Mervyn Singer

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Mervyn Singer

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Philosophy

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Mervyn Singer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). (2016) (13437)
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017) (3647)
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016 (2017) (2976)
Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). (2016) (2599)
Hydrocortisone therapy for patients with septic shock. (2008) (1617)
Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). (2016) (1545)
Association between mitochondrial dysfunction and severity and outcome of septic shock (2002) (1316)
Trial of early, goal-directed resuscitation for septic shock. (2015) (1273)
Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. (2005) (1207)
Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial (2005) (942)
Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial (1997) (843)
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine (2008) (807)
Mechanisms of sepsis-induced cardiac dysfunction (2007) (619)
Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit (1999) (555)
Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. (2013) (553)
Biomarkers in sepsis (2013) (504)
Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation (2004) (487)
Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit: The Oxygen-ICU Randomized Clinical Trial. (2016) (485)
Intensive Care Medicine Experimental (2017) (443)
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. (2004) (442)
Mechanisms of sepsis-induced organ dysfunction (2007) (427)
The role of mitochondrial dysfunction in sepsis-induced multi-organ failure (2013) (405)
Clinical review: Update on hemodynamic monitoring - a consensus of 16 (2011) (340)
Survival in critical illness is associated with early activation of mitochondrial biogenesis. (2010) (338)
Early, Goal‐Directed Therapy for Septic Shock — A Patient‐Level Meta‐Analysis (2017) (337)
A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators (2015) (324)
Unexpected Deaths and Referrals to Intensive Care of Patients on General Wards – Are Some Cases Potentially Avoidable? (1999) (315)
Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study (2021) (313)
Tracheostomy in the COVID-19 era: global and multidisciplinary guidance (2020) (310)
Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery (2004) (301)
Linezolid resistance in clinical isolates of Staphylococcus aureus. (2003) (289)
Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit (2005) (280)
Randomised trial of safety and efficacy of immediate postoperative enteral feeding in patients undergoing gastrointestinal resection (1996) (272)
Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix (2011) (266)
Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting? (2009) (266)
Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017. (2020) (263)
Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis (2014) (263)
Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two centre study (2005) (258)
Continuous hemodynamic monitoring by esophageal Doppler. (1989) (257)
Terlipressin for norepinephrine-resistant septic shock (2002) (251)
Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression (2006) (250)
Mitochondrial dysfunction in sepsis (2003) (230)
The validity of trans-esophageal Doppler ultrasonography as a measure of cardiac output in critically ill adults (2004) (229)
Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis. (2016) (228)
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl (2015) (221)
Mitochondrial function in sepsis: Acute phase versus multiple organ failure (2007) (211)
Vasopressin: Mechanisms of action on the vasculature in health and in septic shock (2007) (198)
The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock (2009) (197)
In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent (2009) (196)
TUMOUR NECROSIS FACTOR IN BRONCHOPULMONARY SECRETIONS OF PATIENTS WITH ADULT RESPIRATORY DISTRESS SYNDROME (1989) (196)
Adrenal function in sepsis: The retrospective Corticus cohort study (2007) (188)
Inflammation and Endothelial Function: Direct Vascular Effects of Human C-Reactive Protein on Nitric Oxide Bioavailability (2005) (181)
The medical use of oxygen: a time for critical reappraisal (2013) (167)
COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study (2020) (166)
Hyperpyrexia and rhabdomyolysis after MDMA ("ecstasy") abuse (1992) (157)
Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections* (2015) (154)
Levosimendan pre-treatment improves outcomes in patients undergoing coronary artery bypass graft surgery. (2009) (154)
Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis (2012) (152)
Noninvasive optimization of left ventricular filling using esophageal Doppler (1991) (149)
Cardioprotection, attenuated systemic inflammation, and survival benefit of &bgr;1-adrenoceptor blockade in severe sepsis in rats* (2010) (130)
Pathophysiology of sepsis-induced cardiomyopathy (2021) (130)
Cellular energetic metabolism in sepsis: the need for a systems approach. (2008) (129)
Effects of alterations in left ventricular filling, contractility, and systemic vascular resistance on the ascending aortic blood velocity waveform of normal subjects (1991) (128)
Hemodynamic effects of manual hyperinflation in critically ill mechanically ventilated patients. (1994) (127)
Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis * (2007) (126)
Preconditioning effects of levosimendan in coronary artery bypass grafting--a pilot study. (2006) (124)
Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy (2016) (124)
Antibiotics for Sepsis-Finding the Equilibrium. (2018) (123)
Bench-to-bedside review: Potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure (2006) (122)
Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist (2015) (118)
The Pancreatitis Outcome Prediction (POP) Score: A new prognostic index for patients with severe acute pancreatitis* (2007) (118)
Survival of HIV-infected patients in the intensive care unit in the era of highly active antiretroviral therapy (2007) (118)
Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis. (1995) (117)
British HIV Association and British Infection Association guidelines for the treatment of opportunistic infection in HIV‐seropositive individuals 2011 (2011) (116)
Linezolid versus teicoplanin in the treatment of Gram-positive infections in the critically ill: a randomized, double-blind, multicentre study. (2004) (115)
Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum (2016) (115)
Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices (2009) (112)
Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial. (2015) (112)
The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: A randomized crossover study in critical care units in two hospitals* (2011) (110)
Improved survival for HIV infected patients with severe Pneumocystis jirovecii pneumonia is independent of highly active antiretroviral therapy (2006) (110)
Microvascular Effects of Heart Rate Control With Esmolol in Patients With Septic Shock: A Pilot Study* (2013) (109)
Metabolic phenotype of skeletal muscle in early critical illness (2018) (109)
Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study (2018) (108)
Catecholamine treatment for shock—equally good or bad? (2007) (108)
Angiotensin II Blockade Augments Renal Cortical Microvascular pO2 Indicating a Novel, Potentially Renoprotective Action (2003) (107)
H1N1 pneumonitis treated with intravenous zanamivir (2009) (107)
The Effect of Sepsis on the Erythrocyte (2017) (106)
36th International Symposium on Intensive Care and Emergency Medicine (2016) (103)
Alteration of the sublingual microvascular glycocalyx in critically ill patients. (2013) (102)
The role of mitochondria in sepsis-induced cardiomyopathy. (2019) (100)
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads (2020) (100)
Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective (2012) (100)
TREM‐1 promotes survival during septic shock in mice (2007) (99)
Expression of two molecular forms of the complement decay-accelerating factor in the eye and lacrimal gland. (1990) (98)
The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching. (2013) (98)
The heart in sepsis: from basic mechanisms to clinical management. (2013) (98)
Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages. (2005) (97)
Protocolised Management In Sepsis (ProMISe): a multicentre randomised controlled trial of the clinical effectiveness and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock. (2015) (96)
Role of KATP channels in sepsis. (2006) (93)
Multicenter comparison of cortisol as measured by different methods in samples of patients with septic shock (2009) (92)
Mitochondrial dysfunction in patients with severe sepsis: an EPR interrogation of individual respiratory chain components. (2006) (90)
Current use of vasopressors in septic shock (2019) (90)
Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study (2016) (87)
Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study) (2018) (85)
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis (2018) (85)
International registry on the use of the CytoSorb® adsorber in ICU patients (2019) (83)
Antibiotic use and impact on outcome from bacteraemic critical illness: the BActeraemia Study in Intensive Care (BASIC). (2010) (82)
Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication (2010) (81)
Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients (2012) (81)
Antibiotics for Sepsis: Does Each Hour Really Count, or Is It Incestuous Amplification? (2017) (80)
Hyperglycemia in Critical Illness: A Review (2009) (79)
Inflammation biomarkers and delirium in critically ill patients (2014) (79)
Is the inflammasome a potential therapeutic target in renal disease? (2014) (78)
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (2018) (77)
Critical care: advances and future perspectives (2010) (77)
The oxygen trail: tissue oxygenation. (1999) (77)
Renal Effects of Levosimendan: A Consensus Report (2013) (74)
Pharmacokinetic studies of linezolid and teicoplanin in the critically ill. (2005) (72)
Tissue oxygen and hemodynamics in renal medulla, cortex, and corticomedullary junction during hemorrhage-reperfusion. (2006) (72)
An evaluation of the clinical and cost-effectiveness of pulmonary artery catheters in patient management in intensive care: a systematic review and a randomised controlled trial. (2006) (71)
The stress response and critical illness: A review* (2012) (71)
Cellular dysfunction in sepsis. (2008) (70)
Variability in management of early severe sepsis (2010) (69)
Esophageal Doppler Monitoring of Aortic Blood Flow: Beat‐by-Beat Cardiac Output Monitoring (1993) (68)
Use of non-invasive ventilation for patients with COVID-19: a cause for concern? (2020) (68)
Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies. (2012) (68)
Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle (2007) (65)
The role of ADAMTS‐13 in the coagulopathy of sepsis (2018) (64)
Treating Critical Illness: The Importance of First Doing No Harm (2005) (63)
Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. (2013) (63)
Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis (2017) (63)
Tissue oxygen monitoring in rodent models of shock. (2007) (62)
Mitochondrial Dysfunction in Sepsis. (1999) (61)
Optimal intensive care outcome prediction over time using machine learning (2018) (59)
Understanding the benefits and harms of oxygen therapy (2015) (58)
The intensive care medicine research agenda on septic shock (2017) (57)
Human Septic Myopathy: Induction of Cyclooxygenase, Heme Oxygenase and Activation of the Ubiquitin Proteolytic Pathway (2004) (57)
Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis (2015) (57)
Prediction of postoperative cardiac surgical morbidity and organ failure within 4 hours of intensive care unit admission using esophageal Doppler ultrasonography. (1999) (57)
Sepsis hysteria: excess hype and unrealistic expectations (2019) (56)
Clinical outcomes and risk factors for severe COVID‐19 in patients with haematological disorders receiving chemo‐ or immunotherapy (2020) (55)
Esophageal Doppler: Noninvasive Cardiac Output Monitor (2003) (53)
Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. (2010) (53)
Continuous venovenous haemofiltration using polyacrylonitrile filters does not activate contact system and intrinsic coagulation pathways (1997) (53)
Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials (2021) (53)
Time course of organ failure in patients with septic shock treated with hydrocortisone: results of the Corticus study (2011) (53)
Dangers of hyperoxia (2021) (52)
Redefining critical illness (2022) (52)
Commentary. Balancing sedation and analgesia in the critically ill. (2001) (52)
Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning (2013) (52)
The impact of hospitalization on dental plaque accumulation: an observational study. (2012) (52)
Oesophageal Doppler (2009) (51)
Cellular processes in sepsis. (2008) (51)
Microcirculatory dysfunction and resuscitation: why, when, and how. (2015) (50)
The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study (2019) (50)
Delay to admission to critical care and mortality among deteriorating ward patients in UK hospitals: a multicentre, prospective, observational cohort study (2015) (49)
Impact of time to antibiotic therapy on clinical outcome in patients with bacterial infections in the emergency department: implications for antimicrobial stewardship. (2020) (48)
Patients with end-stage renal disease admitted to the intensive care unit: systematic review. (2013) (48)
Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review (2022) (48)
Critical illness and flat batteries (2017) (48)
Microvascular and Interstitial Oxygen Tension in the Renal Cortex and Medulla Studied in A 4-H Rat Model of LPS-Induced Endotoxemia (2011) (48)
Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study (2017) (48)
The new sepsis consensus definitions (Sepsis-3): the good, the not-so-bad, and the actually-quite-pretty (2016) (47)
Continuous measurement of cardiac output during aortic cross-clamping by the oesophageal Doppler monitor ODM 1. (1995) (47)
Is MOF an outcome parameter or a transient, adaptive state in critical illness? (2009) (47)
Activation of the tissue factor pathway occurs during continuous venovenous hemofiltration. (1999) (47)
Oxford Handbook of Critical Care (1997) (46)
ABC of intensive care (2011) (46)
Do we need a new definition of sepsis? (2015) (46)
Case mix, outcome, and activity for admissions to UK critical care units with severe acute pancreatitis: a secondary analysis of the ICNARC Case Mix Programme Database (2007) (45)
Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study (2018) (45)
Computer keyboards and the spread of MRSA. (2006) (45)
Haemodynamic evidence for cardiac stress during transurethral prostatectomy. (1992) (45)
The metabolic phenotype of rodent sepsis: cause for concern? (2013) (44)
Tissue oxygen tension monitoring of organ perfusion: rationale, methodologies, and literature review. (2015) (44)
Temporal changes in tissue cardiorespiratory function during faecal peritonitis (2011) (44)
Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France (2019) (44)
Monitoring tissue perfusion, oxygenation, and metabolism in critically ill patients. (2013) (44)
[Pyr1]Apelin-13(1–12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13 (2017) (43)
The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage (2009) (43)
Impact on mortality of prompt admission to critical care for deteriorating ward patients: an instrumental variable analysis using critical care bed strain (2018) (43)
Renal Tubular Cell Mitochondrial Dysfunction Occurs Despite Preserved Renal Oxygen Delivery in Experimental Septic Acute Kidney Injury (2018) (40)
Survival of HIV-infected patients admitted to the intensive care unit in the era of highly active antiretroviral therapy (2011) (40)
Thirty years of critical care medicine (2010) (40)
Critical Care Health Informatics Collaborative (CCHIC): Data, tools and methods for reproducible research: A multi-centre UK intensive care database (2018) (40)
Variability of treatment duration for bacteraemia in the critically ill: a multinational survey. (2003) (40)
Multicenter, Randomized, Placebo-Controlled Phase III Study of Pyridoxalated Hemoglobin Polyoxyethylene in Distributive Shock (PHOENIX)* (2015) (39)
An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial (2014) (39)
Cardiorespiratory and tissue oxygen dose response to rat endotoxemia. (1996) (39)
Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (2018) (39)
Metabolic monitoring in the intensive care unit: a comparison of the Medgraphics Ultima, Deltatrac II, and Douglas bag collection methods. (2015) (39)
Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models (2017) (38)
Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis* (2007) (38)
The pore‐forming subunit of the KATP channel is an important molecular target for LPS‐induced vascular hyporeactivity in vitro (2005) (38)
Changes in CRH and ACTH Synthesis during Experimental and Human Septic Shock (2011) (38)
Heparin clearance during continuous veno-venous haemofiltration (2005) (37)
Stressing the obvious? An allostatic look at critical illness (2010) (37)
Potential metabolic consequences of statins in sepsis* (2011) (36)
Temporal variation in endotoxin‐induced vascular hyporeactivity in a rat mesenteric artery organ culture model (2001) (35)
Large variation in MRSA policies, procedures and prevalence in English intensive care units: a questionnaire analysis (2002) (35)
The cost of intensive care: A comparison on one unit between 1988 and 1991 (1994) (35)
Managing malaria in the intensive care unit (2014) (34)
Intensive care and emergency medicine: progress over the past 25 years. (2006) (34)
Treatment of pulmonary hypertension in the general adult intensive care unit: a role for oral sildenafil? (2005) (34)
Dimethylarginine Dimethylaminohydrolase 2 Regulates Nitric Oxide Synthesis and Hemodynamics and Determines Outcome in Polymicrobial Sepsis (2015) (34)
Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide (2005) (33)
In vitro susceptibility of Gram-positive pathogens to linezolid and teicoplanin and effect on outcome in critically ill patients. (2006) (32)
Prospective audit of bacteraemia management in a university hospital ICU using a general strategy of short-course monotherapy. (2004) (31)
Part III: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Fluid Resuscitation and Antimicrobial Therapy Endpoints. (2019) (31)
Importance of the environment for patient acquisition of methicillin-resistant Staphylococcus aureus in the intensive care unit: A baseline study (2007) (31)
Talactoferrin in Severe Sepsis: Results From the Phase II/III Oral tAlactoferrin in Severe sepsIS Trial (2015) (30)
Invasive hemodynamic monitoring in the United Kingdom. Enough or too little? (1989) (30)
Inflammation - From Molecular and Cellular Mechanisms to the Clinic: From Molecular and Cellular Mechanisms to the Clinic (2017) (30)
Bench-to-bedside review: The role of C1-esterase inhibitor in sepsis and other critical illnesses (2011) (30)
Judging quality of current septic shock definitions and criteria (2015) (30)
Post hoc insights from PAC-Man—The U.K. pulmonary artery catheter trial* (2008) (29)
Metabolic dysfunction in lymphocytes promotes postoperative morbidity. (2015) (29)
An integrated approach to assessing nitroso-redox balance in systemic inflammation. (2011) (29)
Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness* (2016) (29)
The evolutionary role of nutrition and metabolic support in critical illness. (2010) (29)
Critical Care Algorithms (1992) (29)
Clinical equipoise remains for issues of adrenocorticotropic hormone administration, cortisol testing, and therapeutic use of hydrocortisone. (2003) (28)
Keeping the Circuit Open: Lessons from the Lab (2002) (28)
Microvascular and macrovascular flow are uncoupled in early polymicrobial sepsis. (2012) (28)
Low-molecular-weight polyethylene glycol improves survival in experimental sepsis* (2010) (28)
Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock. (2014) (28)
Purinergic signaling in inflammatory renal disease (2013) (28)
Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study (2016) (28)
Haemodynamic evidence for per-operative cardiac stress during transurethral prostatectomy. Preliminary communication. (1991) (27)
Intravenous crocetinate prolongs survival in a rat model of lethal hypoxemia (2000) (27)
Changes in dental plaque following hospitalisation in a critical care unit: an observational study (2013) (27)
Optimising organ perfusion in the high-risk surgical and critical care patient: a narrative review. (2019) (27)
Multi-Organ Dysfunction in the Critically Ill: Effects on Different Organs (2000) (27)
Clinical review: A systematic review of corticosteroid use in infections (2005) (27)
Hyperoxia toxicity in septic shock patients according to the Sepsis-3 criteria: a post hoc analysis of the HYPER2S trial (2018) (27)
Hypothermia protects brain mitochondrial function from hypoxemia in a murine model of sepsis (2015) (27)
Cardiovascular performance and core temperature during transurethral prostatectomy. (1994) (26)
Tissue oxygen tension monitoring: will it fill the void? (2011) (26)
Expert Panel: The use of the pulmonary artery catheter (1991) (26)
Management of the transurethral prostate resection syndrome: time for reappraisal? (1990) (26)
The optimal time for measuring the cardiorespiratory effects of positive end-expiratory pressure. (1993) (26)
Bacteraemia incidence, causative organisms and resistance patterns, antibiotic strategies and outcomes in a single university hospital ICU: continuing improvement between 2000 and 2013. (2015) (26)
Equilibrating SSC guidelines with individualized care (2021) (26)
Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis. (2015) (25)
Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model. (2019) (25)
Peripheral Neural Detection of Danger–Associated and Pathogen–Associated Molecular Patterns (2013) (25)
The Surviving Sepsis guidelines: evidence-based ... or evidence-biased? (2006) (25)
The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study. (2017) (24)
Optimisation of positive and expiratory pressure for maximal delivery of oxygen to tissues using oesophageal Doppler ultrasonography. (1989) (24)
Effects of short-term hyperoxia on erythropoietin levels and microcirculation in critically Ill patients: a prospective observational pilot study (2017) (24)
Management of the dialysis patient in general intensive care. (2012) (23)
Metabolic failure. (2005) (23)
Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges (2012) (23)
Bacterial infections in critically ill patients with SARS-2-COVID-19 infection: results of a prospective observational multicenter study (2021) (23)
Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats (2013) (23)
The FTc is not an accurate marker of left ventricular preload (2006) (23)
Current use of inotropes in circulatory shock (2021) (23)
Inhibition of mitochondrial respiration during early stage sepsis. (2003) (22)
Organ failure in the ICU: cellular alterations. (2011) (22)
Discriminating between CPAP success and failure in COVID-19 patients with severe respiratory failure (2020) (22)
Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia (2019) (22)
SARS-CoV-2 pandemic: clinical picture of COVID-19 and implications for research (2020) (22)
Pitfalls of pulmonary artery catheterization highlighted by Doppler ultrasound. (1989) (22)
Multiple Organ Dysfunction (2019) (21)
Free radical in blood: a measure of haemoglobin autoxidation in vivo?† (1997) (21)
Vasopressin Synthesis by the Magnocellular Neurons is Different in the Supraoptic Nucleus and in the Paraventricular Nucleus in Human and Experimental Septic Shock (2010) (21)
Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial (2019) (21)
Inhaled nitric oxide minimally improves oxygenation in COVID-19 related acute respiratory distress syndrome (2020) (21)
Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor (2020) (21)
Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research (2021) (21)
Sequential Analysis of a Panel of Biomarkers and Pathologic Findings in a Resuscitated Rat Model of Sepsis and Recovery (2017) (21)
Clinical review: Thinking outside the box - an iconoclastic view of current practice (2011) (21)
Nitrosyl heme production compared in endotoxemic and hemorrhagic shock. (2005) (20)
Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery (2007) (20)
Cardiorespiratory, tissue oxygen and hepatic NADH responses to graded hypoxia (1998) (20)
Effect of Extracorporeal Blood Purification on Mortality in Sepsis: A Meta-Analysis and Trial Sequential Analysis (2020) (20)
Short‐term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin‐mediated nitrite reduction (2014) (20)
Endothelial dysfunction in critically ill patients: the effect of haemofiltration (1998) (20)
Strategies to modulate cellular energetic metabolism during sepsis. (2007) (19)
Ghrelin, appetite and critical illness (2012) (19)
Relationship between norepinephrine dose, tachycardia and outcome in septic shock: A multicentre evaluation. (2020) (19)
Puerperal sepsis. (2013) (19)
In vivo validation of a miniaturized electrochemical oxygen sensor for measuring intestinal oxygen tension (2019) (19)
Nimodipine Reduces Dysfunction and Demyelination in Models of Multiple Sclerosis (2020) (19)
Arginine vasopressin vs. terlipressin in the treatment of shock states. (2008) (18)
Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways? (2018) (18)
Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A (2008) (18)
Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand (2017) (18)
Hemodynamic changes during sickle cell crisis. (1989) (18)
Teicoplanin resistance in methicillin-resistant Staphylococcus aureus in an intensive care unit. (2003) (18)
Sepsis: personalization v protocolization? (2019) (17)
Immunomodulators in COVID-19: Two Sides to Every Coin (2020) (17)
A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification (2019) (17)
Effect of dexamethasone in patients with ARDS and COVID-19 – prospective, multi-centre, open-label, parallel-group, randomised controlled trial (REMED trial): A structured summary of a study protocol for a randomised controlled trial (2021) (17)
Inhaled nitric oxide produces minimal improvement in oxygenation in COVID-19 related ARDS (2020) (16)
Sex-Mediated Response to the Beta-Blocker Landiolol in Sepsis: An Experimental, Randomized Study (2018) (16)
Plasma Exchange for COVID-19 Thrombo-Inflammatory Disease (2020) (16)
Oesophageal Doppler monitoring: should it be routine for high-risk surgical patients? (2011) (16)
Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis?* (2017) (15)
Multi-Organ Dysfunction in the Critically Ill: Epidemiology, Pathophysiology and Management (2000) (15)
Clinical Predictors of Survival and Functional Outcome of Stroke Patients Admitted to Critical Care* (2018) (15)
Management of multiple organ failure: guidelines but no hard-and-fast rules. (1998) (15)
Detailed Characterization of a Long-Term Rodent Model of Critical Illness and Recovery (2015) (15)
Decatecholaminisation during sepsis (2016) (15)
Cardiac output in 1998 (1998) (15)
qSOFA, Cue Confusion (2018) (15)
VARIABLE EFFECTS OF INHIBITING iNOS AND CLOSING THE VASCULAR ATP-SENSITIVE POTASSIUM CHANNEL (VIA ITS PORE-FORMING AND SULFONYLUREA RECEPTOR SUBUNITS) IN ENDOTOXIC SHOCK (2009) (15)
Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression (2020) (15)
Management of fluid balance: a European perspective (2012) (15)
Do critical care patients hibernate? Theoretical support for less is more (2019) (14)
Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter? (2019) (14)
Pharmacological optimization of tissue perfusion. (2009) (14)
Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle. (2019) (14)
DNA Nanodevices with Selective Immune Cell Interaction and Function. (2021) (14)
P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis (2018) (14)
Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target? (2014) (13)
Glucocorticoids in sepsis: dissecting facts from fiction (2011) (13)
Landiolol in patients with septic shock resident in an intensive care unit (LANDI-SEP): study protocol for a randomized controlled trial (2018) (13)
The key advance in the treatment of sepsis in the last 10 years ... doing less (2006) (13)
In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue (2015) (13)
BK Large Conductance Ca2+-Activated K+ Channel-Deficient Mice are not Resistant to Hypotension and Display Reduced Survival Benefit Following Polymicrobial Sepsis (2011) (13)
Intermittent positive pressure ventilation. (1992) (13)
Lipid metabolic signatures deviate in sepsis survivors compared to non-survivors (2020) (13)
Tumour necrosis factor in bronchopulmonary secretion of patients with adult respiratory distress syndrome (1989) (12)
Essentials of an intensive respiratory care unit. Report of the Subcommittee and Committee on Emphysema American College of Chest Physicians. (1971) (12)
Effect of Antibiotic Discontinuation Strategies on Mortality and Infectious Complications in Critically Ill Septic Patients: A Meta-Analysis and Trial Sequential Analysis* (2020) (12)
The Many Roles of Cholesterol in Sepsis: A Review. (2021) (12)
Convalescent plasma for COVID-19: a meta-analysis, trial sequential analysis, and meta-regression (2021) (12)
Transient changes in affect and blood pressure. (1962) (12)
ODM/CardioQ esophageal Doppler technology. (2003) (12)
Haemophagocytic lymphohistiocytosis in adult critical care (2020) (12)
Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock (2018) (12)
Infection in the critically ill—questions we should be asking (2011) (12)
Bladder epithelial oxygen tension — a new means of monitoring regional perfusion? Preliminary study in a model of exsanguination/fluid repletion (1996) (11)
Short-course monotherapy strategy for treating bacteremia in the critically ill. (2006) (11)
Oesophageal Doppler monitoring: a not‐so‐NICE editorial (2012) (10)
Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity (2022) (10)
Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine (2016) (10)
The new definitions of SEPSIS and SEPTIC SHOCK: What do they give us? An answer. (2017) (10)
What Faces Reveal: A Novel Method to Identify Patients at Risk of Deterioration Using Facial Expressions* (2018) (10)
Experience using high‐dose glucose‐insulin‐potassium (GIK) in critically ill patients (2017) (10)
Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures (2022) (10)
Heart rate elevations during early sepsis predict death in fluid-resuscitated rats with fecal peritonitis (2018) (9)
Fixed minimum fluid volume for resuscitation: Con (2017) (9)
Comparison of stroke volume measurement between non-invasive bioreactance and esophageal Doppler in patients undergoing major abdominal–pelvic surgery (2017) (9)
Balancing Sedation and Analgesia in the Critically I11 (2001) (9)
Immunotherapy in the management of sepsis. (1995) (9)
The UCL Ventura CPAP device for COVID-19 (2020) (9)
Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis (2012) (9)
Definitions for Sepsis and Septic Shock--Reply. (2016) (8)
Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice (2018) (8)
Sepsis - the broken code How accurately is sepsis being diagnosed? (2020) (8)
Pathophysiology of sepsis (2021) (8)
Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis. (2017) (8)
Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke (2020) (8)
Component reductions in oxygen delivery generate variable haemodynamic and stress hormone responses. (2014) (8)
Tissue Oxygenation in Sepsis (1999) (8)
Sepsis - thoughtful management for the non-expert. (2018) (8)
Plasma exchange for COVID‐19 thrombo‐inflammatory disease (2020) (7)
Esophageal Doppler monitoring (2005) (7)
Spreading the knowledge on the epidemiology of sepsis. (2017) (7)
Analysis of breath using SIFT-MS: A comparison of the breath composition of healthy volunteers and s (2005) (7)
Statin use and mortality in the bacteremic critically ill patient. (2006) (7)
Effects of hydrocortisone on posttraumatic stress disorder after septic shock: results from the CORTICUS Berlin Study Group (2008) (7)
Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions (2021) (7)
Comprar Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery | Abraham, Edward | 9783540301585 | Springer (2007) (7)
The Pharmacology and Therapeutic Utility of Sodium Hydroselenide (2021) (7)
Selective mitochondrial antioxidant MitoTEMPO reduces renal dysfunction and systemic inflammation in experimental sepsis. (2021) (7)
Personalizing Sepsis Care. (2018) (7)
Proceedings of Réanimation 2019, the French Intensive Care Society International Congress (2019) (6)
The oxygen cost of rehabilitation interventions in mechanically ventilated patients: an observational study. (2019) (6)
Reflections on Critical Care’s Past, Present, and Future (2021) (6)
Effect of linezolid and teicoplanin on skin staphylococci. (2007) (6)
Impact of ghrelin on body composition and muscle function in a long-term rodent model of critical illness (2017) (6)
Characterization of Brain–Heart Interactions in a Rodent Model of Sepsis (2016) (6)
Continuous Measurement of Cardiac Output During Aortic Cross-Clamping by the Oesophageal Doppler Monitor ODM 1 (1996) (6)
Sepsis in severe COVID-19 is rarely septic shock: a retrospective single-centre cohort study (2021) (6)
The effect of norepinephrine and dobutamine on bladder epithelial oxygen tension. (1995) (6)
Management of a mixed overdose of calcium channel blockers, β-blockers and statins (2014) (6)
Seven unconfirmed ideas to improve future ICU practice (2017) (5)
Protection of cerebral microcirculation, mitochondrial function, and electrocortical activity by small‐volume resuscitation with terlipressin in a rat model of haemorrhagic shock (2017) (5)
Effects of atrial natriuretic peptide on systemic haemodynamics and cardiac function in normal man. (1989) (5)
Consensus Statement for Pharmacological Management of Coronavirus Disease 2019 (COVID-19): A Pragmatic Approach (2020) (5)
Intelligently learning from data (2019) (5)
Give oxygen, get a blood pressure... but don't overdo it. (2005) (5)
RADICAL study: rapid diagnosis of suspected bloodstream infections from direct blood testing using PCR/ESI-MS (2014) (5)
Sinus Arrest and Severe Peripheral Vasodilation Following Cardiopulmonary Bypass in a Patient Taking Nicorandil (1997) (5)
Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT (2018) (5)
Defining Septic Shock--Reply. (2016) (5)
Recovery from organ failure is associated with improved mitochondrial function in septic patients (2003) (5)
Challenging management dogma where evidence is non-existent, weak or outdated (2022) (5)
Deconstructing Hyperlactatemia in Sepsis Using Central Venous Oxygen Saturation and Base Deficit (2019) (5)
Infections due to antibiotic-resistant gram-positive cocci (1993) (5)
Descriptors of Sepsis Using the Sepsis-3 Criteria: A Cohort Study in Critical Care Units Within the U.K. National Institute for Health Research Critical Care Health Informatics Collaborative* (2021) (5)
Managing critically ill patients with a pulmonary artery catheter. (2006) (5)
The Pancreatitis Outcome Prediction (POP) score: How about hematocrit and leukopenia? (2007) (5)
Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method (2021) (5)
The β1-Adrenergic Receptor Contributes to Sepsis-Induced Immunosuppression Through Modulation of Regulatory T-Cell Inhibitory Function* (2022) (5)
Screening for MRSA and GISA in the intensive care unit. (2006) (5)
Our favorite unproven ideas for future critical care (2013) (5)
Human monoclonal IgG anticardiolipin antibodies induce nitric oxide synthase expression. (2006) (5)
Chemistry, pharmacology, and cellular uptake mechanisms of thiometallate sulfide donors (2020) (5)
Advancing critical care: time to kiss the right frog (2013) (5)
Hemodynamic Monitoring Using Aortic Doppler (1990) (4)
Powering up failed organs. (2007) (4)
Intensive Care and Emergency Medicine (1984) (4)
Acute kidney injury (2012) (4)
Steroids in ARDS: more light is being shed (2020) (4)
What's in a beat? (2003) (4)
Another nail in the hammer's coffin? (2011) (4)
Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (2018) (4)
How to use biomarkers of infection or sepsis at the bedside: guide to clinicians (2023) (4)
Effect of corticosteroids on mortality and clinical cure in community-acquired pneumonia: A systematic review, meta-analysis, and meta-regression of randomized control trials. (2022) (4)
Potential economic consequences of a cardioprotective agent for patients with myocardial infarction: modelling study (2015) (4)
Bladder epithelial oxygen tension as a marker of organ perfusion (1995) (4)
Short-acting β-blocker administration in patients with septic shock--reply. (2014) (4)
Steroids in patients with septic shock. (2009) (4)
Executable network of SARS-CoV-2-host interaction predicts drug combination treatments (2021) (4)
The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update? (2023) (4)
Mitochondria — key roles in sepsis (2013) (4)
ESICM LIVES 2016: part three (2016) (4)
Antibiotic prophylaxis to prevent surgical site infections: should it be prolonged or just perioperative and efficacious? (2010) (4)
ESICM LIVES 2016: part three (2016) (4)
Influence of IL-6 levels on patient survival in COVID-19 (2021) (4)
A new dawn for critical care research (2013) (4)
Microcirculation vs. Mitochondria—What to Target? (2020) (4)
Critical care algorithm. Positive end-expiratory pressure. (1990) (4)
The role of K ATP channels in sepsis (2006) (4)
ESICM LIVES 2016: part three : Milan, Italy. 1-5 October 2016. (2016) (3)
Association between sepsis at ICU admission and mortality in patients with ICU-acquired pneumonia: An infectious second-hit model. (2020) (3)
Acute Medicine Algorithms (1995) (3)
Exploring alternative routes for oxygen administration (2016) (3)
Correction to: Impact on mortality of prompt admission to critical care for deteriorating ward patients: an instrumental variable analysis using critical care bed strain (2018) (3)
Female hormones prevent sepsis-induced cardiac dysfunction: an experimental randomized study (2021) (3)
In vivo and in vitro differences in responses to catecholamines and vasopressin in rat models of LPS (2002) (3)
COVID-19 and non-COVID ARDS patients demonstrate a distinct response to low dose steroids- A retrospective observational study (2020) (3)
Uncontrolled interventions during pandemics: a missed learning opportunity? (2020) (3)
Understanding the benefits and harms of oxygen therapy: response to comments by Akca (2015) (3)
Thinking forward: promising but unproven ideas for future intensive care (2019) (3)
Fundamentals of oxygen delivery. (2007) (3)
Cardiac stress during transurethral prostatectomy: Authors' reply (1992) (3)
LIVER CIRRHOSIS AND INTENSIVE CARE, UNHAPPY BEDFELLOWS? AN ANALYSIS OF ADMISSIONS TO ICU WITH CIRRHOSIS OVER A 12 YEAR PERIOD FROM THE INTENSIVE CARE NATIONAL AUDIT & RESEARCH CENTRE (ICNARC) DATABASE (2009) (3)
Italy versus the United Kingdom: differing styles for treating bacteremia in the critically ill patient, but who's right? (2008) (3)
Cellular and molecular mechanisms of IMMunE dysfunction and Recovery from SEpsis-related critical illness in adults: An observational cohort study (IMMERSE) protocol paper (2020) (3)
The FTc is not an accurate marker of left ventricular preload. Reply to the comment by Chemla and Nitenberg (2006) (3)
The Cell, the Mitochondrion, Oxygen and Sepsis (1996) (3)
Mitochondrial dysfunction in human septic shock (1999) (3)
Intramural feeding: a complication of percutaneous endoscopic gastrostomy feeding. (2005) (3)
Beta-blockers in sepsis: time to reconsider current constraints? (2017) (3)
System interactions. (2007) (3)
Sepsis: the importance of an accurate final diagnosis. (2020) (3)
Oxford Handbook of Critical Care 3rd (2009) (3)
Inotropic Support in the Treatment of Septic Myocardial Dysfunction: Pathophysiological Implications Supporting the Use of Levosimendan (2014) (3)
Biomarkers for sepsis – past, present and future (2019) (3)
Oxygen and Oxidative Stress (2018) (3)
Severe bloodstream infections from the community: risk factors and outcomes. (2004) (3)
The Pharmacokinetic Profiles of Linezolid and Teicoplanin in the critically ill. (2002) (3)
Timely selection of adequate antifungal therapy for candidemia in the critically ill: don't let the yeast rise! (2008) (3)
Learning for the next pandemic: the Wuhan experience of managing critically ill people (2021) (3)
Reductions in tyrosine levels are associated with thyroid hormone and catecholamine disturbances in sepsis (2015) (2)
Effect of Dexamethasone In Patients With ARDS And COVID-19 (REMED Trial) – Study Protocol For A Prospective, Multi-Centre, Open-Label, Parallel-Group, Randomized Controlled Trial (2021) (2)
Critical care algorithms. Management of continuous haemo(dia)filtration. (1990) (2)
Genomic Characteristics and Clinical Impact of the Emergent SARS-CoV-2 B.1.1.7 Lineage in North Central London, November to December 2020 (2021) (2)
Risk factors associated with bloodstream infections among critically ill patients with COVID-19 (2021) (2)
High oxygen level in traumatic brain injury patients. Never ending story? (2022) (2)
Clinical severity and local inflammatory responses in animal models of sepsis (2010) (2)
Effect of dexamethasone in patients with ARDS and COVID-19 (REMED trial)—study protocol for a prospective, multi-centre, open-label, parallel-group, randomized controlled trial (2022) (2)
Nitrosopersulfide (SSNO-) targets soluble guanylyl cyclase and induces vasodilation in vivo (2015) (2)
Beta-blockade in experimental fluid-resuscitated sepsis: acute haemodynamic effects of esmolol differ in predicted survivors and non-survivors (2015) (2)
Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial (2021) (2)
Cellular energetic metabolism in sepsis (2008) (2)
Only KATP channel inhibitors binding to the pore-forming subunit reverse LPS-induced hyporeactivity (2002) (2)
Dysfunction of the Bioenergetic Pathway (2007) (2)
DELAY TO ADMISSION TO CRITICAL CARE AND MORTALITY AMONG DETERIORATING WARD PATIENTS IN 49 UK HOSPITALS - RESULTS FROM (SPOT)LIGHT: A MULTI-SITE, PROSPECTIVE, OBSERVATIONAL COHORT STUDY (2014) (2)
0036. Confocal imaging of impaired mitochondrial function in the cerebral cortex of rats during haemorrhagic shock in vivo (2014) (2)
Beta-blockers in sepsis (2019) (2)
Tissue Oxygen Tension Monitoring of Organ Perfusion: Rationale, Methodologies, and Literature Review (2016) (2)
Critical care data processing tools (2017) (2)
Surviving Sepsis Guidelines - A Bundle to Adopt? (2005) (2)
Early-onset candidemia: an increasing problem? (2009) (2)
Oxygenation of the critically ill in selected intensive care units in the UK: are we usual? (2020) (2)
The anion study: effect of different crystalloid solutions on acid base balance, physiology, and survival in a rodent model of acute isovolaemic haemodilution (2018) (2)
Mortality and clinical cure rates for pneumonia: A systematic review, meta-analysis, and trial sequential analysis of randomized control trials comparing bactericidal and bacteriostatic antibiotic treatments (2022) (2)
Efficacy of Doxycycline for Mild-to-moderate Community-acquired Pneumonia in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials. (2022) (2)
Severe sepsis: international and specialty variations in initial management (2008) (2)
The appropriateness of intensive respiratory care (1973) (2)
ESICM LIVES 2016: part one (2016) (2)
Reactive Oxygen Species in Clinical Practice (2000) (2)
Hypoxia-reoxygenation injury: impact on survival and outcome (1999) (2)
Sex differences in immunological responses to COVID-19: a cross-sectional analysis of a single-centre cohort (2021) (2)
Cortical and subcortical grey matter morphometry for neuroprognostication after cardiac arrest (2016) (2)
Hazard Ratios and Hazardous Carbapenemase-Producing Enterobacteriaceae. (2015) (2)
What Is Sepsis (2018) (2)
ESICM LIVES 2016: part two (2016) (2)
Low cost devices to help in COVID-19 (2021) (2)
Acute haemodynamic effects of dobutamine in experimental sepsis-induced myocardial depression (2015) (2)
Use of the oesophageal Doppler to facilitate resuscitation (2009) (2)
Composition of the Sepsis Definitions Task Force--Reply. (2016) (1)
Molecular mechanisms autonomic dysfunction and impaired cardiac contractility in critical illness (2016) (1)
Strategy focused on clinical parameters of microcirculation to resuscitate patients in septic shock: Do not forget any tools. (2019) (1)
Deconstructing Hyperlactatemia in Sepsis Using ScvO2 and Base Deficit. (2019) (1)
The Effect of Age on the Cardiovascular Response to Stress (1997) (1)
Reply to Tasker and to Lellouche and L’Her (2020) (1)
Butyrate Supplementation Exacerbates Myocardial and Immune Cell Mitochondrial Dysfunction in a Rat Model of Faecal Peritonitis (2022) (1)
An epistemological dilemma: is ertapenem adequate to treat severe infections in critically ill patients? (2011) (1)
The future of acute and emergency care (2021) (1)
Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS– A single centre retrospective analysis (2021) (1)
MEASURING CARDIAC OUTPUT (1988) (1)
Bronchogenic Cyst in Infants-Clinical and Histopathological Features (2022) (1)
Intensive Care Foundation Research Free Paper Presentations (2015) (1)
SKELETAL MUSCLE MITOCHONDRIAL DYSFUNCTION AFTER SHORT-TERM SEPTIC SHOCK (2015) (1)
PLASMA UBIQUINONE LEVELS ARE UNAFFECETED BY SIMVASTATIN IN ACUTE LUNG INJURY (2012) (1)
Source Isolation in ICU Does Not Reduce Spread of MRSA: A Prospective Two-Centre Study (2004) (1)
RENAL MACROPHAGE INFILTRATION IN A RAT MODEL OF SEPSIS AND RECOVERY (2013) (1)
Beneficial ex vivo immunomodulatory and clinical effects of clarithromycin in COVID-19 (2022) (1)
International Critical Care-From an Indulgence of the Best-Funded Healthcare Systems to a Core Need for the Provision of Equitable Care. (2021) (1)
Caring for Sepsis Patients: An Update. (2018) (1)
Continuous Noninvasive Aortic Blood Flow Monitoring (1996) (1)
Lessons and risks of medical device deployment in a global pandemic (2021) (1)
Immediate enteral feeding after gastrointestinal resection (1996) (1)
Admissions with airway emergencies in the ICU at a tertiary referral centre (2015) (1)
Clotting of Continuous Haemofiltration Circuits in Critically Ill Patients may be Related to low Levels of Anti-Thrombin III Rather than Heparin Clearance (1993) (1)
Mitochondrial inhibition is associated with the severity of human septic shock (2001) (1)
Corticosteroids for septic shock - Reply (2008) (1)
Favourable outcome for haematopoietic transplant recipients requiring intensive therapy unit admission: a 10-year single-centre experience (2009) (1)
Cardiovascular effects of dexmedotomidine for ITU sedation: UK results of a multi-centre study (St George's, University College, St Thomas's and Bristol Royal Infirmary Hospitals) (2000) (1)
A direct comparison between iNOS and KATP inhibition in an in vivo model of rat sepsis (2002) (1)
LPS induces inos in all layers of rat mesenteric artery in both in vitro and in vivo models (2003) (1)
Nitrosopersulfide (SSNO-) targets soluble guanylyl cyclase and induces vasodilation in vivo (2015) (1)
CHANGES IN SKELETAL MUSCLE NADH REDOX STATE, TISSUE OXYGENATION AND MICROVASCULAR BLOOD FLOW DURING GRADED HAEMORRHAGE (2012) (1)
Difficult diagnosis in the ICU: making the right call but beware uncertainty and bias (2023) (1)
ABC of Intensive Care Ed. 2 (2011) (1)
Critical care algorithms. Pulmonary artery and central venous catheter monitoring. (1990) (1)
MITOCHONDRIAL BIOGENESIS RESPONSE IS ASSOCIATED WITH POSITIVE OUTCOME IN CRITICALLY ILL PATIENTS (2009) (1)
Source isolation in intensive care units does not reduce spread of MRSA beyond that achieved by universal precautions: a prospective two-centre study (2003) (1)
Outcomes for patients with COVID‐19: known knowns, known unknowns, and unknown unknowns (2020) (1)
Severe Covid-19 disease: sepsis but rarely septic shock (2021) (1)
Esmolol reduces arterial elastance in septic shock (2017) (1)
Allostasis and sedation practices in intensive care evaluation: an observational pilot study (2018) (1)
Oxidative stress and critical illness. (2007) (1)
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients (2022) (1)
Intracellularly Released Cholesterol from Polymer-Based Delivery Systems Alters Cellular Responses to Pneumolysin and Promotes Cell Survival (2021) (1)
The use of glypressin in norepinephrine-resistant septic shock (2001) (1)
Power cut: Mitochondrial dysfunction in sepsis (2005) (1)
The use of oxygen in acute exacerbations of chronic obstructive pulmonary disease: a prospective audit of pre-hospital and hospital emergency management. (2003) (1)
Obituary - David Bennett (2012) (1)
DAYS SPENT AT HOME AND MORTALITY AFTER CRITICAL ILLNESS: A CLUSTER ANALYSIS USING NATIONWIDE DATA. (2022) (1)
Levosimendan in Sepsis. (2017) (1)
Creating complex protocells and prototissues using simple DNA building blocks (2023) (1)
Defining Potential Therapeutic Targets in Coronavirus Disease 2019: A Cross-Sectional Analysis of a Single-Center Cohort (2021) (1)
The challenge of pharmacological thromboprophylaxis in ICU patients: anti-FXa activity does not constitute the simple solution. Author's reply (2022) (1)
Decrease in VO2 in renal tubules from septic rats relates to clinical severity and nitric oxide (2002) (1)
Comprar Oxford Textbook Of Critical Care 2nd Ed. | Andrew Webb | 9780199600830 | OXFORD (2016) (1)
P2X(7) RECEPTOR AND HAEMORRHAGE-REPERFUSION. INDUCED ACUTE TUBULAR INJURY (2013) (0)
hemorrhage-reperfusion cortex, and corticomedullary junction during Tissue oxygen and hemodynamics in renal medulla, (2016) (0)
Terlipressin for haemodynamic support in septic patients: a double-edged sword? (2002) (0)
Chapter 32 Trauma and burns (2009) (0)
NULL MICE FOR THE CALCIUM ACTIVATED POTASSIUM CHANNEL ARE NOT RESISTANT TO HYPOTENSION AND SURVIVAL IS NOT IMPROVED COMPARED TO THEIR WILD TYPE LITTER MATES IN A FLUID RESUSCITATED MODEL OF FECAL PERITONITIS (2009) (0)
Airway and Ventilation Management (2021) (0)
Sepsis-induced acute kidney injury (2010) (0)
Chapter 23 Cardiovascular disorders (2009) (0)
Corticosteroids in adult respiratory distress syndrome – an inconvenient truth? (2021) (0)
Gram-positive bacteria secrete RNA aptamers to activate human STING for IL-1β release (2021) (0)
Clarithromycin as an immunomodulator in sepsis: still a (IN)CLASS act (2022) (0)
Additional file 3: of Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study (2016) (0)
Does transfer to intensive care units reduce mortality ? A comparison of an instrumental variables design to risk adjustment (2019) (0)
Brussels 2004 (2004) (0)
The Importance of Shifting Sepsis Quality Measures From Processes to Outcomes. (2023) (0)
Defining Potential Therapeutic Targets in COVID-19: A Cross-Sectional Analysis of a Single Centre Cohort (2021) (0)
0592. Metabolic acidosis induced by haemorrhage and hydrochloric acid generates different cardiorespiratory responses (2014) (0)
Chapter 37 Transport of the critically ill (2009) (0)
Multiple organ failure: Assessment & Therapeutic strategy (1999) (0)
Favourable outcome for allogeneic haematopoietic transplant recipients requiring intensive therapy unit admission with improved survival following reduced intensity conditioning (2009) (0)
The effect of exogenous ACTH on the serum cortisol / cortisone ratio in patients with septic shock (2006) (0)
F1000Prime recommendation of Analysis of overall level of evidence behind Infectious Diseases Society of America practice guidelines. (2011) (0)
Mitochondrial Function (2019) (0)
Glycolysis in Sepsis and other Stress Conditions (2003) (0)
Tracheostomy in critically ill patients with SARS 2 COVID-19 infection: a prospective observational multi-center study of short- and long-term outcomes (2022) (0)
Variation in antibiotic prescribing and influence of microbiologist for the treatment of bacteraemia (2002) (0)
Critical Care Minimum Data Set criteria (2015) (0)
Chapter 16 Renal drugs (2009) (0)
Could we treat Bacteraemia In The Critically Ill with a Short-Course Monotherapy Strategy: Results of a 6 Month Prospective Audit (2003) (0)
Anaesthetist or intensivist: continued debate. (2004) (0)
DOBUTAMINE STRESS ECHOCARDIOGRAPHY UNMASKS MYOCARDIAL DYSFUNCTION IN EARLY RODENT POLYMICROBIAL SEPSIS (2010) (0)
Chapter 13 Fluids (2009) (0)
Combining pathogen and host metagenomics for a better sepsis diagnostic (2022) (0)
Chapter 4 Renal therapy techniques (2009) (0)
0035. Mitochondrial uncoupling contributes to fever in sepsis (2014) (0)
Chapter 19 Haematological drugs (2009) (0)
From “bad infection” to organ failure (2020) (0)
“L'histoire se répète”, one size does not fit all. Author’s reply (2021) (0)
Short patient information sheet (2015) (0)
Wide variation in prevalence of bacteraemia: Preliminary results of a multinational survey(basic-2) (2003) (0)
Central venous catheter-related bacteraemia: Epidemiology, severity of illness and therapy (2001) (0)
Chapter 36 Obstetric emergencies (2009) (0)
SEPSIS DECREASES STROKE VOLUME YET INCREASES EX VIVO CARDIOMYOCYTE OXYGEN CONSUMPTION (2012) (0)
THE OXYGEN COST OF REHABILITATION IN ICU (2014) (0)
C URRENT OPINION Management of fluid balance: a European perspective (2012) (0)
Do Temporal Changes in Facial Expressions Help Identify Patients at Risk of Deterioration in Hospital Wards? A Post Hoc Analysis of the Visual Early Warning Score Study (2020) (0)
Respiratory Fluoroquinolone Monotherapy Versus Β-Lactam Plus Macrolide Combination Therapy for Hospitalised Adults with Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials (2022) (0)
The pre-symptomatic detection of early extreme response to an infection (sepsis) (2020) (0)
Faculty Opinions recommendation of Quorum sensing-dependent virulence during Pseudomonas aeruginosa colonisation and pneumonia in mechanically ventilated patients. (2010) (0)
THE FEASIBILITY OF MEASURING OXYGEN CONSUMPTION DURING REHABILITATION OF MECHANICALLY VENTILATED PATIENTS (2012) (0)
DOES THE TIMING OF INSTRUMENTATION UNDER ANAESTHESIA IMPACT UPON MORTALITY AND ORGAN FUNCTION IN A RODENT MODEL OF FECAL PERITONITIS (2011) (0)
Haemodynamic Changes Occuring during Sickle Cell Crisis (1989) (0)
Incidence of bacteraemia, severity of illness and outcome: a 6-month prospective audit (2001) (0)
Chapter 15 Cardiovascular drugs (2009) (0)
Faculty Opinions recommendation of Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients. (2009) (0)
Critical Care 3 Critical care: advances and future perspectives (2010) (0)
5 year experience of intensive care for critically ill patients following chemotherapy or bone marrow transplantation: Who should go to ICU? (2001) (0)
Acute/Chronic respiratory failure (1992) (0)
A Salutary Tale (2011) (0)
Unmet Medical Needs in Life‐Threatening Infections – Caring for the Critically Ill (2015) (0)
Tissue and plasma putrescine levels in non-survivors of sepsis in a fluid-resuscitated rat model of faecal peritonitis (2015) (0)
Chapter 14 Respiratory drugs (2009) (0)
Non-specialist therapeutic strategies in acute respiratory distress syndrome: a meta-analysis. (2021) (0)
Chapter 30 Poisoning (2009) (0)
Predictive risk factors for colonization and infection of central venous catheters (2001) (0)
David Bennett 1938–2012 (2012) (0)
SUBSTANTIAL DIFFERENCES IN TRIGGERING EVENTS AND FUNCTIONAL CONSEQUENCES BETWEEN MODELS OF ENDOTOXEMIA- AND SEPSIS-ASSOCIATED LIVER DYSFUNCTION (2011) (0)
Citations Professor David Bennett (2004) (0)
Chapter 21 Resuscitation (2009) (0)
Coping with Hypoxia (1999) (0)
LOW IMMUNOGLOBULIN I; LEVELS AT ADMISSION REDUCES THE ODDS FOR 28 DAY MORTALITY COMPARED TO NORMAL LEVELS (2012) (0)
Why aren't we practising homogenized medicine? (2007) (0)
Chapter 12 Miscellaneous monitoring (2009) (0)
Molecular and cellular mecahnisms in endotoxic shock: are potassium channels a novel therapeutic target (2000) (0)
The utility of CRP with the use of dexamethasone and Tocilizumab in critically ill patients with COVID-19 (2022) (0)
Additional file 2: of Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study (2016) (0)
Chapter 5 Gastrointestinal therapy techniques (2009) (0)
INORGANIC THIOMETALLATES AS A NEW CLASS OF SULFIDE-DONORS: CHEMISTRY, PHARMACOLOGY AND IMPACT ON ISCHEMIA/REPERFUSION INJURY (2017) (0)
High oxygen flow rates with the UCL Ventura CPAP device - Authors' reply. (2021) (0)
THE ANION STUDY: EFFECTS OF LARGE VOLUME RESUSCITATION ON ACID-BASE BALANCE, PHYSIOLOGY AND SURVIVAL (2013) (0)
P143 Using big data to investigate physiology: retention of co2 does not impact the oxygen-haemoglobin dissociation curve of critically ill adults (2017) (0)
0033. Hypothermia protects brain mitochondrial function from hypoxia in sepsis (2014) (0)
Faculty Opinions recommendation of Implementation of guidelines for management of possible multidrug-resistant pneumonia in intensive care: an observational, multicentre cohort study. (2011) (0)
NITRITE REDUCTASE ACTIVITY DURING SEPSIS (2013) (0)
Correction to: Dysregulated expression of the b2-adrenergic receptor insepsis (2021) (0)
Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review. (2022) (0)
Chapter 11 Laboratory monitoring (2009) (0)
Survey of the management of acute renal failure in the critically ill in England and Wales. (2004) (0)
Effects of MGC-0109, a slow-release sulphide donor, on myocardial ischaemia/reperfusion injury (2015) (0)
Comprar Oxford Handbook of Critical Care 3rd | Andrew Webb | 9780199235339 | Oxford University Press (2009) (0)
Management of critically ill patients with a pulmonary artery catheter did not reduce all cause mortality (2006) (0)
Less Haste, More Speed, More Science: Lessons to be Learned from COVID-19 Studies (2022) (0)
Stroke volume versus cardiac output as a marker for predicting postoperative morbidity (1998) (0)
Effects of statins on mitochondrial respiration and outcome during experimental sepsis (2012) (0)
Preface to the previous editions (2009) (0)
Feasibility of Noninvasive Positive Pressure Ventilation in the Treatment of Oxygen-Dependent COVID-19 Patients in Peru (2021) (0)
A plea for balanced reporting (2010) (0)
Chapter 8 Respiratory monitoring (2009) (0)
Chapter 3 Cardiovascular therapy techniques (2009) (0)
Comparison of renal replacement therapy and renal recovery before and during the COVID-19 pandemic. A single centre observational study. (2021) (0)
CHANGES IN EXERCISE CAPACITY AND MUSCLE FUNCTION IN A RECOVERY MODEL Of SEPSIS (2013) (0)
Critical Illness Is a (Mal)-Adaptive, Metabolic Response to Systemic Inflammation (2016) (0)
Chapter 22 Respiratory disorders (2009) (0)
Could we treat bacteremia in the critically ill with a short strategy? Results of a 6 month prospective audit. (2004) (0)
Chapter 33 Physical disorders (2009) (0)
Long-term mortality and quality of life after trauma: an ancillary study from the prospective multicenter trial FROG-ICU (2019) (0)
TETRATHIOMOLYBDATE, A SLOW RELEASE SULPHIDE DONOR, IMPROVES SURVIVAL IN A RAT MODEL OF HAEMORRHAGE/REPERFUSION INJURY (2012) (0)
Drugs in the critical illness – Vasoconstrictors (1999) (0)
Preface to this edition (2009) (0)
Selective mitochondrial antioxidant MitoTempo reduces renal dysfunction and systemic interleukin-1beta without impairing macrophage oxidative burst in experimental sepsis (2021) (0)
PROTECTING THE MITOCHONDRIA ‐ WHEN? HOW?: 454 (2004) (0)
FREE IMMUNOGLOBULIN LIGHT CHAIN CONCENTRATIONS, RATIOS ANT) OUTCOMES IN CRITICALLY ILL ADULTS WITH SEPSIS (2014) (0)
Cholesterol and its association with muscle weakness in critical illness (2021) (0)
Response to ‘Impact of immunosuppression on mortality in critically ill COVID‐19 patients’ (2020) (0)
Variable effects of inhibiting inducible nitric oxide synthase and closing the vascular ATP-sensitive potassium (KATP) channel (via its pore-forming and sulfonylurea receptor subunits) in endotoxic shock (2009) (0)
Differing strategies for antibiotic prescribing for bacteraemia in the critically ill patient (2003) (0)
Chapter 28 Haematological disorders (2009) (0)
Isolation of patients with MRSA infection (2005) (0)
Effect of Heart Rate ControlWith Esmolol on Hemodynamic and Clinical Outcomes in PatientsWith Septic Shock A Randomized Clinical Trial (2013) (0)
0082. Early circulating lipid and cytokine profiles prognosticate in a rat model of faecal peritonitis (2014) (0)
Author and Subject Index Proceedings (2002) (0)
SYMPATHETIC TONE AND VASCULAR KATP CHANNEL ACTIVITY (2009) (0)
Improving survival from HIV associated Pneumocystis jirovecii pneumonia admitted to the intensive care unit (2005) (0)
Inflammation, Hormones, and Metabolism (2017) (0)
0738. Mortality is associated with early tachycardia and cardiac troponin release in a fluid-resuscitated rat model of sepsis (2014) (0)
Bacteraemia & LRTI treatment with linezolid in the critically ill: a randomized double-blind (2002) (0)
Do critically ill patients with haematological malignancy survive intensive care and beyond (2002) (0)
Learning for the next pandemic: when high level evidence is not readily available… (2021) (0)
Improving Organ Function (2006) (0)
Trials on oxygen targets in the critically ill patients: do they change our knowledge and practice? (2023) (0)
Activation-associated death of memory b cells in peripheral circulation in adults with sepsis (2015) (0)
Treatment of bacteraemia and LRTI with linezolid in the critically ill patient: a randomized double-blind comparison against teicoplanin. (2002) (0)
The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction. (2023) (0)
Modulation of LTCC Pathways by a Melusin Mimetic Increases Ventricular Contractility During LPS-Induced Cardiomyopathy (2022) (0)
Do temporal changes in facial expressions help identify patients at risk of deterioration in hospital wards? A post-hoc analysis of the VIEWS study (2020) (0)
Enhanced expression of vascular K-ATP channels in an in vitro model of sepsis (2008) (0)
Early cardiac dysfunction in severe sepsis limits fluid loading and predicts long-term outcome (2007) (0)
Chpater 27 Neurological disorders (2009) (0)
Chapter 10 Neurological monitoring (2009) (0)
Major differences exist in bacteraemia management (2001) (0)
NEURO-IMMUNOMODULATION OF HUMAN CD14+CD16+NEUTROPHILS IN SEPSIS (2010) (0)
Sepsis results in early cholesterol and steroidogenesis pathway alterations (2015) (0)
INCIDENCE, DISPOSITION AND OUTCOME OF DETERIORATING WARD PATIENTS REFERRED TO CRITICAL CARE IN 49 UK HOSPITALS-RESULTS FROM (SPOT)LIGHT: A MULI-SITE, PROSPECTIVE, OBSERVATIONAL COHORT STUDY (2014) (0)
Chapter 1 Critical care organisation and management (2009) (0)
iNOS expression and peroxynitrite production is associated with mitochondrial dysfunction in skeleta (2002) (0)
Sex-mediated response to landiolol, a ß1 selectif adrenergic blocker, in myocardial dysfunction during sepsis (2018) (0)
Reduction in mitochondrial biogenesis balanced by a shift away from fat metabolism in critically ill patients (2014) (0)
Faculty Opinions recommendation of Mini-bronchoalveolar lavage quantitative polymerase chain reaction for diagnosis of methicillin-resistant Staphylococcus aureus pneumonia. (2010) (0)
Communications to the EditorCardiorespiratory Effects of Positive End-Expiratory Pressure (1994) (0)
BACTERAEMIA STUDY IN ICU PHASE 2: EPIDEMIOLOGICAL AND MICROBIOLOGICAL RESULTS.: 39 (2005) (0)
DESCRIPTIVE EVALUATION OF CIRRHOTIC PATIENTS ADMITTED TO A GENERAL INTENSIVE CARE UNIT WITH ACUTE DECOMPENSATION OF CHRONIC LIVER DISEASE (2009) (0)
0078. Establishing a detailed short-term rat model of partial ischaemia/reperfusion injury (2014) (0)
SIMULTANEOUS ASSESSMENT OF RENAL MICROVASCULAR AND INTERSTITIAL OXYGEN TENSION DURING ENDOTOXAEMIA (2009) (0)
A novel DDAH-1 inhibitor improved sepsis-induced impairment in vasoreactivity to noradrenaline in a rat endotoxaemia model (2011) (0)
Chapter 35 Oncological critical care (2009) (0)
Survival Of HIV-Infected Patients Admitted To The Intensive Care Unit In The Era Of Haart (2010) (0)
Association Between Hypocholesterolemia and Mortality in Critically Ill Patients With Sepsis: A Systematic Review and Meta-Analysis (2023) (0)
IMMUNOGTOBUTLN G CONCENTRATIONS AND OUTCOMES CRITICALLY ILL ADULTS WITH SEPSIS (2014) (0)
Recognition and Treatment of Severe COVID-19 in Pregnancy: Lessons from a Cohort of 69 Infected Women and an Evidence-Based Guideline (2020) (0)
SIGNIFICANCE OF MITOCHONDRIAL DYSFUNCTION IN THE CRITICALLY ILL: 227 (2004) (0)
Source, type, and resistance patterns of nosocomial bacteraemia in a teaching hospital ICU: a 6-month prospective audit (2001) (0)
O23 Poor hand hygiene can negate the efficacy of an enhanced cleaning regimen (2009) (0)
So you want to be ... a critical care physician. (2010) (0)
Back to Basics…and Translating to Success-A Call to Arms. (2020) (0)
Oxford Handbook of Critical Care THIRD EDITION (2009) (0)
Optimising organ perfusion: the high-risk surgical patient and the sick ICU patient (2019) (0)
The Capsule Of Streptococcus Pneumoniae Is Pro-Inflammatory (2014) (0)
Chapter 24 Renal disorders (2009) (0)
Endocrine emergencies: diagnosis and intensive care. (1971) (0)
Non-Invasive Determination of Changes in Left Ventricular Filling, Inotropy and Systemic Vascular Resistance (1988) (0)
Basic (bacteraemia study in ICU) phase 2: Preliminary results of a prospective multicentre audit (2003) (0)
Medication errors: comparison of electronic and hand-written prescribing in the ICU (2004) (0)
Chapter 17 Gastrointestinal drugs (2009) (0)
Modulation of hepatic uncoupling protein 2 expression by leptin in polymicrobial sepsis in vivo. (2004) (0)
A Radical Approach To Diagnosing Infection (2015) (0)
NO-cGMP pathway has a major role in endotoxin-induced vascular hyporeactivity in rat mesenteric artery (2001) (0)
Opposing effects of the kinin B1 and B2 receptors in LPS‐induced hypotension. (2008) (0)
Chapter 29 Metabolic disorders (2009) (0)
The Kidney in Sepsis (2002) (0)
A novel dimethylarginine dimethylaminohydrolase (DDAH-1) inhibitor improves survival, hemodynamics and organ function in rodent sepsis (2014) (0)
Dataset for "An implantable microfabricated sensor for real-time measurement of tissue oxygenation" (2019) (0)
S6/1 Cellular energetic metabolism in sepsis (2008) (0)
Intravenous oxygen administration in a rat model of hypoxia (2015) (0)
Nitric oxide independent inhibition of the mitochondrial respiratory chain in HepG2 cells (2002) (0)
Endothelial dysfunction in intensive care patients: The effect of haemofiltration (1998) (0)
Protective effects of low dose stabilized haemoglobin solution in experimental global ischaemia-reperfusion injury (2015) (0)
Sex-mediated response to beta-blockers in sepsis : an experimental , randomized study (2018) (0)
Subcutaneous reserpine dehydrates Wistar rats and increases nitric oxide production in septic rats (2013) (0)
Different calcium mobilisation pathways underlie the changes in vascular reactivity to norepinephrine and vasopressin in septic shock (2008) (0)
LOW DOSE L-NMMA IMPROVES SURVIVAL IN A LONG-TERM RAT MODEL OF SEPTIC SHOCK (2009) (0)
A novel DDAH-1 inhibitor improved cardiovascular function in a short-term anesthetized rat model of sepsis (2011) (0)
UNCOUPLING PROTEIN-3 MEDIATES THE LOSS OF MITOCHONDRIAL MEMBRANE POTENTIAL IN SEVERE SEPSIS (2009) (0)
0099. Nitrite reductase activity during sepsis (2014) (0)
Abnormal mitochondrial respiratory chain activity and glutathione levels in human septic shock (1999) (0)
Vascular hyporeactivity in human colonic marginal artery is induced by a cytokine-endotoxin combination (2001) (0)
The influence of age and respiratory failure on the outcome of complicated acute renal failure (1993) (0)
12 Intensive care (2011) (0)
Falls in Cardiac Output with Chest Hyperinflation are Related to Tidal Volumes Rather than Peak Inspiratory Pressures Generated (1993) (0)
WITHDRAWN: Strategy focused on clinical parameters of microcirculation to resuscitate patients in septic shock: do not forget any tools. (2019) (0)
S86 The Inflammatory Response To Streptococcus Pneumoniae Is Exaggerated By The Polysaccharide Capsule (2014) (0)
Case Report Bronchogenic Cyst in Infants-Clinical and Histopathological Features (2022) (0)
Patients With End-Stage Renal Disease Admitted to the Intensive Care Unit: Systematic Review (2014) (0)
S82 Survival of HIV-infected patients admitted to the intensive care unit (2010) (0)
THE IMPACT OF CRITICAL CARE ON ORAL HEALTH. AN OBSERVATIONAL STUDY (2012) (0)
Posters_Monday_12 October 2009 (2009) (0)
Chapter 18 Neurological drugs (2009) (0)
Differences in Fat Metabolism Between Predicted Survivors And Non-Survivors of Faecal Peritonitis (2015) (0)
S136 Lung protective mechanical ventilation for acute respiratory failure is not being implemented in uk clinical practice (2017) (0)
Choice of resuscitation fluids (2016) (0)
Chapter 25 Gastrointestinal disorders (2009) (0)
Non-conventional ventilatory modes (1992) (0)
Thinking outside the box: Introduction. (2010) (0)
EFFECTS OF HYPEROXIA, HYPOXAMENIA HAEMORRHAGE ON BLADDER TISSUE OXYGEN TENSION IN PIGS (2012) (0)
Chapter 2 Respiratory therapy techniques (2009) (0)
Free Papers (2011) (0)
The 2018 Intensive Care Society Cauldron debates: “The Next Critical Care Game Changer is …” (2019) (0)
Insertion of a pulmonary artery flotation catheter: how to do it. (1997) (0)
Pretreatment with a Nitric Oxide Inhibitor Reduces Infarct size in both the in vivo and the in vitro Rabbit Heart (1993) (0)
bioenergetics (but not UCP3) in a rodent model of sepsis Skeletal muscle dysfunction is associated with derangements in mitochondrial (2015) (0)
FVII is activated during continuous veno-venous haemofiltration (CVVH) (1997) (0)
biomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trial (2023) (0)
Iconographies supplémentaires de l'article : Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies (2012) (0)
The effects of lipopolysaccharide on levcromakalim- and forskolin-induced relaxation in endothelium-denuded rat aorta (2002) (0)
0889. Mitochondrial dysfunction contributes to sepsis-induces acute kidney injury (2014) (0)
TO TRANSUSE OR NOT TRANSFUSE? THAT IS THE QUESTION: 474 (2004) (0)
Characterization of Brain–Heart Interactions in a Rodent Model of Sepsis (2016) (0)
0030. Effect of exercise training on muscle function in a recovery model of critical illness (2014) (0)
Management of diabetic ketoacidosis (2022) (0)
Chapter 38 Death and the dying patient (2009) (0)
Sepsis hysteria? Not for children – Authors' reply (2020) (0)
Senior author's reply (2014) (0)
COMPARISON OF DDAH-1 INHIBITION AND NOS INHIBITIOR L-NMMA IN AN ENDOTOXAEMIC RAT MODEL (2009) (0)
A185 Infrared thermal imaging of the hand during vascular occlusion in healthy volunteers (2016) (0)
Utilising mass cytometry with CD45 barcoding and standardised leucocyte phenotyping for immune trajectory assessment in critically ill patients. (2021) (0)
G.P.68: Mitochondrial heat maps: A novel quantitative image analysis tool for assessing mitochondrial biogenesis in muscle biopsies (2015) (0)
Chapter 6 Nutrition and metabolic therapy (2009) (0)
Comparison of aconitase activity in patients and a rat model of septic shock (2002) (0)
Etomidate versus ketamine for sedation in acutely ill patients (2009) (0)
Resistance to endotoxic shock in mice lacking natriuretic peptide receptor‐A (2008) (0)
EFFECTS OF SODIUM HYDROGEN SULPHIDE DURING ENDOTOXAEMIA (2009) (0)
CHARACTERISATION OF A FLUID RESUSCITATED MODEL OF FECAL PERITONITIS WITH CONTINUOUS BLOOD PRESSURE MONITORING IN A CONSCIOUS MOUSE (2009) (0)
PROTECTION AGAINST SEPSIS-ASSOCIATED CHOLESTASIS DESPITE AGGRAVATED HEPATOCELLULAR INJURY BY SELECTIVE KNOCK-OUT OF PHOSPHOINOSITIDE 3-KINASE GAMMA (2011) (0)
Prediction of Postoperative Cardiac Surgical Morbidity and Organ Failure at Admission to the Intensive Care Unit Using Esophageal Doppler Ultrasonography (2000) (0)
EFFICACY OF TETRATHIOMOLYBDATE, A SULPHIDE DONOR, IN A RAT MODEL OF SEVERE HAEMORRHAGE/REPERFUSION INJURY (2013) (0)
c linical investigations in critical care Hemodynamic Effects of Manual Hyperinflation in Critically Ill Mechanically Ventilated Patients * (2007) (0)
Short course monotherapy for ICU-acquired gram-negative bacteraemia (2001) (0)
P2X(7) RECEPTOR AND SEPSIS- INDUCED ACUTE TUBULAR INJURY (2012) (0)
A NOVEL DDAH1 INHIBITOR IMPROVES SURVIVAL IN A LONG TERM CONSCIOUS MODEL OF SEPTIC SHOCK (2009) (0)
0371. Temporal changes in systemic and renal inflammation and histology in a 72-hour rat model of faecal peritonitis (2014) (0)
Chapter 7 Wound and pressure area management (2009) (0)
METABOLIC MODULATION BY TETRATHIOMOLYBDATE, A SLOW-RELEASE SULPHME DONOR (2012) (0)
Risk Assessment with Gene Expression Markers in Sepsis Development (2022) (0)
Management of parenchymal haemorrhage. (2016) (0)
PNAS Plus Significance Statements (2015) (0)
Changes in Cardiac Output Measured by Oesophageal Doppler; Validation using Thermodilution as the Reference Technique (1988) (0)
Could SOFA score differentiate survivors from non-survivors in bacteraemic patients? (2002) (0)
MRSA clearance during treatment with Linezolid (2002) (0)
Guidelines on the diagnosis and treatment of acute heart failure — full (2005) (0)
Loss and recovery of complement regulatory function in response to ocular pathogens (1996) (0)
S54 Preservation of mitochondrial oxidative capacity in critically ill patients balances reduction in mitochondrial biogenesis (2013) (0)
Mitochondrial dysfunction in a rodent model of sepsis and multi organ dysfunction (2002) (0)
Comparison of renal replacement therapy and renal recovery before and during the COVID-19 pandemic- A single centre observational study (2020) (0)
OXYGEN DELIVERY IS NOT CREATED EQUAL: CARDIORESPIRATORY AND STRESS RESPONSES IN DIFFERENT SHOCK STATES (2011) (0)
A Simple Prognostic Score to Predict Short and Long-Term Survival Following ICU Admission in Critically Ill Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients: Improved Survival Following Reduced Intensity Conditioning (2011) (0)
Chapter 20 Miscellaneous drugs (2009) (0)
Sterile bred rats for studies involving septic challenges have differing levels of endogenous immunity to endotoxin core (2000) (0)
Chapter 26 Hepatic disorders (2009) (0)
Central venous catheter-related bacteraemia: epidemiology, risk factors illness severity & therapy (2002) (0)
Septic shock and mitochondrial dysfunction (2001) (0)
Chapter 9 Cardiovascular monitoring (2009) (0)
Audit of bacteraemia management in a university hospital ICU (2014) (0)
Ocular complement decay-accelerating factor in health and disease (1990) (0)
Intracerebral hemorrhage in ICU: is it worth treating? (2016) (0)
Diagnosis and assessment of stroke. (2016) (0)
Sepsis and Septic Shock (2022) (0)
Mitochondrial Dynamics and Oxidative Stress Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics ( but not UCP 3 ) in a rodent model of sepsis (2015) (0)
MRSA clearance during treatment with Linezolid. [Abstract PS133] (2002) (0)
NITRIC OXIDE METABOLISM AND HYPOXIC VASODILATION (2011) (0)
How do you prefer your resuscitation solution? Do you want a little bit more salt? (2012) (0)
Additional file 1: of Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study (2016) (0)
Epidemiology of stroke (2016) (0)
UK vs Italy: Differing styles for treating bacteraemia.... But who's right? (2002) (0)
Erratum to: Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges (2013) (0)
ICU admission and discharge criteria-Oxford Medicine (2022) (0)
Comprar ABC Of Intensive Care | G. Nimmo | 9781405178037 | Wiley (2011) (0)
Antibiotic prescribing policies for bacteraemia: a North-South European divide (2002) (0)
DIFFERING STRATEGIES FOR ANTIBIOTIC PRESCRIBING FOR BACTERAEMIA IN ICU PATIENT.: 116-M (2005) (0)
Original Contribution Nitrosyl heme production compared in endotoxemic and hemorrhagic shock (2005) (0)
Chapter 31 Infection and inflammation (2009) (0)
Chapter 34 Pain and post-operative critical care (2009) (0)

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