Meenhard Herlyn
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Cancer researcher
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Meenhard Herlyn's Degrees
- Doctorate Medicine University of Hamburg
- PhD Immunology University of Hamburg
Why Is Meenhard Herlyn Influential?
(Suggest an Edit or Addition)According to Wikipedia, Meenhard Herlyn, D.V.M., D.Sc., is a researcher who works as director of The Wistar Institute Melanoma Research in Philadelphia. Herlyn obtained his D.V.M. degree from the University of Veterinary Medicine, Hanover, in 1970. Following that, in 1976, he earned a D.Sc. in medical microbiology from the University of Munich. In 1976, he joined The Wistar Institute as an associate scientist, focusing on the emerging field of monoclonal antibodies—a groundbreaking technology that now underlies a significant portion of targeted therapeutics. Transitioning to the role of assistant professor in 1981, Herlyn established a renowned laboratory dedicated to studying melanoma biology, which remains highly regarded in the field to this day. His primary research focus is the underlying biology behind melanoma, the most aggressive form of skin cancer. Over the course of his career, he has been responsible for the use of three-dimensional artificial skin cultures to study tumor and normal cells, a clearer understanding of stem cells and how they relate to cancer, and signaling pathways related to cancer. The Wistar Melanoma cell lines that Herlyn has used and helped discover in his laboratory are responsible for a better understanding of the major steps of tumor progression in human cases of melanoma.
Meenhard Herlyn's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions (2005) (2063)
- A promoter-level mammalian expression atlas (2014) (1664)
- Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response (2018) (1427)
- A tumorigenic subpopulation with stem cell properties in melanomas. (2005) (1294)
- Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity (2008) (1267)
- Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. (2010) (1228)
- BRAF and RAS mutations in human lung cancer and melanoma. (2002) (1106)
- A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth (2010) (1091)
- High-throughput oncogene mutation profiling in human cancer (2007) (1041)
- Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance (2017) (770)
- Axis of evil: molecular mechanisms of cancer metastasis (2003) (604)
- Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. (2013) (528)
- Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. (2006) (523)
- Regulation of Notch1 and Dll4 by Vascular Endothelial Growth Factor in Arterial Endothelial Cells: Implications for Modulating Arteriogenesis and Angiogenesis (2003) (515)
- Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells (2015) (502)
- Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases (2006) (460)
- Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt (2004) (446)
- An integrated expression atlas of miRNAs and their promoters in human and mouse (2017) (361)
- Adhesion, migration and communication in melanocytes and melanoma. (2005) (358)
- Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma (2018) (356)
- Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. (2014) (352)
- Isolation of a novel population of multipotent adult stem cells from human hair follicles. (2006) (350)
- Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. (2017) (339)
- Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. (2005) (325)
- Life ins't flat: Taking cancer biology to the next dimension (2006) (307)
- Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E–mutated melanomas (2008) (299)
- Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. (2018) (294)
- Modeling genomic diversity and tumor dependency in malignant melanoma. (2008) (294)
- Rewired ERK-JNK signaling pathways in melanoma. (2007) (280)
- Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression. (2006) (272)
- Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness. (2002) (265)
- The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. (2005) (262)
- Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes (1994) (257)
- Epidermal Growth Factor Receptor Mediates Increased Cell Proliferation, Migration, and Aggregation in Esophageal Keratinocytes in Vitro and in Vivo * (2003) (254)
- Low-Level Monocyte Chemoattractant Protein-1 Stimulation of Monocytes Leads to Tumor Formation in Nontumorigenic Melanoma Cells1 (2001) (248)
- Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. (2006) (248)
- The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression When Combined with Docetaxel (2008) (230)
- Melanoma-stroma interactions: structural and functional aspects. (2002) (221)
- Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. (2013) (218)
- An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells. (2007) (218)
- Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. (2010) (214)
- Tumors as elusive targets of T-cell-based active immunotherapy. (2003) (210)
- Normal human melanocyte homeostasis as a paradigm for understanding melanoma. (2005) (202)
- Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models (2016) (197)
- Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations (2018) (196)
- Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. (2016) (195)
- The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. (2007) (184)
- B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma (2018) (183)
- Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility. (2018) (182)
- Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion (2010) (181)
- Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses (2018) (180)
- Melanoma and the tumor microenvironment (2008) (174)
- Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma. (2013) (173)
- The Role of Altered Cell–Cell Communication in Melanoma Progression (2003) (168)
- Transforming growth factor-beta1 increases survival of human melanoma through stroma remodeling. (2001) (166)
- Human dermal stem cells differentiate into functional epidermal melanocytes (2010) (164)
- Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors (1987) (159)
- Melanoma cell lines from different stages of progression and their biological and molecular analyses (1997) (159)
- Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion. (2005) (157)
- FANTOM5 CAGE profiles of human and mouse samples (2017) (153)
- BRAF as a potential therapeutic target in melanoma and other malignancies. (2003) (153)
- Melanoma stem cells: the dark seed of melanoma. (2008) (152)
- PLX4032, a potent inhibitor of the B‐Raf V600E oncogene, selectively inhibits V600E‐positive melanomas (2010) (150)
- Insulin-like Growth Factor-1 Induces Survival and Growth of Biologically Early Melanoma Cells through Both the Mitogen-activated Protein Kinase and β-Catenin Pathways (2001) (148)
- Up‐regulation of ephrin‐a1 during melanoma progression (1999) (147)
- Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. (2010) (144)
- Resistance to BRAF inhibitors: unraveling mechanisms and future treatment options. (2011) (140)
- Fibroblast‐dependent differentiation of human microvascular endothelial cells into capillary‐like, three‐dimensional networks (2002) (139)
- A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. (2008) (134)
- A stress-induced early innate response causes multidrug tolerance in melanoma (2014) (133)
- Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture (2012) (133)
- A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. (2017) (131)
- PAK Signaling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas (2017) (128)
- Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells. (2007) (124)
- Fibroblasts contribute to melanoma tumor growth and drug resistance. (2011) (121)
- Pro-Invasive Activity of the Hippo Pathway Effectors YAP and TAZ in Cutaneous Melanoma (2013) (121)
- PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. (2018) (118)
- An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling. (2016) (118)
- In vitro three-dimensional tumor microenvironment models for anticancer drug discovery (2008) (115)
- Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma. (2007) (115)
- Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1 (2006) (113)
- Mutant V600E BRAF Increases Hypoxia Inducible Factor-1α Expression in Melanoma (2007) (112)
- Active Notch1 confers a transformed phenotype to primary human melanocytes. (2009) (110)
- Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis (1995) (110)
- NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. (2010) (109)
- A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors. (2011) (108)
- Therapeutic destruction of insulin receptor substrates for cancer treatment. (2013) (108)
- Periostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor-invasive signature in esophageal cancer. (2010) (108)
- Defining the Conditions for the Generation of Melanocytes from Human Embryonic Stem Cells (2006) (107)
- Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. (2012) (107)
- Tumor-associated B-cells induce tumor heterogeneity and therapy resistance (2017) (105)
- Personalized Preclinical Trials in BRAF Inhibitor–Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies (2015) (103)
- Immunohistochemical evidence of cytokine networks during progression of human melanocytic lesions (1999) (102)
- A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma. (2017) (100)
- The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression (2011) (100)
- Monoclonal antibody detection of a circulating tumor-associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric, and pancreatic carcinoma (1982) (99)
- Induction of p21WAF1/CIP1and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16INK4a (1999) (99)
- Identification of secreted proteins that reflect autophagy dynamics within tumor cells (2015) (98)
- CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1 (2006) (97)
- Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression. (2008) (96)
- BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth (2015) (95)
- Pre-clinical modeling of cutaneous melanoma (2020) (94)
- A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent (2013) (93)
- Death Induction by Recombinant Native TRAIL and Its Prevention by a Caspase 9 Inhibitor in Primary Human Esophageal Epithelial Cells* (2004) (92)
- Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles (2012) (91)
- Microenvironmental influences in melanoma progression (2007) (89)
- The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. (2008) (89)
- Intratumoral heterogeneity as a therapy resistance mechanism: role of melanoma subpopulations. (2012) (88)
- Melanoma central nervous system metastases: current approaches, challenges, and opportunities (2016) (88)
- Human melanoma: Development and progression (1990) (88)
- Targeting Intracellular Signaling Pathways as a Novel Strategy in Melanoma Therapeutics (2005) (88)
- The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells (2013) (87)
- Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population (2010) (86)
- The emerging roles of Oct4 in tumor-initiating cells. (2015) (86)
- Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma. (2007) (85)
- Developmental pathways activated in melanocytes and melanoma. (2014) (83)
- ATF2 confers radiation resistance to human melanoma cells (1998) (82)
- Similar biological activities of two isostructural ruthenium and osmium complexes. (2008) (82)
- Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts (2019) (81)
- Contribution of phosphatidylinositol 3‐kinase to radiation resistance in human melanoma cells (1999) (79)
- The state of melanoma: challenges and opportunities (2016) (79)
- Recent advances in melanoma biology. (2004) (79)
- Mel-CAM-specific genetic suppressor elements inhibit melanoma growth and invasion through loss of gap junctional communication (2001) (78)
- Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells. (2010) (77)
- Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival (2018) (77)
- Targeting BRAF in Advanced Melanoma: A First Step toward Manageable Disease (2011) (77)
- Photocarcinogenesis in human adult skin grafts. (2002) (77)
- The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast. (2002) (76)
- Wnt5A promotes an adaptive, senescent‐like stress response, while continuing to drive invasion in melanoma cells (2015) (76)
- Experimental local therapy of human melanoma with lytic magainin peptides (1995) (75)
- Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence. (2017) (74)
- The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes. (2009) (74)
- Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway (2008) (68)
- Rhenium Complexes with Visible‐Light‐Induced Anticancer Activity (2013) (68)
- Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors (2014) (68)
- microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB (2016) (67)
- Dermis‐derived stem cells: a source of epidermal melanocytes and melanoma? (2011) (65)
- Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma (2018) (65)
- Truncation of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis. (2004) (64)
- Targeting CD20 in melanoma patients at high risk of disease recurrence. (2012) (64)
- The many faces of Notch signaling in skin-derived cells. (2007) (63)
- Cancer testis antigens in human melanoma stem cells: Expression, distribution, and methylation status (2008) (63)
- EVIDENCE FOR MESENCHYMAL-LIKE SUBPOPULATIONS WITHIN SQUAMOUS CELL CARCINOMAS POSSESSING CHEMORESISTANCE AND PHENOTYPIC PLASTICITY (2010) (63)
- Polyunsaturated Fatty Acids from Astrocytes Activate PPAR Gamma Signaling in Cancer Cells to Promote Brain Metastasis. (2019) (63)
- Identification of a novel family of BRAF(V600E) inhibitors. (2012) (62)
- Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma. (2007) (62)
- Direct Reprogramming of Melanocytes to Neural Crest Stem‐Like Cells by One Defined Factor (2011) (61)
- Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells (2017) (59)
- Melanoma‐derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signature (2012) (59)
- A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers. (2017) (59)
- A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors (2019) (58)
- JARID1 Histone Demethylases: Emerging Targets in Cancer. (2017) (58)
- Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy (2021) (58)
- Selective evolutionary pressure from the tissue microenvironment drives tumor progression. (2005) (56)
- Osteonectin/SPARC induction by ectopic beta(3) integrin in human radial growth phase primary melanoma cells. (2002) (56)
- Heterogeneity in Melanoma. (2016) (55)
- Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation (2015) (55)
- Insulin-like growth factor-I-induced migration of melanoma cells is mediated by interleukin-8 induction. (2002) (54)
- The Anti-Melanoma Activity of Dinaciclib, a Cyclin-Dependent Kinase Inhibitor, Is Dependent on p53 Signaling (2013) (54)
- Cell-surface proteolysis, growth factor activation and intercellular communication in the progression of melanoma (2002) (53)
- Melanoma exosomes: messengers of metastasis (2012) (52)
- Molecular biology of human melanoma development and progression (1998) (51)
- Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines. (2017) (51)
- ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma. (2019) (50)
- Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas (2011) (50)
- Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. (2008) (50)
- CXC Chemokine Ligand 12 (Stromal Cell-Derived Factor 1α) and CXCR4-Dependent Migration of CTLs toward Melanoma Cells in Organotypic Culture1 (2005) (49)
- Melanoma models for the next generation of therapies. (2021) (49)
- Crosstalk in skin: melanocytes, keratinocytes, stem cells, and melanoma (2016) (48)
- Changes in Aged Fibroblast Lipid Metabolism Induce Age-dependent Melanoma Cell Resistance to Targeted Therapy Via the Fatty Acid Transporter FATP2. (2020) (48)
- What is a good model for melanoma? (2010) (47)
- Nuclear redistribution of BRCA1 during viral infection. (1998) (47)
- Notch4 Signaling Induces a Mesenchymal-Epithelial-like Transition in Melanoma Cells to Suppress Malignant Behaviors. (2016) (46)
- Distinct histone modifications denote early stress-induced drug tolerance in cancer (2017) (45)
- Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses. (2019) (45)
- Role of cadherins and matrixins in melanoma (2001) (44)
- Fibroblast growth factor‐2 but not Mel‐CAM and/or β3 integrin promotes progression of melanocytes to melanoma (2003) (43)
- Genomic characterisation of acral melanoma cell lines (2012) (43)
- Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogene. (2000) (42)
- Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo. (2006) (41)
- Endogenous p53 gene status predicts the response of human squamous cell carcinomas to wild-type p53 (2000) (41)
- miR‐200c/Bmi1 axis and epithelial–mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment (2015) (41)
- Stimulation of human colonic epithelial cells by leukemia inhibitory factor is dependent on collagen‐embedded fibroblasts in organotypic culture (2003) (40)
- PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma (2016) (40)
- An Engineered PAX3-KRAB Transcriptional Repressor Inhibits the Malignant Phenotype of Alveolar Rhabdomyosarcoma Cells Harboring the Endogenous PAX3-FKHR Oncogene (2000) (40)
- Oncogenic BRAF-Mediated Melanoma Cell Invasion. (2016) (39)
- Old disease, new culprit: Tumor stem cells in cancer (2007) (39)
- JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers. (2016) (39)
- Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma. (2019) (39)
- Distinct MHC gene expression patterns during progression of melanoma (2009) (38)
- Melanoma from bench to bedside: meeting report from the 6th international melanoma congress (2010) (38)
- Stem-like cells and therapy resistance in squamous cell carcinomas. (2012) (37)
- Evolution of delayed resistance to immunotherapy in a melanoma responder (2021) (37)
- The molecular pathology of cutaneous melanoma. (2010) (37)
- VEGF‐A and αVβ3 integrin synergistically rescue angiogenesis via N‐Ras and PI3‐K signaling in human microvascular endothelial cells (2003) (37)
- Matricellular Proteins Produced by Melanocytes and Melanomas: In Search for Functions (2008) (36)
- Monoclonal antibody detection of a circulating tumor-associated antigen. II. A longitudinal evaluation of patients with colorectal cancer (1982) (36)
- Comparative Secretome Analysis of Epithelial and Mesenchymal Subpopulations of Head and Neck Squamous Cell Carcinoma Identifies S100A4 as a Potential Therapeutic Target* (2013) (36)
- GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation (2012) (35)
- Mitochondrial oxidative stress as a novel therapeutic target to overcome intrinsic drug resistance in melanoma cell subpopulations (2015) (35)
- Cancer interaction with the bone microenvironment: a workshop of the National Institutes of Health Tumor Microenvironment Study Section. (2006) (35)
- From cancer stem cells to tumor maintenance in melanoma (2011) (35)
- A stress-induced early innate response causes multidrug tolerance in melanoma (2015) (35)
- Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines (2020) (34)
- Adenoviral‐mediated gene transfer in wound healing: acute inflammatory response in human skin in the SCID mouse model (2008) (34)
- Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma. (2012) (34)
- Learning the ABCs of melanoma-initiating cells. (2008) (33)
- Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment (2021) (33)
- Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function (2017) (32)
- Growth factors in melanoma (1991) (32)
- Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors. (2011) (32)
- KIT in melanoma: many shades of gray. (2015) (31)
- The FBXO4 Tumor Suppressor Functions as a Barrier to BrafV600E-Dependent Metastatic Melanoma (2013) (31)
- Meeting report: The future of preclinical mouse models in melanoma treatment is now (2013) (31)
- Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming (2018) (30)
- Reversal of melanocytic malignancy by keratinocytes is an E-cadherin-mediated process overriding beta-catenin signaling. (2004) (29)
- Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho (2017) (29)
- Stromal changes in the aged lung induce an emergence from melanoma dormancy (2020) (29)
- Growth factors and cytokines in melanoma (1993) (27)
- The role of Orai–STIM calcium channels in melanocytes and melanoma (2016) (27)
- EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas (2013) (26)
- MFF REGULATION OF MITOCHONDRIAL CELL DEATH IS A THERAPEUTIC TARGET IN CANCER. (2019) (25)
- Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma (2018) (25)
- IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance (2020) (25)
- Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities (2019) (25)
- Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer. (2017) (25)
- Isolation and cultivation of dermal stem cells that differentiate into functional epidermal melanocytes. (2012) (24)
- Large-scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines (2020) (24)
- Targeting RRM2 and Mutant BRAF Is a Novel Combinatorial Strategy for Melanoma (2016) (24)
- Towards the targeted therapy of melanoma. (2006) (24)
- Cancer stem cells are everywhere (2009) (24)
- Nivolumab in combination with ipilimumab for the treatment of melanoma (2015) (23)
- Slit-Robo: neuronal guides signal in tumor angiogenesis. (2003) (23)
- Paracrine signaling between carcinoma cells and mesenchymal stem cells generates cancer stem cell niche via epithelial-mesenchymal transition. (2012) (23)
- LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. (2014) (23)
- ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma. (2017) (22)
- ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression. (2022) (21)
- Targeting the stromal fibroblasts: a novel approach to melanoma therapy (2005) (21)
- Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes (2008) (21)
- Narrowing the knowledge gaps for melanoma (2012) (21)
- An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling. (2016) (21)
- The vascular phenotype of melanoma metastasis (2004) (20)
- Cultivation of normal human epidermal melanocytes in the absence of phorbol esters. (2005) (20)
- Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells (2018) (20)
- SECTM1 Produced by Tumor Cells Attracts Human Monocytes Via CD7-mediated Activation of the PI3K Pathway (2013) (20)
- Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma (2020) (20)
- Embryogenesis meets tumorigenesis (2006) (19)
- Genome‐wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy (2019) (19)
- BRAF inhibitor unveils its potential against advanced melanoma. (2010) (19)
- VEGF-A and alphaVbeta3 integrin synergistically rescue angiogenesis via N-Ras and PI3-K signaling in human microvascular endothelial cells. (2003) (19)
- UV-induced Wnt7a in the human skin microenvironment specifies the fate of neural crest -like cells via suppression of Notch (2015) (19)
- BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells (2019) (19)
- New approaches to the biology of melanoma: a workshop of the National Institutes of Health Pathology B Study Section. (2002) (18)
- Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF-mutant melanoma (2021) (18)
- Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization. (2012) (18)
- MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression. (2018) (18)
- The State of Melanoma: Emergent Challenges and Opportunities (2021) (18)
- Loitering with intent: new evidence for the role of BRAF mutations in the proliferation of melanocytic lesions. (2004) (18)
- The role of tumor microenvironment in melanoma therapy resistance. (2016) (17)
- Integrating tumor‐initiating cells into the paradigm for melanoma targeted therapy (2009) (17)
- Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma (2016) (17)
- Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment (2021) (17)
- Isolation, characterization, and differentiation of human multipotent dermal stem cells. (2013) (16)
- Corrections: An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling (Cancer Cell (2016) 30(3) (501–503) (S1535610816302847) (10.1016/j.ccell.2016.06.024)) (2016) (16)
- ARID2 deficiency correlates with the response to immune checkpoint blockade in melanoma. (2020) (16)
- High levels of CUG-initiated FGF-2 expression cause chromatin compaction, decreased cardiomyocyte mitosis, and cell death (2003) (16)
- Microscale solution IEF combined with 2‐D DIGE substantially enhances analysis depth of complex proteomes such as mammalian cell and tissue extracts (2008) (16)
- TRIM15 and CYLD regulate ERK activation via lysine 63-linked polyubiquitination (2021) (16)
- MEK'ing the most of p53 reactivation therapy in melanoma. (2012) (15)
- PIM kinases as therapeutic targets against advanced melanoma (2016) (15)
- Unraveling mysteries of the multifunctional protein SPARC. (2007) (15)
- Beyond ABC: another mechanism of drug resistance in melanoma side population. (2012) (15)
- A systems biology analysis of metastatic melanoma using in‐depth three‐dimensional protein profiling (2010) (15)
- Endothelin-3 stimulates survival of goblet cells in organotypic cultures of fetal human colonic epithelium. (2008) (14)
- Targeting the cyclin-dependent kinase 5 in metastatic melanoma (2020) (14)
- Abstract 5194: Notch regulates squamous differentiation, cell plasticity and tumor heterogeneity in esophageal carcinoma (2011) (14)
- Pathway signatures derived from on-treatment tumor specimens predict response to anti-PD1 blockade in metastatic melanoma (2021) (14)
- Acetylsalicylic Acid Governs the Effect of Sorafenib in RAS-Mutant Cancers (2017) (14)
- Molecular targets in melanoma: Strategies and challenges for diagnosis and therapy (2006) (14)
- Fibroblast growth factor–binding protein expression changes with disease progression in clinical and experimental human squamous epithelium (2001) (13)
- Heparin/endothelial cell growth supplement regulates matrix gene expression and prolongs life span of vascular smooth muscle cells through modulation of interleukin-1 (1999) (13)
- CCN 3 controls 3 D spatial localization of melanocytes in the human skin through DDR 1 (2006) (13)
- Enhancing the evaluation of PI3K inhibitors through 3D melanoma models (2016) (13)
- Recent Advances in Melanoma and Melanocyte Biology. (2017) (13)
- FMelanoma from bench to bedside: meeting report from the 6th international melanoma congress. Pigment Cell Melanoma Res. 23, 14-26 (2010) (13)
- Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma (2022) (12)
- Unraveling the mysteries of IGF-1 signaling in melanoma. (2008) (12)
- Publisher Correction: Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma (2018) (12)
- Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts (2021) (12)
- Taking the guesswork out of uveal melanoma. (2010) (12)
- The promise of 3D skin and melanoma cell bioprinting. (2016) (11)
- Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic BRAF signaling. (2021) (11)
- Nongenetic Mechanisms of Drug Resistance in Melanoma (2020) (11)
- Frontiers in pigment cell and melanoma research (2018) (11)
- p16INK4A and familial melanoma. (2003) (11)
- HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors (2022) (11)
- In vivo and ex vivo MR imaging of slowly cycling melanoma cells (2011) (11)
- Tumor progression, biology, and host response in melanoma (1992) (10)
- Endothelial cells as targets for tumor therapy. (1999) (10)
- Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma (2017) (10)
- Information sharing and collateral damage. (2005) (10)
- Role of transforming growth factor-α-related peptides in the autocrine/paracrine control of experimental breast cancer growthin vitro by estradiol, prolactin, and progesterone (1990) (10)
- SPANX Control of Lamin A/C Modulates Nuclear Architecture and Promotes Melanoma Growth (2020) (10)
- Driving in the melanoma landscape (2009) (10)
- Persister state-directed transitioning and vulnerability in melanoma (2020) (9)
- Combining DNA Damage Induction with BCL-2 Inhibition to Enhance Merkel Cell Carcinoma Cytotoxicity (2020) (9)
- Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis (2018) (9)
- Gene expression profiling of melanoma cells – searching the haystack (2005) (9)
- MX 2 is a novel regulator of cell cycle in melanoma cells (2019) (9)
- Cracking the system: melanoma complexity demands new therapeutic approaches (2009) (8)
- Inhibition of endothelin-B receptor signaling synergizes with MAPK pathway inhibitors in BRAF mutated melanoma (2021) (8)
- Gα13 mediates human cytomegalovirus‐encoded chemokine receptor US28‐induced cell death in melanoma (2015) (8)
- Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma. (2020) (8)
- Metastatic melanoma cells. Introduction. (2005) (8)
- A Melanoma Patient-Derived Xenograft Model. (2019) (8)
- Emerging concepts and technologies in melanoma research (2002) (8)
- Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas (2018) (8)
- Erratum: Corrigendum: High-throughput oncogene mutation profiling in human cancer (2007) (7)
- Inhibiting insulin and mTOR signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma (2020) (7)
- Will engineered T cells expressing CD20 scFv eradicate Melanoma? (2011) (7)
- Erratum: High-throughput oncogene mutation profiling in human cancer (Nature Genetics (2007) 39, (347-351)) (2007) (7)
- Functional Profiling of Live Melanoma Samples Using a Novel Automated Platform (2012) (7)
- Defining microenvironments within mouse models that enhance tumor aggressiveness (2009) (7)
- Embryonic stem cells as a model for studying melanocyte development. (2010) (7)
- 1205Lu is Human Melanoma Depending on the Source (2016) (7)
- Characterization of monoclonal antibodies directed to the amino-terminus of the WT1, Wilms' tumor suppressor protein. (1998) (7)
- Transforming Growth Factor-1 Increases Survival of Human Melanoma through Stroma Remodeling 1 (2001) (7)
- On the TRAIL to overcome BRAF-inhibitor resistance. (2014) (7)
- The emerging roles of Oct 4 in tumor-initiating cells (2015) (6)
- The ups and downs of transcription factors in melanoma. (2010) (6)
- Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function (2021) (6)
- Linking SOX10 to a slow-growth resistance phenotype (2014) (6)
- Immunotargeting of tumor subpopulations in melanoma patients (2012) (6)
- Combination therapy of immunocytokines with ipilimumab: a cure for melanoma? (2013) (6)
- [Melanoma-stroma interactions and melanoma progression]. (2003) (5)
- Roadmap for new opportunities in melanoma research. (2007) (5)
- The macrophage: Switches from a passenger to a driver during anticancer therapy (2015) (5)
- Indomethacin to the rescue of TRAIL-resistant melanomas. (2014) (5)
- Isolation of melanoma cell subpopulations using negative selection. (2014) (5)
- Preclinical platforms to study therapeutic efficacy of human γδ T cells (2022) (4)
- The macrophage: a new factor in UVR-induced melanomagenesis. (2013) (4)
- Anti-tumor Activity of a Mitochondrial Targeted HSP90 Inhibitor in Gliomas. (2022) (4)
- Mitochondrial biogenesis meets chemoresistance in BRAF-mutant melanoma (2016) (4)
- Establishing Human Skin Grafts in Mice as Model for Melanoma Progression. (2015) (4)
- Induction of metallothionein expression during monocyte to melanoma-associated macrophage differentiation (2012) (4)
- Salmonella typhimurium as a novel RNA interference vector for cancer gene therapy (2008) (4)
- There is a world beyond protein mutations: the role of non‐coding RNAs in melanomagenesis (2013) (4)
- Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response (2018) (4)
- Corrigendum: Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance (2018) (4)
- Sorting through the many opportunities for melanoma therapy (2011) (4)
- Cancer: Complexion matters (2012) (4)
- Molecular biology of tumor antigens. (1989) (4)
- Human nevi: no longer precursors of melanomas? (2012) (4)
- Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance (2021) (3)
- Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies (2021) (3)
- Erratum: Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma (Molecular Cell (2020) 77(3) (633–644.e5), (S109727651930838X), (10.1016/j.molcel.2019.11.009)) (2020) (3)
- PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery (2022) (3)
- The Dynamic Roles of Cell-Surface Receptors in Melanoma Development (2006) (3)
- 16 – Melanocyte and Melanoma Cell Lines (1994) (3)
- clampFISH 2.0 enables rapid, scalable amplified RNA detection in situ (2022) (3)
- New dream team for melanoma therapy (2012) (3)
- Author Correction: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts (2021) (2)
- Pre-clinical modeling of cutaneous melanoma (2020) (2)
- Relapse of melanoma after successful adoptive T‐cell therapy: escape through inflammation‐induced phenotypic melanoma cell plasticity (2013) (2)
- The Janus-faced role of KDM5B heterogeneity in melanoma: differentiation as a situational driver of both growth arrest and drug-resistance (2020) (2)
- Epigenetic Silencing of BMP6 by the SIN3A–HDAC1/2 Repressor Complex Drives Melanoma Metastasis via FAM83G/PAWS1 (2021) (2)
- Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (2021) (2)
- 569 POSTER Antitumor activity of PLX4032, a novel B-Raf V600E Inhibitor (2006) (2)
- Abstract 420: The role of tumor microenvironment in therapy resistance and melanoma progression (2015) (2)
- The novel MEK1/2 inhibitor AZD6244 (ARRY-142886) inhibits the growth of melanomas harboring the BRAF V600E mutation in vitro and in vivo (2007) (2)
- NUMB as a Therapeutic Target for Melanoma (2021) (2)
- TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors. (2021) (2)
- Structural and Functional Characteristics of Human Melanoma (1991) (2)
- Melanom‐Stroma‐Interaktionen und ihre Bedeutung für die Melanomprogression (2003) (2)
- The novel MEK inhibitor AZD6244/ARRY142886 inhibits the growth of melanomas harboring the BRAFV600E mutation in vitro and in vivo (2006) (2)
- MCU controls melanoma progression through a redox‐controlled phenotype switch (2022) (2)
- Metastatic potential in clonal melanoma cells is driven by a rare, early-invading subpopulation (2023) (2)
- The signaling mute hCMV chemokine receptor US28R129A prevents melanoma growth (2006) (1)
- Targeting the ATR-Chk1 axis with PARP inhibition results in tumor regression in BRCA mutant models (2017) (1)
- Melanoma Subpopulations with Cancer Stem Cell Phenotypes (2014) (1)
- Tumor Microenvironment for Melanoma Cells (2011) (1)
- Tumor and Stem Cell Biology ANOTCH 3-MediatedSquamousCell DifferentiationProgram Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors (2011) (1)
- 40 years in melanoma research: an interview with Meenhard Herlyn about his career in research and the outlook for the field. (2016) (1)
- The Transformed Phenotype of Melanocytes (2007) (1)
- Farming cells to rebuild skin and melanoma (2007) (1)
- Targeting UGCG overcomes resistance to lysosomal autophagy inhibition. (2022) (1)
- Abstract 3223: A true orthotopic ovarian cancer patient-derived xenograft (PDX) model (2015) (1)
- Epigenetic remodelling of H3K9Me3 leads to early stress induced drug tolerance in cancer (2016) (1)
- Abstract 659: Overexpression of TPX2 accelerates cell cycle progression in melanoma and is an indicator of response to Aurora A kinase inhibitors (2010) (1)
- P1-03-09: Significance of FAP, SMA and CD31 Expression in the Stroma of Breast Cancer. (2011) (1)
- Corrigendum to “Reversal of melanocytic malignancy by keratinocytes is an E-cadherin-mediated process overriding β-catenin signaling” [Exp. Cell Res. 297 (2004) 142–151] (2005) (1)
- A Modified Nucleoside 6-Thio-2′-Deoxyguanosine Exhibits Antitumor Activity in Gliomas (2021) (1)
- The great escape: another way for melanoma to leave physiological control? (2003) (1)
- Suppression of p16 increases nucleotide synthesis via mTORC1 (2018) (1)
- Functional consequence of variation in melanoma antigen expression (2004) (1)
- The microenvironment is the key determinant of melanoma drug resistance (2006) (1)
- Crosstalk in skin: melanocytes, keratinocytes, stem cells, and melanoma (2016) (1)
- Differential expression of connexins in melanoma and adjacent epidermis (2004) (1)
- A signaling mute hCMV chemokine receptor prevents melanoma growth (2007) (1)
- Enforced polarization of melanoma cells towards a JARID1B-high phenotype exhausts tumour fitness (2017) (1)
- Tumor-associated B-cells induce tumor heterogeneity and therapy resistance (2017) (1)
- Malignant Melanoma Modeling Genomic Diversity and Tumor Dependency in Updated (2008) (1)
- Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy (2021) (1)
- Targeting WEE1/AKT restores p53-dependent NK cell activation to induce immune checkpoint blockade responses in 'cold' melanoma. (2022) (1)
- MSX1 promotes melanoma progression via neural crest-like reprogramming (2016) (1)
- Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy (2018) (1)
- Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3′ untranslated region of TRIT1 (2015) (1)
- Tumorigenesis and Neoplastic Progression The Role of BRAF Mutation and p 53 Inactivation during Transformation of a Subpopulation of Primary Human Melanocytes (2010) (1)
- Melanoma (2018) (1)
- Abstract A08: Targeting the ATR/CHK1 axis in BRCA1/2 mutant ovarian cancer using an orthotopic patient-derived xenograft (PDX) model. (2016) (1)
- Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery. (2021) (1)
- Abstract 70: Loss of cellular senescence checkpoint functions reveals the oncogene characteristics of Notch1 in squamous cell carcinomas (2012) (1)
- Tumor-associated antigen expression and growth requirements predict tumorigenesis in squamous cell carcinoma (2001) (1)
- A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells (2022) (1)
- Multiomics profiling of longitudinal melanoma specimens unravels molecular mechanisms of resistance to sequential targeted and cancer immunotherapies. (2020) (1)
- Zonula Occludens Protein-1 (2015) (1)
- Hypoxia inducible factor-1α regulates cyclooxgenase-2 and prostaglandin E synthase in esophageal cancer. (2008) (1)
- The basic biology of melanoma: 010 (1997) (1)
- The role of ultraviolet light in melanomagenesis (2002) (1)
- Abstract CN04-03: Esophageal cancer and the tumor microenvironment (2010) (0)
- Author ' s response to reviews Title : Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles (2012) (0)
- Abstract A01: A comprehensive collection of patient derived xenografts of human melanoma with clinical, genomic, and biological characterization (2016) (0)
- B cells sustain inflammation and improve survival in human melanoma (2018) (0)
- Role of stem cells in melanoma progression: hopes for a better treatment (2007) (0)
- Transcription Factors Expansion of EMT-Competent Cells That Express the ZEB A NOTCH 3-Mediated Squamous Cell Differentiation Program Limits (2011) (0)
- sample information of the human samples (2017) (0)
- Abstract 687: Compound screen identifies PIM kinases as therapeutic targets for melanoma (2015) (0)
- Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells (2018) (0)
- Phylogenetic analysis of longitudinal melanoma samples to reveal convergent evolution and markers of immunotherapy resistance. (2018) (0)
- 52. BrMPANEL: A PUBLIC RESOURCE OF ORGANOTROPIC CELL LINES (2020) (0)
- Epidermal Growth Factor Receptor Inhibition’s Effects on Invasion within Head and Neck Squamous Cell Carcinomas (2012) (0)
- Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis (2018) (0)
- Boris Bastian (2010) (0)
- Abstract 1679: Notch4 mediates mesenchymal-epithelial-like transition in melanoma (2016) (0)
- 251 A Functional Interplay Between TGF- and Notch Signaling Determines Esophageal Cancer Cell Fates (2012) (0)
- Abstract 1225: A unified model of RAF inhibitor action determines inhibitor activity in BRAF-dependent tumors (2017) (0)
- 662 Numb is induced by GSK3 inhibition and inhibits melanoma migration, invasion and metastasis (2016) (0)
- Abstract A13: MSX1-induced neural crest-like reprograming promotes melanoma progression (2015) (0)
- Abstract IA8: BRAF and MEK resistance in melanoma (2012) (0)
- Melanoma from bench to bedside: Meeting report from the 6th international melanoma congress (Pigment Cell and Melanoma Research (2010) 23, (14-26 )) (2010) (0)
- Tumor Regression When Combined with Docetaxel ( ARRY-142886 ) Induces Growth Arrest in Melanoma Cells Signal-Regulated Kinase Kinase Inhibitor AZD 6244 The Mitogen-Activated Protein / Extracellular (2007) (0)
- Abstract B27: Wnt5A-expressing melanoma cells show classical markers of senescence following radiation and therapeutic stress, but retain the ability to metastasize and proliferate at distant sites (2015) (0)
- BRAF in complex with an organic inhibitor 7898734 (2012) (0)
- Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth (2023) (0)
- Tumorigenesis and Neoplastic Progression Dysregulation of Claudin-7 Leads to Loss of E-Cadherin Expression and the Increased Invasion of Esophageal Squamous Cell Carcinoma Cells (2007) (0)
- Abstract 1508: UV-induced Wnt7a in the human skin microenvironment specifies the fate of neural crest -like cells via suppression of Notch (2015) (0)
- Abstract 2684: An early innate stress response precedes acquired drug resistance in melanoma (2015) (0)
- Abstract IA01: Strategies for targeted and immune therapy in melanoma (2020) (0)
- Treatment Options Resistance to BRAF Inhibitors: Unraveling Mechanisms and Future (2011) (0)
- Mesenchymal Transition - Stem Cells Generates Cancer Stem Cell Niche via Epithelial Paracrine Signaling between Carcinoma Cells and Mesenchymal (2012) (0)
- Adenoviral-mediated PDGF-B over-expression enhanced re-epithelialization is mediated by TGF-α (2000) (0)
- genomic coordinates of the mouse CAGE peaks (2017) (0)
- Abstract A66: K12/SECTM1 promotes melanoma tumor progression via upregulation of integrin β3 expression (2009) (0)
- Connexins are differentially expressed in melanoma and adjacent epidermis (2004) (0)
- Abstract 1244: The requirement of autophagy pathway for drug-induced senescence in human melanoma cells by AZD1152 (2011) (0)
- 677 Inactivation of the Retinoblastoma Protein-Dependent Senescence Checkpoint Functions Permits Notch1 to Gain Oncogenic Tumor Promoting Activity (2013) (0)
- Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts (2020) (0)
- Abstract B46: Use of a novel orthotopic ovarian cancer transplant patient derived xenograft model as a preclinical platform for bench to bedside research. (2016) (0)
- Abstract 5833: Escape form adaptive drug tolerance through OGT and TET1 mediated H3K4me3 remodeling in MAPKi resistant melanoma (2018) (0)
- Targeted therapy of melanoma: Novel kinase inhibitors with potent and specific anti-melanoma activity (2009) (0)
- Abstract 2294: IGF-independent regulation of EMT by insulin-like growth factor binding protein-3 in transformed human esophageal cells (2010) (0)
- Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment (2022) (0)
- Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance (2019) (0)
- Repurposing an HIV drug to improve efficacy of targeted therapy in melanoma (2016) (0)
- Abstract C29: Periostin, a regulator of adhesion, is a novel effector of tumor invasion (2009) (0)
- Abstract C77: A mesenchymal‐like subpopulation within squamous cell carcinomas with chemotherapy resistance and phenotypic plasticity (2009) (0)
- A 3-D method enhances in-depth analysis of complex proteomes such as mammalian cell and tissue extracts (2009) (0)
- Targeting BRAF/MEK in melanoma: new hope or another false dawn? (2007) (0)
- From Cancer Stem Cells to Tumor Maintenance in (2011) (0)
- A signaling mutant of US28 with growth inhibiting properties (2006) (0)
- W1748 Esophageal Stem Cells Have the Capacity for Self-Renewal and Lineage Specification (2008) (0)
- A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis (2022) (0)
- Abstract 1517: G0-like cells support an oral cancer stem cell pool by transitioning to a JARID1B-high state (2015) (0)
- The Notch and β-Catenin Pathways (2012) (0)
- Abstract 2842: Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models of melanoma identify c-Met as an effective second line combination therapy target (2015) (0)
- 597 Endothelin-3 Stimulates Survival of Goblet Cells in Organotypic Cultures of Human Colonic Epithelium (2008) (0)
- ANOTCH3-MediatedSquamousCellDifferentiationProgram Limits Expansion of EMT-Competent Cells That Express the (2011) (0)
- Retraction Note: IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance (2021) (0)
- Abstract 4668: Targeted, massively parallel sequencing identifies novel genetic subsets of cutaneous melanoma (2015) (0)
- Combining genetic analyses and pre-clinical studies in melanoma defines multiple sub-populations with differential responses to targeted therapies (2008) (0)
- The hCMV chemokine receptor US28 prevents melanoma growth (2007) (0)
- Abstract 5480: Effect of the Smac mimetic TL32711 in combination with TRAIL or TNF alpha on a panel of melanoma cell lines (2011) (0)
- IGFBP3 Suppresses Reactive Oxygen Species and Cellular Senescence Response to Facilitate TGF-β-Mediated EMT (2011) (0)
- Abstract 1682: Non-V600 BRAF mutants in melanoma: Multiple MAPK mutations and distinctive RNA expression (2019) (0)
- Abstract 966: All stressed out: Phenoytpe plasticity and therapy resistance in melanoma (2022) (0)
- Notch4 mediated MET-like transition involves crosstalk with non-canonical WNT signalling in melanoma (2016) (0)
- Challenges in the humanized mouse model for cancer: A commentary (2021) (0)
- Tumor-derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors. (2023) (0)
- Abstract SY12-02: Dynamic stemness in melanoma (2011) (0)
- Abstract 711: Understanding the mechanisms of resistance to BRAF inhibitors in melanoma (2011) (0)
- ERK Hyperactivation Serves as a Unified Mechanism of Escape in Intrinsic and Acquired CDK4/6 Inhibitor Resistance in Acral Lentiginous Melanoma (2023) (0)
- Abstract #5675: Increased cell survival and drug resistance due to SPARC-mediated activation of a FAK/ILK-PI3K/Akt signaling axis in malignant melanoma (2009) (0)
- Abstract PR18: Comparative screening of skin-derived NCSCs, melanocytes, and melanoma developmental programs reveals LPAR1 in MAPKi resistance (2020) (0)
- EGFR and Notch Determine Esophageal Cell Fates Through an Antagonistic Crosstalk (2011) (0)
- Abstract LB-149: Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy (2019) (0)
- IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance (2020) (0)
- CYTOKINE AND GROWTH FACTOR MODULATION OF CELL CYCLE EVENTS IN HUMAN MELANOMA CELL LINES (1998) (0)
- Retraction Note: IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance (2021) (0)
- Publisher Correction: Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma (2018) (0)
- 237 Transforming Growth Factor-β and Notch1 Cooperate to Repress NOTCH3 to Facilitate Epithelial-Mesenchymal Transition and Tumor Initiating Capability in Esophageal Squamous Cell Carcinoma (2013) (0)
- Abstract 1018: Structural features of novel dimeric quinacrines that have single-agent antitumor activity determine the mechanism of action: destabilization of mTORC1/lysosomal interaction versus DNA damage (2016) (0)
- Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics (2022) (0)
- 252 CD44 Defines Highly Plastic Esophageal Squamous Cancer Cells With Tumor Initiating Capabilities (2012) (0)
- Abstract LB083: BRAF dimer-selective inhibitors synergize with BRAF monomer-selective inhibitors to overcome adaptive resistance and retain therapeutic index (2022) (0)
- Abstract A26: Humanized mouse model: A model to understand mechanisms of immune non-responsiveness to immune checkpoint inhibitors in melanoma (2020) (0)
- Abstract B34: Global histone modifications define early stress induced drug tolerance in cancer (2016) (0)
- Identification of novel proteins and their pathways implicated in high metastatic potential of human melanoma cells using a 3-D method (2009) (0)
- Abstract 40: Targeting SOX10-deficient cells to reduce resistance to targeted therapy in melanoma (2021) (0)
- genomic coordinates of the human CAGE peaks (2017) (0)
- assay information of the mouse qualitycontrol samples for HeliScopeCAGE (2017) (0)
- Author Correction: Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis (2019) (0)
- Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses (2018) (0)
- Molecular Oncology: Melanoma (2013) (0)
- Etiology and Modeling of Human Melanoma: Illuminating the Dark Pathways of a Deadly Disease (2006) (0)
- 3D organotypic culture mimics melanoma staging. (2006) (0)
- First international melanoma research congress. (2003) (0)
- 337 Insulin-Like Growth Factor Binding Protein-3 Regulates Esophageal Tumor Initiating Capability via a Novel Insulin-Like Growth Factor-Independent Antioxidant Activity (2013) (0)
- Culture toward Melanoma Cells in Organotypic CXCR 4-Dependent Migration of CTLs ) and α Cell-Derived Factor 1 CXC Chemokine Ligand 12 ( Stromal (2005) (0)
- Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment (2022) (0)
- expression table of the human CAGE peaks (2017) (0)
- The viral chemokine receptor US28 mediates its anti-tumorigenic effect in melanoma via GNA13 (2011) (0)
- Wnt7a opposes Notch pathway to specify neural crest-like stem cell fate toward the melanocytic lineage in human skin (2013) (0)
- Abstract 5219: The LIM protein LIMD2 functions as an effector and biomarker for metastasis in multiple tumor types (2011) (0)
- 1237 Escape form adaptive drug tolerance through OGT and TET1 mediated H3K4me3 remodeling in MAPKi-resistant melanoma (2018) (0)
- Cancer Therapeutics Insights EGFR Inhibition Promotes an Aggressive Invasion Pattern Mediated by Mesenchymal-like Tumor Cells within Squamous Cell Carcinomas (2013) (0)
- COMP 374-Potent inhibitors of mutant-B-Raf and Fms kinases designed using a scaffold-based drug discovery approach (2008) (0)
- Abstract B12: PTEN modulates sensitivity to a novel ERK inhibitor in BRAFV600E-mutant melanomas (2012) (0)
- Differential gap junctional intercellular communication between melanoma cells and cells in their microenvironment (2005) (0)
- Abstract 992: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase (2014) (0)
- Autophagy Paradox: Strategizing Treatment Modality in Melanoma (2023) (0)
- 540 Epithelial Reconstitution Reveals Regulation of Differentiation and Cell Fate Decisions Through a Novel Interplay Between the Notch Signaling and Essential Cancer Genes in Esophageal Carcinogenesis (2009) (0)
- Stage-specific effects of Hepatocyte Growth Factor on epithelial-mesenchymal transcriptional regulators in melanocylic cells (2008) (0)
- High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping (2006) (0)
- Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas (2023) (0)
- Abstract 1182: Patient derived xenograft (PDX) of human melanoma to predict clinical responses (2014) (0)
- Abstracts of the Sixth International Conference on the Adjuvant Therapy of Malignant Melanoma (2007) (0)
- In Memoriam: Rajasekharan (Shyam) Somasundaram (1956-2021). (2021) (0)
- Abstract 78: A strategy for effective targeting of oncogenic BRAF signaling with increased therapeutic index using conformation-selective RAF and MEK inhibitors (2021) (0)
- Combination of sorafenib with aspirin synergistically target mutant NRAS melanoma (2016) (0)
- Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas (2018) (0)
- Inhibition of MEK with AZD6244 is cytostatic as a monotherapy in melanoma, but cytotoxic when combined with docetaxel leading to tumour regression in vitro and in vivo (2009) (0)
- INV 2 Development of targeted therapies of melanoma (2007) (0)
- Insulin-like Growth Factor-I-induced Migration of Melanoma Cells Is Mediated by Interleukin-8 Induction 1 (2002) (0)
- Molecular and Cellular Pathobiology LIMD 2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase (2014) (0)
- Randy Lomax, 1947–2016 (2016) (0)
- Induced pluripotent stem cells reprogramming overcomes technical limitations for highly pigmented adult melanocyte amplification and integration in 3D skin model (2022) (0)
- Abstract B41: BRAF targeting sensitizes resistant melanoma to cytotoxic T cells (2020) (0)
- The pharmacological activation of p53 as a novel strategy for melanoma therapy (2006) (0)
- Author Correction: Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis (2019) (0)
- Acknowledgements to reviewers (2015) (0)
- Targeting Signaling Pathways – In the Search of Melanoma’s Achilles’ Heel (2008) (0)
- Association of Zonula occludens (ZO) protein-1 with N-cadherin in human melanoma cells (2004) (0)
- Dermatology Research (2018) (0)
- Melanoma Therapeutic St rategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence Graphical (2017) (0)
- Abstract 523: Modeling the crosstalk between head and neck carcinomas and fibroblasts that underlies malignant invasion and drug resistance (2011) (0)
- Editorial Manager(tm) for PLoS ONE Manuscript Draft Manuscript Number: PONE-D-10-05386R2 Title: Extracellular Heat Shock Protein (Hsp)70 and Hsp90α Assist in Matrix Metalloproteinase-2 Activation and Breast Cancer Cell Migration and Invasion Short Title: Hsp70 and Hsp90α Assist in MMP-2 Activation (2011) (0)
- 93 A stress induced early innate response causes multi-drug tolerance in melanoma (2014) (0)
- Abstract 1683: Autophagy inhibition for cancer therapy. (2013) (0)
- Novel small molecule kinase inhibitors with potent and specific anti-melanoma activity (2009) (0)
- Cancer Stem Cells: Melanoma cancer stem cells (2009) (0)
- Abstract B32: Single-cell non-genetic heterogeneity confers drug resistance in melanoma (2016) (0)
- A systems biology analysis of metastatic melanoma using in‐depth three‐dimensional protein profiling (2011) (0)
- Induction of cellular stress via the p38 MAPK pathway drives VELCADE® (bortezomib)‐induced apoptosis in esophageal squamous cell carcinoma cells (2008) (0)
- Abstract 587: B-Raf status predicts response to pharmacological activation of p53 in melanoma (2011) (0)
- Randy Lomax – the passionate melanoma advocate and champion of the Melanoma Research Foundation (2012) (0)
- Therapeutic Targeting of the Melanoma Stem Cell Population (2008) (0)
- Stromal changes in the aged lung induce an emergence from melanoma dormancy (2022) (0)
- Report on the 1st Annual Melanoma Congress Meeting (2003) (0)
- t he Ups and downs of t ranscription Factors in Melanoma (2010) (0)
- Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma (2018) (0)
- Capitalizing on synthetic lethality in homologous recombination-deficient high-grade serous ovarian cancers with a novel ATR inhibitor (2016) (0)
- Biochemical and Functional Characterization of Aminopeptidase N Expressed by Human Melanoma Cells 1 (2006) (0)
- Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (2022) (0)
- Distinct epigenetic remodelling defines early stress-induced drug tolerance in melanoma (2018) (0)
- Abstract PR02: Humanized mouse melanoma model using patient-derived xenografts (2016) (0)
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