Melissa J. Moore

Q: What Schools Are Affiliated With Melissa J. Moore

Melissa J. Moore is affiliated with the following schools: Massachusetts Institute of Technology, University of Massachusetts Medical School, William & Mary, Brandeis University

Melissa J. Moore's AcademicInfluence.com Rankings

Melissa J. Moore

Biology

#3388

World Rank

#5192

Historical Rank

#1379

USA Rank

Biochemistry

#695

World Rank

#795

Historical Rank

#213

USA Rank

biology Degrees

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Biology

Why Is Melissa J. Moore Influential?

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According to Wikipedia, Melissa J. Moore is an American biochemist who focuses on RNA. She was the Chief Scientific Officer of Moderna from 2016-2023, where her team contributed to the development of the Moderna COVID-19 vaccine.

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Melissa J. Moore's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Pre-mRNA splicing: awash in a sea of proteins. (2003) (1046)
From Birth to Death: The Complex Lives of Eukaryotic mRNAs (2005) (1037)
The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions (2000) (940)
Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals (2016) (891)
Pre-mRNA Processing Reaches Back toTranscription and Ahead to Translation (2009) (854)
A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes (2013) (818)
The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense‐mediated mRNA decay (2001) (796)
How introns influence and enhance eukaryotic gene expression. (2003) (694)
Mutations in the Profilin 1 Gene Cause Familial Amyotrophic Lateral Sclerosis (2012) (547)
The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function (2008) (471)
Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites. (1992) (431)
Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes*♦ (2010) (408)
A quantitative analysis of intron effects on mammalian gene expression. (2003) (408)
Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. (2004) (399)
13 Splicing of Precursors to mRNA by the Spliceosome (1993) (387)
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (2002) (364)
Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. (2000) (350)
A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation (2016) (336)
Human polymorphism at microRNAs and microRNA target sites. (2013) (330)
Nuclear Envelope Budding Enables Large Ribonucleoprotein Particle Export during Synaptic Wnt Signaling (2012) (313)
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. (2013) (313)
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines (2019) (311)
The EJC Factor eIF4AIII Modulates Synaptic Strength and Neuronal Protein Expression (2007) (310)
The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion. (2015) (302)
Post-transcriptional regulation of gene expression in innate immunity (2014) (287)
The ever-increasing complexities of the exon junction complex. (2004) (283)
The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus (2012) (277)
eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay (2004) (275)
Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing (1993) (251)
The spliceosome: a flexible, reversible macromolecular machine. (2012) (226)
Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides (2015) (219)
Ordered and Dynamic Assembly of Single Spliceosomes (2011) (216)
Branch nucleophile selection in pre-mRNA splicing: evidence for the bulged duplex model. (1994) (215)
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. (2005) (212)
mRNA structure regulates protein expression through changes in functional half-life (2019) (211)
Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607 (1991) (189)
A convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decay. (2009) (170)
Redefining the Translational Status of 80S Monosomes (2016) (165)
CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion (2017) (162)
The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing*S⃞ (2008) (162)
A late-acting quality control process for mature eukaryotic rRNAs. (2006) (148)
5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly. (2002) (143)
Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis (2014) (141)
Joining of RNAs by splinted ligation. (2000) (140)
DEBrowser: interactive differential expression analysis and visualization tool for count data (2018) (136)
Precursor RNAs harboring nonsense codons accumulate near the site of transcription. (2001) (135)
Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope. (2013) (132)
The nuclear nurture and cytoplasmic nature of localized mRNPs. (2007) (131)
Staufen1 senses overall transcript secondary structure to regulate translation (2013) (127)
Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations (2013) (121)
Introns in UTRs: Why we should stop ignoring them (2012) (116)
The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes. (1999) (114)
RNAi Modulation of Placental sFLT1 for the Treatment of Preeclampsia. (2018) (101)
Intron recognition comes of AGe (2000) (101)
Visualizing the splicing of single pre-mRNA molecules in whole cell extract. (2007) (100)
Meayamycin inhibits pre–messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells (2009) (96)
Use of a site-directed triple mutant to trap intermediates: demonstration that the flavin C(4a)-thiol adduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase. (1990) (95)
Interactions between eIF4AI and its accessory factors eIF4B and eIF4H. (2008) (95)
Organomercurial lyase and mercuric ion reductase: nature's mercury detoxification catalysts (1990) (91)
The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site. (1999) (88)
Spliceosome assembly and composition. (2007) (87)
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo (2018) (86)
Three-dimensional structure of C complex spliceosomes by electron microscopy (2004) (83)
Nuclear RNA Turnover (2002) (82)
Bimolecular exon ligation by the human spliceosome. (1997) (82)
Molecular basis of bacterial resistance to organomercurial and inorganic mercuric salts (1988) (81)
Evidence for the participation of Cys558 and Cys559 at the active site of mercuric reductase. (1989) (81)
Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes (2011) (77)
RIPiT-Seq: a high-throughput approach for footprinting RNA:protein complexes. (2014) (76)
Alternative spliceosome assembly pathways revealed by single-molecule fluorescence microscopy. (2013) (74)
Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay. (2006) (73)
The spliceosome: disorder and dynamics defined. (2014) (73)
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity. (2021) (70)
RNA metabolism and the pathogenesis of motor neuron diseases (2010) (64)
Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5′ splice site and branch site (2013) (63)
MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct (2018) (62)
Evidence for a linear search in bimolecular 3' splice site AG selection. (2000) (56)
Active site of mercuric reductase resides at the subunit interface and requires Cys135 and Cys140 from one subunit and Cys558 and Cys559 from the adjacent subunit: evidence from in vivo and in vitro heterodimer formation. (1990) (55)
Mutagenesis of the N- and C-terminal cysteine pairs of Tn501 mercuric ion reductase: consequences for bacterial detoxification of mercurials. (1989) (55)
Capturing splicing complexes to study structure and mechanism. (2002) (52)
An optimized kit-free method for making strand-specific deep sequencing libraries from RNA fragments (2014) (52)
Stress and Chronic Illness: the Case of Diabetes (2011) (49)
Higher-Order Organization Principles of Pre-translational mRNPs (2018) (46)
C-terminal cysteines of Tn501 mercuric ion reductase. (1992) (40)
Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes (2014) (40)
ASPeak: an abundance sensitive peak detection algorithm for RIP-Seq (2013) (40)
The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus (2012) (38)
Extrinsic and intrinsic factors impacting on the retention of older rural healthcare workers in the north Victorian public sector: a qualitative study. (2014) (37)
The Human Nucleolar Protein FTSJ3 Associates with NIP7 and Functions in Pre-rRNA Processing (2011) (36)
Workforce Crisis in Residential Aged Care: Insights from Rural, Older Workers (2017) (36)
Novel HOX, POU and FKH genes expressed during bFGF-induced mesodermal differentiation in Xenopus. (1994) (36)
The three-dimensional arcitecture of the EJC core. (2006) (35)
Single molecule analysis reveals reversible and irreversible steps during spliceosome activation (2016) (35)
FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia (2017) (34)
Effective Community-Based Physical Activity Interventions for Older Adults Living in Rural and Regional Areas: A Systematic Review. (2016) (33)
Spliceosomes (2015) (31)
New insights into the spliceosome by single molecule fluorescence microscopy. (2011) (31)
Transcriptome-wide Interrogation of the Functional Intronome by Spliceosome Profiling (2017) (30)
Measuring Motivation for Physical Activity: An Exploratory Study of PALMS -The Physical Activity and Leisure Motivation Scale (2012) (30)
Assessing long-distance RNA sequence connectivity via RNA-templated DNA–DNA ligation (2015) (28)
Better conditions for mammalian in vitro splicing provided by acetate and glutamate as potassium counterions. (2000) (27)
A Qualitative Study of the Achievement Goals of Recreational Exercise Participants. (2008) (26)
Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin. (2018) (26)
Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation. (2004) (24)
ASC1 and RPS3: new actors in 18S nonfunctional rRNA decay (2017) (24)
Association of ribosomal proteins with nascent transcripts in S. cerevisiae. (2005) (23)
Joining RNA molecules with T4 DNA ligase. (1999) (23)
Domain Analysis of Human U5 RNA CAP TRIMETHYLATION, PROTEIN BINDING, AND SPLICEOSOME ASSEMBLY* (1996) (23)
Purification, crystallization, and preliminary x-ray diffraction studies of the flavoenzyme mercuric ion reductase from Bacillus sp. strain RC607. (1989) (23)
Defining piRNA primary transcripts (2013) (21)
Synergistic assembly of human pre-spliceosomes across introns and exons (2018) (21)
Location of ubiquinone-10 (CoQ-10) in phospholipid vesicles. (1985) (20)
TAPping into mRNA Export (2001) (19)
Bimolecular exon ligation by the human spliceosome bypasses early 3' splice site AG recognition and requires NTP hydrolysis. (2000) (18)
A common class of transcripts with 5′-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification (2016) (14)
No End to Nonsense (2002) (14)
Challenges to the Recruitment and Retention of Volunteers in Traditional Nonprofit Organizations: A Case Study of Australian Meals on Wheels (2018) (12)
34: LincRNA-Cox2 is a long noncoding RNA induced by TLRs that mediates both activation and repression of immune response genes (2013) (12)
RNA events. No end to nonsense. (2002) (11)
Free circular introns with an unusual branchpoint in neuronal projections (2019) (9)
Nurturing spiritual well‐being among older people in Australia: Drawing on Indigenous and non‐Indigenous way of knowing (2017) (9)
Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides (2016) (8)
Incorporation of Modified Nucleotides into RNA for Studies on RNA Structure, Function and Intermolecular Interactions (1998) (8)
Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways (2021) (8)
An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts (2022) (7)
Fully automated peptide radiolabeling from [18F]fluoride (2019) (6)
Physical Activity and Leisure Motivation Scale (2015) (6)
Cell biology. TAPping into mRNA export. (2001) (5)
Tri-Partite Assay for Studying Exon Ligation by the ai5γ Group II Intron† (2000) (4)
The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5 9 splice site (1999) (4)
Nuclear Envelope Budding Enables Large Ribonucleoprotein Particle Export during Synaptic Wnt Signaling (2012) (3)
DNA-drug interactions *1The crystal structure of d(CGATCG) complexed with daunomycin (1989) (3)
Conserved cysteine pairs of mercuric ion reductase: an investigation of function via site-directed mutagenesis (1987) (3)
The penultimate cysteines in mercuric reductase aid in the reduction of mercury (1987) (2)
The Three-dimensional Arc h itecture of the EJC Core (2006) (2)
Organomercurial Lyase and Mercuric Ion Reductase: Nature′s Mercury Detoxification Catalysts (1990) (2)
Reclaiming Futures: Using communication to drive community and systems change (2011) (2)
Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1 (2022) (2)
Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved AS-NMD pathways (2019) (2)
Researching the Effectiveness of a Decision Support Tool for Adult Consumers With Mental Health Needs and Their Care Managers (2019) (2)
Reduced forms of native mercuric reductase and their reactions with mercuric compounds - activity vs inhibition (1987) (1)
Advanced 3D Analysis and Optimization of Single-Molecule FISH in Drosophila Muscle. (2018) (1)
Twenty years of technology (2015) (1)
Redefining the Translational Status of 80 S Monosomes Graphical (2016) (1)
Author response: Assessing long-distance RNA sequence connectivity via RNA-templated DNA–DNA ligation (2014) (1)
Translation-dependent and independent mRNA decay occur through mutually exclusive pathways that are defined by ribosome density during T Cell activation (2020) (1)
Purification , Crystallization , and Preliminary X-ray Diffraction Studies of the Flavoenzyme Mercuric Ion Reductase from Bacillus sp . Strain RC 607 * (2001) (1)
Single Molecule Approaches in RNA-Protein Interactions. (2016) (1)
Leadership Under Fire: A Phenomenological Study of Senior Administrator’s Perceived Leadership Identity and Crisis Response at Higher Education Institutions in the United States (2018) (1)
Physical activity and depression among overweight women with Type 2 Diabetes Mellitus (2011) (1)
Does Shared Decision Making Improve Care at Community Mental Health Clinics? (2019) (1)
DEBrowser: interactive differential expression analysis and visualization tool for count data (2019) (0)
CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion (2017) (0)
Direct Observation of pre-mRNA Arrangements During Spliceosome Assembly Using Single Molecule FRET (2011) (0)
Reviewer ' s report Title : Differential expression of THOC 1 and ALY mRNP biogenesis / export factors in human cancers (0)
Turning on the Spliceosome (2012) (0)
Functional characterization of proteins NIP7 and FTSJ3 in pre-rRNA processing in human cells (2012) (0)
Tri-partite assay for studying exon ligation by the ai5gamma group II intron. (2000) (0)
Single-molecule FISH in Drosophila muscle reveals location dependent mRNA composition of megaRNPs (2017) (0)
Dynamic and Ordered Assembly of Single Spliceosomes (2011) (0)
Deep sequencing of pre-translational mRNPs reveals hidden flux through evolutionarily conserved alternative splicing nonsense-mediated decay pathways (2021) (0)
Minisymposium: Molecular Motors: Stopped or Slowed by Their Tracks (2012) (0)
function of the exon junction complex Splicing enhances translation in mammalian cells: an additional (2006) (0)
Investigating Functional Roles of RPS3 in RNA Damage (2015) (0)
The three-dimensional structure of mercuric ion reductase from Bacillus sp. strain RC607 (1991) (0)
FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia (2017) (0)
Author response: Single molecule analysis reveals reversible and irreversible steps during spliceosome activation (2016) (0)
Cell Penetrating or “ Trojan ” Peptides (2006) (0)
Functional mRNA delivery to hematopoietic stem and progenitor cells in vivo (2022) (0)
Catalytic mercury reduction by the detoxification enzyme, mercuric ion reductase, requires four active site cysteines located at the subunit interface (1989) (0)
ASSEMBLY BINDING, AND SPLICEOSOME TRIMETHYLATION, PROTEIN Domain Analysis of Human U5 RNA CAP Molecular Genetics: Nucleic Acids, Protein Synthesis, and (2014) (0)
Table 1 Effects of Community-Based Interventions Designed to Promote Physical Activity ( PA ) Among Rural / Regional Individuals Aged 65 Years or Older on Physical Activity Patterns , Physical Activity Behaviors , and Physical Function (2016) (0)
Into the CoSMoS: Single Molecule Analysis of Spliceosome Assembly and Activation (2012) (0)
' s report Title : Differential expression of THOC 1 and ALY mRNP biogenesis / export factors in human cancers Version : 1 Date : 17 May 2010 (0)
The secret of excellence in student services - a case example of cross-institution collaboration and cooperation (2011) (0)
Promoting Physical Activity for the Management of Obesity (2014) (0)
Effects of resistance training followed by home-based training of psychological well-being in people with type 2 diabetes (2009) (0)
MassTERi: Promoting Translational Research and Entrepreneurship at the University of Massachusetts Medical School (2014) (0)
63 Transcriptome wide profiling of mRNA 3′-ends in preeclampsia using PAS-SEQ (2016) (0)
Mutagenesis of paired cysteine residues in the disulphide-containing flavoprotein mercuric ion reductase from mercury-resistant bacteria. (1988) (0)
Author response: Synergistic assembly of human pre-spliceosomes across introns and exons (2018) (0)
Phase II - Procurement of State of the Art Research Equipment to Support Faculty Members with the RNA Therapeutics Institute, a component of the Advanced Therapeutics Cluster at the University of Massachusetts Medical School (2011) (0)
3 RIPiT-Seq: A high-throughput approach for footprinting RNA:protein (2013) (0)
ON THE MECHANISM OF MERCURIC REDUCTASE: AN ALTERNATING SITES HYPOTHESIS (1991) (0)
Corrigendum: ASC1 and RPS3: new actors in 18S nonfunctional rRNA decay. (2018) (0)

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Other Resources About Melissa J. Moore

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What Schools Are Affiliated With Melissa J. Moore?

Melissa J. Moore is affiliated with the following schools: