05-04: Epigenetic marks as biomarkers and their mechanisms of maintenance as targets in ovarian cancer. (2011) (0)
- Abstract 2066: Modulation of homologous recombination repair pathway gene expression by a dual EZH2 and EHMT2 histone methyltransferase inhibitor and synergy with PARP inhibitors in ovarian cancer (2021) (0)
- Simmons—Smith Cyclopropanation (2011) (0)
- Tricyclic-Isoxazolidine Analogues via Intramolecular 1,3-Dipolar Cycloaddition Reactions of Nitrones. (2010) (0)
- The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer (2022) (0)
- Emerging properties from mechanical tethering within a post-synthetically functionalised catenane scaffold (2022) (0)
- Abstract 694: Development of selective and potent CDK7 inhibitors for breast cancer therapy. (2013) (0)
- MASC 2022: What challenges and opportunities do supramolecular chemists face in coming years? (2022) (0)
- Cope Elimination Reaction (2008) (0)
- Abstract 700: Gene expression profiling of cyclin-dependent kinase (CDK) inhibition in cancer cells. (2013) (0)
- Abstract P1-10-05: ICEC0942, a new oral selective inhibitor of the cell cycle and transcriptional regulator CDK7 for the treatment of estrogen receptor positive and negative breast cancer (2018) (0)
- Dual G9A and EZH2 inhibition stimulates an anti-tumour immune response in ovarian high-grade serous carcinoma (2021) (0)
- Abstract A162: Targeting chromatin: Small molecules reactivating H3K27me3 silenced genes. (2011) (0)
- Chiral Materials: Fullerene Desymmetrization as a Means to Achieve Single‐Enantiomer Electron Acceptors with Maximized Chiroptical Responsiveness (Adv. Mater. 1/2021) (2021) (0)
- Mid-infrared Chemical Nano-imaging for Intra-cellular Drug Localisation (2018) (0)
- Paper No 2.2: Circularly Polarised Organic Light‐Emitting Diodes Using Conventional Light‐Emitting Polymers and a Chiral Small‐Molecule Dopant (2013) (0)
- Inhibitor That Shows Antitumor Activity The Development of a Selective Cyclin-Dependent Kinase (2009) (0)
- Highly Selective Ultrafast Circularly Polarized Photodiodes Based on π-Conjugated Polymers (2021) (0)
- Abstract P1-18-10: A clinical study of samuraciclib (CT7001), a first-in-class, oral, selective inhibitor of CDK7, in patients with advanced triple negative breast cancer (TNBC) (2022) (0)
- Inside front cover. (2017) (0)
- Inhibiting Ehmt2 and Ezh2 histone methyltransferases alters the immune microenvironment in a Trp53-/- murine ovarian cancer model (2019) (0)
- Lanthanide Replacement in Organic Synthesis: Luche‐Type Reduction of α,β‐Unsaturated Ketones in the Presence of Calcium Triflate. (2012) (0)
- Materials for chiral light control (2023) (0)
- In memoriam Alasdair James Campbell (11 May 1961–27 February 2021) (2021) (0)
- Catalytic activity of HDAC8 and HDAC11 (2010) (0)
- Correction: Best practices in the measurement of circularly polarised photodetectors (2022) (0)
- Calcium-Mediated Stereoselective Reduction of α,β-Epoxy Ketones. (2015) (0)
- Correction to Inverting the Handedness of Circularly Polarized Luminescence from Light-Emitting Polymers Using Film Thickness. (2022) (0)
- Synergy in reversing platinum resistance by combined inhibition of EZH2 and EHMT1/2 (2016) (0)
- Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells (2023) (0)
- Corrigendum (2008) (0)
- An S-Shaped Double Helicene Showing both Multi-Resonance Thermally Activated Delayed Fluorescence and Circularly Polarized Luminescence (2021) (0)
- Chiral light detection via a chiral organic semiconductor transistor (2014) (0)
- Glycosylated Nanoparticles Derived from RAFT Polymerization for Effective Drug Delivery to Macrophages. (2020) (0)
- Strong induced chiroptical effects in light emitting polymer blends (Conference Presentation) (2018) (0)
- Synthetic studies on the reverse antibiotic natural products, the nybomycins. (2019) (0)
- Computed conformations of cis-dinaphthylethene 1 (2015) (0)
- Engineering the sign of circularly polarized emission in achiral polymer – chiral small molecule blends as a function of blend ratio (2022) (0)
- Label-Free Chemical Nano-Imaging of Intracellular Drug Binding Sites (2020) (0)
- Correction to "Highly Efficient Inverted Circularly Polarized Organic Light Emitting Diodes". (2022) (0)
- PROFILE: Early Excellence in Physical Organic Chemistry (2014) (0)
- Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells (2015) (0)
- Correction to Emergent Properties of an Organic Semiconductor Driven by its Molecular Chirality. (2018) (0)
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