Max Birnstiel
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Swiss molecular biologist
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Max Birnstielbiology Degrees
Biology
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Molecular Biology
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Biology
Max Birnstiel's Degrees
- PhD Biochemistry University of Zurich
Why Is Max Birnstiel Influential?
(Suggest an Edit or Addition)According to Wikipedia, Max Luciano Birnstiel was a Swiss molecular biologist who held a number of positions in scientific leadership in Europe, including the chair of the Institute of Molecular Biology at the University of Zurich from 1972–86, and that of founding director of the Research Institute of Molecular Pathology in Vienna from 1986 to 1996. His research focused on gene regulation in eukaryotes. His research group is sometimes cited as the first to purify single genes, the ribosomal RNA genes from Xenopus laevis, three years before the successful isolation of the lac operon. He is also recognized for one of the earliest discoveries of a gene enhancer element. Birnstiel died in 2014 of heart failure during cancer treatment.
Max Birnstiel's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Transcription termination and 3′ processing: the end is in site! (1985) (1075)
- A simple method for DNA restriction site mapping. (1976) (727)
- Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle. (1992) (664)
- Transferrin-polycation conjugates as carriers for DNA uptake into cells. (1990) (627)
- Structure and Function of Major and Minor Small Nuclear Ribonucleoprotein Particles (1988) (566)
- Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. (1992) (483)
- Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. (1991) (456)
- The organization and expression of histone gene families (1981) (381)
- Ribosomal cistrons and the nucleolar organizer. (1966) (360)
- Kinetic complexity of RNA molecules. (1972) (347)
- Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements (1981) (339)
- Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. (1990) (320)
- High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. (1992) (315)
- Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo. (1980) (275)
- Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells. (1990) (262)
- Properties and Composition of the Isolated Ribosomal DNA Satellite of Xenopus laevis (1968) (245)
- Reiteration and clustering of DNA sequences complementary to histone messenger RNA. (1971) (226)
- The ribosomal RNA cistrons. (1971) (218)
- High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes. (1992) (215)
- Mature mRNA 3′ end formation stimulates RNA export from the nucleus. (1991) (209)
- Ribozyme mediated destruction of RNA in vivo. (1989) (183)
- Spacer DNA sequences upstream of the T-A-T-A-A-A-T-A sequence are essential for promotion of H2A histone gene transcription in vivo. (1980) (174)
- Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing (1978) (169)
- Sequence organization of the spacer DNA in a ribosomal gene unit of Xenopus laevis (1979) (163)
- STUDIES ON PHYTOFERRITIN. I. IDENTIFICATION AND LOCALIZATION. (1963) (157)
- Cancer vaccines: the interleukin 2 dosage effect. (1995) (145)
- Properties of the ribosomal RNA precursor in Xenopus laevis; comparison to the precursor in mammals and in plants. (1969) (140)
- A split promoter for a eucaryotic tRNA gene (1981) (133)
- DNA-binding transferrin conjugates as functional gene-delivery agents: synthesis by linkage of polylysine or ethidium homodimer to the transferrin carbohydrate moiety. (1991) (132)
- Immunotherapy of metastatic malignant melanoma by a vaccine consisting of autologous interleukin 2-transfected cancer cells: outcome of a phase I study. (1999) (129)
- The cDNA sequences of the sea urchin U7 small nuclear RNA suggest specific contacts between histone mRNA precursor and U7 RNA during RNA processing. (1984) (124)
- Receptor-mediated transport of DNA into eukaryotic cells. (1993) (122)
- THE NUCLEOLUS, A SOURCE OF RIBOSOMES. (1963) (120)
- Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex. (1995) (116)
- Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3′ end of H3 messenger RNA (1986) (115)
- Sea urchin histone mRNA termini are located in gene regions downstream from putative regulatory sequences (1980) (112)
- Molecular analysis of the histone gene cluster of Psammechinus miliaris: II. The arrangement of the five histone-coding and spacer sequences (1976) (109)
- Generation of histone mRNA 3′ ends by endonucleolytic cleavage of the pre‐mRNA in a snRNP‐dependent in vitro reaction. (1986) (108)
- Priming of tumor-specific T cells in the draining lymph nodes after immunization with interleukin 2-secreting tumor cells: three consecutive stages may be required for successful tumor vaccination. (1995) (107)
- Expression of sea urchin histone genes in the oocyte of Xenopus laevis. (1979) (105)
- The artificial antimicrobial peptide KLKLLLLLKLK induces predominantly a TH2-type immune response to co-injected antigens. (2004) (98)
- Chicken adenovirus (CELO virus) particles augment receptor-mediated DNA delivery to mammalian cells and yield exceptional levels of stable transformants (1993) (97)
- 3' editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors. (1984) (96)
- NK-kappa B subunit-specific regulation of the I kappa B alpha promoter. (1994) (95)
- The terminal RNA stem-loop structure and 80 bp of spacer DNA are required for the formation of 3′ termini of sea urchin H2A mRNA (1983) (94)
- Ubiquitous and gene-specific regulatory 5' sequences in a sea urchin histone DNA clone coding for histone protein variants. (1980) (93)
- Generation of authentic 3′ termini of an H2A mRNA in vivo is dependent on a short inverted DNA repeat and on spacer sequences (1982) (90)
- Location of the genes for 5S ribosomal RNA in Xenopus laevis (2004) (90)
- Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid. (1994) (87)
- Structure and expression in L-cells of a cloned H4 histone gene of the mouse. (1981) (85)
- Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3′ RNA processing reaction. (1988) (82)
- PROTEIN SYNTHESIS BY ISOLATED PEA NUCLEOLI (1963) (82)
- Localization of amplified ribosomal DNA in the oocyte of Xenopus laevis. (1968) (81)
- Kinetic complexity of chloroplastal deoxyribonucleic acid and mitochondrial deoxyribonucleic acid from higher plants. (1969) (79)
- More ribosomal spacer sequences from Xenopus laevis. (1980) (79)
- The replication of purified DNA introduced into living egg cytoplasm. (1969) (78)
- In vivo production of human factor VII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery. (1994) (76)
- Transferrinfection: A Highly Efficient Way to Express Gene Constructs in Eukaryotic Cells (1992) (76)
- Reiterated transfer RNA genes of Xenopus laevis. (1973) (75)
- Genetic complementation in the Xenopus oocyte: co‐expression of sea urchin histone and U7 RNAs restores 3′ processing of H3 pre‐mRNA in the oocyte. (1986) (72)
- Heat-labile regulatory factor is required for 3' processing of histone precursor mRNAs. (1987) (70)
- Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway. (1992) (67)
- The conserved CAAGAAAGA spacer sequence is an essential element for the formation of 3′ termini of the sea urchin H3 histone mRNA by RNA processing. (1985) (65)
- Molecular analysis of the histone gene cluster of Psammechinus miliaris: I. Fractionation and identification of five individual histone mRNAs (1976) (63)
- ON THE NATURE OF NUCLEOLAR RNA. (1963) (63)
- Localization of sequences coding for histone messenger RNA in the chromosomes of Drosophila melanogaster (1977) (62)
- Delimitation of far upstream sequences required for maximal in vitro transcription of an H2A histone gene. (1982) (61)
- Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro (1989) (60)
- An unusual evolutionary behaviour of a sea urchin histone gene cluster (1982) (60)
- Transcription of xenopus tDNAmet1 and sea urchin histone DNA injected into the Xenopus oocyte nucleus. (1978) (60)
- Transcription of cloned tRNA gene fragments and subfragments injected into the oocyte nucleus of Xenopus laevis. (1978) (60)
- The putative promoter of a Xenopus laevis ribosomal gene is reduplicated. (1979) (60)
- Processing and nucleo-cytoplasmic transport of histone gene transcripts. (1984) (60)
- Molecular hybridization of 3H-labelled ribosomal RNA with DNA in ultrathin sections prepared for electron microscopy. (1971) (59)
- Cell-free tumor antigen peptide-based cancer vaccines. (1997) (59)
- Nucleolus: A Center of RNA Methylation (1963) (59)
- Conserved terminal hairpin sequences of histone mRNA precursors are not involved in duplex formation with the U7 RNA but act as a target site for a distinct processing factor. (1989) (58)
- Arrangement of the 5-8 S RNA cistrons in the genome of Xenopus laevis. (1974) (58)
- Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif. (1989) (58)
- Clustering of transfer RNA genes of Xenopus laevis. (1973) (57)
- Two-step affinity purification of U7 small nuclear ribonucleoprotein particles using complementary biotinylated 2'-O-methyl oligoribonucleotides. (1991) (56)
- Delimitation of a promoter for RNA polymerase III by means of a functional test. (1979) (55)
- Transloading of tumor antigen-derived peptides into antigen-presenting cells. (1997) (55)
- A tRNA gene of Xenopus laevis contains at least two sites promoting transcription. (1979) (54)
- Partial denaturation mapping of cloned histone DNA from the sea urchin Psammechinus miliaris (1976) (53)
- Molecular analysis of the histone gene cluster of Psammechinus miliaris: III. Polarity and asymmetry of the histone-coding sequences (1976) (52)
- Major changes in the 5′ and 3′ chromatin structure of sea urchin histone genes accompany their activation and inactivation in development (1983) (52)
- Structure and Function of Minor snRNPs (1988) (52)
- Amplication of ribosomal cistrons in the heterochromatin of acheta. (1969) (51)
- 2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event. (1991) (51)
- The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins (1997) (50)
- Isolation and some properties of the genes coding for histone proteins. (1974) (46)
- Vaccination with poly-L-arginine as immunostimulant for peptide vaccines: induction of potent and long-lasting T-cell responses against cancer antigens. (2002) (46)
- ON THE CHEMISTRY AND ORGANISATION OF NUCLEOLAR PROTEINS. (1964) (44)
- Bioassay for components regulating eukaryotic gene expression: a chromosomal factor involved in the generation of histone mRNA 3' termini. (1982) (44)
- Somatic gene therapy for cancer: the utility of transferrinfection in generating 'tumor vaccines'. (1993) (43)
- Intranuclear Site of Histone Synthesis (1964) (41)
- Integration of eukaryotic genes for 5S RNA and histone proteins into a phage lambda receptor. (1976) (41)
- Mapping of the Xenopus laevis 5.8S rDNA by restriction and DNA sequencing. (1978) (40)
- Surrogate Genetics in the Frog Oocyte (1980) (40)
- Family of Ribosomal Genes of Xenopus laevis (1969) (38)
- Observations on fine structure in pea nucleoli in situ and isolated. (1965) (38)
- Carbohydrate receptor-mediated gene transfer to human T leukaemic cells. (1994) (38)
- Integrity of the DNA template, a prerequisite for the faithful transcription of Xenopus rDNA in vitro. (1972) (38)
- Point mutation in the TATA box curtails expression of sea urchin H2A histone gene in vivo (1981) (36)
- Reiteration frequency of the histone genes in the genome of the amphibian, Xenopus laevis. (1976) (36)
- Functional analysis of the sea urchin U7 small nuclear RNA (1988) (35)
- Biochemical and ultrastructural characteristics of ribonucleoprotein particles isolated from rat-liver cell nucleoli. (1969) (34)
- Nucleosome arrangement on tRNA genes of Xenopus laevis (1981) (33)
- Developmental regulation of micro-injected histone genes in sea urchin embryos. (1988) (33)
- Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene. (1996) (33)
- Transcription of a cloned Xenopus laevis H4 histone gene in the homologous frog oocyte system depends on an evolutionary conserved sequence motif in the -50 region. (1983) (33)
- Incorporation of l-[14C]leucine by isolated nuclei (1962) (32)
- THE NUCLEAR SYNTHESIS OF RIBOSOMES IN CELL CULTURES. (1964) (32)
- PROTEIN SYNTHESIS BY ISOLATED NUCLEI FROM EXPONENTIALLY DIVIDING CELLS. (1963) (30)
- Transcriptional fidelity of histone genes injected into Xenopus oocyte nuclei (1980) (29)
- Novel screening procedure for recombinant plasmids. (1977) (28)
- INHIBITION OF DNA REPLICATION AND ITS EFFECT ON HISTONE SYNTHESIS. (1964) (27)
- Reiteration frequency of histone coding sequences in man. (1974) (27)
- DNA sequences coding for the H2B histone of Psammechinus miliaris (1977) (27)
- Cell cycle-dependent regulation of histone precursor mRNA processing by modulation of U7 snRNA accessibility (1990) (25)
- Incorporation of leucine-H3 into subnuclear components of isolated pea nuclei. (1961) (25)
- Dangerous liaisons: Spermatozoa as natural vectors for foreign DNA? (1989) (24)
- Analysis of a sea urchin gene cluster coding for the small nuclear U7 RNA, a rare RNA species implicated in the 3' editing of histone precursor mRNAs. (1986) (24)
- Is gene amplification RNA-directed? (1973) (23)
- Stimulation of sea urchin H2B histone gene transcription by a chromatin-associated protein fraction depends on gene sequences downstream of the transcription start site (1985) (23)
- Fractionation of isolated pea nuclei (1962) (22)
- Detection of labelled RNA species by contact hybridization. (1979) (21)
- A functional component of the sea urchin H2A gene modulator contains an extended sequence homology to a viral enhancer. (1983) (20)
- Transloading of tumor cells with foreign major histocompatibility complex class I peptide ligand: a novel general strategy for the generation of potent cancer vaccines. (1996) (19)
- SYNTHESIS OF TRANSFER RNA BY ISOLATED NUCLEI. (1963) (19)
- Histone mRNA in Xenopus laevis ovaries: identification of the H4 messenger. (1977) (19)
- Histone genes from Xenopus laevis: molecular cloning and initial characterization. (1980) (18)
- High-efficiency gene transfer by adenovirus coupled to DNA-polylysine complexes (1992) (17)
- Generation of effective cancer vaccines genetically engineered to secrete cytokines using adenovirus-enhanced transferrinfection (AVET). (1997) (16)
- Clustered arrangement of tRNA genes of Xenopus laevis. (1974) (16)
- Depletion of naive T cells of the peripheral lymph nodes abrogates systemic antitumor protection conferred by IL-2 secreting cancer vaccines. (1996) (15)
- Current work on the histone operon (1977) (15)
- The arrangement of 18-S and 28-S ribosomal ribonucleic acids within the 40-S precursor molecule of Xenopus laevis. (1976) (15)
- Some bacterial tRNA genes are transcribed by eukaryotic RNA polymerase III. (1982) (15)
- Analysis of histone messenger RNA of Drosophila melanogaster by two-dimensional gel electrophoresis. (1978) (14)
- ISOPYCNIC CENTRIFUGATION OF DNA METHODS AND APPLICATIONS (1972) (14)
- Regulation of histone gene expression. (1985) (13)
- Evolutionary conserved multiprotein complexes interact with the 3' untranslated region of histone transcripts. (1992) (12)
- Analysis of a gene cluster coding for the Xenopus laevis U7 snRNA. (1992) (11)
- Rhynchosciara angelae salivary gland DNA: kinetic complexity and transcription of repetitive sequences. (1973) (10)
- [55] 5′ labeling and poly(A) tailing (1980) (10)
- Nucleic Acid Hybridization in the Study of Cell Differentiation (1972) (10)
- The relationship between protein synthesis and ribosomal DNA amplification in Xenopus laevis. (1971) (10)
- Evolution of 9S mRNA Sequences (1973) (9)
- Tumor vaccines: effects and fate of IL-2 transfected murine melanoma cells in vivo. (1995) (9)
- FURTHER OBSERVATIONS CONCERNING SYNTHETIC SYSTEMS WITH PEA RIBOSOMES. (1963) (8)
- Histones in the Wild-Type and the Anucleolate Mutant of Xenopus laevis (1967) (7)
- The modulator is a constitutive enhancer of a developmentally regulated sea urchin histone H2A gene. (2002) (7)
- Kinetic analysis of the base sequence heterogeneity of RNA molecules by RNA-DNA hybridization. (1972) (6)
- Aspects of the regulation of histone genes. (1978) (5)
- 5'-Labeling and poly(dA) tailing. (1980) (5)
- A timing study of DNA amplification in Xenopus laevis oocytes (2004) (3)
- Histone H4 mRNA levels are down-regulated by 3' RNA processing during terminal differentiation of myoblasts. (1992) (3)
- Adenovirus-enhanced receptor-mediated transferrinfection for the generation of tumor vaccines. (1996) (2)
- Receptor-mediated gene delivery into mammalian cells (1994) (2)
- The dawn of gene isolation. (2002) (2)
- The inability of the Psammechinus miliaris H3 RNA to be processed in the Xenopus oocyte is associated with sequences distinct from those highly conserved amongst sea urchin histone RNAs. (1987) (2)
- Amphibian oocytes and sphere organelles: are the U snRNA genes amplified? (1992) (1)
- Synthetic virus-like gene delivery systems (1994) (1)
- Cancer vaccines : The interleukin 2 dosage effect ( granulocyte-macrophage colony-stimulating factor / tumor vaccine / murine melanoma ) (1)
- Further liaisons with sperm. (1989) (1)
- Receptor-mediated endocytosis of transferrin-polycation conjugates : An efficient way to introduce DNA into hematopoietic cells ( transferrinfection / transferrin receptor / chloroquine / DNA transfection / gene therapy ) (1)
- HISTONES AND THEIR REGULATION (1981) (1)
- Vaccine formulation comprising sugar-alcohols and low concentrations of anorganic ions (1999) (0)
- FUNCTIONAL ELEMENTS OF SEA URCHIN HISTONE GENES (1980) (0)
- The genetic revolution 1950–1996: an introduction (1996) (0)
- A pharmaceutical composition for immunostimulation and for preparation of vaccines containing an antigen, and an immunogenic oligodeoxynucleotide as adjuvants and a polycationic polypeptide (2001) (0)
- New protein-polykationkonjugater (1991) (0)
- DNA molecule and its use (1990) (0)
- In vitro evaluation of a tumor vaccine based on the xenogenization of tumor cells with tetanus toxoid molecules (1999) (0)
- THE GENERATION OF TUMOR VACCINES BY ADENOVIRUS ENHANCED TRANSFERRINFECTION OF CYTOKINE GENES INTO TUMOR CELLS (1994) (0)
- pharmaceutical composition for peptide-based immune modulation and processing aids. (1997) (0)
- Transferrin-polycation-DNA complexes: Theeffect ofpolycations onthestructure ofthecomplex andDNA delivery tocells (1991) (0)
- Tumor vaccines and methods for their preparation (1995) (0)
- Somatic gene therapy of cancer (2007) (0)
- New conjugates of introducing nucleic acids into higher eukaryotic cells (1994) (0)
- Some Experiments Relating to the Homogeneity and Arrangement of the Ribosomal RNA Genes of Xenopus laevis (2008) (0)
- Gene isolation is 25 years old this month. (1990) (0)
- 3′ Processing of histone RNA precursors (2004) (0)
- Gene therapy (1996) (0)
- The Genetical Society of Great Britain Abstracts of Papers read at the hundred and fifty-ninth meeting of the Society held on 26th, 27th and 28th March 1969 at Edinburgh University. (1969) (0)
- A pharmaceutical composition for immune modulation, which are based on peptides and adjuvants (1997) (0)
- A pharmaceutical composition for immunomodulation based on peptides and adjuvants (1997) (0)
- Processing and nudeo-cytophlsmic trnusport of histone gene tnnscripts (0)
- Sea urchin histone genes: the beginning and end of the message. (1984) (0)
- A process for the preparation of cancer vaccines (1995) (0)
- Functional Analysis oftheSeaUrchin U7Small Nuclear RNA (1988) (0)
- (histone genes/RNA processing/palindrome/small nuclear ribonucleo (2016) (0)
- stable transformants. mammalian cells and yield exceptional levels of augment receptor-mediated DNA delivery to Chicken adenovirus (CELO virus) particles (2013) (0)
- Receptor-mediated endocytosis of transferrin-polycation (0)
- Anti-tumor effector mechanisms generated by vaccination with interleukin-2 transfected murine melanoma cells (1994) (0)
- Regulated 3′ processing of histone mRNA requires both the U7 snRNP and a heat-labile component with interesting properties (1987) (0)
- Erratum to “The dawn of gene isolation” [Gene 300 (2003) 3–11] (2004) (0)
- Developmental control of histone gene expression. (1982) (0)
- Interleukin-2 transfected melanoma cells for tumor vaccination. — From animal models to clinical trials — (1995) (0)
- Isolation and Some Properties of the Genes Coding for Histone Proteins ( histone genes / spacer DNA / synonymous codons / evolution ) (0)
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