Michael Dexter | Academic Influence

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Michael Dexter

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Philosophy

Michael Dexter's Degrees

Masters Medicine University of Oxford

Why Is Michael Dexter Influential?

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According to Wikipedia, Michael Dexter FRS is a British haematologist and director of the Wellcome Trust, from 1998 to 2003. Education Dexter was inspired to take A levels at night school and went on study physiology and zoology at the University of Salford. After graduating, he continued in academia and received a PhD from the University of Manchester in 1974 for research into Leukemia. Dexter also received a Doctor of Science degree from the University of Salford in 1982.

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Michael Dexter's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Conditions controlling the proliferation of haemopoietic stem cells in vitro (1977) (2169)
Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis (1990) (990)
Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis (1988) (811)
Growth factors in development, transformation, and tumorigenesis (1991) (700)
Growth of factor-dependent hemopoietic precursor cell lines (1980) (697)
Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. (1987) (520)
Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors (1993) (378)
Stromal cell associated haemopoiesis (1982) (343)
The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo. (1989) (331)
Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. (1990) (310)
Self-renewal and differentiation of interleukin-3-dependent multipotent stem cells are modulated by stromal cells and serum factors. (1986) (277)
The use of granulocyte colony-stimulating factor to increase the intensity of treatment with doxorubicin in patients with advanced breast and ovarian cancer. (1989) (250)
Do stem cells play dice? (1998) (244)
Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants (1998) (233)
Growth of human umbilical-cord blood in longterm haemopoietic cultures (1992) (217)
Effect of Campath-1H antibody on human hematopoietic progenitors in vitro. (1993) (216)
Anaemia in bovine African trypanosomiasis. A review. (1988) (197)
Growth and differentiation in the hemopoietic system. (1987) (193)
Proliferation of Haemopoietic Stem Cells in Vitro (1974) (190)
Cellular interrelationships during in vitro granulopoiesis. (1976) (187)
Myeloid cell kinetics in mice treated with recombinant interleukin-3, granulocyte colony-stimulating factor (CSF), or granulocyte-macrophage CSF in vivo. (1991) (184)
The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor. (1991) (184)
Direct comparison by limiting dilution analysis of long-term culture-initiating cells in human bone marrow, umbilical cord blood, and blood stem cells. (1994) (183)
Differentiation and proliferation of hemopoietic cells in culture. (1976) (177)
A comparison of hematopoiesis in normal and splenectomized mice treated with granulocyte colony-stimulating factor. (1990) (160)
Stimulation of differentiation and proliferation of haemopoietic cells in vitro (1973) (155)
Characterization and partial purification of a haemopoietic cell growth factor in WEHI-3 cell conditioned medium. (1983) (153)
Identification of two binding sites for wheat-germ agglutinin on polylactosamine-type oligosaccharides. (1985) (152)
Transplantation potential of hematopoietic cells released into the circulation during routine chemotherapy for non-Hodgkin's lymphoma. (1993) (152)
Regulation of haemopoietic stem cell proliferation in long term bone marrow cultures. (1977) (151)
Maintenance of hemopoietic stem cells and production of differentiated progeny in allogeneic and semiallogeneic bone marrow chimeras in vitro (1977) (150)
Regulation of haemopoiesis in long-term bone marrow cultures. IV. Glycosaminoglycan synthesis and the stimulation of haemopoiesis by beta- D-xylosides (1983) (136)
The essential cells of the hemopoietic microenvironment. (1984) (132)
Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo. (1992) (120)
The role of hemopoietic growth factors in self-renewal and differentiation of IL-3-dependent multipotential stem cells. (1990) (120)
Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein. (1999) (119)
The regulation of hemopoiesis in long-term bone marrow cultures. II. Stimulation and inhibition of stem cell proliferation. (1980) (110)
Long-term marrow culture: an overview of techniques and experience. (1984) (110)
RECONSTITUTION OF HAEMOPOIETIC SYSTEM WITH AUTOLOGOUS MARROW TAKEN DURING RELAPSE OF ACUTE MYELOBLASTIC LEUKAEMIA AND GROWN IN LONG-TERM CULTURE (1986) (109)
Metabolically inactive 3T3 cells can substitute for marrow stromal cells to promote the proliferation and development of multipotent haemopoietic stem cells (1987) (105)
In vitro assessment of marrow ‘stem cell’and stromal cell function in aplastic anaemia (1991) (101)
Myeloid haemopoietic growth factors. (1989) (95)
Isolation and characterisation of a bipotential haematopoietic cell line (1979) (94)
Production of monocyte/macrophage colony‐stimulating factor by preadipocyte cell lines derived from murine marrow stroma (1982) (90)
Role of the cellular matrix in haemopoiesis. I. Synthesis of glycosaminoglycans by mouse bone marrow cell cultures. (1983) (90)
Effects of recombinant human granulocyte colony-stimulating factor (CSF), human granulocyte macrophage-CSF, and gibbon interleukin-3 on hematopoiesis in human long-term bone marrow culture. (1990) (90)
Ultrastructural aspects of erythropoietic differentiation in long-term bone marrow culture. (1982) (89)
Continuous in vitro generation of multipotential stem cell clones from src-infected cultures (1984) (88)
The hematopoietic defect in aplastic anemia assessed by long-term marrow culture. (1990) (88)
Effect of haematopoietic cell growth factor on intracellular ATP levels (1983) (88)
Clonal preadipocyte cell lines with different phenotypes derived from murine marrow stroma: Factors influencing growth and Adipogenesis in vitro (1982) (88)
Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation (1991) (87)
Haemopoietic cell growth factor mediates cell survival via its action on glucose transport. (1984) (86)
The role of cells and their products in the regulation of in vitro stem cell proliferation and granulocyte development. (1980) (86)
Haemopoiesis in long-term bone marrow cultures. A review. (1979) (84)
Cell adhesion in the stromal regulation of haemopoiesis. (1992) (84)
The use of bone marrow cells grown in long-term culture for autologous bone marrow transplantation in acute myeloid leukaemia: an update. (1989) (82)
Stromal cells in haemopoiesis. (1990) (81)
Interleukin 3 stimulates proliferation via protein kinase C activation without increasing inositol lipid turnover. (1988) (81)
The hematopoietic defect in aplastic anemia assessed by long-term marrow culture (1990) (80)
Marrow biology and stem cells. (1990) (79)
Production of colony stimulating factor in long‐term bone marrow cultures (1983) (77)
Bone Marrow Culture Studies in Refractory Cytopenia and ‘Smouldering Leukaemia’ (1977) (76)
Molecular and cell biologic aspects of erythropoiesis in long-term bone marrow cultures. (1981) (74)
Erythropoietin-stimulated erythropoiesis in long-term bone marrow culture (1979) (73)
Infection of bone marrow cells in vitro with FLV: Effects on stem cell proliferation, differentiation and leukemogenic capacity (1977) (73)
Multicyclic, dose-intensive chemotherapy supported by sequential reinfusion of hematopoietic progenitors in whole blood. (1995) (72)
The development of a liquid culture system for the growth of human bone marrow. (1980) (72)
Hemopoietic effects of short-term in vivo treatment of mice with various doses of rhG-CSF. (1990) (71)
BB-10010: an active variant of human macrophage inflammatory protein-1 alpha with improved pharmaceutical properties. (1995) (71)
Effect of src infection on long-term marrow cultures: Increased self-renewal of hemopoietic progenitor cells without leukemia (1984) (70)
Growth inhibitory effects of transforming growth factor-beta 1 in vivo. (1991) (68)
Viability of haemopoietic progenitors from whole blood, bone marrow and leukapheresis product: effects of storage media, temperature and time. (1994) (67)
Transforming Growth Factor-β1 Induces Apoptosis Independently of p53 and Selectively Reduces Expression of Bcl-2 in Multipotent Hematopoietic Cells* (2000) (66)
Increased numbers of long-term culture-initiating cells in the apheresis product of patients randomized to receive increasing doses of stem cell factor administered in combination with chemotherapy and a standard dose of granulocyte colony-stimulating factor. (1996) (66)
The role of growth factors in self-renewal and differentiation of haemopoietic stem cells. (1990) (66)
Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line. (1994) (65)
Prolonged hematopoiesis in a primate bone marrow culture system: characteristics of stem cell production and the hematopoietic microenvironment. (1979) (65)
Recombinant human interleukin 4 (IL-4) given as daily subcutaneous injections--a phase I dose toxicity trial. (1992) (63)
Haemopoietic stem cells and the problem of self-renewal. (1984) (63)
Filgrastim (r-metHuG-CSF) in clinical practice (1998) (63)
Identification of a common signal associated with cellular proliferation stimulated by four haemopoietic growth factors in a highly enriched population of granulocyte/macrophage colony‐forming cells. (1989) (62)
Stem cell factor directly stimulates the development of enriched granulocyte-macrophage colony-forming cells and promotes the effects of other colony-stimulating factors. (1992) (62)
Long‐Term Production of Erythroid Precursor Cells (BFU) in Bone Marrow Cultures (1977) (62)
O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow. (1997) (61)
The regulation of haemopoiesis in long‐term bone marrow cultures: I. Role of L‐cell CSF (1980) (60)
Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells (1994) (59)
Inhibitors of Haemopoietic Cell Proliferation?: Specificity of Action Within the Haemopoietic System (1974) (58)
Transfection of murine multi-potent haemopoietic stem cells with an E. coli DNA alkyltransferase gene confers resistance to the toxic effects of alkylating agents. (1988) (58)
The kinetic response of haemopoietic precursor cells, in vivo, to highly purified, recombinant interleukin-3. (1986) (58)
Histochemical and ultrastructural characteristics of a cell line from human bone-marrow stroma. (1981) (56)
Blood cell development: The message in the medium (1984) (56)
An Activated Protein Kinase C α Gives a Differentiation Signal for Hematopoietic Progenitor Cells and Mimicks Macrophage Colony-stimulating Factor–stimulated Signaling Events (1998) (55)
Haemopoietic growth factors. (1986) (55)
"Stem cell" origin of the hematopoietic defect in dyskeratosis congenita. (1992) (54)
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells. (1990) (54)
Loss of immunoreactivity in long-term bone marrow culture (1978) (54)
Regulation of hemopoietic cell growth and development: experimental and clinical studies. (1989) (52)
Erythroid development of the FDCP‐Mix A4 multipotent cell line is governed by the relative concentrations of erythropoietin and interleukin 3 (1995) (51)
In vitro methods in haemopoiesis and lymphopoiesis. (1980) (51)
Haemopoietic cells mobilised into the circulation by lenograstim as alternative to bone marrow for allogeneic transplants (1993) (51)
The capacity of peripheral blood stem cells mobilised with chemotherapy plus G-CSF to repopulate irradiated marrow stroma in vitro is similar to that of bone marrow. (1992) (51)
The response of haemopoietic cells to growth factors: developmental implications of synergistic interactions. (1988) (50)
Biological and structural properties of MIP-1 alpha expressed in yeast. (1992) (50)
Defective ability to self-renew in vitro of highly purified primitive haematopoietic cells (1985) (49)
Influence of interleukin-3 and other growth factors on alpha4beta1 integrin-mediated adhesion and migration of human hematopoietic progenitor cells. (1997) (48)
Phorbol esters activate protein kinase C and glucose transport and can replace the requirement for growth factor in interleukin-3-dependent multipotent stem cells. (1986) (48)
Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. (1988) (47)
Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase (1998) (47)
Total marrow failure induced by pegylated stem-cell factor administered before 5-fluorouracil. (1994) (47)
Influence of growth factors and substrates on differentiation of haemopoietic stem cells. (1993) (46)
Long-term protection of hematopoiesis against the cytotoxic effects of multiple doses of nitrosourea by retrovirus-mediated expression of human O6-alkylguanine-DNA-alkyltransferase. (1996) (45)
Markedly elevated levels of an endogenous sarc protein in a hemopoietic precursor cell line (1981) (44)
Long-term in vitro correction of alpha-L-iduronidase deficiency (Hurler syndrome) in human bone marrow. (1996) (44)
p210 Bcr–Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia (1998) (44)
Randomized comparison of progenitor-cell mobilization using chemotherapy, stem-cell factor, and filgrastim or chemotherapy plus filgrastim alone in patients with ovarian cancer. (1998) (41)
The myelosuppressive effect of recombinant interferon γ in short‐term and long‐term marrow cultures (1986) (38)
Collagen gels as a matrix for haemopoiesis (1981) (38)
Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro (1998) (37)
The engraftment capacity of peripheral blood progenitor cells (PBPC) mobilised with chemotherapy ± G‐CSF (1992) (37)
Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation (2000) (37)
Comparison of haemopoiesis in young and old mice (1986) (37)
The regulation of hemopoietic cell development by the stromal cell environment and diffusible regulatory molecules. (1984) (36)
Effects of long-term in vivo treatment of mice with purified murine recombinant GM-CSF. (1989) (35)
Quantitative development of adherent cell colonies in bone marrow cell culture in vitro. (1979) (34)
Apoptosis in the haemopoietic system. (1994) (33)
Interleukin-3-stimulated haemopoietic stem cell proliferation. Evidence for activation of protein kinase C and Na+/H+ exchange without inositol lipid hydrolysis. (1988) (33)
Cellular interactions between 3T3 cells and interleukin‐3‐dependent multipotent haemopoietic cells: A model system for stromal‐cell‐mediated haemopoiesis (1989) (32)
Long-term bone marrow cultures: their use in autologous marrow transplantation. (1989) (32)
Growth And Differentiation In The Hematopoietic System (1987) (32)
Chemical cross linking subtraction (CCLS): a new method for the generation of subtractive hybridisation probes. (1992) (31)
The biochemistry and biology of the myeloid haemopoietic cell growth factors (1990) (30)
The mouse M-lysozyme gene domain: identification of myeloid and differentiation specific DNasel hypersensitive sites and of a 3'-cis acting regulatory element. (1992) (30)
The effects of TGF beta on haemopoietic cells. (1989) (29)
Stem cell regulation in continuous hematopoietic cell culture. (1978) (29)
Studies on the Mechanisms of Chemical Leukaemogenesis (1974) (29)
Is the marrow stroma transplantable? (1982) (28)
Apoptosis in haemopoietic progenitor cells exposed to extremely low-frequency magnetic fields. (1997) (28)
Long term bone marrow cultures: an ultrastructural review. (1983) (28)
Friend disease in vitro (1981) (27)
CFU-S repopulation after low-dose whole-body radiation. (1982) (27)
Mechanisms of haemopoietic stem cell proliferation control. (1979) (27)
Localisation of granulocyte macrophage colony-stimulating factor in human long-term bone marrow cultures. Biological and immunocytochemical characterisation. (1993) (26)
Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase. (1996) (26)
TRANSPLANTATION OF LONG‐TERM CULTURED BONE MARROW CELLS (1983) (26)
Studies on the self-renewal ability of CFU-S which have been serially transferred in long-term culture or in vivo. (1985) (26)
Development of stromal cell colonies in bone marrow cell culture. (1978) (26)
Interleukin‐3‐dependent hematopoietic stem cell lines capable of osteoclast formation in vitro (1991) (26)
Stimulation of hexose uptake by haemopoietic cell growth factor occurs in WEHI‐3B myelomonocytic leukaemia cells: A possible mechanism for loss of growth control (1985) (24)
Investigation of the molecular mechanisms underlying growth factor synergy: the role of ERK 2 activation in synergy. (1998) (24)
EFFECT OF HYDROCORTISONE ON LONG‐TERM HUMAN MARROW CULTURES (1981) (24)
New strategies for the treatment of chronic myeloid leukemia. (1994) (24)
Restriction of expression of an integrated recombinant retrovirus in primary but not immortalized murine hematopoietic stem cells. (1988) (23)
A Randomized Phase-II Study of BB-10010 (Macrophage Inflammatory Protein- 1) in Patients With Advanced Breast Cancer Receiving 5-Fluorouracil, Adriamycin, and Cyclophosphamide Chemotherapy (1998) (23)
Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha (1998) (22)
Dose-escalating induction chemotherapy supported by lenograstim preceding high-dose consolidation chemotherapy for advanced breast cancer. Selection of the most acceptable regimen to induce maximal tumor response and investigation of the optimal time to collect peripheral blood progenitor cells for (1994) (22)
Development of multipotential haemopoietic stem cells to neutrophils is associated with increased expression of receptors for granulocyte macrophage colony-stimulating factor: altered biological responses to GM-CSF during development. (1991) (22)
IL-4 promotes macrophage development by rapidly stimulating lineage restriction of bipotent granulocyte-macrophage colony-forming cells. (1995) (22)
Expression and downregulation of cytotoxic cell protease 1 or Granzyme 'B' transcripts during myeloid differentiation of interleukin-3-dependent murine stem cell lines (1992) (22)
What are mast cells for? (1981) (22)
Haemopoietic cell growth factor and glucose transport. Its role in cell survival and the relevance of this in normal haemopoiesis and leukaemia. (1984) (22)
The effect of prostaglandin E1 on hemopoiesis in long-term bone marrow cultures. (1980) (21)
Metabolic properties of a homogeneous proteoglycan of a haemopoietic stem cell line, FDCP-mix. (1989) (20)
Uptake of α-(L)-iduronidase produced by retrovirally transduced fibroblasts into neuronal and glial cells in vitro (1997) (20)
Clinical use of haematopoietic growth factors. (1989) (20)
Purification of haemopoietic stem cells--the end of the road? (1988) (20)
Studies on the in vivo production of a lymphokine activity, interleukin 3 (IL-3) elaborated by lymphocytes and a myeloid leukaemic line in vitro and the fate of IL-3 dependent cell lines. (1983) (20)
Clinical effects of human macrophage inflammatory protein-1 alpha MIP-1 alpha (LD78) administration to humans: a phase I study in cancer patients and normal healthy volunteers with the genetically engineered variant, BB-10010. (1998) (19)
Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells. (1997) (19)
The regulation of growth and development of normal and leukaemic cells (1983) (19)
Human cord blood: a source of transplantable stem cells? (1992) (19)
Characterisation of monoclonal antibodies which specifically recognise the human erythrocyte glucose transport protein. (1985) (18)
Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line. (1998) (18)
Characterization of malignant cell populations in MNU-induced leukaemia of mice. (1979) (18)
Haemopoietic stem cell development to neutrophils is associated with subcellular redistribution and differential expression of protein kinase C subspecies. (1993) (17)
Perturbed hemopoiesis and the generation of multipotential stem cell clones in src-infected bone marrow cultures is an indirect or transient effect of the oncogene (1986) (17)
Clonal hematopoiesis as defined by polymorphic X-linked loci occurs infrequently in aplastic anemia. (1995) (17)
bcl‐2 delay of alkylating agent‐induced apoptotic death in a murine hemopoietic stem cell line (1994) (17)
Clinical use of growth factors. (1989) (16)
Colony-stimulating factors in the clinic. (1992) (16)
An antagonist to platelet activating factor counteract the tumouricidal action of alkyle lysopholipids (1989) (16)
Growth and development of haemopoietic cells: a deterministic process? (1989) (16)
Stem cells in normal growth and disease. (1987) (15)
The Role of Stromal Cells and Growth Factors in Haemopoiesis and Modulation of their Effects by the src Oncogene (1985) (15)
A randomized phase-II study of BB-10010 (macrophage inflammatory protein- 1alpha) in patients with advanced breast cancer receiving 5-fluorouracil, adriamycin, and cyclophosphamide chemotherapy. (1998) (15)
Growth and development in the haemopoietic system: the role of lymphokines and their possible therapeutic potential in disease and malignancy. (1986) (15)
Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells (1993) (15)
The use of cultured bone marrow cells in autologous transplantation. (1990) (14)
Characterisation of the differential response of normal and CML haemopoietic progenitor cells to macrophage inflammatory protein-1α (1999) (14)
Malignant myelomonocytic cells after in vitro infection of marrow cells with Friend leukaemia virus. (1980) (14)
Synergistic interactions in haemopoiesis: biological implications and clinical use. (1993) (14)
Biological consequences of p160v-abl protein tyrosine kinase activity in a primitive, multipotent haemopoietic cell line. (1994) (14)
Identification of a Serpin Specifically Expressed in Multipotent and Bipotent Hematopoietic Progenitor Cells and in Activated T Cells (1997) (13)
A minimal serpin promoter with high activity in haematopoietic progenitors and activated T cells. (2001) (13)
The biology of long-term bone marrow cultures and its application to bone marrow transplantation. (1991) (13)
Chemoprotection of normal tissues by transfer of drug resistance genes (1996) (13)
Growth without inflation (1990) (13)
Interferon-gamma stimulates the survival and influences the development of bipotential granulocyte-macrophage colony-forming cells. (1991) (13)
Cell interactions in vitro. (1979) (12)
Long-term hematopoietic damage: concepts, approaches, and results relevant to the study of environmental toxins. (1989) (12)
How do stem cells decide what to do? (1992) (12)
Erythropoietin and myeloid colony stimulating factors. (1992) (12)
A comparative morphometric study on the ultrastructure of adherent cells in long-term bone marrow culture from normal and congenitally anemic mice. (1989) (12)
Mobilisation kinetics of primitive haemopoietic cells following G-CSF with or without chemotherapy for advanced breast cancer. (1996) (11)
The regulation of hemopoiesis in long-term bone marrow cultures. III. The role of burst forming activity. (1982) (11)
The role of growth factors in haemopoiesis (1985) (11)
Self-renewing haemopoietic progenitor cells and the factors controlling proliferation and differentiation. (1981) (11)
Growth and differentiation in the haemopoietic system. (1991) (11)
Serum-free culture of enriched murine haemopoietic stem cells. I: Effect of haemopoietic growth factors on proliferation. (1991) (11)
Congenital and induced defects in haemopoietic environments, stem cell proliferation and differentiation. (1979) (11)
Infection of mouse bone marrow cells with Abelson murine leukemia virus and establishment of producer cell lines. (1979) (11)
Autografting in Philadelphia (Ph)+ chronic myeloid leukaemia using cultured marrow: an update of a pilot study (1997) (10)
Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells. (1993) (10)
Macrophage inflammatory protein-1 alpha mediated growth inhibition in a haemopoietic stem cell line is associated with inositol 1,4,5 triphosphate generation. (1995) (10)
Tissue culture — use or abuse? (1983) (10)
A reliable approach for sequencing clone-specific CDRIII regions in B-cell lymphoma. (1994) (10)
Biological effects of retroviral transfection of the murine interleukin-3 gene into FDCP-Mix cells. (1989) (10)
Culturing primitive hemopoietic cells. Long-term mouse marrow cultures and the establishment of factor-dependent (FDCP-Mix) hemopoietic cell lines. (1997) (10)
Exposure to extremely low frequency magnetic fields has no effect on growth rate or clonogenic potential of multipotential haemopoietic progenitor cells. (1996) (10)
Evaluation of cytogenetic conversion to Ph− haemopoiesis in long‐term bone marrow culture for patients with chronic myeloid leukaemia on conventional hydroxyurea therapy, on pulse high‐dose hydroxyurea and on interferon‐alpha (1996) (9)
Proliferation of hemopoietic stem cells and development of potentially leukemic cells in vitro. (1976) (9)
Evaluation of a mouse Y chromosome probe for assessing marrow transplantation. (1989) (9)
The role of haemopoietic cell growth factor (interleukin 3) in the development of haemopoietic cells. (1985) (9)
Which are the hematopoietic stem cells? [or: don't debunk the history!]. (1995) (9)
Combinations of colony-stimulating factors promote enhanced proliferative potential in enriched granulocyte-macrophage colony-forming cells. (1994) (9)
Directional random oligonucleotide primed (DROP) global amplification of cDNA: its application to subtractive cDNA cloning. (1996) (9)
Expression of Epstein-Barr virus latent membrane protein influences self-renewal and differentiation in a multipotential murine haemopoietic 'stem cell' line. (1993) (9)
Growth factors involved in haemopoiesis. (1987) (8)
Studies on the self-renewal and differentiation of stem cells in long term marrow cultures. (1985) (8)
Towards gene therapy of Hurler syndrome. (1997) (8)
Inhibitors of cholera toxin-induced adenosine diphosphate ribosylation of membrane-associated proteins block stem cell differentiation. (1985) (8)
Isolation and characterization of a bipotential haema- topoietic cell line. (1979) (8)
Terminal deoxynucleotidyl transferase in a case of PH positive infant chronic myelogenous leukamia. (1976) (8)
Growth and differentiation of hematopoietic stem cells. (1988) (8)
Factors controlling the proliferation of haemopoietic stem cells in vitro. (1978) (8)
Long-term bone marrow cultures. (1984) (8)
The role of colony stimulating factors, interleukin 1 and stromal extracellular matrix in the regulation of stem cell development. (1988) (8)
Growth of factor-dependent haematopoietic cell lines (1981) (8)
Haemopoietic growth factors: their role in acute myeloblastic leukaemia. (1989) (7)
The Relevance of Protein Kinase C Activation, Glucose Transport and ATP Generation in the Response of Haemopoietic Cells to Growth Factors (1986) (7)
The use of cultured bone marrow cells for autologous transplantation in patients with acute myeloblastic leukemia. (1987) (7)
Long-term marrow cultures in the analysis of viral leukaemogenesis. (1984) (7)
Long-term marrow cultures: in vitro purging of leukaemic cells. (1991) (7)
Self-renewal of haemopoietic stem cells: the roles of the environment, of growth factors and of the src oncogene. (1985) (7)
Mutants of a multipotent hematopoietic cell line blocked in GM-CSF-induced differentiation are leukemogenic in vivo. (1994) (7)
The regulation of haemopoietic stem cells, progenitor cells and macrophage development. (1983) (6)
Studies on the In Vitro Culture of Murine Fetal Thymus: Effect of Factors Promoting Epithelial Growth * (1981) (6)
Selective inhibition of primitive hemopoietic colony-forming cells by an extract from normal marrow: comparison with transforming growth factor-beta. (1991) (6)
A study of ovarian cancer patients treated with dose-intensive chemotherapy supported with peripheral blood progenitor cells mobilised by filgrastim and cyclophosphamide. (1996) (6)
The biological aging of bone marrow (1993) (6)
Comparative assessment and analysis of peripheral blood and bone marrow The International Journal of Cell Cloning (1992) (6)
Insertional mutagenesis as a route to identifying genes involved in self renewal of haemopoietic stem cells. (2000) (6)
Growth factors and the molecular control of haematopoiesis (2005) (6)
Relationship of haemopoietic growth factor to lymphocytes and interleukin 3: a short review. (1983) (6)
Growth factors in differentiation and development (1990) (5)
Culturing Primitive Hemopoietic Cells : Long-Term Mouse Marrow Cultures and the Establishment of Factor-Dependent (FDCP-Mix) Hemopoietic Cell Lines. (1990) (5)
Salaries of Research Workers (1975) (5)
The Mode of Action of Interleukin 3 in Promoting Survival, Proliferation, and Differentiation of Hemopoietic Progenitor Cells (1988) (5)
Reply to letter by Weissman et al. (1989) (5)
Introduction to the haemopoietic system. (1990) (5)
Hematopoietic lineages in health and disease (1997) (5)
Expression and downregulation of cytotoxic cell protease 1 or Granzyme 'B' transcripts during myeloid differentiation of interleukin-3-dependent murine stem cell lines. (1992) (5)
Production of a multipotential cell (CFU‐S) proliferation inhibitor by various populations of mouse and human macrophages (1988) (5)
Long-Term Bone Marrow Culture in Autologous Transplantation: An In Vitro Biological System for Purging Leukemic Cells (1988) (5)
An antagonist to platelet activating factor counteracts the tumoricidal action of alkyl lysophospholipids. (1989) (5)
Binding of Growth Factors to Heparan Sulphate: Implications for the Regulation of Hemopoiesis by Bone Marrow Stromal Cells (1989) (5)
Production of Erythroid Precursor Cells (BFU) In Vitro (1978) (5)
Modification of the proliferative and differentiation capacity of stem cells following treatment with chemical and viral leukemogens. (1979) (5)
Altered stem cell (CFU-S) function following infection of hematopoietic cells with a virus carrying V-src (1986) (4)
Serum-free culture of enriched murine haemopoietic stem cells. II: Effects of growth factors and haemin on development. (1991) (4)
Lymphoid antigens on non-lymphoid factor-dependent haemopoietic cell lines. (1982) (4)
Clinical application of hematopoietic growth factors. (1990) (4)
Macrophage inflammatory protein 1alpha attenuates the toxic effects of temozolomide in human bone marrow granulocyte-macrophage colony-forming cells. (2000) (4)
Platelet activating factor antagonist L-652,731 inhibits thymidine transport. (1989) (4)
An open phase I study to assess the biological effects of a continuous intravenous infusion of Interleukin-3 followed by Granulocyte Macrophage-Colony Stimulating Factor. (1996) (4)
Developmentally-related changes in surface membrane glycopeptides of murine haemopoietic cells. (1987) (4)
Haemopoietic microenvironments in vitro--which cells are involved? (1984) (3)
Upstream elements bestow T-cell and haemopoietic progenitor-specific activity on the granzyme B promoter. (1999) (3)
Differentiation and gene regulation. From the regulation of growth, differentiation, and death in vitro to the onset and maintenance of differentiation in vivo. (1997) (3)
- Benzylguanine Potentiates the In Vivo Toxicity and Clastogenicity of Temozolomide and BCNU in Mouse Bone Marrow (1997) (3)
Purification of a nucleoside-transporter using monoclonal antibody (1986) (3)
Bone marrow stroma: its role in haematopoiesis (1994) (2)
Role of interleukin-3 in the regulation of intracellular K+ homeostasis in cultured murine haemopoietic cells. (1995) (2)
Stimulation of platelet production in vivo by a factor in cell culture conditioned medium. (1978) (2)
Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells – implications for chemoprotective gene therapy (1999) (2)
Haemopoietic growth factors: their role in cell development and their clinical use (1989) (2)
10 Haemopoietic growth factors and haematological malignancies (1990) (2)
Cancer chemotherapy: in vitro test (1978) (2)
Granulocyte colony stimulating factor: from laboratory bench to clinical use. (1994) (2)
The role of growth factors in haemopoietic development: Clinical and biological implications (1989) (2)
Characterization of myelomonocytic leukemia cells induced by in vitro infection of bone marrow with FLV. (1979) (2)
Cell lineages in haemopoiesis: comments on their regulation. (1990) (2)
Transplantation of cultured hemopoietic stem cells. (1980) (1)
Increased Numbers of Progenitor Cells in the Apheresis Product of Patients Randomised to Receive Increasing Doses of Stem Cell Factor (r-metHuSCF) Administered in Combination with Chemotherapy and a Standard Dose of Filgrastim (r-metHuG-CSF) (1998) (1)
Haemopoietic Cell Growth Factor: Characterisation and Mode of Action (1985) (1)
Philadelphia-chromosome-positive childhood chronic myeloid leukaemia. (1978) (1)
Agents which modify mono-ADP ribosylation can influence the differentiation of hemopoietic cells. (1988) (1)
Cell lineage specificity of chromatin configuration and gene expression in haemopoietic progenitor cells. (1989) (1)
Recombinant human megakaryocyte growth and development factor (MGDF) increases the numbers of megakaryocyte progenitor cells to normal values in long-term bone marrow cultures of patients with AML in first remission (1998) (1)
Recent Results in Cancer Research: In vitro Cloning of Normal and Leukaemic Cells (1978) (1)
Biology of Haematopoietic Cell Growth Factors (1996) (1)
[The effect of GM-CSF/IL-3 on the grafting efficiency of CD34+ hemopoietic progenitor cells from umbilical cord blood]. (1995) (1)
Granulocyte colony-stimulating factor (1998) (1)
Altered stem cell (CFU-S) function following infection of hematopoietic cells with a virus carrying V-src. (1986) (1)
MOLECULAR GENETICS AND CELL CULTURE ASSAYS FOR HELPER-INDEPENDENT AND REPLICATION-DEFECTIVE COMPONENTS OF THE FRIEND VIRUS COMPLEX (1980) (1)
Growth factors. Growth without inflation. (1990) (1)
Recombinant humaninterleukin 4(IL-4) given asdaily subcutaneous injections aphase Idosetoxicity trial (1992) (0)
Partial characterization of murine haematopoietic cell growth factor mRNA. (1985) (0)
granulocyte-macrophage CSF in vivo granulocyte colony-stimulating factor (CSF), or Myeloid cell kinetics in mice treated with recombinant interleukin-3, (2011) (0)
Interleukin-4 receptor expression in chronic lymphocytic-leukemia (1993) (0)
primary but not immortalized murine hematopoietic stem cells Restriction of expression of an integrated recombinant retrovirus in (2011) (0)
The peak numbers of colony-forming cells and of cd34+ cells released into peripheral-blood after g-csf (lenograstim) with or without chemotherapy may not be correlated with the capacity of harvested blood-cells to repopulate bone-marrow. (1994) (0)
Stem cell factor (r-metHuSCF) in combination with filgrastim (r-metHuG-CSF) enhances peripheral blood progenitor cell (PBPC) mobilisation following chemotherapy: A randomised study (1997) (0)
The development of hemopoietic cells in response to stromal cells or growth factors is modified by agents that influence ADP-ribosylation. (1988) (0)
BASIC N EUROSCIENCES, G ENETICS A ND I MMUNOLOGY - R EVIEW A RTICLE (2011) (0)
RAPID COMMUNICATION BB-10010: An Active Variant of Human Macrophage Inflammatory Protein-la With Improved Pharmaceutical Properties (2000) (0)
Haemopoietic growth factors and haematological malignancies. (1990) (0)
[Hemopoietic growth factors: their biological effects and the prospects for their clinical use]. (1991) (0)
Growth and Development of Haemopoietic Cells (1989) (0)
Stimulatory effects of recombinant human megakaryocyte growth and development factor in long-term bone marrow cultures of patients of acute myeloid leukaemia (1996) (0)
Interleukin-3-specific modification of cell membrane "fluidity" of haemopoietic cells. (1988) (0)
Colony-stimulating factors: future prospects. (1990) (0)
TOTAL BODY IRRADIATION AND AUTOLOGOUS BONE-MARROW INFUSION FOR RELAPSED ACUTE LEUKAEMIA (1986) (0)
Lymphoid antigens on non-lymphoid haematopoietic cell lines (1982) (0)
Proceedings: Colony studies in refractory cytopenia. (1976) (0)
Granulocyte Colony-Stimulating Factor (G-CSF) (1998) (0)
Relationship of lymphoid antigens, 20-α-SDH and “IL-3,” to lymphopoiesis☆☆☆ (1982) (0)
Gene transfer into hematopoietic cells by retroviral vectors (1988) (0)
The mobilisation of peripheral blood progenitor cells using chemotherapy, stem cell factor and filgrastim or chemotherapy plus filgrastim alone: a randomised study. (1997) (0)
Translocation of dna polymerase-α during the mitotic cycle of Physarum polycephalum (1992) (0)
Origin and development of mouse macrophages (1981) (0)
We wish to dedicate this volume to the memory of DR JOHN FREEMAN LOUTIT CBE, FRS who died on 11th June, 1992 at the age of 82 (1992) (0)
Long term ex vivo bone marrow culture (1987) (0)
Immunoelectron microscopic localization of growth factors and other markers in human long-term bone marrow cultures. (1996) (0)
20a steroid dehydrogenase expression in haematopoietic cultures and its relationship with Interlukin 3 (1982) (0)
Studies on the in vivo activity of a murine lymphokine, Interleukin (IL3), and the fate of IL3-depenent cell lines (1983) (0)
The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines. (1995) (0)
Expression of 20alpha-hydroxysteroid dehydrogenase in nonlympnoid hemopoietic cell lines. (1982) (0)
Relationship of haematopoietic growth factor to lymphocytes and Interleukin 3 (1984) (0)
Contents, Vol. 62, 1979 (1979) (0)
Cellular programmes for growth, differentiation and neoplasia Helsinki, Finland 19–23 July 1992 (1992) (0)
Ex-Vivo Treatment of Graft by Long-Term Culture (1993) (0)
Regulator-dependent haemopoiesis and its possible relevance to leukemogenesis. (1981) (0)
Combined use of lectin affinity chromatography and endo-beta-galactosidase to study polylactosamine sequences isolated from haemopoietic cell surfaces. (1986) (0)
Macrophage Inflammatory Protein 1a Attenuates the Toxic Effects of Temozolomide in Human Bone Marrow Granulocyte- Macrophage Colony-forming Cells (2000) (0)
Mechanisms involved in the response of hemopoietic cells to growth factors and stroma (1988) (0)
[Self-maintenance of hematopoietic precursor cells]. (1982) (0)
[Study on expression of adherent proteins related to regulation of hematopoiesis in long-term cultured human bone marrow stromal cells]. (1997) (0)
Marrow grown in long-term culture can be used for autologous transplantation in the treatment of acute myeloid leukaemia. (1989) (0)
Bcr-Abl tyrosine kinase activity induces a loss of p53 protein that mediates a delay in differentiation (2000) (0)
marrow cultures Molecular and cell biologic aspects of erythropoiesis in long-term bone (2011) (0)
Long-term in vitro correction of a-L-iduronidase deficiency ( Hurler syndrome ) in human bone marrow ( gene therapy / mucopolysaccharidosis type I / autosomal recessive ) (2005) (0)
Phase I Dose Toxicity Clinical Evaluation of Interleukin-4 (1994) (0)
Haemopoietic Cells as Targets for Gene Transfer (1989) (0)
Subject Index, Vol. 62, 1979 (1979) (0)
Long-term in vitro correction of a-L-iduronidase deficiency (Hurler syndrome) in human bone marrow (2005) (0)
INVESTIGATION OF THE MOLECULAR MECHANISMS BY WHICH SCF SYNERGISTICALLY PROMOTES THE EFFECTS OF CYTOKINES ON FDCP-MIX A4 CELLS (1995) (0)
Haemopoietic Growth Factors as Drugs (1990) (0)
[Will transfer of cytostatic drug resistance genes increase hematopoiesis resistance in the treatment of malignant tumors?]. (1997) (0)
Macrophage Inflammatory Protein 1 a Attenuates the Toxic Effects of Temozolomide in Human Bone Marrow Granulocyte-Macrophage Colony-forming Cells 1 (2000) (0)
Interferon-? Stimulates the Survival and Influences the Development of Bipotential Granulocyte-Macrophage Colony-Forming Cells By 0 (2003) (0)
Purification of aplastic anaemia (AA) marrow haemopoietic progenitors combined with long-term marrow cultures (LTMC) to assess haemopoiesis in AA. (1991) (0)
Growth factors in differentiation and development : a discussion (1990) (0)
Regulation of Haemopoietic Cell Development (1991) (0)
170. Differences in behaviour between AML and normal cells in long-term bone marrow culture used for a therapeutic approach (1992) (0)
Effects of interleukins on the proliferation and survival of chronic lymphocytic leukaemia cells. (1996) (0)

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