Mavis Agbandje-McKenna
Biochemist and researcher
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Biology
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(Suggest an Edit or Addition)According to Wikipedia, Mavis Agbandje-McKenna was a Nigerian-born British medical biophysicist, structural virologist, and a professor of structural biology, as well as the director of the Center for Structural Biology at the University of Florida in Gainesville, Florida. Agbandje-McKenna studied parvovirus structures using X-ray crystallography and cryogenic electron microscopy and did much of the initial work to elucidate the basic structure and function of adeno-associated viruses . Her viral characterization and elucidation of antibody binding sites on AAV capsids has led to the development of viral capsid development and gene therapy approaches that evade immune detection and can be used to treat human diseases such as muscular dystrophies. Agbandje-McKenna was recognized with the 2020 American Society of Gene and Cell Therapy Outstanding Achievement Award for her contributions to the field. She died in 2021 from amyotrophic lateral sclerosis .
Mavis Agbandje-McKenna's Published Works
Published Works
- The three-dimensional structure of canine parvovirus and its functional implications. (1991) (484)
- Structure determination of feline panleukopenia virus empty particles (1993) (181)
- The structure of human parvovirus B19 at 8 A resolution. (1994) (121)
- Characterization of the feline host range and a specific epitope of feline panleukopenia virus. (1994) (73)
- Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives. (1992) (69)
- The structure of parvoviruses (1995) (51)
- Structure determination of monoclinic canine parvovirus. (1992) (27)
- Anthracene-9,10-diones as potential anticancer agents: bacterial mutation studies of amido-substituted derivatives reveal an unexpected lack of mutagenicity. (1998) (27)
- Preliminary X-ray crystallographic investigation of human parvovirus B19. (1991) (22)
- The recognition of parvovirus capsids by antibodies (1995) (13)
- Experimental DNA-binding and computer modelling studies on an analogue of the anti-tumor drug amsacrine. (1988) (12)
- Anthracene‐9,10‐diones as Potential Anticancer Agents. Synthesis, DNA‐ Binding, and Biological Studies on a Series of 2,6‐Disubstituted Derivatives. (1993) (2)
- Structure and conformational features of 9‐(4‐diethylaminophenyl)acridine (1990) (1)
- Structure of 9‐amino‐2,7‐di‐tert‐butylacridine (1992) (1)
- M-PMA 5 FTIR SPECTROSCOPY OF TIE HISMZS-_ LEU HETERODIMER MUTANT OF RB . CAPSULATUS . (2005) (0)
- The structure of canine parvo-virus (1993) (0)
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