Megan Sykes

Q: What Schools Are Affiliated With Megan Sykes

Megan Sykes is affiliated with the following schools: University of California, Berkeley, California Institute of Technology, Stanford University, Columbia University, Massachusetts General Hospital, University of Vienna, Harvard University

Megan Sykes's AcademicInfluence.com Rankings

Megan Sykes

Engineering

#3310

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#4365

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Biomedical Engineering

#148

World Rank

#151

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engineering Degrees

Megan Sykes

Biology

#6336

World Rank

#9026

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Immunology

#325

World Rank

#338

Historical Rank

Neuroscience

#761

World Rank

#793

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biology Degrees

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Engineering
Biology

Megan Sykes's Degrees

Masters Biomedical Engineering Stanford University

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Megan Sykes's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Hematopoietic stem cell quiescence maintained by p21cip1/waf1. (2000) (1365)
HLA-mismatched renal transplantation without maintenance immunosuppression. (2008) (908)
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. (2013) (692)
Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue (2005) (586)
Mixed Allogeneic Chimerism And Renal Allograft Tolerance In Cynomolgus Monkeys (1995) (556)
Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment (2000) (526)
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche (2011) (484)
Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. (1999) (411)
Mixed chimerism and transplant tolerance. (2001) (405)
Mixed lymphohaemopoietic chimerism and graft-ver suslymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation (1999) (402)
Organ transplantation—how much of the promise has been realized? (2005) (381)
Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance (1998) (375)
Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen. (1994) (347)
Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance. (2004) (323)
Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning (1997) (323)
Xenotransplantation: current status and a perspective on the future (2007) (302)
Extreme Oxygen Sensitivity of Electronic Properties of Carbon Nanotubes (288)
Induction Of Kidney Allograft Tolerance After Transient Lymphohematopoietic Chimerism In Patients With Multiple Myeloma And End-Stage Renal Disease1 (2002) (274)
Myeloma Responses and Tolerance Following Combined Kidney and Nonmyeloablative Marrow Transplantation: In Vivo and In Vitro Analyses (2006) (265)
Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice (2009) (263)
Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. (2000) (258)
Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells. (2002) (248)
Long‐Term Results in Recipients of Combined HLA‐Mismatched Kidney and Bone Marrow Transplantation Without Maintenance Immunosuppression (2014) (240)
Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. (2000) (237)
HLA-mismatched renal transplantation without maintenance immunosuppression. (2013) (236)
Role for CD47-SIRPα signaling in xenograft rejection by macrophages (2007) (231)
Treatment of severe autoimmune disease by stem-cell transplantation (2005) (226)
Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen (1990) (225)
Tolerization of Anti–Galα1-3Gal Natural Antibody–forming B Cells by Induction of Mixed Chimerism (1998) (204)
Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. (1998) (202)
Skin graft tolerance across a discordant xenogeneic barrier (1996) (196)
Mixed chimerism and tolerance without whole body irradiation in a large animal model. (2000) (194)
An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues (2006) (194)
CD154 Blockade for Induction of Mixed Chimerism and Prolonged Renal Allograft Survival in Nonhuman Primates (2004) (190)
The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. (2003) (190)
Unusual T cell populations in adult murine bone marrow. Prevalence of CD3+CD4-CD8- and alpha beta TCR+NK1.1+ cells. (1990) (185)
High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. (2000) (185)
Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen. (1999) (181)
Mechanisms of transplant tolerance induction using costimulatory blockade. (2002) (178)
Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance. (1996) (177)
Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen. (1998) (176)
Mixed allogeneic chimerism as an approach to transplantation tolerance. (1988) (173)
Generation and persistence of human tissue-resident memory T cells in lung transplantation (2019) (168)
Hematopoietic Stem Cell Quiescence Maintained by p 21 cip 1 / waf 1 (167)
Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow. (1994) (165)
Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients (2015) (165)
The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. (2007) (163)
Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. (2007) (155)
Mixed chimerism as an approach for the induction of transplantation tolerance. (1999) (148)
Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance. (1992) (145)
Long-Term Follow-Up of Recipients of Combined Human Leukocyte Antigen-Matched Bone Marrow and Kidney Transplantation for Multiple Myeloma With End-Stage Renal Disease (2011) (145)
Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720. (2003) (141)
Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation. (2003) (140)
Peritoneal Cavity B Cells Are Precursors of Splenic IgM Natural Antibody-Producing Cells 1 (2003) (139)
Mixed chimerism induced without lethal conditioning prevents T cell- and anti-Gal alpha 1,3Gal-mediated graft rejection. (1999) (138)
Interleukin-12 inhibits murine graft-versus-host disease. (1995) (137)
Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation. (1996) (129)
Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance. (1999) (129)
Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death1 (2001) (125)
Tolerance induction in clinical transplantation. (2004) (123)
Mixed chimerism and transplantation tolerance. (2001) (123)
Interleukin 2 prevents graft-versus-host disease while preserving the graft-versus-leukemia effect of allogeneic T cells. (1990) (122)
Emerging concepts in haematopoietic cell transplantation (2012) (121)
Mac-1-Negative B-1b Phenotype of Natural Antibody-Producing Cells, Including Those Responding to Galα1,3Gal Epitopes in α1,3-Galactosyltransferase-Deficient Mice1 (2000) (120)
Graft-versus-host-related immunosuppression is induced in mixed chimeras by alloresponses against either host or donor lymphohematopoietic cells (1988) (120)
IL-2 reduces graft-versus-host disease and preserves a graft-versus-leukemia effect by selectively inhibiting CD4+ T cell activity. (1993) (119)
Depletion of CD8 Memory T Cells for Induction of Tolerance of a Previously Transplanted Kidney Allograft (2007) (117)
Dissociating graft-vs-host disease from the graft-vs-leukemia effect of allogeneic T cells: the potential role of IL-2. (1992) (116)
Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation (1993) (115)
Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies. (2003) (115)
Outcomes of Recipients of Both Bone Marrow and Solid Organ Transplants: A Review (1998) (114)
Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells. (2004) (114)
Interleukin-12 preserves the graft-versus-leukemia effect of allogeneic CD8 T cells while inhibiting CD4-dependent graft-versus-host disease in mice. (1997) (114)
Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. (2007) (111)
Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. (2008) (111)
Xenotransplantation: immunological hurdles and progress toward tolerance (2014) (110)
Specific tolerance across a discordant xenogeneic transplantation barrier. (1994) (109)
A Model for Personalized in Vivo Analysis of Human Immune Responsiveness (2012) (108)
Mechanisms of Donor‐Specific Tolerance in Recipients of Haploidentical Combined Bone Marrow/Kidney Transplantation (2011) (108)
Induction of tolerance through mixed chimerism. (2014) (106)
Position paper of the Ethics Committee of the International Xenotransplantation Association. (2004) (105)
In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment (1990) (103)
Host MHC class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions. (2006) (102)
Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene. (1993) (101)
Natural killer cells and their role in graft rejection. (1998) (98)
Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity. (2004) (95)
Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects. (1994) (93)
Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells. (2002) (93)
CD4 T Cell-Mediated Alloresistance to Fully MHC-Mismatched Allogeneic Bone Marrow Engraftment Is Dependent on CD40-CD40 Ligand Interactions, and Lasting T Cell Tolerance Is Induced by Bone Marrow Transplantation with Initial Blockade of this Pathway1 (2001) (90)
Natural killer cells weakly resist engraftment of allogeneic, long-term, multilineage-repopulating hematopoietic stem cells. (1996) (88)
Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-gamma. (2003) (87)
Position Paper of the Ethics Committee of the International Xenotransplantation Association (2003) (87)
Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome (2016) (86)
Antiviral T cell competence and restriction specificity of mixed allogeneic (P1 + P2----P1) irradiation chimeras. (1989) (86)
Chimerism and central tolerance. (1996) (84)
Anti‐tumour response despite loss of donor chimaerism in patients treated with non‐myeloablative conditioning and allogeneic stem cell transplantation (2005) (84)
Results of Gal‐Knockout Porcine Thymokidney Xenografts (2009) (82)
Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. (2004) (82)
Transplanting organs from pigs to humans (2019) (81)
Interleukin-12 inhibits graft-versus-host disease through an Fas-mediated mechanism associated with alterations in donor T-cell activation and expansion. (1998) (81)
Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC. (1999) (81)
Immune restoration by fetal pig thymus grafts in T cell-depleted, thymectomized mice. (1997) (81)
Tolerance, Mixed Chimerism, and Chronic Transplant Arteriopathy1 2 (2001) (81)
Immuno-intervention for the induction of transplantation tolerance through mixed chimerism. (2011) (80)
Mechanism of protection from graft-vs-host disease in murine mixed allogeneic chimeras. I. Development of a null cell population suppressive of cell-mediated lympholysis responses and derived from the syngeneic bone marrow component. (1988) (80)
Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation. (1996) (79)
Early regulation of CD8 T cell alloreactivity by CD4+CD25– T cells in recipients of anti‐CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor‐reactive CD8+ T cells, precluding a role for sustained regulation (2005) (79)
Roles of Deletion and Regulation in Creating Mixed Chimerism and Allograft Tolerance Using a Nonlymphoablative Irradiation-Free Protocol (2005) (79)
Longitudinal Studies of a B Cell–Derived Signature of Tolerance in Renal Transplant Recipients (2015) (79)
Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. (2006) (78)
Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. evidence for pig-specific T-cell unresponsiveness1 (2003) (77)
Mechanisms Involved in the Establishment of Tolerance Through Costimulatory Blockade and BMT: Lack of Requirement for CD40L‐Mediated Signaling for Tolerance or Deletion of Donor‐reactive CD4+ Cells (2001) (77)
Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism1 (2003) (76)
Tolerance in mixed chimerism - a role for regulatory cells? (2004) (74)
Immune tolerance: mechanisms and application in clinical transplantation (2007) (74)
OX40- and CD27-Mediated Costimulation Synergizes with Anti–PD-L1 Blockade by Forcing Exhausted CD8+ T Cells To Exit Quiescence (2015) (73)
HUMORAL TOLERANCE IN XENOGENEIC BMT RECIPIENTS CONDITIONED BY A NONMYELOABLATIVE REGIMEN (1992) (71)
Alloimmune T cells in transplantation (2017) (70)
Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts (2011) (69)
Bone marrow transplantation as a means of inducing tolerance. (1990) (68)
Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway. (2008) (68)
Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement (2016) (67)
Earlier Low‐Dose TBI or DST Overcomes CD8+ T‐Cell‐Mediated Alloresistance to Allogeneic Marrow in Recipients of Anti‐CD40L (2004) (67)
NK Cell Tolerance in Mixed Allogeneic Chimeras1 (2003) (66)
Clinical experience with mixed chimerism to induce transplantation tolerance (2008) (66)
T Cell And B Cell Tolerance To Galα1,3gal-expressing Heart Xenografts Is Achieved In α1,3-galactosyltransferase-deficient Mice By Nonmyeloablative Induction Of Mixed Chimerism1 (2001) (66)
Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD. (1988) (65)
Positive and negative selection of functional mouse CD4 cells by porcine MHC in pig thymus grafts. (1997) (64)
THE IMPORTANCE OF NONIMMUNE FACTORS IN RECONSTITUTION BY DISCORDANT XENOGENEIC HEMATOPOIETIC CELLS1,2 (1994) (63)
Induction of stable long-term mixed hematopoietic chimerism following nonmyeloablative conditioning with T cell-depleting antibodies, cyclophosphamide, and thymic irradiation leads to donor-specific in vitro and in vivo tolerance. (2001) (63)
Hematopoietic cell transplantation for tolerance induction: animal models to clinical trials. (2009) (62)
Lineage‐Negative Side‐Population (SP) Cells with Restricted Hematopoietic Capacity Circulate in Normal Human Adult Blood: Immunophenotypic and Functional Characterization (2002) (62)
In vitro and in vivo analysis of bone marrow-derived CD3+, CD4-, CD8-, NK1.1+ cell lines. (1990) (62)
Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation. (2001) (61)
Mixed Chimerism, Lymphocyte Recovery, and Evidence for Early Donor-Specific Unresponsiveness in Patients Receiving Combined Kidney and Bone Marrow Transplantation to Induce Tolerance (2010) (61)
Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants. (2003) (60)
Mechanisms of Mixed Chimerism-Based Transplant Tolerance. (2017) (58)
Elimination of Porcine Hemopoietic Cells by Macrophages in Mice1 (2002) (57)
Both γδ T Cells and NK Cells Inhibit the Engraftment of Xenogeneic Rat Bone Marrow Cells and the Induction of Xenograft Tolerance in Mice1 (2001) (57)
Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation. (2010) (56)
β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells (2017) (56)
Effect of Ex Vivo–Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques (2017) (56)
IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host-disease. (1994) (55)
Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. (2002) (55)
Type 1 diabetes induction in humanized mice (2017) (55)
B‐Cell Immunity in the Context of T‐Cell Tolerance after Combined Kidney and Bone Marrow Transplantation in Humans (2009) (55)
Bone marrow chimerism and transplantation tolerance. (1997) (54)
Mechanisms of the Antitumor Responses and Host-versus-Graft Reactions Induced by Recipient Leukocyte Infusions in Mixed Chimeras Prepared with Nonmyeloablative Conditioning: A Critical Role for Recipient CD4+ T Cells and Recipient Leukocyte Infusion-Derived IFN-γ-Producing CD8+ T Cells1 (2005) (54)
Human Natural Regulatory T Cell Development, Suppressive Function, and Postthymic Maturation in a Humanized Mouse Model (2011) (53)
Cheng, T. et al. Hematopoietic stem cell quiescence maintained by 21cip1/waf1. Science 287, 1804-1808 (2000) (53)
Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine. (2007) (52)
Tolerization of Galα1,3Gal‐reactive B cells in pre‐sensitized α1,3‐galactosyltransferase‐deficient mice by nonmyeloablative induction of mixed chimerism (2001) (52)
Specific unresponsiveness to a retrovirally-transferred class I antigen is controlled through the helper pathway. (1995) (52)
T cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts is achieved in alpha1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism. (2001) (52)
Effects of T cell depletion in radiation bone marrow chimeras. III. Characterization of allogeneic bone marrow cell populations that increase allogeneic chimerism independently of graft-vs-host disease in mixed marrow recipients. (1989) (52)
Tolerance and xenograft survival (1995) (51)
Quantifying size and diversity of the human T cell alloresponse. (2018) (51)
Homeostatic Expansion and Phenotypic Conversion of Human T Cells Depend on Peripheral Interactions with APCs (2010) (51)
Maturation of human monocyte-derived dendritic cells (MoDCs) in the presence of prostaglandin E2 optimizes CD4 and CD8 T cell-mediated responses to protein antigens: role of PGE2 in chemokine and cytokine expression by MoDCs. (2005) (51)
Role of intrathymic rat class II+ cells in maintaining deletional tolerance in xenogeneic rat-->mouse bone marrow chimeras. (1998) (50)
Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury. (2009) (49)
Dose and timing of interleukin (IL)-12 and timing and type of total-body irradiation: effects on graft-vs.-host disease inhibition and toxicity of exogenous IL-12 in murine bone marrow transplant recipients. (1999) (48)
Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro. (2019) (48)
Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors (47)
Short-Term Immunosuppression Facilitates Induction of Mixed Chimerism and Tolerance after Bone Marrow Transplantation without Cytoreductive Conditioning (2005) (47)
Thymic transplantation across an MHC class I barrier in swine. (1999) (47)
An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation. (2007) (47)
Cross-species interaction of porcine and human integrins with their respective ligands: implications for xenogeneic tolerance induction. (1998) (46)
Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier. (2002) (46)
CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors. (2008) (46)
Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers. (2000) (46)
Early expansion of donor-specific Tregs in tolerant kidney transplant recipients. (2018) (45)
Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation. (2003) (45)
Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12–14, 2018 (2019) (45)
Efficacy of adhesive interactions in pig-to-human xenotransplantation. (1999) (44)
Effects of T cell depletion in radiation bone marrow chimeras. II. Requirement for allogeneic T cells in the reconstituting bone marrow inoculum for subsequent resistance to breaking of tolerance (1988) (43)
Mechanism of tolerance in mixed xenogeneic chimeras prepared with a nonmyeloablative conditioning regimen. (1994) (43)
Mechanism of protection from graft-versus-host disease mortality by IL-2. III. Early reductions in donor T cell subsets and expansion of a CD3+CD4-CD8- cell population. (1992) (43)
Mixed chimerism. (2001) (43)
Separate regulation of peripheral hematopoietic and thymic engraftment. (1998) (42)
Macrochimerism in Intestinal Transplantation: Association With Lower Rejection Rates and Multivisceral Transplants, Without GVHD (2015) (42)
The fate of donor T-cell receptor transgenic T cells with known host antigen specificity in a graft-versus-host disease model. (1999) (42)
Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance. (2001) (42)
Altered expression of Ly-49 receptors on NK cells developing in mixed allogeneic bone marrow chimeras. (1998) (41)
Adoption with Contact: A Study of Adoptive Parents and the Impact of Continuing Contact with Families of Origin (2000) (41)
Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice. (2004) (41)
Chapter 1: Key ethical requirements and progress toward the definition of an international regulatory framework (2009) (41)
LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. (2011) (40)
Hematopoietic cell transplantation for the induction of allo- and xenotolerance. (1996) (40)
Vascularized Thymic Lobe Transplantation in a Pig-to-Baboon Model: A Novel Strategy for Xenogeneic Tolerance Induction and T-cell Reconstitution (2005) (40)
Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor. (2001) (39)
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization (2018) (39)
Xenotransplantation from pig to cynomolgus monkey: the potential for overcoming xenograft rejection through induction of chimerism. (1994) (39)
Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire. (2019) (39)
Host marrow has a competitive advantage that limits donor hematopoietic repopulation in mixed xenogeneic chimeras (1996) (38)
Clonal deletion as a mechanism of transplantation tolerance. (1996) (37)
Natural antibodies against bone marrow cells of a concordant xenogeneic species. (1991) (37)
Pig MHC mediates positive selection of mouse CD4+ T cells with a mouse MHC-restricted TCR in pig thymus grafts. (1998) (37)
A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo. (2010) (37)
A novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT. (2000) (37)
Posttransplant Hemophagocytic Lymphohistiocytosis Driven by Myeloid Cytokines and Vicious Cycles of T-Cell and Macrophage Activation in Humanized Mice (2019) (36)
Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney–Bone Marrow Transplantation to Induce Transplantation Tolerance (2017) (36)
Mixed Hematopoietic Chimerism for the Simultaneous Induction of T and B Cell Tolerance (2005) (35)
Human–porcine receptor–ligand compatibility within the immune system: relevance for xenotransplantation (1999) (35)
Hypercholesterolemia induces T cell expansion in humanized immune mice (2018) (35)
Graft-versus-leukemia effect using mixed allogeneic bone marrow transplantation. (1989) (35)
Decay-Accelerating Factor Prevents Acute Humoral Rejection Induced by Low Levels of Anti-αGal Natural Antibodies (2006) (35)
The Host Environment Regulates the Function of CD8+ Graft-versus-Host-Reactive Effector Cells1 (2008) (35)
INHIBITION OF GRAFT‐VERSUS‐HOST DISEASE BY INTERLEUKIN‐2 TREATMENT IS ASSOCIATED WITH ALTERED CYTOKINE PRODUCTION BY EXPANDED GRAFT‐VERSUS‐HOST‐REACTIVE CD4+ HELPER CELLS (1995) (35)
Discordant xenogeneic neonatal thymic transplantation can induce donor-specific tolerance. (1997) (35)
CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance. (2009) (35)
Evidence for nonimmune mechanisms in the loss of hematopoietic chimerism in rat→mouse mixed xenogeneic chimeras (1995) (35)
CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenase. (2007) (34)
Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool. (2019) (34)
Enhanced CD4 reconstitution by grafting neonatal porcine tissue in alternative locations is associated with donor-specific tolerance and suppression of preexisting xenoreactive T cells. (2001) (34)
Xenograft Tolerance and Immune Function of Human T Cells Developing in Pig Thymus Xenografts (2014) (33)
Role of peripheral clonal deletion in tolerance induction with bone marrow transplantation and costimulatory blockade. (1999) (32)
Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance (2002) (32)
Engraftment of rat bone marrow and its role in negative selection of murine T cells in mice conditioned with a modified nonmyeloablative regimen (1994) (32)
Donor‐specific growth factors promote swine hematopoiesis in severe combined immune deficient mice (1996) (32)
Comparison of outcomes after transplantation of peripheral blood stem cells versus bone marrow following an identical nonmyeloablative conditioning regimen (2007) (32)
Translational studies in hematopoietic cell transplantation: treatment of hematologic malignancies as a stepping stone to tolerance induction. (2011) (32)
Mixed hematopoietic chimerism and transplantation tolerance (1997) (32)
Long-term Survival of Transplanted Allogeneic Cells Engineered to Express a T Cell Chemorepellent (2007) (32)
Natural antibodies can inhibit bone marrow engraftment in the rat----mouse species combination. (1991) (32)
Lack of Role for CsA‐Sensitive or Fas Pathways in the Tolerization of CD4 T Cells Via BMT and Anti‐CD40L (2003) (32)
Intra‐bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival (2019) (32)
Achieving alloengraftment without graft-versus-host disease: approaches using mixed allogeneic bone marrow transplantation. (1988) (31)
Induction of tolerance. (2004) (31)
Rapid Deletional Peripheral CD8 T Cell Tolerance Induced by Allogeneic Bone Marrow: Role of Donor Class II MHC and B Cells1 (2008) (31)
Immunobiology of transplantation 1 (1996) (31)
Natural suppressor cells in spleens of irradiated, bone marrow-reconstituted mice and normal bone marrow: lack of Sca-1 expression and enrichment by depletion of Mac1-positive cells. (1990) (31)
Manipulating the immune system for anti‐tumor responses and transplant tolerance via mixed hematopoietic chimerism (2008) (30)
Mechanisms of tolerance induced via mixed chimerism. (2007) (30)
Alloreactive CD8 T Cell Tolerance Requires Recipient B Cells, Dendritic Cells, and MHC Class II1 (2008) (30)
GalT‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels (2018) (30)
The role of interleukin-12 in preserving the graft-versus-leukemia effect of allogeneic CD8 T cells independently of GVHD. (1999) (30)
International Human Xenotransplantation Inventory (2010) (30)
Differing Mechanisms of Early and Late B Cell Hyporesponsiveness Induced by Mixed Chimerism (2005) (29)
Occurrence of specific humoral non‐responsiveness to swine antigens following administration of GalT‐KO bone marrow to baboons (2010) (29)
Monitoring Antidonor Alloantibodies as a Predictive Assay for Renal Allograft Tolerance/Long-term Observations in Nonhuman Primates (2006) (29)
Induction of Human T‐Cell Tolerance to Pig Xenoantigens via Thymus Transplantation in Mice with an Established Human Immune System (2009) (28)
Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of β-Cell Replacement. (2016) (28)
B-cell reconstitution and xenoreactive anti-pig natural antibody production in severe combined immunodeficient mice reconstituted with immunocompetent B cells from varying sources. (1998) (27)
Interleukin-12 prevents severe acute graft-versus-host disease (GVHD) and GVHD-associated immune dysfunction in a fully major histocompatibility complex haplotype-mismatched murine bone marrow transplantation model. (1997) (27)
Tolerance Induction for Xenotransplantation (1997) (27)
Deletion of donor‐reactive T cell clones after human liver transplant (2020) (27)
In vivo T-cell depletion enhances production of anti-GALalpha1,3GAL natural antibodies in alpha1,3-galactosyltransferase-deficient mice. (2000) (26)
Clinical relevance of recipient leukocyte infusion as antitumor therapy following nonmyeloablative allogeneic hematopoietic cell transplantation. (2006) (26)
Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sites. (2004) (26)
Non-myeloblative induction of mixed hematopoietic chimerism: application to transplantation tolerance and hematologic malignancies in experimental and clinical studies. (2002) (25)
HIGHLY DISPARATE XENOGENEIC SKIN GRAFT TOLERANCE INDUCTION BY FETAL PIG THYMUS IN THYMECTOMIZED MICE: Conditioning Requirements and the Role of Coimplantation of Fetal Pig Liver1 (2001) (25)
Global Unresponsiveness as a Mechanism of Natural Killer Cell Tolerance in Mixed Xenogeneic Chimeras (2007) (25)
Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity1 (2003) (25)
Xenogeneic thymus transplantation in a pig-to-baboon model1 (2003) (24)
Xenograft Tolerance (1994) (24)
Levels of Ly-49 receptor expression are determined by the frequency of interactions with MHC ligands: evidence against receptor calibration to a "useful" level. (1999) (24)
The mechanism of specific prolongation of class I‐mismatched skin grafts induced by retroviral gene therapy (1997) (24)
Tolerization of Gal alpha 1,3Gal-reactive B cells in pre-sensitized alpha 1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism. (2001) (24)
Novel approaches to the control of graft versus host disease. (1993) (24)
Invariant NKT Cells Are Required for Antitumor Responses Induced by Host-Versus-Graft Responses (2010) (23)
Tolerance in xenotransplantation (2007) (23)
Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy. (2009) (23)
Protection from graft-versus-host disease in fully allogeneic chimeras by prior administration of T cell-depleted syngeneic bone marrow. (1988) (22)
NK cell recovery, chimerism, function, and recognition in recipients of haploidentical hematopoietic cell transplantation following nonmyeloablative conditioning using a humanized anti-CD2 mAb, Medi-507. (2003) (22)
Xenotransplantation from pig to cynomolgus monkey: approach toward tolerance induction. (1993) (22)
Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier (2000) (21)
Both gamma delta T cells and NK cells inhibit the engraftment of xenogeneic rat bone marrow cells and the induction of xenograft tolerance in mice. (2001) (21)
Immune evasion by chimeric trachea. (2010) (21)
B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells. (2007) (21)
Comparison of Human T Cell Repertoire Generated in Xenogeneic Porcine and Human Thymus Grafts (2008) (21)
Abnormal Regulatory and Effector T Cell Function Predispose to Autoimmunity following Xenogeneic Thymic Transplantation1 (2008) (20)
Clinical trial of islet xenotransplantation in Mexico (2006) (20)
The induction of specific pig skin graft tolerance by grafting with neonatal pig thymus in thymectomized mice. (2000) (20)
THE MECHANISM OF IL‐2-MEDIATED PROTECTION AGAINST GVHD IN MICE: II. Protection Occurs Independently of NK/LAK Cells1 (1992) (20)
A New Window into the Human Alloresponse (2016) (20)
Distinct Requirements for Achievement of Allotolerance Versus Reversal of Autoimmunity via Nonmyeloablative Mixed Chimerism Induction in NOD Mice (2010) (20)
Transplantation: Bone marrow and solid organ transplantation start to converge (1999) (19)
Modeling Human Leukemia Immunotherapy in Humanized Mice (2016) (19)
Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation. (2021) (19)
Function of porcine adhesion molecules in a human marrow microenvironment. (1998) (19)
T Cell Subsets Resisting Induction of Mixed Chimerism Across Various Histocompatibility Barriers (1993) (19)
Cross-species compatibility of intercellular adhesion molecule-1 (CD54) with its ligands. (2000) (18)
MHC Class I Expression by Donor Hematopoietic Stem Cells Is Required to Prevent NK Cell Attack in Allogeneic, but Not Syngeneic Recipient Mice (2015) (18)
Commentary: World Health Assembly resolution 57.18 on xenotransplantation. (2005) (18)
Role of indirect allo- and autoreactivity in anti-tumor responses induced by recipient leukocyte infusions (RLI) in mixed chimeras prepared with nonmyeloablative conditioning. (2006) (18)
The Fourth International Workshop on Clinical Transplant Tolerance (2020) (18)
Tolerance to discordant xenografts. I. Sharing of human natural antibody determinants on miniature swine bone marrow cells and endothelial cells. (1994) (17)
Mixed bone marrow chimerism as a treatment for autoimmune diabetes. (2001) (17)
Xenotransplantation of pig islets into Mexican children: were the fundamental ethical requirements to proceed with such a study really met? (2006) (17)
Siplizumab selectively depletes effector memory T cells and promotes a relative expansion of alloreactive regulatory T cells in vitro (2020) (17)
Induction of specific tolerance to MHC-disparate allografts through genetic engineering. (1993) (17)
Mixed chimerism for the induction of tolerance: potential applicability in clinical composite tissue grafting. (1998) (17)
Transgenic expression of human CD47 reduces phagocytosis of porcine endothelial cells and podocytes by baboon and human macrophages (2019) (17)
The critical role of mouse CD4+ cells in the rejection of highly disparate xenogeneic pig thymus grafts (2000) (17)
Role of antibody-independent complement activation in rejection of porcine bone marrow cells in mice. (2000) (16)
Twenty Year Follow Up of Histocompatibility Leukocyte Antigen-Matched Kidney and Bone Marrow Co-Transplantation for Multiple Myeloma with End Stage Renal Disease: Lessons Learned. (2019) (15)
Genetic analysis of the anti-leukemic effect of mixed allogeneic bone marrow transplantation. (1989) (15)
Maturation and function of mouse T-cells with a transgenic TCR positively selected by highly disparate xenogeneic porcine MHC. (2001) (15)
MECHANISMS OF SUPPRESSION IN MIXED ALLOGENEIC CHIMERAS (1988) (15)
Characterization of Anti-Gal Antibody-Producing Cells of Baboons and Humans (2006) (15)
Murine Mobilized Peripheral Blood Stem Cells Have a Lower Capacity than Bone Marrow to Induce Mixed Chimerism and Tolerance (2008) (15)
IL-2-induced GVHD protection is not inhibited by cyclosporine and is maximal when IL-2 is given over a 25 h period beginning on the day following bone marrow transplantation. (1995) (15)
Mechanisms of Transplantation Tolerance in Animals and Humans (2009) (15)
Stem cell activity of porcine c-kit+ hematopoietic cells. (2003) (14)
Impact of Mixed Xenogeneic Porcine Hematopoietic Chimerism on Human NK Cell Recognition in a Humanized Mouse Model (2017) (14)
Human organ and tissue transplantation. Commentary (2005) (14)
Xenogeneic Tolerance Through Hematopoietic Cell and Thymic Transplantation (1997) (14)
American Society of Transplantation Symposium on B Cells in Transplantation: Harnessing Humoral Immunity from Rodent Models to Clinical Practice (2007) (14)
Immune tolerance in recipients of combined haploidentical bone marrow and kidney transplantation (2015) (14)
Central Tolerance to Myogenic Cell Transplants Does Not Include Muscle Neoantigens (2008) (14)
Long-term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation (2017) (14)
Strain Dependence of Interleukin‐2-Induced Graft‐Versus-Host Disease Protection: Evidence That Interleukin‐2 Inhibits Selected CD4 Functions (1994) (13)
Xenogeneic thymic transplantation in a pig-to-nonhuman primate model. (1999) (13)
HSC extrinsic sex-related and intrinsic autoimmune disease-related human B-cell variation is recapitulated in humanized mice. (2017) (13)
Recipient Dendritic Cells, But Not B Cells, Are Required Antigen‐Presenting Cells for Peripheral Alloreactive CD8+ T‐Cell Tolerance (2010) (13)
B‐Cell‐Dependent Memory T Cells Impede Nonmyeloablative Mixed Chimerism Induction in Presensitized Mice (2011) (13)
Mechanism of tolerance following class II gene transduction of autologous swine bone marrow. (1997) (13)
Use of CD9 expression to enrich for porcine hematopoietic progenitors. (2002) (13)
Decreased graft-versus-host disease after haplotype mismatched bone marrow allografts in miniature swine following interleukin-2 treatment (2000) (13)
Guidelines for xenotransplantation. (2003) (12)
Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning. (2004) (12)
Restimulation After Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells (2015) (12)
B cell tolerance to xenoantigens (2003) (12)
Anti-CD40L Monoclonal Antibodies Can Replace Anti-CD4 Monoclonal Antibodies for the Nonmyeloablative Induction of Mixed Xenogeneic Chimerism (2006) (12)
Fetal porcine thymus engraftment, survival and CD4 reconstitution in αGal‐KO mice is impaired in the presence of high levels of antibodies against αGal (2003) (12)
Long-Term Survival of Xenogeneic Heart Grafts Achieved by Costimulatory Blockade and Transient Mixed Chimerism (2006) (12)
Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical related allogeneic bone marrow transplant. (2002) (12)
Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons (2020) (11)
Immune monitoring of transplant patients in transient mixed chimerism tolerance trials. (2017) (11)
Engraftment of discordant xenogeneic swine bone marrow cells in immunodeficient mice (1997) (11)
Mixed swine/human long-term bone marrow cultures. (1994) (11)
Humoral tolerance in mixed xenogeneic chimeras prepared by a nonmyeloablative conditioning regimen. (1991) (11)
Induction of mixed chimerism through transplantation of CD45-congenic mobilized peripheral blood stem cells after nonmyeloablative irradiation. (2006) (11)
Cellular modulation of acute graft-vs.-host disease. (1997) (10)
Prospective Tracking of Donor-Reactive T-Cell Clones in the Circulation and Rejecting Human Kidney Allografts (2021) (10)
Tolerance induction using autologous bone marrow modified with an allogeneic class I MHC gene. (1993) (10)
Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY 720 (2003) (10)
World Health Organization resolution on xenotransplantation (2004) (10)
Characterization, biology, and expansion of regulatory T cells in the Cynomolgus macaque for preclinical studies (2019) (10)
T cell repertoire analysis suggests a prominent bystander response in human cardiac allograft vasculopathy (2020) (9)
Expression and purification of soluble murine CD40L monomers and polymers in yeast Pichia pastoris. (2011) (9)
Response to Valdes‐Gonzalez ‘‘Clinical trial of islet xenotransplantation in Mexico’’ (2007) (9)
Role of VLA-4 and VLA-5 in ex vivo maintenance of human and pig hematopoiesis in human stroma-supported long-term cultures. (2005) (9)
Advances in transplantation. (2011) (9)
GalT-KO pigs: is the cup half empty or half full? (2007) (9)
Murine CD4 T Cells Selected in a Highly Disparate Xenogeneic Porcine Thymus Graft Do Not Show Rapid Decay in the Absence of Selecting MHC in the Periphery1 (2002) (9)
How Safe Are Universal Pluripotent Stem Cells? (2020) (9)
IXA Honorary Member Lecture, 2017: The long and winding road to tolerance (2018) (9)
Alloresistance to K locus class I-mismatched bone marrow engraftment is mediated entirely by CD4+ and CD8+ T cells. (1996) (9)
Nonalloreactive T Cells Prevent Donor Lymphocyte Infusion–Induced Graft-versus-Host Disease by Controlling Microbial Stimuli (2012) (9)
Porcine mononuclear cells adhere to human fibronectin independently of very late antigen‐5: implications for donor‐specific tolerance induction in xenotransplantation (2002) (9)
Functionally and phenotypically mature mouse CD8+ T cells develop in porcine thymus grafts in mice (1998) (9)
Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus (2020) (8)
Achievement of sustained remissions despite loss of donor chimerism in patients with chemotherapy-refractory non-Hodgkins lymphoma treated with nonmyeloablative conditioning and allogeneic stem cell transplantation (2001) (8)
Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice (2019) (8)
Porcine hematopoiesis on primate stroma in long-term cultures: enhanced growth with neutralizing tumor necrosis factor-&agr; and tumor growth factor-&bgr; antibodies (2002) (8)
International inventory of xenotransplantation practices in humans (2006) (8)
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation (2021) (8)
Multiple mixed chimeras: reconstitution of lethally irradiated mice with syngeneic plus allogeneic bone marrow from multiple strains. (1989) (8)
Pharmacokinetic and pharmacodynamic study of a clinically effective anti‐CD2 monoclonal antibody (2020) (8)
Alloengraftment in IL-2-treated mice. (1992) (7)
Use of skin grafting to demonstrate tolerance before kidney transplantation without immunosuppression in the recipient of a previous bone marrow transplant. (2005) (7)
Experience with porcine thymic transplantation in baboons. (2000) (7)
Effects of xenogeneic thymic transplantation in baboons. (2001) (7)
Allospecific Rejection of MHC Class I‐Deficient Bone Marrow by CD8 T Cells (2014) (7)
Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: relevance for a gene therapy approach to tolerance induction. (1996) (7)
Hematopoietic chimerism and tolerance of T cells, B cells, and NK cells. (1998) (7)
T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction. (2005) (7)
Human Stem Cell-Derived Thymic Epithelial Cells Enhance Human T Cell Development in a Xenogeneic Thymus. (2021) (7)
2007 IXA Presidential Address. Progress toward an ideal source animal: opportunities and challenges in a changing world (2008) (6)
T Cells from Presensitized Donors Fail to Cause Graft-versus-Host Disease in a Pig-to-Mouse Xenotransplantation Model (2004) (6)
Induction of mixed vs full chimerism to potentiate GVL effects after bone-marrow transplantation. (2005) (6)
Transplantation tolerance in nonhuman primates and humans (2019) (6)
In Vitro and In Vivo Effects of Recombinant Human Interleukin‐2 in Naive Miniature Swine (1992) (6)
Rapid Functional Decline of Activated and Memory Graft-versus-Host–Reactive T Cells Encountering Host Antigens in the Absence of Inflammation (2015) (6)
Faculty Opinions recommendation of Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen. (2002) (6)
Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction. (2007) (6)
(2) Cotransplantation of vascularized thymus and kidney from GalT‐KO pigs to baboons (2007) (6)
Reduction of anti-Galα1–3Gal natural antibodies in sera of α1,3-galactosyltransferase-deficient mice receiving gal-positive bone marrow transplantation (1999) (6)
Transient-mixed Chimerism With Nonmyeloablative Conditioning Does Not Induce Liver Allograft Tolerance in Nonhuman Primates. (2020) (6)
Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives (2022) (6)
Repopulation of mouse CD4 cells in BALB/c nude mice receiving fetal pig thymus/liver grafts. (1997) (6)
Safety and pharmacodynamics of anti‐CD2 monoclonal antibody treatment in cynomolgus macaques – an experimental study (2020) (6)
Reduced positive selection of a human TCR in a swine thymus using a humanized mouse model for xenotolerance induction (2019) (5)
A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons. (2000) (5)
Reply to 'Critics slam Russian trial to test pig pancreas for diabetes' (2007) (5)
International cooperation on xenotransplantation (2004) (5)
Preparation of hybrid porcine thymus containing non‐human primate thymic epithelial cells in miniature swine (2019) (5)
Host thymectomy and cyclosporine lead to unstable skin graft tolerance after class I mismatched allogeneic neonatal thymic transplantation in mice. (2005) (5)
Integrated analysis toolset for defining and tracking alloreactive T-cell clones after human solid organ and hematopoietic stem cell transplantation (2021) (5)
Effect of natural killer cell depletion on long-term multilineage allogeneic bone marrow engraftment. (1993) (5)
Clinical outcomes of late rather than early full-donor chimerism in patients with advanced lymphomas receiving nonmyeloablative allogeneic hematopoietic SCT (2008) (5)
Role of the thymus in donor specific hyporesponsiveness induced by retroviral transduction of bone marrow using an MHC class I gene. (1997) (5)
Retroviral vectors for long-term expression of allogeneic major histocompatibility complex transduced into syngeneic bone marrow cells. (1995) (5)
Novel H-shunt Venovenous Bypass for Liver Transplantation in Cynomolgus Macaques. (2017) (5)
Dynamics of B Cell Recovery In Kidney/Bone Marrow Transplant Recipients (2017) (4)
Resistance to monoclonal antibody-induced CD8+ T-cell depletion in thymectomized MHC class II-deficient mice. (1997) (4)
CD40L‐stimulated B cells for ex‐vivo expansion of polyspecific non‐human primate regulatory T cells for translational studies (2020) (4)
High Throughput Human T Cell Receptor Sequencing: A New Window Into Repertoire Establishment and Alloreactivity (2021) (4)
Clinical strategy for induction of transplantation tolerance through mixed chimerism. (2013) (4)
Protecting the host naturally (2005) (4)
Induction of tolerance to pig antigens in mice grafted with fetal pig thymus/liver grafts. (1994) (4)
Ethics Committee of the International Xenotransplantation Association. Guidelines for xenotransplantation (2003) (4)
The recovery of resistance to alloengraftment following lethal irradiation and administration of T cell-depleted syngeneic bone marrow. (1989) (4)
Treatment of renal-cell cancer by transplantation of allogeneic stem cells. (2001) (4)
Transient Mixed Chimerism With Nonmyeloablative Conditioning Does Not Induce Liver Allograft Tolerance in Nonhuman Primates. (2020) (4)
Selective inhibition of CD4 graft-versus-host activity in IL-2-treated mice. (1993) (4)
Response to ‘Tolerance Versus Immunosuppression: A Perspective’ (2008) (4)
Mixed hematopoietic chimerism and transplantation tolerance: insights from experimental models (1999) (4)
Xenotolerance Through Bone Marrow Transplantation (1991) (4)
Letter to Authors (2006) (3)
Hematopoietic competition limits xenogenic myeloid reconstitution in SCID mice. (1996) (3)
Emerging Concepts of Tissue-resident Memory T Cells in Transplantation. (2021) (3)
Layers of regulation in induction of mixed chimerism by anti-CD40L (2011) (3)
Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice. (2021) (3)
Enhanced porcine hematopoiesis in mice receiving donor-specific interleukin-3. (1996) (3)
Mechanisms of Tolerance (2007) (3)
Mixed xenogeneic porcine chimerism tolerizes human anti‐pig natural antibody‐producing cells in a humanized mouse model (2021) (3)
B cell tolerance and xenotransplantation (2005) (3)
How Safe Are Universal Pluripotent Stem Cells? (2020) (3)
Surgical research review (2004) (3)
Author response to comment on “Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients” (2015) (3)
MECHANISMS OF DONOR-SPECIFIC UNRESPONSIVENESS IN TOLERANT RECIPIENTS OF COMBINED NON-MYELOABLATIVE HLA-MISMATCHED BONE MARROW AND KIDNEY TRANSPLANTATION (2004) (3)
Donor Bone Marrow-Derived T Cells Inhibit GVHD Induced by Donor Lymphocyte Infusion in Established Mixed Allogeneic Hematopoietic Chimeras (2012) (3)
AN UNEXPECTED ROLE FOR CD28 AND LACK OF A ROLE FOR CD40L SIGNALING IN PERIPHERAL DELETION OF DONOR-REACTIVE CD4+ T CELLS AND ESTABLISHMENT OF MIXED CHIMERISM THROUGH COSTIMULATORY BLOCKADE (1999) (3)
Satellite Symposium held in conjunction with the World Transplant Congress, Boston, 2006 (2007) (3)
Impact of CMV Reactivation, Treatment Approaches, and Immune Reconstitution in a Nonmyeloablative Tolerance Induction Protocol in Cynomolgus Macaques (2020) (2)
The first Joint Conference of the Cell Transplant Society (CTS), International Pancreas and Islet Transplant Association (IPITA), and International Xenotransplantation Association (IXA), all sections of The Transplantation Society (TTS), took place in Minneapolis, Minn, USA, from September 15-20, 20 (2008) (2)
O-40: Single-Cell Immune Profiling of Human Intestinal Allografts Reveals Differential Contributions of HvG T-cell Clones in Quiescent vs Chronically Rejecting Allografts (2021) (2)
Transplantation: moving to the next level (2014) (2)
Suppressive activity in recipients of non-T cell-depleted allogeneic bone marrow transplants: role of T cell-depleted syngeneic marrow. (1989) (2)
Porcine stem cell factor facilitates long-lasting porcine hematopoietic engraftment in murine recipients. (2000) (2)
Enforced co-stimulation and co-inhibitory blockade synergise to enhance the functions of exhausted CTL (2011) (2)
Effect of natural antibody on xenogeneic bone marrow engraftment. (1992) (2)
Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high‐dose bone marrow transplantation for the induction of mixed chimerism and tolerance (2002) (2)
Long Term Follow-up of Recipients of Combined HLA-Matched Nonmyeloablative Bone Marrow and Kidney Transplantation for Multiple Myeloma with End-Stage Renal Disease. (2009) (2)
A step closer to effective transplant tolerance? (2012) (2)
The role of atypical T cells and NK cells in inhibiting primary engraftment of xenogeneic donor rat bone marrow cells. (1999) (2)
DEVELOPMENT OF A MIXED CHIMERISM-TOLERANCE INDUCING NONMYELOABLATIVE REGIMEN RELEVANT TO CADAVER DONOR TRANSPLANTATION (2004) (2)
Persistence of donor-derived protein in host myeloid cells after induced rejection of engrafted allogeneic bone marrow cells. (2009) (1)
Developing pig-to-human organ transplants (2022) (1)
PE-2: Dynamic Reconstitution of Recipient Resident Memory T Cell Repertoire after Human Intestinal Transplantation (2021) (1)
TOLERANCE OF RENAL ALLOGRAFTS ACROSS HLA BARRIERS: FOLLOW-UP ON THE FIRST TRIAL AND INITIAL RESULTS OF THE SECOND: 845 (2010) (1)
Role of Graft-derived Graft-versus-Host T cells in Facilitating Multilineage Blood Chimerism after Human Intestinal Transplantation (2018) (1)
Thymic Education of Human T Cells and Regulatory T Cell Development in Humanized Mice (2014) (1)
Long-lasting anti-tumor immunity induced by the rejection of donor hematopoietic cells in mixed bone marrow chimeras (2006) (1)
SUBSTANTIAL DONOR CHIMERISM AND TOLERANCE ACROSS A FULL MHC BARRIER WITHOUT HOST PRE-CONDITIONING (1999) (1)
JAKing up immunosuppression (2003) (1)
SINGLE CELL IMMUNE PROFILING OF HUMAN INTESTINAL ALLOGRAFTS REVEALS HETEROGENEITY AND ALLOREACTIVITY OF RECIPIENT RESIDENT MEMORY T CELLS IN ASSOCIATION WITH GRAFT OUTCOMES (2020) (1)
XENOGENEIC THYMUS TRANSPLANTATION IN A PIG-TO- (2003) (1)
Graft-versus-Host Disease and Graft-versus-Leukemic Effect in Allogeneic Bone Marrow Transplantation: Role of Interferon-{gamma} (2002) (1)
High antigen levels do not preclude B‐cell tolerance induction to α1,3‐Gal via mixed chimerism (2008) (1)
Non-Myeloablative Conditioning with Low-Dose Total Body Irradiation in Place of Cyclophosphamide Induces Mixed Chimerism and Long-Term Immunosuppression Free Allograft Survival without Acute Kidney Injury in HLA Mismatched Kidney Transplantation (2018) (1)
SYNERGISTIC EFFECT OF COSTIMULATORY BLOCKADE AND CYCLOSPORIN TREATMENT IN THE ESTABLISHMENT OF EARLY MIXED HEMATAPOIETIC CHIMERISM.: Abstract# 993 (2000) (1)
High-Yield Monocyte, Macrophage, and Dendritic Cell Differentiation from Induced Pluripotent Stem Cells (2021) (1)
317.2: Immune Profiling of Migrating and Graft-Associated γδ T Cells After Human Intestinal Transplantation Reveals Unique Innate and Adaptive Features (2022) (1)
COMBINED KIDNEY AND BONE MARROW TRANSPLANTATION FOR INDUCTION OF MIXED CHIMERISM AND RENAL ALLOGRAFT TOLERANCE IN HLA MISMATCHED TRANSPLANTATION (2004) (1)
Maintenance of Hematopoietic Stem Cells in a Low Calcium Environment (2018) (1)
Reduction of anti-Gal alpha 1-3Gal natural antibodies in sera of alpha 1,3-galactosyltransferase-deficient mice receiving Gal-positive bone marrow transplantation. (1999) (1)
Induction of Durable Mixed Hematopoietic Chimerism and Immune Tolerance in Monkeys (2015) (1)
Role of Deletion of Donor-Reactive T Cells in Long-Term Human Allograft Tolerance Achieved Via Combined Kidney and Bone Marrow Transplantation (CKBMT).: Abstract# 591 (2014) (1)
T.32. Mechanisms of Donor-Specific Unresponsiveness Following Loss of Chimerism in Recipients of Haploidentical Combined Bone Marrow/Kidney Transplantation (2009) (1)
Porcine thymus supports development of human T cells that are tolerant to porcine xenoantigens. (1999) (1)
American Transplant Congress 2007 Executive and Program Planning Committees and Abstract Review Committees (2007) (1)
HUMAN CD47 EXPRESSION PROTECTS PORCINE CELLS FROM XENOGENEIC HUMAN MACROPHAGE PHAGOCYTOSIS (2006) (1)
Deletion of donor-reactive T cell clones following human liver transplantation (2020) (1)
T1D patient-derived hematopoietic stem cells are programmed to generate Tph, Tfh, and autoimmunity-associated B cell subsets in human immune system mice. (2022) (1)
O-37: Immune Profiling of γδ T Cells Locally and Systemically after Human Intestinal Transplantation Reveals Unique Innate and Adaptive Features (2021) (1)
Mechanism of the anti-GVHD effect of IL-2. I. Protective host-type cell populations are not induced by IL-2 treatment alone. (1991) (1)
Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs (2022) (1)
INDUCTION OF MIXED HEMATOPOIETIC CHIMERISM AND TOLERANCE WITH SUBOPTIMAL RECIPIENT T CELL DEPLETION, 3GY TBI AND ANTI-CD154 OR CTLA4Ig: TOWARD A CLINICAL REGIMEN USEFUL FOR CADAVERIC DONORS (1999) (1)
Outcomes of Patients with Engraftment Syndrome (ES) Following Nonmyeloablative Hematopoietic Stem Cell Transplant (SCT) for Hematologic Malignancy(HM). (2005) (1)
TCR in Pig Thymus Grafts T Cells with a Mouse MHC-Restricted + CD 4 Pig MHC Mediates Positive Selection of Mouse (1998) (1)
HIGH LEVELS OF CYTOTOXIC ANTI-NON GAL PREFORMED NATURAL ANTIBODY DID NOT INDUCE HYPERACUTE REJECTION BUT DID CAUSE EARLY GRAFT LOSS IN A GALT-KO PIG-TO-BABOON THYMOKIDNEY MODEL: 2413 (2010) (1)
Specific Non-Responsiveness to Pig in Baboons Receiving BMT from GalT-KO Pigs. (2006) (1)
Differing Mechanisms for Early Versus Persistent Donor T cell Chimerism in Peripheral Blood of Human Intestinal Transplant Recipients (2017) (1)
Understanding the Role of the Immune System in Improving Tissue Regeneration (2022) (1)
Graft-versus-Host Disease and Graft-versus-Leukemic Effect in Allogeneic Bone Marrow Transplantation Role of Interferon-γ (2002) (1)
ALLODEPLETION BY COMBINED USE OF METHOTREXATE AND FLUDARABINE: 501 (2010) (0)
Faculty Opinions recommendation of Global absence and targeting of protective immune states in severe COVID-19. (2021) (0)
Renal Allograft Tolerance for End-Stage Renal Disease Patients with Hematologic Malignancies (2018) (0)
Resting and Restimulation after Cryopreservation Restores Regulatory T Cell Phenotype and Function.: Abstract# C3037 (2014) (0)
Designer meetings (2002) (0)
Il-2-induced separation of GVHD-promoting and GVL effects of allogeneic cells does not depend on host-versus-graft alloreactivity (1995) (0)
Tolerance Is Induced by Bone Marrow Ligand Interactions , and Lasting T Cell Engraftment Is Dependent on CD 40-CD 40 MHC-Mismatched Allogeneic Bone Marrow CD 4 T Cell-Mediated Alloresistance to Fully (2001) (0)
LONG TERM OBSERVATIONS IN RENAL ALLOGRAFT RECIPIENTS TREATED WITH A CHIMERISM- INDUCING NONMYELOABLATIVE REGIMEN WITH CD154 BLOCKADE (2004) (0)
THE USE OF MOBILIZED PERIPHERAL BLOOD STEM CELLS FOR THE INDUCTION OF MIXED CHIMERISM AND TOLERANCE (2004) (0)
Advances in xenotransplantation: is the Gal knockout pig essential to clinical success? (2007) (0)
OR.26Role of Granzyme B in the Antitumor Effects Induced by Recipient Lymphocyte Infusion in Mixed Bone Marrow Chimeras (2010) (0)
Peripheral Alloantigen Drives Early Dysfunction and Eventual Exhaustion of CTL Following Delayed Donor Leukocyte Infusions. (2008) (0)
Phenotypic and Clonal Analysis of Recipient B cells and Plasma Cells Entering Graft Mucosa Reveals an Association with Rejection and Evolution towards a Resident Memory Phenotype after Human Intestinal Transplantation (2018) (0)
XENOGENEIC THYMIC TRANSPLANTATION IN A PIG-TO-NON-HUMAN-PRIMATE MODEL (1998) (0)
My most interesting cases. (2006) (0)
Class I Barrier in Swine Thymic Transplantation Across an MHC (1999) (0)
Characterization of NK1.1+ CD8 T Cells in Allogeneic Hematopoietic Cell Transplantation Recipients (2008) (0)
Faculty Opinions recommendation of Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation. (2021) (0)
Megadose Bone Marrow and Regulatory T cells for the Induction of Immune Tolerance in Non-Human Primates Through Durable Mixed Hematopoietic Chimerism Across MHC-barriers (2018) (0)
Clonal Expansion of Graft-Versus-Host Reactive CD8+ T Cells Is Dissociated from Full Effector Differentiation Following Delayed DLI. (2007) (0)
Establishment of donor Chimerism Using Allogeneic Bone Marrow with AMP Cell Co-infusion (2017) (0)
Graft-Versus-Host Alloresponses to Treat Nonlymphohematopoietic Tumors: Is There a Solid Approach? (2001) (0)
CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals (2021) (0)
Induction of Tolerance for Long-Term Liver Allograft Survival Without Immunosuppression in Cynomolgus Monkeys (2018) (0)
Development of Late over Early Full Donor Chimerism (FDC) Results in Improved Progression-Free and Overall Survival in Patients with Advanced Malignant Lymphomas Receiving Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation (HSCT). (2005) (0)
Lymphopenia Promotes the Development of Graft-Versus-Host Disease upon Donor Leukocyte Infusion. (2007) (0)
Recipient Cell Turnover of Gut-Resident Lymphocytes in Intestinal Allografts - Association of Delayed Turnover With Non-Rejecting Allografts.: Abstract# B1150 (2014) (0)
Host Environment Determines the Development of Gvhd but Not the Extent of Activation and Expansion of Gvh-Reactive CD4 T Cells (2008) (0)
NK1.1+ Cells Are Involved in the Anti-Tumor Immunity Induced by the Rejection of Donor Hematopoietic Cells in Mixed Bone Marrow Chimeras. (2006) (0)
Use of interleukin-12 to prevent reaction of the GVH. (1995) (0)
The Women of FOCIS: Promoting Equality and Inclusiveness in a Professional Federation of Clinical Immunology Societies (2022) (0)
INDUCTION OF T CELL TOLERANCE IN MINIATURE SWINE WITH ALLOGENEIC THYMUS TRANSPLANTS ACROSS A CLASS I BARRIER (1999) (0)
Fludarabine Treatment Is Associated with Depletion of Host CD4+CD25 high , FOXP3+, CTLA-4+ Cells and Increased Incidences of Full Donor Chimerism and GVHD in Non-Myeloablative Haploidentical Hematopoietic Cell Transplant Recipients. (2005) (0)
Reversal of Autoimmunity by Induction of Mixed Hematopoietic Chimerism: Evidence for Non-deletional Mechanisms (2010) (0)
MIXED CHIMERISM IS ESSENTIAL IN INDUCE SMALL BOWEL TRANSPLANTATION TOLERANCE IN MURINE MODEL (2006) (0)
The prospect of universal coronavirus immunity: a characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses (2023) (0)
Faculty Opinions recommendation of Antigen-primed CD8+ T cells can mediate resistance, preventing allogeneic marrow engraftment in the simultaneous absence of perforin-, CD95L-, TNFR1-, and TRAIL-dependent killing. (2003) (0)
Host Environment Dictates the Outcome Following Transfer of Graft-Versus-Host Reactive Effector/Memory T Cells. (2004) (0)
Xenogeneic thymic replacement to achieve immune restoration in HIV infection (2003) (0)
Transplant Arteriopathy Tolerance, Mixed Chimerism, and Chronic (2001) (0)
PRECLINICAL STUDY FOR TOLERANCE INDUCTION TO LIVER ALLOGRAFTS WITH RAPID IMMUNOSUPPRESSION WITHDRAWAL IN CYNOMOLGUS MONKEYS (2020) (0)
425.3: Single-Cell Immune Profiling of Human Intestinal Allografts Reveals Differential Phenotypes of Alloreactive T-Cell Clones in Quiescent vs Chronically Rejecting Allografts (2022) (0)
Interleukin-l 2 Inhibits Murine Graft-Versus-Host Disease (2000) (0)
T Cell and Myeloid Chimerism Without GVHD in Human Intestinal and Liver Transplantation: A Prospective Study.: Abstract# A3 (2014) (0)
Long-Lasting Anti-Tumor Immunity Induced by the Rejection of Donor Hematopoietic Cells in Mixed Bone Marrow Chimeras. (2005) (0)
Clonal expansion is of graft-versus-host reactive CD8+ T cells is dissociated from full effector diffrentiation (2007) (0)
Quantifying the Size and Diversity of the Human Alloresponse Via High-Throughput T Cell Receptor Sequencing (2017) (0)
Transgenic Expression of hCD47 on Vessels in Porcine GalTKO Lung Grafts in Baboons may Mitigate Acute Vascular Rejection in Baboons: Up to 13 Days Graft Survival in Baboons (2018) (0)
The First Tolerance Induction Model for Combined Liver and Donor Bone Marrow Transplantation in Cynomolgus Monkey.: Abstract# D2782 (2014) (0)
Mixed Bone Marrow Reconstitution Across MHC Barriers (1991) (0)
OPTIMAL T CELL DEPLETION IS ESSENTIAL FOR SUCCESSFUL THYMOKIDNEY TRANSPLANTS IN GALT-KO PIG TO BABOON MODEL: 2385 (2010) (0)
Use of interleukin-12 for the prevention of graft against empfaengerkrankheit (1995) (0)
Costimulatory blockade and mixed chimerism in allografts (1999) (0)
Alloreactive CD8 T cells require cell-intrinsic PD-1 and upregulate Nr4a and Egr family members during deletional tolerance in vivo (145.43) (2010) (0)
ROLE OF REGULATORY CELLS DEVELOPING IN PORCINE THYMUS GRAFTS IN TOLERANCE TO BOTH HOST AND DONOR ANTIGENS (1998) (0)
320.6: Potential biomarkers to guide immunosuppression management in intestinal transplant recipients (2019) (0)
Minimal HLA Disparity and KIR Ligand Compatibility in Host Versus Graft Direction May Facilitate Donor Engraftment Following In Vivo and Ex Vivo T Cell Depleted (TCD) Nonmyeloablative Haploidentical Stem Cell Transplantation for Hematologic Malignancies. (2005) (0)
CAN MIXED CHIMERISM BE ACHIEVED WITHOUT GVHD ACROSS HLA BARRIERS USING NON‐MYELOABLATIVE CONDITIONING WITH EXHAUSTIVE IN VIVO T CELL DEPLETION? PRELIMINARY EXPERIENCE IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES.: Abstract# 704 (2000) (0)
Faculty Opinions recommendation of Rejection of mouse cardiac allografts by costimulation in trans. (2001) (0)
NON‐MYELOABLATIVE BONE MARROW TRANSPLANTATION IN THE TREATMENT OF REFRACTORY LYMPHOMAS: ABSTRACT S18 (2000) (0)
ADVANTAGES OF RHESUS MACAQUES IN A TOLERANCE MODEL FOR COMBINED BONE MARROW AND KIDNEY TRANSPLANTATION (2020) (0)
The use of interleukin-12 for the prevention of graft-versus-host disease (1995) (0)
Hematopoietic Cell Transplantation for Induction of Transplantation Tolerance: From Animal Models to Clinical Trials (2010) (0)
CD40L-specific mAb mediates its tolerogenic effects through engagement of FcgRIIB, not via depletion of activated T cells (141.17) (2009) (0)
Receptor Calibration to a ''Useful'' Level with MHC Ligands: Evidence Against Determined by the Frequency of Interactions Levels of Ly-49 Receptor Expression Are (1999) (0)
HIGH LEVELS OF STABLE MULTI-LINEAGE HEMATOPOIETIC CHIMERISM AND DONOR-SPECIFIC ALLOGENEIC SKIN GRAFT TOLERANCE WITH T-CELL COSTIMULATORY BLOCKADE (1998) (0)
Immunosuppression Is Not Associated With High-Risk Immunologic Parameters In Transplant Recipients With The SARS-CoV2 Virus (2021) (0)
CAG repeat mutation in the mouse IL-2 gene enables concurrent assessment of T- and B-cell-specific gene expression by northern analysis. (1996) (0)
ANTI-CD40L MAB OVERCOMES CD4 T CELL-MEDIATED RESISTANCE TO XENOGENEIC MARROW ENGRAFTMENT (2004) (0)
Proliferation, Expansion, Effector Differentiation and Survival of GVH-Reactive T Cells Following Delayed DLI to Mixed Chimeras. (2004) (0)
Clinical relevance of recipient leukocyte infusion (RLI) therapy (2005) (0)
Cells to Porcine Donor MHC Grafts and Specific Tolerance of Human T Normal Development in Porcine Thymus (1999) (0)
CD8+ T CELL TOLERANCE AFTER BONE MARROW TRANSPLANTATION USING NON-MYELOABLATIVE CONDITIONING WITH TBI AND ANTI-CD154 MAB: IMPORTANCE OF SIGNAL 1, CD4+ T CELLS AND CTLA4, BUT NO EVIDENCE FOR LONG-TERM REGULATION (2004) (0)
SUCCESSFUL INDUCTION OF MIXED CHIMERISM AND TOLERANCE WITH NON-MYELOABLATIVE CONDITIONING IN MICE PRE-SENSITIZED WITH FULLY MHC MISMATCHED SKIN GRAFTS: 130 (2008) (0)
Lack of “Bystander” Activation and Evidence for Competition for Resources among Gvh-Reactive CD4 T Cells (2008) (0)
Acquired immunological tolerance (2014) (0)
Understanding Typhoid : A Mouse Model of Salmonella typhi Infection (2012) (0)
Recipient T Regulatory Cells Enhance Chimerism and Prolong Galt-KO pig Skin Graft Survival in Baboons (2018) (0)
PROLONGED XENOGENEIC SKIN GRAFT SURVIVAL AFTER XENOGENEIC PORCINE THYMIC TRANSPLANTATION IN A NON-HUMAN PRIMATE MODEL (1999) (0)
CD27 co-stimulation and co-inhibitory checkpoint blockade synergise by forcing exhausted CD8+T-cells to exit quiescence (2014) (0)
Using a Nonlymphoablative Irradiation-Free Mixed Chimerism and Allograft Tolerance Roles of Deletion and Regulation in Creating (2005) (0)
Phenotype and Function of Human Gut Hematopoietic Stem Cells and Progenitors (2017) (0)
Sequential Blockade and Engagement of Co-Stimulatory Pathways: A Potential Strategy for Amplifying Graft-Versus-Leukemia Responses without GVHD. (2004) (0)
REQUIREMENT FOR MHC CLASS I AND II EXPRESSION ON HOST DENDRITIC CELLS TO TOLERIZE ALLOREACTIVE CD8 CELLS DURING INDUCTION OF MIXED CHIMERISM: 652 (2008) (0)
A Role for Regulatory Cells in Tolerance Induction in Recipients of Haploidentical Combined Non-Myeloablative Bone Marrow and Kidney Transplantation?. (2007) (0)
Host-Versus-Graft Responses Antitumor Responses Induced by Invariant NKT Cells Are Required for (2010) (0)
Progress on macrochimerism and tolerance (2000) (0)
On cardiac xenotransplantation and the role of xenogeneic tolerance. (2022) (0)
Phenotype, Function and Expansion of Regulatory T Cells in the Cynomolgus Macaque (Macaca fascicularis) (2015) (0)
mixed hematopoietic chimerism Induction of human T-cell tolerance to porcine xenoantigens through (2013) (0)
prepared with nonmyeloablative conditioning chimeras T-cell-mediated rejection of the donor marrow in mixed allogeneic Graft-versus-host (GVH)-reactive donor CD4 cells can induce (2013) (0)
Mixed Chimerism Review and Transplant Tolerance (2001) (0)
SHORT-COURSE IMMUNOSUPPRESSION FACILITATES CHIMERISM AND TOLERANCE IN A NON-CYTOREDUCTIVE MODEL USING BMT AND COSTIMULATION BLOCKADEANONE MARROW TRANSPLANTATION (2004) (0)
337.9: Chimerism and Bidirectional Alloresponses in Patients Receiving Lung Transplantation (2022) (0)
T cell repertoire profiling in allografts and native tissues in recipients with COVID–19 after solid organ transplantation: Insight into T cell–mediated allograft protection from viral infection (2022) (0)
Tribute to Eda T. Bloom, PhD (2008) (0)
Transgenic Expression of hCD47 Minimizes the Development of Proteinuria Following Pig-to-Baboon Kidney Transplantation and Reduces Phagocytosis of Porcine Endothelial Cells and Podocytes (2018) (0)
Graft-versus-host alloresponses to treat nonlymphohematopoietic tumors: is there a solid approach? (2001) (0)
Clinical Relevance of Recipient Leukocyte Infusion (RLI) Therapy. (2004) (0)
A ONE‐DAY PROTOCOL OF BONE MARROW TRANSPLANTATION WITH COSTIMULATORY BLOCKADE FOR THE RAPID INDUCTION OF DONOR‐SPECIFIC SKIN GRAFT TOLERANCE WITHOUT PRE‐CONDITIONING.: Abstract# 994 (2000) (0)
Title Minimum Information about T Regulatory Cells : A Step toward Reproducibility and Standardization Permalink (2018) (0)
EARLY DELETION AFTER BONE MARROW TRANSPLANTATION WITH COSTIMULATORY BLOCKADE IS FAS-DEPENDENT AND IS PREVENTED BY BCL-XL OVEREXPRESSION (1999) (0)
Dynamics of B Cell Recovery in Tolerant Recipients of Combined Kidney Bone Marrow Transplantation.: Abstract# B787 (2014) (0)
Role for CD47-SIRP (cid:1) signaling in xenograft rejection by macrophages (2007) (0)
Introduction of David H. Sachs, MD, recipient of the 2014 Medawar Prize. (2015) (0)
INDUCTION OF ALLOREACTIVE CD4 TOLERANCE BY CROSS-PRESENTATION OF DONOR MHC MOLECULES BY RECIPIENT APCʼ: 651 (2008) (0)
HST.176 Cellular and Molecular Immunology, Fall 2002 (2002) (0)
Mixed Chimerism in Peripheral Blood and Allograft after Human Intestinal Transplantation and its Relationship with Clinical Outcomes (2017) (0)
Xenochimerism and tolerance (1995) (0)
Pig MHC Mediates Positive Selection of Mouse (1998) (0)
48 – Transplantation Immunology (2012) (0)
Treatment Approaches and Clinical Parameters Predictive of CMV Disease and Resolution in Immunodeficient Cynomolgus Macaques – a Clinically Relevant Large Animal Model (2016) (0)
Clonal and Functional Analysis Reveals the Capacity of Allograft T cells to Join the Circulating Pool after Human Intestinal Transplantation (2018) (0)
Non-Myeloablative T-Cell Depleted (TCD) Haploidentical Hematopoietic Cell Transplantation (HCT) Followed by Donor Leukocyte Infusion(s) for Hematologic Malignancies: The MGH Experience. (2007) (0)
Mixed Chimerism for the Induction of Transplantation Tolerance : From Rodent Models to Clinical Reality (2001) (0)
IMPROVED CD4 RECONSTITUTION IN THYMECTOMIZED, T/ NK CELL DEPLETED MICE GRAFTED IN ALTERNATIVE SITES WITH NEONATAL PORCINE THYMUS TISSUE.: Abstract# 561 Poster Board #‐Session: P199‐II (2000) (0)
A role for donor-derived B cells but not T cells in the maintenance of mixed hematopoietic chimerism. (2001) (0)
Marrow: Role of Donor Class II MHC and B Tolerance Induced by Allogeneic Bone Rapid Deletional Peripheral CD8 T Cell (2013) (0)
Strategies for the Induction of Allograft Tolerance (2001) (0)
Non-Hematopoietic Antigen Blocks Early Memory Imprinting Of Graft-Versus-Host Reactive CD8 Cells (2010) (0)
Requirement for CD4 Help for Optimal GVL Effects of Alloreactive T Cells Given to Established Mixed Chimeras but Not Freshly Irradiated Mice. (2004) (0)
OPTIMIZING EX-VIVO EXPANDED AUTOLOGOUS TREG INFUSIONS AND DISCOVERING THEIR FATE USING AN IN VIVO PRIMATE MODEL (2020) (0)
In Vivo and Ex Vivo T-Cell Depleted (TCD) NonmyeloablativeHaploidentical Stem Cell Transplantation (NSCT) for Hematologic Malignancy (HM). (2005) (0)
Durable Macrochimerism (>8 weeks) and Pig-Specific T and B Cell Unresponsiveness Following hCD47+ Transgenic GalTKO Pig Intra-Bone Bone Marrow Transplantation in Baboons (2018) (0)
Title: Tracking donor-reactive T cells: evidence for clonal deletion in tolerant kidney transplant patients (2016) (0)
PRIMATE TOLERANCE MODEL DEMONSTRATES LONGER KIDNEY GRAFT SURVIVAL WITH THE ADMINISTRATION OF POLYCLONAL EX-VIVO EXPANDED TREGS (2020) (0)
inhibition of epithelial tissue injury promotion of lymphohematopoietic graft-versus-host reactions and in graft-versus-host disease reflect γ Paradoxical effects of IFN (2009) (0)
Clonal expansion but impaired trafficking of GVH-reactive T cells following delayed DLI to mixed chimeras (2005) (0)
ASTS 17th Annual State of the Art Winter Symposium. (2017) (0)
Peripheral Interactions with APCs Conversion of Human T Cells Depend on Homeostatic Expansion and Phenotypic (2010) (0)
Interleukin-15 Receptor α Chain Knockout NOD-SCID mice have reduced numbers of NK cells, develop thymic lymphomas and fail to engraft human hematopoietic cells (2021) (0)
Megan Sykes, MD: Michael J. Friedlander Professor of Medicine and Professor of Microbiology & Immunology and Surgical Sciences (in Surgery) and Director of Columbia Center for Translational Immunology Columbia University, New York City, NY. (2017) (0)
334.5: Evidence for Xenogeneic Hematopoiesis After Peripheral Blood Stem Cell Transplantation From a Novel Transgenic Pig With Knock-in hIL-3 Receptor (2022) (0)
Business Meeting of the International Xenotransplantation Association (IXA), held in Goteborg, Sweden, September 13th, 2005 (2006) (0)
PORCINE CELLS ADHERE TO HUMAN FIBRONECTIN INDEPENDENTLY OF VLA-5: IMPLICATIONS FOR PORCINE TO HUMAN XENOTRANSPLANTATION. (1999) (0)
Failure to imprint donor CD8 memory and exhaustion may explain loss of GVT responses following donor leukocyte infusions (2010) (0)
CO-TRANSPLANTING A VASCULARIZED DONOR THYMIC GRAFT AND LIFE-SUPPORTING KIDNEY USING GALT-KO DONORS IN BABOONS (2004) (0)
CRUCIAL ROLE OF INDIRECT ALLORECOGNITION BY CD4 T CELLS FOR CD8 T CELL TOLERANCE INDUCTION. (2006) (0)
ALLORESPONSES IN TOLERANT RECIPIENTS OF COMBINED KIDNEY/BONE MARROW TRANSPLANTATION WITH NON-MYELOABLATIVE CONDITIONING (2004) (0)
T CELL-DEPLETED ALLOGENEIC BONE MARROW TRANSPLANTATION (BMT) INDUCES MIXED CHIMERISM AND DONOR - SPECIFIC TOLERANCE AND PREVENTS DIABETES IN NOD MICE RECEIVING LOW-DOSE (4 GY) TOTAL BODY IRRADIATION (TBI), CD8 T CELL DEPLETION, AND ANTI-CD40LMAB. (2004) (0)
PORCINE THYMUS SUPPORTS DEVELOPMENT OF FUNCTIONAL HUMANT T CELLS (1998) (0)
CONCURRENT SESSION 26: APPROACHES TO TOLERANCE IN THE CLINIC (2006) (0)
Splenic IgM Natural Antibody-Producing Peritoneal Cavity B Cells Are Precursors of (2003) (0)
24: PD-1 is required to induce peripheral CD8 T cell tolerance in recipients of allogeneic bone marrow transplantation with anti-CD154 (2007) (0)
Role of indirect presentation of donor antigens in the antitumor responses induced by recipient leukocyte infusion in mixed chimeras prepared with nonmyeloablative conditioning (2003) (0)
F.94. Overcoming CD8 T Cell-Mediated Resistance to Engraftment of Allogeneic Bone Marrow Cells (2008) (0)
210.4: Dynamic repopulation, phenotypic evolution and clonal distribution of recipient B cells and plasma cells in graft mucosa associated with rejection after human intestinal transplantation (2019) (0)
Progress in xenotransplantation: overcoming immune barriers (2022) (0)
Targeting CD134 Results in Selective Depletion of Alloreactive Human T Cells without Loss of Virus-Specific and Leukemia-Specific Effectors. (2007) (0)
cells transplantation: evidence for anergy and deletion but not regulatory anti-CD154 monoclonal antibody and allogeneic bone marrow Mechanisms of early peripheral CD4 T-cell tolerance induction by (2013) (0)
Thymic Generation of Donor-Derived T Cell From Intestinal Lymphoid Progenitors After Human Small Bowel Transplantation.: Abstract# B1131 (2014) (0)
The effects of rapamycin and cyclosporin a on tolerance induction through bone marrow transplantation with costimulation blockade (2002) (0)
ECONOMIC IMPACT OF TOLERANCE INDUCTION BY COMBINED KIDNEY AND BONE MARROW TRANSPLANTATION: 1487 (2008) (0)
Sequential blockade and engagement of costimulatory pathways: A potential strategy for amplifying graft-versus-leukemia responses without graft-versus-host disease (2005) (0)
Induced tolerance to transplants (1993) (0)
AGONISTIC CO-STIMULATION SYNERGIZES WITH CO-INHIBITORY BLOCKADE TO REVERSE EXHAUSTION OF HELPLESS CD8 T CELLS (2014) (0)
LIFE-SUPPORTING PIG VASCULARIZED-THYMUS PLUS KIDNEY TRANSPLANTATION LEADS TO GENERATION OF NEW BABOON T-CELLS AND SWINE-SPECIFIC HYPORESPONSIVENESS (2020) (0)
Increased Frequency of Regulatory T Cells in Patients Receiving Hla Haploidentical Combined Kidney and Bone Marrow Transplantation to Induce Tolerance: 1954 (2010) (0)
-Producing g Infusion-Derived IFN-T Cells and Recipient Leukocyte + CD4Conditioning: A Critical Role for Recipient Chimeras Prepared with Nonmyeloablative Recipient Leukocyte Infusions in Mixed Host-versus-Graft Reactions Induced by Mechanisms of the Antitumor Responses and (2005) (0)
Donor Specific Unresponsiveness Develops Following Loss of Chimerism in Recipients of Haploidentical Combined Bone Marrow/Kidney Transplantation but Not in Recipients of Bone Marrow Transplant Alone. (2006) (0)
Cell Death Activation-Induced Cell Death and Passive Blockade Has Features of Both Transplantation with Costimulatory Peripheral Deletion After Bone Marrow (2001) (0)
PD-1 IS ESSENTIAL TO INDUCE PERIPHERAL CD8 T CELL TOLERANCE IN ALLOGENEIC BONE MARROW TRANSPLANTATION (2006) (0)
231.6: Tolerance of Allogeneic Kidneys With Durable (>365 Days) Multilineage Chimerism and Bone Marrow Engraftment in Cynomolgus Macaques (2022) (0)
ONE INJECTION OF ANTI‐CD40L MAB OVERCOMES CD4 T CELL‐MEDIATED RESISTANCE TO FULLY MHC‐MISMATCHED ALLOGENEIC MARROW ENGRAFTMENT.: Abstract# 995 (2000) (0)
Macrophages in Mice Elimination of Porcine Hemopoietic Cells by (0)
Tribute to Carl-Gustav Groth (1933-2014), first president of the International Xenotransplantation Association. (2014) (0)
OR.66. Critical Role of Recipient B Cells for CD8 T Cell Tolerance Required to Permit Engraftment of Allogeneic Bone Marrow Cells (2008) (0)
Mixed Bone Marrow Chimeras as an Approach to Transplantation Tolerance (1987) (0)

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