Michael Botchan
#101,985
Most Influential Person Now
Researcher
Michael Botchan's AcademicInfluence.com Rankings
Michael Botchanbiology Degrees
Biology
#6152
World Rank
#8808
Historical Rank
Molecular Biology
#1259
World Rank
#1286
Historical Rank
Biochemistry
#1591
World Rank
#1723
Historical Rank
Download Badge
Chemistry Biology
Michael Botchan's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Michael Botchan Influential?
(Suggest an Edit or Addition)According to Wikipedia, Michael Botchan is a professor of biochemistry and molecular biology at the University of California, Berkeley, where his research focuses on regulation of DNA replication during cell division. Botchan is a member of the United States National Academy of Sciences and the American Academy of Arts and Sciences and was appointed as the dean of the university's Division of Biological Sciences in 2017.
Michael Botchan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The genome sequence of Drosophila melanogaster. (2000) (6125)
- Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase (2006) (720)
- A prudent path forward for genomic engineering and germline gene modification (2015) (565)
- Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. (2010) (534)
- Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences (1981) (440)
- The arrangement of simian virus 40 sequences in the DNA of transformed cells (1976) (428)
- Association of the Origin Recognition Complex with Heterochromatin and HP1 in Higher Eukaryotes (1997) (423)
- Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator. (1990) (423)
- The structural basis for MCM2–7 helicase activation by GINS and Cdc45 (2011) (329)
- The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication (1993) (319)
- Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transition (2011) (304)
- Activation of BPV-1 replication in vitro by the transcription factor E2 (1991) (293)
- Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription (1991) (285)
- High mutation frequency in DNA transfected into mammalian cells. (1983) (276)
- Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. (2004) (266)
- The retinoblastoma gene product regulates Sp1-mediated transcription (1992) (256)
- DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC–DNA binding (2004) (247)
- The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase. (1993) (246)
- Role for a Drosophila Myb-containing protein complex in site-specific DNA replication (2002) (230)
- Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation. (1998) (201)
- Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. (2011) (192)
- Association of crossover points with topoisomerase I cleavage sites: a model for nonhomologous recombination. (1985) (189)
- Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome. (1989) (187)
- Characterization of the Bovine Papilloma virus plasmid maintenance sequences (1984) (187)
- The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase. (1994) (183)
- The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. (2004) (169)
- Studies on simian virus 40 excision from cellular chromosomes. (1979) (156)
- A Drosophila Homolog of the Yeast Origin Recognition Complex (1995) (155)
- Genetic analysis of bovine papillomavirus type 1 trans-acting replication factors (1985) (152)
- Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. (2007) (147)
- Viral DNA sequences in cells transformed by simian virus 40, adenovirus type 2 and adenovirus type 5. (1975) (146)
- Orc mutants arrest in metaphase with abnormally condensed chromosomes. (2001) (145)
- Mechanisms for initiating cellular DNA replication (2017) (144)
- Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit (1983) (140)
- Bovine papillomavirus type 1 encodes two forms of a transcriptional repressor: structural and functional analysis of new viral cDNAs (1989) (138)
- Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell (1980) (135)
- Integration and excision of SV40 DNA from the chromosome of a transformed cell (1980) (133)
- Distinct Cytoplasmic and Nuclear Fractions of Drosophila Heterochromatin Protein 1: Their Phosphorylation Levels and Associations with Origin Recognition Complex Proteins (1998) (126)
- Functional analysis of mutant and wild-type Drosophila origin recognition complex (2001) (126)
- Mechanisms and regulation of DNA replication initiation in eukaryotes (2017) (125)
- Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association. (2006) (125)
- CRISPR germline engineering—the community speaks (2015) (124)
- Biochemical and Electron Microscopic Image Analysis of the Hexameric E1 Helicase* (1999) (123)
- Expression of enhanced levels of small RNA polymerase III transcripts encoded by the B2 repeats in simian virus 40-transformed mouse cells (1985) (120)
- Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1. (1994) (119)
- DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome (2014) (118)
- p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner (1996) (116)
- A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity (2003) (110)
- Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner. (1997) (108)
- Crystal Structure of the Eukaryotic Origin Recognition Complex (2015) (107)
- Transformation mediated by the SV40 T antigens: Separation of the overlapping SV40 early genes with a retroviral vector (1984) (101)
- Assembly of functionally active Drosophila origin recognition complex from recombinant proteins. (1999) (100)
- Isolation and characterization of T antigen-negative revertants from a line of transformed rat cells containing one copy of the SV40 genome (1978) (100)
- The minichromosome maintenance replicative helicase. (2013) (96)
- The eukaryotic chromosome. (1970) (94)
- Identification of a 68-kilodalton nuclear ATP-binding phosphoprotein encoded by bovine papillomavirus type 1 (1990) (93)
- Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. (2007) (92)
- Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex (2006) (88)
- Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. (2004) (87)
- DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects (1993) (85)
- Repression of bovine papilloma virus replication is mediated by a virally encoded Trans-acting factor (1986) (84)
- Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement (2015) (82)
- Transient replication of bovine papilloma virus type 1 plasmids: cis and trans requirements. (1986) (82)
- Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes. (2010) (80)
- Effects of poly[d(pGpT).d(pApC)] and poly[d(pCpG).d(pCpG)] repeats on homologous recombination in somatic cells (1986) (79)
- Bovine satellite I DNA consists of repetitive units 1,400 base pairs in length (1974) (78)
- DNA sequence studies of simian virus 40 chromosomal excision and integration in rat cells. (1984) (77)
- Enhanced transformation by a simian virus 40 recombinant virus containing a Harvey murine sarcoma virus long terminal repeat (1983) (77)
- The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops. (1991) (76)
- Origin recognition complex binding to a metazoan replication origin (2001) (73)
- The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site (1993) (73)
- Induction of specific transcription by RNA polymerase III in transformed cells (1986) (72)
- Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication (1996) (72)
- ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote (2012) (71)
- Replication of bovine papillomavirus type 1 DNA initiates within an E2-responsive enhancer element (1990) (70)
- Arrangement of the highly reiterated DNA sequences in the centric heterochromatin of Drosophila melanogaster. Evidence for interspersed spacer DNA. (1972) (70)
- Crystal structure of the human papillomavirus type 18 E2 activation domain. (1999) (69)
- A promoter with an internal regulatory domain is part of the origin of replication in BPV-1. (1987) (66)
- Isolation and characterization of human DNA fragments with nucleotide sequence homologies with the simian virus 40 regulatory region (1982) (63)
- Separation of Origin Recognition Complex Functions by Cross-Species Complementation (1995) (62)
- A new class of disordered elements controls DNA replication through initiator self-assembly (2019) (61)
- Isolation and chromosomal localization of highly repeated DNA sequences in Drosophila melanogaster. (1971) (60)
- Analysis of the sites of integration of viral DNA sequences in rat cells transformed by adenovirus 2 or SV40. (1980) (58)
- Ends of bacteriophage Mu DNA (1976) (58)
- Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome (2019) (52)
- Transcription factor E2 regulates BPV-1 DNA replication in vitro by direct protein-protein interaction. (1991) (52)
- Complementation of a bovine papilloma virus low-copy-number mutant: evidence for a temporal requirement of the complementing gene (1986) (52)
- The E2 trans-activator can act as a repressor by interfering with a cellular transcription factor. (1990) (52)
- A bovine papillomavirus type 1-encoded modulator function is dispensable for transient viral replication but is required for establishment of the stable plasmid state (1986) (52)
- cis-Acting components of human papillomavirus (HPV) DNA replication: linker substitution analysis of the HPV type 11 origin (1995) (51)
- Cleavage of mouse DNA by a restriction enzyme as a clue to the arrangement of genes. (1974) (49)
- Another chromosomal assignment for a simian virus 40 integration site in human cells. (1978) (48)
- An enhancer sequence from bovine papilloma virus DNA consists of two essential regions. (1984) (47)
- A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation (2013) (46)
- The bovine papilloma virus E1 protein has ATPase activity essential to viral DNA replication and efficient transformation in cells. (1994) (42)
- DNA Replication: A familiar ring to DNA polymerase processivity (1995) (41)
- Competition for DNA Binding Sites between the Short and Long Forms of E2 Dimers Underlies Repression in Bovine Papillomavirus Type 1 DNA Replication Control (1998) (41)
- Isolation of cellular genes differentially expressed in mouse NIH 3T3 cells and a simian virus 40-transformed derivative: growth-specific expression of VL30 genes (1985) (41)
- The product of the bovine papillomavirus type 1 modulator gene (M) is a phosphoprotein (1988) (39)
- A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention (1997) (39)
- Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping. (2008) (38)
- Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex (2012) (38)
- Retransformation of a simian virus 40 revertant cell line, which is resistant to viral and DNA infections, by microinjection of viral DNA (1979) (37)
- CDK Phosphorylation Inhibits the DNA-binding and ATP-hydrolysis Activities of the Drosophila Origin Recognition Complex* (2005) (36)
- Characterization of Simian Virus 40 T-antigen Double Hexamers Bound to a Replication Fork (2002) (36)
- Coordinating DNA replication with cell division: current status of the licensing concept. (1996) (35)
- humpty dumpty Is Required for Developmental DNA Amplification and Cell Proliferation in Drosophila (2005) (32)
- trans Activation of the simian virus 40 enhancer (1986) (32)
- E1 recognition sequences in the bovine papillomavirus type 1 origin of DNA replication: interaction between half sites of the inverted repeats (1995) (31)
- DNA-mediated gene transfer efficiency is enhanced by ionizing and ultraviolet irradiation of rodent cells in vitro. I. Kinetics of enhancement. (1985) (30)
- Viral DNA in transformed cells. III. The amounts of different regions of the SV40 genome present in a line of transformed mouse cells. (1974) (29)
- Fragment spanning the SV40 replication origin is the only DNA sequence required in cis for viral excision. (1982) (28)
- Assembly of nucleosomes: do multiple assembly factors mean multiple mechanisms? (1994) (27)
- The E2 transactivator of bovine papillomavirus type 1 is expressed from multiple promoters (1990) (27)
- The bovine papillomavirus replicon. (1986) (27)
- E1 Protein of Bovine Papillomavirus Type 1 Interferes with E2 Protein-Mediated Tethering of the Viral DNA to Mitotic Chromosomes (2002) (27)
- Conformational control and DNA-binding mechanism of the metazoan origin recognition complex (2018) (25)
- Simian virus 40 T antigen is required for viral excision from chromosomes. (1984) (24)
- A deletion in the simian virus 40 large T antigen impairs lytic replication in monkey cells in vivo but enhances DNA replication in vitro: new complementation function of T antigen (1992) (23)
- DNA replication: making two forks from one prereplication complex. (2010) (23)
- Simian virus 40-transformed human cells that express large T antigens defective for viral DNA replication (1987) (23)
- Hitchhiking without Covalent Integration (2004) (22)
- DNA tumor viruses: control of gene expression and replication : abstracts of papers presented at the Third Cold Spring Harbor Meeting on Cancer Cells, September 4-September 8, 1985 (1985) (21)
- Competition between pentalysine and actinomycin D for binding to DNA. (1972) (19)
- The El Replication Protein of Bovine Papillomavirus Type 1 Contains an Extended Nuclear Localization Signal That Includes a p 34 cdC 2 Phosphorylation Site (18)
- Cell biology: A switch for S phase (2007) (17)
- Site-specific DNA-binding proteins important for replication and transcription have multiple activities. (1993) (16)
- Chromatin reader L(3)mbt requires the Myb–MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment (2014) (15)
- Structural Mechanisms for Replicating DNA in Eukaryotes. (2021) (14)
- The E2 trans-activator can act as a repressor by interfering with a cellular transcription factor. (1990) (14)
- The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain. (2000) (13)
- Drosophila Lin-52 Acts in Opposition to Repressive Components of the Myb-MuvB/dREAM Complex (2012) (12)
- Integration of viral DNA sequences in cells transformed by adenovirus 2 or SV40 (1980) (11)
- Amplification of a bovine papillomavirus-simian virus 40 chimera (1985) (11)
- Characterization of SV40 DNA rescued from transformed mouse cells. (1975) (6)
- The use of buoyant density profiles in determining the length and spacing of repeated sequences in DNA. (1973) (6)
- A genome analysis of endoreplication in the Drosophila ovary. (2004) (5)
- Deoxyribonucleic acid renaturation kinetics and hybridization. Probe to the structure of the eukaryotic chromosome (1973) (4)
- DNA Mediated Gene Transfer: Theory and Application (1980) (4)
- Molecular determinants of phase separation for Drosophila DNA replication licensing factors (2021) (3)
- A constitutive enhancer in the bovine papillomavirus upstream regulatory region shares genetic elements with the viral P1 promoter (1992) (3)
- Induction ofSpecific Transcription byRNA Polymerase IIIin Transformed Cells (1986) (2)
- 1 Molecular determinants of phase separation for Drosophila DNA replication licensing factors 1 2 (2021) (0)
- Drosophila Homolog of Yeast ORC: Correction. (1996) (0)
- Crystal Structure of the Papillomavirus DNA Tethering Complex E2:Brd4 (2007) (0)
- PANEL DISCUSSION (1949) (0)
- Drosophila homolog of yeast ORC: correction. (1996) (0)
- The occurrence of highly reiterated DNA sequences in the genome of "Drosophila melanogaster". I. Isolation. (1971) (0)
- Faculty Opinions recommendation of Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. (2010) (0)
- Editor's evaluation: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae (2021) (0)
- IDENTIFYING INHIBITORS OF PAPLLOMA VIRUS REPLICATION (2017) (0)
- Acidic blobs target replication factor A (1993) (0)
- Faculty Opinions recommendation of Heterochromatin links to centromeric protection by recruiting shugoshin. (2008) (0)
- The occurrence of highly reiterated DNA sequences in the genome of "Drosophila melanogaster". 3. Chromosomal localization by hybridization "in situ". (1971) (0)
- A Deletion intheSimianVirus40LargeT Antigen Impairs Lytic Replication inMonkeyCells InVivobutEnhances DNA Replication InVitro: New Complementation Function ofT Antigen (1992) (0)
- The occurrence of highly reiterated DNA sequences in the genome of "Drosophila melanogaster". II. Kinetics of reassociation. (1971) (0)
- Coordinating DNA replication with licensing concept (2016) (0)
- Deciphering the Functional Role of Bacterial H-NOX Proteins By Charles William Hespen A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy (2016) (0)
- Abstracts of papers presented at the 1978 Tumor Virus Meeting on SV40, Polyoma, and Adenoviruses, July 26-July 30, 1978 (1978) (0)
- The use of buoyant density profiles in determining the length and spacing of repeated sequences in DNA. (1973) (0)
- The condensation of interphase chromatin to form the discrete packages of DNA for segregation during mitosis is one of the more dramatic events in the cell cycle. The metaphase chromosome in metazoans is thought to be formed by a series (2001) (0)
- Faculty Opinions recommendation of Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. (2010) (0)
- Decision letter: A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding (2019) (0)
- Abstracts of papers presented at the 1984 Tumor Virus Meeting on SV40, Polyoma, and Adenoviruses, August 15-August 19, 1984 (1984) (0)
- Decision letter: DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7 (2021) (0)
This paper list is powered by the following services:
Other Resources About Michael Botchan
What Schools Are Affiliated With Michael Botchan?
Michael Botchan is affiliated with the following schools:
