Matthias Schwab
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German physician and university teacher
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(Suggest an Edit or Addition)According to Wikipedia, Matthias Schwab is a German doctor and university lecturer. He is director of the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology located on the campus of the Robert-Bosch-Hospital in Stuttgart, an institution of the Robert Bosch Stiftung, and holder of the Chair of Clinical Pharmacology at the University of Tübingen as well as Medical Director of the Department of Clinical Pharmacology at the University Hospital Tübingen.
Matthias Schwab 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. (2013) (2737)
- Metformin improves healthspan and lifespan in mice (2013) (1031)
- Reduced Paneth cell α-defensins in ileal Crohn's disease (2005) (870)
- Frequency of single nucleotide polymorphisms in the P‐glycoprotein drug transporter MDR1 gene in white subjects (2001) (747)
- NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression (2004) (730)
- Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. (2001) (618)
- Reduced Paneth cell alpha-defensins in ileal Crohn's disease. (2005) (584)
- A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. (2006) (584)
- A New Molecular Predictor of Distant Recurrence in ER-Positive, HER2-Negative Breast Cancer Adds Independent Information to Conventional Clinical Risk Factors (2011) (582)
- Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation (2008) (554)
- Sex is a major determinant of CYP3A4 expression in human liver (2003) (489)
- Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. (2007) (447)
- High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). (2004) (427)
- Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants. (2004) (415)
- Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. (2009) (390)
- The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells. (2001) (382)
- Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. (2008) (368)
- NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity (2016) (350)
- Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver (2009) (348)
- Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy. (2011) (347)
- Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process (2014) (346)
- Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update (2018) (335)
- Telomere length in different tissues of elderly patients (2000) (333)
- Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update (2019) (331)
- Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis. (2003) (327)
- Genetic polymorphisms of the human MDR1 drug transporter. (2003) (318)
- Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update (2013) (314)
- Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing (2013) (297)
- Frequency of C3435T polymorphism of MDR1 gene in African people (2001) (293)
- Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6. (2001) (287)
- Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia. (2005) (287)
- Treatment of chronic hepatitis D with the entry inhibitor myrcludex B: First results of a phase Ib/IIa study. (2016) (287)
- Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance. (2007) (283)
- Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz (2005) (281)
- Intraperitoneal Chemotherapy of Peritoneal Carcinomatosis Using Pressurized Aerosol as an Alternative to Liquid Solution: First Evidence for Efficacy (2013) (279)
- Predictive Value of Known and Novel Alleles of CYP2B6 for Efavirenz Plasma Concentrations in HIV‐infected Individuals (2007) (271)
- MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine. (2002) (265)
- Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma (2011) (261)
- Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine (2004) (260)
- Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism. (2002) (257)
- Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors. (2002) (255)
- The Paneth Cell α-Defensin Deficiency of Ileal Crohn’s Disease Is Linked to Wnt/Tcf-41 (2007) (244)
- Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data. (2015) (243)
- Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1 (2013) (242)
- Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis. (2009) (240)
- Clinical Pharmacokinetics and Use of Infliximab (2007) (238)
- Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. (2016) (237)
- Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease. (2011) (232)
- Aberrant Splicing Caused by Single Nucleotide Polymorphism c.516G>T [Q172H], a Marker of CYP2B6*6, Is Responsible for Decreased Expression and Activity of CYP2B6 in Liver (2008) (230)
- CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation. (2008) (222)
- ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation. (2005) (222)
- Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs. (2000) (214)
- Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy (2018) (213)
- Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium (2017) (208)
- From hype to reality: data science enabling personalized medicine (2018) (203)
- Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6. (2000) (201)
- Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis. (2014) (198)
- Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. (2013) (198)
- A novel intronic mutation, 2988G>A, with high predictivity for impaired dunction of cytochrome P450 2D6 in white subjects (2004) (192)
- Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin. (1993) (190)
- Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease. (2002) (183)
- Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature (2015) (183)
- Lipid-lowering response to statins is affected by CYP3A5 polymorphism. (2004) (181)
- Clinical aspects of the MDR1 (ABCB1) gene polymorphism. (2004) (178)
- CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Populations (2013) (176)
- Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial (2010) (175)
- First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B. (2016) (172)
- CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real‐rime PCR (2003) (169)
- CYP2C19 polymorphism and proton pump inhibitors. (2004) (166)
- The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. (2007) (165)
- Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer (2014) (157)
- Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects. (2013) (155)
- Safe treatment of thiopurine S-methyltransferase deficient Crohn’s disease patients with azathioprine (2003) (154)
- Pharmacogenomics of tamoxifen therapy. (2009) (149)
- DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma (2011) (147)
- Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease. (2010) (144)
- Multiple Novel Nonsynonymous CYP2B6 Gene Polymorphisms in Caucasians: Demonstration of Phenotypic Null Alleles (2004) (143)
- Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron (2017) (142)
- Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs) (2011) (142)
- Cyclophosphamide pharmacokinetics and dose requirements in patients with renal insufficiency. (2002) (141)
- Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study. (2010) (141)
- Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1). (2005) (140)
- PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo (2012) (140)
- Transporter-mediated protection against thiopurine-induced hematopoietic toxicity. (2008) (139)
- Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease (2009) (137)
- Thiopurine Treatment in Inflammatory Bowel Disease (2007) (135)
- Omics and drug response. (2013) (134)
- Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation. (2009) (132)
- Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17 (2005) (131)
- Topical delivery of therapeutic agents in the treatment of inflammatory bowel disease. (2005) (131)
- Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting (2016) (129)
- Pharmacogenetics of antimalarial drugs: effect on metabolism and transport. (2009) (128)
- Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: A prospective clinical study (2005) (123)
- Off label prescribing to children in primary care in Germany: retrospective cohort study (2002) (122)
- Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1). (2004) (117)
- Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing. (2007) (115)
- Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics. (2011) (115)
- Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine. (2002) (115)
- Neuroblastoma tumor cell-binding peptides identified through random peptide phage display. (2001) (114)
- In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency (2015) (111)
- Highly multiplexed genotyping of thiopurine s-methyltransferase variants using MALD-TOF mass spectrometry: reliable genotyping in different ethnic groups. (2008) (110)
- Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver (2011) (108)
- Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing (2020) (107)
- Intranasal Delivery of Bone Marrow-Derived Mesenchymal Stem Cells, Macrophages, and Microglia to the Brain in Mouse Models of Alzheimer's and Parkinson's Disease (2014) (107)
- Tamoxifen use in postmenopausal breast cancer: CYP2D6 matters. (2013) (106)
- Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid‐lowering efficacy of multiple‐dose pravastatin (2006) (106)
- A Natural CYP2B6 TATA Box Polymorphism (–82T→ C) Leading to Enhanced Transcription and Relocation of the Transcriptional Start Site (2005) (106)
- Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions. (2010) (106)
- CYP2C19 polymorphism is a major predictor of treatment failure in white patients by use of lansoprazole‐based quadruple therapy for eradication of Helicobacter Pylori (2004) (106)
- Expression of neurotransmitter receptors and myc protooncogenes in subclones of a human neuroblastoma cell line. (1987) (106)
- Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism. (2013) (103)
- Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes (2010) (102)
- Nomenclature for alleles of the thiopurine methyltransferase gene (2013) (102)
- Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians. (2003) (102)
- Circulating Lysophosphatidylcholines Are Markers of a Metabolically Benign Nonalcoholic Fatty Liver (2013) (101)
- UDP‐Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo (2010) (100)
- Organic Anion Transporters and Their Implications in Pharmacotherapy (2012) (100)
- Impaired expression of CYP2D6 in intermediate metabolizers carrying the *41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events (2006) (99)
- Final results of a multicenter, open-label phase 2b clinical trial to assess safety and efficacy of Myrcludex B in combination with Tenofovir in patients with chronic HBV/HDV co-infection (2018) (98)
- CYP2D6 Polymorphisms as Predictors of Outcome in Breast Cancer Patients Treated with Tamoxifen: Expanded Polymorphism Coverage Improves Risk Stratification (2010) (98)
- Developmental pharmacokinetics. (2011) (98)
- Variability in human hepatic MRP4 expression: influence of cholestasis and genotype (2008) (98)
- Detection of N-myc oncogene expression in human neuroblastoma by in situ hybridization and blot analysis: relationship to clinical outcome. (1986) (96)
- META-ANALYSIS OF CYP2D6 METABOLIZER PHENOTYPE AND METOPROLOL PHARMACOKINETICS (2013) (95)
- A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome (2015) (94)
- Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart. (2003) (91)
- Proximal femur fracture in older patients--rehabilitation and clinical outcome. (2003) (91)
- Mechanisms and assessment of statin‐related muscular adverse effects (2014) (90)
- Automated extraction of DNA and RNA from a single formalin-fixed paraffin-embedded tissue section for analysis of both single-nucleotide polymorphisms and mRNA expression. (2010) (89)
- DNA Methylation of the SLC16A3 Promoter Regulates Expression of the Human Lactate Transporter MCT4 in Renal Cancer with Consequences for Clinical Outcome (2013) (88)
- 6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease. (2005) (86)
- A phosphotyrosine switch regulates organic cation transporters (2016) (85)
- Genetic variation in human drug-related genes (2017) (85)
- Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator–Activated Receptor Alpha (PPARα) (2013) (84)
- Identification of Budesonide and Prednisone as Substrates of the Intestinal Drug Efflux Pump P-glycoprotein (2004) (83)
- Enduring and emerging challenges of informed consent. (2015) (83)
- Potential Role of CXCR4 Targeting in the Context of Radiotherapy and Immunotherapy of Cancer (2018) (83)
- High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC. (2001) (82)
- Intestinal absorption, metabolism, and excretion of (-)-epicatechin in healthy humans assessed by using an intestinal perfusion technique. (2013) (80)
- Effects of CYP2C9 polymorphisms on the pharmacokinetics of R- and S-phenprocoumon in healthy volunteers. (2004) (78)
- Genetic polymorphisms of glutathione S‐transferase A1, the major glutathione S‐transferase in human liver: Consequences for enzyme expression and busulfan conjugation (2002) (77)
- Evidence for morphine‐independent central nervous opioid effects after administration of codeine: Contribution of other codeine metabolites (2006) (77)
- Telomeres in Neonates: New Insights in Fetal Hematopoiesis (2001) (76)
- Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs (2008) (76)
- Expression of N-myc and c-src during the development of fetal human brain. (1987) (76)
- Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy (2018) (75)
- Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection (2009) (72)
- Three novel thiopurine S‐methyltransferase allelic variants (TPMT*20, *21, *22) – association with decreased enzyme function (2006) (72)
- Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms (2015) (71)
- A pilot ‘window of opportunity’ neoadjuvant study of metformin in localised prostate cancer (2014) (70)
- Adherence to thiopurine treatment in out‐patients with Crohn’s disease (2007) (70)
- Inflammation-Associated MicroRNA-130b Down-Regulates Cytochrome P450 Activities and Directly Targets CYP2C9 (2015) (70)
- 6-Thioguanine Treatment in Inflammatory Bowel Disease: A Critical Appraisal by a European 6-TG Working Party (2006) (69)
- Effect of comedication with proton pump inhibitors (PPIs) on post-interventional residual platelet aggregation in patients undergoing coronary stenting treated by dual antiplatelet therapy. (2010) (68)
- Cyclooxygenase-2 Expression in Human Colorectal Cancer Is Unrelated to Overall Patient Survival (2005) (68)
- Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans (2012) (68)
- Shortcoming in the diagnosis of TPMT deficiency in a patient with Crohn's disease using phenotyping only. (2001) (67)
- Therapeutic Efficacy and Safety of Amitriptyline in Patients with Cystic Fibrosis (2009) (67)
- Effects of the Selective α5-GABAAR Antagonist S44819 on Excitability in the Human Brain: A TMS–EMG and TMS–EEG Phase I Study (2016) (66)
- Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial (2014) (66)
- Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors. (2016) (65)
- 6‐Thioguanine — efficacy and safety in chronic active Crohn's disease (2003) (65)
- Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia (2018) (65)
- Expression of stromal cell-derived factor-1 receptors CXCR4 and CXCR7 on circulating platelets of patients with acute coronary syndrome and association with left ventricular functional recovery. (2014) (64)
- Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver (2010) (63)
- Systematic Review of Variations in Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Metastasis from Colorectal Cancer (2018) (62)
- Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1) (2013) (61)
- Association of SGK1 Gene Polymorphisms with Type 2 Diabetes (2008) (60)
- Selective Induction of Human Hepatic Cytochromes P450 2B6 and 3A4 by Metamizole (2007) (60)
- Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry (2019) (59)
- Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes. (2016) (59)
- 6‐mercaptopurine and 9‐(2‐phosphonyl‐methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4 (2008) (58)
- Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest. (2016) (58)
- Development of the PGx‐Passport: A Panel of Actionable Germline Genetic Variants for Pre‐Emptive Pharmacogenetic Testing (2019) (58)
- The NTCP‐inhibitor Myrcludex B: Effects on Bile Acid Disposition and Tenofovir Pharmacokinetics (2018) (57)
- Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs. (2008) (55)
- Effects of atorvastatin metabolites on induction of drug‐metabolizing enzymes and membrane transporters through human pregnane X receptor (2012) (55)
- GSTP1 and MDR1 Genotypes and Central Nervous System Relapse in Childhood Acute Lymphoblastic Leukemia (2005) (55)
- Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin (2009) (54)
- Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry. (2012) (54)
- DNA Methylation of ADME Genes (2016) (54)
- Influence of 5‐aminosalicylic acid on 6‐thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy (2010) (54)
- Survival Prediction of Clear Cell Renal Cell Carcinoma Based on Gene Expression Similarity to the Proximal Tubule of the Nephron. (2015) (54)
- Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics (2011) (53)
- Adverse Drug Reactions (ADR) and Emergencies. (2018) (52)
- Prediction of tamoxifen outcome by genetic variation of CYP2D6 in post-menopausal women with early breast cancer. (2014) (52)
- Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans. (2015) (51)
- Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine (2016) (51)
- Heritability of metoprolol and torsemide pharmacokinetics (2015) (51)
- Renal tubular transport and the genetic basis of hypertensive disease (2005) (50)
- Cohort profile: Greifswald approach to individualized medicine (GANI_MED) (2014) (49)
- The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets (2021) (49)
- A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL (2003) (49)
- Functional genomics suggest neurogenesis in the adult human olfactory bulb (2014) (49)
- Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics (2015) (48)
- Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease (2012) (48)
- Serum Procalcitonin Differentiates Inflammatory Bowel Disease and Self-limited Colitis (2004) (47)
- Pharmacogenomic Polygenic Response Score Predicts Ischemic Events and Cardiovascular Mortality in Clopidogrel-Treated Patients. (2019) (47)
- A novel functional polymorphism in the transforming growth factor-beta2 gene promoter and tumor progression in breast cancer. (2006) (45)
- Remission maintenance by tioguanine in chronic active Crohn's disease (2003) (45)
- Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial (2016) (45)
- Gastrointestinal stromal tumors of the esophagus: evaluation of a pooled case series regarding clinicopathological features and clinical outcome. (2015) (45)
- Down syndrome, transient myeloproliferative disorder, and infantile liver fibrosis. (1998) (44)
- A Variant of the SLC10A2 Gene Encoding the Apical Sodium-Dependent Bile Acid Transporter Is a Risk Factor for Gallstone Disease (2009) (44)
- Effects of aminosalicylates on thiopurine S‐methyltransferase activity: an ex vivo study in patients with inflammatory bowel disease (2005) (44)
- Pharmacogenomics education in medical and pharmacy schools: conclusions of a global survey. (2019) (44)
- CYP3A5 Genotype is Associated with Diagnosis of Hypertension in Elderly Patients (2005) (44)
- Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols. (2006) (43)
- Selective Inhibition of the Lactate Transporter MCT4 Reduces Growth of Invasive Bladder Cancer (2018) (43)
- ABCB1 Single‐Nucleotide Polymorphisms Determine Tacrolimus Response in Patients With Ulcerative Colitis (2011) (43)
- Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen (2017) (43)
- Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data. (2005) (42)
- Pharmacogene Variation Consortium Gene Introduction: NUDT15 (2018) (42)
- Role of ABC transporters in fluoropyrimidine-based chemotherapy response. (2015) (42)
- MALDI-TOF mass spectrometry for multiplex genotyping of CYP2B6 single-nucleotide polymorphisms. (2007) (42)
- Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST) (2015) (41)
- Population pharmacokinetics of oral busulfan in children (2002) (41)
- Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics. (2007) (41)
- Thioguanine‐nucleotides do not predict efficacy of tioguanine in Crohn's disease (2004) (41)
- Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling (2020) (41)
- Monitoring of Thiopurine Methyltransferase Activity in Postsurgical Patients With Crohn's Disease During 1 Year of Treatment With Azathioprine or Mesalazine (2007) (40)
- Retigabine/Ezogabine, a KCNQ/KV7 channel opener: pharmacological and clinical data (2012) (40)
- Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites. (2012) (40)
- Quantitative bile acid profiling by liquid chromatography quadrupole time-of-flight mass spectrometry: monitoring hepatitis B therapy by a novel Na+-taurocholate cotransporting polypeptide inhibitor (2015) (40)
- Sensitive quantification of omeprazole and its metabolites in human plasma by liquid chromatography-mass spectrometry. (2006) (39)
- Dihydropyrimidine Dehydrogenase Testing prior to Treatment with 5-Fluorouracil, Capecitabine, and Tegafur: A Consensus Paper (2020) (39)
- Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta‐Analysis of Three Genome‐Wide Association Studies (2017) (39)
- Comprehensive Metabolomic and Lipidomic Profiling of Human Kidney Tissue: A Platform Comparison. (2017) (38)
- A Predominate Role of CYP1A2 for the Metabolism of Nabumetone to the Active Metabolite, 6-Methoxy-2-naphthylacetic Acid, in Human Liver Microsomes (2009) (38)
- The pharmacogenetics of methotrexate in inflammatory bowel disease (2005) (36)
- Differential Expression of Drug Uptake and Efflux Transporters in Japanese Patients with Hepatocellular Carcinoma (2014) (36)
- Inhibition of human CYP2B6 by N,N',N''-triethylenethiophosphoramide is irreversible and mechanism-based. (2005) (36)
- Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research (2014) (35)
- Sensitive and rapid quantification of busulfan in small plasma volumes by liquid chromatography-electrospray mass spectrometry. (2001) (35)
- Activating Mutation of the Renal Epithelial Chloride Channel ClC-Kb Predisposing to Hypertension (2004) (35)
- OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. (2017) (35)
- a proof-of-concept Phase 2a clinical trial with Hbv/hdv entry inhibitor Myrcludex B : lb-20 (2014) (35)
- Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice (2004) (34)
- Psychotropic drug use, falls and hip fracture in the elderly (2000) (34)
- Evaluation of Clinical Risk Factors to Predict High On-Treatment Platelet Reactivity and Outcome in Patients with Stable Coronary Artery Disease (PREDICT-STABLE) (2015) (34)
- Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis (2011) (34)
- Characterization of the breast cancer resistance protein (BCRP/ABCG2) in clear cell renal cell carcinoma (2018) (34)
- Data collection as a barrier to personalized medicine. (2015) (34)
- The pharmacogenetics of methotrexate in inflammatory bowel disease. (2005) (34)
- Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy. (2018) (34)
- Phase I study of domatinostat (4SC‐202), a class I histone deacetylase inhibitor in patients with advanced hematological malignancies (2019) (34)
- Clinical Course and Long-Term Outcome of Hantavirus-Associated Nephropathia Epidemica, Germany (2015) (33)
- Intranasal Administration of Mesenchymal Stem Cells Ameliorates the Abnormal Dopamine Transmission System and Inflammatory Reaction in the R6/2 Mouse Model of Huntington Disease (2019) (33)
- Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors (2015) (33)
- Metabolic and Lipidomic Reprogramming in Renal Cell Carcinoma Subtypes Reflects Regions of Tumor Origin. (2018) (33)
- From genomic medicine to precision medicine: highlights of 2015 (2016) (33)
- Neuroprotective, Neurogenic, and Amyloid Beta Reducing Effect of a Novel Alpha 2-Adrenoblocker, Mesedin, on Astroglia and Neuronal Progenitors upon Hypoxia and Glutamate Exposure (2017) (33)
- A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort (2019) (33)
- TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease. (2014) (33)
- Use of Aminoglycosides in Elderly Patients (1997) (32)
- Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms (2012) (32)
- Using trade names: a risk factor for accidental drug overdose. (2002) (32)
- Pharmacogenomics: a key component of personalized therapy (2012) (31)
- Acute kidney injury and tools for risk-stratification in 456 patients with hantavirus-induced nephropathia epidemica. (2015) (31)
- Frequence, Spectrum and Prognostic Impact of Additional Malignancies in Patients With Gastrointestinal Stromal Tumors1234 (2015) (31)
- Age-Dependent Astroglial Vulnerability to Hypoxia and Glutamate: The Role for Erythropoietin (2013) (30)
- Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes (2016) (30)
- Genetic variation of platelet function and pharmacology: An update of current knowledge (2013) (30)
- Enantioselective quantitation of the ecstasy compound (R)- and (S)-N-ethyl-3,4-methylenedioxyamphetamine and its major metabolites in human plasma and urine. (2003) (30)
- Personalized cardiovascular medicine: concepts and methodological considerations (2013) (30)
- Oncogenic Stress Induced by Acute Hyper-Activation of Bcr-Abl Leads to Cell Death upon Induction of Excessive Aerobic Glycolysis (2011) (30)
- Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities (2019) (29)
- Impact of point-of-care testing for CYP2C19 on platelet inhibition in patients with acute coronary syndrome and early dual antiplatelet therapy in the emergency setting. (2014) (29)
- Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs (2012) (29)
- Stratified medicine for the use of antidiabetic medication in treatment of type II diabetes and cancer: where do we go from here? (2015) (28)
- Drug-induced acid-base disorders (2015) (28)
- Detection of Rearrangements and Transcriptional Up-Regulation of ALK in FFPE Lung Cancer Specimens Using a Novel, Sensitive, Quantitative Reverse Transcription Polymerase Chain Reaction Assay (2014) (28)
- Molecular signature of human bone marrow-derived mesenchymal stromal cell subsets (2019) (28)
- Identification of cardiomyopathy associated circulating miRNA biomarkers in patients with muscular dystrophy using a complementary cardiovascular magnetic resonance and plasma profiling approach (2016) (27)
- Impact of counterbalance between macrophage migration inhibitory factor and its inhibitor Gremlin-1 in patients with coronary artery disease. (2014) (27)
- Determination of 6-Thioguanosine Diphosphate and Triphosphate and Nucleoside Diphosphate Kinase Activity in Erythrocytes: Novel Targets for Thiopurine Therapy? (2010) (27)
- Impact of p38 MAP Kinase Inhibitors on LPS-Induced Release of TNF-α in Whole Blood and Primary Cells from Different Species (2015) (27)
- NOD2/CARD15 Gene Variants Are Linked to Failure of Antibiotic Treatment in Perianal Fistulating Crohn's Disease (2008) (27)
- MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma (2015) (27)
- Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study (2006) (27)
- Platelet surface expression of stromal cell–derived factor‐1 receptors CXCR4 and CXCR7 is associated with clinical outcomes in patients with coronary artery disease (2015) (26)
- Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process. (2018) (26)
- A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis. (2005) (26)
- Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole (2019) (26)
- A brighter future for the implementation of pharmacogenomic testing (2016) (25)
- Toxicity and pharmacokinetics of i.v. busulfan in children before stem cell transplantation (2005) (25)
- Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction. (2002) (25)
- Impact of Vitamin D Receptor VDR rs2228570 Polymorphism in Oldest Old (2013) (25)
- Comparison of Different Risk Classification Systems in 558 Patients with Gastrointestinal Stromal Tumors after R0-Resection (2016) (25)
- Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2 (2016) (25)
- Intranasal Losartan Decreases Perivascular Beta Amyloid, Inflammation, and the Decline of Neurogenesis in Hypertensive Rats (2019) (25)
- Polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy of patients with primary invasive breast cancer (2007) (25)
- Thiopurine S-methyltransferase as a target for drug interactions (2005) (24)
- Genome Medicine: past, present and future (2011) (24)
- Esomeprazole‐induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: Evidence from clinical and pharmacokinetic data (2005) (24)
- Effects of rifampicin on global gene expression in human small intestine (2007) (24)
- PDK1 Determines Collagen-Dependent Platelet Ca2+ Signaling and Is Critical to Development of Ischemic Stroke In Vivo (2016) (23)
- Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy (2020) (23)
- Impact of metabolizing enzymes on drug response of endocrine therapy in breast cancer (2013) (23)
- Personalized laboratory medicine: a patient-centered future approach (2018) (23)
- Simultaneous quantitative analysis of letrozole, its carbinol metabolite, and carbinol glucuronide in human plasma by LC-MS/MS (2012) (23)
- A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6 (2006) (23)
- Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates (2020) (23)
- Carboxymefloquine, the Major Metabolite of the Antimalarial Drug Mefloquine, Induces Drug-Metabolizing Enzyme and Transporter Expression by Activation of Pregnane X Receptor (2014) (23)
- Physiologically‐Based Pharmacokinetic Models for CYP1A2 Drug–Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam (2019) (22)
- Genome‐wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC) (2017) (22)
- Mutational analysis of the human dihydropyrimidine dehydrogenase gene by denaturing high-performance liquid chromatography. (2003) (22)
- The earwax-associated SNP c.538G>A (G180R) in ABCC11 is not associated with breast cancer risk in Europeans (2011) (22)
- The Impact of Thyroid Disease on the Regulation, Expression, and Function of ABCB1 (MDR1/P Glycoprotein) and Consequences for the Disposition of Digoxin (2010) (22)
- Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium (2020) (22)
- Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins (2009) (22)
- Clinical Relevance of CYP2D6 Genetics for Tamoxifen Response in Breast Cancer (2008) (21)
- Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function (2009) (21)
- Mutation screening of apical sodium-dependent bile acid transporter (SLC10A2): novel haplotype block including six newly identified variants linked to reduced expression (2009) (21)
- The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes (2015) (21)
- Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by liquid chromatography/tandem mass spectrometry. (2014) (21)
- Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk (2010) (20)
- Human Pregnane X Receptor Genotype of the Donor but Not of the Recipient Is a Risk Factor for Delayed Graft Function After Renal Transplantation (2012) (20)
- Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients (2016) (20)
- Human Sterol Regulatory Element-Binding Protein 1a Contributes Significantly to Hepatic Lipogenic Gene Expression (2015) (20)
- A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients (2021) (19)
- Clinical outcome and global gene expression data support the existence of the estrogen receptor-negative/progesterone receptor-positive invasive breast cancer phenotype (2015) (19)
- Patient Education in a 14-month Randomised Trial Fails to Improve Adherence in Ulcerative Colitis: Influence of Demographic and Clinical Parameters on Non-adherence (2017) (19)
- Variants of PEAR1 Are Associated With Outcome in Patients With ACS and Stable CAD Undergoing PCI (2018) (19)
- Selective p38α MAP kinase/MAPK14 inhibition in enzymatically modified LDL‐stimulated human monocytes: implications for atherosclerosis (2017) (19)
- Platelet expression of transforming growth factor beta 1 is enhanced and associated with cardiovascular prognosis in patients with acute coronary syndrome. (2014) (19)
- Genetic Biomarkers in Epilepsy (2014) (19)
- Propafenone for the Prevention of Atrial Tachyarrhythmias After Cardiac Surgery: A Randomized, Double‐blind Placebo‐controlled Trial (2008) (18)
- Clinical impacts of histological subtyping primary breast cancer. (2010) (18)
- Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner (2016) (18)
- Population Pharmacokinetics of the BEACOPP Polychemotherapy Regimen in Hodgkin’s Lymphoma and its Effect on Myelotoxicity (2007) (18)
- Sorafenib Activity and Disposition in Liver Cancer Does Not Depend on Organic Cation Transporter 1 (2020) (18)
- Mucosal Improvement in Patients With Moderate to Severe Postoperative Endoscopic Recurrence of Crohn’s Disease and Azathioprine Metabolite Levels (2013) (18)
- Pharmacoresponse in genetic generalized epilepsy: a genome-wide association study. (2020) (18)
- Testing association of rare genetic variants with resistance to three common antiseizure medications (2020) (17)
- Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study (2020) (17)
- The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center (2019) (17)
- Clinical Trial: CYP2D6 Related Dose Escalation of Tamoxifen in Breast Cancer Patients With Iranian Ethnic Background Resulted in Increased Concentrations of Tamoxifen and Its Metabolites (2019) (17)
- Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8 (2015) (17)
- Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe (2015) (17)
- A Clinical Drug‐Drug Interaction Study Assessing a Novel Drug Transporter Phenotyping Cocktail With Adefovir, Sitagliptin, Metformin, Pitavastatin, and Digoxin (2019) (17)
- Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor (2017) (16)
- Germline variant burden in multidrug resistance transporters is a therapy‐specific predictor of survival in breast cancer patients (2020) (16)
- Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells (2012) (16)
- Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high–pressure liquid chromatography–electrospray ionization tandem mass spectrometry (2005) (16)
- Telomerase Activity in Cell Lines of Pediatric Soft Tissue Sarcomas (2003) (16)
- A multiplex MALDI-TOF MS approach facilitates genotyping of DNA from formalin-fixed paraffin-embedded tumour specimens (2010) (16)
- Designer Thiopurine-analogues for Optimised Immunosuppression in Inflammatory Bowel Diseases. (2016) (16)
- A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer. (2008) (16)
- Cell motility and migration as determinants of stem cell efficacy (2020) (16)
- Visual disorders associated with omeprazole and their relation to CYP2C19 polymorphism. (2002) (15)
- Association of CYP2C19*2 and associated haplotypes with lower norendoxifen concentrations in tamoxifen-treated Asian breast cancer patients. (2016) (15)
- Impact of the serum‐ and glucocorticoid‐inducible kinase 1 on platelet dense granule biogenesis and secretion (2015) (15)
- ABCC11/MRP8 polymorphisms affect 5-fluorouracil-induced severe toxicity and hepatic expression. (2013) (15)
- Postoperative survival of lung cancer patients: are there predictors beyond TNM? (2013) (15)
- Variability and Heritability of Thiamine Pharmacokinetics With Focus on OCT1 Effects on Membrane Transport and Pharmacokinetics in Humans (2020) (15)
- Obesity alters endoxifen plasma levels in young breast cancer patients: A pharmacometric simulation approach. (2020) (15)
- SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells. (2020) (15)
- Highly sensitive simultaneous quantification of estrogenic tamoxifen metabolites and steroid hormones by LC-MS/MS (2015) (15)
- LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma (2014) (15)
- Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry. (2003) (15)
- Concomitant use of tamoxifen and endoxifen in postmenopausal early breast cancer: prediction of plasma levels by physiologically-based pharmacokinetic modeling (2014) (14)
- Mechanisms of Clinical Resistance to Small Molecule Tyrosine Kinase Inhibitors Targeting Oncogenic Tyrosine Kinases (2005) (14)
- Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds (2006) (14)
- Physiologically Based Precision Dosing Approach for Drug‐Drug‐Gene Interactions: A Simvastatin Network Analysis (2020) (14)
- Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P‐Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What? (2018) (14)
- Pediatric clinical pharmacology (2011) (14)
- Personalising drug safety—results from the multi-centre prospective observational study on Adverse Drug Reactions in Emergency Departments (ADRED) (2019) (14)
- Platelet pharmacogenomics (2010) (14)
- Quantification of clomiphene metabolite isomers in human plasma by rapid-resolution liquid chromatography–electrospray ionization–tandem mass spectrometry (2011) (14)
- The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer (2019) (14)
- Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles (2018) (14)
- Identification of Cardiomyopathy-Associated Circulating miRNA Biomarkers in Muscular Dystrophy Female Carriers Using a Complementary Cardiac Imaging and Plasma Profiling Approach (2018) (14)
- Enzymatically Modified Low‐Density Lipoprotein Is Present in All Stages of Aortic Valve Sclerosis: Implications for Pathogenesis of the Disease (2015) (13)
- The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes (2017) (13)
- Epigenetics in Drug Response (2016) (13)
- Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma (2018) (13)
- Looking back at genomic medicine in 2011 (2012) (13)
- Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS (2020) (13)
- Pretreatment determination of TPMT – state of the art in clinical practice (2009) (13)
- Tamoxifen Pharmacogenetics and Metabolism: The Same Is Not the Same. (2019) (13)
- CYP2C19 genotype and outcomes of clopidogrel treatment. (2011) (12)
- Transport studies with 5-aminosalicylate (2006) (12)
- Prevention of falls in elderly people (1999) (12)
- Achieving the World Health Organization's vision for clinical pharmacology (2016) (12)
- Clinically-relevant OATP2B1 inhibitors in marketed drug space. (2019) (12)
- The limited impact of CYP3A5 genotype for the pharmacokinetics of CYP3A substrates (2007) (12)
- Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions (2020) (11)
- Sex Is a Major Determinant in Human (2003) (11)
- Infliximab treatment induces levels of the active azathioprine metabolite TGTP in Crohn's disease. (2013) (11)
- 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two (2016) (11)
- Translational learning from clinical studies predicts drug pharmacokinetics across patient populations (2017) (11)
- The importance of drug transporter characterization to precision medicine (2017) (11)
- Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling (2016) (11)
- Organic cation transporter pharmacogenomics and drug–drug interaction (2010) (10)
- Losartan Improves Memory, Neurogenesis and Cell Motility in Transgenic Alzheimer’s Mice (2021) (10)
- Interaction of Remdesivir with Clinically Relevant Hepatic Drug Uptake Transporters (2021) (10)
- Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension. (2006) (10)
- Tubular breast cancer. A retrospective study. (2014) (10)
- Prevention of fluoropyrimidine toxicity: do we still have to try our patient's luck? (2016) (10)
- Open letter on access to the BIA 10-2474 clinical trial data (2017) (10)
- The fruit fly Drosophila melanogaster as an innovative preclinical ADME model for solute carrier membrane transporters, with consequences for pharmacology and drug therapy. (2018) (10)
- Increased number of hip fractures (1999) (10)
- Gene Expression Signatures of BRCAness and Tumor Inflammation Define Subgroups of Early-Stage Hormone Receptor–Positive Breast Cancer Patients (2020) (10)
- Pharmacogenetics: Implications for Modern Type 2 Diabetes Therapy. (2015) (10)
- Rationale for the use of tyrosine kinase inhibitors in the treatment of paediatric desmoid-type fibromatosis (2021) (10)
- Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters (2016) (10)
- PXR Variants and Artemisinin Use in Vietnamese Subjects: Frequency Distribution and Impact on the Interindividual Variability of CYP3A Induction by Artemisinin (2012) (10)
- 504 A Double-Blind, Double-Dummy, Randomized, Controlled, Multicenter Trial On the Efficacy and Safety of Azathioprine Vs mesalamine for Prevention of Clinical Relapses in Crohn's Disease Patients with Postoperative Moderate or Severe Endoscopic Recurrence (2008) (10)
- SDF1 Polymorphisms Influence Outcome in Patients with Symptomatic Cardiovascular Disease (2016) (10)
- Optimized protocol for metabolomic and lipidomic profiling in formalin-fixed paraffin-embedded kidney tissue by LC-MS. (2020) (10)
- Ten years of Genome Medicine (2019) (9)
- OCT (SLC22A) and OCTN Family (2013) (9)
- Drug-induced hyponatraemia in elderly patients. (1999) (9)
- Adverse Drug Reactions in the Emergency Department: Is There a Role for Pharmacogenomic Profiles at Risk?—Results from the ADRED Study (2020) (9)
- Genetic and Epigenetic Regulation of Organic Cation Transporters. (2021) (9)
- Prevalence of a First-Degree Relative with Colorectal Cancer and Uptake of Screening Among Persons 40 to 54 Years Old. (2019) (9)
- Assessment of concomitant non-oncologic medication in patients with surgically treated renal cell carcinoma: impact on prognosis, cell-cycle progression and proliferation (2019) (9)
- Simultaneous Extraction of RNA and Metabolites from Single Kidney Tissue Specimens for Combined Transcriptomic and Metabolomic Profiling. (2018) (9)
- The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study (2020) (9)
- Warfarin pharmacogenetics meets clinical use (2011) (9)
- Direct Transcriptional Regulation of Human Hepatic Cytochrome P 450 3 A 4 ( CYP 3 A 4 ) by Peroxisome Proliferator – Activated Receptor Alpha ( PPAR a ) s (2013) (9)
- Ligand‐dependent and ‐independent regulation of human hepatic sphingomyelin phosphodiesterase acid‐like 3A expression by pregnane X receptor and crosstalk with liver X receptor (2017) (8)
- Cholestatic Liver Disease after Rituximab and Adalimumab and the Possible Role of Cross-Reacting Antibodies to Fab 2 Fragments (2013) (8)
- Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression (2019) (8)
- Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin (2020) (8)
- Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia (2021) (8)
- Interplay between Endothelin and Erythropoietin in Astroglia: The Role in Protection against Hypoxia (2014) (8)
- ADME Pharmacogenetics and Its Impact on Drug–Drug Interactions (2010) (8)
- HETEROGENEITY OF DRUG RESPONSES AND INDIVIDUALIZATION OF THERAPY (2009) (8)
- Implementation of a companion diagnostic in the clinical laboratory: the BRAF example in melanoma. (2015) (7)
- Association of SGK 1 Gene polymorphisms with type 2 diabetes (2008) (7)
- EPMA-World Congress 2015 (2016) (7)
- The Letrozole Phase 1 Metabolite Carbinol as a Novel Probe Drug for UGT2B7 (2013) (7)
- 2012 highlights in translational 'omics (2013) (7)
- A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study (2023) (7)
- Population pharmacokinetics of cyclophosphamide, doxorubicin and etoposide in 30 patients with BEACOPP chemotherapy. (2002) (7)
- Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups (2022) (7)
- Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans (2020) (7)
- Modulating endothelial adhesion and migration impacts stem cell therapies efficacy (2020) (7)
- Study protocol of the RaPS study: novel risk adapted prevention strategies for people with a family history of colorectal cancer (2018) (7)
- Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant (2015) (6)
- A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine (2014) (6)
- Second-generation colon capsule endoscopy for detection of colorectal polyps: Systematic review and meta-analysis of clinical trials (2021) (6)
- Imaging , Diagnosis , Prognosis A New Molecular Predictor of Distant Recurrence in ER-Positive , HER 2-Negative Breast Cancer Adds Independent Information to Conventional Clinical Risk Factors (2011) (6)
- Hypertonicity-Affected Genes Are Differentially Expressed in Clear Cell Renal Cell Carcinoma and Correlate with Cancer-Specific Survival (2019) (6)
- 6-thioguanine-buried alive? (2004) (6)
- The cytosolic isoform of glutaredoxin 2 promotes cell migration and invasion. (2020) (6)
- GPla Polymorphisms Are Associated with Outcomes in Patients at High Cardiovascular Risk (2017) (6)
- A Web-based survey among adults aged 40-54 years was time effective and yielded stable response patterns. (2019) (6)
- Two experts and a newbie: [18F]PARPi vs [18F]FTT vs [18F]FPyPARP—a comparison of PARP imaging agents (2021) (6)
- Correction: p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation (2016) (5)
- Platelet surface expression of cyclophilin A is associated with increased mortality in patients with symptomatic coronary artery disease (2020) (5)
- Combination of high on-treatment platelet aggregation and low deaggregation better predicts long-term cardiovascular events in PCI patients under dual antiplatelet therapy (2014) (5)
- Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm (2021) (5)
- Letter to the Editors Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO 1 B 1 gene ( encoding OATP 1 B 1 ) (2005) (5)
- Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins (2021) (5)
- Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor (2021) (5)
- Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancer. (2022) (5)
- Reply to A.-S. Dieudonné et al and J.M. Rae et al. (2013) (5)
- Is laboratory medicine ready for the era of personalized medicine? A survey addressed to laboratory directors of hospitals/academic schools of medicine in Europe (2015) (5)
- No association between the presence of killer-cell immunoglobulin-like receptor genes and susceptibility to childhood ALL. (2015) (5)
- Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver (2020) (5)
- Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs. (2020) (5)
- Novel models for the prediction of drug–gene interactions (2021) (5)
- Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation (2022) (5)
- Is Mistletoe Treatment Beneficial in Invasive Breast Cancer? A New Approach to an Unresolved Problem. (2018) (5)
- A Predominate Role of CYP 1 A 2 for the Metabolism of Nabumetone to the Active Metabolite , 6-Methoxy-2-naphthylacetic Acid , in Human Liver Microsomes (2009) (5)
- Prevalence of Psychotropic Drugs in Cases of Severe Adverse Drug Reactions Leading to Unplanned Emergency Visits in General Hospitals (2020) (5)
- Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma (2022) (4)
- Ileal Crohn's Disease Is Linked to Wnt/Tcf-4 -Defensin Deficiency of a The Paneth Cell (2007) (4)
- CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System—Results From the ADRED Study (2021) (4)
- Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies (2021) (4)
- α2-Adrenergic Receptor in Liver Fibrosis: Implications for the Adrenoblocker Mesedin (2020) (4)
- Phenprocoumon-induced hepatitis as an immunologically mediated drug allergic complication of antithrombotic therapy (2003) (4)
- Conventional Clinical Risk Factors HER 2-Negative Breast Cancer Adds Independent Information to A New Molecular Predictor of Distant Recurrence in ER-Positive (2011) (4)
- Pediatric Pharmacotherapy (2020) (4)
- MALDI-TOF mass spectrometry screening of cholelithiasis risk markers in the gene of HNF1alpha. (2012) (4)
- External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease (2021) (4)
- [Pharmacogenomics: hype or hope?]. (2011) (4)
- Cyclin D1 Over-Expressing Mantle Cell Lymphoma Cells Are Hypersensitive to Inhibition of Fatty Acid Synthase (FASN) (2011) (4)
- Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a prospective multicentre cohort study (2022) (4)
- Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3 (2019) (4)
- Reduced Paneth Cell &agr;-Defensins and Antimicrobial Activity in Ileal Crohn's Disease (2006) (4)
- ABCC2 and clinical outcome of tamoxifen therapy. (2010) (4)
- Tri‐Allelic Haplotypes Determine and Differentiate Functionally Normal Allele CYP2D6*2 and Impaired Allele CYP2D6*41 (2020) (4)
- Quantifying the Effect of Covariates on Concentrations and Effects of Steady-State Phenprocoumon Using a Population Pharmacokinetic/Pharmacodynamic Model (2013) (4)
- Prolonged Exposure to Oxaliplatin during HIPEC Improves Effectiveness in a Preclinical Micrometastasis Model (2022) (4)
- ABCB 1 Single-Nucleotide Polymorphisms Determine Tacrolimus Response in Patients With Ulcerative colitis (2011) (4)
- Comment on “Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin” (2017) (3)
- Challenges and opportunities associated with rare-variant pharmacogenomics. (2022) (3)
- Molecular signature of human bone marrow-derived mesenchymal stromal cell subsets (2019) (3)
- (Z)-Endoxifen and Early Recurrence of Breast Cancer: An Explorative Analysis in a Prospective Brazilian Study (2022) (3)
- The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes (2015) (3)
- Metformin and biomarkers relevant to neoplasia in nondiabetic patients. (2013) (3)
- Identification and characterization of novel splice variants of human farnesoid X receptor. (2021) (3)
- How paediatric drug development and use could benefit from OMICs: A c4c expert group white paper (2022) (3)
- Prevention of fluoropyrimidine toxicity: do we still have to try our patient's luck? (2017) (3)
- Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate (2017) (3)
- Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S‐Methyltransferase (2022) (3)
- CORRIGENDUM: Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium (2017) (3)
- Neural correlates of error monitoring modulated by atomoxetine in healthy volunteers: a randomized, placebo-controlled fMRI-study (2011) (3)
- A human ex vivo coculture model to investigate peritoneal metastasis and innovative treatment options (2021) (3)
- Stereoselective quantification of phase 1 and 2 metabolites of clomiphene in human plasma and urine. (2021) (3)
- Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment (2021) (2)
- p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation (2016) (2)
- Abstract LB-183: The predictive value of CYP2D6 genotypes for plasma levels of active tamoxifen metabolites in early breast cancer (2010) (2)
- Selective Protection of Human Liver Tissue in TNF-Targeting of Cancers of the Liver by Transient Depletion of Adenosine Triphosphate (2012) (2)
- Pharmacokinetics and pharmacodynamics of thiopurines in an in vitro model of human hepatocytes: Insights from an innovative mass spectrometry assay. (2017) (2)
- Myrcludex B : a first-inhuman clinical study with a first-in-class hepatitis B and hepatitis D virus entry inhibitor (2016) (2)
- 503 Alteration of Thiopurinephosphate Metabolite Levels By Aminosalicylates in IBD-Patients (2008) (2)
- Short-term oxaliplatin exposure according to established hyperthermic intraperitoneal chemotherapy (HIPEC) protocols lacks effectiveness in vitro and ex vivo (2019) (2)
- Comprar Pediatric Clinical Pharmacology (Handbook Of Experimental Pharmacology, Vol. 205) | Hanssjorg W. Seyberth | 9783642201943 | Springer (2011) (2)
- Supplementary Figures 1-18 (2010) (2)
- Combination of the Hepatitis B/D Entry Inhibitor Myrcludex B and Tenofovir: Assessment of the Effect on Plasma Bile Acid Profiles and Tenofovir Pharmacokinetics (2016) (2)
- Gastrointestinal side effects of azathioprine in patients with inflammatory bowel disease are not related to thiopurine methyltransferase polymorphism (2000) (2)
- Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon (2018) (2)
- A mosaic renal myeloid subtype with T-cell inhibitory and protumoral features is linked to immune escape and survival in clear cell renal cell cancer (2020) (2)
- Response: ClC-Kb Mutation Revisited (2006) (2)
- Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation. (2022) (2)
- Limited Association of the 2988g>a Single Nucleotide Polymorphism with CYP2D6*41 in Black Subjects: Reply (2005) (2)
- Interim results of a Phase Ib / IIa study of the entry inhibitor myrcludex B in chronic hepatitis D infected patients (2016) (2)
- DETERMINANTS OF NON‐RESPONSE IN HELICOBACTER PYLORI ERADICATION TRIALS (2005) (2)
- P1-06-26: The EndoPredict Score Is a Response Predictor for Neoadjuvant Chemotherapy in ER-Positive, HER2−Negative Breast Cancer. (2011) (2)
- Historical development of pediatric pharmacology. (2011) (2)
- The Membrane Transporter OAT7 (SLC22A9) Is Not a Susceptibility Factor for Osteoporosis in Europeans (2020) (2)
- Spätrekanalisation nach Vasoresektion (1991) (2)
- Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry (2019) (2)
- A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy (2022) (2)
- Mobility endpoints in marketing authorisation of drugs: what gets the European medicines agency moving? (2022) (2)
- C5 Variant rs10985126 is Associated with Mortality in Patients with Symptomatic Coronary Artery Disease (2021) (2)
- One non‐believer: Response to “Obviously Nine Believers: Actionable Germline Genetic Variants for Pre‐emptive Pharmacogenetic Testing” (2020) (1)
- Correction: Corrigendum: A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome (2015) (1)
- [Therapy of chronic inflammatory bowel diseases with azathioprine, 6-mercaptopurine and 6-thioguanine. Clinico-pharmacologic aspects]. (2003) (1)
- Thiopurines in the Treatment of Childhood Acute Lymphoblastic Leukemia and Genetic Variants of the Thiopurine S-Methyltransferase Gene (2008) (1)
- Relationship between Thiopurine metabolite levels and endoscopic improvement in patients with postoperative moderate to severe endoscopic recurrence of Crohn's disease (2010) (1)
- Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis (2021) (1)
- Neonatal morbidity and mortality associated with maternal haemolysis, elevated liver enzymes and low platelets syndrome the impact of neutropenia (1998) (1)
- [Pharmacogenetic diagnostics to improve drug therapy in clinical practice]. (2021) (1)
- CYP2D6 genotyping and tamoxifen in the treatment of post-menopausal breast cancer - a reply. (2014) (1)
- A call to caution when hydroxychloroquine is given to elderly patients with COVID-19 (2021) (1)
- Richtlinie: Labormedizinische Diagnostik bei der Therapie mit TPMT (Thiopurin-S-Methyltransferase)-abhängigen Pharmaka. Guidelines for the laboratory management of thiopurine drug therapy (2004) (1)
- Computational Treatment Simulations to Assess the Need for Personalized Tamoxifen Dosing in Breast Cancer Patients of Different Biogeographical Groups (2021) (1)
- Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1 (2013) (1)
- A Molecularly Characterized Preclinical Platform of Subcutaneous Renal Cell Carcinoma (RCC) Patient-Derived Xenograft Models to Evaluate Novel Treatment Strategies (2022) (1)
- The value of walking: a systematic review on mobility and healthcare costs (2022) (1)
- Bile acid monitoring to support safety and efficacy of Myrcludex B in combination with Tenofovir in patients with chronic HBV/HDV co-infection (2018) (1)
- Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3 (2019) (1)
- Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone (2022) (1)
- Abstract 257: Evaluation of organic cation transporter 1 (OCT1, SLC22A1) as transporter for sorafenib (2016) (1)
- CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth. (2019) (1)
- Assessing human urinary clomiphene metabolites after consumption of eggs from clomiphene-treated laying hens using chromatographic-mass spectrometric approaches. (2022) (1)
- 0064 CYP2D6 pharmacogenetics stratifies tamoxifen treatment outcome (2009) (1)
- Organic cation transporter pharmacogenomics and drug-drug (2010) (1)
- Metabolic Effect of Blocking Sodium-Taurocholate Co-Transporting Polypeptide in Hypercholesterolemic Humans with a Twelve-Week Course of Bulevirtide—An Exploratory Phase I Clinical Trial (2022) (1)
- Polymorphism with the Susceptibility to Renal (2002) (1)
- Pharmacokinetic differences between ethnic groups. Authors' reply (2002) (1)
- Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation (2022) (1)
- CD147, The Ancillary protein of MCT4, as marker for prognosis and clinical outcome in primary clear cell renal cell Carcinoma and Metastasis (2015) (1)
- [Rationale and methods of the UNAMET study (dose- and CYP2D6-genotype-dependent adverse drug reactions of metoprolol)--a contribution to quality improvement in pharmacotherapy]. (2004) (1)
- Characterization of Genetic Heterogeneity in Recurrent Metastases of Renal Cell Carcinoma (2021) (1)
- Looking back at genomic medicine in 2011 (2012) (1)
- Significant impact of time-of-day variation on metformin pharmacokinetics (2023) (1)
- ThioTEPA and Clopidogrel are specific mechanism-based inhibitors of human CYP2B6 (2002) (1)
- S1775 Development of a New Class of Thiopurine-Based Immunosuppressive Agents: Improved Ratio Between High Immunosuppressive Effects and Low Associated Toxicity (2010) (1)
- Determination of content uniformity of busulfan capsules by liquid chromatography–mass spectrometry (2012) (1)
- W1258 Relationship Between Thiopurine Metabolite Levels and Endoscopic Improvement in Patients With Postoperative Moderate to Severe Endoscopic Recurrence of Crohn's Disease (2010) (1)
- Targeted resequencing of 340 ADME genes in human liver with functional correlations (2017) (1)
- Association Between NOD2/CARD15 Gene Variants and Response to Antibiotics in Perianal Fistulizing Crohn's Disease (2006) (1)
- CYP2C19 Polymorphism and proton pump inhibitors (PPI) in Helicobacter Pylori eradication therapy–A Metaanalysis (2004) (1)
- Pharmacokinetic differences between ethnic groups (2002) (1)
- Impact of UGT1A4, UGT2B7, and UGT2B15 pharmacogenetics on tamoxifen (TAM) metabolism. (2013) (0)
- Antiarrhythmic drug treatment after cardioversion of atrial fibrillation (2012) (0)
- Abstract 1843: Intratumoral heterogeneity of renal cancer is related to differences in drug response and development of therapy resistance (2017) (0)
- Abstract 1632: Identification and analysis of EGLN3 as tumor-associated peptide in ccRCC (2017) (0)
- Synthesis of (Z) -Endoxifenhydrochlorid (2015) (0)
- A polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and CMF-based chemotherapy of patients with primary invasive breast cancer (2006) (0)
- Abstract 464: Gene expression signatures for the prediction of endocrine treatment outcome in early-stage luminal breast cancer patients (2019) (0)
- Psoriasis aggravation and metoprolol treatment -- a prospective observational case study. (2007) (0)
- ClinicallyRelevant OATP2B1 Inhibitors in MarketedDrug Space (2019) (0)
- CYP2D6: interethnic variability (2014) (0)
- Abstract 3485: Transcriptomic and metabolomic profiles in renal cell carcinoma (RCC) tumors reflect ontogeny of RCC subtypes (2018) (0)
- Evaluation of concomitant medication with non-anticancer drugs in patients with surgically treated clear cell renal cell carcinoma: Impact on prognosis, cell-cycle activity, and proliferation (2018) (0)
- 10. First PIPAC in-human application (2014) (0)
- Book Reviews · Bücher (2008) (0)
- Early Clinical Trials (2021) (0)
- Platelets and Polymorphisms (2017) (0)
- PD12-01 DOES CO-MEDICATION WITH NON-ANTICANCER DRUGS AFFECT OUTCOMES IN PATIENTS WITH SURGICALLY TREATED CLEAR CELL RENAL CELL CARCINOMA ? - EVALUATION OF SURVIVAL, CELL-CYCLE ACTIVITY, AND PROLIFERATION (2018) (0)
- 656 Efficacy of Tacrolimus in Ulcerative Colitis is Associated With Polymorphisms in the ABCB1 Gene (2010) (0)
- Performance comparison of narrow-bore and capillary liquid-chromatography for non-targeted metabolomics profiling by HILIC-QTOF-MS. (2023) (0)
- Intestinal Stem Cells in GI Physiology and Disease TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and-6 : implications for Crohn ’ s disease (2014) (0)
- 6-Thioguanine maintains remission in chronic active Crohn's disease (2003) (0)
- Open prospective study on 6-thioguanine (6-TG) for Crohn's disease (CD) intolerant or resistant to azathioprine (AZA) and/or 6-mercaptopurine (6-MP) (2003) (0)
- A Risk Factor for Accidental Drug Overdose (2017) (0)
- Variable Drug-Target Exposure, Tumor Signatures, and Combinatorial Targeted Treatment: Approaches of Personalized Medicine in Breast Cancer (2022) (0)
- Sa1781 Thiopurine Analogues for Optimized RAC1/Vav1 Blockade in Inflammatory Bowel Diseases (2013) (0)
- Syddansk Universitet Low heritability in pharmacokinetics of talinolol a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol , a putative probe drug of MDR 1 and other membrane transporters (2016) (0)
- [How to manage polypharmacia?] (2021) (0)
- Trade Name, INNs, and Medication Errors—Reply (2002) (0)
- Impact on clinical prognosis using DNA methylation of the SLC16A3 promoter and expression of the human lactate transporter MCT4 in renal cancer. (2014) (0)
- Abstract 5687: Integrative -omics analysis to identify drug targets for ccRCC immunotherapy (2018) (0)
- Author's response to reviews Title:The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARalpha-tr, autonomously regulates proliferative and pro-inflammatory genes Authors: (2015) (0)
- Specific therapeutic targeting of liver malignancies by transient depletion of adenosine tri-phosphates (2012) (0)
- Abstract 3351: Assessment of tamoxifen drug compliance by serum metabolite profiling in premenopausal breast cancer patients. (2013) (0)
- Kaplan-Meier analysis for incidence of MACE according PREDICT-STABLE Score (comparison of score levels 0–3 with 7–9). (2015) (0)
- P126 Alteration of Thiopurinephosphate Metabolite Levels by 5-Aminosalicylates in Thiopurine Using IBD-Patients (2008) (0)
- Impact of genotypic differences in CYP2C19 status on the eradication of Helicobacter pylori in Caucasian patients (2003) (0)
- Thiopurine Methyltransferase Genetics Is Associated with Treatment Outcome and Hepatic Toxicity in Pediatric Patients with Acute Lymphoblastic Leukemia: a Report From the ALL-BFM Study Group. (2009) (0)
- Abstract P2-11-12: The influences of adherence to tamoxifen and CYP2D6 pharmacogenetics on plasma concentrations of the active metabolite (Z)-endoxifen in breast cancer (2020) (0)
- Editorial. (2021) (0)
- Pharmacogenomics of Inflammatory Bowel Diseases (2012) (0)
- Influence of CYP2C9 amino acid polymorphisms on enantioselective metabolism of R‐,S‐phenprocoumon (2003) (0)
- Specific therapeutic targeting of malignancies of the liver by transient depletion of adenosine triphosphates (2011) (0)
- Abstract 2529: Comprehensive genomic analyses of a case series of bilateral renal cell carcinoma (2019) (0)
- Nutzen der zweiten Generation der Kolon-Kapsel zur Detektion kolorektaler Polypen - systematischer Review und Meta-Analyse (2020) (0)
- Haftung bei verbundenen Non-Profit-Vereinen (2013) (0)
- Perfusion Air Culture of Precision-Cut Tumor Slices: An Ex Vivo System to Evaluate Individual Drug Response under Controlled Culture Conditions (2023) (0)
- 96 The Wnt Co-Receptor LRP6 as a New Factor in Ileal Crohn's Disease (2012) (0)
- Personalising drug safety—results from the multi-centre prospective observational study on Adverse Drug Reactions in Emergency Departments (ADRED) (2019) (0)
- Drug Use, Dosing, and Toxicity in Renal Disease (2016) (0)
- Population Pharmacokinetics As A Tool To Re-Evaluate The Complex Disposition of Ethanol In The Fed And Fasted State. (2023) (0)
- The role of the breast cancer resistance protein (BCRP/ABCG2) in clear cell renal cell carcinoma - a characterization study (2018) (0)
- FUNCTIONAL SIGNIFICANCE OF GENETIC POLYMORPHISMS OF HUMAN CYP2B6 (2002) (0)
- Abstract 1693: Nicotinamide N-methyltransferase in clear cell renal cell carcinoma primary tumors and metastases (2016) (0)
- Physiologically Based Pharmacokinetic Modeling of Tacrolimus for Food-Drug and CYP3A Drug-Drug-Gene Interaction Predictions. (2023) (0)
- CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL (2022) (0)
- Molecular-epidemiological aspects of carcinogenesis : the role of xenobiotic metabolizing enzymes * (2002) (0)
- Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy (2020) (0)
- Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms (2014) (0)
- Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group (2023) (0)
- From Unit to Dose: A Machine Learning Approach for Precise Prediction of Hemoglobin and Iron Content in Individual Packed Red Blood Cell Units (2022) (0)
- Cohort profile: Greifswald approach to individualized medicine (GANI_MED) (2014) (0)
- Pharmacological targeting of ACKR3/CXCR7 enhances anticoagulant acylcarnitine levels in platelets and modulates thrombotic response to lipids (2023) (0)
- Untargeted stable isotope-resolved metabolomics to assess the effect of PI3Kβ inhibition on metabolic pathway activities in a PTEN null breast cancer cell line (2022) (0)
- The Authors′ Reply (2007) (0)
- From genomic medicine to precision medicine: highlights of 2015 (2016) (0)
- Original Article Gastrointestinal stromal tumors of the esophagus: evaluation of a pooled case series regarding clinicopathological features and clinical outcome (2015) (0)
- 343P DPYD gene sequencing and in silico functionality prediction of polymorphisms in 3,471 colorectal cancer patients treated with fluoropyrimidine (FP) (2022) (0)
- Translational learning from clinical studies predicts drug pharmacokinetics across patient populations (2017) (0)
- Safety and efficacy of 6-thioguanine (6-TG) in patients with ulcerative and indeterminate colitis intolerant or resistant to azathioprine and/or 6-mercaptopurine (Aza/6-MP) (2003) (0)
- Thioredoxin 1 (Trx1) is associated with poor prognosis in clear cell renal cell carcinoma (ccRCC): an example for the crucial role of redox signaling in ccRCC (2021) (0)
- Precision Management of a Patient With Dihydropyrimidine Dehydrogenase Deficiency and Liver-Predominant Metastatic Rectal Cancer Using Hepatic Arterial Floxuridine. (2023) (0)
- Corrigendum to: Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients. (2020) (0)
- Study protocol of the RaPS study: novel risk adapted prevention strategies for people with a family history of colorectal cancer (2018) (0)
- Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression (2019) (0)
- Pharmacogenomics in pediatric medicine and drug development. (2022) (0)
- Genetic variation in human drug-related genes (2017) (0)
- Genetic Biomarkers in Epilepsy (2014) (0)
- Mo1714 Designer Thiopurine Analogues for Optimized Immunosuppressive Therapy of Inflammatory Bowel Disease (2014) (0)
- Genetic variation in human drug-related genes you. (2017) (0)
- Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine (2016) (0)
- 2012 highlights in translational 'omics (2013) (0)
- A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug–Drug Interaction Perpetrators (2023) (0)
- Dendritic Cells or Macrophages? The Microenvironment of Human Clear Cell Renal Cell Carcinoma Imprints a Mosaic Myeloid Subtype Associated with Patient Survival (2022) (0)
- Alterstraumatologie I Proximaler Femur I (2000) (0)
- Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters (2016) (0)
- Abstract 5219: Characterization of the breast cancer resistance protein BCRP in clear cell renal cell carcinoma (2017) (0)
- Differential effects of metformin on breast cancer proliferation according to insulin resistance and tumor subtype in a presurgical trial. (2014) (0)
- [Medical history taking via computer can provide better care and research]. (2014) (0)
- ' s response to reviews Title : Prediction of breast cancer by profiling of urinary RNA metabolites using SVM-based feature selection (2009) (0)
- Cross‐Ancestry Genome‐Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations (2023) (0)
- Prediction of Drug–Drug–Gene Interaction Scenarios of (E)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling (2022) (0)
- Ten years of Genome Medicine (2019) (0)
- Functional genomics suggest neurogenesis in the adult human olfactory bulb (2013) (0)
- The Role of Mobility Endpoints in Marketing Authorisation of Drugs: What Gets the EMA Moving? (2021) (0)
- Pharmacogenomics: a key component of personalized therapy (2012) (0)
- 13. Anticancer Drugs (2012) (0)
- Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles (2018) (0)
- P3643Junctional Adhesion Molecule-A (JAM-A) polymorphisms influence serum levels of soluble JAM-A and are associated with long term prognosis in coronary artery disease (2019) (0)
- Abstract 44: An in vivo platform of pre-characterized renal cell carcinoma (RCC) patient-derived xenograft models allows the preclinical evaluation of patient-tailored intervention strategies (2023) (0)
- Adme-wide analysis of Copy Number Variation using Targeted exome resequencing and their functional relevance in Human Liver (2015) (0)
- Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor (2017) (0)
- Cancer Therapy : Preclinical Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 ( OCT 1 ) (2014) (0)
- ABCB1 genetics predicts tacrolimus response in patients with ulcerative colitis. Running head: Tacrolimus Pharmacogenetics in IBD (2010) (0)
- Abstract 3425: Exome-sequencing derived mutations of endocrine treated ER-positive early breast cancer (2018) (0)
- Transcriptomic and metabolomic profiling in kidney tissue – a combined approach (2018) (0)
- No association of genetic variants in TLR4, TNF-α, IL10, IFN-γ, and IL37 in cytomegalovirus-positive renal allograft recipients with active CMV infection—Subanalysis of the prospective randomised VIPP study (2021) (0)
- ScienceDirect - Journal of Chromatography B, Volume 831, Issues 1-2, Pages 1-346 (2 February 2006) (2006) (0)
- University of Southern Denmark Site-specific absence of microfibrillar-associated protein 4 (MFAP4) from the internal elastic membrane of arterioles in the rheumatoid arthritis synovial membrane an immunohistochemical study in patients with advanced rheumatoid arthritis versus osteoarthritis (2019) (0)
- Abstract 2029: A high ratio of tamoxifen metabolite E to tamoxifen is associated with an increased risk of breast cancer recurrences in premenopausal women (2016) (0)
- Individual pharmacokinetics play a major role in toxicity of the BEACOPP polychemotherapy regimen in Hodgin's disease (2005) (0)
- Pharmacogenomics in personalized laboratory medicine , a new opportunity for more effective and safer treatment (2014) (0)
- Endocrine Therapy: Translational Research on CYP2D6 Genetics for Tamoxifen Response in Breast Cancer (2008) (0)
- Personalized laboratory medicine: Results of an european survey conducted by the EFLM/ESPT WG-PLM (2015) (0)
- P124 - Efficacy and toxicity of tacrolimus in steroid resistant ulcerative colitis cannot be predicted by genetic polymorphisms of the CYP3A4, CYP3A5, ABCB1 and NR1I2 genes (2009) (0)
- Supplemental Table 1 primers (2013) (0)
- Erratum: Data collection as a barrier to personalized medicine: [Trends in Pharmacological Sciences 36 (2015), 68–71] (2015) (0)
- Supplemental Table 2 (2013) (0)
- Pharmacogenetics of inflammatory bowel disease therapy (2005) (0)
- Sex Is a Major Determinant in Human of CYP3A4 liver Expression (2005) (0)
- Cell selection process and derived cells (2012) (0)
- Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST) (2015) (0)
- Abstract 5033: Optimized CYP2D6 phenotype assignment for plasma endoxifen prediction in breast cancer patients treated with tamoxifen (2017) (0)
- Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver (2019) (0)
- Pharmacodynamics Methyltransferase on Mercaptopurine and Thioguanine Differential Effects of Targeted Disruption of Thiopurine (2007) (0)
- Pharmakogenomik: Hype oder Hope? (2011) (0)
- Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers (2023) (0)
- Kaplan-Meier analysis for incidence of MACE according platelet function analysis (comparison of HPR vs. adequate on-treatment response in Patients with high PREDICT-STABLE Score 7–9). (2015) (0)
- P3641Matrix Metalloproteinase-2 polymorphisms are associated with prognosis of patients with symptomatic coronary artery disease (2019) (0)
- Pruritus and Anemia in a Patient on Peritoneal Dialysis — Pitfalls in Diagnosis for Common Symptoms (2000) (0)
- Abstract 2747: PARP inhibitors act synergistically with cisplatin and doxorubicin in BRCA competent cells by compromising chemotherapy-induced replication arrest (2016) (0)
- Abstract P3-10-07: T5 Is a New Molecular Predictor of Distant Recurrence in Estrogen Receptor-Positive, HER2-Negative Breast Cancer (2010) (0)
- Title: Obesity alters endoxifen plasma levels in young breast cancer patients: A pharmacometric simulation approach. Authors: (2020) (0)
- Reduced Paneth cell a-defensins in heal Crohn's disease (2005) (0)
- Rehabilitation nach Trauma (1999) (0)
- Running Title Page Running Title : Expression of drug uptake and efflux transporters in HCC (2014) (0)
- Trade name, INNs, and mediation errors. Author's reply (2002) (0)
- The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes (2017) (0)
- MP58-03 IDENTIFICATION OF SPECIFIC METHYLATION-BASED BIOMARKERS FOR THE ASSESSMENT OF THE METASTATIC RISK OF MUSCLE INVASIVE BLADDER CANCER (2015) (0)
- Myocardial extracellular volume fraction (ECV) measurements based on T1-mapping in healthy monozygotic twins - another similarity or rather disagreement in twins? (2015) (0)
- Su1204 Association Between Eleven Thiopurine Metabolites and Mucosal Healing in Patients With Crohn's Disease (2015) (0)
- Targeted Exome Resequencing: Adme Pharmacogenetics In Human Liver (2015) (0)
- Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease (2018) (0)
- Utility value of the S3-score in metastatic and non-metastatic clear cell renal cell carcinoma for a molecular prediction of clinical outcome (2018) (0)
- Pharmacogenomics of adme and personalized medicine – Where do we stand? (2017) (0)
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