Michael B. Kastan
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Michael B. Kastanphilosophy Degrees
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Philosophy Biology
Michael B. Kastan's Degrees
- Masters Medicine University of California, San Francisco
- PhD Biochemistry University of California, San Francisco
Why Is Michael B. Kastan Influential?
(Suggest an Edit or Addition)Michael B. Kastan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Participation of p53 protein in the cellular response to DNA damage. (1991) (3972)
- DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation (2003) (3483)
- A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia (1992) (3220)
- Cell-cycle checkpoints and cancer (2004) (2751)
- Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. (1998) (2127)
- Cell cycle control and cancer. (1994) (1900)
- Wild-type p53 is a cell cycle checkpoint determinant following irradiation. (1992) (1849)
- The complexity of p53 modulation: emerging patterns from divergent signals. (1998) (1373)
- Conversion of Bcl-2 to a Bax-like death effector by caspases. (1997) (1155)
- Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. (1994) (976)
- DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways (1994) (921)
- DNA damage induces phosphorylation of the amino terminus of p53. (1997) (905)
- The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. (2010) (837)
- ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway (2000) (835)
- Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members* (1999) (814)
- The many substrates and functions of ATM (2000) (805)
- ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. (2001) (782)
- Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks (2006) (669)
- Regulation of p53 Translation and Induction after DNA Damage by Ribosomal Protein L26 and Nucleolin (2005) (635)
- ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS (2010) (631)
- Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation (2001) (596)
- Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation (1997) (557)
- Modulation of cell death by Bcl-XL through caspase interaction. (1998) (543)
- Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. (1993) (525)
- Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation (2002) (522)
- Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. (2002) (503)
- Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c * (1999) (490)
- Autophagy links inflammasomes to atherosclerotic progression. (2012) (490)
- Initiating Cellular Stress Responses (2004) (489)
- Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways (2002) (476)
- Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair (2007) (468)
- Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. (2004) (428)
- Growth factor modulation of p53-mediated growth arrest versus apoptosis. (1995) (426)
- The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response (2004) (401)
- Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. (1993) (364)
- p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. (1994) (358)
- Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation (2001) (350)
- The DNA damage response: implications for tumor responses to radiation and chemotherapy. (2015) (349)
- Abeloff's Clinical Oncology (2013) (327)
- ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS (2015) (319)
- Strategies for optimizing the response of cancer and normal tissues to radiation (2013) (319)
- p53 and ATM: cell cycle, cell death, and cancer. (1997) (318)
- P53, cell cycle control and apoptosis: Implications for cancer (1995) (314)
- ATM: genome stability, neuronal development, and cancer cross paths. (2001) (312)
- Mitochondrial dysfunction in ataxia-telangiectasia. (2012) (305)
- Tumor-suppressor p53: implications for tumor development and prognosis. (1998) (300)
- Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. (1994) (295)
- Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. (2008) (285)
- Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1 (2000) (283)
- Interaction of FANCD2 and NBS1 in the DNA damage response (2002) (278)
- The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia. (1994) (277)
- Multiple roles of ATM in monitoring and maintaining DNA integrity (2010) (249)
- Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. (2008) (245)
- ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. (2006) (237)
- Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. (2008) (220)
- Inactivation of the Human Papillomavirus E6 or E7 Gene in Cervical Carcinoma Cells by Using a Bacterial CRISPR/Cas RNA-Guided Endonuclease (2014) (214)
- The p53-dependent γ-Ray Response of GADD45 (1994) (213)
- Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. (2002) (213)
- DNA Damage Responses: Mechanisms and Roles in Human Disease (2008) (189)
- Three paths to stress relief (1996) (174)
- The ATM-dependent DNA damage signaling pathway. (2005) (169)
- Fragments of ATM which have dominant-negative or complementing activity (1997) (167)
- Wild-Type p53: Tumors Can't Stand It (2007) (166)
- ATM binds to β-adaptin in cytoplasmic vesicles (1998) (163)
- Ionizing radiation activates the ATM kinase throughout the cell cycle (2000) (161)
- ATM Activation in Normal Human Tissues and Testicular Cancer (2005) (159)
- Participation of p 53 Protein in the Cellular Response to DNA Damage 1 (2006) (157)
- Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation (2004) (141)
- A TSC signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS (2013) (141)
- BRCA1 Is Required for Common-Fragile-Site Stability via Its G2/M Checkpoint Function (2004) (129)
- Reversal of apoptosis by the leukaemia-associated E2A–HLF chimaeric transcription factor (1996) (128)
- Interactions of Nucleolin and Ribosomal Protein L26 (RPL26) in Translational Control of Human p53 mRNA* (2012) (125)
- 5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage. (2010) (125)
- The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization. (1996) (111)
- Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells (1990) (106)
- Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair (2013) (106)
- Wild-type p 53 is a cell cycle checkpoint determinant following irradiation ( y irradiation / DNA damage / DNA replicatlon / carcinogenesis (105)
- Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology (2016) (103)
- Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA (1982) (103)
- Topoisomerase II levels during granulocytic maturation in vitro and in vivo. (1991) (100)
- Influence of ATM function on telomere metabolism (1997) (99)
- Loss of atm radiosensitizes multiple p53 null tissues. (1998) (98)
- Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. (1996) (93)
- Role of p53 in apoptosis. (1997) (93)
- The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. (2005) (93)
- DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis. (1994) (86)
- The p53-dependent gamma-ray response of GADD45. (1994) (83)
- NAD+ Modulates p53 DNA Binding Specificity and Function (2004) (82)
- Disappearance of the Telomere Dysfunction-Induced Stress Response in Fully Senescent Cells (2004) (77)
- Induction of apoptosis by tumor suppressor genes and oncogenes. (1995) (77)
- Phosphorylation of SMC 1 is a critical downstream event in the ATM – NBS 1 – BRCA 1 pathway (2004) (72)
- Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. (2003) (71)
- ATM binds to beta-adaptin in cytoplasmic vesicles. (1998) (71)
- Control of G1 arrest after DNA damage. (1993) (71)
- A Novel ATM-Dependent Pathway Regulates Protein Phosphatase 1 in Response to DNA Damage (2008) (70)
- Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells (2017) (70)
- Rad17 recruits the MRE11‐RAD50‐NBS1 complex to regulate the cellular response to DNA double‐strand breaks (2014) (69)
- ATM--a key determinant of multiple cellular responses to irradiation. (2001) (69)
- Human smooth muscle α-actin gene is a transcriptional target of the p53 tumor suppressor protein (1998) (68)
- A new role for ATM (2012) (66)
- The role of p53 in cell-cycle control and apoptosis: implications for cancer. (1995) (65)
- Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers. (2017) (61)
- Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites (2008) (59)
- Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B‐cell type (1993) (59)
- Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. (2007) (56)
- Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. (1996) (56)
- Multiple signaling pathways involving ATM. (2000) (55)
- On the TRAIL from p53 to apoptosis? (1997) (55)
- Cancer: A radical approach to treatment (2000) (55)
- Signal transduction. Three paths to stress relief. (1996) (54)
- Chromatin perturbations during the DNA damage response in higher eukaryotes. (2015) (53)
- p53: a two-faced cancer gene (2007) (50)
- Human T-Cell Leukemia Virus Type 1 Tax Attenuates the ATM-Mediated Cellular DNA Damage Response (2008) (50)
- Atm Deficiency Affects Both Apoptosis and Proliferation to Augment Myc-Induced Lymphomagenesis (2007) (49)
- p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. (1997) (47)
- Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells (1997) (45)
- Molecular cross-talk among chromosome fragility syndromes. (2004) (44)
- The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair (2014) (44)
- Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint. (1997) (43)
- Distribution of repair-incorporated nucleotides and nucleosome rearrangement in the chromatin of normal and xeroderma pigmentosum human fibroblasts. (1979) (42)
- HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism (2015) (40)
- Cell cycle: Checking two steps (2001) (40)
- Parc-ing p53 in the Cytoplasm (2003) (38)
- Expression of protooncogene c-myb in normal human hematopoietic cells (1989) (38)
- Checkpoint controls and cancer (1997) (38)
- Signalling to p53: where does it all start? (1996) (36)
- Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. (2004) (34)
- Development of a Cell-Based, High-Throughput Screening Assay for ATM Kinase Inhibitors (2014) (34)
- Abeloff's Clinical Oncology (5th ed.) (2014) (33)
- Similarity of the DNA-damage responsiveness and growth-suppressive properties of waf1/cip1 and gadd45. (1995) (32)
- Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents. (2016) (31)
- Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein. (1998) (31)
- Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells (2001) (30)
- Phosphatases join kinases in DNA-damage response pathways. (2004) (29)
- Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis (1998) (28)
- Molecular determinants of sensitivity to antitumor agents. (1999) (27)
- Analyzing cell cycle checkpoints after ionizing radiation. (2004) (26)
- Genetic Instability and Tumorigenesis (2011) (25)
- P53: a determinant of the cell cycle response to DNA damage. (1993) (23)
- Pilot study of modified LMB‐based therapy for children with ataxia–telangiectasia and advanced stage high grade mature B‐cell malignancies (2014) (22)
- Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. (2015) (21)
- Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia. (2010) (20)
- Abeloff's Clinical Oncology: Fifth Edition (2013) (17)
- A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. (2006) (16)
- Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate. (1996) (15)
- HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia–telangiectasia cellular phenotype (2003) (15)
- Defective potassium currents in ataxia telangiectasia fibroblasts. (1998) (14)
- Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness (2019) (13)
- Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. (2012) (13)
- Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia (2020) (12)
- Commentary on "Participation of p53 Protein in the Cellular Response to DNA Damage". (2016) (12)
- The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein. (1995) (11)
- Expression and assay of recombinant ATM. (2000) (11)
- Our cells get stressed too! Implications for human disease. (2007) (10)
- DNA Damage Response Pathways and Cancer (2020) (9)
- DNA-Damage-Induced Alternative Splicing of p53 (2021) (9)
- Genetic instability and tumorigenesis: introduction. (1997) (9)
- Cell biology: A BID for the pathway (2005) (9)
- Distribution of 5-methyldeoxycytidine in products of staphylococcal nuclease digestion of nuclei and purified DNA. (1985) (8)
- Experimental models of human carcinogenesis (1993) (8)
- Levels of p 53 Protein Increase with Maturation in Human Hematopoietic Cells 1 (2006) (6)
- 5 9 –3 9 -UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage (2010) (6)
- ATM–the first step in helping cells deal with DNA damage☆ (2004) (6)
- Checkpoint controls and cancer. Introduction. (1997) (5)
- Cellular survival pathways and resistance to cancer therapy. (1998) (5)
- Rad 17 recruits the MRE 11-RAD 50-NBS 1 complex to regulate the cellular response to DNA double-strand breaks (2014) (5)
- Erratum: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS (Proceedings of the National Academy of Sciences (2010) 107 (4153-4158) DOI: 10.1073/pnas.0913860107) (2012) (4)
- Transactivation Apoptosis from p 53-Dependent of Transcriptional Repression and Regulation of p 53 by Hypoxia : Dissociation (2001) (4)
- To oxidize or not to oxidize? (1997) (3)
- Comprar Abeloff's Clinical Oncology Expert Consult Premium Edition: Enhanced Online Features and Print | W. Gillies McKenna | 9780443066955 | Churchill Livingstone (2008) (3)
- Abstract 4831: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 and autophagy in response to ROS (2010) (3)
- Comprar Abeloff´s Clinical Oncology - Expert consult print + online | W. Gillies McKenna | 9780443066948 | Churchill Livingstone (2008) (3)
- Retrospective Diagnosis of Ataxia-Telangiectasia in an Adolescent Patient With a Remote History of T-Cell Leukemia. (2019) (2)
- Welcome to Molecular Cancer Research (2002) (1)
- Chloroquine Activates ATM and Improves Hematopoietic Recovery and Survival of Mice following Low Dose-rate Radiation (2011) (1)
- Ataxia-Telangiectasia: Defective in a P53-Dependent Signal Transduction Pathway (1993) (1)
- Abstract 4: 5' - 3' UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage (2010) (1)
- 20 Years of DNA Damage Signaling to p53 (2007) (1)
- The p53-dependent -y-Ray Response of GADD451 (2011) (1)
- DNA damage responses : Cancer and beyond (2005) (1)
- A novel ATM-dependent pathway regulates PP1 activation and the G2/M checkpoint in response to DNA damage (2008) (0)
- ATM Regulation of the Cohesin Complex is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double Strand Breaks. (2022) (0)
- Duke University Global Cancer Program: A multidisciplinary approach to partnerships in global cancer care. (2015) (0)
- Methodes de regulation de la traduction des p53 et fonctions associees (2006) (0)
- Molecular Controls of Cell Cycle Progression Following DNA Damage: Roles of P53 and Ataxia-Telangiectasia Gene Products (1994) (0)
- 245 Targeting ATM and p53 (2010) (0)
- ATM activation is a marker of cellular aging and a precursor to replicative senescence. (2004) (0)
- Replication Protein A from the S-Phase Checkpoint Dissociation of Radiation-induced Phosphorylation of Updated (2006) (0)
- How to Survive Medical School (1984) (0)
- Abstract 3086: Interactions of nucleolin and ribosomal protein RPL26 in the translational control of human p53 mRNA (2011) (0)
- ATM and p53 are potential mediators of Chloroquine-induced resistance to mammary carcinogenesis (2008) (0)
- Are Induced by Ionizing Irradiation / M Checkpoints 2 Two Molecularly Distinct G (2002) (0)
- Abstract IA11: New insights into DNA double-strand break responses (2014) (0)
- A Message from the Editor-in-Chief (2012) (0)
- A novel DNA damage-induced alternative splicing pathway that regulates p53 and cellular senescence markers (2017) (0)
- 11 Unexpected New Insights Into ATM and p53 (2012) (0)
- Cell cycle and cell death after DNA damaye (1997) (0)
- target for modulating p 53 induction after DNA damage-UTR interactions regulate p 53 mRNA translation and provide a ′ 3 − ′ 5 Material Supplemental (2010) (0)
- Books and Media Reviews (2000) (0)
- Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway (2023) (0)
- Human T-Cell Leukemia Virus Type 1 Tax Attenuates the ATM-Mediated Cellular DNA Damage Response (cid:1) (2008) (0)
- Roles of TP53 and ATM in Radiation Responses (1999) (0)
- Carcinogenesis Mediators of Chloroquine-Induced Resistance to Mammary Ataxia Telangiectasia-Mutated and p53 Are Potential (2007) (0)
- Abstract IA08: Ataxia-telangiectasia: Broad implications from the study of a rare disease (2014) (0)
- Leaders Apoptosis in haematological malignancies (0)
- Compositions et procedes de kinase atm (2003) (0)
- mTOR signaling is regulated by TSC2 at the peroxisome (2008) (0)
- Editor's Note (2007) (0)
- Abstract PL04-02: ATM: Bridging DNA damage responses and metabolic regulation (2015) (0)
- Impaired Endoplasmic Reticulum (ER)-Mitochondrial Signaling in Ataxia-Telangiectasia Contributes to Mitochondrial Dysfunction (2020) (0)
- A Message from the Editor (2007) (0)
- Abstract IA17: Non-canonical aspects of ATM and p53 signaling pathways (2017) (0)
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What Schools Are Affiliated With Michael B. Kastan?
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