Melvin E. Andersen
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Why Is Melvin E. Andersen Influential?
(Suggest an Edit or Addition)Melvin E. Andersen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Toxicity Testing in the 21st Century: A Vision and a Strategy (2010) (1138)
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013) (1068)
- A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. (1984) (692)
- Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. (1987) (672)
- Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion (2007) (507)
- Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. (1989) (485)
- Inhaled Carbon Nanotubes Reach the Sub-Pleural Tissue in Mice (2009) (440)
- Human exposure and internal dose assessments of acrylamide in food. (2005) (366)
- Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment. (2012) (352)
- Organotypic liver culture models: Meeting current challenges in toxicity testing (2012) (315)
- ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. (2010) (299)
- Toxicity testing in the 21st century: bringing the vision to life. (2009) (283)
- Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action. (2008) (277)
- Risk Assessment Extrapolations and Physiological Modeling (1985) (243)
- Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. (2010) (238)
- Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework (2013) (209)
- Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results (2012) (195)
- Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing (2015) (190)
- A systems biology perspective on Nrf2-mediated antioxidant response. (2010) (189)
- Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways (2011) (188)
- Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment (2009) (186)
- A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish. (1990) (186)
- A physiologically based simulation approach for determining metabolic constants from gas uptake data. (1986) (183)
- Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys--probing the determinants of long plasma half-lives. (2006) (179)
- Development of a physiologically based pharmacokinetic model for chloroform. (1990) (173)
- Dose-dependent transitions in mechanisms of toxicity. (2004) (170)
- Dose-dependent transitions in mechanisms of toxicity: case studies. (2004) (169)
- Toxicokinetic modeling and its applications in chemical risk assessment. (2003) (162)
- Metabolism of inhaled dihalomethanes in vivo: differentiation of kinetic constants for two independent pathways. (1986) (162)
- A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure. (2007) (160)
- Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese. (1999) (155)
- The acute toxicity of perfluorooctanoic and perfluorodecanoic acids in male rats and effects on tissue fatty acids. (1983) (153)
- Physiologically-Based Pharmacokinetic Modeling* (1994) (146)
- Quantitative interpretation of human biomonitoring data. (2008) (145)
- Temporal concordance between apical and transcriptional points of departure for chemical risk assessment. (2013) (144)
- Ultrasensitive response motifs: basic amplifiers in molecular signalling networks (2013) (143)
- Adipose Deficiency of Nrf2 in ob/ob Mice Results in Severe Metabolic Syndrome (2013) (142)
- A physiologically based toxicokinetic description of the metabolism of inhaled gases and vapors: analysis at steady state. (1981) (140)
- Toxicity testing in the 21st century: progress in the past decade and future perspectives (2019) (139)
- Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK) (2015) (137)
- Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. (1989) (136)
- A comprehensive statistical analysis of predicting in vivo hazard using high-throughput in vitro screening. (2012) (133)
- Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans. (1991) (132)
- Low-Level Arsenic Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells: Involvement of Cellular Adaptive Response to Oxidative Stress (2010) (131)
- Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation. (2007) (131)
- Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment. (1993) (129)
- A deterministic map of Waddington's epigenetic landscape for cell fate specification (2011) (127)
- An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy. (2016) (127)
- GlutathioneS-Transferase-Mediated Mutagenicity of Trihalomethanes inSalmonella typhimurium:Contrasting Results with Bromodichloromethane and Chloroform (1997) (126)
- Dermal absorption of organic chemical vapors in rats and humans. (1990) (125)
- Determination of the kinetic constants for metabolism of inhaled toxicants in vivo using gas uptake measurements. (1980) (124)
- Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling. (1990) (116)
- Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment. (2015) (115)
- Relative impact of incorporating pharmacokinetics on predicting in vivo hazard and mode of action from high-throughput in vitro toxicity assays. (2013) (114)
- Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment. (2011) (114)
- Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound. (2010) (113)
- Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. (2012) (112)
- Development of Pbpk Models for Pfoa and Pfos for Human Pregnancy and Lactation Life Stages (2013) (106)
- Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods. (1987) (104)
- Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene. (1995) (103)
- New directions in toxicity testing. (2011) (102)
- Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model. (2001) (101)
- A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. (1990) (100)
- Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk. (1996) (100)
- Linear low-dose extrapolation for noncancer health effects is the exception, not the rule (2011) (99)
- Physiologically Based Pharmacokinetic Modeling : Science and Applications (2005) (98)
- A physiologically based pharmacokinetic model for inhaled carbon tetrachloride. (1988) (98)
- Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse. (1991) (98)
- Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model. (2011) (97)
- Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: describing manganese homeostasis during development. (2011) (96)
- Sensitivity analysis of a physiological model for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): assessing the impact of specific model parameters on sequestration in liver and fat in the rat. (2000) (96)
- In vitro human tissue models in risk assessment: report of a consensus-building workshop. (2001) (96)
- A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity. (1999) (93)
- Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat. (2008) (92)
- 17 – Physiologically Based Pharmacokinetic Modeling of Chemical Mixtures (1994) (91)
- A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment. (2001) (91)
- Development of physiologically based pharmacokinetic and physiologically based pharmacodynamic models for applications in toxicology and risk assessment. (1995) (91)
- A Framework for the Next Generation of Risk Science (2014) (89)
- Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene chloride: implications for risk assessment. (1988) (89)
- Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation. (1997) (88)
- A physiological pharmacokinetic model for dermal absorption of vapors in the rat. (1986) (88)
- A map of the PPARα transcription regulatory network for primary human hepatocytes. (2014) (88)
- Saturable metabolism and its relationship to toxicity. (1981) (87)
- Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone. (2001) (87)
- Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. (1990) (86)
- Dose Response Relationship in Anti-Stress Gene Regulatory Networks (2006) (86)
- In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI (2012) (84)
- Physiological modelling of organic compounds. (1991) (84)
- Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropyfluorophosphate (1990) (84)
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013) (84)
- The vision of toxicity testing in the 21st century: moving from discussion to action. (2010) (83)
- A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice. (1988) (83)
- PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF STYRENE AND STYRENE OXIDE RESPIRATORY-TRACT DOSIMETRY IN RODENTS AND HUMANS (2002) (83)
- Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposure. (1988) (82)
- Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response. (2011) (82)
- A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment. (1992) (82)
- A physiologically based pharmacokinetic model for nicotine disposition in the Sprague-Dawley rat. (1992) (81)
- Evidence that atrazine and diaminochlorotriazine inhibit the estrogen/progesterone induced surge of luteinizing hormone in female Sprague-Dawley rats without changing estrogen receptor action. (2004) (80)
- Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study. (2012) (78)
- Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposures with a PBPK model. (2009) (78)
- Development of a physiologically based pharmacokinetic model for risk assessment with 1,4-dioxane. (1990) (78)
- Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function (2016) (78)
- Long Isoforms of NRF1 Contribute to Arsenic-Induced Antioxidant Response in Human Keratinocytes (2010) (78)
- Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages. (2009) (77)
- Modeling the tissue solubilities and metabolic rate constant (Vmax) of halogenated methanes, ethanes, and ethylenes. (1988) (77)
- Physiologically based pharmacokinetic model for the inhibition of acetylcholinesterase by organophosphate esters. (1994) (77)
- Predicting cancer risk from vinyl chloride exposure with a physiologically based pharmacokinetic model. (1996) (77)
- The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions (2016) (75)
- Pharmacokinetics of tetrachloroethylene. (1988) (74)
- Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury (2010) (74)
- Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats. (2001) (73)
- In vivo metabolic interactions of benzene and toluene. (1990) (73)
- Biologically based pharmacodynamic models: tools for toxicological research and risk assessment. (1991) (72)
- An Analysis of N-Acetylcysteine Treatment for Acetaminophen Overdose Using a Systems Model of Drug-Induced Liver Injury (2012) (72)
- The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene. (2007) (71)
- Adverse Outcome Pathways can drive non-animal approaches for safety assessment (2015) (71)
- Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)). (2007) (70)
- Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis. (2008) (69)
- Assessing the relevance of in vitro measures of phthalate inhibition of steroidogenesis for in vivo response. (2010) (69)
- Applying simulation modeling to problems in toxicology and risk assessment--a short perspective. (1995) (69)
- In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat. (2012) (68)
- Non-monotonic dose-response relationship in steroid hormone receptor-mediated gene expression. (2007) (68)
- Toxic effects of nonadecafluoro-n-decanoic acid in rats. (1986) (67)
- Application of pharmacokinetic data to the risk assessment of inhaled manganese. (2006) (67)
- Adjusting exposure limits for long and short exposure periods using a physiological pharmacokinetic model. (1987) (66)
- Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models. (2011) (65)
- Application of a physiologically based pharmacokinetic model for isopropanol in the derivation of a reference dose and reference concentration. (2002) (65)
- Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study (2011) (65)
- Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid. (2008) (65)
- Negative selection in hepatic tumor promotion in relation to cancer risk assessment. (1995) (64)
- Inhalation pharmacokinetics: evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood:inhaled air concentration ratios. (1984) (63)
- Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to di-n-butylphthalate: evaluation with a PBPK model. (2008) (63)
- A Physiologically Based Description of Ethylene Oxide Dosimetry in the Rat (1992) (63)
- Gas Uptake Inhalation Techniques and the Rates of Metabolism of Chloromethanes, Chloroethanes, and Chloroethylenes in the Rat (1990) (63)
- A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: tissue distribution and CYP1A induction. (1993) (63)
- Association between Arsenic Suppression of Adipogenesis and Induction of CHOP10 via the Endoplasmic Reticulum Stress Response (2012) (62)
- Physiologically based modeling of vinyl acetate uptake, metabolism, and intracellular pH changes in the rat nasal cavity. (1997) (62)
- A physiologically based pharmacokinetic model for retinoic acid and its metabolites. (1997) (61)
- Pathways of Toxicity. (2014) (60)
- Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity. (2016) (60)
- Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses. (2009) (59)
- Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage. (2012) (59)
- Long‐Term Stability of Primary Rat Hepatocytes in Micropatterned Cocultures (2013) (59)
- A Physiologically Based Pharmacokinetic Model for Acrylamide and Its Metabolite, Glycidamide, in the Rat (2003) (58)
- Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model. (2012) (58)
- Characterization of the Pharmacokinetics of Gasoline Using PBPK Modeling with a Complex Mixtures Chemical Lumping Approach (2003) (57)
- Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells. (2012) (57)
- Hormesis and Adaptive Cellular Control Systems (2008) (56)
- Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model. (2012) (56)
- Cross-Regulations among NRFs and KEAP1 and Effects of their Silencing on Arsenic-Induced Antioxidant Response and Cytotoxicity in Human Keratinocytes (2012) (56)
- Enhancing and Extending Biological Performance and Resilience (2018) (55)
- Pharmacokinetics of [125I]-2-iodo-3,7,8-trichlorodibenzo-p-dioxin in mice: analysis with a physiological modeling approach. (1990) (55)
- CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion. (2015) (55)
- In silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane. (2002) (55)
- Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise. (2003) (54)
- A mechanistic redefinition of adverse effects - a key step in the toxicity testing paradigm shift. (2010) (54)
- The Human Toxome Project (2015) (54)
- Pathological and hepatic ultrastructural effects of a single dose of perfluoro-n-decanoic acid in the rat, hamster, mouse, and guinea pig. (1987) (54)
- Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment. (2015) (53)
- Dermal absorption and penetration of jet fuel components in humans. (2006) (53)
- Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: an example with acrylic acid. (2000) (53)
- The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative (2007) (52)
- Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals. (2009) (52)
- Toxicology of cyclotrimethylenetrinitramine: distribution and metabolism in the rat and the miniature swine. (1977) (52)
- Lessons learned in applying the U.S. EPA proposed cancer guidelines to specific compounds. (2000) (52)
- Computational Systems Biology and Dose-Response Modeling in Relation to New Directions in Toxicity Testing (2010) (52)
- Detection and localization of an estrogen receptor beta splice variant protein (ERβ2) in the adult female rat forebrain and midbrain regions (2007) (51)
- A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s. (1997) (51)
- Determining kinetic constants of chlorinated ethane metabolism in the rat from rates of exhalation. (1989) (51)
- The Future of Toxicity Testing (2010) (50)
- Evidence-based toxicology for the 21st century: opportunities and challenges. (2013) (50)
- Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches (2012) (50)
- Molecular Signaling Network Motifs Provide a Mechanistic Basis for Cellular Threshold Responses (2014) (50)
- Pharmacokinetic Modeling of Disposition and Time-Course Studies With [ 14 C]Atrazine (2003) (49)
- Tissue dosimetry, pharmacokinetic modeling, and interspecies scaling factors. (1995) (49)
- Applications of physiologic pharmacokinetic modeling in carcinogenic risk assessment. (1994) (48)
- Pharmacokinetics, biochemical mechanism and mutation accumulation: a comprehensive model of chemical carcinogenesis. (1988) (47)
- Manganese tissue dosimetry in rats and monkeys: accounting for dietary and inhaled Mn with physiologically based pharmacokinetic modeling. (2009) (47)
- Evaluating transport of manganese from olfactory mucosa to striatum by pharmacokinetic modeling. (2007) (47)
- Physiologically based pharmacokinetic analyses of simple mixtures. (1994) (47)
- The use of inhalation techniques to assess the kinetic constants of 1,1-dichloroethylene metabolism. (1979) (47)
- Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage (2014) (46)
- Physiologically based pharmacokinetics and cancer risk assessment. (1994) (46)
- New directions in incidence-dose modeling. (2005) (46)
- The significance of multiple detoxification pathways for reactive metabolites in the toxicity of 1,1-dichloroethylene. (1980) (45)
- Assessing interaction thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling (2001) (45)
- Pharmacokinetic Modeling of Manganese in the Rat IV: Assessing Factors that Contribute to Brain Accumulation During Inhalation Exposure (2008) (45)
- Preclinical Development Handbook: ADME and Biopharmaceutical Properties (2007) (45)
- Dosimetric adjustment factors for methyl methacrylate derived from a steady-state analysis of a physiologically based clearance-extraction model. (1999) (45)
- Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure. (2010) (44)
- Physiologically based pharmacokinetic/toxicokinetic modeling. (2012) (44)
- Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?". (2011) (44)
- Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats. (2006) (44)
- Evaluation of Physiologically Based Pharmacokinetic Models in Risk Assessment: An Example with Perchloroethylene (2005) (44)
- Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics? (2013) (44)
- Hepatic foci in rats after diethylnitrosamine initiation and 2,3,7,8-tetrachlorodibenzo-p-dioxin promotion: evaluation of a quantitative two-cell model and of CYP 1A1/1A2 as a dosimeter. (1997) (42)
- Endocrine active compounds: from biology to dose response assessment. (1998) (42)
- Physiologically based estimation of in vivo rates of bromodichloromethane metabolism. (1997) (41)
- Mechanistic approaches for mixture risk assessments-present capabilities with simple mixtures and future directions. (2004) (41)
- A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2010) (41)
- Evaluation of Potential Toxicity from Co-Exposure to Three CNS Depressants (Toluene, Ethylbenzene, and Xylene) Under Resting and Working Conditions Using PBPK Modeling (2005) (41)
- Mode of action and tissue dosimetry in current and future risk assessments. (2001) (40)
- Iodoacetic acid activates Nrf2-mediated antioxidant response in vitro and in vivo. (2014) (40)
- In vitro intestinal and hepatic metabolism of Di(2-ethylhexyl) phthalate (DEHP) in human and rat. (2013) (39)
- Physiological pharmacokinetics and cancer risk assessment. (1993) (39)
- Physiologically-Based Pharmacokinetic Modeling and Bioactivation of Xenobiotics (1994) (39)
- Toxicokinetics and Physiologically Based Toxicokinetics in Toxicology and Risk Assessment (2003) (39)
- Physiologically based pharmacokinetic model for vinylidene chloride. (1988) (39)
- Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology. (2004) (39)
- Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans. (2008) (39)
- Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models. (2003) (39)
- Kinetic characterization of CYP2E1 inhibition in vivo and in vitro by the chloroethylenes (1998) (39)
- Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats. (2009) (38)
- The effect of pregnancy on renal clearance of boron in rats given boric acid orally. (2001) (38)
- A biologically based dose-response model for dietary iodide and the hypothalamic-pituitary-thyroid axis in the adult rat: evaluation of iodide deficiency. (2008) (38)
- Mutagenicity oftrans-anethole, estragole, eugenol, and safrole in the amesSalmonella typhimurium assay (1982) (38)
- Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression (2019) (38)
- Application of biologically based computer modeling to simple or complex mixtures. (2002) (37)
- Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone (1996) (36)
- Harmonization: Developing Consistent Guidelines for Applying Mode of Action and Dosimetry Information to Cancer and Noncancer Risk Assessment (1998) (36)
- Oral toxicity of 1,1-Dichloroethylene in the rat: Effects of sex, age, and fasting (1977) (36)
- Pharmacokinetic Modeling of Manganese. I. Dose Dependencies of Uptake and Elimination (2007) (36)
- Using human data to protect the public's health. (2001) (36)
- 1,1-Dichloroethylene nephrotoxicity in the rat. (1978) (36)
- Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate. (1990) (36)
- Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans. (2006) (36)
- Pharmacokinetic Modeling of Manganese. III. Physiological Approaches Accounting for Background and Tracer Kinetics (2007) (35)
- Metabolism of inhaled brominated hydrocarbons: validation of gas uptake results by determination of a stable metabolite. (1982) (35)
- Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages. (2014) (35)
- Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo. (1994) (35)
- A physiologically based dosimetry description of acrylonitrile and cyanoethylene oxide in the rat. (1995) (34)
- Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling (2004) (34)
- Physiologically based pharmacokinetic (PBPK) models for nasal tissue dosimetry of organic esters: assessing the state-of-knowledge and risk assessment applications with methyl methacrylate and vinyl acetate. (2002) (34)
- Quantitative identification of atrazine and its chlorinated metabolites in plasma. (2003) (34)
- Dose-response modeling in reproductive toxicology in the systems biology era. (2005) (34)
- Divergent Effects of Sulforaphane on Basal and Glucose-Stimulated Insulin Secretion in β-Cells: Role of Reactive Oxygen Species and Induction of Endogenous Antioxidants (2013) (33)
- Mutagenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin and perfluoro-n-decanoic acid in L5178Y mouse-lymphoma cells. (1982) (33)
- Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures? (2008) (33)
- Biologically motivated models for chemical risk assessment. (1989) (33)
- Applying Mode-of-Action and Pharmacokinetic Considerations in Contemporary Cancer Risk Assessments: An Example with Trichloroethylene (2004) (33)
- Physiologically Based Pharmacokinetic and Toxicokinetic Models (2007) (33)
- Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics? (2015) (33)
- Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes. (2013) (33)
- Saturable metabolism and the acute toxicity of 1,1-dichloroethylene. (1979) (33)
- Accelerating the Development of 21st-Century Toxicology: Outcome of a Human Toxicology Project Consortium Workshop (2011) (33)
- A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development. (2013) (32)
- Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin. (2013) (32)
- Bayesian Estimation of Pharmacokinetic and Pharmacodynamic Parameters in a Mode‐of‐Action‐Based Cancer Risk Assessment for Chloroform (2007) (32)
- A physiologically based pharmacokinetic description of the oral uptake, tissue dosimetry, and rates of metabolism of bromodichloromethane in the male rat. (1998) (32)
- Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane. (2002) (32)
- Oral absorption and oxidative metabolism of atrazine in rats evaluated by physiological modeling approaches. (2007) (32)
- Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total T4 and TSH (2009) (32)
- A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans. (1983) (31)
- Dose-response characteristics of uterine responses in rats exposed to estrogen agonists. (1998) (31)
- A hybrid CFD-PBPK model for naphthalene in rat and human with IVIVE for nasal tissue metabolism and cross-species dosimetry (2014) (31)
- Mode-of-action-based dosimeters for interspecies extrapolation of vinyl acetate inhalation risk. (2001) (31)
- Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells. (2016) (31)
- On the incorporation of chemical-specific information in risk assessment. (2008) (31)
- Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling. (2008) (31)
- Organic extract contaminants from drinking water activate Nrf2-mediated antioxidant response in a human cell line. (2013) (31)
- Molecular circuits, biological switches, and nonlinear dose-response relationships. (2002) (31)
- Evaluating Pharmacokinetic and Pharmacodynamic Interactions with Computational Models in Supporting Cumulative Risk Assessment (2011) (30)
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- Potentiation of 2,5-hexanedione neurotoxicity by methyl ethyl ketone. (1985) (30)
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- A physiologically based pharmacokinetic model for lactational transfer of PCB 153 with or without PCB 126 in mice (2007) (29)
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- Dichloroacetate (DCA) dosimetry: interpreting DCA-induced liver cancer dose response and the potential for DCA to contribute to trichloroethylene-induced liver cancer. (1999) (28)
- Progestin receptor expression in the developing rat brain depends upon activation of estrogen receptor α and not estrogen receptor β (2006) (28)
- The distribution and metabolism of cyclotrimethylenetrinitramine (RDX) in the rat after subchronic administration. (1978) (28)
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- The use of biochemical and molecular parameters to estimate dose-response relationships at low levels of exposure. (1998) (25)
- Refined PBPK model of aggregate exposure to methyl tertiary-butyl ether. (2007) (25)
- Prediction of in vivo kinetic constants for metabolism of inhaled vapors from kinetic constants measured in vitro. (1981) (25)
- Lessons learned, challenges, and opportunities: the U.S. Endocrine Disruptor Screening Program. (2014) (25)
- PBPK modeling of complex hydrocarbon mixtures: gasoline. (2004) (25)
- Mechanistic modeling of rodent liver tumor promotion at low levels of exposure: an example related to dose-response relationships for 2,3,7,8-tetrachlorodibenzo-p-dioxin (1998) (24)
- Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity (2016) (23)
- Pharmacokinetic modeling of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and in rabbit brain following single dose administration. (1994) (23)
- PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human (2016) (23)
- Glutathione S-transferase-mediated mutagenicity of trihalomethanes in Salmonella typhimurium: contrasting results with bromodichloromethane off chloroform. (1997) (23)
- Effect of dose, time, and pretreatment on the biliary excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. (1993) (23)
- Combined exposure to 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone and microsytin-LR increases genotoxicity in Chinese hamster ovary cells through oxidative stress. (2013) (23)
- A model for pharmacokinetics and physiological feedback among hormones of the testicular-pituitary axis in adult male rats: a framework for evaluating effects of endocrine active compounds. (1998) (23)
- Dose-response modeling of etoposide-induced DNA damage response. (2014) (23)
- Recent advances in methodology and concepts for characterizing inhalation pharmacokinetic parameters in animals and man. (1982) (23)
- Stochastic Modeling of B Lymphocyte Terminal Differentiation and Its Suppression by Dioxin (2010) (23)
- An approach to mechanism-based cancer risk assessment for formaldehyde. (1993) (23)
- Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARγ expression (2019) (23)
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- Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts (2017) (22)
- Water pollutant fingerprinting tracks recent industrial transfer from coastal to inland China: A case study (2013) (22)
- Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays. (2018) (22)
- Application of a multi-route physiologically based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys. (2012) (22)
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- PBTK Modeling Demonstrates Contribution of Dermal and Inhalation Exposure Components to End-Exhaled Breath Concentrations of Naphthalene (2007) (22)
- Workshop overview: reassessment of the cancer risk of dichloromethane in humans. (2006) (22)
- Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1‐day and multi‐week exposures (2017) (21)
- Dose–response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop (2014) (21)
- Evaluation of biologically based dose-response modeling for developmental toxicity: a workshop report. (2000) (21)
- Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors. (1997) (21)
- PBPK modeling/Monte Carlo simulation of methylene chloride kinetic changes in mice in relation to age and acute, subchronic, and chronic inhalation exposure. (1996) (21)
- Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation. (2016) (21)
- The inhalation toxicity of sulfolane (tetrahydrothiophene-1,1-dioxide). (1977) (21)
- A dermatotoxicokinetic model of human exposures to jet fuel. (2006) (20)
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- An inhalation distribution model for the lactating mother and nursing child. (1988) (20)
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- Binary gene induction and protein expression in individual cells (2006) (19)
- Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine. (2006) (19)
- 3-chlorotyrosine and 3,5-dichlorotyrosine as biomarkers of respiratory tract exposure to chlorine gas. (2008) (19)
- Derivation of a drinking water equivalent level (DWEL) related to the maximum contaminant level goal for perfluorooctanoic acid (PFOA), a persistent water soluble compound. (2009) (19)
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- The acute toxicity of single, oral doses of 1,1-dichloroethylene in the fasted, male rat: effect of induction and inhibition of microsomal enzyme activities on mortality. (1978) (18)
- Progestin receptor expression in the developing rat brain depends upon activation of estrogen receptor alpha and not estrogen receptor beta. (2006) (18)
- Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment (2012) (18)
- Fluid Dynamic Modeling to Support the Development of Flow-Based Hepatocyte Culture Systems for Metabolism Studies (2016) (18)
- Cancer and non‐cancer risk assessment should be harmonized (1997) (18)
- Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction (2012) (18)
- Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5. (2016) (18)
- Induction of CYP1A1 in primary rat hepatocytes by 3,3',4,4',5-pentachlorobiphenyl: evidence for a switch circuit element. (2004) (18)
- Closed-Chamber Inhalation Pharmacokinetic Studies with Hexamethyldisiloxane in the Rat (2003) (17)
- Mutagenicity of trans-anethole, estragole, eugenol, and safrole in the Ames Salmonella typhimurium assay. (1982) (17)
- Development of a physiologically based pharmacokinetic model for 2,4-dichlorophenoxyacetic acid dosimetry in discrete areas of the rabbit brain. (1995) (17)
- Quantitative mechanistically based dose-response modeling with endocrine-active compounds. (1999) (17)
- Occupational exposure limits in the context of solvent mixtures, consumption of ethanol, and target tissue dose (2004) (17)
- Quantitative modeling in toxicology (2010) (17)
- Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver (2017) (16)
- Editor’s Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance (2017) (16)
- What do we Mean by Dose (1995) (16)
- Approaches for characterizing threshold dose-response relationships for DNA-damage pathways involved in carcinogenicity in vivo and micronuclei formation in vitro. (2016) (16)
- Building shared experience to advance practical application of pathway-based toxicology: liver toxicity mode-of-action. (2014) (16)
- Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods. (2020) (16)
- Derivation of an Inhalation Reference Concentration Based upon Olfactory Neuronal Loss in Male Rats following Subchronic Acetaldehyde Inhalation (2008) (16)
- Pharmacokinetic modeling approaches for describing the uptake, systemic distribution, and disposition of inhaled chemicals. (1995) (16)
- PB-PK derived metabolic constants, hepatotoxicity, and lethality of BrCCl3 in rats pretreated with chlordecone, phenobarbital, or mirex. (1991) (16)
- Based on an analysis of mode of action, styrene‐induced mouse lung tumors are not a human cancer concern (2018) (16)
- Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. (2003) (16)
- All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2013) (15)
- A comparison of the toxicology of triethylene glycol dinitrate and propylene glycol dinitrate. (1973) (15)
- Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop. (2019) (15)
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- Physiologically based clearance/extraction models for compounds metabolized in the nose: an example with methyl methacrylate. (2001) (14)
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- Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms (2021) (13)
- The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay. (2019) (13)
- Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tracts (2013) (13)
- Pharmacokinetic Interactions of Mixtures (1984) (13)
- PBPK Modeling: A Primer (2010) (13)
- A Risk Assessment Approach for Nursing Infants Exposed to Volatile Organics through the Mother's Occupational Inhalation Exposure (1989) (13)
- Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates. (2020) (13)
- Pharmacokinetic bias analysis of the epidemiological associations between serum polybrominated diphenyl ether (BDE-47) and timing of menarche. (2016) (13)
- Dose-response assessment strategies for endocrine-active compounds. (1997) (12)
- Physiologically Based Pharmacokinetic Modeling: A Tool for Understanding ADMET Properties and Extrapolating to Human (2013) (12)
- Introduction: A Historical Perspective of the Development and Applications of PBPK Models (2005) (12)
- Polychlorotrifluoroethylene (PCTFE) oligomer pharmacokinetics in Fischer 344 rats: development of a physiologically based model. (1992) (12)
- Developing tools for defining and establishing pathways of toxicity (2015) (12)
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- The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium (2016) (12)
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- Improving Risk Assessment: Research Opportunities in Dose Response Modeling to Improve Risk Assessment (2002) (11)
- A Model for Pharmacokinetics and Physiological Feedback among Hormones of the Testicular-Pituitary Axis in Adult Male Rats: A Framework for Evaluating Effects of Endocrine Active Compounds (1998) (11)
- Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use. (2017) (11)
- A pharmacokinetic model describing pulsatile uptake of orally-administered carbon tetrachloride. (1997) (11)
- Using gene expression profiling to evaluate cellular responses in mouse lungs exposed to V2O5 and a group of other mouse lung tumorigens and non-tumorigens. (2015) (11)
- U.S. Environmental Protection Agency's revised cancer guidelines for carcinogen risk assessment. (1998) (11)
- Deriving an explicit hepatic clearance equation accounting for plasma protein binding and hepatocellular uptake. (2013) (11)
- Probing the control elements of the CYP1A1 switching module in H4IIE hepatoma cells. (2005) (11)
- Risk science in the 21st century: a data-driven framework for incorporating new technologies into chemical safety assessment (2017) (10)
- Perfluoro-N-decanoic acid effects on enzymes of fatty acid metabolism. (1990) (10)
- A physiologically-based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin (1989) (10)
- Pollution trees: identifying similarities among complex pollutant mixtures in water and correlating them to mutagenicity. (2012) (10)
- Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part I: Program Implementation and Lessons Learned (2012) (10)
- Bioactivation and Toxicity of Acetaminophen in a Rat Hepatocyte Micropatterned Coculture System (2013) (10)
- COMPARING RESPIRATORY-TRACT AND HEPATIC EXPOSURE-DOSE RELATIONSHIPS FOR METABOLIZED INHALED VAPORS: A PHARMACOKINETIC ANALYSIS (2002) (10)
- Strain‐related differences in mouse lung gene expression over a two‐year period of inhalation exposure to styrene: Relevance to human risk assessment (2018) (9)
- Refinement of the oral exposure description in the cyclic siloxane PBPK model for rats and humans: Implications for exposure assessment. (2017) (9)
- A perspective on biologically-based approaches to dioxin risk assessment. (1991) (9)
- On the mechanism of the oxidation of human and rat hemoglobin by propylene glycol dinitrate. (1973) (9)
- Biologically based modeling in toxicology research. (1992) (9)
- Pitfalls and Related Improvements of In Vivo Gas Uptake Pharmacokinetic Experimental Systems (2005) (9)
- Enhancement of 1,1-dichloroethylene toxicity by pretreatment of fasted male rats with 2,3-epoxypropan-1-ol. (1977) (9)
- Improving toxicology testing protocols using computer simulations. (1989) (9)
- A toxicogenomic approach for the risk assessment of the food contaminant acetamide (2019) (9)
- Dose-incidence relationships derived from superposition of distributions of individual susceptibility on mechanism-based dose responses for biological effects. (2006) (9)
- An improved approximation to the exact solution of the two-stage clonal growth model of cancer. (1995) (9)
- Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation. (2008) (9)
- Under What Conditions Is Trichloroethylene Likely To Be a Carcinogen in Humans? (2001) (9)
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- A Multiple Dose-Route Physiological Pharmacokinetic Model for Volatile Chemicals Using ACSL/PC, (1986) (8)
- Assessing Kinetic Determinants for Metabolism and Oral Uptake of Octamethylcyclotetrasiloxane (D4) from Inhalation Chamber Studies (2008) (8)
- Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene (2019) (8)
- Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system. (2019) (8)
- A pharmacokinetic model of anaerobic in vitro carbon tetrachloride metabolism. (1996) (8)
- PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water (2016) (8)
- Toxicokinetic Principles in Relation to Percutaneous Absorption and Cutaneous Toxicity (1984) (8)
- The Toxicology of Perfluorodecanoic Acid in Rodents (1983) (8)
- Estimating constants for metabolism of atrazine in freshly isolated rat hepatocytes by kinetic modeling. (2007) (8)
- In utero exposure to chloroquine alters sexual development in the male fetal rat. (2009) (8)
- Calling on Science: Making “Alternatives” the New Gold Standard (2010) (8)
- Response to Comments by Caldwell et al. on Article “Applying Mode-of-Action and Pharmacokinetic Considerations in Contemporary Cancer Risk Assessments: An Example with Trichloroethylene” (2006) (8)
- Using quantitative modeling tools to assess pharmacokinetic bias in epidemiological studies showing associations between biomarkers and health outcomes at low exposures. (2021) (7)
- The genotoxic potential of mixed nitrosamines in drinking water involves oxidative stress and Nrf2 activation. (2021) (7)
- Development of 3D dynamic flow model of human liver and its application to prediction of metabolic clearance of 7-ethoxycoumarin. (2014) (7)
- Assessing children's exposure to manganese in drinking water using a PBPK model. (2019) (7)
- Assessing kinetic determinants for metabolism and oral uptake of octamethylcyclotetrasiloxane (D4) from inhalation chamber studies. (2008) (7)
- Some neurotoxic properties of triethylene glycol dinitrate: a comparison with decamethonium. (1976) (7)
- Liquid–air partition coefficients of 1,1‐difluoroethane (HFC152a), 1,1,1‐trifluoroethane (HFC143a), 1,1,1,2‐tetrafluoroethane (HFC134a), 1,1,1,2,2‐pentafluoroethane (HFC125) and 1,1,1,3,3‐pentafluoropropane (HFC245fa) (2010) (7)
- Application of transcriptomic data, visualization tools and bioinformatics resources for informing mode of action (2018) (7)
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- Mode of Action Studies for Assessing Carcinogenic Risks Posed by Inorganic Arsenic (1999) (6)
- A Kinetic Analysis of DNA-Deoxy Guanine Adducts in the Nasal Epithelium Produced by Inhaled Formaldehyde in Rats—Assessing Contributions to Adduct Production From Both Endogenous and Exogenous Sources of Formaldehyde (2020) (6)
- Biological and physiological factors involved in disposition of dioxin and related compounds (1992) (6)
- Development of a Mechanism-Based Dosimetry Model for 2,4,4-Trimethyl-2-pentanol-Induced α2u-Globulin Nephropathy in Male Fischer 344 Rats (1995) (6)
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- Predicting cytotoxicity of complex mixtures in high cancer incidence regions of the Huai River Basin based on GC-MS spectrum with partial least squares regression. (2015) (6)
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- 1988 Herbert E. Stokinger Lecture: Quantitative Risk Assessment and Occupational Carcinogens (1988) (5)
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- Application of the Risk Assessment Approaches in the USEPA Proposed Cancer Guidelines to Inorganic Arsenic (1999) (5)
- Food for Thought ... Can Case Study Approaches Speed Implementation of the NRC Report : “ Toxicity Testing in the 21 st Century : A Vision and a Strategy ? ” (2011) (5)
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- Estimating Minimally Effective Inducing Doses (EDOls) of TeDD in Livers of Rats and Humans Using Physiologically Based Pharmacokinetic Modeling (1997) (3)
- THE USE OF MEAN SURVIVAL TIME ANALYSIS TO DETERMINE COMPARATIVE TOXICITY OF FIRE ATMOSPHERES (1976) (3)
- The Use of Quantitative Histological and Molecular Data for Risk Assessment and Biologically Based Model Development (2002) (3)
- A Pharmacodynamic Model of Atrazine Effects on Estrous Cycle Characteristics in the Sprague-Dawley Rat (1998) (3)
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- Kinetic and Mechanistic Data Needs for a Human Phsiologically Based Pharmacokinetic (PBPK) Model for Acrylamide (2005) (3)
- Percutaneous Toxicokinetics of Hydrazine and H-70 in the Rabbit (1981) (3)
- Chapter 6:Using Transcriptomics to Evaluate Thresholds in Genotoxicity Dose–Response (2016) (3)
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- Physiologically‐based pharmacokinetic modeling suggests similar bioavailability of Mn from diet and drinking water (2018) (2)
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- Chapter 13:Modeling Manganese Kinetics for Human Health Risk Assessment (2014) (1)
- Mode of Action and Tissue Dosimetry Considerations in Interspecies Extrapolation (2007) (1)
- Reactive Vapors in the Nasal Cavity (2005) (1)
- A Systematic Approach to Evaluate Plausible Modes of Actions for Mouse Lung Tumors in Mice Exposed to 4-Methylimidozole. (2021) (1)
- Consideration of styrene transcriptomic data informs mouse lung Cyp2F2-mediated AOP. (2020) (1)
- Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse. (Reannouncement with new availability information). Final report (1991) (1)
- S-078: Use of Physiologically-based Pharmacokinetic Models to Evaluate Epidemiologic Associations that may be Due to Reverse Causality (2012) (1)
- Integration of paraquat pharmacokinetic data across species using PBPK modelling. (2021) (1)
- Biologically based risk assessment model for cyclophosphamide hematotoxicity in animal species: concluding comments. (2000) (1)
- Evaluation of Quantitative Models in Toxicology: Progress and Challenges (2010) (1)
- Liver bioreactor as an in vitro metabolism system for quantitative in vitro to in vivo extrapolation (2014) (1)
- Computer Simulation of Chemical Carcinogenesis (1989) (1)
- 104. A Program Developed by a High-Tech Consortium for Acquiring Chemical Toxicity Data for New and Unique Chemicals (2001) (1)
- SYMPOSIUM OVERVIEW Biologically Based, Quantitative Risk Assessment of Neurotoxicant s (1996) (1)
- Future directions in risk science (2017) (1)
- AN OVERVIEW OF THE OUTSTANDING ISSUES IN THE RISK ASSESSMENT OF METHYLENE CHLORIDE (1992) (1)
- Physiologically Based Kinetic Modeling of Inhalation (2014) (0)
- Physiologically based pharmacokinetic modeling of the pregnant rat: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. (Reannouncement with new availability information). Interim report, April 1986-December 1988 (1989) (0)
- Assessing Bioactivity-Exposure Profiles of Fruits and Vegetables in the BioMAP Profiling System (2019) (0)
- Erratum: “Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?” (2014) (0)
- Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics (2004) (0)
- RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days (2021) (0)
- P30—Development of rat gestation and lactation pBPK models for PFOA/PFOS (2012) (0)
- Effect of Nonadecafluorodecanoic Acid on Microsomal Stearoyl-CoA desaturase and Electron Transport Activities in Rat Liver (1983) (0)
- Making safety decisions based on changes in toxicity pathways: A case study (2012) (0)
- Pharmacokinetic Modeling of Manganese – An Essential Element (2010) (0)
- Occupational safety considerations with hydrazine (1992) (0)
- Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity (2022) (0)
- Mode of Action Studies Do Not Support Distant Site Carcinogenic Targets for Formaldehyde (2009) (0)
- Scientists in India Sensitized About Systems Biology Approach to Toxicity Testing : Hands-on Workshop on Computational Systems Biology and Dose-Response Modeling (2013) (0)
- Using Pharmacokinetic modeling to enhance Mn risk assessment (2013) (0)
- Use of Computational Modeling to Evaluate Hypotheses About the Molecular and Cellular Mechanisms of Bystander Effects (2006) (0)
- Predictive Models of Genome-wide Aryl Hydrocarbon Receptor DNA Binding Reveal Tissue Specific Binding Determinants (2022) (0)
- Two‐Stage Clonal Growth Modeling of Cancer (2010) (0)
- Modeling Liver and Kidney Cytotoxicity (2010) (0)
- Letters to the editor (2005) (0)
- Toxicity testing in the 21st century: progress in the past decade and future perspectives (2019) (0)
- Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity (2016) (0)
- Biologically based mathematical simulation of cytotoxicity and mutation accumulation (1987) (0)
- In vitro evaluation of dose-dependent chemically induced DNA damage and p53 pathway response (2011) (0)
- Short title: EA CFD-PBPK chronic risk assessment (2004) (0)
- A physiologically-based pharmacokinetic (PBPK) model describing the oral uptake of CCl4 from different dosing vehicles in fasted and fed rats (1995) (0)
- Response to the Letter to the Editor: “The Dose-Response Model for Dioxin” (1998) (0)
- Further Comments on the Bioavailability of [D.Sub.4]. (Correspondence) (2002) (0)
- Liver bioreactor and incorporation of metabolism and biokinetics into the integrated cell-based toxicity system (2016) (0)
- Computational Systems Biology Modeling of Dosimetry and Cellular Response Pathways (2008) (0)
- Chapter 24:The Role of Computational Systems Biology Models in Toxicity Testing in the 21st Century: an Example with Predictive Multi-Scale Models of the Liver (2011) (0)
- Application of the TT21C strategy to safety assessment using genetic toxicology as a case study (2014) (0)
- UNITED STATES AIR FORCE ARMSTRONG LABORATORY DCA Dosimetry: Interpreting DCA- Induced Liver Cancer Dose Response and the Potential for DCA to Contribute to TCE-lnduced Liver Cancer (1998) (0)
- Computer demonstration of physiological-toxicokinetic models: demonstrating a computer model that simulates the estradiol (E2)-primed LH surge during proestrus in the rat (2003) (0)
- Incorporation of rapid association/dissociation processes in tissues into the monkey and human physiologically based pharmacokinetic models for manganese (2022) (0)
- Time-course of perfluoro-n-decanoic acid (PFDA)-induced changes in [14C]-palmitare oxidation measured in vivo in male fischer-344 rats (1987) (0)
- In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI (2012) (0)
- Simulation modeling of PFAA exposure and pharmacokinetics (2009) (0)
- The Mutagenicity of Safrole in Salmonella typhimurium, Saccharomyces cerevisiae, and L5178Y Mouse Lymphoma Cells Using the Fluctuation Test. (1982) (0)
- Biologically Based Pharmacokinetics and Cancer Risk Assessment (1991) (0)
- Abeta systems pharmacology: An initial model for wild type mouse, monkey, and human (2011) (0)
- Toxicity of selected bioactivated compounds in primary rat hepatocytes cultured in micropatterned co-cultures (2014) (0)
- Assessing Modes of Action, Measures of Tissue Dose and Human Relevance of Rodent Toxicity Endpoints with Octamethylcyclotetrasiloxane (D4) (2022) (0)
- A Molecular Perspective on Exposure–Dose–Response (2010) (0)
- NAM-based Prediction of Point-of-contact Toxicity in the Lung: A Case Example With 1,3-dichloropropene. (2022) (0)
- DCA Dosimetry: Interpreting DCA- Induced Liver Cancer Dose Response and the Potential for DCA to Contribute to TCE-Induced Liver Cancer. (1998) (0)
- Biologically Based Models in Risk Assessment (1993) (0)
- Response to the Letter to the Editor: “The Dose‐Response Model for Dioxin” (1998) (0)
- Life beyond the air phase: adding tissue disposition to models of nasal airway transport (2006) (0)
- The Toxicity of Perfluoro-N-Decanoic Acid and 2,3,7,8- Tetrachlorodibenzo-P-Dioxin in L5178Y Mouse Lymphoma Cells (1983) (0)
- The effects of perfluorodecanoic acid on hepatic stearoyl-coenzyme A desaturase and mixed function oxidase activities in rats. (1988) (0)
- Streamlining metabolite identification and toxicity testing using alginate supported 3D culture of primary hepatocytes (2016) (0)
- Incorporation of a Recirculating Mobile Lipid Pool Description into the Cyclic Volatile Siloxane (cVMS) PBPK Model Captures Terminal Clearance of D4 after Repeated inhalation Exposure in F344 and SD Rats. (2022) (0)
- DOSE-RESPONSE APPROACHES REPORT OF A WORKSHOP ON DOSE-RESPONSE APPROACHES FOR NUCLEAR RECEPTOR-MEDIATED MODES OF ACTION (2010) (0)
- Modeling of Protein Induction and Dose‐Dependent Hepatic Sequestration (2010) (0)
- LETTER TO EDITOR Response to "Accurate Risk-Based Chemical Screening Relies on Robust Exposure Estimates" (2012) (0)
- Toxicogenomics for transcription factor-governed molecular pathways: moving on to roles beyond classification and prediction (2012) (0)
- Research Career Overview (2017) (0)
- Toxicity Studies of Formaldehyde Monomethylhydrazone (1983) (0)
- An overview of PFAA pharmacokinetics (2012) (0)
- Review of the three papers in the BELLE Newsletter (1998) (0)
- Advancing integrated approaches to animal-free chemical safety assessment using an Adverse Outcome Pathway framework (2014) (0)
- Percutaneous Absorption of Chemical Vapors (1985) (0)
- 00 00 o < A Comparison of the Toxicology of Triethylene Glycol Dinitraui and Propylene Glycol Dinitrate (2012) (0)
- Dose Response Modeling with Monoalkylphthalates: Assessing Cellular Targets for Mechanism-Based Risk Assessments (2007) (0)
- Updating the Biologically Based Dose Response Model for the Nasal Carcinogenicity of Inhaled Formaldehyde in the F344 Rat. (2023) (0)
- Response to “letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.” (UIHT-2020-0053) (2020) (0)
- A A GENERAL REFERENCE ON PHYSIOLOGICALLY-BASED PHARMACOKINETIC / PHARMACODYNAMIC ( PBPK / PD ) MODELING (2004) (0)
- Risk Assessment Approaches for Chlorine and Other Respiratory Tract Irritant Gases (2010) (0)
- Relationship of hepatotoxicity and lethality with metabolic constants of BrCCl3 in rats pretreated with chlordecone, phenobarbital and mirex☆ (1990) (0)
- Developing tools for defining and establishing pathways of toxicity (2015) (0)
- Physiologically based pharmacokinetics and methylene chloride cancer risk assessment considerations† (2020) (0)
- Adverse outcome pathway driven development of human cell-based assays sufficient for safety assessment of estrogenic chemicals (2016) (0)
- Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods (2022) (0)
- Occupational safety considerations with hydrazine fuels (1992) (0)
- TheUseofBiochemical andMolecular Parameters toEstimate DoseResponse Relationships atLowLevels ofExposure (1998) (0)
- Title Long Isoforms of NRF 1 Contribute to Arsenic-Induced Antioxidant Response in Human Keratinocytes (2010) (0)
- Electron transfer flux in redox network with Nrf2 regulation under hydrogen peroxide stress (2012) (0)
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What Are Melvin E. Andersen's Academic Contributions?
Melvin E. Andersen is most known for their academic work in the field of chemistry. They are also known for their academic work in the fields of
Melvin E. Andersen has made the following academic contributions:
