Matthias G. Von Herrath
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(Suggest an Edit or Addition)Matthias G. Von Herrath's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Type 1 diabetes: etiology, immunology, and therapeutic strategies. (2011) (971)
- Resolution of a chronic viral infection after interleukin-10 receptor blockade (2006) (574)
- Molecular Mimicry, Bystander Activation, or Viral Persistence: Infections and Autoimmune Disease (2006) (566)
- Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients (2012) (551)
- Antigen-driven effector CD8 T cell function regulated by T-bet (2003) (447)
- How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. (1994) (340)
- CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge (1996) (325)
- Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. (2006) (317)
- Viral Trigger for Type 1 Diabetes (2008) (268)
- Faculty Opinions recommendation of Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. (2020) (262)
- Rho Family Proteins Modulate Rapid Apoptosis Induced by Cytotoxic T Lymphocytes and Fas* (2000) (251)
- Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. (2004) (229)
- Naive Precursor Frequencies and MHC Binding Rather Than the Degree of Epitope Diversity Shape CD8+ T Cell Immunodominance1 (2008) (219)
- Interferon-γ Is Essential for Destruction of β Cells and Development of Insulin-dependent Diabetes Mellitus (1997) (219)
- Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. (1999) (210)
- Impaired immunoproteasome assembly and immune responses in PA28-/- mice. (1999) (191)
- Among CXCR3 Chemokines, IFN-γ-Inducible Protein of 10 kDa (CXC Chemokine Ligand (CXCL) 10) but Not Monokine Induced by IFN-γ (CXCL9) Imprints a Pattern for the Subsequent Development of Autoimmune Disease 1 (2003) (190)
- Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes. (1995) (185)
- Evidence for an Underlying CD4 Helper and CD8 T-Cell Defect in B-Cell-Deficient Mice: Failure To Clear Persistent Virus Infection after Adoptive Immunotherapy with Virus-Specific Memory Cells from μMT/μMT Mice (1998) (183)
- Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes (2016) (182)
- Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes (2014) (180)
- Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. (2002) (178)
- CD8αα-Mediated Survival and Differentiation of CD8 Memory T Cell Precursors (2004) (178)
- CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells. (2002) (175)
- How Does Type 1 Diabetes Develop? (2011) (167)
- Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice. (1996) (165)
- Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice (2009) (164)
- A Dual Role for TNF-α in Type 1 Diabetes: Islet-Specific Expression Abrogates the Ongoing Autoimmune Process When Induced Late but Not Early During Pathogenesis1 (2001) (161)
- Infections and Autoimmunity—Good or Bad?1 (2005) (149)
- Translational Mini‐Review Series on Type 1 Diabetes: Immune‐based therapeutic approaches for type 1 diabetes (2007) (146)
- Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. (2009) (136)
- CD4 T cell differentiation in type 1 diabetes (2016) (135)
- Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes. (2000) (131)
- DNA immunization to prevent autoimmune diabetes. (1999) (130)
- Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient. (2004) (125)
- α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes (2018) (123)
- Virus infections in type 1 diabetes. (2012) (121)
- NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner. (2009) (114)
- Current Concepts on the Pathogenesis of Type 1 Diabetes—Considerations for Attempts to Prevent and Reverse the Disease (2015) (114)
- A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes. (2004) (114)
- Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN–JDRF Type 1 Diabetes Combination Therapy Assessment Group (2010) (112)
- Plasmid Vaccination with Insulin B Chain Prevents Autoimmune Diabetes in Nonobese Diabetic Mice1 (2001) (111)
- Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes (2013) (110)
- T-bet Controls Autoaggressive CD8 Lymphocyte Responses in Type 1 Diabetes (2004) (109)
- Islet-Specific Expression of CXCL10 Causes Spontaneous Islet Infiltration and Accelerates Diabetes Development1 (2005) (108)
- Antigen-Specific Immunotherapy for Type 1 Diabetes: Maximizing the Potential (2010) (106)
- The urgent need for integrated science to fight COVID-19 pandemic and beyond (2020) (106)
- Induction, acceleration or prevention of autoimmunity by molecular mimicry. (2004) (101)
- Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus (1994) (97)
- Viral infection prevents diabetes by inducing regulatory T cells through NKT cell–plasmacytoid dendritic cell interplay (2011) (94)
- Insulin in oral immune "tolerance": a one-amino acid change in the B chain makes the difference. (1999) (88)
- How viral infections affect the autoimmune process leading to type 1 diabetes. (2005) (86)
- Initiation of autoimmunity. (2004) (86)
- CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. (2004) (86)
- Mouse Models for Type 1 Diabetes. (2009) (84)
- Intravital imaging of CTLs killing islet cells in diabetic mice. (2012) (84)
- Viral triggers for autoimmunity: is the 'glass of molecular mimicry' half full or half empty? (2010) (80)
- Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset (2017) (80)
- An essential role for type 1 interferon-gamma in terminating persistent viral infection. (1995) (78)
- Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes. (1997) (77)
- CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes. (2014) (74)
- Pathological changes in the islet milieu precede infiltration of islets and destruction of beta-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM. (1997) (72)
- Murine Antithymocyte Globulin Therapy Alters Disease Progression in NOD Mice by a Time-Dependent Induction of Immunoregulation (2008) (72)
- Lost in translation (2005) (70)
- IP-10 and Type 1 Diabetes: A Question of Time and Location (2004) (69)
- CTL escape viral variants. II. Biologic activity in vivo. (1995) (68)
- CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients (2014) (67)
- Immunotherapy for the Prevention and Treatment of Type 1 Diabetes (2009) (66)
- Simian immunodeficiency virus (SIV)-specific CTL in cerebrospinal fluid and brains of SIV-infected rhesus macaques. (1995) (65)
- OX40 Facilitates Control of a Persistent Virus Infection (2012) (65)
- Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma (2012) (64)
- Moving towards efficient therapies in type 1 diabetes: to combine or not to combine? (2007) (64)
- Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. (1999) (63)
- Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets. (2012) (61)
- Lack of Intrinsic CTLA-4 Expression Has Minimal Effect on Regulation of Antiviral T-Cell Immunity (2006) (60)
- Nonmitogenic CD3 Antibody Reverses Virally Induced (Rat Insulin Promoter-Lymphocytic Choriomeningitis Virus) Autoimmune Diabetes Without Impeding Viral Clearance1 (2002) (60)
- The viral paradigm in type 1 diabetes: Who are the main suspects? (2016) (59)
- Role of viruses in type I diabetes. (1998) (59)
- Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes. (2008) (59)
- Histopathology of type 1 diabetes: old paradigms and new insights. (2009) (58)
- A Novel Technique for the In Vivo Imaging of Autoimmune Diabetes Development in the Pancreas by Two-Photon Microscopy (2010) (56)
- Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase (2015) (54)
- Sensitization to self (virus) antigen by in situ expression of murine interferon-gamma. (1995) (53)
- Virus-Induced Diabetes in a Transgenic Model: Role of Cross-Reacting Viruses and Quantitation of Effector T Cells Needed To Cause Disease (2000) (53)
- Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response. (1995) (53)
- Infection as a cause of type 1 diabetes? (2012) (52)
- Transforming Growth Factor-β Suppresses the Activation of CD8+ T-Cells When Naïve but Promotes Their Survival and Function Once Antigen Experienced (2008) (52)
- Potential viral pathogenic mechanism in human type 1 diabetes (2014) (48)
- Trials in type 1 diabetes: Antigen-specific therapies. (2013) (47)
- Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial. (2021) (46)
- Coupling of oral human or porcine insulin to the B subunit of cholera toxin (CTB) overcomes critical antigenic differences for prevention of type I diabetes (2003) (46)
- Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses. (2000) (46)
- Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ (2010) (45)
- Molecular and cellular control of T1/T2 immunity at the interface between antimicrobial defense and immune pathology. (2004) (45)
- Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo. (2005) (45)
- In vivo treatment with a MHC class I-restricted blocking peptide can prevent virus-induced autoimmune diabetes. (1998) (45)
- The Role of Innate Immunity in Autoimmunity (2004) (44)
- Preferential Escape of Subdominant CD8+ T Cells During Negative Selection Results in an Altered Antiviral T Cell Hierarchy 1 (2003) (44)
- Protection against or triggering of Type 1 diabetes? Different roles for viral infections (2011) (43)
- TLR2 signaling improves immunoregulation to prevent type 1 diabetes (2011) (42)
- Pancreatic Tissue Transplanted in TheraCyte™ Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes (2016) (42)
- Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes. (2010) (42)
- Preexisting Autoantibodies Predict Efficacy of Oral Insulin to Cure Autoimmune Diabetes in Combination With Anti-CD3 (2012) (42)
- Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice (1993) (41)
- Essential Role for TLR9 in Prime but Not Prime-Boost Plasmid DNA Vaccination To Activate Dendritic Cells and Protect from Lethal Viral Infection (2010) (39)
- About CD4pos CD25pos regulatory cells. (2002) (36)
- Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process? (2017) (36)
- Current and future therapies for type 1 diabetes (2021) (36)
- The Cholera Toxin B Subunit is a Mucosal Adjuvant for Oral Tolerance Induction in Type 1 Diabetes (2003) (35)
- SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes. (2006) (35)
- Remodeling rodent models to mimic human type 1 diabetes (2009) (35)
- Suppression of diabetes by accumulation of non–islet-specific CD8+ effector T cells in pancreatic islets (2018) (35)
- Exogenous OX40 Stimulation during Lymphocytic Choriomeningitis Virus Infection Impairs Follicular Th Cell Differentiation and Diverts CD4 T Cells into the Effector Lineage by Upregulating Blimp-1 (2013) (35)
- Novel strategies to eliminate persistent viral infections. (2008) (34)
- The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes (2020) (33)
- Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop. (2001) (33)
- Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice (2013) (33)
- The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes. (2013) (32)
- Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment. (2011) (32)
- Different Diabetogenic Potential of Autoaggressive CD8+ Clones Associated with IFN-γ-Inducible Protein 10 (CXC Chemokine Ligand 10) Production but Not Cytokine Expression, Cytolytic Activity, or Homing Characteristics1 (2005) (31)
- Regulatory Immune Mechanisms beyond Regulatory T Cells. (2019) (31)
- Enterovirus Infection and Type 1 Diabetes: Closing in on a Link? (2015) (30)
- A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice (2015) (30)
- Variable effects of transgenic c-Maf on autoimmune diabetes. (2001) (30)
- Recent advances in understanding Type 1 Diabetes (2016) (29)
- Structural and Functional Identification of Major Histocompatibility Complex Class I-restricted Self-peptides as Naturally Occurring Molecular Mimics of Viral Antigens (2001) (29)
- Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis. (2011) (29)
- Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes (2018) (29)
- Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes (2016) (29)
- Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes. (2017) (28)
- Reduction of Antiviral CD8 Lymphocytes In Vivo with Dendritic Cells Expressing Fas Ligand—Increased Survival of Viral (Lymphocytic Choriomeningitis Virus) Central Nervous System Infection1 (2002) (28)
- Infection-Triggered Regulatory Mechanisms Override the Role of STAT 4 in Control of the Immune Response to Influenza Virus Antigens (2003) (28)
- TGF-β blockade does not improve control of an established persistent viral infection. (2012) (28)
- Exacerbated Pathology of Viral Encephalitis in Mice with Central Nervous System-Specific Autoantibodies (2007) (28)
- Functional Redundancy of CXCR3/CXCL10 Signaling in the Recruitment of Diabetogenic Cytotoxic T Lymphocytes to Pancreatic Islets in a Virally Induced Autoimmune Diabetes Model (2013) (27)
- The microbiology of human hygiene and its impact on type 1 diabetes (2012) (27)
- Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals (2011) (26)
- 2011 Update: antigen-specific therapy in type 1 diabetes (2011) (26)
- Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment. (2010) (26)
- Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications (2018) (26)
- Virtual Optimization of Nasal Insulin Therapy Predicts Immunization Frequency to Be Crucial for Diabetes Protection (2010) (25)
- NKG2D blockade facilitates diabetes prevention by antigen-specific Tregs in a virus-induced model of diabetes. (2013) (25)
- How viral infections enhance or prevent type 1 diabetes‐from mouse to man (2011) (25)
- Alpha cells, the main source of IL-1β in human pancreas. (2017) (25)
- A Deeper Look into Type 1 Diabetes – Imaging Immune Responses during Onset of Disease (2016) (24)
- Transforming growth factor-beta fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice. (1996) (24)
- Immunotherapy of type 1 diabetes--how to rationally prioritize combination therapies in T1D. (2010) (23)
- Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes. (2019) (23)
- Role of viruses in the loss of tolerance to self-antigens and in autoimmune diseases. (1995) (23)
- Increased Memory Conversion of Naïve CD8 T Cells Activated during Late Phases of Acute Virus Infection Due to Decreased Cumulative Antigen Exposure (2011) (22)
- Pathogenesis and treatment of virus-induced autoimmune diabetes: novel insights gained from the RIP-LCMV transgenic mouse model. (1997) (22)
- Factors impeding the discovery of an intervention‐based treatment for type 1 diabetes (2016) (22)
- Use of a high-affinity peptide that aborts MHC-restricted cytotoxic T lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo. (1999) (22)
- Non-antigenic and antigenic interventions in type 1 diabetes (2013) (21)
- No Significant CTL Cross-Priming by Dendritic Cell-Derived Exosomes during Murine Lymphocytic Choriomeningitis Virus Infection1 (2009) (21)
- Inflammation and Hyperglycemia Mediate Deaf1 Splicing in the Pancreatic Lymph Nodes via Distinct Pathways During Type 1 Diabetes (2014) (21)
- Low-affinity cytotoxic T-lymphocytes require IFN-gamma to clear an acute viral infection. (1997) (20)
- Minimal Impact of a De Novo–Expressed β-Cell Autoantigen on Spontaneous Diabetes Development in NOD Mice (2007) (19)
- IP-10 and type 1 diabetes: a question of time and location. (2004) (19)
- Immunohistochemical assessment of glucagon‐like peptide 1 receptor (GLP‐1R) expression in the pancreas of patients with type 2 diabetes (2017) (19)
- Rational development of antigen-specific therapies for type 1 diabetes. (2007) (18)
- Combination Therapy With an Anti–IL-1β Antibody and GAD65 DNA Vaccine Can Reverse Recent-Onset Diabetes in the RIP-GP Mouse Model (2014) (18)
- Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis (2019) (18)
- Islet regeneration needed for overcoming autoimmune destruction – considerations on the pathogenesis of type 1 diabetes (2004) (18)
- Obstacles to identifying viruses that cause autoimmune disease. (2000) (18)
- Regulatory T cells control diabetes without compromising acute anti-viral defense. (2014) (18)
- Thymic Tolerance to Only One Viral Protein Reduces Lymphocytic Choriomeningitis Virus-Induced Immunopathology and Increases Survival in Perforin-Deficient Mice (1999) (18)
- Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of beta cell mass. (2008) (17)
- Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse. (2016) (17)
- IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes. (2019) (17)
- Immune responsiveness, tolerance and dsRNA: implications for traditional paradigms. (2003) (17)
- Following the Fate of One Insulin-Reactive CD4 T cell (2012) (17)
- Regulatory T‐cells in type 1 diabetes (2004) (16)
- Introducing baselines for therapeutic use of regulatory T cells and cytokines in autoimmunity. (2003) (15)
- Regulatory T cells and type 1 diabetes. (2004) (15)
- CD103 is dispensable for anti-viral immunity and autoimmunity in a mouse model of virally-induced autoimmune diabetes. (2009) (15)
- Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis. (1996) (15)
- Immunosuppressive Mechanisms During Viral Infectious Diseases (2010) (15)
- Protection from type 1 diabetes in the face of high levels of activated autoaggressive lymphocytes in a viral transgenic mouse model crossed to the SV129 strain. (2001) (15)
- Tolerance induction with agonist peptides recognized by autoaggressive lymphocytes is transient: therapeutic potential for type 1 diabetes is limited and depends on time-point of administration, choice of epitope and adjuvant. (2001) (14)
- Comparison of human brain and liver glutamate dehydrogenase cDNAS. (1987) (14)
- Transgenic Animal Models for Type 1 Diabetes: Linking a Tetracycline-Inducible Promoter with a Virus-Inducible Mouse Model (2002) (13)
- Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice (2020) (13)
- Type 1 diabetes vaccine development: Animal models vs. humans (2011) (13)
- Expression level of a pancreatic neo-antigen in beta cells determines degree of diabetes pathogenesis. (2010) (13)
- Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells. (2004) (13)
- Combination therapies for type 1 diabetes: why not now? (2010) (13)
- Cure of Chronic Viral Infection and Virus-Induced Type 1 Diabetes by Neutralizing Antibodies (2006) (12)
- Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes. (2014) (12)
- Humanizing Animal Models: A Key to Autoimmune Diabetes Treatment (2011) (12)
- One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent-Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24 (2021) (12)
- Bystander suppression induced by oral tolerance. (1997) (12)
- Development of Autoimmune Diabetes in the Absence of Detectable IL-17A in a CD8-Driven Virally Induced Model (2011) (12)
- The Development of Immunotherapy Strategies for the Treatment of Type 1 Diabetes (2018) (12)
- Immunotherapies and immune biomarkers in Type 1 diabetes: A partnership for success. (2015) (12)
- How can we improve the translational landscape for a faster cure of type 1 diabetes? (2009) (11)
- Anti‐thymoglobulin (ATG) treatment does not reverse type 1 diabetes in the acute virally induced rat insulin promoter‐lymphocytic choriomeningitis virus (RIP‐LCMV) model (2011) (11)
- Regulation of virally induced autoimmunity and immunopathology: contribution of LCMV transgenic models to understanding autoimmune insulin-dependent diabetes mellitus. (2002) (11)
- New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes (2021) (11)
- Is activation of autoreactive lymphocytes always detrimental? Viral infections and regulatory circuits in autoimmunity. (2001) (10)
- Incidental CD8 T cell reactivity against caspase‐cleaved apoptotic self‐antigens from ubiquitously expressed proteins in islets from prediabetic human leucocyte antigen‐A2 transgenic non‐obese diabetic mice (2011) (10)
- Emerging immune therapies in type 1 diabetes and pancreatic islet transplantation (2013) (10)
- Direct Infection of Dendritic Cells during Chronic Viral Infection Suppresses Antiviral T Cell Proliferation and Induces IL-10 Expression in CD4 T Cells (2014) (10)
- E1-INT (Transition Therapeutics/Novo Nordisk). (2005) (10)
- The Hsp60 peptide p277 enhances anti-CD3 mediated diabetes remission in non-obese diabetic mice. (2015) (10)
- Cure of chronic viral infection by neutralizing antibody treatment. (2007) (9)
- Islet beta-cell death - fuel to sustain autoimmunity? (2007) (9)
- Interleukin 6 in diabetes, chronic kidney disease, and cardiovascular disease: mechanisms and therapeutic perspectives (2022) (9)
- Can We Learn From Viruses How to Prevent Type 1 Diabetes? (2009) (9)
- Blockade but Not Overexpression of the Junctional Adhesion Molecule C Influences Virus-Induced Type 1 Diabetes in Mice (2013) (9)
- Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in β cells prevent autoimmune diabetes (2009) (9)
- HLA class I hyper-expression unmasks beta cells but not alpha cells to the immune system in pre-diabetes. (2021) (8)
- Human herpesvirus-6 is present at higher levels in the pancreatic tissues of donors with type 1 diabetes. (2019) (8)
- Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study (2019) (8)
- The Type 1 Diabetes Signature: Hardwired to Trigger Inflammation? (2014) (8)
- Antibody cross‐reactivity and the viral aetiology of type 1 diabetes (2013) (8)
- Can an immune-regulatory vaccine prevent HIV infection? (2012) (8)
- Clinical potential of antigen-specific therapies in type 1 diabetes. (2012) (8)
- Vaccination to prevent type 1 diabetes (2002) (7)
- Antigen-Specific Peptide Immunotherapy for Type 1 Diabetes: Proof of Safety, Hope for Efficacy. (2017) (7)
- Modification of yeast fructose-1,6-bisphosphatase. (1985) (7)
- Regulation of viral and autoimmune responses. (2003) (7)
- Immunology: insulin trigger for diabetes. (2005) (7)
- Metabolic syndrome – Removing roadblocks to therapy: Antigenic immunotherapies☆ (2014) (7)
- Repeat determination of left ventricular wall thickness from mass and volume during one cardiac cycle for the calculation of left ventricular wall stress parameters (1990) (7)
- Resuscitating adaptive Tregs with combination therapies? (2008) (6)
- Efficacy and safety of liraglutide in type 1 diabetes by baseline characteristics in the ADJUNCT ONE and ADJUNCT TWO randomized controlled trials (2021) (6)
- Multicomponent Plasmid Protects Mice From Spontaneous Autoimmune Diabetes. (2021) (6)
- Myocardial performance and efficiency as assessed by energetic parameters derived from pressure-volume relations and wall thickness in human ventricles. (1986) (6)
- Combination therapy with InsB9-23 peptide immunization and CTLA4-IgG does not reverse diabetes in NOD mice. (2012) (6)
- Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB) (2014) (5)
- Combination therapy with anti-CD6 and oral insulin immunization reverses recent onset diabetes in non obese diabetic mice but fails to induce lasting tolerance. (2013) (5)
- Current state of antigen-specific immunotherapy for type 1 diabetes (2021) (5)
- Immunotherapy after recent-onset type 1 diabetes: combinatorial treatment for achieving long-term remission in humans? (2004) (5)
- Oral insulin does not alter gut microbiota composition of NOD mice (2018) (5)
- Viruses and Type 1 diabetes: a dynamic labile equilibrium. (2013) (5)
- INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes (2022) (5)
- Minimal effect of CD103 expression on the control of a chronic antiviral immune response. (2010) (5)
- Limitations in immunotherapy with CD3 antibodies: comment on the article by Drs. Chatenoud and Bach. (2005) (4)
- The role of the activating receptor NKG2D in autoimmunity. (2009) (4)
- IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes. (2021) (4)
- Virally induced inflammation and therapeutic avenues in type 1 diabetes. (2004) (4)
- The shifting paradigm of a “cure” for type 1 diabetes: is technology replacing immune-based therapies? (2018) (4)
- Cure of Chronic Viral Infection and Virus-Induced Type 1 Diabetes by Neutralizing Antibodies (2006) (4)
- Temporal Intra-Individual Variation of Immunological Biomarkers in Type 1 Diabetes Patients: Implications for Future Use in Cross-Sectional Assessment (2013) (4)
- BDC12-4.1 T-Cell Receptor Transgenic Insulin-Specific CD4 T Cells Are Resistant to In Vitro Differentiation into Functional Foxp3+ T Regulatory Cells (2014) (4)
- Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes (2021) (4)
- Cytokines and chemokines in virus-induced autoimmunity. (2003) (4)
- Peripheral autoreactive CD8 T‐cell frequencies are too variable to be a reliable predictor of disease progression of human type 1 diabetes (2021) (4)
- Prophylaxis of autoimmune diabetes by antigen based immune modulation: are we there yet? (2004) (3)
- IL-7 receptor α blockade, an off-switch for autoreactive T cells (2012) (3)
- Insulin trigger for diabetes (2005) (3)
- Pathogenesis of type 1 diabetes: a viewpoint. (2004) (2)
- Effect of IL4 and IL10 on a human in vitro type 1 diabetes model. (2022) (2)
- The effect of Toll-like receptor stimulation on the motility of regulatory T cells. (2020) (2)
- Corona Pandemic: Assisted Isolation and Care to Protect Vulnerable Populations May Allow Us to Shorten the Universal Lock-Down and Gradually Re-open Society (2020) (2)
- First-Trimester Human Fetal Pancreas Transplantation for Type 1 Diabetes Treatment (2008) (2)
- Diabetes: A virus-gene collaboration. (2009) (2)
- Oxidative inactivation of yeast fructose-1,6-bisphosphatase. (1985) (2)
- IL-4R is expressed on alpha and beta cells of human pancreata. (2020) (2)
- Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes? (2021) (2)
- Stopping diabetes in its tracks: autologous non-myeloablative stem cell transplantation. (2007) (2)
- Long-term viability through selective permeability (2020) (2)
- How benign autoimmunity becomes detrimental in type 1 diabetes (2021) (2)
- Predictive, preventive and personalized medicine (PPPM) as a strategic avenue and global tool for advancing T1D-related care: Fundamental, Applied and Affiliated Issues (2014) (2)
- Immunoinformatics: an overview of computational tools and techniques for understanding immune function (2007) (1)
- Acute effects of nitrates on left ventricular performance and energetics. (1986) (1)
- OAS1 is not associated with MHC class I hyperexpression in the islets of donors with T1D regardless of disease duration. (2018) (1)
- Higher proinflammatory cytokine production and spontaneous activation in some type 1 and type 2 diabetic subjects. (2014) (1)
- Introduction (2007) (1)
- The urgent need for integrated science to fight COVID-19 pandemic and beyond (2020) (1)
- Immunosuppression in islet transplantation. (2008) (1)
- Selective immunotherapy of IDDM: a discussion based on new findings from the RIP-LCMV model for autoimmune diabetes. (1998) (1)
- Overexpression of HLA class I predominantly on alpha cell in at risk individuals for type 1 diabetes (2020) (1)
- Autoantibodies Exacerbate the Severity of MHV-Induced Encephalitis (2006) (0)
- [Introduction to preventive and predictive medicine: past experience and future reality]. (2012) (0)
- Faculty Opinions recommendation of Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates. (2018) (0)
- Faculty Opinions recommendation of Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample. (2021) (0)
- Design of immune-based interventions in autoimmunity and viral infections--the need for predictive models that integrate time, dose and classes of immune responses. (2001) (0)
- Faculty Opinions recommendation of CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes. (2020) (0)
- Faculty Opinions recommendation of Temporal analysis of amylase expression in control, autoantibody positive, and type 1 diabetes pancreatic tissues. (2019) (0)
- Faculty Opinions recommendation of Evidence of tissue repair in human donor pancreas after prolonged duration of stay in intensive care. (2020) (0)
- Faculty Opinions recommendation of Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes. (2020) (0)
- New trends in immunosuppression--sixth international congress. New drug candidates. 5-8 February 2004, Salzburg, Austria. (2004) (0)
- Liraglutide protects β-cells in novel human islet spheroid models of type 1 diabetes. (2022) (0)
- Keeping the patient perspective: Where are we in the world of type 1 diabetes? (2013) (0)
- Faculty Opinions recommendation of Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. (0)
- Erratum. Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes. Diabetes 2014;63:3880–3890 (2015) (0)
- InsB:9‐23 peptide‐based immunotherapy for type 1 diabetes; the immunization frequency and the state of the disease can alter the efficacy (2008) (0)
- List of Contributors (2020) (0)
- Response to Comment on Rodriguez-Calvo et al. Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes 2017;66:1334–1345 (2017) (0)
- Strategies to treat autoimmune diabetes (2007) (0)
- Defining optimal immunotherapies for type 1 diabetes. Introduction. (2008) (0)
- Faculty Opinions recommendation of Comprehensive proteomics analysis of stressed human islets identifies GDF15 as a target for type 1 diabetes intervention. (2020) (0)
- Faculty Opinions recommendation of Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes. (2020) (0)
- Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications (2018) (0)
- Interfacing dendritic and natural killer cells: a tool for targeted tolerance induction? (2003) (0)
- New horizons in biomarker research. (2015) (0)
- At long last: clinically significant immunomodulatory therapies (2007) (0)
- Induction of antigenic immune tolerance to delay type 1 diabetes - challenges for clinical translation. (2022) (0)
- Coupling between myocardial oxygen consumption and mechanics in patients with dilative cardiomyopathy. Influence of vasodilation and positive inotropism. (1989) (0)
- Generation and effector functions of regulatory lymphocytes (2002) (0)
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