Michael Cashel
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Michael Cashelbiology Degrees
Biology
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Molecular Biology
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Biochemistry
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Biology
Michael Cashel's Degrees
- PhD Biochemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is Michael Cashel Influential?
(Suggest an Edit or Addition)Michael Cashel's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- (p)ppGpp: still magical? (2008) (1058)
- Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations. (1991) (724)
- Two Compounds implicated in the Function of the RC Gene of Escherichia coli (1969) (629)
- Synthesis of the stationary-phase sigma factor sigma s is positively regulated by ppGpp (1993) (474)
- The control of ribonucleic acid synthesis in Escherichia coli. IV. Relevance of unusual phosphorylated compounds from amino acid-starved stringent strains. (1969) (381)
- An improved method for thin-layer chromatography of nucleotide mixtures containing 32P-labelled orthophosphate. (1969) (294)
- Regulation of bacterial ppGpp and pppGpp. (1975) (294)
- Conformational Antagonism between Opposing Active Sites in a Bifunctional RelA/SpoT Homolog Modulates (p)ppGpp Metabolism during the Stringent Response (2004) (286)
- On the regulation of guanosine tetraphosphate levels in stringent and relaxed strains of Escherichia coli. (1971) (248)
- Guanosine Tetra- and Pentaphosphate Promote Accumulation of Inorganic Polyphosphate in Escherichia coli * (1997) (243)
- The control of ribonucleic acid synthesis in Escherichia coli. V. Characterization of a nucleotide associated with the stringent response. (1969) (238)
- ppGpp is the major source of growth rate control in E. coli. (2011) (213)
- Iron limitation induces SpoT‐dependent accumulation of ppGpp in Escherichia coli (2005) (212)
- Overexpression of the relA gene in Escherichia coli. (1991) (210)
- Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in Escherichia coli. (1993) (195)
- DksA Affects ppGpp Induction of RpoS at a Translational Level (2002) (192)
- Differential regulation by ppGpp versus pppGpp in Escherichia coli (2013) (186)
- Mutational analysis of the Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation (1996) (185)
- Differential stringent control of the tandem E. coli ribosomal RNA promoters from the rrnA operon expressed in vivo in multicopy plasmids (1983) (181)
- Intramolecular Regulation of the Opposing (p)ppGpp Catalytic Activities of RelSeq, the Rel/Spo Enzyme from Streptococcus equisimilis (2002) (176)
- Circuitry linking the Csr and stringent response global regulatory systems (2011) (169)
- Function of a relaxed-like state following temperature downshifts in Escherichia coli (1992) (140)
- The nucleotide sequence and characterization of the relA gene of Escherichia coli. (1988) (126)
- Characterization of the relA1 mutation and a comparison of relA1 with new relA null alleles in Escherichia coli. (1989) (126)
- Functional analysis of a relA/spoT gene homolog from Streptococcus equisimilis (1996) (121)
- The mechanism of amino acid control of guanylate and adenylate biosynthesis. (1971) (117)
- Changes in conserved region 3 of Escherichia coli sigma 70 mediate ppGpp-dependent functions in vivo. (1995) (103)
- Characterization of the spoT gene of Escherichia coli. (1989) (102)
- ppGpp couples transcription to DNA repair in E. coli (2016) (101)
- Basal ppGpp level adjustment shown by new spoT mutants affect steady state growth rates and rrnA ribosomal promoter regulation in Escherichia coli (1988) (100)
- The stringent response in Escherichia coli and Salmonella typhimurium (1987) (89)
- Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected]. (2004) (84)
- Selective fluorescent chemosensor for the bacterial alarmone (p)ppGpp. (2008) (84)
- Effects of rifampicin resistant rpoB mutations on antitermination and interaction with nusA in Escherichia coli. (1988) (83)
- Control of RNA synthesis in Escherichia coli. I. Amino acid dependence of the synthesis of the substrates of RNA polymerase. (1968) (81)
- Mutations in the spoT gene of Salmonella typhimurium: effects on his operon expression (1985) (80)
- From (p)ppGpp to (pp)pGpp: Characterization of Regulatory Effects of pGpp Synthesized by the Small Alarmone Synthetase of Enterococcus faecalis (2015) (77)
- THE DEVELOPMENTAL SIGNIFICANCE OF ALANINE DEHYDROGENASE IN BACILLUS SUBTILIS. (1964) (77)
- Effects of Guanosine Tetraphosphate, Guanosine Pentaphosphate, and β-γ Methylenyl-Guanosine Pentaphosphate on Gene Expression of Escherichia coli In Vitro (1974) (76)
- Antagonistic Regulation of Escherichia coli Ribosomal RNA rrnB P1 Promoter Activity by GreA and DksA* (2006) (75)
- The omega subunit of Escherichia coli K-12 RNA polymerase is not required for stringent RNA control in vivo (1991) (74)
- Allosteric effector ppGpp potentiates the inhibition of transcript initiation by DksA (2017) (74)
- The in vitro Synthesis of Ribosomal RNA (1970) (70)
- Isolation of RNA polymerase suppressors of a (p)ppGpp deficiency. (2003) (70)
- Synthesis of the Stationary-Phase Sigma Factor us Is Positively Regulated by ppGpp (68)
- Preparation of guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) from Escherichia coli ribosomes. (1974) (66)
- Separation of Two Functional Roles of l-Alanine in the Initiation of Bacillus subtilis Spore Germination (1967) (65)
- Effects of guanosine tetraphosphate on cell-free synthesis of Escherichia coli ribosomal RNA and other gene products. (1975) (65)
- Functional interrelationship between two tandem E. coli ribosomal RNA promoters (1983) (64)
- Carbon starvation and growth rate-dependent regulation of the Escherichia coli ribosomal RNA promoters: differential control of dual promoters. (1983) (63)
- Protein sequences encoded by the relA and the spoT genes of Escherichia coli are interrelated. (1989) (63)
- Effects on Growth by Changes of the Balance between GreA, GreB, and DksA Suggest Mutual Competition and Functional Redundancy in Escherichia coli (2011) (61)
- The regulation of purine utilization in bacteria. V. Inhibition of purine phosphoribosyltransferase activities and purine uptake in isolated membrane vesicles by guanosine tetraphosphate. (1972) (60)
- Inhibition of RNA Polymerase by ppGpp, a Nucleotide Accumulated during the Stringent Response to Amino Acid Starvation in E. coli (1970) (59)
- Mecillinam resistance in Escherichia coli is conferred by loss of a second activity of the AroK protein (1996) (55)
- The interaction of guanosine 5'-diphosphate, 2' (3')-diphosphate with the bacterial elongation factor Tu. (1973) (52)
- Cellular localization of the Escherichia coli SpoT protein (1995) (52)
- rhlB, a new Escherichia coli K-12 gene with an RNA helicase-like protein sequence motif, one of at least five such possible genes in a prokaryote. (1991) (50)
- In vitro transcripts from the rrn B ribosomal RNA cistron originate from two tandem promoters (1979) (49)
- TraR, a Homolog of a RNAP Secondary Channel Interactor, Modulates Transcription (2009) (48)
- Cellular Regulation of Guanosine Tetraphosphate and Guanosine Pentaphosphate (1974) (47)
- Cell-free coupled transcription-translation system for investigation of linear DNA segments. (1980) (47)
- Excretion of alkaline phosphatase of Bacillus subtilis. (1964) (45)
- CROSSLINKING OF DEOXYRIBONUCLEIC ACID BY EXPOSURE TO LOW PH. (1964) (44)
- Effectors of the Stringent Response Target the Active Site ofEscherichia coli Adenylosuccinate Synthetase* (1999) (42)
- Guanylate kinase of Escherichia coli K-12. (1993) (42)
- On the mechanism of amino acid control of ribonucleic acid biosynthesis. (1967) (40)
- Conserved Region 3 of Escherichia coli σ70 Is Implicated in the Process of Abortive Transcription* (1996) (37)
- Selected amplification of the cell division genes ftsQ-ftsA-ftsZ in Escherichia coli. (2000) (37)
- Role of guanine nucleotides in protein synthesis. Elongation factor G and guanosine 5'-triphosphate,3'-diphosphate. (1973) (35)
- Changes in Conserved Region 3 of Escherichia coliς70 Reduce Abortive Transcription and Enhance Promoter Escape* (2003) (33)
- Decryptification of RNA polymerase in whole cells of Escherichia coli. (1967) (32)
- The Absence of (p)ppGpp Renders Initiation of Escherichia coli Chromosomal DNA Synthesis Independent of Growth Rates (2020) (29)
- Synthetic growth phenotypes of Escherichia coli lacking ppGpp and transketolase A (tktA) are due to ppGpp‐mediated transcriptional regulation of tktB (2008) (26)
- Possible Roles for Basal Levels of (p)ppGpp: Growth Efficiency Vs. Surviving Stress (2020) (25)
- The nucleotide sequence of recG, the distal spo operon gene in Escherichia coli K-12. (1992) (24)
- Methylobacterium extorquens RSH Enzyme Synthesizes (p)ppGpp and pppApp in vitro and in vivo, and Leads to Discovery of pppApp Synthesis in Escherichia coli (2019) (23)
- Guanine nucleotides in protein synthesis. Utilization of pppGpp and dGTP by initiation factor 2 and elongation factor Tu. (1974) (21)
- Contributions of SpoT Hydrolase, SpoT Synthetase, and RelA Synthetase to Carbon Source Diauxic Growth Transitions in Escherichia coli (2018) (18)
- Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro. (2018) (18)
- Regulation of RNA synthesis in Escherichia coli. III. Degradation of guanosine 5'-diphosphate 3'-diphosphate in cold-shocked cells. (1975) (18)
- Imprecise transcription termination within Escherichia coli greA leader gives rise to an array of short transcripts, GraL (2009) (18)
- Characterization of the Escherichia coli K12 gltS glutamate permease gene (1991) (17)
- Guanosine tetraphosphate (ppGpp)-mediated inhibition of the activity of the bacteriophage λp R promoter in Escherichia coli (1998) (17)
- ColE1 cloning of a ribosomal RNA promoter region from lambdarifd18 by selection for lambda integration and excision functions. (1977) (16)
- Polymerase chain reaction (PCR) amplification with a single specific primer. (1990) (14)
- A Mutation within the β Subunit of Escherichia coli RNA Polymerase Impairs Transcription from Bacteriophage T4 Middle Promoters (2010) (14)
- Conserved region 3 of Escherichia coli final sigma70 is implicated in the process of abortive transcription. (1996) (13)
- Stable RNA-DNA-RNA polymerase complexes can accompany formation of a single phosphodiester bond. (1980) (13)
- GUANOSINE 3′,5′-BISPYROPHOSPHATE IS A DISPENSABLE METABOLITE (1979) (12)
- Guanosine 5'-diphosphate, 3'-diphosphate: assignment of structure by 13C nuclear magnetic resonance spectroscopy. (1973) (11)
- Growth at best and worst of times (2018) (11)
- Gene expression of an Escherichia coli ribosomal RNA promoter fused to structural genes of the galactose operon. (1979) (10)
- Regulation of RNA synthesis in Escherichia coli. I. Characterization of cells subjected to simultaneous temperature and osmotic shock. (1973) (9)
- Puzzling conformational changes affecting proteins binding to the RNA polymerase (2018) (8)
- The E. coli Global Regulator DksA Reduces Transcription during T4 Infection (2018) (8)
- Functional Analysis of arelA/spoTGene Homolog fromStreptococcus equisimilis (1996) (6)
- A RADIOIMMUNOASSAY FOR ppGpp (1979) (5)
- Mutational analysis of Escherichia coli GreA protein reveals new functional activity independent of antipause and lethal when overexpressed (2020) (5)
- Preferential Cellular Accumulation of ppGpp or pppGpp in Escherichia Coli (2016) (4)
- Using Microtiter Dish Radiolabeling for Multiple In Vivo Measurements Of Escherichia coli (p)ppGpp Followed by Thin Layer Chromatography. (2019) (4)
- Estimates of RelSeq, Mesh1, and SAHMex Hydrolysis of (p)ppGpp and (p)ppApp by Thin Layer Chromatography and NADP/NADH Coupled Assays (2020) (4)
- Effects of guanosine tetraphosphate, guanosine pentaphosphate, and beta-gamma methylenyl-guanosine pentaphosphate on gene expression of Escherichia coli in vitro. (1974) (3)
- Preparation of [β-32P]ribonucleoside-5′-triphosphates using permeable cells of Escherichia coli (1973) (3)
- Regulation of RNA synthesis in Escherichia coli. II. Polynucleotide phosphorylase activity in cold-shocked cells☆ (1974) (3)
- Expression of autophosphorylating protein kinase 500 in normal and neoplastic rat cells. (1985) (2)
- The secondary messenger ppGpp interferes with cAMP-CRP regulon by promoting CRP acetylation in Escherichia coli (2021) (2)
- Virus–Host Interaction Gets Curiouser and Curiouser. PART I: Phage P1vir Enhanced Development in an E. coli DksA-Deficient Cell (2021) (2)
- Regulation of RNA in Escherichia coli. II. Polynucleotide phosphorylase activity in cold-shocked cells. (1974) (1)
- GLUCOSE-6-PHOSPHATE DEHYDROGENASE SELECTION BY METHYLENE BLUE IN HUMAN CELL CULTURES. (1965) (1)
- expression. typhimurium: effects on his operon Mutations in the spoT gene of Salmonella (2014) (0)
- The Nucleotide Sequence and Characterization of the reZA Gene of Escherichia coli * (2001) (0)
- Editorial: (p)ppGpp and Its Homologs: Enzymatic and Mechanistic Diversity Among the Microbes (2021) (0)
- Crystal structure of the bifunctional catalytic fragment of RelSeq, the RelA/SpoT homolog from Streptococcus equisimilis. (2004) (0)
- Brief Reports on All Topics (1981) (0)
- Preparation of (beta-32P)ribonucleoside-5'-triposphates using permeable cells of Escherichia coli. (1973) (0)
- The Effect of Guanosine Tetraphosphate (ppGpp), and P-Y-Methylene Guanosine Pentaphosphate (ppGppp) on E. coli Gene Expression (1974) (0)
- STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI COMPLEXED WITH A STRINGENT EFFECTOR, PPG2':3'P (1999) (0)
- Regulatory Features Deduced from the Structure of the Catalytic Domain of a Streptococcal Enzyme that Synthesizes and Degrades (p)ppGpp (2004) (0)
- Effects of Guanosine Tetraphosphate, Guanosine Pentaphosphate, and 3--y Methylenyl-Guanosine Pentaphosphate on Gene Expression of (2016) (0)
- Acknowledgment to reviewers (2018) (0)
- Regulation of Bacterial Genes (1973) (0)
- Stringent Mutant/Stringent Response (2013) (0)
- Growth at best and worst of times (2018) (0)
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