Michael Emerman
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Virology
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Molecular Biology
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Biology
Michael Emerman's Degrees
- PhD Molecular Biology University of California, San Francisco
- Bachelors Biology University of California, Santa Cruz
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(Suggest an Edit or Addition)Michael Emerman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing (2020) (3012)
- The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. (1994) (952)
- Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene (1992) (940)
- A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells (1993) (888)
- Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus (1994) (852)
- Visualization of the intracellular behavior of HIV in living cells (2002) (821)
- Genome organization and transactivation of the human immunodeficiency virus type 2 (1987) (818)
- Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain. (2005) (664)
- HIV-1 accessory proteins--ensuring viral survival in a hostile environment. (2008) (611)
- HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo (1998) (563)
- Human immunodeficiency virus infection of cells arrested in the cell cycle. (1992) (537)
- Ancient Adaptive Evolution of the Primate Antiviral DNA-Editing Enzyme APOBEC3G (2004) (474)
- The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection (1995) (456)
- A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing (2020) (456)
- HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology. (1998) (437)
- Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI. (1991) (410)
- Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism (1984) (406)
- The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization (1989) (402)
- Retroviral DNA Integration: Viral and Cellular Determinants of Target-Site Selection (2006) (376)
- HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. (1998) (371)
- Capsid Is a Dominant Determinant of Retrovirus Infectivity in Nondividing Cells (2004) (326)
- Evolutionary conflicts between viruses and restriction factors shape immunity (2012) (304)
- Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control (1996) (286)
- Single amino-acid changes in HIV envelope affect viral tropism and receptor binding (1989) (269)
- The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. (2012) (265)
- Nuclear import and cell cycle arrest functions of the HIV‐1 Vpr protein are encoded by two separate genes in HIV‐2/SIV(SM). (1996) (248)
- HIV-1 infection requires a functional integrase NLS. (2001) (239)
- Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins (2008) (219)
- Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses. (1997) (213)
- Human Immunodeficiency Virus Type 1 Tat Induces Apoptosis and Increases Sensitivity to Apoptotic Signals by Up-Regulating FLICE/Caspase-8 (1999) (208)
- HIV-1 Sequence Variation Drift, Shift, and Attenuation (2001) (208)
- Evidence for Direct Involvement of the Capsid Protein in HIV Infection of Nondividing Cells (2007) (197)
- Adaptive Evolution and Antiviral Activity of the Conserved Mammalian Cytidine Deaminase APOBEC3H (2006) (197)
- Antiretroelement activity of APOBEC3H was lost twice in recent human evolution. (2008) (196)
- Retroviral infection of non-dividing cells: old and new perspectives. (2006) (186)
- Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts. (1994) (184)
- HIV-1, Vpr and the cell cycle (1996) (184)
- Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals (2007) (181)
- Positive Selection and Increased Antiviral Activity Associated with the PARP-Containing Isoform of Human Zinc-Finger Antiviral Protein (2008) (169)
- Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. (1999) (166)
- Reassessment of the Roles of Integrase and the Central DNA Flap in Human Immunodeficiency Virus Type 1 Nuclear Import (2002) (165)
- Uracil DNA Glycosylase Is Dispensable for Human Immunodeficiency Virus Type 1 Replication and Does Not Contribute to the Antiviral Effects of the Cytidine Deaminase Apobec3G (2006) (152)
- The Cell Cycle Independence of HIV Infections Is Not Determined by Known Karyophilic Viral Elements (2005) (148)
- Paleovirology—Modern Consequences of Ancient Viruses (2010) (146)
- Quantitative analysis of gene suppression in integrated retrovirus vectors (1986) (145)
- Ancient Adaptive Evolution of Tetherin Shaped the Functions of Vpu and Nef in Human Immunodeficiency Virus and Primate Lentiviruses (2010) (143)
- Binding of Human Immunodeficiency Virus Type 1 to Immature Dendritic Cells Can Occur Independently of DC-SIGN and Mannose Binding C-Type Lectin Receptors via a Cholesterol-Dependent Pathway (2003) (140)
- Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA. (2012) (128)
- Restriction of an Extinct Retrovirus by the Human TRIM5α Antiviral Protein (2007) (128)
- The cytoplasmic domain of simian immunodeficiency virus transmembrane protein modulates infectivity (1989) (128)
- The specificity of the human immunodeficiency virus type 2 transactivator is different from that of human immunodeficiency virus type 1. (1987) (127)
- Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest (1997) (126)
- Cell Cycle- and Vpr-Mediated Regulation of Human Immunodeficiency Virus Type 1 Expression in Primary and Transformed T-Cell Lines (1999) (121)
- Conservation and host specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentivirus evolution and biology (1997) (116)
- High-Frequency Persistence of an Impaired Allele of the Retroviral Defense Gene TRIM5α in Humans (2006) (115)
- Evidence for a cytopathogenicity determinant in HIV-1 Vpr (2002) (112)
- VPX mutants of HIV‐2 are infectious in established cell lines but display a severe defect in peripheral blood lymphocytes. (1989) (111)
- Gene acquisition in HIV and SIV (1996) (109)
- Convergence and Divergence in the Evolution of the APOBEC3G-Vif Interaction Reveal Ancient Origins of Simian Immunodeficiency Viruses (2013) (109)
- Paleovirology - ghosts and gifts of viruses past. (2011) (108)
- Activation of a beta-galactosidase recombinant provirus: application to titration of human immunodeficiency virus (HIV) and HIV-infected cells (1990) (106)
- The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict. (2012) (102)
- An In Vitro Rapid-Turnover Assay for Human Immunodeficiency Virus Type 1 Replication Selects for Cell-to-Cell Spread of Virus (2000) (100)
- Comparison of promoter suppression in avian and murine retrovirus vectors. (1986) (89)
- Gene loss and adaptation to hominids underlie the ancient origin of HIV-1. (2013) (89)
- Natural Polymorphisms in Human APOBEC3H and HIV-1 Vif Combine in Primary T Lymphocytes to Affect Viral G-to-A Mutation Levels and Infectivity (2014) (86)
- High-frequency deletion in recovered retrovirus vectors containing exogenous DNA with promoters (1984) (85)
- HIV-1 infection of non-dividing cells (1994) (85)
- Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein. (2007) (85)
- Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1 (2013) (84)
- Cyclophilin A interacts with diverse lentiviral capsids (2006) (83)
- Human Trim5α has additional activities that are uncoupled from retroviral capsid recognition. (2011) (76)
- A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV (2018) (75)
- The Range of Human APOBEC3H Sensitivity to Lentiviral Vif Proteins (2009) (72)
- Dendritic Cell-Mediated Viral Transfer to T Cells Is Required for Human Immunodeficiency Virus Type 1 Persistence in the Face of Rapid Cell Turnover (2002) (72)
- Host gene evolution traces the evolutionary history of ancient primate lentiviruses (2013) (71)
- An expanded clade of rodent Trim5 genes. (2009) (67)
- An evolutionary perspective on the broad antiviral specificity of MxA. (2013) (66)
- The Breadth of Antiviral Activity of Apobec3DE in Chimpanzees Has Been Driven by Positive Selection (2011) (62)
- Spleen necrosis virus, an avian immunosuppressive retrovirus, shares a receptor with the type D simian retroviruses (1992) (62)
- Polymorphism in Human APOBEC3H Affects a Phenotype Dominant for Subcellular Localization and Antiviral Activity (2011) (61)
- Effects of mutations in hyperconserved regions of the extracellular glycoprotein of human immunodeficiency virus type 1 on receptor binding (1989) (58)
- Vpx association with mature core structures of HIV-2. (1996) (57)
- The DEAD-box RNA Helicase DDX6 is Required for Efficient Encapsidation of a Retroviral Genome (2011) (56)
- The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest. (2004) (55)
- Instability of large direct repeats in retrovirus vectors (1987) (47)
- Erratum: Human immunodeficiency virus infection of cells arrested in the cell cycle. The EMBO Journal (1992)11(3053-3058) (1992) (47)
- Incorporation of human immunodeficiency virus type 1 Gag proteins into murine leukemia virus virions (1993) (44)
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing (2020) (43)
- Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction (2015) (43)
- A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses (2016) (42)
- Cellular Restriction Targeting Viral Capsids Perturbs Human Immunodeficiency Virus Type 1 Infection of Nondividing Cells (2009) (41)
- Protein stability influences human immunodeficiency virus type 2 Vpr virion incorporation and cell cycle effect. (1996) (41)
- Small heat shock protein suppression of Vpr-induced cytoskeletal defects in budding yeast (1997) (38)
- Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations. (2013) (37)
- Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes (2013) (37)
- The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys (2015) (36)
- An Evolutionary Screen Highlights Canonical and Noncanonical Candidate Antiviral Genes within the Primate TRIM Gene Family (2013) (36)
- Functional exchange of an oncoretrovirus and a lentivirus matrix protein (1994) (36)
- Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization (2017) (35)
- Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment (2016) (35)
- Determinants of cyclophilin A-dependent TRIM5 alpha restriction against HIV-1. (2008) (35)
- Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells (2017) (31)
- Molecular basis of cell cycle dependent HIV-1 replication. Implications for control of virus burden. (1995) (31)
- Identification of Postentry Restrictions to Mason-Pfizer Monkey Virus Infection in New World Monkey Cells (2008) (31)
- Simian Immunodeficiency Virus SIVagm from African Green Monkeys Does Not Antagonize Endogenous Levels of African Green Monkey Tetherin/BST-2 (2009) (30)
- The function and evolution of the restriction factor viperin in primates was not driven by lentiviruses (2012) (28)
- Antagonism of SAMHD1 is actively maintained in natural infections of simian immunodeficiency virus (2013) (28)
- Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates (2020) (27)
- TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner (2020) (26)
- Primary Isolates of Human Immunodeficiency Virus Type 1 Are Usually Dominated by the Major Variants Found in Blood (2007) (26)
- Cleavage and cross-linking of proteins with osmium (VII) reagents. (1982) (24)
- Genetic Drift of HIV Populations in Culture (2009) (23)
- Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution. (2016) (21)
- Learning from lentiviruses (2000) (19)
- A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses (2014) (17)
- Simian Immunodeficiency Virus Variants That Differ in Pathogenicity Differ in Fitness under Rapid Cell Turnover Conditions (2005) (17)
- A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery (2018) (16)
- HIV-1 INFECTION OF NON-DIVIDING CELLS. AUTHORS' REPLY (1994) (15)
- How TRIM5α defends against retroviral invasions (2006) (14)
- HIV: Going for the watchman (2011) (14)
- Evolutionary Landscapes of Host-Virus Arms Races. (2022) (13)
- HIV-1 Vpr does not inhibit CTL-mediated apoptosis of HIV-1 infected cells. (2002) (12)
- Polymorphisms in Human APOBEC3H Differentially Regulate Ubiquitination and Antiviral Activity (2020) (12)
- From curse to cure: HIV for gene therapy? (1996) (11)
- Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races (2020) (11)
- Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism. (2019) (10)
- Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner (2019) (10)
- The Mongoose, the Pheasant, the Pox, and the Retrovirus (2013) (10)
- A competition model for viral inhibition of host cell proliferation. (2000) (8)
- Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins (2019) (8)
- Advances in HIV molecular biology. (2002) (8)
- Trim5 TAKes on pattern recognition. (2011) (8)
- Proceedings of the Frontiers of Retrovirology Conference 2016 (2016) (7)
- Controlling lentiviruses: single amino acid changes can determine specificity. (2004) (6)
- How TRIM5alpha defends against retroviral invasions. (2006) (6)
- Recurrent Loss of APOBEC3H Activity during Primate Evolution (2018) (6)
- Direct detection of infectious HIV-1 in blood using a centrifugation-indicator cell assay. (2000) (5)
- Insertion of genes into retrovirus genomes and of retrovirus DNA into cell genomes. (1985) (5)
- A Plea for Justice for Jailed Medical Workers (2006) (5)
- Combinatorial mutagenesis of rapidly-evolving residues yields super-restrictor antiviral proteins (2019) (4)
- [12] Quantitation of virus stocks produced from cloned human immunodeficiency virus DNA (1995) (4)
- Determinants of Cyclophilin A-dependent TRIM5 α restriction against HIV-1 (2009) (4)
- Functional mapping of the rev-responsive element of human immunodeficiency virus type 2 (HIV-2): influence of HIV-2 envelope-encoding sequences on HIV-1 gp120 expression in the presence or absence of Rev. (1992) (4)
- Virology under the Microscope—a Call for Rational Discourse (2023) (4)
- Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms (2021) (4)
- A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency (2022) (3)
- VPX mutantsofHIV-2areinfectious inestablished cell lines butdisplay a severedefect inperipheral blood lymphocytes (1989) (2)
- RNA tumor virus update. (1991) (2)
- APOBEC3C Tandem Domain Proteins Create Super Restriction Factors against HIV-1 (2020) (2)
- from DNA damage checkpoint control. G2 accumulation by a mechanism which differs cycle control: Vpr is cytostatic and mediates Human immunodeficiency virus type 1 cell (2014) (1)
- The function and evolution of the restriction factor viperin in primates was not driven by lentiviruses (2012) (1)
- Virology under the Microscope—a Call for Rational Discourse (2023) (1)
- TRIM34 acts with TRIM5 to restrict HIV and SIV capsids (2019) (1)
- Divergence in Dimerization and Activity of Primate APOBEC3C (2021) (1)
- Decision letter: KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides (2019) (1)
- Evolution-guided design of super-restrictor antiviral proteins reveals a breadth-versus-specificity tradeoff (2019) (1)
- Virology under the Microscope—a Call for Rational Discourse (2023) (1)
- T-Cell Derived Suppressor Factors in the Regulation of Humoral Immunity (1988) (1)
- HIV-1 Vif Gained Breadth in APOBEC3G Specificity after Cross-Species Transmission of Its Precursors (2021) (1)
- 43 Utilization of a Burn Sepsis Algorithm: Should we Abandon the Consensus Criteria? (2018) (1)
- Incorporation ofHumanImmunodeficiency VirusType1 Gag Proteins intoMurineLeukemiaVirusVirions (1993) (0)
- Proceedings of the Frontiers of Retrovirology Conference 2016 (2016) (0)
- Cell Host & Microbe Previews Trim 5 TAKes on Pattern Recognition (2011) (0)
- Simian Immunodeficiency Virus SIV agm from African Green Monkeys Does Not Antagonize Endogenous Levels of African Green Monkey Tetherin/BST-2 (cid:1) (2009) (0)
- HIV and the cell cycle (1998) (0)
- Author‐initiated repurposing of reviews: the Streamline Reviews initiative at Virology (2014) (0)
- Identification of Postentry Restrictions to Mason-Pfizer Monkey Virus Infection in New World Monkey Cells (cid:1) (2008) (0)
- Instability ofLargeDirect Repeats inRetrovirus Vectors (1987) (0)
- Crystal structure of SIVrcm Vif-CBFbeta-ELOB-ELOC complex (2019) (0)
- Arnold Library: MCB532 Human Pathogenic Viruses: Class Schedule (2008) (0)
- A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery (2018) (0)
- Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor (2023) (0)
- Decision letter: HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137 (2020) (0)
- A Virus-Packageable CRISPR System Identifies Host Dependency Factors Across Multiple HIV-1 Strains (2022) (0)
- The Little Book of Viruses (2011) (0)
- The structural basis for HIV-1 Vif antagonism of human APOBEC3G (2023) (0)
- A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains (2023) (0)
- Nuclear import andcell cycle arrestfunctions ofthe HIV-1 Vprprotein areencodedbytwo separate genes inHIV-2/SIVsM (1996) (0)
- Comparison ofpromoter suppression inavian andmurineretrovirus vectors (1986) (0)
- GUEST COMMENTARY Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins (2009) (0)
- LibGuides: MCB 532 Human Pathogenic Viruses: Lectures and Discussion Papers (2008) (0)
- A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection (2022) (0)
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What Schools Are Affiliated With Michael Emerman?
Michael Emerman is affiliated with the following schools:
