Meinhard Kieser

Meinhard Kieser's AcademicInfluence.com Rankings

Meinhard Kieser

Computer Science

#9776

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#10256

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Machine Learning

#4372

World Rank

#4422

Historical Rank

Artificial Intelligence

#4723

World Rank

#4786

Historical Rank

Database

#6732

World Rank

#6970

Historical Rank

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Computer Science

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Meinhard Kieser's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial (2011) (464)
Effect of Conscious Sedation vs General Anesthesia on Early Neurological Improvement Among Patients With Ischemic Stroke Undergoing Endovascular Thrombectomy: A Randomized Clinical Trial. (2016) (388)
Affective disorders and survival after acute myocardial infarction. Results from the post-infarction late potential study. (1991) (347)
St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. (1998) (322)
Combining different phases in the development of medical treatments within a single trial. (1999) (267)
Interrupted or Continuous Slowly Absorbable Sutures For Closure of Primary Elective Midline Abdominal Incisions: A Multicenter Randomized Trial (INSECT: ISRCTN24023541) (2009) (221)
Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomised controlled double blind non-inferiority trial versus paroxetine (2005) (211)
Cryoballoon Versus Open Irrigated Radiofrequency Ablation in Patients With Paroxysmal Atrial Fibrillation (2015) (199)
Kava-kava extract WS 1490 versus placebo in anxiety disorders--a randomized placebo-controlled 25-week outpatient trial. (1997) (194)
Sample Size Recalculation in Internal Pilot Study Designs: A Review (2006) (173)
To test or not to test: Preliminary assessment of normality when comparing two independent samples (2012) (165)
Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus. (2013) (164)
A 26-Week Analysis of a Double-Blind, Placebo-Controlled Trial of the Ginkgo biloba Extract EGb 761® in Dementia (2000) (161)
A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type. (2005) (160)
Sustained Effects of a Mindfulness-Based Stress-Reduction Intervention in Type 2 Diabetic Patients (2012) (159)
Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial. (2002) (152)
Preoperative chemo(radio)therapy versus primary surgery for gastroesophageal adenocarcinoma: systematic review with meta-analysis combining individual patient and aggregate data. (2013) (143)
Effectiveness of triclosan-coated PDS Plus versus uncoated PDS II sutures for prevention of surgical site infection after abdominal wall closure: the randomised controlled PROUD trial (2014) (138)
Re-calculating the sample size in internal pilot study designs with control of the type I error rate. (2000) (129)
Granulocyte Colony–Stimulating Factor in Patients With Acute Ischemic Stroke: Results of the AX200 for Ischemic Stroke Trial (2013) (128)
Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany (2020) (126)
Influence of the Severity of Cognitive Impairment on the Effect of the Ginkgo biloba Extract EGb 761® in Alzheimer’s Disease (2002) (121)
Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS - a randomised controlled multicentre trial (ISRCTN30964555) (2012) (114)
On the Use of the Upper Confidence Limit for the Variance from a Pilot Sample for Sample Size Determination (1996) (112)
Inference on Multiple Endpoints in Clinical Trials with Adaptive Interim Analyses (1999) (111)
Simple procedures for blinded sample size adjustment that do not affect the type I error rate (2003) (110)
Superior efficacy of St John's wort extract WS® 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298] (2006) (108)
Association of General Anesthesia vs Procedural Sedation With Functional Outcome Among Patients With Acute Ischemic Stroke Undergoing Thrombectomy: A Systematic Review and Meta-analysis. (2019) (107)
Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. (2007) (105)
Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial (2017) (100)
Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: The CLEOPATRA Trial (2010) (88)
Sample size determination for proving equivalence based on the ratio of two means for normally distributed data. (1999) (87)
Sedation vs. Intubation for Endovascular Stroke TreAtment (SIESTA) – A Randomized Monocentric Trial (2015) (83)
A comparison of methods for adaptive sample size adjustment (2001) (80)
Dual-energy perfusion-CT of pancreatic adenocarcinoma. (2013) (75)
Influence of a 7-day treatment with Ginkgo biloba special extract EGb 761 on bleeding time and coagulation: a randomized, placebo-controlled, double-blind study in healthy volunteers (2004) (75)
Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trial. (2009) (74)
Demonstration of the efficacy of ginkgo biloba special extract EGb 761 on intermittent claudication--a placebo-controlled, double-blind multicenter trial. (1998) (73)
DISPACT trial: a randomized controlled trial to compare two different surgical techniques of DIStal PAnCreaTectomy — study rationale and design (2008) (72)
Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. (1996) (71)
Risk–benefit assessment of closed intra-abdominal drains after pancreatic surgery: a systematic review and meta-analysis assessing the current state of evidence (2011) (69)
Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial. (2001) (67)
Computed Tomography Perfusion Analysis of Pancreatic Carcinoma (2012) (60)
HAnd Suture Versus STApling for Closure of Loop Ileostomy (HASTA Trial): Results of a Multicenter Randomized Trial (DRKS00000040) (2012) (57)
Efficacy and tolerability of EPs 7630 in children and adolescents with acute bronchitis - a randomized, double-blind, placebo-controlled multicenter trial with a herbal drug preparation from Pelargonium sidoides roots. (2010) (56)
Association of Blood Pressure With Short- and Long-Term Functional Outcome After Stroke Thrombectomy: Post Hoc Analysis of the SIESTA Trial (2018) (55)
Sample size recalculation for binary data in internal pilot study designs (2004) (54)
Efficacy and tolerability of EPs 7630 in patients (aged 6–18 years old) with acute bronchitis (2010) (54)
Randomised trial of proton vs. carbon ion radiation therapy in patients with low and intermediate grade chondrosarcoma of the skull base, clinical phase III study (2010) (53)
Group-based cognitive behavioural psychotherapy for children and adolescents with ASD: the randomized, multicentre, controlled SOSTA-net trial. (2016) (53)
Insertion of Totally Implantable Venous Access Devices: An Expertise-Based, Randomized, Controlled Trial (NCT00600444) (2011) (52)
On the inappropriateness of an EM algorithm based procedure for blinded sample size re‐estimation (2002) (51)
Continuation and long-term maintenance treatment with Hypericum extract WS® 5570 after recovery from an acute episode of moderate depression — A double-blind, randomized, placebo controlled long-term trial (2008) (50)
Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children: a randomized controlled trial in Burkina Faso. (2015) (50)
A unifying approach for confidence intervals and testing of equivalence and difference (1996) (50)
Planning and analysis of three‐arm non‐inferiority trials with binary endpoints (2007) (49)
Assessment of statistical significance and clinical relevance (2013) (49)
Better tolerability of St. John's wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression (2010) (48)
Rapid body mass loss affects erythropoiesis and hemolysis but does not impair aerobic performance in combat athletes (2016) (48)
Conduct disorder in adolescent females: current state of research and study design of the FemNAT-CD consortium (2018) (45)
Opportunities and challenges of combined effect measures based on prioritized outcomes (2014) (45)
Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides (2010) (45)
The SETscore to Predict Tracheostomy Need in Cerebrovascular Neurocritical Care Patients (2016) (44)
Treatment of acute bronchitis with EPs 7630: Randomized, controlled trial in children and adolescents (2012) (44)
Clinical significance of hyperforin for the efficacy of Hypericum extracts on depressive disorders of different severities. (1998) (43)
Blinded sample size reassessment in non‐inferiority and equivalence trials (2003) (42)
Phase I/II trial evaluating carbon ion radiotherapy for the treatment of recurrent rectal cancer: the PANDORA-01 trial (2012) (42)
A systematic comparison of recurrent event models for application to composite endpoints (2018) (41)
Prevalence of intracardiac thrombi under phenprocoumon, direct oral anticoagulants (dabigatran and rivaroxaban), and bridging therapy in patients with atrial fibrillation and flutter. (2015) (41)
Efficacy of St. John’s wort extract WS® 5570 in acute treatment of mild depression (2007) (41)
Comparison of carbon ion radiotherapy to photon radiation alone or in combination with temozolomide in patients with high-grade gliomas: explorative hypothesis-generating retrospective analysis. (2013) (40)
Comparison of Hypericum extract WS 5570 and paroxetine in ongoing treatment after recovery from an episode of moderate to severe depression: results from a randomized multicenter study. (2006) (39)
Quality of reporting of clinical non-inferiority and equivalence randomised trials - update and extension (2012) (39)
Relapsed/refractory acute myeloid leukemia: any progress? (2017) (38)
Cluster-randomised trial evaluating a complex intervention to improve mental health and well-being of employees working in hospital – a protocol for the SEEGEN trial (2019) (37)
Early tracheostomy in ventilated stroke patients: Study protocol of the international multicentre randomized trial SETPOINT2 (Stroke-related Early Tracheostomy vs. Prolonged Orotracheal Intubation in Neurocritical care Trial 2) (2016) (37)
Assessment of clinical relevance by considering point estimates and associated confidence intervals (2005) (36)
Hamamelis in children with skin disorders and skin injuries: results of an observational study (2007) (34)
Pulmonary and circulatory parameter guided anesthesia in patients with ischemic stroke undergoing endovascular recanalization (2015) (33)
Blinded sample size recalculation for clinical trials with normal data and baseline adjusted analysis (2011) (32)
Approximate sample sizes for testing hypotheses about the ratio and difference of two means. (1999) (31)
ChroPac-Trial: Duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for chronic pancreatitis. Trial protocol of a randomised controlled multicentre trial (2010) (31)
Placebo-Controlled Trials in Surgery (2016) (31)
A non-controlled, single arm, open label, phase II study of intravenous and intratumoral administration of ParvOryx in patients with metastatic, inoperable pancreatic cancer: ParvOryx02 protocol (2017) (31)
Blinded sample size re‐estimation in superiority and noninferiority trials: bias versus variance in variance estimation (2013) (30)
The group-based social skills training SOSTA-FRA in children and adolescents with high functioning autism spectrum disorder - study protocol of the randomised, multi-centre controlled SOSTA - net trial (2013) (30)
Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for COVID-19 (2021) (29)
Power and sample size determination when assessing the clinical relevance of trial results by ‘responder analyses’ (2004) (29)
Diagnostic instruments for autism spectrum disorder (ASD) (2016) (28)
Randomised, double-blind, placebo-controlled trial of EPs 7630 in adults with COPD. (2013) (28)
A general approach for sample size calculation for the three‐arm ‘gold standard’ non‐inferiority design (2012) (28)
[Placebo-controlled double-blind study of the effectiveness of Ginkgo biloba special extract EGb 761 in trained patients with intermittent claudication]. (1996) (27)
Optimal adaptive two‐stage designs for phase II cancer clinical trials (2013) (27)
Proof of Safety in Toxicology Based on the Ratio of Two Means for Normally Distributed Data (1999) (26)
Phase II study evaluating consolidation whole abdominal intensity-modulated radiotherapy (IMRT) in patients with advanced ovarian cancer stage FIGO III - The OVAR-IMRT-02 Study (2011) (26)
Urinary excretion of high molecular weight adiponectin is an independent predictor of decline of renal function in type 2 diabetes (2013) (25)
A comparison of Bayesian and frequentist methods in random‐effects network meta‐analysis of binary data (2020) (25)
Fostering efficacy of anti-PD-1-treatment: Nivolumab plus radiotherapy in advanced non-small cell lung cancer - study protocol of the FORCE trial (2019) (25)
Procedures for testing multiple endpoints in clinical trials: An overview (1999) (25)
Opportunities and challenges of clinical trials in cardiology using composite primary endpoints. (2015) (25)
Refining scores based on patient reported outcomes – statistical and medical perspectives (2019) (25)
Rationale and design of the FreezeAF trial: a randomized controlled noninferiority trial comparing isolation of the pulmonary veins with the cryoballoon catheter versus open irrigated radiofrequency ablation in patients with paroxysmal atrial fibrillation. (2010) (25)
DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy (2012) (25)
Community Violence Exposure and Conduct Problems in Children and Adolescents with Conduct Disorder and Healthy Controls (2017) (24)
Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial. (2022) (24)
Decision Rules for Subgroup Selection Based on a Predictive Biomarker (2014) (24)
Blinded Sample Size Reestimation in Multiarmed Clinical Trials (2000) (24)
Configural Frequency Analysis (CFA) Revisited — a New Look at an Old Approach (1999) (23)
Bright light therapy versus physical exercise to prevent co-morbid depression and obesity in adolescents and young adults with attention-deficit / hyperactivity disorder: study protocol for a randomized controlled trial (2018) (23)
Phase I study evaluating the treatment of patients with locally advanced pancreatic cancer with carbon ion radiotherapy: the PHOENIX-01 trial (2013) (22)
Prognostic factors, patterns of recurrence and toxicity for patients with esophageal cancer undergoing definitive radiotherapy or chemo-radiotherapy (2015) (22)
A closer look at the effect of preliminary goodness-of-fit testing for normality for the one-sample t-test. (2011) (22)
Efficacy of kava-kava in the treatment of non-psychotic anxiety, following pretreatment with benzodiazepines (2001) (22)
Sequential and Multiple Testing for Dose-Response Analysis (2000) (22)
A weighted combined effect measure for the analysis of a composite time‐to‐first‐event endpoint with components of different clinical relevance (2018) (21)
Endovascular stroke treatment’s impact on malignant type of edema (ESTIMATE) (2018) (21)
Whole brain radiation therapy alone versus radiosurgery for patients with 1–10 brain metastases from small cell lung cancer (ENCEPHALON Trial): study protocol for a randomized controlled trial (2018) (21)
Competing time-to-event endpoints in cardiology trials: A simulation study to illustrate the importance of an adequate statistical analysis (2014) (20)
Adaptive designs for single‐arm phase II trials in oncology (2012) (20)
A Bootstrap Procedure for Adaptive Selection of the Test Statistic in Flexible Two‐Stage Designs (2002) (20)
Blinded sample size re‐estimation in crossover bioequivalence trials (2014) (19)
Improving the Flexibility and Efficiency of Phase II Designs for Oncology Trials (2012) (19)
Clinical effect of stannous fluoride and amine fluoride containing oral hygiene products: A 4-year randomized controlled pilot study (2019) (19)
A method for using real world data in breast cancer modeling (2016) (19)
Multiple Testing to Establish Noninferiority of k Treatments with a Reference Based on the Ratio of Two Means (2001) (19)
Education to a Healthy Lifestyle Improves Symptoms and Cardiovascular Risk Factors – AsuRiesgo Study (2015) (19)
Sample size planning for phase II trials based on success probabilities for phase III (2015) (19)
Prevention of abdominal wound infection (PROUD trial, DRKS00000390): study protocol for a randomized controlled trial (2011) (19)
Maturation of the Cardiac Autonomic Nervous System Activity in Children and Adolescents (2021) (19)
Children of Mentally III Parents at Risk Evaluation (COMPARE): Design and Methods of a Randomized Controlled Multicenter Study—Part I (2019) (18)
Two‐stage designs for cross‐over bioequivalence trials (2015) (18)
Identification of Adverse Drug Reactions by Evaluation of a Prescription Database, Demonstrated for “Risk of Bleeding” (2005) (18)
APOE Genotype and Alzheimer´s Disease (2000) (18)
Utility‐based optimization of phase II/III programs (2016) (18)
Multiplicity Adjustment for Composite Binary Endpoints (2012) (18)
Bayesian network meta‐analysis for cluster randomized trials with binary outcomes (2017) (17)
Choice of futility boundaries for group sequential designs with two endpoints (2017) (17)
Meta-analysis of preoperative chemotherapy (CTX) versus primary surgery for locoregionally advanced adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus (GE adenocarcinoma). (2010) (17)
Pinimenthol® ointment in patients suffering from upper respiratory tract infections – A post-marketing observational study (2007) (17)
Cryoballoon vs. open irrigated radiofrequency ablation for paroxysmal atrial fibrillation: long-term FreezeAF outcomes (2017) (17)
Design and current status of CONTINT: continuous versus interrupted abdominal wall closure after emergency midline laparotomy - a randomized controlled multicenter trial [NCT00544583] (2012) (16)
Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis. (2018) (16)
Baseline autonomic nervous system activity in female children and adolescents with conduct disorder: Psychophysiological findings from the FemNAT-CD study (2019) (16)
Time-to-first-event versus recurrent-event analysis: points to consider for selecting a meaningful analysis strategy in clinical trials with composite endpoints (2018) (16)
Predictors for Failure of Early Neurological Improvement After Successful Thrombectomy in the Anterior Circulation (2021) (16)
Memorandum “Open Metadata” (2015) (16)
Resting autonomic nervous system activity is unrelated to antisocial behaviour dimensions in adolescents: Cross-sectional findings from a European multi-centre study (2018) (15)
A variational approach to optimal two‐stage designs (2019) (15)
Methods for proper handling of overrunning and underrunning in phase II designs for oncology trials (2015) (15)
Point estimation in adaptive enrichment designs (2017) (14)
Use of the wearable cardioverter-defibrillator (WCD) and WCD-based remote rhythm monitoring in a real-life patient cohort (2018) (14)
The German trial on Aciclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis (GACHE): a multicenter, randomized, double-blind, placebo-controlled trial (2019) (14)
Safety and efficacy of artesunate-amodiaquine combined with either methylene blue or primaquine in children with falciparum malaria in Burkina Faso: A randomized controlled trial (2019) (14)
[PREFERE - the German prostatic cancer study: questions and claims surrounding study initiation in January 2013]. (2013) (14)
The Impact of Conscious Sedation versus General Anesthesia for Stroke Thrombectomy on the Predictive Value of Collateral Status: A Post Hoc Analysis of the SIESTA Trial (2017) (14)
Clinical management and prevention of dental caries in athletes: A four-year randomized controlled clinical trial (2018) (14)
A Note on Change Point Estimation in Dose-Response Trials (2001) (14)
A test procedure for an alternative approach to configural frequency analysis. (1991) (14)
The role of combined ion-beam radiotherapy (CIBRT) with protons and carbon ions in a multimodal treatment strategy of inoperable osteosarcoma. (2021) (14)
Curtailment in single‐arm two‐stage phase II oncology trials (2012) (13)
A Comparison of Procedures for Adaptive Choice of Location Tests in Flexible Two‐Stage Designs (2003) (13)
Predictors of overall and recurrence-free survival after neoadjuvant chemotherapy for gastroesophageal adenocarcinoma: Pooled analysis of individual patient data (IPD) from randomized controlled trials (RCTs). (2017) (13)
Predictors of symptomatic intracranial haemorrhage in off‐label thrombolysis: an analysis of the Safe Implementation of Treatments in Stroke registry (2018) (13)
Optimal Decision Rules for Biomarker-Based Subgroup Selection for a Targeted Therapy in Oncology (2015) (12)
Blinded Sample Size Recalculation for Normally Distributed Outcomes Using Long‐ and Short‐term Data (2003) (12)
Predicting stable treatment response in patients with major depression treated with hypericum extract WS 5570/5572. (2005) (12)
Point estimation and p‐values in phase II adaptive two‐stage designs with a binary endpoint (2017) (12)
Optimal Two-stage Designs for Single-arm Phase II Oncology Trials with Two Binary Endpoints (2010) (12)
Why do you need a biostatistician? (2020) (12)
Primary Open Versus Closed Implantation Strategy for Totally Implantable Venous Access Ports (2019) (12)
Placebo controlled continuation treatment with Hypericum extract WS® 5570 after recovery from a mild or moderate depressive episode (2007) (12)
Hypothesis testing in Bayesian network meta-analysis (2018) (12)
Assessment of Safety (2020) (12)
What makes a biostatistician? (2018) (12)
Two-stage phase II oncology designs using short-term endpoints for early stopping (2017) (12)
The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy—A Matched Pair Analysis (2019) (11)
An expected power approach for the assessment of composite endpoints and their components (2013) (11)
Sample size calculations for noninferiority trials with Poisson distributed count data (2013) (11)
Adjuvant Intensity Modulated Whole-Abdominal Radiation Therapy for High-Risk Patients With Ovarian Cancer (International Federation of Gynecology and Obstetrics Stage III): First Results of a Prospective Phase 2 Study. (2017) (11)
Blinded sample size recalculation in clinical trials with binary composite endpoints (2017) (11)
Sample Size Reassessment in Non-inferiority Trials (2010) (10)
Considerations on what constitutes a ‘qualified statistician’ in regulatory guidelines (2012) (10)
Phase 2 Trial of Oncolytic H-1 Parvovirus Therapy Shows Safety and Signs of Immune System Activation in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (2021) (10)
Prophylactic anticoagulation in patients with glioblastoma or brain metastases and atrial fibrillation: an increased risk for intracranial hemorrhage? (2021) (10)
Consistency-adjusted alpha allocation methods for a time-to-event analysis of composite endpoints (2014) (10)
Efficacy and tolerability of EPs 7630 in patients (aged 6–18 years old) with acute bronchitis A randomized, double-blind, placebo-controlled clinical dose-finding study (2010) (9)
Comparative analysis of tissue fluorescence as related to capillary perfusion in random pattern skin flaps. (1992) (9)
Adjuvant intensity modulated whole-abdominal radiation therapy for high-risk patients with ovarian cancer FIGO stage III: final results of a prospective phase 2 study (2019) (9)
Predictors of Residual Tumor in Breast-Conserving Therapy (2015) (9)
Hand-suture versus stapling for closure of loop ileostomy: HASTA-Trial: a study rationale and design for a randomized controlled trial (2011) (9)
Blinded assessment of treatment effects utilizing information about the randomization block length (2009) (9)
Investigations on non‐inferiority—the Food and Drug Administration draft guidance on treatments for nosocomial pneumonia as a case for exact tests for binomial proportions (2013) (9)
Ion therapy within the trimodal management of superior sulcus tumors: the INKA trial (2015) (8)
A Note on Adaptively Changing the Hierarchy of Hypotheses in Clinical Trials with Flexible Design (2005) (8)
The Average Hazard Ratio – A Good Effect Measure for Time-to-event Endpoints when the Proportional Hazard Assumption is Violated? (2018) (8)
Easily applicable multiple testing procedures to improve the interpretation of clinical trials with composite endpoints. (2014) (8)
Some Issues of Sample Size Calculation for Time-to-Event Endpoints Using the Freedman and Schoenfeld Formulas (2015) (8)
Sample Size Adjustment in Clinical Trials for Proving Equivalence (2001) (8)
Test‐compatible confidence intervals for adaptive two‐stage single‐arm designs with binary endpoint (2018) (8)
Carbon ion radiotherapy as definitive treatment in non-metastasized pancreatic cancer: study protocol of the prospective phase II PACK-study (2020) (8)
Disease-free survival as a surrogate for overall survival in neoadjuvant trials of gastroesophageal adenocarcinoma: Pooled analysis of individual patient data from randomised controlled trials. (2019) (8)
Adenoid cystic Carcinoma and Carbon ion Only irradiation (ACCO): Study protocol for a prospective, open, randomized, two-armed, phase II study (2021) (8)
Evaluation of Stereotactic Radiotherapy of the Resection Cavity After Surgery of Brain Metastases Compared to Postoperative Whole-Brain Radiotherapy (ESTRON)—A Single-Center Prospective Randomized Trial (2018) (7)
A new conditional performance score for the evaluation of adaptive group sequential designs with sample size recalculation (2020) (7)
Blinded sample size recalculation in multicentre trials with normally distributed outcome (2010) (7)
Including long- and short-term data in blinded sample size recalculation for binary endpoints (2004) (7)
Neoadjuvant irradiation of retroperitoneal soft tissue sarcoma with ions (Retro-Ion): study protocol for a randomized phase II pilot trial (2021) (7)
Optimal adaptive two-stage designs for single-arm trial with binary endpoint (2016) (7)
Robotic Radiosurgery for Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence (CYBER-SPACE)—A Single-Center Prospective Randomized Trial (2019) (7)
Continuation and long‐term maintenance treatment with Hypericum extract WS® 5570 after successful acute treatment of mild to moderate depression – rationale and study design (2004) (7)
A confirmatory strategy for therapeutic equivalence trials. (1995) (6)
Hemodynamic Status During Endovascular Stroke Treatment: Association of Blood Pressure with Functional Outcome (2021) (6)
Adaptive Designs for Two Candidate Primary Time-to-Event Endpoints (2016) (6)
Simon's Minimax and Optimal and Jung's Admissible Two-stage Designs with or without Curtailment (2011) (6)
OneArmPhaseTwoStudy: An R Package for Planning, Conducting, and Analysing Single-Arm Phase II Studies (2017) (6)
Individualized blood pressure management during endovascular treatment of acute ischemic stroke under procedural sedation (INDIVIDUATE) – An explorative randomized controlled trial (2021) (6)
Perioperative chemotherapy versus primary surgery for locoregionally advanced resectable adenocarcinoma of the stomach, gastroesophageal junction and lower esophagus (2009) (6)
Identification of physicians with unusual performance in screening colonoscopy databases: a Bayesian approach. (2015) (6)
Blinded Sample Size Recalculation in Longitudinal Clinical Trials Using Generalized Estimating Equations (2013) (6)
Simulation and data‐generation for random‐effects network meta‐analysis of binary outcome (2019) (5)
Utilizing radar graphs in the visualization of simulation and estimation results in network meta‐analysis (2020) (5)
Comparison of Methods for Estimating Therapy Effects by Indirect Comparisons: A Simulation Study (2020) (5)
Modeling the Recovery from Depressive Illness by an Exponential Model with Mixed Effects (2000) (5)
[Ginkgo biloba special extract EGb 761--an anti-dementia drug]. (1998) (5)
A comparison of group sequential and fixed sample size designs for bioequivalence trials with highly variable drugs (2018) (5)
Adaptive designs for clinical trials with multiple endpoints (2015) (5)
The adoptr Package: Adaptive Optimal Designs for Clinical Trials in R (2021) (5)
Optimal planning of adaptive two‐stage designs (2021) (5)
Planning and analysis of three‐arm non‐inferiority trials with binary endpoints (2010) (5)
Optimal adaptive single-arm phase II trials under quantified uncertainty (2020) (5)
Research data closer to expectation than compatible with random sampling. (2005) (5)
Categories, components, and techniques in a modular construction of basket trials for application and further research (2021) (5)
Statistical Methods for Demonstrating Equivalence in Crossover Trials Based on the Ratio of Two Location Parameters (2000) (5)
Estimation of secondary endpoints in two‐stage phase II oncology trials (2012) (5)
Optimal designs for phase II/III drug development programs including methods for discounting of phase II results (2020) (4)
Treatment of acute bacterial maxillary sinusitis with EPs 7630‐solution: a randomised, double‐blind, placebo‐controlled trial (2010) (4)
Full Reperfusion Without Functional Independence After Mechanical Thrombectomy in the Anterior Circulation (2022) (4)
Assessing additional benefit in noninferiority trials (2016) (4)
Pinimenthol ointment in patients suffering from upper respiratory tract infections - a post-marketing observational study. (2010) (4)
Erratum to: Risk–benefit assessment of closed intra-abdominal drains after pancreatic surgery: a systematic review and meta-analysis assessing the current state of evidence (2011) (4)
Stem cell Transplantation for Eradication of Minimal PAncreatic Cancer persisting after surgical Excision (STEM PACE Trial, ISRCTN47877138): study protocol for a phase II study (2014) (4)
Efficacy and Safety of the Platelet-Activating Factor Receptor Antagonist BN 52021 (Ginkgolide B) in Patients with Severe Sepsis (2004) (4)
Sample Size Calculation and Blinded Sample Size Recalculation in Clinical Trials Where the Treatment Effect is Measured by the Relative Risk (2013) (4)
Durvalumab in frail and elderly patients with stage four non-small cell lung cancer: Study protocol of the randomized phase II DURATION trial (2020) (4)
Study protocol of the multi-centre, randomised controlled trial of the Frankfurt Early Intervention Programme A-FFIP versus early intervention as usual for toddlers and preschool children with Autism Spectrum Disorder (A-FFIP study) (2019) (4)
Psychometric validation of the Breast Cancer Treatment Outcome Scale (BCTOS-12): a prospective cohort study (2019) (4)
Prognostic relevance of elevated pulmonary arterial pressure assessed non-invasively: Analysis in a large patient cohort with invasive measurements in near temporal proximity (2018) (3)
Sample size calculation and blinded recalculation for analysis of covariance models with multiple random covariates (2018) (3)
Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials (2020) (3)
Antibiotic sutures against surgical site infections–Authors' reply (2014) (3)
Blinded sample size recalculation in clinical trials incorporating historical data. (2017) (3)
Optimal planning of phase II/III programs for clinical trials with multiple endpoints (2018) (3)
Optimal Interim Decision Rules Based on a Binary Surrogate Outcome for Adaptive Biomarker-Based Trials in Oncology (2017) (3)
Emergency intubation during thrombectomy for acute ischemic stroke in patients under primary procedural sedation (2021) (3)
Performance of Biomarker-Based Subgroup Selection Rules in Adaptive Enrichment Designs (2016) (3)
Simulation‐based adjustment after exploratory biomarker subgroup selection in phase II (2017) (3)
Psychophysiological responses to sadness in girls and boys with conduct disorder. (2020) (3)
Optimal sample size allocation and go/no‐go decision rules for phase II/III programs where several phase III trials are performed (2018) (3)
Timing of the interim analysis in adaptive enrichment designs (2018) (2)
[Outcomes of multimorbid vascular surgery patients with and without major amputation in a German geriatric rehabilitation clinic]. (2018) (2)
Configural frequency analysis and association analyses in contingency tables (2003) (2)
Statistical methods for the analysis of adverse event data (2016) (2)
Adaptive propensity score procedure improves matching in prospective observational trials (2019) (2)
Transition probabilities of HER2-positive and HER2-negative breast cancer patients treated with Trastuzumab obtained from a clinical cancer registry dataset (2016) (2)
Monitoring Continuous Long-Term Outcomes in Adaptive Designs (2005) (2)
Adaptive designs for Phase II oncology trials (2015) (2)
Glioblastoma radiotherapy using Intensity modulated Radiotherapy (IMRT) or proton Radiotherapy—GRIPS Trial (Glioblastoma Radiotherapy via IMRT or Proton BeamS): a study protocol for a multicenter, prospective, open-label, randomized, two-arm, phase III study (2021) (2)
A loss-function based approach for dose selection in two-stage dose-response trials. (2001) (2)
Adverse event development in clinical oncology trials. (2016) (2)
Performance of Adaptive Designs for Single-Armed Phase II Oncology Trials (2015) (2)
FASTER and SCOTT&EVA trainings for adults with high-functioning autism spectrum disorder (ASD): study protocol for a randomized controlled trial (2021) (2)
Hypericum extract WS® 5570 has a beneficial effect in continuation treatment of recurrent depression (2005) (2)
Muscle PO2 Measurement in Critically Ill Patients and Its Correlation to Cardiac Output and Arterial PO2 (1981) (2)
Incorporating historical two‐arm data in clinical trials with binary outcome: A practical approach (2020) (2)
Improvement of functional outcome for patients with newly diagnosed grade 2 or 3 gliomas with co-deletion of 1p/19q – IMPROVE CODEL: the NOA-18 trial (2022) (1)
P05.07 Effect of Tumor-Treating Fields plus Short-Course Radiation with or without Temozolomide in Elderly Patients with Glioblastoma (GERAS Trial) (2019) (1)
Enhancing single-arm phase II trials by inclusion of matched control patients (2020) (1)
Hypericum extract WS® 5570 and paroxetine are comparably effective in continuation treatment after recovery from a moderate or severe depressive episode (2005) (1)
Integrated evaluation of targeted and non‐targeted therapies in a network meta‐analysis (2019) (1)
A note on the shape of sample size functions of optimal adaptive two-stage designs (2020) (1)
Add-on-therapy In COPD With An Herbal Drug Preparation (2010) (1)
Neoadjuvant irradiation of extremity soft tissue sarcoma with ions (Extrem-ion): study protocol for a randomized phase II pilot trial (2022) (1)
Statistical Methods for the Assessment of Clinical Relevance (2014) (1)
Optimal Designs for Multi-Arm Phase II/III Drug Development Programs (2020) (1)
An Alternative Approach for the Identification of Types in Contingency Tables (2000) (1)
Abstract 188: Safety and Efficacy of off-label Intravenous Thrombolysis in Patients With Acute Ischemic Stroke: An Observational Study From the International Safe Implementation of Treatments in Stroke (SITS) Registry (2017) (1)
Phase I study evaluating the treatment of patients with locally advanced pancreatic cancer with carbon ion radiotherapy: the PHOENIX-01 trial (2013) (1)
Using independent cross‐sectional survey data to predict post‐migration health trajectories among refugees by estimating transition probabilities and their variances (2022) (1)
WS12.2 Increased fracture rate in relation to macroscopic bone architecture in young patients with cystic fibrosis (2016) (1)
Preoperative chemoradiotherapy versus chemotherapy for adenocarcinoma of the esophagus and esophagogastric junction (AEG): systematic review with individual participant data (IPD) network meta-analysis (NMA) (2021) (1)
Optimal decision‐making in oncology development programs based on probability of success for phase III utilizing phase II/III data on response and overall survival (2020) (1)
Blinded versus Unblinded Covariate Selection in Confirmatory Survival Trials (2014) (1)
Sample Size Recalculation Based on Conditional Power (2020) (1)
[Pharmaco-economic evaluation of Ginkgo special extract EGb 761 for dementias in Austria]. (2002) (1)
[Ginkgo-special-extract EGb 761 in peripheral arterial occlusive diseases stage IIb according to Fontaine]. (1998) (1)
Definition and Rationale (2017) (1)
Adjustment for exploratory cut‐off selection in randomized clinical trials with survival endpoint (2019) (1)
Blind sample size adjustment in clinical trials: a case study. (2001) (0)
Literature review March–June 2005 (2005) (0)
Leave Me Alone With Your Symptoms! Social Exclusion at the Workplace Mediates the Relationship of Employee's Mental Illness and Sick Leave (2022) (0)
New aspects on interpretation of unspecific inhalation provocation tests in clinical trials (1994) (0)
Comments on ‘Hypothesis testing for two‐stage designs with over or under enrollment’ (2016) (0)
Weighted Composite Time-to-Event Endpoint (2017) (0)
Guideline View: Recommendations and Requirements (2017) (0)
Simulation-Based Sample Size Calculation (2020) (0)
Carbon ion radiotherapy as definitive treatment in non-metastasized pancreatic cancer: study protocol of the prospective phase II PACK-study (2020) (0)
Analysis and sample size calculation within the responder stratified exponential survival model (2022) (0)
Literature review June–September 2005 (2005) (0)
Perioperative corticosteroids for patients undergoing elective major abdominal surgery (CORPUS) (2010) (0)
Rationale and Design of GnG-Trial: A Randomized Phase-III Study to Compare Two Schedules of Gemtuzumab Ozogamicin as Adjunct to Intensive Induction Therapy and to Compare Double-Blinded Intensive Postremission Therapy with or Without Glasdegib in Older Patients with Newly Diagnosed AML (2021) (0)
Adenoid cystic Carcinoma and Carbon ion Only irradiation (ACCO): Study protocol for a prospective, open, randomized, two-armed, phase II study (2021) (0)
Optimization of the two‐stage group sequential three‐arm gold‐standard design for non‐inferiority trials (2022) (0)
Multi-Regional Trials (2020) (0)
Glioblastoma radiotherapy using Intensity modulated Radiotherapy (IMRT) or proton Radiotherapy—GRIPS Trial (Glioblastoma Radiotherapy via IMRT or Proton BeamS): a study protocol for a multicenter, prospective, open-label, randomized, two-arm, phase III study (2021) (0)
Literature review, June 2003–September 2003 (2003) (0)
Comparison of Two Groups for Normally Distributed Outcomes and Test for Difference or Superiority (2020) (0)
Improvement of functional outcome for patients with newly diagnosed grade 2 or 3 gliomas with co-deletion of 1p/19q – IMPROVE CODEL: the NOA-18 trial (2022) (0)
Hypericum extract WS 5570 in continuation treatment of recurrent depression (2010) (0)
Improving sample size recalculation in adaptive clinical trials by resampling (2021) (0)
Authors' Reply (0)
The Single-Stage Design (2017) (0)
Hamamelis vs. dexpanthenol ointment in children (2010) (0)
Concluding Remarks (2020) (0)
Other Weighted Effect Measures (2017) (0)
Disease-free survival as a surrogate for overall survival in neoadjuvant trials of gastroesophageal adenocarcinoma: Pooled analysis of individual patient data from randomized controlled trials. (2020) (0)
' s response to reviews Title : Quality of reporting of non-inferiority and equivalence randomised trials-update and extension (2012) (0)
Basic Concepts of Sample Size Recalculation (2020) (0)
Group Sequential and Adaptive Designs (2020) (0)
Literature review January‐March 2005 (2005) (0)
Sample Size Recalculation Based on Optimization (2020) (0)
Supplementary Confirmatory Analyses of the Components (2017) (0)
Letter to the editor regarding "A power study of a sequential method of p-value adjustment for correlated continuous endpoints". (1999) (0)
Interventions to reduce the incidence of surgical site infection in colorectal resections: systematic review with multicomponent network meta-analysis (INTRISSI): study protocol (2021) (0)
Subtyping of hepatocellular adenomas using Gd-EOB-DTPA: a qualitative and quantitative analysis. (2023) (0)
Monotonicity conditions for avoiding counterintuitive decisions in basket trials (2022) (0)
Regulatory and Operational Aspects (2020) (0)
Clinical Trial Examples with (Composite) Binary Endpoints (2017) (0)
S17.3: A test procedure for adaptive designs with continuous long-term endpoints (2004) (0)
IMPROVE-PD Finder: A Web-Based Platform to Search and Share Peritoneal Dialysis Biobank, Registry, and Clinical Trial Metadata. (2023) (0)
Statistical Test and Sample Size Calculation (2020) (0)
Comparison of Two Groups for Binary Outcomes and Test for Non-Inferiority (2020) (0)
Literature review September–December 2003 (2004) (0)
Ion therapy within the trimodal management of superior sulcus tumors: the INKA trial (2015) (0)
Stem cell Transplantation for Eradication of Minimal PAncreatic Cancer persisting after surgical Excision (STEM PACE Trial, ISRCTN47877138): study protocol for a phase II study (2014) (0)
Comparison of Two Groups for Binary Outcomes and Test for Difference or Superiority (2020) (0)
A comparison of methods for enriching network meta‐analyses in the absence of individual patient data (2022) (0)
Comparison of Two Groups for Time-to-Event Outcomes and Test for Difference or Superiority (2020) (0)
Comparison of More Than Two Groups and Test for Difference (2020) (0)
A non-controlled, single arm, open label, phase II study of intravenous and intratumoral administration of ParvOryx in patients with metastatic, inoperable pancreatic cancer: ParvOryx02 protocol (2017) (0)
Comparison of Two Groups for Normally Distributed Outcomes and Test for Equivalence (2020) (0)
Randomized trials in psychosomatic medicine: Practical solutions to typical design problems (1991) (0)
[The effect of low-molecular hydroxyethyl starch and dextran 60 on the muscle oxygen supply in intensive care patients]. (1982) (0)
Clinical Trial Examples (2017) (0)
Catheter Ablation of Atrial Fibrillation in Patients With Heart Failure and Preserved Ejection Fraction (2022) (0)
Descriptive Analysis of the Components (2017) (0)
Challenges of Composite Endpoints (2017) (0)
Concluding Remarks (2020) (0)
Correlation Between Test Statistics (2017) (0)
Safety of artesunate-amodiaquine combined with methylene blue or primaquine for falciparum malaria treatment in African children: A randomised controlled trial v1 (2018) (0)
Dataset for: Simulation and data-generation for random-effects network meta-analysis of binary outcome (2019) (0)
Integrated Planning of Phase II/III Drug Development Programs (2020) (0)
Automatic creation of disease models using data mining techniques on data from a clinical cancer registry (2014) (0)
Computational exploration of the interface interaction between S 100 A 8 / A 9 and GAPDH in the GAIT complex (2018) (0)
Cryoballoon-ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction (2022) (0)
Durvalumab in frail and elder patients with stage four NSCLC: Study protocol of the randomized phase II DURATION trial (2019) (0)
Guest Editor's Note: Dia Workshop on Statistical Methodology in Clinical R&D (2001) (0)
Comparison of Two Groups for Continuous and Ordered Categorical Outcomes and Test for Difference or Superiority (2020) (0)
Preface: Biom. J. Supplement 1/2004 (2004) (0)
Adjuvant intensity modulated whole-abdominal radiation therapy for high-risk patients with ovarian cancer FIGO stage III: final results of a prospective phase 2 study (2019) (0)
[New approaches to evaluation of nonspecific inhalation provocation (dose-response relationship) in the comparative evaluation of bronchial hyperreactivity within the scope of clinical trials]. (1994) (0)
Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS - a randomised controlled multicentre trial (ISRCTN30964555) (2012) (0)
Clinical Trial Examples with (Composite) Time-to-Event Endpoints (2017) (0)
Optimization of adaptive designs with respect to a performance score (2022) (0)
Comparison of Two Groups and Test for Non-Inferiority (2020) (0)
Multiple Comparisons (2020) (0)
Two-stage designs with small sample sizes (2022) (0)
Comments on “Adaptive sample size modification in clinical trials: Start small then ask for more?” (2019) (0)
To test or not to test (2012) (0)
Performance of Biomarker-Based Subgroup Selection Rules in Adaptive Enrichment Designs (2015) (0)
Safety of artesunate-amodiaquine combined with methylene blue or primaquine for falciparum malaria treatment in African children: A randomised controlled trial v2 (2018) (0)
A Comprehensive Comparison of Additional Benefit Assessment Methods Applied by Institute for Quality and Efficiency in Health Care and European Society for Medical Oncology for Time-to-Event Endpoints After Significant Phase III Trials-A Simulation Study. (2022) (0)
Optimal unplanned design modification in adaptive two‐stage trials (2022) (0)
blindrecalc - An R Package for Blinded Sample Size Recalculation (2022) (0)
Literature review, December 2003‐March 2004 (2004) (0)
Comparison of Two Groups for Normally Distributed Outcomes and Test for Non-Inferiority (2020) (0)
Determination of power and sample size for proving equivalence based on the ratio of two means for normally distributed data (1998) (0)
Related Software Code (2017) (0)
Literature Review June‐September 2004 (2004) (0)
An adaptive design for early clinical development including interim decision for single‐arm trial with external controls or randomized trial (2022) (0)
Cluster-Randomized Trials (2020) (0)
Literature Review March–June 2004 (2004) (0)
Phase I/II trial evaluating carbon ion radiotherapy for the treatment of recurrent rectal cancer: the PANDORA-01 trial (2012) (0)
Weighted Composite Binary Endpoint (2017) (0)
Menthacarin for the Treatment of Epigastric Pain Syndrome (EPS) and Postprandial Distress Syndrome (PDS): Data of a placebo-controlled trial revisited (2015) (0)
A comparison of group sequential and fixed sample size designs for bioequivalence trials with highly variable drugs (2018) (0)
Correction to: Endovascular stroke treatment’s impact on malignant type of edema (ESTIMATE) (2020) (0)
Adaptive Designs and Multiple Testing Prozedures (2014) (0)
Fostering efficacy of anti-PD-1-treatment: Nivolumab plus radiotherapy in advanced non-small cell lung cancer - study protocol of the FORCE trial (2019) (0)
Comparison of Three Groups in the Gold Standard Non-Inferiority Design (2020) (0)
Internal Pilot Study Designs (2020) (0)
A General Approach for Controlling the Type I Error Rate for Blinded Sample Size Recalculation (2020) (0)
Leveraging Markov Models to Compute Prevalence Estimates for a Regional Breast Cancer Registry (2013) (0)
Literature review September–December 2004 (2005) (0)
The potential of adaptive designs. (2001) (0)

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