Michael Butler
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Michael Butlerengineering Degrees
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Electrical Engineering
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Michael Butlercomputer-science Degrees
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Machine Learning
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Engineering Computer Science
Michael Butler's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
- Bachelors Computer Engineering University of California, Berkeley
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(Suggest an Edit or Addition)Michael Butler's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals (2005) (468)
- Expression systems for therapeutic glycoprotein production. (2009) (355)
- Growth inhibition in animal cell culture (1991) (245)
- Effects of ammonia on CHO cell growth, erythropoietin production, and glycosylation. (2000) (217)
- Review of dengue virus and the development of a vaccine. (2011) (192)
- Recent advances in technology supporting biopharmaceutical production from mammalian cells (2012) (185)
- Optimisation of the Cellular Metabolism of Glycosylation for Recombinant Proteins Produced by Mammalian Cell Systems (2006) (183)
- Enhanced Production of Monomeric Interferon‐β by CHO Cells through the Control of Culture Conditions (2008) (153)
- The choice of mammalian cell host and possibilities for glycosylation engineering. (2014) (148)
- Dissolved oxygen concentration in serum-free continuous culture affects N-linked glycosylation of a monoclonal antibody. (1998) (139)
- Effects of Ammonia and Glucosamine on the Heterogeneity of Erythropoietin Glycoforms (2002) (135)
- Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest. (2010) (123)
- The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody. (2014) (109)
- Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture (1993) (105)
- The effect of dissolved oxygen on the production and the glycosylation profile of recombinant human erythropoietin produced from CHO cells (2006) (93)
- The effects of glutamine utilisation and ammonia production on the growth of BHK cells in microcarrier cultures (1984) (90)
- Optimization of physical parameters for cell attachment and growth on macroporous microcarriers (1996) (87)
- Comparisons of the Glycosylation of a Monoclonal Antibody Produced under Nominally Identical Cell Culture Conditions in Two Different Bioreactors (2000) (86)
- Effect of Ammonia on the Glycosylation of Human Recombinant Erythropoietin in Culture (2000) (86)
- The effect of pH on the toxicity of ammonia to a murine hybridoma. (1990) (84)
- Pluronic Enhances the Robustness and Reduces the Cell Attachment of Mammalian Cells (2008) (84)
- Nutritional aspects of the growth of animal cells in culture (1989) (83)
- Production of α2,6-sialylated IgG1 in CHO cells (2015) (80)
- High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture. (2007) (77)
- Erythropoietin production from CHO cells grown by continuous culture in a fluidized-bed bioreactor. (2002) (77)
- Effects of nutrient levels and average culture pH on the glycosylation pattern of camelid-humanized monoclonal antibody. (2014) (75)
- Animal Cell Culture and Technology (1997) (68)
- Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing. (2020) (66)
- High yields from microcarrier cultures by medium perfusion. (1983) (66)
- Application of the StrOligo algorithm for the automated structure assignment of complex N-linked glycans from glycoproteins using tandem mass spectrometry. (2003) (66)
- Effect of temperature on nucleotide pools and monoclonal antibody production in a mouse hybridoma (1994) (62)
- Adaptation to non-ammoniagenic medium and selective substrate feeding lead to enhanced yields in animal cell cultures. (1990) (62)
- Profile of energy metabolism in a murine hybridoma: Glucose and glutamine utilization (1994) (62)
- The effect of dissolved oxygen on the metabolic profile of a murine hybridoma grown in serum-free medium in continuous culture. (1997) (60)
- High productivity of human recombinant beta-interferon from a low-temperature perfusion culture. (2010) (59)
- Glutamine-based dipeptides are utilized in mammalian cell culture by extracellular hydrolysis catalyzed by a specific peptidase. (1994) (58)
- Mammalian cell biotechnology. A practical approach. (1991) (52)
- Production of reovirus type-1 and type-3 from Vero cells grown on solid and macroporous microcarriers. (1999) (51)
- Fed‐batch CHO cell t‐PA production and feed glutamine replacement to reduce ammonia production (2013) (50)
- Production and Glycosylation of Recombinant β‐Interferon in Suspension and Cytopore Microcarrier Cultures of CHO Cells (2008) (47)
- Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture. (2015) (46)
- Uptake of glutamate, not glutamine synthetase, regulates adaptation of mammalian cells to glutamine-free medium. (1993) (45)
- The adaptation of BHK cells to a non-ammoniagenic glutamate-based culture medium. (1999) (42)
- A study of immunoglobulin G glycosylation in monoclonal and polyclonal species by electrospray and matrix-assisted laser desorption/ionization mass spectrometry. (2002) (42)
- CHO cells adapted to hypothermic growth produce high yields of recombinant β‐interferon (2008) (42)
- Application of a Serum‐Free Medium for the Growth of Vero Cells and the Production of Reovirus (2000) (41)
- Inhibition of glutamine‐dependent autophagy increases t‐PA production in CHO Cell fed‐batch processes (2012) (39)
- Characterization of glutamine metabolism in two related murine hybridomas. (1992) (38)
- Glycosylation of an immunoglobulin produced from a murine hybridoma cell line: The effect of culture mode and the anti‐apoptotic gene, bcl‐2 (2007) (37)
- Application of a serum-free medium for the growth of Vero cells and the production of reovirus. (2000) (36)
- Enhanced erythropoietin heterogeneity in a CHO culture is caused by proteolytic degradation and can be eliminated by a high glutamine level (2000) (36)
- Development of an assay for the measurement of the surfactant pluronic F-68 in mammalian cell culture medium. (1998) (34)
- Growth limitations in microcarrier cultures. (1987) (34)
- Different Immunity Elicited by Recombinant H5N1 Hemagglutinin Proteins Containing Pauci-Mannose, High-Mannose, or Complex Type N-Glycans (2013) (31)
- The effect of glucose and glutamine on the intracellular nucleotide pool and oxygen uptake rate of a murine hybridoma (2000) (29)
- Enhanced Production of Human Recombinant Proteins from CHO cells Grown to High Densities in Macroporous Microcarriers (2011) (27)
- Intracellular ATP and total adenylate concentrations are critical predictors of reovirus productivity from Vero cells (2006) (26)
- Monitoring cell growth, viability, and apoptosis. (2014) (25)
- Adaptation of mammalian cells to non-ammoniagenic media (2004) (25)
- High yields of monomeric recombinant β‐interferon from macroporous microcarrier cultures under hypothermic conditions (2008) (25)
- Tuning a MAb glycan profile in cell culture: Supplementing N-acetylglucosamine to favour G0 glycans without compromising productivity and cell growth. (2015) (23)
- Glycosylation (2018) (23)
- Cell Counting and Viability Measurements (1999) (23)
- Unsaturated fatty acids enhance cell yields and perturb the energy metabolism of an antibody-secreting hybridoma. (1997) (21)
- The bioactivity and fractionation of peptide hydrolysates in cultures of CHO cells (2014) (21)
- A systematic study of glycopeptide esterification for the semi-quantitative determination of sialylation in antibodies. (2015) (20)
- The effect of fatty acids on hybridoma cell growth and antibody productivity in serum-free cultures. (1995) (20)
- The effect of alternative carbohydrates on the growth and antibody production of a murine hybridoma (1996) (20)
- Preparative separation of monoclonal antibody aggregates by cation-exchange laterally-fed membrane chromatography. (2017) (20)
- The crystal violet nuclei staining technique leads to anomalous results in monitoring mammalian cell cultures (2004) (20)
- Linoleic acid improves the robustness of cells in agitated cultures (1999) (19)
- Serum and Protein Free Media (2015) (19)
- High Genetic Stability of Dengue Virus Propagated in MRC-5 Cells as Compared to the Virus Propagated in Vero Cells (2008) (19)
- Isolation and quantification of N-glycans from immunoglobulin G antibodies for quantitative glycosylation analysis (2015) (19)
- Measurement of hydrophobic interactions of mammalian cells grown in culture. (2002) (19)
- Influenza Virus Hemagglutinin Glycoproteins with Different N-Glycan Patterns Activate Dendritic Cells In Vitro (2016) (18)
- Cell culture labfax (1992) (18)
- Increased CHO cell fed-batch monoclonal antibody production using the autophagy inhibitor 3-MA or gradually increasing osmolality (2014) (18)
- Purification of chimeric heavy chain monoclonal antibody EG2‐hFc using hydrophobic interaction membrane chromatography: An alternative to protein‐A affinity chromatography (2014) (18)
- The relationship between intracellular UDP-N-acetyl hexosamine nucleotide pool and monoclonal antibody production in a mouse hybridoma. (1998) (17)
- Components of yeast (Sacchromyces cervisiae) extract as defined media additives that support the growth and productivity of CHO cells. (2016) (16)
- Improved therapeutic efficacy of mammalian expressed‐recombinant interferon gamma against ovarian cancer cells (2017) (15)
- Effect of Culture Conditions on Glycosylation of Recombinant beta-Interferon in CHO Cells (2007) (15)
- The Role of Glycosylation in Therapeutic Antibodies (2011) (15)
- The Effect of Cell Culture Parameters on Protein Glycosylation (2002) (15)
- Animal cell culture and technology : the basics (1996) (15)
- Inhibition of glycosylation on a camelid antibody uniquely affects its Fc&ggr;RI binding activity (2017) (14)
- Effects of cysteine, asparagine, or glutamine limitations in Chinese hamster ovary cell batch and fed‐batch cultures (2019) (12)
- MDCK microcarrier cultures: Seeding density effects and amino acid utilization (1982) (11)
- The characteristics and growth of cultured cells (1991) (11)
- The use of glutamine-free media for the growth of three cell lines in microcarrier culture (1987) (11)
- Solid-Phase Enzymatic Remodeling Produces High Yields of Single Glycoform Antibodies. (2018) (11)
- Comparison of two glycoengineering strategies to control the fucosylation of a monoclonal antibody. (2020) (10)
- Glycan‐masking hemagglutinin antigens from stable CHO cell clones for H5N1 avian influenza vaccine development (2018) (10)
- A low redox potential affects monoclonal antibody assembly and glycosylation in cell culture. (2017) (10)
- An integrated approach to analyze EG2-hFc monoclonal antibody N-glycosylation by MALDI-MS (2015) (10)
- THE EFFECT OF METABOLIC BY-PRODUCTS ON ANIMAL CELLS IN CULTURE (1991) (9)
- A semi-empirical glycosylation model of a camelid monoclonal antibody under hypothermia cell culture conditions (2017) (9)
- Cell Culture and Upstream Processing (2009) (9)
- Growth limitations in high density microcarrier cultures. (1985) (9)
- Using recombinant DNA technology for the development of live-attenuated dengue vaccines. (2012) (9)
- Energy Metabolism, Microbial and Animal Cells (2002) (8)
- Glycosylation in Cell Culture (2015) (8)
- Animal cell technology : principles and products (1987) (7)
- The inhibitory effect of glutamate on the growth of a murine hybridoma is caused by competitive inhibition of the x-C transport system required for cystine utilization (2004) (7)
- Modulating antibody‐dependent cellular cytotoxicity of epidermal growth factor receptor‐specific heavy‐chain antibodies through hinge engineering (2019) (7)
- Mass spectrometric analysis of products of metabolic glycan engineering with azido-modification of sialic acids (2015) (6)
- Glycosylation analysis of Chinese hamster ovary produced glycoproteins (2014) (6)
- Serum-free media: standardizing cell culture system (2013) (6)
- The role of protein hydrolysates in prolonging viability and enhancing antibody production of CHO cells (2021) (5)
- High-throughput and high-sensitivity N-Glycan profiling: a platform for biopharmaceutical development and disease biomarker discovery. (2021) (5)
- Modes of culture for high cell densities (2004) (5)
- Animal Cell Technology (1987) (5)
- Evaluation of Quenching and Extraction Methods for Nucleotide/Nucleotide Sugar Analysis. (2015) (5)
- Decreased monoclonal IgG1 galactosylation at reduced dissolved oxygen concentration is not a result of lowered galactosyltransferase activity in vitro (2003) (5)
- Mammalian Cell Lines and Glycosylation: A Case Study (2009) (4)
- Recombinant hemagglutinin proteins formulated in a novel PELC/CpG adjuvant for H7N9 subunit vaccine development (2017) (4)
- Scientific fundamentals of biotechnology (2011) (4)
- Growth and maintenance of cells in culture (2004) (4)
- Differential affects of low glucose on the macroheterogeneity and microheterogeneity of glycosylation in CHO-EG2 camelid monoclonal antibodies (2013) (3)
- From the mold in Dr Florey’s coat to blockbuster drugs (2013) (3)
- Production of IgGs with a human-like sialylation in CHO cells (2015) (3)
- ENERGY METABOLISM OF MURINE HYBRIDOMAS (1992) (3)
- The effect of the catalytic topoisomerase II inhibitor dexrazoxane (ICRF-187) on CC9C10 hybridoma viability and productivity (2001) (3)
- Purification of rabies virus glycoprotein produced in Drosophila melanogaster S2 cells: An efficient immunoaffinity method (2020) (3)
- Hybridomas, Genetic Engineering of (2003) (3)
- Erythropoietin Production from CHO Cells Grown in a Fluidized-Bed Bioreactor with Macroporous Beads (1999) (3)
- The Modification of a Serum-Free Media Formulation for the Production of Reovirus and the Growth of Vero, MRC-5, MDCK and BHK Cell Lines (2001) (2)
- Serum-free media : standardizing cell culture systems (2013) (2)
- The attachment of MDCK cells to three types of microcarriers in different serum-free media (1987) (2)
- Strategic feeding of NS0 and CHO cell cultures to control glycan profiles and immunogenic epitopes of monoclonal antibodies. (2021) (2)
- Specific activities of glycosyltransferase enzymes vary with monoclonal antibody productivity in murine hybridomas (1993) (2)
- The glycosylation of proteins in cell culture (2004) (2)
- Applications of bio-capacitance to cell culture manufacturing. (2022) (1)
- Cell Productivity is Overestimated by the Crystal Violet Nuclei Counting Technique (1997) (1)
- Equipment and Laboratory Design for Cell Culture (2003) (1)
- Post-translational modification of recombinant proteins (2008) (1)
- THE EFFECT OF GLUTAMINE-CONTAINING DIPEPTIDES ON THE GROWTH AND PRODUCTIVITY OF A HYBRIDOMA (1994) (1)
- Cell line and culture monitoring (2004) (1)
- The Metabolic Profile of a Murine Hybridoma Grown in Serum Free Medium at Various Oxygen Concentrations (1997) (1)
- Intracellular Fatty Acid Composition Affects Cell Yield, Energy Metabolism and Cell Damage in Agitated Cultures (1998) (0)
- The Effect of Unsaturated Fatty Acids on the Growth, Metabolism and Productivity of a Murine Hybridoma (1995) (0)
- 5.1 Physiology and Metabolism of Animal Cells for Production (2014) (0)
- ADAPTATION OF ANCHORAGE-DEPENDENT CELLS TO GLUTAMINE-FREE MEDIUM (1991) (0)
- Production from cell culture (2004) (0)
- Optimisation of the Fatty Acid Composition of a Hybridoma Enhances Mab Production and Perturbs Energy Metabolism (1997) (0)
- Characteristics of cells in culture (2004) (0)
- Cell Free Remodeling of Glycosylation of Antibodies. (2022) (0)
- Protein Glycosylation: Methods for Determination (2009) (0)
- Genetic engineering of animal cells in culture (2004) (0)
- Mass spectrometric analysis of core fucosylation and sequence variation in a human-camelid monoclonal antibody. (2020) (0)
- Mammalian cell products: established and potential (2004) (0)
- Recent advances in technology supporting biopharmaceutical production from mammalian cells (2012) (0)
- Animal Cell Biotechnology: volumes 1 and 2: Editors: R.E. Spier and J.B. Griffiths Academic Press, London, 1985, Vol. 1: 347 pp., ISBN 0-12-657551-7, £49; Vol. 2, 47 pp., ISBN 0-12-657552-5, £59 (1987) (0)
- Energy Metabolism of Cells Used for Industrial Production (2010) (0)
- Measurement of Cell Viability (2003) (0)
- Hybridomas—sources of antibodies (2004) (0)
- Basic equipment and laboratory design: what you need to get started in cell culture (2004) (0)
- Erratum to: Mass spectrometric analysis of products of metabolic glycan engineering with azido-modification of sialic acids (2015) (0)
- Introduction: The use of animal cell culture (2004) (0)
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